CN109529104A - Promote gel dressing of cell Proliferation migration and preparation method thereof, application method - Google Patents

Promote gel dressing of cell Proliferation migration and preparation method thereof, application method Download PDF

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Publication number
CN109529104A
CN109529104A CN201910052370.2A CN201910052370A CN109529104A CN 109529104 A CN109529104 A CN 109529104A CN 201910052370 A CN201910052370 A CN 201910052370A CN 109529104 A CN109529104 A CN 109529104A
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gel dressing
adjusting agent
gel
recombinant human
wound
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CN201910052370.2A
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Inventor
钱松
李海航
徐达鹏
梁亮
朱世辉
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Chuangfu (changzhou) Biotechnology Co Ltd
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Chuangfu (changzhou) Biotechnology Co Ltd
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Priority to CN201910052370.2A priority Critical patent/CN109529104A/en
Publication of CN109529104A publication Critical patent/CN109529104A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to bioengineering fields, and in particular to a kind of gel dressing and preparation method thereof for promoting cell Proliferation migration, application method.Wherein this gel dressing includes: the aquogel system containing recombinant human collagen albumen；The aquogel system is suitable for forming hydrogel state on surface of a wound surface.Gel dressing of the invention can form hydrogel state on surface of a wound surface by aquogel system, prevent the surface of a wound exposed or gel dressing covering is uneven；The recombinant human collagen albumen in hydrogel can give nutrient necessary to skin layer simultaneously, reinforce the collagen activity in skin, promote cell Proliferation migration, to promote the metabolism of skin histology, improve healing speed.

Description

Promote gel dressing of cell Proliferation migration and preparation method thereof, application method
Technical field
The present invention relates to bioengineering, and in particular to it is a kind of promote cell Proliferation migration gel dressing and its preparation side Method, application method.
Background technique
Skin is covered in entire body surface, is the maximum organ of body.Skin is by water, protein, fatty acid and inorganic Salt composition, can be divided into three layers: epidermis, corium and subcutaneous tissue from inside to outside.Wherein water content is 50-70%, and 10% in skin Outer layer, 65% in skin inner layer, and more higher toward deep skin moisture content；Protein content is 25% or so；Fatty acid, nothing Machine salt content is 3-5%.
For skin wound, especially the moisture of burn wound easily largely scatters and disappears, the loss of protein and salinity It is more serious, it will cause electrolyte (liquid) and protein losses.Thus the dressing of covering burn wound is proposed very high Requirement, not only to play the role of prevention infection, Wound treatment and Nutritional Nursing Care, also to play and adjust water, electrolyte and acid Soda balance, and the effect of supplement protein.
Summary of the invention
The object of the present invention is to provide gel dressings of a kind of promotion cell Proliferation migration and preparation method thereof, user Method.
In order to solve the above-mentioned technical problems, the present invention provides a kind of gel dressings, comprising: contains recombinant human collagen albumen Aquogel system；The aquogel system is suitable for forming hydrogel state on surface of a wound surface.
Further, the concentration of the recombinant human collagen albumen is 10-300g/L.
Further, the aquogel system further include: thickener, pH adjusting agent, amino acid, sugar and appropriate deionization Water.
Further, the thickener includes: xanthan gum, chitosan, hyaluronic acid, sodium carboxymethylcellulose, gelatin, poly- third One or more of olefin(e) acid sodium.
Further, the concentration of each component is 1-50g/L in the thickener.
Further, the pH adjusting agent includes: NaCl:110-150mmol/L；KCl:2.0-3.0mmol/L；Na2HPO4: 7-13mmol/L；And KH2PO4: 1.8-2.4mmol/L.
Further, the pH adjusting agent includes: NaCl:110-150mmol/L；KCl:2-5mmol/L；NaH2PO4: 0.3- 0.6mmol/L；And Na2HPO4: 0.3-0.8mmol/L.
Further, the sugar includes one or more of glucose, fructose；Wherein the glucose and fructose is dense Degree is 1-50g/L.
Another aspect, the present invention also provides a kind of application methods of gel dressing, comprising: is creating gel dressing mulching Hydrogel state is formed it on face；And semi-permeable membrane is closed in hydrogel surface mulching.
On the other hand, the present invention also provides a kind of preparation method of gel dressing, the gel dressing is suitable for sterile life It produces and packs.
The invention has the advantages that the aquogel system in gel dressing of the invention can form water on surface of a wound surface Gel state, prevents the surface of a wound exposed or gel dressing covering is uneven；The recombinant human collagen albumen in hydrogel can be tieed up simultaneously The normal physiological function for protecting cell, tissue, organ, and plays an important role with injury repair, i.e. recombinant human collagen albumen can be with Nutrient necessary to skin layer is given, the collagen activity in skin is reinforced, promotes cell Proliferation migration, to promote skin The metabolism of skin tissue improves healing speed.
Specific embodiment
Embodiment 1
The present embodiment 1 provides a kind of gel dressing, comprising: the aquogel system containing recombinant human collagen albumen；It is described Aquogel system is suitable for forming hydrogel state on surface of a wound surface.
Optionally, the recombinant human collagen albumen be such as, but not limited to concentration be 10-300g/L, preferably 100g/L, 250g/L。
Optionally, such as, but not limited to application No. is weigh in 201310033299.6 patent for the recombinant human collagen albumen Benefit require 1 disclosed in humanization genetic recombination collagen.Compared to more traditional collagen (object collagen, prokaryotic micro-organisms recombination Collagen), the recombinant human collagen albumen is the recombinant collagen of full-length human, and it is anti-to avoid animal collagen bring immunological rejection It answers, has prevented bio-safety hidden danger, technical process is environmentally friendly, and endotoxin-free hidden danger.
Aquogel system in the gel dressing of the present embodiment 1 can form hydrogel state on surface of a wound surface, prevent from creating Face is exposed or gel dressing covering is uneven；The recombinant human collagen albumen in hydrogel can safeguard cell, tissue, organ simultaneously Normal physiological function, and play an important role with injury repair, i.e., it is required can to give skin layer institute for recombinant human collagen albumen Nutrient, reinforce the collagen activity in skin, promote cell Proliferation migration, to promote the new old generation of skin histology It thanks, improves healing speed.
Further, the aquogel system further include: thickener, pH adjusting agent, amino acid, sugar and appropriate deionization Water.
Optionally, the thickener includes: xanthan gum, chitosan, hyaluronic acid, sodium carboxymethylcellulose, gelatin, poly- third One or more of olefin(e) acid sodium.Wherein, the concentration of each component is 1-50g/L in the thickener.
Optionally, the sugar includes one or more of glucose, fructose；Wherein the glucose and fructose is dense Degree is 1-50g/L.
Optionally, the amino acid includes but is not limited to: leucine, lysine, methionine, phenylalanine, serine, silk Propylhomoserin, alanine, day east gate propylhomoserin, cysteine, glutamic acid, arginine, proline, tryptophan, glutamic acid, glutamine, The concentration of at least one of tyrosine, glycine, valine, histidine, isoleucine etc. and the amino acid is 0.01-0.1g/L。
Optionally, the pH adjusting agent of this aquogel system can adjust acid-base balance by following two mode, to maintain The pH value of hydrogel is between 7.3-7.5.It is specific as follows:
A kind of optional embodiment as pH adjusting agent.
The pH adjusting agent includes: NaCl:110-150mmol/L；KCl:2.0-3.0mmol/L；Na2HPO4: 7- 13mmol/L；And KH2PO4: 1.8-2.4mmol/L.
Another optional embodiment as pH adjusting agent.
The pH adjusting agent includes: NaCl:110-150mmol/L；KCl:2-5mmol/L；NaH2PO4: 0.3-0.6mmol/ L；And Na2HPO4: 0.3-0.8mmol/L.
In conclusion this aquogel system by recombinant human collagen albumen and thickener, pH adjusting agent, amino acid, sugar and Deionized water mixing match forms hydrogel state, is coated at the surface of a wound, the reparation especially in severe trauma and large-area burns In the process, Wound dressing is gluey in water-setting, and the tissue of ingredient and skin is close, can not only play supplement protein, promotes The effect of skin cell proliferation migration, also has excellent water suction and water retention property, can keep cuticula moisture and fiber The integrality of structure, while can also play and adjust water, electrolyte and acid-base balance, good repairing environment is provided for the surface of a wound, Even has the function of hair follicle regeneration.
Embodiment 2
First weigh 110mmol NaCl, 2mmol KCl, 7mmol Na2HPO4 and 1.8mmol KH2PO4 is dissolved in 1000mL In deionized water, stirs to being completely dissolved, be configured to pH adjusting agent solution；Weigh again 0.01g amino acid, 1g glucose be added on It states in the pH adjusting agent solution of preparation；50g xanthan gum is added, is swollen pH adjusting agent solution sufficiently；Then 10g recombination is added Human collagen is stirred well to recombinant human collagen albumen and is completely dissolved and is uniformly mixed, forms the aquogel system, finally The gel dressing is made through high pressure steam sterilization.
Embodiment 3
First weigh 150mmol NaCl, 3mmol KCl, 13mmol Na2HPO4 and 2.4mmol KH2PO4 is dissolved in 1000mL In deionized water, stirs to being completely dissolved, be configured to pH adjusting agent solution；Weigh again 0.1g amino acid, 50g fructose be added it is above-mentioned In the pH adjusting agent solution of preparation；1g chitosan is added, is swollen pH adjusting agent solution sufficiently；Then 300g recombined human is added Collagen is stirred well to recombinant human collagen albumen and is completely dissolved and is uniformly mixed, forms the aquogel system, most pass through afterwards The gel dressing is made in high pressure steam sterilization.
Embodiment 4
First weigh 110mmol NaCl, 2mmol KCl, 0.3mmol Na2HPO4 and 0.3mmol Na2HPO4, it is dissolved in In 1000mL deionized water, stirs to being completely dissolved, be configured to pH adjusting agent solution；0.05g amino acid, 10g grape are weighed again Sugar is added in the pH adjusting agent solution of above-mentioned preparation；35g hyaluronic acid is added, is swollen pH adjusting agent solution sufficiently；Then 250g recombinant human collagen albumen is added, is stirred well to recombinant human collagen albumen and is completely dissolved and is uniformly mixed, form the water Most the gel dressing is made through high pressure steam sterilization afterwards in gel rubber system.
Embodiment 5
First weigh 150mmol NaCl, 5mmol KCl, 0.6mmol Na2HPO4 and 0.8mmol Na2HPO4, it is dissolved in In 1000mL deionized water, stirs to being completely dissolved, be configured to pH adjusting agent solution；0.08g amino acid, 35g grape are weighed again Sugar is added in the pH adjusting agent solution of above-mentioned preparation；15g Sodium Polyacrylate is added, is swollen pH adjusting agent solution sufficiently；So 100g recombinant human collagen albumen is added afterwards, is stirred well to recombinant human collagen albumen and is completely dissolved and is uniformly mixed, described in formation Most the gel dressing is made through high pressure steam sterilization afterwards in aquogel system.
Embodiment 6
The gel dressing of the application not only contains embodiment described in embodiment 2-5, and there are also other embodiments.Limit In length reason, on the basis of embodiment 1, the present embodiment 6 only enumerates main group of gel dressing in table 1, table 2 and table 3 Divide and content is no longer gone to live in the household of one's in-laws on getting married herein about its specific ingredient and implementation process referring to the discussion related in embodiment 2 of embodiment 1 It states.Wherein, the main component and content of gel dressing are listed in table 1, main group of the first pH adjusting agent is listed in table 2 Point and content, the main component and content of second of pH adjusting agent are listed in table 3.
The main component and content of 1 gel dressing of table
Embodiment Recombinant human collagen albumen Thickener Sugar Amino acid
Embodiment five 10 25 50 0.01
Embodiment six 40 5 1 0.04
Embodiment seven 150 10 20 0.06
Embodiment eight 200 45 10 0.09
Embodiment nine 240 1 5 0.1
Embodiment ten 300 50 15 0.1
Each component unit is g in table 1.
The main component and content of 2 the first pH adjusting agent of table
Embodiment NaCl KCl Na2HPO4 KH2PO4
Embodiment 11 110 3 8 2.2
Embodiment 12 115 3 11 2.4
Embodiment 13 125 2.8 13 2
Embodiment 14 135 2.4 10 1.8
Embodiment 15 150 2 9 2
Each component unit is mmol/L in table 2.
The main component and content of second of the pH adjusting agent of table 3
Embodiment NaCl KCl Na2HPO4 Na2HPO4
Embodiment 16 110 2 0.4 0.3
Embodiment 17 120 2.5 0.6 0.8
Embodiment 18 130 5 0.3 0.6
Embodiment 19 145 4 0.5 0.35
Embodiment 20 150 3 0.45 0.45
Each component unit is mmol/L in table 3.
Embodiment 7
On the basis of embodiment 6, the present embodiment 7 additionally provides a kind of preparation method of gel dressing, and the gel applies Material is suitable for sterile production and packaging.
Specifically, pH adjusting agent, thickener, amino acid, sugar and the deionized water in the gel dressing can be mixed It closes, recombinant human collagen albumen is then added, is most packed after high pressure steam sterilization afterwards.
Specific ingredient and implementation process about gel dressing are discussed referring to the correlation of embodiment 6, and details are not described herein again.
Embodiment 8
On the basis of embodiment 6, the present embodiment 8 additionally provides a kind of application method of gel dressing, comprising: by gel Dressing mulching forms it into hydrogel state on the surface of a wound；And semi-permeable membrane is closed in hydrogel surface mulching.
Optionally, the closing semi-permeable membrane is such as, but not limited to penetrating sterile closed film, aperture 100-200nm.
Specific ingredient and implementation process about gel dressing are discussed referring to the correlation of embodiment 6, and details are not described herein again.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention Property range is not limited to the contents of the specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.

Claims (10)

1. a kind of gel dressing characterized by comprising
Aquogel system containing recombinant human collagen albumen；
The aquogel system is suitable for forming hydrogel state on surface of a wound surface.
2. gel dressing according to claim 1, which is characterized in that
The concentration of the recombinant human collagen albumen is 10-300g/L.
3. gel dressing according to claim 1, which is characterized in that
The aquogel system further include: thickener, pH adjusting agent, amino acid, sugar and appropriate amount of deionized water.
4. gel dressing according to claim 3, which is characterized in that
The thickener include: xanthan gum, chitosan, hyaluronic acid, sodium carboxymethylcellulose, gelatin, in Sodium Polyacrylate It is one or more of.
5. gel dressing according to claim 4, which is characterized in that
The concentration of each component is 1-50g/L in the thickener.
6. gel dressing according to claim 3, which is characterized in that
The pH adjusting agent includes:
NaCl:110-150mmol/L；
KCl:2.0-3.0mmol/L；
Na2HPO4: 7-13mmol/L；And
KH2PO4: 1.8-2.4mmol/L.
7. gel dressing according to claim 3, which is characterized in that
The pH adjusting agent includes:
NaCl:110-150mmol/L；
KCl:2-5mmol/L；
NaH2PO4: 0.3-0.6mmol/L；And
Na2HPO4: 0.3-0.8mmol/L.
8. gel dressing according to claim 3, which is characterized in that
The sugar includes one or more of glucose, fructose；Wherein
The concentration of the glucose and fructose is 1-50g/L.
9. a kind of application method of gel dressing characterized by comprising
Gel dressing mulching is formed it into hydrogel state on the surface of a wound；And
Semi-permeable membrane is closed in hydrogel surface mulching.
10. a kind of preparation method of gel dressing, which is characterized in that
The gel dressing is suitable for sterile production and packaging.
CN201910052370.2A 2019-01-21 2019-01-21 Promote gel dressing of cell Proliferation migration and preparation method thereof, application method Pending CN109529104A (en)

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Cited By (5)

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CN110665070A (en) * 2019-10-13 2020-01-10 四川大学 Medical coating with hydrophilic lubricating surface and preparation method thereof
CN111529692A (en) * 2020-04-30 2020-08-14 刘雨升 Stable collagen system and preparation method and application thereof
CN114832140A (en) * 2022-05-06 2022-08-02 江苏益仁堂生物科技有限公司 Medical skin repair dressing formula
CN115137868A (en) * 2021-03-30 2022-10-04 西安德诺海思医疗科技有限公司 Recombinant collagen dressing and preparation method thereof
CN116173291A (en) * 2023-03-08 2023-05-30 重庆医科大学附属第二医院 Chitosan recombinant humanized collagen gel and preparation method and application thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110665070A (en) * 2019-10-13 2020-01-10 四川大学 Medical coating with hydrophilic lubricating surface and preparation method thereof
CN111529692A (en) * 2020-04-30 2020-08-14 刘雨升 Stable collagen system and preparation method and application thereof
CN115137868A (en) * 2021-03-30 2022-10-04 西安德诺海思医疗科技有限公司 Recombinant collagen dressing and preparation method thereof
CN115137868B (en) * 2021-03-30 2023-10-20 西安德诺海思医疗科技有限公司 Recombinant collagen dressing and preparation method thereof
CN114832140A (en) * 2022-05-06 2022-08-02 江苏益仁堂生物科技有限公司 Medical skin repair dressing formula
CN116173291A (en) * 2023-03-08 2023-05-30 重庆医科大学附属第二医院 Chitosan recombinant humanized collagen gel and preparation method and application thereof

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