CN109528162A - A kind of toy pain-measuring equipment and its application - Google Patents
A kind of toy pain-measuring equipment and its application Download PDFInfo
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- CN109528162A CN109528162A CN201811340595.XA CN201811340595A CN109528162A CN 109528162 A CN109528162 A CN 109528162A CN 201811340595 A CN201811340595 A CN 201811340595A CN 109528162 A CN109528162 A CN 109528162A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
- A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
- A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
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- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of toy pain-measuring equipment and its application, above equipment includes separating test platform, lower part rotating device and liftable support；Separation test platform in the present invention includes animal buffer area, animal machinery pain measurement region and animal heat radiation pain measurement region from the inside to the outside, and animal machinery pain measurement region and animal heat radiation pain measurement region have multiple compartments；It is provided with the third partition that can be extracted and the animal machinery pain measurement region between the animal buffer area and animal machinery pain measurement region and animal heat radiation pain measurement region is provided with the 4th partition that can be extracted；The present invention surveys in pain in experimental animal to distinguish desired height when distinct methods survey pain with oscilaltion, can 360 ° rotate and be fixed on tester and need the position of Orientation observation convenient for operation；Convenient for do not influence animal adapt to ambient conditions under two kinds of survey pain modes switch at random；Convenient for clearing up platform in time to guarantee to survey pain and go on smoothly；Ensure that data are true and reliable, tester facilitates operation.
Description
Technical field
The present invention relates to preclinical medicine scientific research fields, and in particular to a kind of toy pain-measuring equipment and its application.
Background technique
Pain is the impression in a kind of undesirable feeling and mood, with substantial or potential tissue damage,
It is a kind of subjective feeling." threshold of pain " refers to the minimum values for causing pain, in the base mechanisms research of pain, usually transports
Body is measured to the sensibility of pain with the detection of the threshold of pain.The pain research of experimental animal is primarily upon the survey of two kinds of threshold of pains
Fixed: one is the temperature sensation threshold of pains, and detecting capital equipment is theral radiation instrument, and the equipment is infrared or visible using some strength
Light beam irradiates the vola skin of rodent, measure from start to be irradiated to animal because of pain and occur lift foot hide movement when
Between, the referred to as sufficient incubation period (Thermal Withdrawal latency, TWL) of pyrocondensation, unit: s.Another kind is that mechanical pressure is felt
The threshold of pain, abbreviation tenderness threshold, the equipment that detection mechanical pressure is felt are electronics pain threshold detector von Frey, which has thin and long spy
Needle, equipment tip can apply pressure, equipment to the large and small mouse rear solid end bottom surface above the strainer for having suitable size mesh from below
The pressure value of record is subject to metapedes and occurs paw withdrawal movement because of pain, which is known as mechanicalness paw withdrawal threshold (Mechanical
Withdrawal Threshold, MWT), unit: g.
Surveying pain at present need to carry out in relatively independent and very quiet environment.Calorimetric pain generally uses rectangle glass
Pallet frame, and survey tenderness threshold and then need using meshed rectangle rack, the survey threshold of pain in this way will use two kinds of racks, often
It needs to carry out calorimetric pain in practical application simultaneously and surveys the test of tenderness threshold, so that experimentation needs on the two racks back and forth
Position is converted, causes animal that can not comparatively fast adapt to environment and enters trystate, inconvenient to use, detection efficiency is low；In addition, experiment
Because of pollution of the animal excrements to test platform table top in application process, survey can be just normally carried out after needing frequent progress to clear up
Examination, also results in very big interference to Animal adaptability；Tester need to relatively long distance translates back and forth in existing test platform, is easier to send out
Raw damage, tester are also required to that larger displacement occurs therewith, the larger direct interference testing result of noise.
Summary of the invention
The purpose of the invention is to overcome the above problem of the existing technology, provide a kind of toy pain-measuring equipment and
It is applied, which has well solved animal on two kinds of racks to turn round the problem of changing；And completely solve platform in test
Problem and interference problem are cleared up in face.
To achieve the goals above, in the embodiment on basis, one aspect of the present invention, which provides a kind of toy, to be surveyed pain and sets
It is standby, comprising:
Separate test platform, the separation test platform includes animal buffer area, animal machinery pain measurement region from the inside to the outside
And animal heat radiation pain measurement region；The animal machinery pain measurement region is internally provided with an at least first partition, is divided into
At least two first compartments；The animal heat radiation pain measurement region is internally provided with an at least second partition, be divided into
Few two second compartments；It is provided with the third partition that can be extracted between the animal buffer area and animal machinery pain measurement region, with
And the animal machinery pain measurement region and animal heat radiation pain measurement region are provided with the 4th partition that can be extracted；Animal buffer area,
Animal machinery pain measurement region and animal heat radiation pain measurement region are each provided with the cover board at top and the bottom plate of bottom surface；
Lower part rotating device, the lower part rotating device include rotary shaft and enclose the rotating body rotated about；The rotation
Turn to connect the separation test platform above ontology；
Liftable support, including height-adjustable strut and rack body connected to it, the lower part rotating dress
The rotary shaft one end set is connect with the separation test platform, and the other end connects the strut, and pain threshold detector is arranged in the bracket
On ontology.
In a preferred embodiment, the strut is sleeved on the outer surface of rotary shaft, along the rotary shaft
Length direction sliding.
In a preferred embodiment, there is the first stop device between the strut and rotary shaft；
Preferably, first stop device is the scotch being arranged on the outer wall of rotary shaft one end.
In a preferred embodiment, there is the second stop device between the rotary shaft and rotating body；
Preferably, second stop device is that be arranged in be the scotch being arranged on the outer wall of rotary shaft one end.
In a preferred embodiment, the animal buffer area, animal machinery pain measurement region and animal heat radiation
Pain measurement region is annular.
In a preferred embodiment, the bottom plate of the animal buffer area and animal machinery pain measurement region is grid
Plate, cover board are provided with air hole.
In a preferred embodiment, the bottom plate of the animal buffer area and animal machinery pain measurement region is stainless
Steel steel wire, cover board are band air hole transparent panel.
In a preferred embodiment, the bottom plate of the animal heat radiation pain measurement region is thin glass plate, lid
Plate is band air hole transparent panel.
In a preferred embodiment, the first partition and second partition are impermeable isotropic disk, the third partition
It is transparent panel with the 4th partition.
Second aspect of the present invention provides the application of above-mentioned toy pain-measuring equipment, be applied to toy radiant heat pain and
The detection of mechanical pressure pain.
Through the above technical solutions, the separation test platform in the present invention includes animal buffer area, animal machine from the inside to the outside
Tool pain measurement region and animal heat radiation pain measurement region, and animal machinery pain measurement region and animal heat radiation pain measurement region are with multiple
Compartment；The third partition that can be extracted and the animal are provided between the animal buffer area and animal machinery pain measurement region
Mechanical pain measurement region and animal heat radiation pain measurement region are provided with the 4th partition that can be extracted；It is convenient for not influencing animal as a result,
Two kinds of survey pain modes under ambient conditions are adapted to switch at random；Convenient for clearing up platform in time to guarantee to survey pain and go on smoothly；Data are true
Real reliable, tester facilitates operation, and equipment loss is small；Lower part rotating device of the present invention, can 360 ° rotate smoothly and be fixed on survey
Examination person needs the position of Orientation observation convenient for operation；In addition, liftable support, convenient for experimental animal survey in pain it is adjustable simultaneously
It is fixed on different survey pain mode desired heights.
Detailed description of the invention
Fig. 1 is the toy pain-measuring equipment structural schematic diagram that embodiment of the present invention provides；
Description of symbols
1- separation test platform, the lower part 2- rotating device, 3- liftable support, 4- pain threshold detector, 1.1- animal buffer area,
1.2- animal machinery pain measurement region, 1.3- animal heat radiation pain measurement region, 2.1- rotary shaft, 2.2- rotating body, 3.1- strut,
3.2- rack body；1.11,1.23- waffle slab, 1.12,1.24,1.34- cover board, 1.21- first partition, 1.22- third every
Plate, 1.31- second partition, the 4th partition of 1.32-, 1.33- thin glass plate.
Specific embodiment
In order to better understand the above technical scheme, being done below by specific embodiment to technical scheme detailed
Explanation, it should be understood that the specific features in the embodiment of the present application and embodiment be to technical scheme specifically
It is bright, rather than the restriction to technical scheme, in the absence of conflict, the skill in the embodiment of the present application and embodiment
Art feature can be combined with each other.It should be understood that term "and/or" used herein above includes listed by one of them or more
Any and all combinations of associated item out.
The present invention provides a kind of toy pain-measuring equipment, comprising:
Separate test platform, the separation test platform includes animal buffer area, animal machinery pain measurement region from the inside to the outside
And animal heat radiation pain measurement region；The animal machinery pain measurement region is internally provided with an at least first partition, is divided into
At least two first compartments；The animal heat radiation pain measurement region is internally provided with an at least second partition, be divided into
Few two second compartments；It is provided with the third partition that can be extracted between the animal buffer area and animal machinery pain measurement region, with
And the animal machinery pain measurement region and animal heat radiation pain measurement region are provided with the 4th partition that can be extracted；Animal buffer area,
Animal machinery pain measurement region and animal heat radiation pain measurement region are each provided with the cover board at top and the bottom plate of bottom surface；
Lower part rotating device, the lower part rotating device include rotary shaft and enclose the rotating body rotated about；The rotation
Turn to connect the separation test platform above ontology；
Liftable support, including height-adjustable strut and rack body connected to it, the lower part rotating dress
The rotary shaft one end set is connect with the separation test platform, and the other end connects the strut, and pain threshold detector is arranged in the bracket
On ontology.
Wherein, above-mentioned separation test platform may be configured as shellring shape movable partition platform, preferably stainless steel, glass,
Organic glass mixed materials structure cylindrical body.Structure innermost layer is the roundworm buffer area not separated, and bottom surface is waffle slab, top
Lid is oolemma air hole cover board；Structure middle layer is to separate annular animal machinery pain measurement region, is equally divided into multiple compartments, every
Room is separated by impermeable isotropic disk.Bottom surface is waffle slab, and top cover is band air hole transparent cover plate, each compartment between the area and buffer area
Equipped with drawing out type lamina of septum pellucidum；Structure outermost layer is to separate annular animal heat radiation pain measurement region, is equally divided into multiple compartments,
Compartment is separated by impermeable isotropic disk.Bottom surface is the thin plate, and top cover is band air hole transparent cover plate, every between the area and the machinery area Ce Tong
A compartment is equipped with drawing out type lamina of septum pellucidum.Turn between buffer area, heat radiation pain and mechanical pain measurement region when animal testing
Lamina of septum pellucidum need to be only taken out out when changing to carry out, very convenient.The material of above-mentioned cover board, waffle slab, partition etc. is with no restriction, excellent
It is selected as organic glass, glass or stainless steel material etc..
Moreover, shellring shape movable partition platform and the mute lower part rotating device reasonable combination braked exist in the present invention
Together, can 360 ° rotate smoothly and be fixed on tester and need the position of Orientation observation convenient for operation.The rotary shaft and rotation
There is the second stop device between ontology, is rotated smoothly for rotating body and stop on demand；Preferably, the second stop dress
It is set to the scotch being arranged in be arranged on the outer wall of rotary shaft one end.
In addition, also liftable support, including height-adjustable branch can be arranged below test platform separating in the present invention
Bar and rack body connected to it；Preferably, the strut is sleeved on the outer surface of rotary shaft, along the rotary shaft
Length direction slides, and may also set up scale on strut convenient for adjusting on demand, to survey adjustable in pain rise in experimental animal
Descending branch frame is simultaneously fixed on different survey pain mode desired heights.Further, there is the first stop dress between the strut and rotary shaft
It sets；Preferably, first stop device is the scotch being arranged on the outer wall of rotary shaft one end.
The installation site of pain threshold detector device, which may be provided at, to be separated below test platform, is arranged on demand, such as setting can rise
On descending branch frame.
Thus, the present invention is a kind of rotary type heat, mechanical dual-purpose toy pain-measuring equipment, is suitable for rat, mouse, globefish
The rodents such as mouse, movable partition platform can choose different sizes to be suitble to the experimental animal of Different Individual size.
Below with reference to the drawings and specific embodiments, the present invention will be described in detail.
As shown in Figure 1, toy pain-measuring equipment of the embodiment of the present invention, comprising: separate test platform 1, lower part rotating device 2
And liftable support 3, above-mentioned lower part rotating device include rotary shaft 2.1 and enclose the rotating body 2.2 rotated about；Above-mentioned rotation
Turn to connect the separation test platform 1 above ontology 2.2；Above-mentioned liftable support 3 include height-adjustable strut 3.1 and
Rack body 3.2 connected to it, 2.1 one end of rotary shaft of the lower part rotating device are connect with the separation test platform 1,
The other end connects above-mentioned strut 3.2, and pain threshold detector 4 is arranged on the rack body 3.2.
Above-mentioned separation test platform is shellring shape structure, is stainless steel, glass, organic glass mixed materials structure circle
Cylinder, bottom surface overall diameter 50cm, high 25cm.Structure innermost layer is not separate roundworm buffer area 1.1, diameter 20cm, bottom surface
For stainless steel steel wire panel 1.11 (grid aperture 0.4*0.4mm), top cover is oolemma air hole organic glass cover board 1.12；
Structure middle layer is to separate annular animal machinery pain measurement region 1.2, diameter 15cm, is equally divided into 6 first compartments, is spaced by not
The first partition 1.21 of transparent organic glass material is separated.Bottom surface is (the grid aperture 0.4* of stainless steel steel wire panel 1.23
0.4mm), top cover is band air hole transparent organic glass cover board 1.24, and each compartment is equipped with and can extract between the area and buffer area
The third partition 1.22 of formula transparent organic glass material；Structure outermost layer is to separate annular animal heat radiation pain measurement region 1.3, directly
Diameter 15cm, is equally divided into 6 second compartments, and interval is separated by the second partition 1.31 of opaque organic glass material.Bottom surface is
Glass material the thin plate 1.33 (thickness 1mm), top cover are band air hole transparent organic glass cover board 1.34, the area and mechanical survey pain
Each compartment is equipped with the 4th partition 1.32 of drawing out type transparent organic glass material between area.When animal testing buffer area,
Transparent organic glass partition, which need to only be taken out out, when converting between heat radiation pain and mechanical pain measurement region to carry out, very convenient.
The present embodiment pain-measuring equipment is used for mouse and surveys mechanical pain and heat radiation pain, is confirmed by practical application, well
Solve the problems, such as that animal is changed on two kinds of racks to turn round；It is fully solved table top cleaning problem and interference problem in test；It surveys
Pain instrument does not need the larger translation back and forth in existing test platform, is not susceptible to damage, tester do not need to occur therewith yet compared with
Big displacement, noise is smaller, and tester's operation is easily convenient, meets very much animal welfare, testing result is true and reliable, great popularization
Value.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (10)
1. a kind of toy pain-measuring equipment, it is characterised in that: include:
Separate test platform, the separation test platform includes animal buffer area, animal machinery pain measurement region and moves from the inside to the outside
Object heat radiation pain measurement region；The animal machinery pain measurement region is internally provided with an at least first partition, is divided at least
Two first compartments；The animal heat radiation pain measurement region is internally provided with an at least second partition, is divided at least two
A second compartment；The third partition that can be extracted, Yi Jisuo are provided between the animal buffer area and animal machinery pain measurement region
It states animal machinery pain measurement region and animal heat radiation pain measurement region is provided with the 4th partition that can be extracted；Animal buffer area, animal
Mechanical pain measurement region and animal heat radiation pain measurement region are each provided with the cover board at top and the bottom plate of bottom surface；
Lower part rotating device, the lower part rotating device include rotary shaft and enclose the rotating body rotated about；The rotation is originally
The separation test platform is connected above body；
Liftable support, including height-adjustable strut and rack body connected to it, the lower part rotating device
Rotary shaft one end is connect with the separation test platform, and the other end connects the strut, and pain threshold detector is arranged in the rack body
On.
2. pain-measuring equipment according to claim 1, which is characterized in that the strut is sleeved on the outer surface of rotary shaft,
It is slided along the length direction of the rotary shaft.
3. pain-measuring equipment according to claim 2, which is characterized in that have the first stop between the strut and rotary shaft
Device；
Preferably, first stop device is the scotch being arranged on the outer wall of rotary shaft one end.
4. pain-measuring equipment according to claim 1, which is characterized in that have second between the rotary shaft and rotating body
Stop device；
Preferably, second stop device is that be arranged in be the scotch being arranged on the outer wall of rotary shaft one end.
5. pain-measuring equipment according to claim 1, which is characterized in that the animal buffer area, the mechanical pain of animal measure
Area and animal heat radiation pain measurement region are annular.
6. pain-measuring equipment according to claim 1, which is characterized in that the animal buffer area and the mechanical pain of animal measure
The bottom plate in area is waffle slab, and cover board is provided with air hole.
7. pain-measuring equipment according to claim 6, which is characterized in that the animal buffer area and the mechanical pain of animal measure
The bottom plate in area is stainless steel steel wire, and cover board is band air hole transparent panel.
8. pain-measuring equipment according to claim 1, which is characterized in that the bottom plate of the animal heat radiation pain measurement region is
Thin glass plate, cover board are band air hole transparent panel.
9. pain-measuring equipment according to claim 1, which is characterized in that the first partition and second partition are opaque
Plate, the third partition and the 4th partition are transparent panel.
10. the application of toy pain-measuring equipment as described in claim any one of 1-9, it is characterised in that: be applied to petty action
The detection of object radiant heat pain and mechanical pressure pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811340595.XA CN109528162A (en) | 2018-11-12 | 2018-11-12 | A kind of toy pain-measuring equipment and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811340595.XA CN109528162A (en) | 2018-11-12 | 2018-11-12 | A kind of toy pain-measuring equipment and its application |
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| Publication Number | Publication Date |
|---|---|
| CN109528162A true CN109528162A (en) | 2019-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811340595.XA Pending CN109528162A (en) | 2018-11-12 | 2018-11-12 | A kind of toy pain-measuring equipment and its application |
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Application publication date: 20190329 |
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