CN109106823A - A kind of concocting method of rhizoma alismatis - Google Patents
A kind of concocting method of rhizoma alismatis Download PDFInfo
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Abstract
The present invention relates to Chinese medicine processing technique field, in particular to a kind of concocting method of rhizoma alismatis；Pass through 2 bored profits, bored profit uses distilled water for the first time, soften rhizoma alismatis crude drug, be conducive to cutting medicine materical crude slice, the bored profit of sodium chloride solution is used in second of bored profit, make in salt penetration to rhizoma alismatis medicine materical crude slice, frying is carried out after secondary bored profit, be conducive to inducting the medicines into affected channel, toxic side effect can also be effectively reduced, in rhizoma alismatis concocting method of the present invention, the temperature and time of 2 bored profits, the temperature and time parameter of frying is very fastidious, the too high or too low comprehensive score that can all influence medicinal material finished product, the comprehensive score of Rhizoma Alismatis finished product made from rhizoma alismatis concocting method of the invention is up to 98.45, sufficiently meet version " Chinese Pharmacopoeia " requirement to stir-baked RHIZOMA ALISMATIS with salt solution character in 2015, apparent reducing blood lipid can be played, it is hypoglycemic, anti-calculus, diuresis, anti-inflammatory and buck functionality.
Description
Technical field
The present invention relates to Chinese medicine processing technique field, in particular to a kind of concocting method of rhizoma alismatis.
Background technique
With the implementation of " People's Republic of China's traditional Chinese medicine method ", organized by National Development and Reform Committee and State Administration of Traditional Chinese Medicine
The national Chinese medicine standardization project of implementation, key task are to produce full mistake for Chinese medicine plantation, Manufacture of medicinal slices of TCM, Chinese patent drug
The technical specification and shortage of standard problem of journey put forth effort on the technical specification optimization that Chinese medicine produces each link, to the raising prepared slices of Chinese crude drugs
And products thereof quality and curative effect have very big impetus；Meanwhile medicine materical crude slice standardized production " plants promotion Chinese Medicine Industry
Medicine has produced medicine, has made medicine " it is of great significance.
In more than 100 a prepared slices of Chinese crude drugs kinds of this construction, Fujian Province genunie medicinal materials rhizoma alismatis is selected kind, the medicinal material
With drug effects such as lipid-loweringing, hypoglycemic, blood pressure lowering, diuresis, antitumor, anti-inflammatory and anti-fatty livers.Versions " Chinese Pharmacopoeia " in 2015 and more
Ground concocted specification is on the books to rhizoma alismatis processed product (stir-baked RHIZOMA ALISMATIS with salt solution), but the quantization parameter of links does not refine, area and enterprise
Between stir-baked RHIZOMA ALISMATIS with salt solution technique difference it is larger, it is therefore necessary to rhizoma alismatis salt technique links carry out system thinking, constituting criterion
The production specification of change.Currently, there are reports for the research in relation to rhizoma alismatis processing procedure, but laboratory lab scale is all made of to complete
Technique is groped, and cannot be reflected standardized production completely and be produced the concrete condition of links parameter under grade equipment；Process work
Skill evaluation index selects more single (being triterpenes).In addition to triterpene in rhizoma alismatis modern chemistry and pharmaceutical research discovery rhizoma alismatis
Outside constituents, sesquiterpenoids is also its important effective substance, but at present in document processing procedure to Sesquiterpene Polyesterss
Influence but rarely has research.
This experiment according to Chinese medicine standardization project detailed rules for the implementation requirement, in pilot scale grade equipment using single factor experiment and
Orthogonal test studies each key link of rhizoma alismatis process of preparing, including rhizoma alismatis slice, processing aids dosage, processing temperature
The production links such as degree, frying time.Using sequiterpene, triterpene, ethanol soluble extractives and appearance character as overall target, optimization salt pool
The processing procedure rushed down, it is intended to establish rhizoma alismatis high-quality medicine materical crude slice production and processing concocted specification, be the full industrial chain mass transfer of Chinese medicine and excellent
The standard formulation of the matter prepared slices of Chinese crude drugs provides foundation.
Summary of the invention
The technical problems to be solved by the present invention are: provide it is a kind of can play apparent reducing blood lipid, hypoglycemic, anti-calculus,
Diuresis, anti-inflammatory and buck functionality Rhizoma Alismatis concocting method.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention are as follows: a kind of concocting method of rhizoma alismatis, including with
Lower step:
Step 1: by rhizoma alismatis crude drug, bored profit 1-2h, the bored profit temperature are 70-80 DEG C in distilled water；
Step 2: the rhizoma alismatis Jing Guo bored profit being cut in 70-80 DEG C, rhizoma alismatis slice, the thickness of the rhizoma alismatis slice is made
Degree is 3-5mm；
Step 3:, in 60-70 DEG C of dry 1-3h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 2.5-3.5h, the bored profit temperature are 70-80 DEG C in sodium chloride solution；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 7-9min at 150-170 DEG C, Rhizoma Alismatis is made
Finished product.
The beneficial effects of the present invention are: a kind of rhizoma alismatis concocting method provided by the invention is bored for the first time by 2 bored profits
Profit uses distilled water, softens rhizoma alismatis crude drug, is conducive to cutting medicine materical crude slice, uses the bored profit of sodium chloride solution in second of bored profit,
Make in salt penetration to rhizoma alismatis medicine materical crude slice, carry out frying after secondary bored profit, be conducive to inducting the medicines into affected channel, moreover it is possible to malicious secondary work be effectively reduced
With in rhizoma alismatis concocting method of the present invention, the temperature and time of 2 bored profits, the temperature and time parameter of frying are extremely examined
Study carefully, the too high or too low comprehensive score that can all influence medicinal material finished product, Rhizoma Alismatis made from rhizoma alismatis concocting method of the invention at
The comprehensive score of product is up to 98.45, sufficiently meets version " Chinese Pharmacopoeia " requirement to stir-baked RHIZOMA ALISMATIS with salt solution character in 2015, can play bright
Aobvious reducing blood lipid, hypoglycemic, anti-calculus, diuresis, anti-inflammatory and buck functionality.
Detailed description of the invention
Fig. 1 be the specific embodiment of the invention in liquid chromatography assay in reference substance and test sample each ingredient chromatographic peak
Figure；
Specific embodiment
To explain the technical content, the achieved purpose and the effect of the present invention in detail, below in conjunction with embodiment and cooperate attached
Figure is explained.
The most critical design of the present invention is: bored profit uses distilled water for the first time by 2 bored profits, keep rhizoma alismatis crude drug soft
Change, be conducive to cutting medicine materical crude slice, uses the bored profit of sodium chloride solution in second of bored profit, make in salt penetration to rhizoma alismatis medicine materical crude slice, two
Frying is carried out after secondary bored profit, is conducive to inducting the medicines into affected channel, moreover it is possible to toxic side effect be effectively reduced.
Fig. 1 is please referred to, the present invention relates to a kind of concocting methods of rhizoma alismatis, comprising the following steps:
Step 1: by rhizoma alismatis crude drug, bored profit 1-2h, the bored profit temperature are 70-80 DEG C in distilled water；
Step 2: the rhizoma alismatis Jing Guo bored profit being cut in 70-80 DEG C, rhizoma alismatis slice, the thickness of the rhizoma alismatis slice is made
Degree is 3-5mm；
Step 3:, in 60-70 DEG C of dry 1-3h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 2.5-3.5h, the bored profit temperature are 70-80 DEG C in sodium chloride solution；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 7-9min at 150-170 DEG C, Rhizoma Alismatis is made
Finished product.
Above-mentioned rhizoma alismatis concocting method is by 2 bored profits, and bored profit uses distilled water for the first time, softens rhizoma alismatis crude drug, favorably
In cutting medicine materical crude slice, the bored profit of sodium chloride solution is used in second of bored profit, is made in salt penetration to rhizoma alismatis medicine materical crude slice, after secondary bored profit
Frying is carried out, inducting the medicines into affected channel is conducive to, moreover it is possible to be effectively reduced toxic side effect, in rhizoma alismatis concocting method of the present invention, 2 times bored
The temperature and time of profit, the temperature and time parameter of frying are very fastidious, the too high or too low synthesis that can all influence medicinal material finished product
It scores, the comprehensive score of Rhizoma Alismatis finished product made from rhizoma alismatis concocting method of the invention is up to 98.45, sufficiently meets 2015
Requirement of the version " Chinese Pharmacopoeia " to stir-baked RHIZOMA ALISMATIS with salt solution character can play apparent reducing blood lipid, hypoglycemic, anti-calculus, diuresis, anti-inflammatory and drop
Press function.
Further, in the step 4 of the concocting method of above-mentioned rhizoma alismatis, the concentration of sodium chloride solution is 11%-
25%.
Further, in the step 4 of the concocting method of above-mentioned rhizoma alismatis, the quality of the sodium chloride solution is rhizoma alismatis drink
The 13%-16% of tablet quality.
Further, in the step 4 of the concocting method of above-mentioned rhizoma alismatis, the concentration of the sodium chloride solution is 13%,
The quality of the sodium chloride solution is the 15% of rhizoma alismatis prepared slice quality.
Further, in the step 1 of the concocting method of above-mentioned rhizoma alismatis, the bored profit time is 1.5h, the bored profit temperature
It is 75 DEG C, the quality of the distilled water is the 18% of rhizoma alismatis crude drug quality.
Further, in the step 2 of the concocting method of above-mentioned rhizoma alismatis,
The cutting temperature of the rhizoma alismatis is 75 DEG C.
Further, the drying temperature of rhizoma alismatis is 65 DEG C in the step 3 of the concocting method of above-mentioned rhizoma alismatis, drying time
For 2h.
Further, the frying temperature of the rhizoma alismatis medicine materical crude slice of the concocting method of above-mentioned rhizoma alismatis is 160 DEG C, and the frying time is
7-9min。
Embodiment 1
A kind of concocting method of rhizoma alismatis, comprising the following steps:
Step 1: by rhizoma alismatis crude drug, bored profit 1.5h, the bored profit temperature are 75 DEG C in distilled water；The matter of the distilled water
Amount is the 18% of rhizoma alismatis crude drug quality；
Step 2: the rhizoma alismatis Jing Guo bored profit being cut in 70-80 DEG C, rhizoma alismatis slice, the thickness of the rhizoma alismatis slice is made
Degree is 4mm；
Step 3:, in 65 DEG C of dry 2h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 3h, the bored profit temperature are 75 DEG C in sodium chloride solution；The sodium chloride is molten
The concentration of liquid is 13%, and the quality of the sodium chloride solution is the 15% of rhizoma alismatis prepared slice quality；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 8min at 160 DEG C, Rhizoma Alismatis finished product is made.
Embodiment 2
A kind of concocting method of rhizoma alismatis, comprising the following steps:
Step 1: by rhizoma alismatis crude drug, bored profit 1h, the bored profit temperature are 70 DEG C in distilled water；The quality of the distilled water
It is the 18% of rhizoma alismatis crude drug quality；
Step 2: the rhizoma alismatis Jing Guo bored profit being cut in 70 DEG C, rhizoma alismatis slice, the thickness of the rhizoma alismatis slice is made
For 3mm；
Step 3:, in 60 DEG C of dry 1h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 2.5h, the bored profit temperature are 70 DEG C in sodium chloride solution；The sodium chloride
The concentration of solution is 11%%, and the quality of the sodium chloride solution is the 13%% of rhizoma alismatis prepared slice quality；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 7min at 150 DEG C, Rhizoma Alismatis finished product is made.
Embodiment 3
A kind of concocting method of rhizoma alismatis, comprising the following steps:
Step 1: by rhizoma alismatis crude drug, bored profit 2h, the bored profit temperature are 80 DEG C in distilled water；The quality of the distilled water
It is the 18% of rhizoma alismatis crude drug quality；
Step 2: the rhizoma alismatis Jing Guo bored profit being cut in 80 DEG C, rhizoma alismatis slice, the thickness of the rhizoma alismatis slice is made
For 5mm；
Step 3:, in 70 DEG C of dry 3h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 3.5h, the bored profit temperature are 80 DEG C in sodium chloride solution；The sodium chloride
The concentration of solution is 25%, and the quality of the sodium chloride solution is the 16% of rhizoma alismatis prepared slice quality；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 9min at 170 DEG C, Rhizoma Alismatis finished product is made.
For the Rhizoma Alismatis finished product made from a kind of concocting method of rhizoma alismatis of embodiment 1, multi-target ingredient is carried out
Chromatography；
Chromatographic condition is as follows:
ACQUITY UPLC BEH C18 chromatographic column (2.1mm × 100mm, 1.7 μm), mobile phase acetonitrile (A)-water (B) ladder
Degree elution (0~0.2min, 35%A；0.2~2.5min, 35%~55%A；2.5~3.5 min, 55%A；3.5~
6.5min, 55%~73%A；6.5~9.5min, 73%~87%A；9.5~11min, 87%A), 40 DEG C of column temperature, flow velocity
0.35mLmin-1, sample volume 2 μ L, Detection wavelength 208nm.Point of 5 reference substances and other chromatographic peaks under this chromatographic condition
> 1.5 from degree, number of theoretical plate is equal > and 3 000, chromatographic peak is well-symbolized, sees Fig. 1；Wherein, A is reference substance；B is test sample；1
For alismoxide；2 be 23- acetylalisol C；3 be rhizoma alismatis enol；4 be alisol B；5 be Alisol B monoacetate；
The preparation of reference substance solution:
Precision weighs alismoxide, 23- acetylalisol C, rhizoma alismatis enol, alisol B and Alisol B monoacetate pair
Appropriate according to product, respectively plus pair that mass concentration is 1.201,1.021,1.009,0.997,0.919gL-1 is made in 50% acetonitrile
According to product mother liquor.
The preparation of test solution:
Precision weighs Oriental Waterplantain Rhizome (crossing No. five sieves) 1.0g, sets in 50mL stuffed conical flask, acetonitrile 25mL is added in precision, close
Plug, weighed quality are ultrasonically treated (power 250W, frequency 50kHz) 30min, let cool, weighed quality adds acetonitrile to supply less loss
Quality shakes up, and extracting solution is centrifuged 10 min in 10,000 rmin-1, filters through 0.22 μm of miillpore filter, take subsequent filtrate to get.
Linear relationship is investigated:
Precision draws alismoxide, 23- acetylalisol C, rhizoma alismatis enol, alisol B and Alisol B monoacetate pair
It is appropriate according to product mother liquor, add 50% acetonitrile that mixed reference substance solution is made, mixed reference substance solution is diluted to serial mixing step by step
Reference substance solution is measured by above-mentioned chromatographic condition, makees linear regression with peak area (Y) and analyte mass concentration (X), as a result see
Table 1.
The regression equation of 5 index components in 1 rhizoma alismatis of table
Precision test:
Precision draws same mixed reference substance solution, by above-mentioned chromatographic condition replication 6 times, calculates alismoxide,
The RSD of 23- acetylalisol C, rhizoma alismatis enol, alisol B and Alisol B monoacetate peak area is respectively 1.4%, 0.8%,
0.5%, 1.5% and 1.3%, show that the instrument precision is good.
Stability test:
It takes with a 6 parts of test solution of stir-baked RHIZOMA ALISMATIS with salt solution, respectively at 0,2,6,10,12, is measured for 24 hours by above-mentioned chromatographic condition,
RSD points of calculating alismoxide, 23- acetylalisol C, rhizoma alismatis enol, alisol B and 23- acetylalisol B peak area
Not Wei 1.5%, 1.1%, 1.2%, 0.7% and 0.8%, show that test solution is good in internal stability for 24 hours.
Repetitive test:
Precision is weighed with a 6 parts of powder of stir-baked RHIZOMA ALISMATIS with salt solution test sample, prepares test solution, is measured by above-mentioned chromatographic condition,
Calculate alismoxide, 23- acetylalisol C, rhizoma alismatis enol, the average mass fraction of alisol B and Alisol B monoacetate
Respectively 0.003%, 0.02%, 0.03%, 0.05% and 0.11%, RSD is respectively 2.4%, 1.5%, 1.7%, 1.6%
With 1.7%, show that this method repeatability is good.
It is loaded recovery test:
Precision weighs the stir-baked RHIZOMA ALISMATIS with salt solution medicine materical crude slice powder of index components content known to 6 parts, and (rhizoma alismatis processing procedure single factor experiment is examined
The bored profit time is 1h in examining) 0.5g, it is accurate respectively that a certain amount of mixed reference substance solution is added, test sample is prepared according to the above method
Solution is measured by above-mentioned chromatographic condition, calculates alismoxide, 23- acetylalisol C, rhizoma alismatis enol, alisol B and 23- second
The mean sample recovery rate of acyl alisol B is respectively 98.48%, 98.57%, 97.92%, 100.13% and 99.66%, RSD
Respectively 2.6%, 1.4%, 2.3%, 2.0% and 2.5%, show that this method is accurate and reliable.
Sample measurement:
Precision weighs the Rhizoma Alismatis finished product that embodiment 1 obtains, 1.0g, according to the method described above squeezing cup test solution,
It is measured by above-mentioned chromatographic condition, the content of each index components is calculated according to external standard method.
Testing result:
The mass fraction of alismoxide is 0.039mg/g；The mass fraction of 23- acetylalisol C is 0.147mg/g；
The mass fraction of rhizoma alismatis enol is 0.362mg/g；The mass fraction of alisol B is 0.464mg/g；Alisol B monoacetate
Mass fraction is 1.392mg/g.
For the Rhizoma Alismatis finished product made from a kind of concocting method of rhizoma alismatis of embodiment 1, ethanol soluble extractives are carried out
Assay, the method is as follows:
Precision weighs rhizoma alismatis and stir-baked RHIZOMA ALISMATIS with salt solution sample powder 2.0g, sets in 100mL conical flask, and 95% ethyl alcohol is added in precision
75mL, close plug, weighed quality connect reflux condensing tube after standing 1h, are heated to boiling, and keep slightly boiled 1h.It is removed after letting cool
Conical flask, close plug, then weighed quality, the quality of less loss is supplied with 95% ethyl alcohol, is shaken up, and filtration, precision measures filtrate 25mL, is set
It has dried into the evaporating dish of constant weight, in 105 DEG C of dry 3h after water bath method, has set cooling 30min in drier, it is accurate rapidly to claim
Determine quality, calculate the content of ethanol soluble extractives, the mass fraction of finally obtained ethanol soluble extractives is 18.37%.
For the Rhizoma Alismatis finished product made from a kind of concocting method of rhizoma alismatis of embodiment 1, sense organ comprehensive score is carried out,
Standards of grading are as follows:
The total amount combination ethanol soluble extractives content and appearance character of 5 using in stir-baked RHIZOMA ALISMATIS with salt solution ingredients refer to as overall merit
Mark, wherein total content and ethanol soluble extractives content are the inherent indexs of stir-baked RHIZOMA ALISMATIS with salt solution, and appearance character is external index.Referring to 2015
Requirement of the year version " Chinese Pharmacopoeia " to stir-baked RHIZOMA ALISMATIS with salt solution character, evaluates appearance character total score in terms of color, quality, smell 3.Using comprehensive
Close the processing procedure of the preferred stir-baked RHIZOMA ALISMATIS with salt solution of method of weighting scores, total amount, ethanol soluble extractives content and the appearance character of 5 index components
Weight coefficient be respectively 0.50,0.35,0.15.
In Rhizoma Alismatis finished product made from embodiment 1, color is faint yellow or yellowish-brown, and quality is solid, accidental focal spot, gas
Micro-, taste is micro- salty, and comprehensive score is up to 98.45.
In conclusion a kind of rhizoma alismatis concocting method provided by the invention is by 2 bored profits, bored profit is using distillation for the first time
Water softens rhizoma alismatis crude drug, is conducive to cutting medicine materical crude slice, uses the bored profit of sodium chloride solution in second of bored profit, makes salt penetration extremely
In rhizoma alismatis medicine materical crude slice, frying is carried out after secondary bored profit, is conducive to inducting the medicines into affected channel, moreover it is possible to toxic side effect be effectively reduced, the present invention relates to
And rhizoma alismatis concocting method in, the temperature and time of 2 bored profits, the temperature and time parameter of frying are very fastidious, excessively high or mistake
The low comprehensive score that can all influence medicinal material finished product, the comprehensive score of Rhizoma Alismatis finished product made from rhizoma alismatis concocting method of the invention
Up to 98.45, sufficiently meet version " Chinese Pharmacopoeia " requirement to stir-baked RHIZOMA ALISMATIS with salt solution character in 2015, apparent reducing blood lipid, drop can be played
Blood glucose, anti-calculus, diuresis, anti-inflammatory and buck functionality.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalents made by bright specification and accompanying drawing content are applied directly or indirectly in relevant technical field, similarly include
In scope of patent protection of the invention.
Claims (8)
1. a kind of concocting method of rhizoma alismatis, which comprises the following steps:
Step 1: by rhizoma alismatis crude drug, bored profit 1-2h, the bored profit temperature are 70-80 DEG C in distilled water；
Step 2: the rhizoma alismatis Jing Guo bored profit is cut in 70-80 DEG C, is made rhizoma alismatis slice, rhizoma alismatis slice with a thickness of
3-5mm；
Step 3:, in 60-70 DEG C of dry 1-3h, rhizoma alismatis medicine materical crude slice will be obtained by the rhizoma alismatis of slice；
Step 4: by rhizoma alismatis medicine materical crude slice, bored profit 2.5-3.5h, the bored profit temperature are 70-80 DEG C in sodium chloride solution；
Step 5: the rhizoma alismatis medicine materical crude slice by bored profit is cooling after frying 7-9min at 150-170 DEG C, Rhizoma Alismatis finished product is made.
2. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that in the step 4, sodium chloride solution it is dense
Degree is 11%-25%.
3. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that in the step 4, the sodium chloride solution
Quality be rhizoma alismatis prepared slice quality 13%-16%.
4. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that in the step 4, the sodium chloride solution
Concentration be 13%, the quality of the sodium chloride solution is the 15% of rhizoma alismatis prepared slice quality.
5. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that in the step 1, the bored profit time is
1.5h, the bored profit temperature are 75 DEG C, and the quality of the distilled water is the 18% of rhizoma alismatis crude drug quality.
6. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that in the step 2, the cutting of the rhizoma alismatis
Temperature is 75 DEG C.
7. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that the drying temperature of rhizoma alismatis in the step 3
It is 65 DEG C, drying time 2h.
8. the concocting method of rhizoma alismatis according to claim 1, which is characterized in that the frying temperature of the rhizoma alismatis medicine materical crude slice is
160 DEG C, the frying time is 7-9min.
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