CN109588559A - The application of ethyl pyruvate and feed - Google Patents
The application of ethyl pyruvate and feed Download PDFInfo
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- CN109588559A CN109588559A CN201910082949.3A CN201910082949A CN109588559A CN 109588559 A CN109588559 A CN 109588559A CN 201910082949 A CN201910082949 A CN 201910082949A CN 109588559 A CN109588559 A CN 109588559A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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Abstract
The present invention discloses application and the feed of a kind of ethyl pyruvate, is related to livestock and poultry cultivation technical field.The application of application and ethyl pyruvate in animal feed the invention particularly discloses ethyl pyruvate as the feed addictive with antibacterial growth promotion.The invention also provides a kind of feeds, including ethyl pyruvate.In technical solution provided by the invention, ethyl pyruvate is as the feed addictive with antibacterial growth promotion, with high security, the advantages of having no drug resistance, feeding antibiotic can effectively be substituted, meet healthy aquaculture developing direction, it can be used for preventing and treating the disease as caused by Escherichia coli, Sharpe door bacterium, staphylococcus aureus and streptococcus pneumonia, by inhibiting the breeding of animal intestinal tract harmful microbe, and then promote the incidence of growth of animal, disease of improving food conversion ratio, reduce.
Description
Technical field
The present invention relates to livestock and poultry cultivation technical field, in particular to the application of a kind of ethyl pyruvate and feed.
Background technique
Antibiotic is still treatment animal and mankind's disease in 21 century as one of 20th century most important medical discovery
The basic means of disease.Antibiotic is used to livestock and poultry, primarily to prevention disease and enhancing development, it is raw to have become herding
Indispensable additive in production.However, existing conclusive evidence show abuse of antibiotics will lead to bacterial pathogen generate it is general
Time drug resistance and pharmacological property residual, and then endanger the health of eater.Agricultural rural area portion, China announces will be comprehensive in the year two thousand twenty
The use for forbidding feeding antibiotic, the antiseptic feed additive for finding new type of safe replace antibiotic, ask at urgently to be resolved
Topic.
Substitutes For Antibiotic common at present has probiotics, plant extracts (plants essential oil), acidulant etc., but deposits
In many defects: microorganism formulation requires height to environmental condition, and vulnerable to loss during feed processing, stability is not strong；It plants
Object extract (plants essential oil) complicated component, production technology are not perfect, it is difficult to standardize and using effect is unstable；Acidulant needle
Not strong to property, palatability is also poor.
Summary of the invention
The main object of the present invention is application and the feed for proposing a kind of ethyl pyruvate, it is intended to which open ethyl pyruvate is made
To have effects that the application of the feed addictive of antibacterial growth promotion, have the function of substitute antibiotics.
It is an object of the present invention to propose a kind of ethyl pyruvate as the feed with antibacterial growth promotion to add
Add the application of agent.
The second object of the present invention is to propose a kind of application of ethyl pyruvate in animal feed, which is characterized in that
It is added in animal feed as the feed addictive with antibacterial growth promotion.
Preferably, the animal feed is pannage, ox feed, sheep feed, chicken feed, duck feed, horse feed, rabbit feed
Or fish meal.
Preferably, the ethyl pyruvate is added to livestock and poultry directly as the feed addictive with antibacterial growth promotion
Or in aquatic animal feed.
Preferably, the premix that the ethyl pyruvate and feed addictive or feedstuff are mixed is added to poultry
In fowl or aquatic animal feed；And/or
The concentrate feed that the ethyl pyruvate and feed addictive or feedstuff are mixed is added to livestock and poultry or water
It produces in animal feed.
Preferably, the pre-mixing agent that the ethyl pyruvate and carrier are mixed is added to livestock and poultry or aquatic animal feed
In.
It preferably, then will be made of the pre-mixing agent after the ethyl pyruvate and carrier being mixed and made into pre-mixing agent
Premix is added in livestock and poultry or aquatic animal feed；And/or
After the ethyl pyruvate and carrier are mixed and made into pre-mixing agent, then concentrate feed made of the pre-mixing agent is added
It is added in livestock and poultry or aquatic animal feed.
Preferably, the additive amount of the ethyl pyruvate is the 0.002~0.5% of animal feed total weight.
In addition, the feed includes ethyl pyruvate the invention also provides a kind of feed.
Preferably, the ethyl pyruvate accounts for the 0.002~0.5% of the feed relative；And/or
The animal feed is that pannage, ox feed, sheep feed, chicken feed, duck feed, horse feed, rabbit feed or fish are raised
Material.
In technical solution provided by the invention, inventor has found growth of the ethyl pyruvate to Escherichia coli and salmonella
Have an obvious inhibiting effect, and its metabolite in vivo is the main intermediate product pyruvic acid of human body energy metabolism, to people and
Animal body without obvious toxic-side effects, have noresidue, have no drug resistance, safety is good, palatability is good and antibacterial growth-promoting effect
Good advantage.Meanwhile ethyl pyruvate mature preparation process, property are stablized, are not easy to be destroyed during feed processing, no
The nutriments such as vitamin, minerals in feed or premix can be destroyed, sour will not be caused to deteriorate feed-processing equipment
It is bad.Therefore, ethyl pyruvate can effectively substitute feeding antibiotic, answer as the feed addictive with antibacterial growth promotion
With, or be added in animal feed as the feed addictive with antibacterial growth promotion and apply, by inhibiting animal intestine
Harmful microbe breeding in road improves intestinal microecology balance, regulation enteron aisle energetic supersession and immune function etc., promotes animal raw
Long, raising feed efficiency, reduction disease incident, meet healthy aquaculture developing direction.Similarly, feeding proposed by the present invention
Material also has above-mentioned advantage.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Abuse of antibiotics will lead to bacterial pathogen and generate universal drug resistance and pharmacological property residual, and then endanger edible
The health of person.And Substitutes For Antibiotic common at present, such as probiotics, plant extracts (plants essential oil), acidulant
Deng there are many defects: microorganism formulation requires environmental condition high, and vulnerable to loss during feed processing, stability is not
By force；Plant extracts (plants essential oil) complicated component, production technology are not perfect, it is difficult to standardize and using effect is unstable；Acid
Agent specific aim is not strong, and palatability is also poor.
In consideration of it, the invention proposes a kind of ethyl pyruvates as the feed addictive with antibacterial growth promotion
Using.
It should be appreciated that within the scope of the present invention, the feed addictive for including ethyl pyruvate ingredient is this
The ethyl pyruvate proposed is invented as the application in the feed addictive with antibacterial growth promotion, can specifically include:
(1) ethyl pyruvate is separately as the feed addictive with antibacterial growth promotion；It (2) is wherein one group with ethyl pyruvate
The composition divided is as the feed addictive with antibacterial growth promotion；(3) compound product of ethyl pyruvate and carrier, or
Person is using compound product that ethyl pyruvate is the wherein composition and carrier of a component as the feeding with antibacterial growth promotion
Feed additives, wherein carrier can be cornstarch, wheat bran, defatted rice bran, Soybean Meal, calcium carbonate, silica or zeolite powder
Etc. field of fodder routine carrier.
Ethyl pyruvate is stable lipophilic pyruvate compound, molecular weight 116.12, and molecular formula is
CH3COCOOC2H5, have anti-oxidant, anti-inflammatory, antitumor, anticoagulant and adjusts cellular energy metabolism effect, and inventor's discovery removes
Outside above-mentioned effect, ethyl pyruvate also has good bacteriostasis, the especially growth to Escherichia coli and salmonella in vitro
There is obvious inhibiting effect, and noresidue after drug resistance, metabolism will not be generated, meanwhile, intestinal microecology balance and intestines can be improved
Road tissue morphology, enhancing gut integrity.Therefore, it can be used with substitute antibiotics class additive.And ethyl pyruvate is in body
Interior metabolite is pyruvic acid, and pyruvic acid is naturally present in animal body, is the intermediate product of human body energy metabolism, has
A variety of physiological activity, to humans and animals body without obvious toxic-side effects, therefore, ethyl pyruvate will not be to edible as additive
Animal and the mankind of edible animal cause damages, safety is preferable, and ethyl pyruvate also has fresh sweet flowers and fruits fragrant
Gas, palatability is good, can promote feed intake.Therefore using ethyl pyruvate as ideal feeding antibiotic substitute, there is nothing
It remains, have no drug resistance, the advantage that safety is good, palatability is good and antibacterial growth-promoting effect is good, can effectively substitute feeding
Antibiotic, by inhibit animal intestinal tract harmful microbe breeding, improve intestinal microecology balance, regulation enteron aisle energetic supersession and
Immune function etc. promotes growth of animal, improves feed efficiency, reduces disease incident, meets healthy aquaculture developing direction.
In addition, ethyl pyruvate is common compounds, it is easily obtained, catalysis oxidation can be bought or passed through by market
Ethyl lactate synthesis be voluntarily prepared, at present for, the preparation process of ethyl pyruvate is highly developed.Ethyl pyruvate
Property is stablized, and is also not easy to be destroyed in feed processing or feed addictive process, and itself does not have sour, no
The nutriments such as vitamin, minerals in feed or premix can be destroyed, acid corrosion will not be caused to damage process equipment.Cause
This, great practical value can be widely used.
Meanwhile the application that the invention also provides ethyl pyruvates in animal feed, specifically, ethyl pyruvate can
To be added in animal feed as the feed addictive with antibacterial growth promotion.It should be appreciated that this is to pyruvic acid second
The application mode of antibacterial growth promotion effect of ester is added in animal feed and by mixed feedstuff feeding to raising
Animal edible, so that it is somatotrophic to play the role of antibacterial.Its addition manner includes but is not limited to following approach:
The ethyl pyruvate is added to livestock and poultry or aquatic products directly as the feed addictive with antibacterial growth promotion
In animal feed.Ethyl pyruvate is added directly into basal feed, is mixed, is fed dynamic to corresponding livestock and poultry or aquatic products
Object.(2) premix that the ethyl pyruvate and feed addictive or feedstuff are mixed is added to livestock and poultry or aquatic products
In animal feed；Alternatively, the concentrate feed that the ethyl pyruvate is mixed with feed addictive or feedstuff is added to
In livestock and poultry or aquatic animal feed.Above-mentioned feed addictive can be the field of fodder such as nutritive additive, flavoring agent, pest repellant
In conventional feed addictive any one or it is a variety of, above-mentioned feedstuff can be grain raw grain, soybean, dregs of beans, jade
Rice, cereal etc. are for processing and fabricating feed but are not belonging to any one or more in the feeding substance of feed addictive.In this way, can
Further to enrich the nutrition and effect of feed.(3) pre-mixing agent that ethyl pyruvate and carrier are mixed is added to livestock and poultry
Or in aquatic animal feed.Carrier can be cornstarch, wheat bran, defatted rice bran, Soybean Meal, calcium carbonate, silica or boiling
The carrier of the field of fodder such as mountain flour routine, in this way, ethyl pyruvate can be carried and protect the physical property of ethyl pyruvate not
It shows again, to avoid its denaturation.(4) after the ethyl pyruvate and carrier being mixed and made into pre-mixing agent, then by institute
Premix made of pre-mixing agent is stated to be added in livestock and poultry or aquatic animal feed；Alternatively, the ethyl pyruvate is mixed with carrier
After pre-mixing agent is made in conjunction, then concentrate feed made of the pre-mixing agent is added in livestock and poultry or aquatic animal feed.
Wherein, the additive amount of above-mentioned ethyl pyruvate is the 0.002~0.5% of animal feed gross mass.
Although ethyl pyruvate has antibacterial growth promoting function, it is ensured that raising animal health promotes its growth, and third
The usage amount of keto acid ethyl ester is but not The more the better, can endanger raising animal when usage amount is excessively high instead.Therefore, in the present embodiment
In, the ethyl pyruvate in actual use, 0.002 that animal feed gross mass is accounted for the additive amount of the ethyl pyruvate
Subject to~0.5%, in this dosage range, the edible animal feed added with ethyl pyruvate can inhibit animal intestinal tract harmful
The breeding of microorganism promotes growth of animal, improves feed efficiency, reduces disease.
It should be noted that above-mentioned livestock and poultry or aquatic livestock include but is not limited to weanling pig, broiler chicken, laying hen or crucian etc.
Deng, meanwhile, the difference of the animal species fed when according to practical application, livestock and poultry or aquatic animal feed be not also identical, at this
In one embodiment, animal feed is preferably pannage, ox feed, sheep feed, chicken feed, duck feed, horse feeding for invention
Material, rabbit feed or fish meal.
In addition, the feed includes ethyl pyruvate the invention also provides a kind of feed.
Wherein, ethyl pyruvate accounts for the 0.002~0.5% of the feed relative；The animal feed is pannage, ox feeding
Material, sheep feed, chicken feed, duck feed, horse feed, rabbit feed or fish meal.
Currently, saving the time of user's voluntarily formula feed, it will usually which various additives are pre- with feed for convenience of using
It first mixes, is prepared into premixed feed.Ethyl pyruvate can be equally pre-mixed with feed, be prepared into premixed feed, all
Premixed feed comprising above-mentioned ethyl pyruvate is within the scope of the invention.
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
It should be noted that in following each table, colleague shoulder mark difference lowercase (a, b, c) expression significant difference (P <
0.05)。
Application Example 1
Using inhibition zone method measurement ethyl pyruvate to the bacteriostatic activity of Escherichia coli and salmonella, cortex cinnamomi is concurrently set
Oily control group and origanum oil control group, and it is as shown in table 1 below to record each detection group antibacterial circle diameter.
The comparison of 1 fungistatic effect of table
By the result in table 1 it is found that the life of cinnamon oil, origanum oil and ethyl pyruvate to Escherichia coli and salmonella
With obvious inhibiting effect, meanwhile, compared with cinnamon oil control group and origanum oil control group, ethyl pyruvate control group it is antibacterial
Circle is bigger, illustrates that ethyl pyruvate is significantly better than cinnamon oil and origanum oil to the inhibitory effect of Escherichia coli and salmonella,
That is selecting ethyl pyruvate more excellent as the fungistatic effect of the feed addictive with antibacterial growth promotion.
Application Example 2
300 weight close (6.34 ± 0.49kg) and the consistent weanling pig of gender (21 ± 1 age in days) are randomly divided into 6
Group: including IV group of blank control group, positive control group, test I group, test II group, test III group and test, 5 repetitions of every component
(column), 10, every column.Wherein, prepared by the pig starter feed according to the form below 2 of each group feeding.After raising 28 days, measurement weanling pig growth
Performance, intestinal tissue form, enteron aisle chyme pH and faecal flora quantity, as a result such as the following table 3 to 5.
2 pig starter feed of table matches table
Wherein, colistin sulfate is basic polypeptide class antibiotic, to Gram-negative bacteria (especially Escherichia coli, Salmonella
Bacterium, Pseudomonas aeruginosa, proteus and haemophilus etc.) have high inhibition effect, to gram-positive bacteria (except Staphylococcus aureus and
Outside hemolytic streptococcus) and fungi without effect, be mainly used for preventing and treating the infection of sensitive bacteria and promote growth of animals or poultry, and it is a kind of often
With antibiotics feed addictive.The present embodiment selects the commercially available colistin sulfate by the good animal pharmaceutical estate production in Jiangxi day.
The growth performance of weanling pig during being tested in 3 Application Example 2 of table
From upper table 3 it is found that compared with blank control group, positive control group, test I group, test II group, test III group and examination
IV group of average daily gain to be tested to obviously increase, feed-weight ratio and diarrhea rate significantly reduce, meanwhile, compared with positive control group, test I
Group, test II group, test III group and the average daily gain increasing degree of IV group of test, feed-weight ratio and diarrhea rate reduction amplitude are more
Greatly, illustrate that ethyl pyruvate can promote piglet to grow, and reduce its diarrhea rate, and significant effect.In addition, feeding is added to third
The average daily gain of the piglet of the feed of keto acid ethyl ester is also apparently higher than positive control group and blank control group, illustrates pyruvic acid second
Ester can promote piglet to search for food, that is, palatability is more preferably.
Wean intestine of young pigs tissue morphology in 4 Application Example 2 of table
From upper table 4 it is found that compared with blank control group, positive control group, test I group, test II group, test III group and examination
Testing IV group of enteron aisle height of naps increased, but enteron aisle Crypt depth decreases, meanwhile, compared with positive control group, test I
Group, test II group, test III group and IV group of intestine of young pigs height of naps increase rate of test are bigger, and Crypt depth reduces brighter
It is clear, illustrate that ethyl pyruvate can improve weanling pig intestinal tissue form, enhancing gut integrity, and significant effect.
Wean intestine of young pigs Chyme pH and faecal flora quantity in 5 Application Example 2 of table
From upper table 5 it is found that compared with blank control group, positive control group, test I group, test II group, test III group and examination
The pH value and colon Escherichia coli for testing IV group of enteron aisle chyme significantly reduce, meanwhile, feeding is added to ethyl pyruvate feed
Piglet colon lactic acid bacteria increased significantly, illustrate that ethyl pyruvate can reduce the pH value of enteron aisle chyme, inhibit colon large intestine bar
Bacterium breeding, promotes lactobacter growth, improves hindgut micro-ecological environment, reduces intestines problem, and significant effect.
In conclusion ethyl pyruvate can promote piglet to grow, the quantity of enteron aisle Escherichia coli is reduced, reduces enteron aisle disease
Disease occurs, and has the function of substitute antibiotics.
Application Example 3
The section's treasured Broiler chicks (half male and half female) for choosing 180 1 age in days health, are randomly divided into 3 groups by principle similar in weight:
Blank control group, positive control group and test group, 6 repetitions (cage) of every component, 10, every cage.The base of test group and control group fed
Plinth daily ration is consistent, the difference is that:
The feed producing method of blank control group: corn bean pulp type basal diet；
The feed producing method of positive control group: into corn bean pulp type daily ration, addition accounts for the yellow mould of total feed quality 4mg/kg
Element；
The feed producing method of test group: ethyl pyruvate and defatted rice bran are sufficiently mixed according to the mass ratio of 1:1, system
At pre-mixing agent, then pre-mixing agent is added in corn bean pulp type daily ration in 1.0% ratio and (contains ethyl pyruvate in practical feed
0.5%).
After feeding 42 days, the quantity of microorganism in meat chicken growth performance and caecum, statistical result such as the following table 6 institute are counted
Show.
Wherein, flavomycoin is phosphorylated polysaccharide class antibiotic, and Antibacterial mechanism is the structure by interfering cell wall
The biosynthesis of substance peptide glycan is to inhibit the breeding of bacterium.It is equally a kind of common antibiotics feed addictive.
In 6 Application Example 3 of table in the growth performance and caecum of broiler chicken microorganism quantity
From upper table 6 it is found that compared with blank control group, the average feed intake and average weight gain of positive control group and test group are equal
Increase, feed-weight ratio is declined, but test group significantly improve broiler chicken average weight gain and reduce feed-weight ratio.In addition,
Compared with blank control group, Escherichia coli and lactic acid bacterium number in positive control group broiler chicken caecum are significantly lowered, and test group
Escherichia coli quantity reduces in broiler chicken caecum but lactic acid bacterium number significantly improves.Therefore, ethyl pyruvate can promote broiler chicken
It grows and application effect is good, enteron aisle Escherichia coli can be inhibited to breed, promote lactobacter growth, improve intestine microenvironment
Significant effect has the function of substitute antibiotics.
Application Example 4
(1) ethyl pyruvate and silica are sufficiently mixed according to the mass ratio of 1:1, are prepared into antibacterial growth promotion
The feed addictive of effect.
(2) 300 tail of hybridized prussian carp that weight is 6.20 ± 0.05g is chosen, 2 groups, including control group and test are randomly divided into
Group, 5 repetitions (case) of every component, every 30 tail of case.The basal diet of each group feeding is consistent, the difference is that, the feeding of test group
In material added with account for total feed quality 0.2% feed addictive (step (1) be made, contain ethyl pyruvate in practical feed
0.1%) flavomycoin of 2mg/kg, is added in the feed of control group.By 8 weeks growth tests, the life of hybridized prussian carp is counted
Long performance and enteron aisle Escherichia coli quantity, statistical result are as shown in table 7 below.
The growth performance and enteron aisle coliform count of hybridized prussian carp in 7 Application Example 4 of table
| Project | Control group | Test group |
| Body weight increase rate (%) | 80.8±4.45b | 92.4±5.81a |
| Specific growth rate (%) | 1.11±0.07b | 1.27±0.04a |
| Feed coefficient (%) | 2.44±0.16a | 2.07±0.10b |
| Coliform count | 1.00±0.09a | 0.70±0.07b |
By the result in table 7 it is found that compared with the control group, the body weight increase rate and particular growth of the hybridized prussian carp of test group
Rate obviously increases, and Escherichia coli quantity is substantially reduced in feed coefficient and enteron aisle, illustrates to educate silver using ethyl pyruvate feeding is different
Crucian carp can promote allogynogenetic crucian carp, reduce the quantity of enteron aisle Escherichia coli, have the function of substitute antibiotics.
The above is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.
Claims (10)
1. a kind of application of ethyl pyruvate as the feed addictive with antibacterial growth promotion.
2. a kind of application of ethyl pyruvate in animal feed, which is characterized in that as the feeding with antibacterial growth promotion
Feed additives are added in animal feed.
3. application of the ethyl pyruvate as claimed in claim 2 in animal feed, which is characterized in that the animal feed is
Pannage, ox feed, sheep feed, chicken feed, duck feed, horse feed, rabbit feed or fish meal.
4. application of the ethyl pyruvate as claimed in claim 2 in animal feed, which is characterized in that the ethyl pyruvate
It is added in livestock and poultry or aquatic animal feed directly as the feed addictive with antibacterial growth promotion.
5. application of the ethyl pyruvate as claimed in claim 2 in animal feed, which is characterized in that by the pyruvic acid second
The premix that ester and feed addictive or feedstuff are mixed is added in livestock and poultry or aquatic animal feed；And/or
The concentrate feed that the ethyl pyruvate is mixed with feed addictive or feedstuff is added to livestock and poultry or aquatic products moves
In object feed.
6. application of the ethyl pyruvate as claimed in claim 2 in animal feed, which is characterized in that by the pyruvic acid second
The pre-mixing agent that ester and carrier are mixed is added in livestock and poultry or aquatic animal feed.
7. application of the ethyl pyruvate as claimed in claim 2 in animal feed, which is characterized in that by the pyruvic acid second
After ester and carrier are mixed and made into pre-mixing agent, premix made of the pre-mixing agent is then added to livestock and poultry or aquatic animal feed
In；And/or
After the ethyl pyruvate and carrier are mixed and made into pre-mixing agent, then concentrate feed made of the pre-mixing agent is added to
In livestock and poultry or aquatic animal feed.
8. such as application of the described in any item ethyl pyruvates of claim 2 to 7 in animal feed, which is characterized in that described
The additive amount of ethyl pyruvate is the 0.002~0.5% of animal feed total weight.
9. a kind of feed, which is characterized in that including ethyl pyruvate.
10. feed as claimed in claim 9, which is characterized in that the ethyl pyruvate account for the feed relative 0.002~
0.5%；And/or
The animal feed is pannage, ox feed, sheep feed, chicken feed, duck feed, horse feed, rabbit feed or fish meal.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524119A (en) * | 2009-04-16 | 2009-09-09 | 浙江工业大学 | Lean-type feed additive and application thereof |
| KR20170047458A (en) * | 2015-10-22 | 2017-05-08 | 경희대학교 산학협력단 | A pharmaceutical composition for preventing or treating peripheral neurodegenerative diseases comprising ethyl pyruvate |
-
2019
- 2019-01-28 CN CN201910082949.3A patent/CN109588559A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524119A (en) * | 2009-04-16 | 2009-09-09 | 浙江工业大学 | Lean-type feed additive and application thereof |
| KR20170047458A (en) * | 2015-10-22 | 2017-05-08 | 경희대학교 산학협력단 | A pharmaceutical composition for preventing or treating peripheral neurodegenerative diseases comprising ethyl pyruvate |
Non-Patent Citations (2)
| Title |
|---|
| TEWODROS DEBEBE ET.AL.: "Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms", 《PLOS ONE》 * |
| 陈宁 等: "《高等学校专业教材 酶工程》", 31 August 2005, 中国轻工业出版社 * |
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