CN109549778B - 一种天然多糖基医用抗菌水胶体敷料及其制备方法 - Google Patents
一种天然多糖基医用抗菌水胶体敷料及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种天然多糖基医用抗菌水胶体敷料,由背衬支撑层、水胶体层和剥离层构成,所述水胶体层由热塑性弹性体、天然多糖及交联剂组成。水胶体敷料具有良好的舒适性以及皮肤粘合强度,可伸展性为1.5N/cm~3N/cm,永久变形≤1%,贴近正常皮肤的伸展性,能够提供良好的舒适性;剥离强度为4N/cm~5N/cm,水胶体吸液倍率≥18倍,保水时间≥48小时,水蒸气透过率>20g·m‑2·24h‑1,对常见金黄色葡萄球菌及大肠杆菌具有良好的抗菌作用,同时生物相容性高,能够有效预防伤口的感染,同时也可以用于感染的创面。
Description
技术领域
本发明属于医疗用品领域,涉及一种天然多糖基医用抗菌水胶体敷料及其制备方法。
背景技术
水胶体敷料是一种新型的伤口护理敷料,可以适应临床的多种组织渗液伤口。水胶体敷料与传统敷料相比,其优势在于:1.能够长效维持创面的湿润微环境,促进创面的愈合;2.能够持续吸收渗液,减少换药次数,减少换药时所带来的二次创伤;3.完整覆盖创面,隔绝细菌,减少伤口感染的风险。
目前传统的水胶体敷料多为纤维素与橡胶材料共混后制得,分散共混的纤维素提供吸水特性,橡胶材料提供与皮肤粘合性能。虽然纤维素具备一定的吸水特性,能够为伤口提供一个湿润的密闭环境,但是纤维素吸水倍率较低,不能够持续的吸收伤口处的渗液,无法持续的为伤口提供湿润的微环境。201610747962.2,201711328950.7等发明专利申请针对水胶体敷料吸水及保水性差进行了配方改进。但是,由于吸水材料的膨胀特性会导致的皮肤粘合性能下降,使得敷料容易脱落,频繁的更换。因此,具有良好粘合性能及良好的吸水倍率的舒适性水胶体敷料是临床水胶体敷料的迫切需求。
伤口感染是伤口愈合过程中最严重的干扰因素,细菌的滋生使得创面加深、脓肿等,甚至导致败血症及脓毒症等严重症状危害生命。目前现有的水胶体敷料不具备抗菌的功能,仅能通过物理阻隔作用减少伤口与外界的接触,从而减少伤口的感染。但是使用在具有潜在的感染风险或已经有感染的创面时,效果不够理想。
因此,发明一种具有良好皮肤粘合性能、高吸水性以及抗菌的水胶体敷料对医疗用品领域具有积极的意义。
发明内容
有鉴于此,本发明要解决的技术问题在于提供一种天然多糖基医用抗菌水胶体敷料,该水胶体具有交联的结构,具有良好的皮肤粘合力,卓越的吸水能力以及抗菌能力。
本发明具体提供了如下的技术方案:
1、一种天然多糖基医用抗菌水胶体敷料,由背衬支撑层、水胶体层和剥离层构成,所述水胶体层由热塑性弹性体、天然多糖及交联剂组成。
进一步,按质量份数计,所述热塑性弹性体5-10份,天然多糖1-5份,交联剂2-20份。
进一步,所述热塑性弹性体包括苯乙烯类、烯烃类、双烯类、氯乙烯类、氨酯类、酯类、酰胺类、有机氟类、有机硅类、乙烯类;所述苯乙烯类包括苯乙烯-丁二烯-苯乙烯嵌段共聚物、苯乙烯-异戊二烯-苯乙烯嵌段共聚物、苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物、苯乙烯-乙烯-丙烯-苯乙烯型嵌段共聚物,所述烯烃类包括聚烯烃热塑性弹性体、聚丙烯-三元乙丙橡胶硫化弹性体,所述双烯类包括反式-1,4-聚异戊二烯弹性体和反式-1,4-聚丁二烯弹性体,所述氯乙烯类包括聚氯乙烯热塑性弹性体和热塑性氯化聚乙烯,所述氨酯类包括热塑性聚氨酯弹性体,所述酯类包括热塑性聚酯弹性体所述酰胺类包括聚酰胺热塑性弹性体,所述有机硅包括硅橡胶、甲基乙烯基硅橡胶、苯基乙烯硅橡胶、甲基乙烯基硅橡胶、甲基苯基硅橡胶,所述乙烯类包括氯化聚乙烯弹性体、氯磺化聚乙烯弹性体、三元乙丙橡胶。
进一步,所述热塑性弹性体包括苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物、苯乙烯-丁二烯嵌段共聚物、苯乙烯-异戊二烯-苯乙烯嵌段共聚物、三元乙丙橡胶、热塑性聚氨酯弹性体、硅橡胶、热塑性聚酯弹性体、聚烯烃弹性体、聚酰胺热塑性弹性体。
进一步,所述天然多糖包括透明质酸、海藻酸钠、肝素、羧化壳聚糖、羧化纤维素和羧化淀粉。
进一步,所述透明质酸分子量为20万~100万道尔顿;海藻酸钠分子量为10万~80万道尔顿;肝素分子量为2万~60万道尔顿;羧化壳聚糖分子量为5万~50万道尔顿,羧化度为20%~90%;羧化纤维素分子量为2万~40万道尔顿,羧化度为20%~100%;羧化淀粉分子量为40万~200万道尔顿,羧化度为20%~100%。
进一步,所述交联剂为金属化合物和水溶性阳离子化合物;所述金属化合物为多价金属离子盐和多价金属氧化物中的一种或几种的混合;所述水溶性阳离子化合物包括聚季铵盐、聚膦盐、聚丙烯酰胺、聚双胍类、聚乙烯亚胺、聚赖氨酸中的一种或者上述几种的混合。
进一步,所述背衬支撑层包括聚氨酯薄膜、无纺布、纱布、海绵,所述剥离层为格拉辛纸。
吸液倍率18~25倍,保水时间48~72小时,水蒸气透过率20g·m-2·24h-1~30g·m-2·24h-1,可伸展性为1.5N/cm~3N/cm,永久变形0~1%,剥离强度为4N/cm~5N/cm,对大肠埃希菌和金黄色葡萄球菌具有抗菌作用。
2、根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料的制备方法,步骤为:
1)水胶体层的制备:热塑性弹性体加热至熔融,将天然多糖及交联剂加入到熔融的热塑弹性体中,于160℃~250℃下混炼,冷却;
2)水胶体敷料的制备:将背衬层置于底层,将步骤1)的得到的水胶体层均匀地涂于背衬支撑层后,覆盖剥离层,然后加热到熔融,10MPa~20MPa冲压成型。
本发明的有益效果在于:本发明的天然多糖基抗菌水胶体敷料由水胶体层热塑性弹性体、天然多糖及交联剂组成。热塑性弹性体能够为水胶体敷料提供良好的力学支撑,本发明提出利用天然多糖和交联剂形成一种新型的天然多糖三维交联网络作为水胶体的吸水骨架,此种三维网络结构具有溶胀特性,同时三维网络结构的骨架含有大量亲水性的羟基、氨基等基团,可以与水分子形成氢键作用,从而实现了高吸液倍率以及长效保水的特性。同时,此种三维网络结构所形成的大量的互通网络,可以使气体通过,能够实现对创面的透气保湿作用,加速创面愈合。本发明所使用的交联剂为多价金属离子盐以及水溶性聚阳离子化合物,多价金属离子盐中的金属离子以及聚阳离子化合物中的阳离子能够与与带负电的细菌细胞膜产生吸附和扰动作用,能够破坏细菌细胞膜,从而使细菌死亡。
本发明提供的水胶体具有良好的舒适性以及皮肤粘合强度,可伸展性为1.5N/cm~3N/cm,永久变形≤1%,贴近正常皮肤的伸展性,能够提供良好的舒适性;剥离强度为4N/cm~5N/cm,能够对皮肤产生良好的粘合性,不易脱落,同时又不会过度粘连对皮肤及伤口造成损伤,具有良好的舒适性。本发明提供的水胶体吸液倍率≥18倍,保水时间≥48小时,水蒸气透过率>20g·m-2·24h-1,和传统水胶体敷料相比吸水倍率高,保水时间长,能够持续吸收伤口处的组织渗液,维持创面的湿润环境,从而能够长效维持创面的湿润微环境,减少因吸液饱和而导致的频繁换药,从而减少因换药所带来的二次创伤,持续的促进创面愈合。本发明提供的水胶体对常见金黄色葡萄球菌及大肠杆菌具有良好的抗菌作用,同时生物相容性高,能够有效预防伤口的感染,同时也可以用于感染的创面。
附图说明
为了使本发明的目的、技术方案和有益效果更加清楚,本发明提供如下附图:
图1为水胶体敷料琼脂培养基抑菌结果图。
具体实施方式
下面结合附图,对本发明的优选实施例进行详细的描述。
实施例1
将10份苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物(SEBS-YH-506)、2份透明质酸(分子量50万道尔顿)和1份氯化钴置于转速为200r/min的密炼机中,于160℃下混炼30min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于160℃下,10MPa冲压成型,得到水胶体敷料。
实施例2
将5份苯乙烯-异戊二烯-苯乙烯嵌段共聚物(SIS-YH-1126)、2份羧化壳聚糖(分子量20万道尔顿)和4份氯化锌置于转速为150r/min的密炼机中,于150℃下混炼60min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于160℃,10MPa下冲压成型,得到水胶体敷料。
实施例3
将8份三元乙丙橡胶(EPDM-X-3042E)、4份羧化淀粉(分子量100万道尔顿)和4份氯化铁,置于转速为200r/min的密炼机中,于150℃下混炼5min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于150℃,10MPa下冲压成型,得到水胶体敷料。
实施例4
将10份热塑性聚氨酯弹性体(TPU-Soft 35AP)、2份海藻酸钠(分子量50万道尔顿)和3份聚乙烯亚胺(Lupasol WF),置于转速为300r/min的密炼机中,于200℃下混炼30min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于200℃,10MPa下冲压成型,得到水胶体敷料。
实施例5
将3份硅橡胶(TPSiU-V170)、2份肝素(分子量30万道尔顿),6份聚季胺盐-47(HD-2001)置于转速为200r/min的密炼机中,于120℃下混炼5-100min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于190℃,10MPa下冲压成型,得到水胶体敷料。
实施例6
将10份聚酯弹性体(TPEE-40CB)、2份羧化纤维素(分子量20万道尔顿),8份氧化铜置于转速为500r/min的密炼机中,于200℃下混炼30min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于200℃,10MPa下冲压成型,得到水胶体敷料。
实施例7
将10份聚烯烃弹性体(TPO-ENGAGE 8440)、5份透明质酸(分子量30万道尔顿)和20份氧化镁置于转速为80r/min的密炼机中,于210℃下混炼15min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于210℃,10MPa下冲压成型,得到水胶体敷料。
实施例8
将10份聚酰胺热塑性弹性体(TPAE-PEBAX 3533 SA01)、5份海藻酸钠(分子量20万道尔顿)和20份3份聚六甲基双胍(CAS:57028-96-3)置于转速为500r/min的密炼机中,于190℃下混炼60min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于190℃,10MPa下冲压成型,得到水胶体敷料。
实施例9(无交联剂对照组)
将10份聚酰胺热塑性弹性体(TPAE-PEBAX 3533 SA01)、5份海藻酸钠(分子量70万道尔顿)置于转速为500r/min的密炼机中,于190℃下混炼60min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于190℃,10MPa下冲压成型,得到非交联型多糖水胶体敷料。
实施例10(无交联剂对照组)
将10份苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物(SEBS-YH-506)、4份羧化纤维素(分子量40万道尔顿)置于转速为300r/min的密炼机中,于180℃下混炼80min,冷却至室温得到水胶体层;将聚氨酯薄膜剪裁成模具大小,至于模具凹槽中,将上述的水胶体层涂于聚氨酯薄膜上,覆盖格拉辛纸,于190℃,10MPa下冲压成型,得到非交联型多糖水胶体敷料。
实施例11
为了证明本发明的有益效果,对实施例1~10的水胶体敷料与市售羧甲基纤维素类水胶体敷料进行舒适性、持粘性能及剥离强度等性能测试,得到表1的数据,具体实验步骤如下:
舒适性测试参照中华人民共和国医药行业标准YY/T 0471.4-2004。将实施例1-8中的样品裁剪成140mm长,25mm宽的样条,在样条上做两个间距为100mm的平行标记,记录两标记间的距离为L1,将样品标记以外夹于拉伸试验机的两夹头中,以300mm/min的拉伸速度使样品伸长20%,记录最大载荷ML;在此位置保持60s,从夹头上取下样品,松弛300s,重新测量两标记间的距离L2。每个样品重复测试5次,用垂直于裁样方向的样品重复上述步骤。按公式(1)计算可伸展性,按公式(2)计算永久变形。
E=ML/2.5 (1)
E:为可伸展性(N/cm)
ML:最大载荷(N)
PS(%)=(L2-L1)/L1×100 (2)
PS:永久变形;
L1:拉伸前两标记间的距离;
L2:拉伸后两标记间的距离
持粘性能测试参照中华人民共和国医药行业标准YY/T 1293.4-2016接触性创面敷料第四部分:水胶体敷料。将实施例1~8中的样品一端的粘贴面与不锈钢板的清洁表面接触,并确保其与不锈钢板之间没有气泡,端部的整个宽度与距钢板端面25mm处对齐,两边平行于钢板的长边。试样的未粘贴端悬于钢板该端面以外。用滚子向试样粘贴部分施加压力,以约60cm/min的速度沿试样长度方向滚压四次,并使其在标准大气压下停放10min。在试样端线部做一标记线,在试样的悬挂端按每厘米宽度0.8N(80g)贴一重物,施力要均匀分布于整个带宽上。将钢板悬挂于36℃~38℃热空气烘箱内30min,使钢板与垂直面呈2°倾斜,以防止试样与钢板剥离,并能使重物悬挂。按照上述步骤重复5次,
剥离强度的测试参照中华人民共和国医药行业标准YY/T 1293.4-2016接触性创面敷料第四部分:水胶体敷料。将实施例1~8中的样品贴于不锈钢板的清洁表面的中央,两边平行于钢板的两个长边。用滚子向试样粘贴部分施加压力,以约60cm/min的速度沿试样长度方向滚压四次。使其在标准大气压下停放10min。用力值读数范围在满量程的15%~85%之间的适宜的测力仪器,测定从钢板剥离试样所需的力(施力角为180°,剥离速度为(270mm/min~330mm/min)。观测第一个25mm长度处施加的作用力,每30mm2)观测一次作用力,取六次读数的平均值。按照上述实验步骤重复5次,得到表1的数据。
表1水胶体敷料的物理性能
YY/T 1293.4-2016接触性创面敷料第四部分:水胶体敷料要求水胶体敷料的可伸展性≤4.0N/cm,永久变形≤5%,持粘性≤2.5mm,剥离强度≥1N/cm。
从表1可以看出:
本发明的水胶体敷料的可伸展性为1.5N/cm~3N/cm,与非交联型多糖水胶体敷料(实施例9和实施例10)以及市售水胶体敷料相当。
发明的水胶体敷料永久变形≤1%,均符合行业标准,而非交联型多糖水胶体敷料(实施例9和实施例10)以及市售水胶体敷料的永久变形大于1%,表明本发明的水胶体由于使用交联剂交联了天然多糖后,具有良好的可伸展性,能够良好贴合皮肤并跟随皮肤伸展和运动。
剥离强度说明了水胶体敷料对于皮肤的粘合性,当剥离强度较高时说明水胶体能够对皮肤产生良好的粘合性,不易脱落。本发明的水胶体敷料剥离强度为4~5N/cm,大于非交联型多糖水胶体敷料(实施例9和实施例10)以及市售水胶体敷料(2N/cm左右)。这是由于本发明的水胶体敷料通过将所添加的天然多糖和阳交联剂交联,在胶体内部产生了交联内聚力,同时天然多糖及阳交联剂能够对皮肤组织上带有的大量氨基、酰胺和羟基形成次级键作用从而能够对皮肤产生更好的粘合性及舒适性。
实施例12
为了证明本发明的有益效果,对实施例1~10的水胶体敷料与市售羧甲基纤维素类水胶体敷料进行液体吸收性能测试,得到表2数据,具体试验情况如下:
吸液性能测试:将实施例1~8中的样品裁剪成2cm×2cm的样条,称其质量为W1,置于90mm的培养皿内,加入足量的水,放入37℃干燥箱中,24h后用镊子夹持样品的一端,悬垂30s,用滤纸轻轻擦去表面的水分,记录样品的质量为W2。每个样品重复3次。吸液倍数按照公式(3)计算:
X=(W2-W1)/W1 (3)
X:吸液倍数;
W1:样品的质量(g);
W2:24h后样品的质量(g)。
保水性能测试:将实施例1~8中的样品裁剪成2cm×2cm的样条,称其质量为W1,将其浸泡于水中,使其吸水饱和,将样品放入37℃干燥箱中,每隔30min中取出称样品的质量,直至完全失水,质量变为W1,记录时间T,即为水胶体敷料的保水时间。
表2吸水和保水性能测试结果
水胶体敷料的吸液性能主要用于评价水胶体敷料对于创面渗液的吸收性能,保水性能用于评价水胶体敷料维持创面湿润环境的能力。从表2中可以看出:
实施例1~8中的水胶体敷料的吸液倍数和保水时间明显优于实施例9、10(4.6倍以上)和市售水胶体敷料(6倍以上),这主要得益于交联后的水胶体层在吸收液体后能够形成三维网络的水凝胶结构,牢牢的锁住水分子,减少水分子的流失。能够持续吸收伤口处的组织渗液,维持创面的湿润环境,利于创面的愈合。
实施例13
为了证明本发明的有益效果,对实施例1~10的水胶体敷料与市售羧甲基纤维素类水胶体敷料进行水蒸气透过率性能测试,得到表3数据,具体试验情况如下:
水蒸气透过率主要用于评价接触水蒸气时敷料的水蒸气透过性能。液体聚集会对皮肤的完好性造成严重后果,敷料宜具有充分的水蒸气渗透性,以防止敷料下液体的集聚。
水蒸气透过率的测试参照中华人民共和国医药行业标准YY/T 0471.2-2004,接触性创面敷料试验方法第2部分:透气膜敷料水蒸气透过率。将实施例1~8中的样品裁剪成面积为10cm2的圆片至于装有20mL水清洁干燥圆筒上方(敷料与水面的间距为5mm),边缘部分用凡士林密封,称取圆筒连同敷料的质量记为W1,将整个体系放于37℃的干燥箱中(保证相对湿度<20%)24h后取出容器,并记录容器样品和液体的质量为W2。水蒸气透过率按照公式(4)计算:
X=(W1-W2)×1000 (4)
X:水蒸气透过率(MVTR),单位为克每平方米每24小时(g·m-2·24h-1)
W1:容器、样品、液体的质量(g)
W2:24h后容器、样品、液体的质量(g)
表3水蒸气透过率测试结果
从表3可以看出:
实施例1~8中的水胶体敷料的水蒸气透过率>20g·m-2·24h-1,具有充分的水蒸气渗透性,有利于创面的愈合,其水蒸气透过率远大于非交联型多糖水胶体敷料(实施例9和实施例10,仅为10g·m-2·24h-1左右),这主要得益于交联后所行程的三维网络结构,三维网络结构的形成了大量互通网络,可以使气体通过,而三维网络结构的骨架含有大量亲水性的羟基、氨基等基团,可以与水分子形成氢键作用,从而实现透气缩水的效果。
实施例14
为了证明本发明的有益效果,对实施例1~10的水胶体敷料与市售羧甲基纤维素类水胶体敷料进行抗菌性能测试,具体试验情况如下:
(1)试样的制备
将实施例5~8中样品剪成1×1cm大小样片,0.75g分装包好。
(2)菌液的制备
试验菌株:金黄色葡萄球菌(ATCC 25923)和大肠埃希菌(ATCC25922)
菌液的培养:取菌株第3~14代的营养琼脂培养基斜面新鲜培养物(18~24h),用5mL 0.03mol/L的磷酸盐缓冲液(以下简称PBS)洗下菌苔,使菌悬浮均匀后用上述PBS稀释至所需浓度。
(3)抑菌试验
称取被试样片(剪成1cm×l cm大小)0.75g分装包好
将0.75g样片放入一个250mL的三角烧瓶中,分别加人70mL PBS和5mL菌悬液,使菌悬液在PBS中的浓度为2×105CFU/mL。
将三角烧瓶固定于振荡摇床上,以150r/min振摇12h。
取0.5mL振摇后的样液,或用PBS做适当稀释后的样液,以琼脂倾注法接种平皿,进行菌落计数。
同时设对照样片组和不加样片组,对照样片组的对照样片与被试样片同样大小但不含抗菌成分。抑菌率按照公式(5)计算
X=(A-B)/A×100% (5)
X:抑菌率,%;
A:不加样品组菌落个数;
B:实验组菌落个数。
(4)结果评判
根据平板内菌落的个数判定实施例1~8的水胶体敷料的抗菌性能,得到图1和表4。
表4抗菌性能测试结果
从图1和表4数据可以看出:实施例1~8水胶体敷料对大肠埃希菌E.coli、金黄色葡萄球菌S.aureus具有良好的抗菌效果,抑菌率达99.9%以上,而非交联型多糖水胶体敷料(实施例9和实施例10)及市售水胶体敷料无抗菌性。
最后说明的是,以上优选实施例仅用以说明本发明的技术方案而非限制,尽管通过上述优选实施例已经对本发明进行了详细的描述,但本领域技术人员应当理解,可以在形式上和细节上对其作出各种各样的改变,而不偏离本发明权利要求书所限定的范围。
Claims (7)
1.一种天然多糖基医用抗菌水胶体敷料,其特征在于,由背衬支撑层、水胶体层和剥离层构成,所述水胶体层由热塑性弹性体、天然多糖及交联剂组成;所述交联剂为水溶性阳离子化合物;所述水溶性阳离子化合物包括聚季铵盐、聚膦盐、聚丙烯酰胺、聚双胍类、聚乙烯亚胺、聚赖氨酸中的一种或者上述几种的混合;其吸液倍率18~25倍,保水时间48~72小时,水蒸气透过率20g·m-2·24h-1~30g·m-2·24h-1,可伸展性为1.5N/cm~3N/cm,永久变形0~1%,剥离强度为4N/cm~5N/cm,对大肠埃希菌和金黄色葡萄球菌具有抗菌作用;所述的一种天然多糖基医用抗菌水胶体敷料的制备方法,步骤为:1)水胶体层的制备:热塑性弹性体加热至熔融,将天然多糖及交联剂加入到熔融的热塑弹性体中,于160℃~250℃下混炼,冷却;2)水胶体敷料的制备:将背衬层置于底层,将步骤1)的得到的水胶体层均匀地涂于背衬支撑层后,覆盖剥离层,然后加热到熔融,10MPa~20MPa冲压成型。
2.根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于,按质量份数计,所述热塑性弹性体5-10份,天然多糖1-5份,交联剂2-20份。
3.根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于,所述热塑性弹性体包括苯乙烯类、烯烃类、双烯类、氯乙烯类、氨酯类、酯类、酰胺类、有机氟类、有机硅类、乙烯类;所述苯乙烯类包括苯乙烯-丁二烯-苯乙烯嵌段共聚物、苯乙烯-异戊二烯-苯乙烯嵌段共聚物、苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物、苯乙烯-乙烯-丙烯-苯乙烯型嵌段共聚物,所述烯烃类包括聚烯烃热塑性弹性体、聚丙烯-三元乙丙橡胶硫化弹性体,所述双烯类包括反式-1,4-聚异戊二烯弹性体和反式-1,4-聚丁二烯弹性体,所述氯乙烯类包括聚氯乙烯热塑性弹性体和热塑性氯化聚乙烯,所述氨酯类包括热塑性聚氨酯弹性体,所述酯类包括热塑性聚酯弹性体所述酰胺类包括聚酰胺热塑性弹性体,所述有机硅包括硅橡胶、甲基乙烯基硅橡胶、苯基乙烯硅橡胶、甲基乙烯基硅橡胶、甲基苯基硅橡胶,所述乙烯类包括氯化聚乙烯弹性体、氯磺化聚乙烯弹性体、三元乙丙橡胶。
4.根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于,所述热塑性弹性体包括苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物、苯乙烯-丁二烯嵌段共聚物、苯乙烯-异戊二烯-苯乙烯嵌段共聚物、三元乙丙橡胶、热塑性聚氨酯弹性体、硅橡胶、热塑性聚酯弹性体、聚烯烃弹性体、聚酰胺热塑性弹性体。
5.根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于,所述天然多糖包括透明质酸、海藻酸钠、肝素、羧化壳聚糖、羧化纤维素和羧化淀粉。
6.根据权利要求5所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于,所述透明质酸分子量为20万~100万道尔顿;海藻酸钠分子量为10万~80万道尔顿;肝素分子量为2万~60万道尔顿;羧化壳聚糖分子量为5万~50万道尔顿,羧化度为20%~90%;羧化纤维素分子量为2万~40万道尔顿,羧化度为20%~100%;羧化淀粉分子量为40万~200万道尔顿,羧化度为20%~100%。
7.根据权利要求1所述的一种天然多糖基医用抗菌水胶体敷料,其特征在于:所述背衬支撑层包括聚氨酯薄膜、无纺布、纱布、海绵,所述剥离层为格拉辛纸。
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1095582A (zh) * | 1993-05-23 | 1994-11-30 | 常州卫生材料厂 | 医用胶布及其制造工艺 |
EP1701677A2 (en) * | 2003-08-20 | 2006-09-20 | Wahi, Ashok L. | Electrostatically charged nasal application product with increased strength |
CN101502667A (zh) * | 2009-03-13 | 2009-08-12 | 东华大学 | 一种医用壳聚糖透明水凝胶创伤敷料及其制备和应用 |
CN102302798A (zh) * | 2011-08-18 | 2012-01-04 | 苏州美迪斯医疗运动用品有限公司 | 水胶体敷料及其制备方法 |
CN102600019A (zh) * | 2012-03-09 | 2012-07-25 | 烟台万利医用品有限公司 | 一种医用水凝胶敷料及其制备方法 |
JP5147207B2 (ja) * | 2006-09-22 | 2013-02-20 | 帝國製薬株式会社 | ハイドロゲル創傷被覆材 |
CN104784741A (zh) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | 壳聚糖功能性水胶体医用敷料 |
-
2019
- 2019-01-16 CN CN201910038144.9A patent/CN109549778B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1095582A (zh) * | 1993-05-23 | 1994-11-30 | 常州卫生材料厂 | 医用胶布及其制造工艺 |
EP1701677A2 (en) * | 2003-08-20 | 2006-09-20 | Wahi, Ashok L. | Electrostatically charged nasal application product with increased strength |
JP5147207B2 (ja) * | 2006-09-22 | 2013-02-20 | 帝國製薬株式会社 | ハイドロゲル創傷被覆材 |
CN101502667A (zh) * | 2009-03-13 | 2009-08-12 | 东华大学 | 一种医用壳聚糖透明水凝胶创伤敷料及其制备和应用 |
CN102302798A (zh) * | 2011-08-18 | 2012-01-04 | 苏州美迪斯医疗运动用品有限公司 | 水胶体敷料及其制备方法 |
CN102600019A (zh) * | 2012-03-09 | 2012-07-25 | 烟台万利医用品有限公司 | 一种医用水凝胶敷料及其制备方法 |
CN104784741A (zh) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | 壳聚糖功能性水胶体医用敷料 |
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