CN109589353A - A kind of concocting method of the fleece-flower root - Google Patents
A kind of concocting method of the fleece-flower root Download PDFInfo
- Publication number
- CN109589353A CN109589353A CN201910065970.2A CN201910065970A CN109589353A CN 109589353 A CN109589353 A CN 109589353A CN 201910065970 A CN201910065970 A CN 201910065970A CN 109589353 A CN109589353 A CN 109589353A
- Authority
- CN
- China
- Prior art keywords
- fleece
- flower root
- mature vinegar
- decoction
- black soybean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of concocting methods of fleece-flower root, comprising the following steps: and fleece-flower root block, decoction of black soybean and mature vinegar are taken by weight 100:10:25, is mixed thoroughly, bored profit is after 0.5 hour, it Steam by water bath 16 hours, until juice is sucked, takes out, 60 DEG C of drying, both.The present invention makes prior art that fleece-flower root active principle content is increased by the improvement to processing procedure.The present invention is screened by many experiments, creative processes the fleece-flower root using decoction of black soybean and mature vinegar mixing, experiment discovery processes the fleece-flower root using decoction of black soybean and mature vinegar mixing, the content of Stilbene Glucoside can be retained to the greatest extent, and the optimised process for processing the fleece-flower root is selected by testing sieve are as follows: mature vinegar dosage is that the stilbene content that 25% processing can make to process in the fleece-flower root keeps 2.0%, achieves extraordinary unexpected technical effect.
Description
Technical field
The present invention relates to the prepared slices of Chinese crude drugs to process field, and in particular to a kind of concocting method of the fleece-flower root.
Background technique
The fleece-flower root is in lumps or irregular spindle, long 6~15cm.4~12cm of diameter.Surface rufous is reddish brown
Color, shrinkage is uneven, has shallow ridges, and have horizontally long hole skin sample protrusion and radicula trace.Weight, matter is solid, is not easily broken, the pale yellow palm fibre of section
Color or pale red brown show mealiness, and there are 4~11 similar round abnormal vascular bundles circular rows in skin zone, form Nanjing brocade shape decorative pattern, central woody part
Larger, some is in core.Fleece-flower root gas is micro-, mildly bitter flavor and it is sweet puckery.Nature and flavor: bitter, sweet, puckery, tepor.Channel tropism: liver, the heart, kidney channel.Function
Can: removing toxic substances, disappear carbuncle, preventing malaria, relax bowel and defecation.The major functions: being used for sore carbuncle, scrofula, rubella itch, chronic malaria body void, dry constipation of intestines.It processes
Turbid lipid-loweringing is changed in fleece-flower root nourishing liver and kidney afterwards, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.For blood deficiency chlorosis, dizziness and tinnitus, beard and hair is early
It is white, soreness and weakness of waist and knees, extremity numbness, metrorrhagia and metrostaxis leukorrhagia, hyperlipidemia.
The concocting method of the existing fleece-flower root is mainly decoction of black soybean, wine etc., be will lead in the fleece-flower root in existing concocting process
Stilbene Glucoside content be greatly lowered, reduce its later period drug effect, there are certain deficiencies.
Summary of the invention
Goal of the invention: it the purpose of the invention is to overcome defect existing in the prior art, proposes a kind of technique and sets
Meter rationally, can substantially retain effective component stilbene content, improve and guarantee its clinical efficacy the fleece-flower root processing side
Method.
Technical solution: in order to achieve the goal above, the invention adopts the above technical scheme:
The fleece-flower root is processed with toast using decoction of black soybean and mature vinegar, processes the fleece-flower root with toast method for optimization decoction of black soybean and mature vinegar, with
Mature vinegar dosage is as investigation factor, and using stilbene content as evaluation index, what processes with toast method to decoction of black soybean and mature vinegar
The influence of stilbene content in the tuber of multiflower knotweed processes the fleece-flower root with toast method and provides theoretical foundation for decoction of black soybean and mature vinegar.
Specific technical solution is as follows:
A kind of concocting method of the fleece-flower root, it the following steps are included:
Fleece-flower root block is taken, fermented bean drink is blackened and mature vinegar is mixed thoroughly, after bored profit a period of time, Steam by water bath to juice is sucked, it takes out,
It is dry.
Preferably, the concocting method of the above-described fleece-flower root, the wherein dosage of the fleece-flower root, decoction of black soybean and mature vinegar
Than are as follows: 100:10:5~50.
As particularly preferred scheme, the concocting method of the above-described fleece-flower root, the dosage of the fleece-flower root, decoction of black soybean and mature vinegar
Than are as follows: 100:10:25.
Preferably, the concocting method of the above-described fleece-flower root, bored profit time are 0.5~2h.Particularly preferred 0.5
Hour.
Preferably, the concocting method of the above-described fleece-flower root, it the following steps are included:
Fleece-flower root block, decoction of black soybean and mature vinegar are taken by weight 100:10:25, is mixed thoroughly, bored profit is after 0.5 hour, and Steam by water bath is extremely
Juice is sucked, and is taken out, 60 DEG C of drying, both.
Preferably, acetate concentration is 5% in mature vinegar, and mature vinegar dosage is 5%~50%, concocted time 16h.
The invention has the benefit that
The present invention is screened by many experiments, and creative processes the fleece-flower root, experiment hair using decoction of black soybean and mature vinegar mixing
The fleece-flower root is now processed using decoction of black soybean and mature vinegar mixing, the content of Stilbene Glucoside can be retained to the greatest extent,
And the optimised process for processing the fleece-flower root is selected by testing sieve are as follows: mature vinegar dosage is that 25% processing can make to process two in the fleece-flower root
Styrene glycosides content keeps 2.0%.Achieve extraordinary unexpected technical effect.
Detailed description of the invention
Fig. 1 mature vinegar dosage is to fleece-flower root decoction of black soybean and mature vinegar with the influence for processing stilbene content in concocting process.
Specific embodiment
Technical solution of the present invention is described in more detail with reference to the accompanying drawings and detailed description.
1 material
1.1 instrument
Agilent-1200 highly effective liquid phase chromatographic system (Anjelen Sci. & Tech. Inc)；BP211D electronic balance (Germany
Sai Duolisi group company)；Electric steamer (ZHEJIANG SUPOR CO.,LTD).
1.2 reagent
Reference substance Stibene-glucoside (National Institute for Food and Drugs Control, lot number: 111537-201605, content:
94.6%)；The six batches of fleece-flowers root (Nanjing Hai Yuan prepared slices of Chinese crude drugs Co., Ltd provides, lot number: 170601,170906,170701,
170902,171223,180602)；Other reagents are that analysis is pure.
2 methods and result
2.1 chromatographic condition
2.1.1 the content assaying method of Stibene-glucoside
Chromatographic column: C18Silane group silica gel chromatographic column (250mm × 4.6mm)；Mobile phase: acetonitrile-water (25: 75, v/v)；
Detection wavelength: 320nm；Column temperature: 30 DEG C, flow velocity: 1.0mL/min, sample volume: 10 μ L.
The preparation of 2.2 reference substance solutions
Take Stibene-glucoside reference substance appropriate, it is accurately weighed, add methanol dilution at concentration containing Stibene-glucoside be 2000 μ g/
ML to get.
The preparation of 2.3 test solutions
Precision claims coarse powder prepared fleece flower root 0.25g, sets in triangular flask, 20 times of 50% ethyl alcohol of volume of dosing material, impregnates
After 30min, ultrasonic extraction 60min at 40 DEG C, 0.45 μm of miillpore filter filtration takes subsequent filtrate according to chromatographic condition under " 2.1 " item
Sample introduction measures the content of Stibene-glucoside in 6 batches of fleece-flowers root respectively.
2.4 linear relationship
Precision pipettes Stibene-glucoside reference substance solution 1mL into 1mL, 2mL, 5mL, 10mL, 25mL volumetric flask, with flowing
Phase dilution shakes up at 2.0,1,0.4,0.2,0.08mg/mL Stibene-glucoside reference substance series standard solution, and filtration is pressed
" 2.1 " chromatographic condition precision draws 10 μ L sample introductions and measures Stibene-glucoside, and with concentration (C) for abscissa, peak area (A) is vertical sits
Mark, obtains equation through regression fit are as follows: A=125177.6C-16235.5 (r=0.9999).The result shows that in 80~2000 μ g/mL
Stibene-glucoside concentration and peak area linear relationship are good in concentration range.
3, decoction of black soybean and mature vinegar are the same as the toast processing fleece-flower root
Fleece-flower root decoction of black soybean and mature vinegar process concocting method together: taking about 250g fleece-flower root medicine materical crude slice, blacken beans 25g and non-same amount is old
Vinegar takes out after bored profit 30min, is added to steam and steams juice in container and be sucked, after take out 60 DEG C of drying, crushed 80
Mesh, it is spare.
4, the single factor experiment that decoction of black soybean and mature vinegar process fleece-flower root technique with toast is investigated
Preliminary result early period of the invention shows to influence the principal element that decoction of black soybean and mature vinegar process fleece-flower root technique with toast
For mature vinegar dosage, therefore the present invention chooses 4 levels of mature vinegar dosage (0%, 5%, 25%, 50%), is obtained by single factor exploration
Fleece-flower root process parameters range is processed with toast to more suitable decoction of black soybean and mature vinegar.
The screening of 4.1 mature vinegar dosages
Concocted time is fixed as 16h, and acetate concentration is 5% in mature vinegar, and mature vinegar dosage selects 0%, 5%, 25% respectively,
50% 4 horizontal decoction of black soybean and mature vinegar handle sample according to test sample dissolution method under " 2.3 " item, and press with the toast processing fleece-flower root
The content that Stibene-glucoside in the fleece-flower root is measured according to chromatographic condition difference sample introduction under " 2.1 " item, the results are shown in Table 1.
Table 1 is different plus vinegar amount influences stilbene content in the fleece-flower root
| Add vinegar amount (%) | Stibene-glucoside average content (%) |
| Health product | 1.995 |
| 0 | 1.448 |
| 5 | 1.727 |
| 25 | 2.000 |
| 50 | 1.905 |
By 1 experimental result of table it is found that concocted time under the same conditions, mature vinegar dosage is to fleece-flower root decoction of black soybean and mature vinegar
Content with Stibene-glucoside in toast concocting process has and significantly affects, with the increase of mature vinegar dosage, hexichol in concocting process
Ethylene glycosides content is in decreasing trend after first increasing.
As can be known from Table 1, mature vinegar dosage contains fleece-flower root decoction of black soybean with mature vinegar with Stibene-glucoside in toast concocting process
Amount influences more significant.And by Fig. 1 result it is found that with mature vinegar dosage raising, stilbene content reaches afterwards in first increasing
To stable tendency, and add the other stilbene content of vinegar processing group much larger than vinegar processing group is not added, especially 25% adds vinegar
Amount processing group is even higher than health product group, therefore the concocting method of the present invention preferably 25% plus vinegar amount.
The foregoing is only a preferred embodiment of the present invention, the scope of protection of the present invention is not limited to this, it is any ripe
Know those skilled in the art within the technical scope of the present disclosure, the letter for the technical solution that can be become apparent to
Altered or equivalence replacement are fallen within the protection scope of the present invention.
Claims (6)
1. a kind of concocting method of the fleece-flower root, which is characterized in that it the following steps are included:
Fleece-flower root block is taken, fermented bean drink is blackened and mature vinegar is mixed thoroughly, after bored profit a period of time, Steam by water bath to juice is sucked, and is taken out, and is done
It is dry.
2. the concocting method of the fleece-flower root according to claim 1, which is characterized in that the use of the fleece-flower root, decoction of black soybean and mature vinegar
Measure ratio are as follows: 100:10:5~50.
3. the concocting method of the fleece-flower root according to claim 2, which is characterized in that the use of the fleece-flower root, decoction of black soybean and mature vinegar
Measure ratio are as follows: 100:10:25.
4. the concocting method of described in any item fleece-flowers root according to claim 1~3, which is characterized in that acetate concentration in mature vinegar
It is 5%.
5. the concocting method of the fleece-flower root according to claim 4, which is characterized in that the bored profit time is 0.5~2h.
6. the concocting method of the fleece-flower root according to claim 1, which is characterized in that it the following steps are included:
Fleece-flower root block, decoction of black soybean and mature vinegar are taken by weight 100:10:25, is mixed thoroughly, bored profit is after 0.5 hour, and Steam by water bath 16 hours,
It is sucked, takes out to juice, 60 DEG C of drying, both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910065970.2A CN109589353A (en) | 2019-01-24 | 2019-01-24 | A kind of concocting method of the fleece-flower root |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910065970.2A CN109589353A (en) | 2019-01-24 | 2019-01-24 | A kind of concocting method of the fleece-flower root |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109589353A true CN109589353A (en) | 2019-04-09 |
Family
ID=65964726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910065970.2A Pending CN109589353A (en) | 2019-01-24 | 2019-01-24 | A kind of concocting method of the fleece-flower root |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109589353A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114736109A (en) * | 2022-03-02 | 2022-07-12 | 华南理工大学 | Method for selectively extracting stilbene glycoside component from Polygoni Multiflori radix |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793756A (en) * | 2012-08-01 | 2012-11-28 | 亳州市国一堂中药饮片有限公司 | Preparation process of polygonum multiflorum medicinal slices |
| CN103623070A (en) * | 2013-04-02 | 2014-03-12 | 汕头市创美中药饮片有限公司 | Processing production technology for polygonum multiflorum |
| CN105395623A (en) * | 2015-11-23 | 2016-03-16 | 北京康仁堂药业有限公司 | A processing technology of prepared fleeceflower root |
| CN105663274A (en) * | 2016-03-03 | 2016-06-15 | 安徽逸峰制药有限公司 | Preparation method of fleece-flower root |
| CN107041903A (en) * | 2016-02-05 | 2017-08-15 | 中国中医科学院中药研究所 | Prepared fleece flower root Habitat producing processes integrated new method |
| CN108159131A (en) * | 2018-03-19 | 2018-06-15 | 北京杏林药业有限责任公司 | A kind of polygonum multiflorum processing technology |
| CN108670984A (en) * | 2018-06-16 | 2018-10-19 | 禹州市厚生堂中药有限公司 | A kind of processing procedure of seed fruit class pharmaceutical decocting piece |
-
2019
- 2019-01-24 CN CN201910065970.2A patent/CN109589353A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793756A (en) * | 2012-08-01 | 2012-11-28 | 亳州市国一堂中药饮片有限公司 | Preparation process of polygonum multiflorum medicinal slices |
| CN103623070A (en) * | 2013-04-02 | 2014-03-12 | 汕头市创美中药饮片有限公司 | Processing production technology for polygonum multiflorum |
| CN105395623A (en) * | 2015-11-23 | 2016-03-16 | 北京康仁堂药业有限公司 | A processing technology of prepared fleeceflower root |
| CN107041903A (en) * | 2016-02-05 | 2017-08-15 | 中国中医科学院中药研究所 | Prepared fleece flower root Habitat producing processes integrated new method |
| CN105663274A (en) * | 2016-03-03 | 2016-06-15 | 安徽逸峰制药有限公司 | Preparation method of fleece-flower root |
| CN108159131A (en) * | 2018-03-19 | 2018-06-15 | 北京杏林药业有限责任公司 | A kind of polygonum multiflorum processing technology |
| CN108670984A (en) * | 2018-06-16 | 2018-10-19 | 禹州市厚生堂中药有限公司 | A kind of processing procedure of seed fruit class pharmaceutical decocting piece |
Non-Patent Citations (1)
| Title |
|---|
| 聂砚田: "中药炮制常用辅料及其临床应用 ", 《中国药物经济学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114736109A (en) * | 2022-03-02 | 2022-07-12 | 华南理工大学 | Method for selectively extracting stilbene glycoside component from Polygoni Multiflori radix |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2307273C (en) | Method and apparatus for making herbal extracts using percolation | |
| CN106018629B (en) | A kind of japanese fleeceflower leaf finger-print HPLC method and its application in the control of japanese fleeceflower leaf capsule quality | |
| CN105353063B (en) | Compound cold drug stream livering ingredient standard finger-print and construction method, application | |
| CN109589353A (en) | A kind of concocting method of the fleece-flower root | |
| CN113376273B (en) | Detection method of HPLC (high performance liquid chromatography) characteristic spectrum of Qingxin lotus seed drink and application of characteristic spectrum | |
| CN106668235A (en) | Seedless roxburgh rose general flavone, as well as preparation method and application thereof | |
| CN109932453A (en) | A kind of detection method of radix saposhnikoviae | |
| CN101543545B (en) | Traditional Chinese medicine preparation for curing rhinitis and quality control method thereof | |
| CN108663440A (en) | Callicarpa nudiflora medicinal material UPLC fingerprint map constructions method and standard finger-print | |
| CN113509523A (en) | Processing method and application of steamed polygonatum sibiricum | |
| CN110346494B (en) | Method for simultaneously measuring contents of 4 effective components in erigeron breviscapus | |
| CN105147745B (en) | A kind of processing procedure and application thereof of Tibetan medicine medicine materical crude slice euphorbiae fischerianae myrobalan | |
| CN102485240A (en) | Fleece-flower root particulate agent and its preparation method | |
| CN114392290A (en) | Ginseng drying processing method | |
| CN109394806B (en) | Processing method of ginseng and polygonatum odoratum | |
| CN104458954A (en) | Semen cuscutae formula particle fingerprint spectrum and building method thereof | |
| CN107961321A (en) | A kind of extraction process of six directions pellet bulk pharmaceutical chemicals | |
| CN101791358B (en) | Method for measuring content of icariin in wolfberry fruit and broomrape tablets | |
| Wu et al. | Correlation between 5-hydroxymethylfurfural content and color of Rehmanniae Radix and Rehmanniae Radix Praeparata. | |
| CN104840625A (en) | Liver-protecting pharmaceutical composition, and preparation method and use thereof | |
| CN109106823A (en) | A kind of concocting method of rhizoma alismatis | |
| CN105055541B (en) | The preparation process of compound polygonum flaccidum Chinese herbal medicine fluid body preparation | |
| CN115381014A (en) | Hangover-alleviating and liver-protecting functional solid beverage | |
| CN110426475B (en) | Detection method of health-care herbal tea | |
| CN114791472B (en) | Method for detecting components of spray for dispelling wind and activating collaterals |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190409 |
|
| RJ01 | Rejection of invention patent application after publication |