CN109533418A - It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment - Google Patents
It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment Download PDFInfo
- Publication number
- CN109533418A CN109533418A CN201811397066.3A CN201811397066A CN109533418A CN 109533418 A CN109533418 A CN 109533418A CN 201811397066 A CN201811397066 A CN 201811397066A CN 109533418 A CN109533418 A CN 109533418A
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- China
- Prior art keywords
- reagent
- bottle
- container
- reagent container
- pumped
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
Abstract
The present invention relates to the reagent container technical fields that non-clean environment guarantees sterile replacement, it is in particular a kind of to guarantee the reagent container of sterile replacement in non-clean environment, the following steps are included: S1, reagent container is connected to the system of being pumped into and started and is pumped into system, the system of being pumped into can successively clean this section of pipeline between the pump housing-filling head by the switching on the road Beng Hefa using cleaning solution, thimerosal etc.；S2 injects reagent: after one bottle of reagent is used up, when needing replacing new reagent, reagent container is connected to the system of being pumped into, the container of new reagent is put into agent bin by the reagent bottle more renewed, if it is the reagent for needing temperature control, need to open the temperature control module of agent bin；S3, not being due to installation environment is gnotobasis, after connecting in such a case.The present invention does not need the reagent container installed under high-level gnotobasis (such as grade A environment), and the reagent container can guarantee sterile injection reagent after installation, effectively raise the efficiency of production.
Description
Technical field
The present invention relates to the reagent container technical field that non-clean environment guarantees sterile replacement, it is specially a kind of can be non-clean
The reagent container of the sterile replacement of net conditions warrant.
Background technique
In industries such as drug production, filling, the cell productions of drug, need that entire production environment is maintained to be in germ-free condition
Under.Space of the entire production environment in a sealing, isolation.And the reagent of some large capacities is since volume is larger, it is difficult
To be placed directly into sterile insulating space.Usually these medicaments are placed on the outside of an insulating space, then pass through pump
Enter system to be pumped into shielding system medicament.Since medicament is placed on outside shielding system, be in ambient non-sterile, how
Drug-injecting system simultaneously guarantees sterile, is the challenge of industry, the container of conventional splendid attire medicament, it is necessary to open under clean environment
Lid uses, or combines using disposable pipeline and with sterile bulb-tubulating machine.When using this container, in order to guarantee reagent
Piping connection, the gnotobasis in use process, common practice has so several: a kind of factory to build high-cleanness, high
Room allows outside isolator and is also maintained at higher gnotobasis, such as B grades of environment.Use disposable piping connection reagent bottle (bag)
And injection carries out disinfection after each replacement.This scheme needs the workshop of high-cleanness, high, expenditure of construction and maintenance
Expense is all more high；Another method is the container of splendid attire medicament to be connected to the fixing pipe road with decontamination system, often
Using purified water, compressed air, injection water, steam etc. after the completion of the production of one batch, successively carry out disinfection sterilizing to pipeline.This
Kind scheme needs a sterilization module, and cost is not low, and occupied area is huge.
In conclusion how to design a kind of container of new installed reagents, can easily make in ambient non-sterile
With, and guarantee it is sterile in use process, become at present need urgently solve the problems, such as.
Summary of the invention
It can guarantee the reagent container of sterile replacement in non-clean environment the purpose of the present invention is to provide a kind of, on solving
State the problem of proposing in background technique.
To achieve the above object, the invention provides the following technical scheme:
It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment, comprising the following steps:
Reagent container is connected to the system of being pumped into and starting is pumped into system by S1, and the system of being pumped into can cutting by the road Beng Hefa
It changes, this section of pipeline between the pump housing-filling head is successively cleaned using cleaning solution, thimerosal etc.；
S2 injects reagent: after one bottle of reagent is used up, when needing replacing new reagent, reagent container being connected to and is pumped into
The container of new reagent is put into agent bin by system, the reagent bottle more renewed, if it is the reagent for needing temperature control, needs to open
The temperature control module of agent bin；
S3, not being due to installation environment is gnotobasis, after connecting in such a case, agent bin, patch panel, pump
This part pipeline between body will receive pollution, open back flush program, after program starting, pumping system meeting switching valve road,
Successively using this section of pipeline between the reagents cleaning reagent storehouse-patch panel-pump housings such as thimerosal, cleaning solution；
S4, reagent it is canned: reversal valve connection pass joint and reagent bottle under initial conditions, reagent manufacturer by reagent by
After connector is filled into reagent bottle, the direction of switch valve；
S5, install reagent bottle: user, can be under non-clean state, by reagent container when using reagent
Connector is connected in patch panel；
S6, the irrigation and disinfection of pipeline: due to being installed under non-clean state, this section of reagent container reversal valve to connector
Pipeline is contaminated, only needs to invert pumping system at this time, using this section of pipeline of liquid wash, so that this part pipeline be allowed to reach
To germ-free condition；
S7, switch valve, normal to inject: after the completion of flushing, switch valve is connected to connector with reagent bottle.
Preferably, the S1, reagent container are made of reagent bottle, rubbish bottle, reversal valve, connector.The reagent container is
The containers such as sack, bottle, bucket and first filling reagent are to reagent bag (bottle) in, then with pipe-connecting modes such as sterile bulb-tubulating machines, trying
Agent and reversal valve, rubbish bottle connect together.
Preferably, the S4, for reversal valve one is connection connector and reagent bottle, another kind is to be connected to connector and rubbish bottle,
And when using the time, it is used to connect between patch panel.
Preferably, the S1, being pumped into system, there is special valve road to design, and be pumped into system can support multiple channels it
Between switching, one be pumped into system just possess injection plurality of reagents ability.
Preferably, the S4, inside just pre- filling reagent when reagent bottle is factory.
Preferably, the S1, in reagent container the factory of rubbish bottle when be empty bag.
Preferably, the S3, agent bin have temperature control system.
Compared with prior art, the beneficial effects of the present invention are:
1, in the present invention, build the workshop of high-cleanness, high by designing to avoid, allow outside isolator be also maintained at it is higher
Gnotobasis disappeared after each replacement using disposable piping connection reagent bottle (bag) and injection such as B grades of environment
Poison, needs the workshop of high-cleanness, high, so that it is all more high to reduce its expenditure of construction and standing charges.
2, it in the present invention, is avoided by design and the container of splendid attire medicament is connected to the fixation pipeline with decontamination system
On, using purified water, compressed air, injection water, steam etc. after the completion of the production of each batch, successively carries out disinfection and go out to pipeline
Bacterium needs a sterilization module, and cost is not low, and occupied area is huge, to reduce the cost of engineering, occupied area makes
With.
3, in the present invention, method is changed by design, structure is simple, and service performance is strong, and low cost, and occupied area is small,
The reagent container installed under high-level gnotobasis (such as grade A environment) is not needed, and the reagent container can guarantee peace
Sterile injection reagent after dress, so that high efficiency is carried out, the production of sterile mode.
Detailed description of the invention
Fig. 1 is the principle of the present invention figure；
Fig. 2 is that the present invention uses figure.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments, is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of technical solution referring to FIG. 1-2:
It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment, comprising the following steps:
Reagent container is connected to the system of being pumped into and starting is pumped into system by S1, and the system of being pumped into can cutting by the road Beng Hefa
It changes, successively cleans this section of pipeline between the pump housing-filling head using cleaning solution, thimerosal etc., its role is to can guarantee
It is germ-free condition before injecting reagent；
S2 injects reagent: after one bottle of reagent is used up, when needing replacing new reagent, reagent container being connected to and is pumped into
The container of new reagent is put into agent bin by system, the reagent bottle more renewed, if it is the reagent for needing temperature control, needs to open
The temperature control module of agent bin works and is to extend the storage time of reagent；
S3, not being due to installation environment is gnotobasis, after connecting in such a case, agent bin, patch panel, pump
This part pipeline between body will receive pollution, open back flush program, after program starting, pumping system meeting switching valve road,
Successively using this section of pipeline between the reagents cleaning reagent storehouse-patch panel-pump housings such as thimerosal, cleaning solution, act on
Sterile injection after guaranteeing reagent replacement；
S4, reagent it is canned: reversal valve connection pass joint and reagent bottle under initial conditions, reagent manufacturer by reagent by
After connector is filled into reagent bottle, the direction of switch valve completely cuts off contact of the reagent in reagent bottle with outside, guarantees the nothing of reagent
Bacterium state；
S5, install reagent bottle: user, can be under non-clean state, by reagent container when using reagent
Connector is connected in patch panel；
S6, the irrigation and disinfection of pipeline: due to being installed under non-clean state, this section of reagent container reversal valve to connector
Pipeline is contaminated, only needs to invert pumping system at this time, using this section of pipeline of liquid wash, the contaminated fluid meeting that rinses out
Into rubbish bottle；
S7, switch valve, normal to inject: after the completion of flushing, switch valve is connected to connector with reagent bottle, pumps at this time
Reagent can be formally injected into inside isolator by system.
The S1, reagent container are made of reagent bottle, rubbish bottle, reversal valve, connector.The reagent container is sack, bottle
The containers such as son, bucket and first filling reagent are in reagent bag (bottle), then with pipe-connecting modes such as sterile bulb-tubulating machines, reagent and commutation
Valve, rubbish bottle connect together.
The S4, for reversal valve one is connection connector and reagent bottle, another kind is connection connector and rubbish bottle, and is used
When the time, it is used to connect between patch panel.
The S1 is pumped into system and designs with special valve road, and is pumped into system to support cutting between multiple channels
It changes, one is pumped into the ability that system just possesses injection plurality of reagents, works and is to switch mutually between multiple channels, together
When be both able to achieve positive injection, be also able to achieve inverse injection.
The S4, inside just pre- filling reagent when reagent bottle is factory.
The S1, in reagent container the factory of rubbish bottle when be empty bag, work and be for when accommodating flushing pipeline
Rubbish solution.
The S3, agent bin have temperature control system, so that large capacity reagent be allowed to be stored in agent bin for a long time, and maintain to try
The potency of agent, agent bin can be bottled reagent, are also possible to packed reagent for storing large capacity reagent.
Specific embodiment:
Step 1: reagent container is connected to the system of being pumped into, the reagent bottle more renewed；
The container of new reagent: being put into agent bin by step 2, if it is the reagent for needing temperature control, needs to open agent bin
Temperature control module；
Step 3: not being due to installation environment is gnotobasis, after connecting in such a case, agent bin, wiring face
This part pipeline between plate, the pump housing will receive pollution, open back flush program, after program starting, pumping system can switch
Valve road, successively using this section of pipeline between the reagents cleaning reagent storehouse-patch panel-pump housings such as thimerosal, cleaning solution；
Step 4: reagent it is canned: under initial conditions reversal valve connection pass joint and reagent bottle, reagent manufacturer will try
After agent is filled into reagent bottle by connector, the direction of switch valve；
Step 5: installation reagent bottle: user can be held reagent under non-clean state when using reagent
The connector of device is connected in patch panel；
Step 6: the irrigation and disinfection of pipeline: due to being installed under non-clean state, reagent container reversal valve to connector
This section of pipeline is contaminated, only needs to invert pumping system at this time, uses this section of pipeline of liquid wash；
Step 7: switch valve, normal to inject: after the completion of flushing, switch valve is connected to connector with reagent bottle.
In this process present invention, the workshop of high-cleanness, high is built by designing to avoid, allows outside isolator and is also maintained at
Higher gnotobasis is carried out after each replacement such as B grades of environment using disposable piping connection reagent bottle (bag) and injection
Disinfection, needs the workshop of high-cleanness, high, so that it is all more high to reduce its expenditure of construction and standing charges, passes through design
It avoids and the container of splendid attire medicament is connected to the fixing pipe road with decontamination system, used after the completion of the production of each batch
Purified water, compressed air, injection water, steam etc. successively carry out disinfection sterilizing to pipeline, need a sterilization module, cost is not
It is low, and occupied area is huge, to reduce the cost of engineering, the use of occupied area changes method, structure letter by design
Single, service performance is strong, and low cost, and occupied area is small, does not need to be pacified under high-level gnotobasis (such as grade A environment)
The reagent container of dress, and the reagent container can guarantee sterile injection reagent after installation, so that high efficiency is carried out, sterile mode
Production.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. a kind of can guarantee the reagent container of sterile replacement in non-clean environment, which comprises the following steps:
S1, reagent container is connected to the system of being pumped into and started be pumped into system, the system of being pumped into can by the switching on the road Beng Hefa, according to
Secondary this section of pipeline using between the cleaning pump housing-filling head such as cleaning solution, thimerosal；
S2 injects reagent: after one bottle of reagent is used up, when needing replacing new reagent, reagent container being connected to the system of being pumped into,
The container of new reagent is put into agent bin by the reagent bottle more renewed, if it is the reagent for needing temperature control, needs to open agent bin
Temperature control module；
S3, due to installation environment be not be gnotobasis, in such a case connect after, agent bin, patch panel, the pump housing it
Between this part pipeline will receive pollution, open back flush program, after program starting, pumping system can switching valve road, successively
Use this section of pipeline between the reagents such as thimerosal, cleaning solution cleaning reagent storehouse-patch panel-pump housing；
S4, reagent it is canned: reversal valve connection pass joint and reagent bottle under initial conditions, reagent manufacturer is by reagent by connector
After being filled into reagent bottle, the direction of switch valve；
S5, install reagent bottle: user, can be under non-clean state, by the connector of reagent container when using reagent
It is connected in patch panel；
S6, the irrigation and disinfection of pipeline: due to being installed under non-clean state, reagent container reversal valve to this section of pipeline of connector
It is contaminated, it only needs to invert pumping system at this time, uses this section of pipeline of liquid wash；
S7, switch valve, normal to inject: after the completion of flushing, switch valve is connected to connector with reagent bottle.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 2. according to claim 1, which is characterized in that
The S1, reagent container are made of reagent bottle, rubbish bottle, reversal valve, connector.The reagent container is that sack, bottle, bucket etc. hold
Device and first filling reagent are in reagent bag (bottle), then with pipe-connecting modes such as sterile bulb-tubulating machines, reagent and reversal valve, rubbish bottle
It connects together.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 3. according to claim 1, which is characterized in that
The S4, reversal valve is one is connection connector and reagent bottle, and another kind is connection connector and rubbish bottle, and when the use time,
It is used to connect between patch panel.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 4. according to claim 1, which is characterized in that
The S1, being pumped into system, there is special valve road to design, and is pumped into system and can support switching between multiple channels, a pump
Enter the ability that system just possesses injection plurality of reagents.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 5. according to claim 1, which is characterized in that
The S4, inside just pre- filling reagent when reagent bottle is factory.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 6. according to claim 1, which is characterized in that
The S1, in reagent container the factory of rubbish bottle when be empty bag.
A kind of it can guarantee the reagent container of sterile replacement in non-clean environment 7. according to claim 1, which is characterized in that
The S3, agent bin have temperature control system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811397066.3A CN109533418A (en) | 2018-11-22 | 2018-11-22 | It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811397066.3A CN109533418A (en) | 2018-11-22 | 2018-11-22 | It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109533418A true CN109533418A (en) | 2019-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811397066.3A Pending CN109533418A (en) | 2018-11-22 | 2018-11-22 | It is a kind of to guarantee the reagent container of sterile replacement in non-clean environment |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006117310A (en) * | 2004-10-25 | 2006-05-11 | Bokuson Kogyo Kk | Dispensing device for foaming beverage |
| CN1835887A (en) * | 2003-08-11 | 2006-09-20 | 斯帕卡斯·比尔 | Dispensing system for beverages and method for cleaning a dispensing system |
| CN202063919U (en) * | 2011-05-20 | 2011-12-07 | 成都天邦生物制品有限公司 | Sterile sampling system |
| AU2012244207A1 (en) * | 2011-10-26 | 2013-05-09 | Hoshizaki Lancer Pty Ltd | Beverage Trade-Out System and Method |
| CN206145435U (en) * | 2016-10-28 | 2017-05-03 | 内蒙古伊利实业集团股份有限公司 | Aseptic connector and aseptic connecting device |
| CN206940913U (en) * | 2017-07-10 | 2018-01-30 | 山东新华医疗器械股份有限公司 | A kind of feeding pipeline cleaning and sterilizing system for high-flux cell culture systems |
-
2018
- 2018-11-22 CN CN201811397066.3A patent/CN109533418A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1835887A (en) * | 2003-08-11 | 2006-09-20 | 斯帕卡斯·比尔 | Dispensing system for beverages and method for cleaning a dispensing system |
| JP2006117310A (en) * | 2004-10-25 | 2006-05-11 | Bokuson Kogyo Kk | Dispensing device for foaming beverage |
| CN202063919U (en) * | 2011-05-20 | 2011-12-07 | 成都天邦生物制品有限公司 | Sterile sampling system |
| AU2012244207A1 (en) * | 2011-10-26 | 2013-05-09 | Hoshizaki Lancer Pty Ltd | Beverage Trade-Out System and Method |
| CN206145435U (en) * | 2016-10-28 | 2017-05-03 | 内蒙古伊利实业集团股份有限公司 | Aseptic connector and aseptic connecting device |
| CN206940913U (en) * | 2017-07-10 | 2018-01-30 | 山东新华医疗器械股份有限公司 | A kind of feeding pipeline cleaning and sterilizing system for high-flux cell culture systems |
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Application publication date: 20190329 |