CN109602776A - A kind of hydrogen manufacturing Chinese medicine package and preparation method thereof - Google Patents
A kind of hydrogen manufacturing Chinese medicine package and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B3/00—Hydrogen; Gaseous mixtures containing hydrogen; Separation of hydrogen from mixtures containing it; Purification of hydrogen
- C01B3/02—Production of hydrogen or of gaseous mixtures containing a substantial proportion of hydrogen
- C01B3/06—Production of hydrogen or of gaseous mixtures containing a substantial proportion of hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents
- C01B3/08—Production of hydrogen or of gaseous mixtures containing a substantial proportion of hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents with metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/36—Hydrogen production from non-carbon containing sources, e.g. by water electrolysis
Abstract
The present invention relates to traditional Chinese medicine health care product fields, disclose a kind of hydrogen manufacturing Chinese medicine package and preparation method thereof, hydrogen manufacturing Chinese medicine package includes packaging bag and the functional powder that is encapsulated in packaging bag, packaging bag is made of air-and water-permeable material, functional powder contains medicinal ingredient and can react that generate hydrogen and exothermic hydrogen manufacturing ingredient, hydrogen manufacturing ingredient include aluminium powder and sodium carbonate with water.Hydrogen manufacturing Chinese medicine package the preparation method comprises the following steps: by functional powder packaging by hot pressing in packaging bag.Functional powder containing hydrogen manufacturing ingredient and medicinal ingredient is encapsulated in formation hydrogen manufacturing Chinese medicine package in the packaging bag of water-permeable and air permeable by the present invention, it is directly placed into water when shower, hydrogen manufacturing ingredient in functional powder, which can react to generate hydrogen and release heat with water, heats water, medicinal ingredient in promotion functions powder releases effective component, it is easy to operate without shifting to an earlier date decocting herb material.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product fields, more particularly, to a kind of hydrogen manufacturing Chinese medicine package and preparation method thereof.
Background technique
Dipping is a kind of unique administration route, is first to add water to cook Chinese medicine, then taking liquid bathing part or complete
Body.Dipping has good effect to the conditioning of inferior health and the health care of human body, and the medicine ion in dip passes through skin and mucosa
The approach such as absorption, diffusion, radiation enter in vivo, avoid liver first-pass effect, reduce toxic side effect.While dip
Thermogenetic effect can be improved the temperature of tissue, and diastole capillary improves circulation, accelerates blood, and is inhaled by skin histology
After receipts, local immunological status is adjusted, inhibits and reduce the release of bioactive substance, to achieve the purpose that disease preventing and treating.
But taking liquid is taken a shower again after in advance adding water to cook Chinese medicine, and temperature is difficult to control；When complex procedures, consuming
Between；And the bad taking-up of the dregs of a decoction, the dregs of a decoction are easy to be stained with the comfort level for influencing to take a shower on the skin when shower.
The body of people will operate, and energy must be just generated by aoxidizing, at this moment will be generated free radicals, a small amount of free radical
Be to human body it is beneficial, it can decompose intracorporal non-viable non-apoptotic cell, eliminate alien bacteria, but excessive free radical is to body
Harm is destructive.The aging of people is to cause the master of cytopathic or aging due to caused by cell senescence or necrosis
Wanting arch-criminal is exactly superfluous oxygen radical.Scientist will eliminate oxygen it has proven convenient that oxygen radical is at least related with more than 100 kinds of diseases
Free radical is translated into the water beneficial to body it is necessary to give its electronics.Hydrogen is that one kind is colourless, tasteless, nontoxic and odorless
Gas, and hydrogen has powerful penetrability, can very easily enter intracellular, and hydrogen has anti-oxidant, anti-inflammatory
Characteristic can effectively restore and remove active oxygen radical, and improve to oxygen radical and energetic supersession level, therefore for
Esoteric all kinds of lesions have well improve control action, such as improve immunity, anti-aging, antifatigue, cardiovascular and cerebrovascular,
Discovery has good improvement result for cancer patient even in clinical test for diabetes, uric acid height etc..
Hydrogen-rich water rich in hydrogen is widely paid close attention in the international market, if by hydrogen-rich water effective for medicine
In bath, so that it may improve human health under the collective effect of Chinese medicine and hydrogen, yet there are no research in this respect.
Summary of the invention
The present invention be in order to overcome in existing dipping, Chinese medicine need to first add water to cook after again taking liquid take a shower, temperature
Degree is difficult to control；Complex procedures expend the time；And the bad taking-up of the dregs of a decoction, influence take a shower comfort level the problem of, a kind of system is provided
Hydrogen Chinese medicine package and preparation method thereof, without being decocted in advance to Chinese medicine when carrying out dipping using the Chinese medicine package, and dipping
Hydrogen be can produce in journey for removing the intracorporal oxygen radical of people, preferably improved under the collective effect of Chinese medicine and hydrogen
Human health.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of hydrogen manufacturing Chinese medicine package, including packaging bag and the functional powder being encapsulated in packaging bag, the packaging bag is by ventilative saturating
Water material is made, the functional powder contain medicinal ingredient and being reacted with water generate hydrogen and exothermic hydrogen manufacturing at
Point, the hydrogen manufacturing ingredient includes aluminium powder and sodium carbonate.
Functional powder containing hydrogen manufacturing ingredient and medicinal ingredient is encapsulated in the packaging bag of water-permeable and air permeable and forms hydrogen manufacturing
Chinese medicine package, when shower directly by hydrogen manufacturing Chinese medicine package into the water, the hydrogen manufacturing ingredient in functional powder can react generation with water
Hydrogen is simultaneously released heat and is heated to water, the medicinal ingredient in promotion functions powder release in a heated condition effectively at
Point.The hydrogen of generation can restore excessive oxygen radical in human body, for human body improve immunity, anti-aging, it is antifatigue and
Control cardiovascular and cerebrovascular disease, diabetes, uric acid height etc. have improvement result.Medicinal ingredient releases effective in a heated condition
Ingredient enters in water, by the approach such as the absorption, diffusion, radiation of skin and mucosa enter in vivo, human body can be played health care and
The effect of disease preventing and treating.Hydrogen manufacturing ingredient, which reacts the heat released with water, effectively water to be made to keep the temperature.It is carried out using hydrogen manufacturing Chinese medicine package
When dipping, can use hydrogen production reaction releasing heat medicinal material is heated, without being decocted to medicinal material, it is easy to operate just
It is prompt and the dregs of a decoction will not be generated, moreover it is possible to the lasting water temperature for keeping taking a shower.
Aluminium can react under alkaline condition with water generates hydrogen, reaction equation are as follows:
2Al+6H2O=2Al(OH)3+3H2↑
Become using aluminium powder and sodium carbonate as hydrogen manufacturing, sodium carbonate can provide alkaline ring after being dissolved in water for the reaction of aluminium powder and water
Border, and aqueous sodium carbonate is harmless, will not generate corrosion to skin as strong base solution.When aluminum particle is smaller, compare table
When area is larger, aluminium powder reacts acutely with water, can release amount of heat and heat to water, to promote to have in medicinal ingredient
Imitate the release of ingredient.Meanwhile mixing aluminium powder with sodium carbonate and medicinal ingredient, sodium carbonate and medicinal ingredient can also be in reaction process
The middle contact area for reducing aluminium powder and water, adjusts the reaction rate of aluminium powder and water, avoids aluminium powder from reacting with water and too acutely leads
It causes local temperature excessively high, influences the comfort level taken a shower.
Preferably, hydrogen manufacturing ingredient accounts for the 20-90% of functional powder gross mass, medicinal ingredient accounts for the total matter of functional powder
The 10-80% of amount.
Preferably, aluminium powder accounts for the 33-97.6% of hydrogen manufacturing ingredient gross mass, sodium carbonate accounts for the 2.4- of hydrogen manufacturing ingredient gross mass
67%。
Preferably, the partial size of aluminium powder is 0.2 μm of -2mm, the partial size of sodium carbonate is 0.5 μm of -1mm.Partial size is too small, reaction
Can be too violent, cause hot-spot；The excessive reaction of partial size again can too slowly, and the shortage of heat of generation is so that medicinal material mixed powder
Effective component in end releases.
Preferably, medicinal ingredient includes folium artemisiae argyi, honeysuckle, chrysanthemum, wrinkled giant hyssop, peppermint, Radix Glycyrrhizae, santal, rose, mulberry leaf
At least one of.
Preferably, the material of packaging bag is non-woven fabrics, nonwoven cloth material effectively can absorb water and breathe freely.
The present invention also provides a kind of preparation methods of above-mentioned hydrogen manufacturing Chinese medicine package: functional powder packaging by hot pressing is being packed
In bag.
Preferably, functional powder the preparation method comprises the following steps: weigh aluminium powder, sodium carbonate and medicinal ingredient respectively, mixing is simultaneously
It crushes up to functional powder.
Preferably, the preparation method of functional powder the following steps are included:
(1) dry folium artemisiae argyi is ground into powder to be added the deionized water for being 10:1-15:1 with Argy Wormwood Leaf mass ratio, impregnates 2-
3h；
(2) oil bath heating collects oil reservoir liquid after keeping slightly boiled 4-5h to boiling；
(3) ether is added in the oil reservoir liquid being collected into, after standing 1-2h, supernatant liquid is taken to rotate under 40-50 DEG C of water-bath
Volatile argyi leaf oil is obtained after evaporation 1-2h；
(4) 1:(1-2 in mass ratio): (5-10): (50-100) is by volatile argyi leaf oil, soybean lecithin, cholesterol and sodium taurocholate
Chloroform dissolution is added in mixing；
(5) rotary evaporation 1-2h under 30-50 DEG C of water-bath is revolved after being dried in vacuo 10-12h at room temperature after film forming with phosphate buffer
Turn to wash film；
(6) folium artemisiae argyi is obtained with filtering with microporous membrane and is waved with after ultrasonic cell disruptor ultrasound 5-10min under the conditions of ice-water bath
Hair oil liposome；
(7) it is added in aluminium powder water-soluble with the cetyl trimethylammonium bromide for the 1-2mol/L that aluminium powder mass ratio is 5:1-10:1
Liquid after ultrasonic disperse 20-30min, stirs 1-2h at room temperature, be filtered, washed, dry after obtain positively charged aluminium powder；
(8) positively charged aluminium powder is added to the water ultrasonic disperse 20-30min and forms aluminium powder dispersion liquid, by volatile argyi leaf oil rouge
Plastid is added to the water to obtain volatile argyi leaf oil liposome suspension, and volatile argyi leaf oil is added in aluminium powder dispersion liquid under agitation
In liposome suspension, vacuum drying 12-24h is obtained using volatile argyi leaf oil liposome as core, aluminium at 40-50 DEG C after standing 1-2h
Powder is the core-shell structure compound particle of shell,
(9) core-shell structure compound particle is mixed with sodium carbonate and is crushed up to functional powder.
Volatile argyi leaf oil is the principle active component in folium artemisiae argyi, have antibacterial, it is antiviral, relieving asthma, antibechic, eliminating the phlegm, anti-mistake
Quick, immune, protect liver cholagogue promotes the effects of digestion, complement activation.Only by being heated to Argy Wormwood Leaf, released in Argy Wormwood Leaf
Volatile argyi leaf oil it is limited, therefore limited efficacy if volatile argyi leaf oil extracted from Argy Wormwood Leaf, is directly used in
Hydrogen manufacturing Chinese medicine package can greatly improve the drug effect of hydrogen manufacturing Chinese medicine package.
But volatile argyi leaf oil is oily liquids and volatile, be cannot be used directly in hydrogen manufacturing Chinese medicine package, therefore the present invention is first
Volatile argyi leaf oil is encapsulated in lipid bilayer, has been made solid volatile argyi leaf oil liposome, then aluminium powder is passed through quiet
Electric self assembly effect is coated on outside volatile argyi leaf oil liposome, forms core-shell structure compound particle.Under the protection of outer layer aluminium powder,
Lipid bilayer in volatile argyi leaf oil liposome is not easy to be destroyed in daily storage, is encapsulated in lipid bilayer
Volatile argyi leaf oil will not volatilize, and compound particle can be stored effectively.When hydrogen manufacturing Chinese medicine package into the water, outer layer aluminium powder exists
It is reacted in the alkaline environment that sodium carbonate provides with water and generates hydrogen and release heat, lipid bilayer occurs under alkaline condition
Hydrolysis makes to be encapsulated in internal volatile argyi leaf oil and releases into being absorbed by the body in water, heating can also promote to destroying
The destruction of lipid bilayer.
Volatile argyi leaf oil is extracted from folium artemisiae argyi using steam distillation in step (1)-(3)；Step (4)-(6) use film
The negatively charged volatile argyi leaf oil liposome in surface is made in dispersion method；Step (7) is modified aluminium powder surface, so that aluminium powder table
Face has positive charge；Step (8) is acted on by electrostatic self-assembled, makes the volatile argyi leaf oil liposome and surface that surface is negatively charged
Electrostatic self-assembled occurs for the aluminium powder with positive charge, and being formed by core, aluminium powder of volatile argyi leaf oil liposome is the core-shell structure of shell
Compound particle.
Preferably, crushing revolving speed is that 300-500 turns/min, the temperature of grinding time 5-10min, packaging by hot pressing are
250-300℃。
Therefore, the invention has the following beneficial effects:
(1) functional powder containing hydrogen manufacturing ingredient and medicinal ingredient is encapsulated in the packaging bag of water-permeable and air permeable and is formed in hydrogen manufacturing
Pack, when shower directly by hydrogen manufacturing Chinese medicine package into the water, the hydrogen manufacturing ingredient in functional powder can be reacted with water generates hydrogen
Gas is simultaneously released heat and is heated to water, the medicinal ingredient in promotion functions powder release in a heated condition effectively at
Point, it is easy to operate without decocting herb material in advance, and the hydrogen generated can restore excessive oxygen radical in human body, for
Human body, which improves immunity, anti-aging, antifatigue and control cardiovascular and cerebrovascular disease, diabetes, uric acid height etc., improvement result；
(2) using aluminium powder and sodium carbonate as hydrogen manufacturing ingredient, aluminium powder can react under alkaline environment with water to be generated hydrogen and puts
Heat out, aqueous sodium carbonate can provide alkaline environment and sodium carbonate is harmless, will not generate corrosion, carbonic acid to skin
Sodium and medicinal ingredient can also reduce the contact area of aluminium powder and water during the reaction, adjust the reaction rate of aluminium powder and water, keep away
Exempt from aluminium powder to react too violent with water and cause local temperature excessively high, influences the comfort level taken a shower；
(3) use using volatile argyi leaf oil liposome as core, aluminium powder for shell core-shell structure compound particle and sodium carbonate as function
Property powder, the good drug efficacy of volatile argyi leaf oil, when daily storage, volatile argyi leaf oil will not discharge and volatilize, into the water after in alkali
It can be released effectively under property environment and heating condition.
Detailed description of the invention
Fig. 1 is that hydrogen manufacturing Chinese medicine package obtained is put into hydrogen output and time history in 40 DEG C of water in embodiment 1-6；
Fig. 2 is that hydrogen manufacturing Chinese medicine package obtained is put into hydrogen output and time history in 40 DEG C of water in embodiment 7-9；
Fig. 3 is that hydrogen manufacturing Chinese medicine package obtained is put into hydrogen output and time history in different temperatures water in embodiment 2；
Fig. 4 is that hydrogen manufacturing Chinese medicine package obtained exposes the hydrogen output being put into after different time in 40 DEG C of water in air in embodiment 9
With time history.
Specific embodiment
The present invention will be further described with specific embodiment with reference to the accompanying drawing.
Embodiment 1:
It is calculated in mass percent, weighs the aluminium powder that 50% partial size is 200 μm, the powdered sodium carbonate that 10% partial size is 200 μm, 40%
Diameter is that 500 μm of Folium Artemisiae Argyi powder is put into pulverizer, obtains uniformly mixed functionality with the speed mixing 10min of 500 turns/min
Powder, by above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C
Packet.
Embodiment 2:
It is calculated in mass percent, weighs the aluminium powder that 65% partial size is 200 μm, the powdered sodium carbonate that 15% partial size is 200 μm, 20%
Diameter is that 500 μm of Folium Artemisiae Argyi powder is put into pulverizer, obtains uniformly mixed functionality with the speed mixing 10min of 500 turns/min
Powder, by above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C
Packet.
Embodiment 3:
It is calculated in mass percent, weighs the aluminium powder that 65% partial size is 200 μm, the powdered sodium carbonate that 15% partial size is 200 μm, 20%
Diameter is that 300 μm of Herba Menthae powder is put into pulverizer, obtains uniformly mixed functionality with the speed mixing 10min of 500 turns/min
Powder, by above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C
Packet.
Embodiment 4:
It is calculated in mass percent, weighs the aluminium powder that 10% partial size is 0.2 μm, the powdered sodium carbonate that 10% partial size is 0.5 μm, 80%
Diameter is that 500 μm of Folium Artemisiae Argyi powder is put into pulverizer, obtains uniformly mixed functionality with the speed mixing 10min of 500 turns/min
Powder, by above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C
Packet.
Embodiment 5:
It is calculated in mass percent, weighing powdered sodium carbonate, 10% partial size that aluminium powder, 10% partial size that 80% partial size is 2mm are 1mm is
500 μm of Folium Artemisiae Argyi powder is put into pulverizer, obtains uniformly mixed functional powder with the speed mixing 10min of 500 turns/min,
By above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine package in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C.
Embodiment 6:
It is calculated in mass percent, weighs the aluminium powder that 70% partial size is 200 μm, the powdered sodium carbonate that 20% partial size is 200 μm, 10%
Diameter is that 500 μm of Folium Artemisiae Argyi powder is put into pulverizer, obtains uniformly mixed functionality with the speed mixing 10min of 500 turns/min
Powder, by above-mentioned functional powder, packaging by hot pressing obtains hydrogen manufacturing Chinese medicine in the non-woven fabrics that densification is breathed freely in water suction at 260 DEG C
Packet.
Embodiment 7:
The preparation of core-shell structure compound particle: it is put into round-bottomed flask after the dry folium artemisiae argyi of 50g is ground into powder, 500g is added
Deionized water, impregnates 2h, and round-bottomed flask connect with volatile oil extractor after shaking up, is added in volatile oil extractor by mixing
10g deionized water and 1mL n-hexane；Round-bottomed flask is placed in and is slowly heated to boiling in oil bath pan, is collected after keeping slightly boiled 4h
Oil reservoir liquid；It is placed in separatory funnel after the oil reservoir liquid being collected into is mixed, appropriate ether is added, after standing 1h, takes upper liquid
Body obtains volatile argyi leaf oil after rotary evaporation 1h under 40 DEG C of water-baths, places after repeatedly extracting spare.
140g volatile argyi leaf oil and 200g soybean lecithin, 15g cholesterol and 1.5g sodium taurocholate are mixed, it is molten that chloroform is added
Solution；Rotary evaporation 1h under 30 DEG C of water-baths is dried in vacuo after film forming after 10h at room temperature and washes film with phosphate buffer rotation；In ice
With after ultrasonic cell disruptor ultrasound 5min under water bath condition, volatile argyi leaf oil liposome is obtained with filtering with microporous membrane.
The cetyl trimethylammonium bromide aqueous solution of 500g 2mol/L, ultrasonic disperse 20min are added in 100g aluminium powder
Afterwards, magnetic agitation 2h at room temperature, be filtered, washed, dry after obtain positively charged aluminium powder；Water is added in positively charged aluminium powder
Middle ultrasonic disperse 20min forms aluminium powder dispersion liquid, and volatile argyi leaf oil liposome is added to the water to obtain volatile argyi leaf oil liposome
Aluminium powder dispersion liquid is added in volatile argyi leaf oil liposome suspension suspension under agitation, true at 40 DEG C after standing 1h
The dry 12h of sky obtains core-shell structure compound particle.
It is calculated in mass percent, weighs 90% core-shell structure compound particle and 10% powdered sodium carbonate is put into pulverizer, with
The speed mixing 5min of 300 turns/min obtains uniformly mixed functional powder, by the hot pressing at 250 DEG C of above-mentioned functional powder
It is encapsulated in the ventilative fine and close non-woven fabrics of water suction and obtains hydrogen manufacturing Chinese medicine package.
Embodiment 8:
The preparation of core-shell structure compound particle: it is put into round-bottomed flask after the dry folium artemisiae argyi of 50g is ground into powder, 750g is added
Deionized water, impregnates 3h, and round-bottomed flask connect with volatile oil extractor after shaking up, is added in volatile oil extractor by mixing
10g deionized water and 1mL n-hexane；Round-bottomed flask is placed in and is slowly heated to boiling in oil bath pan, is collected after keeping slightly boiled 5h
Oil reservoir liquid；It is placed in separatory funnel after the oil reservoir liquid being collected into is mixed, appropriate ether is added, after standing 2h, takes upper liquid
Body obtains volatile argyi leaf oil after rotary evaporation 2h under 50 DEG C of water-baths, places after repeatedly extracting spare.
100g volatile argyi leaf oil and 200g soybean lecithin, 10g cholesterol and 1g sodium taurocholate are mixed, it is molten that chloroform is added
Solution；Rotary evaporation 2h under 50 DEG C of water-baths is dried in vacuo after film forming after 12h at room temperature and washes film with phosphate buffer rotation；In ice
With after ultrasonic cell disruptor ultrasound 10min under water bath condition, volatile argyi leaf oil liposome is obtained with filtering with microporous membrane.
The cetyl trimethylammonium bromide aqueous solution of 1000g 1mol/L, ultrasonic disperse are added in 100g aluminium powder
After 30min, magnetic agitation 1h at room temperature, be filtered, washed, dry after obtain positively charged aluminium powder；By positively charged aluminium powder
It is added to the water ultrasonic disperse 30min and forms aluminium powder dispersion liquid, is added to the water volatile argyi leaf oil liposome to obtain volatile argyi leaf oil
Aluminium powder dispersion liquid is added in volatile argyi leaf oil liposome suspension liposome suspension under agitation, stands 50 after 2h
It is dried in vacuo at DEG C and obtains core-shell structure compound particle for 24 hours.
It is calculated in mass percent, weighs 80% core-shell structure compound particle and 20% powdered sodium carbonate is put into pulverizer, with
The speed mixing 8min of 400 turns/min obtains uniformly mixed functional powder, by the hot pressing at 300 DEG C of above-mentioned functional powder
It is encapsulated in the ventilative fine and close non-woven fabrics of water suction and obtains hydrogen manufacturing Chinese medicine package.
Embodiment 9:
The preparation of core-shell structure compound particle: it is put into round-bottomed flask after the dry folium artemisiae argyi of 50g is ground into powder, 600g is added
Deionized water, impregnates 2.5h, and round-bottomed flask connect with volatile oil extractor after shaking up, is added in volatile oil extractor by mixing
10g deionized water and 1mL n-hexane；Round-bottomed flask is placed in and is slowly heated to boiling in oil bath pan, is received after keeping slightly boiled 4.5h
Collect oil reservoir liquid；It is placed in separatory funnel after the oil reservoir liquid being collected into is mixed, appropriate ether is added, after standing 1.5h, is taken
Layer liquid obtains volatile argyi leaf oil after rotary evaporation 1.5h under 45 DEG C of water-baths, places after repeatedly extracting spare.
100g volatile argyi leaf oil and 200g soybean lecithin, 20g cholesterol and 2g sodium taurocholate are mixed, it is molten that chloroform is added
Solution；Rotary evaporation 1.5h under 40 DEG C of water-baths is dried in vacuo after film forming after 11h at room temperature and washes film with phosphate buffer rotation；?
With after ultrasonic cell disruptor ultrasound 8min under the conditions of ice-water bath, volatile argyi leaf oil liposome is obtained with filtering with microporous membrane.
The cetyl trimethylammonium bromide aqueous solution of 600g 1.5mol/L, ultrasonic disperse are added in 100g aluminium powder
After 25min, magnetic agitation 1.5h at room temperature, be filtered, washed, dry after obtain positively charged aluminium powder；By positively charged aluminium
Powder is added to the water ultrasonic disperse 25min and forms aluminium powder dispersion liquid, and volatile argyi leaf oil liposome is added to the water to obtain folium artemisiae argyi volatilization
Aluminium powder dispersion liquid is added in volatile argyi leaf oil liposome suspension oil lipidosome suspension under agitation, stands 1.5h
Vacuum drying 20h obtains core-shell structure compound particle at 45 DEG C afterwards.
It is calculated in mass percent, weighs 85% core-shell structure compound particle and 15% powdered sodium carbonate is put into pulverizer, with
The speed mixing 10min of 500 turns/min obtains uniformly mixed functional powder, and above-mentioned functional powder is warm at 260 DEG C
Press seal obtains hydrogen manufacturing Chinese medicine package in the ventilative fine and close non-woven fabrics of water suction.
Hydrogen manufacturing Chinese medicine package obtained in above-described embodiment is put into 40 DEG C of water respectively, measures hydrogen output, as a result such as Fig. 1 and
Shown in Fig. 2.It can be seen that by data in figure, hydrogen manufacturing Chinese medicine package is put into 40 DEG C of water, and hydrogen manufacturing Chinese medicine package can generate rapidly hydrogen,
Hydrogen output can achieve 700-1250mg/L.
By hydrogen manufacturing Chinese medicine package obtained in embodiment 2 be respectively put into 30 DEG C, 40 DEG C, in 70 DEG C of water, measure hydrogen output, as a result
As shown in figure 3, it can be seen that hydrogen manufacturing Chinese medicine package hydrogen output in the higher water of temperature is also bigger.
Hydrogen manufacturing Chinese medicine package obtained in embodiment 9 is exposed into 0 day, 15 days, 30 days, 45 days, 60 days in air respectively, then
By exposure different number of days hydrogen manufacturing Chinese medicine package be put into 40 DEG C of water, measure hydrogen output, as a result as shown in figure 4, it can be seen that
In air after 60-day Exposure, hydrogen manufacturing Chinese medicine package still can effectively produce hydrogen.
Claims (10)
1. a kind of hydrogen manufacturing Chinese medicine package, characterized in that including packaging bag and the functional powder being encapsulated in packaging bag, the packaging
Bag is made of air-and water-permeable material, and the functional powder, which contains medicinal ingredient and can react with water, to be generated hydrogen and release heat
Hydrogen manufacturing ingredient, the hydrogen manufacturing ingredient includes aluminium powder and sodium carbonate.
2. a kind of hydrogen manufacturing Chinese medicine package according to claim 1, characterized in that the hydrogen manufacturing ingredient accounts for the total matter of functional powder
The 20-90% of amount, the medicinal ingredient account for the 10-80% of functional powder gross mass.
3. a kind of hydrogen manufacturing Chinese medicine package according to claim 2, characterized in that the aluminium powder accounts for hydrogen manufacturing ingredient gross mass
33-97.6%, the sodium carbonate account for the 2.4-67% of hydrogen manufacturing ingredient gross mass.
4. a kind of hydrogen manufacturing Chinese medicine package according to claim 1 or 3, characterized in that the partial size of the aluminium powder be 0.2 μm-
2mm, the partial size of the sodium carbonate are 0.5 μm of -1mm.
5. a kind of hydrogen manufacturing Chinese medicine package according to claim 3, characterized in that the medicinal ingredient include folium artemisiae argyi, honeysuckle,
At least one of chrysanthemum, wrinkled giant hyssop, peppermint, Radix Glycyrrhizae, santal, rose, mulberry leaf.
6. a kind of hydrogen manufacturing Chinese medicine package according to claim 1, characterized in that the material of the packaging bag is non-woven fabrics.
7. a kind of preparation method of hydrogen manufacturing Chinese medicine package according to claim 1, characterized in that seal functional powder hot pressing
In packaging bag.
8. a kind of preparation method of hydrogen manufacturing Chinese medicine package according to claim 7, characterized in that the system of the functional powder
Preparation Method are as follows: weigh aluminium powder, sodium carbonate and medicinal ingredient respectively, mix and crush up to functional powder.
9. a kind of preparation method of hydrogen manufacturing Chinese medicine package according to claim 7, characterized in that the system of the functional powder
Preparation Method the following steps are included:
(1) dry folium artemisiae argyi is ground into powder to be added the deionized water for being 10:1-15:1 with Argy Wormwood Leaf mass ratio, impregnates 2-
3h；
(2) oil bath heating collects oil reservoir liquid after keeping slightly boiled 4-5h to boiling；
(3) ether is added in the oil reservoir liquid being collected into, after standing 1-2h, supernatant liquid is taken to rotate under 40-50 DEG C of water-bath
Volatile argyi leaf oil is obtained after evaporation 1-2h；
(4) 1:(1-2 in mass ratio): (5-10): (50-100) is by volatile argyi leaf oil, soybean lecithin, cholesterol and sodium taurocholate
Chloroform dissolution is added in mixing；
(5) rotary evaporation 1-2h under 30-50 DEG C of water-bath is revolved after being dried in vacuo 10-12h at room temperature after film forming with phosphate buffer
Turn to wash film；
(6) folium artemisiae argyi is obtained with filtering with microporous membrane and is waved with after ultrasonic cell disruptor ultrasound 5-10min under the conditions of ice-water bath
Hair oil liposome；
(7) it is added in aluminium powder water-soluble with the cetyl trimethylammonium bromide for the 1-2mol/L that aluminium powder mass ratio is 5:1-10:1
Liquid after ultrasonic disperse 20-30min, stirs 1-2h at room temperature, be filtered, washed, dry after obtain positively charged aluminium powder；
(8) positively charged aluminium powder is added to the water ultrasonic disperse 20-30min and forms aluminium powder dispersion liquid, by volatile argyi leaf oil rouge
Plastid is added to the water to obtain volatile argyi leaf oil liposome suspension, and volatile argyi leaf oil is added in aluminium powder dispersion liquid under agitation
In liposome suspension, vacuum drying 12-24h is obtained using volatile argyi leaf oil liposome as core, aluminium at 40-50 DEG C after standing 1-2h
Powder is the core-shell structure compound particle of shell,
(9) core-shell structure compound particle is mixed with sodium carbonate and is crushed up to functional powder.
10. a kind of preparation method of hydrogen manufacturing Chinese medicine package according to claim 8 or claim 9, characterized in that revolving speed when crushing is
300-500 turns/min, grinding time 5-10min, and the temperature of packaging by hot pressing is 250-300 DEG C.
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| CN111513386A (en) * | 2020-04-29 | 2020-08-11 | 马扬芝 | Health-care mask capable of resisting and killing virus |
| CN113332246A (en) * | 2021-05-17 | 2021-09-03 | 丽水市第二人民医院 | Five-color foot bath powder for treating insomnia |
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