CN109568668A - Polypropylene/poly-dopamine composite patch preparation method and composite patch and application - Google Patents
Polypropylene/poly-dopamine composite patch preparation method and composite patch and application Download PDFInfo
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- CN109568668A CN109568668A CN201811447336.7A CN201811447336A CN109568668A CN 109568668 A CN109568668 A CN 109568668A CN 201811447336 A CN201811447336 A CN 201811447336A CN 109568668 A CN109568668 A CN 109568668A
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- polypropylene
- poly
- dopamine
- composite patch
- solution
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- 239000004743 Polypropylene Substances 0.000 title claims abstract description 130
- 229920001690 polydopamine Polymers 0.000 title claims abstract description 100
- 239000002131 composite material Substances 0.000 title claims abstract description 73
- 229920000333 poly(propyleneimine) Polymers 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- -1 polypropylene Polymers 0.000 claims abstract description 73
- 229920001155 polypropylene Polymers 0.000 claims abstract description 65
- 239000000243 solution Substances 0.000 claims abstract description 48
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 23
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002356 single layer Substances 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims abstract description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 37
- 239000000463 material Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000011734 sodium Substances 0.000 claims description 21
- 229910052708 sodium Inorganic materials 0.000 claims description 21
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 claims description 19
- 239000007864 aqueous solution Substances 0.000 claims description 19
- 239000012153 distilled water Substances 0.000 claims description 19
- 229960001149 dopamine hydrochloride Drugs 0.000 claims description 19
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- 238000011010 flushing procedure Methods 0.000 claims description 14
- 235000002639 sodium chloride Nutrition 0.000 claims description 13
- 229920006395 saturated elastomer Polymers 0.000 claims description 10
- 239000007983 Tris buffer Substances 0.000 claims description 8
- 239000012266 salt solution Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 5
- 239000012047 saturated solution Substances 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- ZUUQXSPPZGGMGU-UHFFFAOYSA-K potassium disodium dihydrogen phosphate chloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])O.[Na+].[Na+].[Cl-] ZUUQXSPPZGGMGU-UHFFFAOYSA-K 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 238000007912 intraperitoneal administration Methods 0.000 abstract description 10
- 210000000056 organ Anatomy 0.000 abstract description 4
- 210000001015 abdomen Anatomy 0.000 abstract description 3
- 238000006073 displacement reaction Methods 0.000 abstract description 3
- 239000011780 sodium chloride Substances 0.000 description 7
- 229960002668 sodium chloride Drugs 0.000 description 7
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000021970 Abdominal wall defect Diseases 0.000 description 4
- 150000001336 alkenes Chemical class 0.000 description 4
- 229960003638 dopamine Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 206010019909 Hernia Diseases 0.000 description 2
- 208000008081 Intestinal Fistula Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 238000009954 braiding Methods 0.000 description 2
- 239000013626 chemical specie Substances 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 206010060954 Abdominal Hernia Diseases 0.000 description 1
- UJICRSDQYCVRRM-UHFFFAOYSA-M CCCCC(CC)COP(O)(OCC(CC)CCCC)=O.[Na+].[Cl-] Chemical compound CCCCC(CC)COP(O)(OCC(CC)CCCC)=O.[Na+].[Cl-] UJICRSDQYCVRRM-UHFFFAOYSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses polypropylene/poly-dopamine composite patch preparation method and composite patch and applications.Preparation method of the present invention can quickly be split away off poly-dopamine film using sodium hypochlorite from polypropylene and propene polymer patch density is less than the principle of saturated brine solution, single layer composite patch is divided into two sides from nanoscale, it is polypropylene/poly-dopamine film surface on one side, it effectively prevent composite patch and intraperitoneal organ adhesion, another side is the polypropylene face of exposure after poly-dopamine nanometer film falls off, it is contacted in the face and peritonaeum, increase abdomen wall tension, the risk of displacement can be reduced, structure is more reasonable, can meet requirement in peritonaeum and intraperitoneal simultaneously.The preparation method is not related to a variety of composite materials and stacks compound simultaneously, and gained polypropylene/poly-dopamine composite patch thickness keeps sticking patch more frivolous from the thickness for macroscopically maintaining pure PP sticking patch, has great clinical value.
Description
Technical field
The present invention relates to medical material and its preparation technical fields, in particular it relates to which polypropylene/poly-dopamine is multiple
Close sticking patch and the preparation method and application thereof.
Background technique
From patching material applied to after herniorrhaphy, the recurrence rate of abdominal hernia is decreased obviously, and postoperative chronic ache occurs
Rate also reduces.The requirement of dual character should be met for the sticking patch of intraperitoneal repairing, had on one side tight in adhesiving effect, with peritonaeum
Closely connected conjunction reduces displacement risk；In addition there is preventing adhesiving effect on one side, with intraperitoneal organ adhesion, reduce intestines stalk
The risks such as resistance and intestinal fistula.However currently, the intraperitoneal sticking patch majority dependence import clinically applied, expensive, production work
Skill is complicated, and two-sided sticking patch is nearly all sandwich structure, causes sticking patch thickness to increase, may bring discomfort.
Majority adherence preventing material is researched and developed based on polypropylene (polypropylene, PP) at present.Propene polymer patch be by
Polypropylene fibre braiding made of, the sticking patch with single layer reticular structure, be most common abdominal-wall defect patching material.Its
With light weight, foreign body sensation is light, tensile strength is high, chemical species corrode, promotion body fibroblast grows into and granulation group
It knits the advantages that having integrated, therefore the risk of sticking patch infection, displacement can be reduced, there is irreplaceable advantage.But simple
PP mesh sheet patch faces are coarse, and there are the risks such as internal organs adhesion, intestinal obstruction and intestinal fistula when for intraperitoneal repairing, secondly, into
The big abdominal-wall defect repairing of row, the scar contraction in later period will cause mesh sheet distortion, and may stimulate and damage surrounding tissue, cause
Infection and skin tunnel.
For the drawbacks described above for overcoming simple PP mesh sheet, researcher utilizes the adhesion of dopamine, by dopamine oxidation polymerization
It is coated on polypropylene mesh surface while forming poly-dopamine, forms polypropylene/poly-dopamine composite patch, experimental result is aobvious
Show that it, with excellent preventing adhesiving effect, can safely be placed in cavum peritoneale.But gained composite patch two sides is all by poly- more
Bar amine coating, i.e., resulting composite patch two sides all have the characteristic to prevent adhesion, there is the risk easily shifted, clinically there are still
Some problems.Therefore, be badly in need of seek it is a kind of facilitate on one side adhesion peritonaeum, another side have preventing adhesiving effect single-layer double-side knot
The polypropylene composite materials sticking patch of structure.
Summary of the invention
Based on this, the invention reside in overcoming the deficiencies of existing technologies, a kind of polypropylene/poly-dopamine composite patch is provided
A kind of compound benefit of polypropylene/poly-dopamine of single-layer double-side structure has been prepared using the preparation method for preparation method
Piece, so that polypropylene/poly-dopamine composite patch two sides has different characteristics, structure is more reasonable, meets in peritonaeum respectively
It with intraperitoneal requirement, while keeping sticking patch thickness almost unchanged, is a kind of completely new medical abdominal external hernia repair materials, and the system
Make simple process and low cost, stable operation.
Another object of the present invention is to provide a kind of polypropylene for abdominal-wall defect/poly-dopamine composite patch, institutes
State polypropylene/poly-dopamine composite patch prevent adhesion, be frivolous with single side, good biocompatibility and cheap etc. excellent
Point.
Another object of the present invention is to provide the applications of the polypropylene/poly-dopamine composite patch.
Its technical solution is as follows:
A kind of preparation method of polypropylene/poly-dopamine composite patch, includes the following steps:
Step S1: configuration 5-20mmol/L tris solution is then added Dopamine hydrochloride, is configured to salt
Sour dopamine solubility is 0.5-2.8g/L, and polypropylene mesh is added into above-mentioned solution, is stirred under 10-40 DEG C of air atmosphere anti-
It takes out, rinses and dries after answering 10-72h, obtain the compound mesh material of polypropylene/poly-dopamine；
Step S2: sodium hypochlorite is then added into saturated salt solution for the saturated brine solution that configuration density is greater than water,
It is configured to sodium hypochlorite-saturated brine solution that volumetric concentration is 0.1%-99%；Or salt is added in sodium hypochlorite and makes
Salt reaches saturation state in sodium hypochlorite, and dose volume concentration is 100% sodium hypochlorite-saturated salt solution；
Step S3: the compound mesh material of polypropylene/poly-dopamine is placed on above-mentioned sodium hypochlorite-saturated brine solution or secondary
Compound mesh sheet is taken out in sodium chlorate-saturated salt solution, after 30s-30min, it is dry with distilled water flushing 2-5 times, it is double to obtain single layer
The polypropylene of face structure/poly-dopamine composite patch.
Sodium hypochlorite-saturated brine solution or sodium hypochlorite-saturated salt solution density are greater than water in the present invention, and poly- third
Alkene density is about 0.92g/cm3, be less than water, sodium hypochlorite can quickly fall off poly-dopamine nanometer film, therefore, by polypropylene/
The compound mesh material of poly-dopamine is gently placed on certain density sodium hypochlorite saturated brine solution or sodium hypochlorite-saturated salt is molten
In liquid, polypropylene/poly-dopamine composite web sector-meeting is swum on the water surface, and preparation method of the present invention utilizes propene polymer patch
Density is less than the principle that saturated brine solution and sodium hypochlorite can quickly fall off poly-dopamine, answers single layer from nanoscale
It closes sticking patch and is divided into two sides, be polypropylene/poly-dopamine nanometer film on one side, composite patch and intraperitoneal device can be effectively prevent
Official's adhesion, another side are polypropylene, are to handle polypropylene/poly-dopamine composite web sheet material with certain density sodium hypochlorite
Material, makes the poly-dopamine film in the face fall off to form virgin pp face, contacts in the face and peritonaeum, can increase abdomen wall tension, subtract
The risk shifted less.Meanwhile preparation method of the present invention is not related to a variety of composite materials and stacks compound, gained composite patch
Thickness keeps the thickness of pure PP sticking patch substantially, keeps sticking patch more frivolous.Therefore, polypropylene made from the method/poly- more is utilized
Bar amine composite patch two sides has different characteristics, and structure is more reasonable, meets requirement in peritonaeum and intraperitoneal respectively, simultaneously
It keeps sticking patch thickness almost unchanged, is a kind of completely new medical abdominal external hernia repair materials.Pass through regulation preparation work in experimentation
Skill condition, such as: Dopamine hydrochloride solubility, sodium hypochlorite concentration, reaction time, it can be in Effective Regulation composite patch poly- third
Alkene and polypropylene/poly-dopamine thickness proportion.
The step S2 in one of the embodiments, are as follows: configuration saturated brine solution, then, toward saturated brine solution
Middle addition sodium hypochlorite is configured to sodium hypochlorite-saturated brine solution that volumetric concentration is 1%-10%.
The saturated brine solution is the saturation for being saturated sodium-salt aqueous solution or sodium salt and sylvite in one of the embodiments,
Solution.
The saturated brine solution is saturated sodium-chloride water solution or sodium chloride-di(2-ethylhexyl)phosphate in one of the embodiments,
Hydrogen potassium-sodium dihydrogen phosphate mixing saturated solution.
The Dopamine hydrochloride solubility prepared in the step S1 in one of the embodiments, is 2.4-2.8g/L.It is preferred that
, the Dopamine hydrochloride solubility prepared in the step S1 is 2.4g/L.
The time that the step S1 is stirred to react in one of the embodiments, is 24-48h.
The size of polypropylene mesh is (2-3) cm × (2-3) cm in the step S1 in one of the embodiments,.
In one of the embodiments, in step S3 the compound mesh material of polypropylene/poly-dopamine in sodium hypochlorite-saturation
Standing time in saline solution is 1min-10min.
The polypropylene that the preparation method obtains/poly-dopamine composite patch, including polypropylene face and polypropylene/poly- more
Bar amine film surface.
Polypropylene of the present invention/poly-dopamine composite patch is polypropylene material on one side, helps to be adhered to peritonaeum
It is interior, another side be polypropylene/poly-dopamine film surface, have preventing adhesiving effect, it is possible to reduce with intra-abdominal organ adhesion, thus have
Have the advantages that single side prevent adhesion, be frivolous, good biocompatibility and cheap.
The polypropylene/application of the poly-dopamine composite patch in herniorrhaphy.Polypropylene of the present invention/poly-
Dopamine composite patch can be used in the herniorrhaphy of abdominal-wall defect, have great clinical value.
The invention also discloses the polypropylene/application of the poly-dopamine composite patch in herniorrhaphy.
The beneficial effects of the present invention are:
(1) polypropylene of the present invention/poly-dopamine composite patch has the characteristic of single-layer double-side, is poly- third on one side
Alkene/poly-dopamine nanometer film is compound, and poly-dopamine property is stablized, and has good hydrophily and biocompatibility, effectively prevent
Composite patch and intraperitoneal organ adhesion, another side are polypropylene, and polypropylene has good tensile strength, chemical species
Aggressivity, foreign body sensation is light, and body fibroblast can be promoted to grow into, and contacts in the face and peritonaeum, increases abdomen wall tension, can subtract
The risk shifted less；
(2) polypropylene of the present invention/poly-dopamine composite patch, it is compound to be not that a variety of composite materials stack, and
It is single-layer double-side structure, macroscopically keeps the thickness of commercial polypropylene sticking patch, it is whole more frivolous, while maintaining certain net
Pore structure is grown into, the free entry and exit of macrophage and leucocyte conducive to tissue, have preferable tissue intensity, pull resistance and
Anti-infection property；
(3) polypropylene of the present invention/poly-dopamine composite patch manufacture craft is simple, at low cost, stable operation.
Detailed description of the invention
Fig. 1 is polypropylene/poly-dopamine composite patch polypropylene/poly-dopamine film surface SEM figure in embodiment 1.
Fig. 2 is the SEM figure in polypropylene/poly-dopamine composite patch polypropylene face in embodiment 1.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, below in conjunction with attached drawing and specific embodiment party
Formula, the present invention is further described in detail.It should be understood that the specific embodiments described herein are only to solve
The present invention is released, and the scope of protection of the present invention is not limited.
Polypropylene mesh used in following embodiment is medical light weight sticking patch made of polyacrylic fibres braiding, and mesh diameter is
2mm。
Embodiment 1
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 10mmol/L tris solution 50mL is then added 0.12g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.4g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is stirred to react under air atmosphere and takes out afterwards for 24 hours, with distilled water flushing and drying, obtain polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in distilled water, is continuously added until being configured to saturated common salt aqueous solution, then, root
According to the volume of saturated common salt aqueous solution, sodium hypochlorite is added into above-mentioned solution, is made into the sodium hypochlorite-that volumetric concentration is 1%
Saturated common salt aqueous solution；
Step S3: the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium hypochlorite-
Compound mesh sheet is taken out in saturated common salt aqueous solution, after 10min, it is dry with distilled water flushing 2-5 times, obtain single-layer double-side structure
Polypropylene/poly-dopamine composite patch.
Embodiment 2
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 10mmol/L tris solution 50mL is then added 0.12g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.4g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is stirred to react under air atmosphere and takes out afterwards for 24 hours, with distilled water flushing and drying, obtain polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in distilled water, is continuously added until being configured to saturated common salt aqueous solution, then, root
According to the volume of saturated common salt aqueous solution, sodium hypochlorite is added into above-mentioned solution, is made into the sodium hypochlorite that volumetric concentration is 10%
Saturated common salt aqueous solution；
Step S3: the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium hypochlorite-
Compound mesh sheet is taken out in saturated common salt aqueous solution, after 1min, it is dry with distilled water flushing 2-5 times, obtain single-layer double-side structure
Polypropylene/poly-dopamine composite patch.
Embodiment 3
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 10mmol/L tris solution 50mL is then added 0.12g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.4g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is stirred to react under air atmosphere and takes out afterwards for 24 hours, with distilled water flushing and drying, obtain polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in distilled water, is continuously added until being configured to saturated common salt aqueous solution, then, root
According to the volume of saturated common salt aqueous solution, sodium hypochlorite is added into above-mentioned solution, is made into the sodium hypochlorite-that volumetric concentration is 5%
Saturated common salt aqueous solution；
Step S3: the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium hypochlorite-
Compound mesh sheet is taken out in saturated common salt aqueous solution, after 5min, it is dry with distilled water flushing 2-5 times, obtain single-layer double-side structure
Polypropylene/poly-dopamine composite patch.
Embodiment 4
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 10mmol/L tris solution 50mL is then added 0.12g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.4g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is stirred to react under air atmosphere and takes out afterwards for 24 hours, with distilled water flushing and drying, obtain polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in distilled water, is continuously added up to being configured to saturated common salt aqueous solution, then, past
Excessive potassium dihydrogen phosphate (until excessively referring to that being added to potassium dihydrogen phosphate no longer dissolves) is added in above-mentioned solution, adds excessive
Sodium dihydrogen phosphate (until excessively referring to that sodium dihydrogen phosphate no longer dissolves), it is full further according to sodium chloride-potassium dihydrogen phosphate-sodium dihydrogen phosphate
With the volume of solution, sodium hypochlorite is added into above-mentioned solution, is made into sodium hypochlorite-sodium chloride-phosphoric acid that volumetric concentration is 5%
Potassium dihydrogen-sodium dihydrogen phosphate saturated solution；
Step S3: the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium hypochlorite-
Sodium chloride-potassium dihydrogen phosphate-sodium dihydrogen phosphate saturated solution takes out compound mesh sheet after 5min, with distilled water flushing 2-5 times, does
It is dry, obtain polypropylene/poly-dopamine composite patch of single-layer double-side structure.
Embodiment 5
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 20mmol/L tris solution 50mL is then added 0.14g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.8g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is stirred to react under air atmosphere and takes out afterwards for 24 hours, with distilled water flushing and drying, obtain polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in sodium hypochlorite and sodium chloride is made to reach saturation state in sodium hypochlorite, prepares
100% sodium hypochlorite of concentration-saturated common salt solution；
Step S3: it is full that the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium chlorate-
Compound mesh sheet is taken out in salt solution, after 30s, it is dry with distilled water flushing 2-5 times, obtain poly- the third of single-layer double-side structure
Alkene/poly-dopamine composite patch.
Embodiment 6
A kind of polypropylene/poly-dopamine composite patch is single-layer double-side structure, is on one side polypropylene wire side, another side
For polypropylene/poly-dopamine film surface, i.e. another side is the poly-dopamine film for being coated on polypropylene mesh surface, and preparation process is such as
Under:
Step S1: configuration 5mmol/L tris solution 50mL is then added 0.025g Dopamine hydrochloride,
Preparation Dopamine hydrochloride solubility is 2.4g/L, the polypropylene mesh of 1 2.5cm × 2.5cm is added into above-mentioned solution, at 28 DEG C
It is taken out after being stirred to react 48h under air atmosphere, with distilled water flushing and drying, obtains polypropylene/poly-dopamine composite web sheet material
Material；
Step S2: sodium chloride is added in distilled water, is continuously added until being configured to saturated common salt aqueous solution, then, root
According to the volume of saturated common salt aqueous solution, sodium hypochlorite is added into above-mentioned solution, is made into the hypochlorous acid that volumetric concentration is 0.5%
Sodium-saturated common salt aqueous solution；
Step S3: the resulting compound mesh material of polypropylene/poly-dopamine of step S1 is gently placed on above-mentioned sodium hypochlorite-
Compound mesh sheet is taken out in saturated common salt aqueous solution, after 30min, it is dry with distilled water flushing 2-5 times, obtain single-layer double-side structure
Polypropylene/poly-dopamine composite patch.
SEM test is carried out to polypropylene prepared by embodiment 1-6/poly-dopamine composite patch, observes scanning electron microscope (SEM) photograph
It was found that polypropylene/poly-dopamine composite patch be one side be it is smooth, on one side have particulate material.Fig. 1 is in embodiment 1
Polypropylene/poly-dopamine composite patch polypropylene/poly-dopamine film surface SEM figure, from the figure, it can be seen that largely poly- more
Bar amine nano particle is carried on PP sticking patch, and Fig. 2 is polypropylene/poly-dopamine composite patch polypropylene face in embodiment 1
SEM figure, the face is smooth as can be seen from Fig., and poly-dopamine falls off.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of polypropylene/poly-dopamine composite patch preparation method, which comprises the steps of:
Step S1: configuration 5-20mmol/L tris solution is then added Dopamine hydrochloride, it is more to prepare hydrochloric acid
Bar amine solubility is 0.5-2.8g/L, and polypropylene mesh is added into above-mentioned solution, is stirred to react under 10-40 DEG C of air atmosphere
It takes out, rinses and dries after 10-72h, obtain the compound mesh material of polypropylene/poly-dopamine；
Step S2: sodium hypochlorite is then added into saturated salt solution for the saturated brine solution that configuration density is greater than water, prepares
Sodium hypochlorite-the saturated brine solution for being 0.1%-99% at volumetric concentration；Or salt is added in sodium hypochlorite and salt is made to exist
Reach saturation state in sodium hypochlorite, dose volume concentration is 100% sodium hypochlorite-saturated salt solution；
Step S3: the compound mesh material of polypropylene/poly-dopamine is placed on above-mentioned sodium hypochlorite-saturated brine solution or hypochlorous acid
Compound mesh sheet is taken out in sodium-saturated salt solution, after 30s-30min, it is dry with distilled water flushing 2-5 times, obtain single-layer double-side knot
The polypropylene of structure/poly-dopamine composite patch.
2. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that the step
Rapid S2 are as follows: sodium hypochlorite is then added into saturated brine solution for configuration saturated brine solution, and being configured to volumetric concentration is
Sodium hypochlorite-saturated brine solution of 1%-10%.
3. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that described full
It is the saturated solution for being saturated sodium-salt aqueous solution or sodium salt and sylvite with saline solution.
4. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that described full
It is saturated sodium-chloride water solution or sodium chloride-potassium dihydrogen phosphate-sodium dihydrogen phosphate mixing saturated solution with saline solution.
5. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that the step
The Dopamine hydrochloride solubility prepared in rapid S1 is 2.4-2.8g/L.
6. polypropylene according to claim 5/poly-dopamine composite patch preparation method, which is characterized in that the step
The Dopamine hydrochloride solubility prepared in rapid S1 is 2.4g/L.
7. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that the step
The time that rapid S1 is stirred to react is 24-48h.
8. polypropylene according to claim 1/poly-dopamine composite patch preparation method, which is characterized in that step S3
Standing time of the middle compound mesh material of polypropylene/poly-dopamine in sodium hypochlorite-saturated brine solution is 1min-10min.
9. the polypropylene that preparation method described in claim 1-8 any claim obtains/poly-dopamine composite patch, special
Sign is, including polypropylene face and polypropylene/poly-dopamine film surface.
10. polypropylene as claimed in claim 9/application of the poly-dopamine composite patch in herniorrhaphy.
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| SU1683885A1 (en) * | 1988-04-07 | 1991-10-15 | Предприятие П/Я В-8147 | Method of manufacturing products from double-layer sheet material |
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| US20050058688A1 (en) * | 2003-02-22 | 2005-03-17 | Lars Boerger | Device for the treatment and prevention of disease, and methods related thereto |
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