CN109511785A - A kind of multi-vitamins pellet for animals and preparation method thereof - Google Patents

A kind of multi-vitamins pellet for animals and preparation method thereof Download PDF

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Publication number
CN109511785A
CN109511785A CN201811587316.XA CN201811587316A CN109511785A CN 109511785 A CN109511785 A CN 109511785A CN 201811587316 A CN201811587316 A CN 201811587316A CN 109511785 A CN109511785 A CN 109511785A
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parts
vitamin
vitamins
component
weight
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李竹
谌京梅
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Leshan Baierte Bioengineering Partnership LP
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Leshan Recondex Animal Health Care Pharmaceutical Co Ltd
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Priority to CN201811587316.XA priority Critical patent/CN109511785A/en
Publication of CN109511785A publication Critical patent/CN109511785A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/174Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K40/00Shaping or working-up of animal feeding-stuffs
    • A23K40/30Shaping or working-up of animal feeding-stuffs by encapsulating; by coating

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of multi-vitamins pellet for animals and preparation method thereof, a kind of multi-vitamins pellet for animals, including multi-vitamins, compound amino acid, compound Chinese medicine, coating agent, coating auxiliary material;A kind of preparation method of multi-vitamins pellet for animals, comprising the following steps: prepare multi-vitamins;Prepare compound amino acid;Compound Chinese medicine is prepared, compound Chinese medicine is prepared into pulvis;Compound cellulose capsule core is prepared using compound cellulose, compound amino acid, compound Chinese medicine as raw material;Coating solution is prepared using coating agent, coating auxiliary material as raw material, compound cellulose capsule core is placed in seed-coating machine, coating solution is injected into seed-coating machine, compound cellulose capsule core is coated, multi-vitamins pellet is obtained after drying.The nutritive value of pellet of the present invention is high, and preparation method of the present invention is simple, is coated with by packaging technique to pellet, improves the stability of pellet.

Description

A kind of multi-vitamins pellet for animals and preparation method thereof
Technical field
The present invention relates to a kind of multi-vitamins, and in particular to a kind of multi-vitamins pellet for animals and preparation method thereof.
Background technique
Vitamin is that humans and animals are to maintain normal physiological function and must obtain from food a kind of micro organic Substance plays an important role in growth in humans, metabolism, growth course.During the animal feedings such as pig, ox, sheep, growth The difference of phase requires supplementation with corresponding vitamin, to improve the health status of animal;Digestive system is effectively improved, is quickly mended Filled with beneficial bacteria, inhibits disinfect pathogen proliferation, adjust the intestinal flora ecological balance;Feeding antibiotic is reduced or substituted, drug resistance is reduced Property;Enhance animal non-specific immunity, reduces the advantages that 60% or more disease incidence waits.
The multi-vitamins of Vehicles Collected from Market are various in style, and quality is irregular, most of all only by simple several dimensions Raw element mixes, and not comprehensive nutrition, stability is bad, and bioavilability is not high, and effect is single, it is difficult to it is raw to meet kind of fowl comprehensively Needed for long development, the nutrition of production process.
Summary of the invention
The technical problem to be solved by the present invention is to the multi-vitamins not comprehensive nutritions of Vehicles Collected from Market, and stability is bad, Bioavilability is not high, and effect is single, it is difficult to meet needed for kind of a fowl growth and development, the nutrition of production process comprehensively, it is therefore intended that A kind of tight device of work piece positioning is provided, the multi-vitamins not comprehensive nutrition of Vehicles Collected from Market is solved, stability is bad, biology benefit Expenditure is not high, and effect is single, it is difficult to problem needed for meeting kind of a fowl growth and development, the nutrition of production process comprehensively.
The present invention is achieved through the following technical solutions:
A kind of multi-vitamins pellet for animals, including multi-vitamins, compound amino acid, compound Chinese medicine, coating agent, coating Auxiliary material;
The multi-vitamins include the component of following parts by weight: 10-30 parts of vitamin As, 10-30 parts of vitamin B1s, 10-20 parts of vitamin Cs, 8-15 parts of vitamin Ds, 10-30 parts of vitamin Bs 6,10-30 parts of vitamin Bs 12,8-15 parts of vitamins E, 8-15 parts of vitamin Ks 3,3-10 parts of folic acid, 10-15 parts of biotins;
The compound amino acid includes the component of following parts by weight: 3-8 parts of glycine, 2-10 parts of alanine, 1-6 parts of figured silk fabrics Propylhomoserin, 4-10 part leucine, 2-6 parts of aspartic acids, 1-5 parts of R-genes, 1-6 parts of lysine hydrochlorides, 3-6 parts of phenylpropyl alcohol ammonia Acid, 3-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 20-30 portions of honeysuckles, 10-20 parts of radix bupleuri, 10-15 parts Folium isatidis, 8-12 part rice sprout, 10-15 parts of pine needle meals, 10-20 portions of rabdosia lophanthides, 8-15 parts of apple pomaces, 10-20 parts of cassia seeds, 5-15 Part Radix Astragali, 10-20 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-15 parts of methacrylic acid/ethyl acrylate copolymerization Object, 20-40 part hydroxypropyl methyl cellulose, 10-30 parts of Arabic gums;
It is described coating auxiliary material include following parts by weight component: 2-8 parts of plasticizer, 1-5 parts of pore-foaming agents, 0.5-3 parts disappear Infusion.
Three kinds of compound mutual compatible uses of component, effectively raise the nutritive value of multi-vitamins in the present invention, And then improve the utilization rate and absorptivity of compound cellulose;The present invention prepares coating solution with coating agent, coating auxiliary material, to compound Cellulose is coated with, and can be improved the stability of compound cellulose;The present invention joined compound Chinese medicine in compound cellulose, Compound Chinese medicine can increase the nutritive value of multi-vitamins, additionally it is possible to which enhancing uses disease-resistant, the immunocompetence of object.The present invention The cellulase type in compound cellulose is increased, and compound cellulose is prepared into conjunction with compound amino acid, compound Chinese medicine Pellet improves the nutritive value of existing compound cellulose;The present invention is coated with compound cellulose pellet using coating solution, Improve the stability of compound cellulose.
A kind of multi-vitamins pellet for animals, including multi-vitamins, compound amino acid, compound Chinese medicine, coating Agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 20-30 parts of vitamin As, 20-30 parts of vitamin B1s, 10-15 parts of vitamin Cs, 10-15 parts of vitamin Ds, 15-25 parts of vitamin Bs 6,20-30 parts of vitamin Bs 12,8-12 parts of vitamins E, 8-12 parts of vitamin Ks 3,6-10 parts of folic acid, 10-13 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-8 parts of glycine, 2-5 parts of alanine, 1-3 parts of figured silk fabrics Propylhomoserin, 6-10 part leucine, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 4-6 parts of phenylpropyl alcohol ammonia Acid, 5-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 25-30 portions of honeysuckles, 15-20 parts of radix bupleuri, 10-12 parts Folium isatidis, 8-10 part rice sprout, 10-13 parts of pine needle meals, 15-20 portions of rabdosia lophanthides, 10-15 parts of apple pomaces, 15-20 parts of cassia seeds, 10- 15 parts of Radix Astragalis, 10-15 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-13 parts of methacrylic acid/ethyl acrylate copolymerization Object, 20-30 part hydroxypropyl methyl cellulose, 20-30 parts of Arabic gums;
It is described coating auxiliary material include following parts by weight component: 2-5 parts of plasticizer, 1-3 parts of pore-foaming agents, 0.5-1 parts disappear Infusion.
The preferred ratio range of each component of the present invention.
A kind of multi-vitamins pellet for animals, including multi-vitamins, compound amino acid, compound Chinese medicine, coating Agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 25-30 parts of vitamin As, 25-30 parts of vitamin B1s, 12-15 parts of vitamin Cs, 12-15 parts of vitamin Ds, 20-25 parts of vitamin Bs 6,25-30 parts of vitamin Bs 12,10-12 parts of dimension lifes Plain E, 10-12 part of vitamin K 3,6-8 parts of folic acid, 10-12 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-7 parts of glycine, 3-5 parts of alanine, 2-3 parts of figured silk fabrics Propylhomoserin, 6-8 part leucine, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 5-6 parts of phenylalanines, 6-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 28-30 portions of honeysuckles, 15-18 parts of radix bupleuri, 11-12 parts Folium isatidis, 8-10 part rice sprout, 10-12 parts of pine needle meals, 18-20 portions of rabdosia lophanthides, 10-12 parts of apple pomaces, 15-18 parts of cassia seeds, 12- 15 parts of Radix Astragalis, 12-15 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-12 parts of methacrylic acid/ethyl acrylate copolymerization Object, 25-30 part hydroxypropyl methyl cellulose, 25-30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2-3 parts of plasticizer, 1-2 parts of pore-foaming agents, 0.5-0.8 parts Defoaming agent.
The further preferred ratio range of each component of the present invention.
A kind of multi-vitamins pellet for animals, including multi-vitamins, compound amino acid, compound Chinese medicine, coating Agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 30 parts of vitamin As, 30 parts of vitamin B1s, 15 parts of dimensions Raw element C, 15 parts of vitamin Ds, 23 parts of 6,30 parts of vitamin B, 12,11 parts of vitamin B vitamin Es, 11 parts of Vitamin K3s, 8 parts of leaves Acid, 11.5 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6.5 parts of glycine, 4 parts of alanine, 3 parts of valines, 8 parts of leucines, 4 parts of aspartic acids, 5 parts of R-genes, 2.5 parts of lysine hydrochlorides, 6 parts of phenylalanines, 8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 30 portions of honeysuckles, 16 parts of radix bupleuri, 12 portions of folium isatidis, 9 parts Rice sprout, 12 parts of pine needle meals, 19 portions of rabdosia lophanthides, 12 parts of apple pomaces, 18 parts of cassia seeds, 14 parts of Radix Astragalis, 13.5 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 12 parts of methacrylic acid/ethyl acrylate copolymers, 28 Part hydroxypropyl methyl cellulose, 30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2.5 parts of plasticizer, 2 parts of pore-foaming agents, 0.8 part of defoaming agent.
The comprehensive performance of combination product of the present invention, the preferably proportion of each component.
A kind of multi-vitamins pellet for animals, further include the component of following parts by weight: the plasticizer is lemon Lemon triethylenetetraminehexaacetic acid ester, the pore-foaming agent are polyethylene glycol, and defoaming agent is the fatty acid ester compounded object of higher alcohols.
A kind of preparation method of the multi-vitamins pellet for animals, comprising the following steps:
S1, multi-vitamins are prepared;
S2, compound amino acid is prepared;
S3, compound Chinese medicine is prepared, compound Chinese medicine is prepared into pulvis;
S4, compound cellulose capsule core is prepared using compound cellulose, compound amino acid, compound Chinese medicine as raw material;
S5, coating solution is prepared using coating agent, coating auxiliary material as raw material, compound cellulose capsule core is placed on seed-coating machine In, coating solution being injected into seed-coating machine, compound cellulose capsule core being coated, multi-vitamins pellet is obtained after drying.
Preparation method of the present invention is simple, is coated with by packaging technique to pellet, improves the stability of pellet.
Drying temperature is 40-60 DEG C in step S5.The present invention controls the drying temperature after coating of pellets, avoids temperature mistake Nutritive value that is high and destroying pellet.
The partial size of compound cellulose capsule core is 10-60 mesh.
Compared with prior art, the present invention having the following advantages and benefits:
1, three kinds of compound mutual compatible uses of component in a kind of multi-vitamins pellet for animals of the present invention, it is effective to improve The nutritive value of multi-vitamins, and then improve the utilization rate and absorptivity of compound cellulose;
2, a kind of multi-vitamins pellet for animals of the present invention is coated with compound cellulose pellet using coating solution, improves The stability of compound cellulose;
3, a kind of preparation method preparation process of multi-vitamins pellet for animals of the present invention is simple, by packaging technique to micro- Ball is coated with, and the stability of pellet is improved.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below with reference to embodiment, the present invention is made Further to be described in detail, exemplary embodiment of the invention and its explanation for explaining only the invention, are not intended as to this The restriction of invention.
Embodiment 1
A kind of multi-vitamins pellet for animals of the present invention, including multi-vitamins, compound amino acid, compound Chinese medicine, coating Agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 10-30 parts of vitamin As, 10-30 parts of vitamin B1s, 10-20 parts of vitamin Cs, 8-15 parts of vitamin Ds, 10-30 parts of vitamin Bs 6,10-30 parts of vitamin Bs 12,8-15 parts of vitamins E, 8-15 parts of vitamin Ks 3,3-10 parts of folic acid, 10-15 parts of biotins;
The compound amino acid includes the component of following parts by weight: 3-8 parts of glycine, 2-10 parts of alanine, 1-6 parts of figured silk fabrics Propylhomoserin, 4-10 part leucine, 2-6 parts of aspartic acids, 1-5 parts of R-genes, 1-6 parts of lysine hydrochlorides, 3-6 parts of phenylpropyl alcohol ammonia Acid, 3-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 20-30 portions of honeysuckles, 10-20 parts of radix bupleuri, 10-15 parts Folium isatidis, 8-12 part rice sprout, 10-15 parts of pine needle meals, 10-20 portions of rabdosia lophanthides, 8-15 parts of apple pomaces, 10-20 parts of cassia seeds, 5-15 Part Radix Astragali, 10-20 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-15 parts of methacrylic acid/ethyl acrylate copolymerization Object, 20-40 part hydroxypropyl methyl cellulose, 10-30 parts of Arabic gums;
It is described coating auxiliary material include following parts by weight component: 2-8 parts of plasticizer, 1-5 parts of pore-foaming agents, 0.5-3 parts disappear Infusion.
A kind of multi-vitamins pellet for animals, further include the component of following parts by weight: the plasticizer is lemon Lemon triethylenetetraminehexaacetic acid ester, the pore-foaming agent are polyethylene glycol, and defoaming agent is the fatty acid ester compounded object of higher alcohols.
Three kinds of compound mutual compatible uses of component, effectively raise the nutritive value of multi-vitamins in the present invention, And then improve the utilization rate and absorptivity of compound cellulose;The present invention prepares coating solution with coating agent, coating auxiliary material, to compound Cellulose is coated with, and can be improved the stability of compound cellulose;The present invention joined compound Chinese medicine in compound cellulose, Compound Chinese medicine can increase the nutritive value of multi-vitamins, additionally it is possible to which enhancing uses disease-resistant, the immunocompetence of object.The present invention The cellulase type in compound cellulose is increased, and compound cellulose is prepared into conjunction with compound amino acid, compound Chinese medicine Pellet improves the nutritive value of existing compound cellulose;The present invention is coated with compound cellulose pellet using coating solution, Improve the stability of compound cellulose.
Embodiment 2
Based on embodiment 1, a kind of multi-vitamins pellet for animals, including it is multi-vitamins, compound amino acid, multiple Close Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 20-30 parts of vitamin As, 20-30 parts of vitamin B1s, 10-15 parts of vitamin Cs, 10-15 parts of vitamin Ds, 15-25 parts of vitamin Bs 6,20-30 parts of vitamin Bs 12,8-12 parts of vitamins E, 8-12 parts of vitamin Ks 3,6-10 parts of folic acid, 10-13 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-8 parts of glycine, 2-5 parts of alanine, 1-3 parts of figured silk fabrics Propylhomoserin, 6-10 part leucine, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 4-6 parts of phenylpropyl alcohol ammonia Acid, 5-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 25-30 portions of honeysuckles, 15-20 parts of radix bupleuri, 10-12 parts Folium isatidis, 8-10 part rice sprout, 10-13 parts of pine needle meals, 15-20 portions of rabdosia lophanthides, 10-15 parts of apple pomaces, 15-20 parts of cassia seeds, 10- 15 parts of Radix Astragalis, 10-15 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-13 parts of methacrylic acid/ethyl acrylate copolymerization Object, 20-30 part hydroxypropyl methyl cellulose, 20-30 parts of Arabic gums;
It is described coating auxiliary material include following parts by weight component: 2-5 parts of plasticizer, 1-3 parts of pore-foaming agents, 0.5-1 parts disappear Infusion.
The preferred ratio range of each component of the present invention.
Embodiment 3
Based on the above embodiment, a kind of multi-vitamins pellet for animals, including multi-vitamins, compounded amino Acid, compound Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 25-30 parts of vitamin As, 25-30 parts of vitamin B1s, 12-15 parts of vitamin Cs, 12-15 parts of vitamin Ds, 20-25 parts of vitamin Bs 6,25-30 parts of vitamin Bs 12,10-12 parts of dimension lifes Plain E, 10-12 part of vitamin K 3,6-8 parts of folic acid, 10-12 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-7 parts of glycine, 3-5 parts of alanine, 2-3 parts of figured silk fabrics Propylhomoserin, 6-8 part leucine, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 5-6 parts of phenylalanines, 6-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 28-30 portions of honeysuckles, 15-18 parts of radix bupleuri, 11-12 parts Folium isatidis, 8-10 part rice sprout, 10-12 parts of pine needle meals, 18-20 portions of rabdosia lophanthides, 10-12 parts of apple pomaces, 15-18 parts of cassia seeds, 12- 15 parts of Radix Astragalis, 12-15 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-12 parts of methacrylic acid/ethyl acrylate copolymerization Object, 25-30 part hydroxypropyl methyl cellulose, 25-30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2-3 parts of plasticizer, 1-2 parts of pore-foaming agents, 0.5-0.8 parts Defoaming agent.
The further preferred ratio range of each component of the present invention.
Embodiment 4
Based on the above embodiment, a kind of multi-vitamins pellet for animals, including multi-vitamins, compounded amino Acid, compound Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 30 parts of vitamin As, 30 parts of vitamin B1s, 15 parts of dimensions Raw element C, 15 parts of vitamin Ds, 23 parts of 6,30 parts of vitamin B, 12,11 parts of vitamin B vitamin Es, 11 parts of Vitamin K3s, 8 parts of leaves Acid, 11.5 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6.5 parts of glycine, 4 parts of alanine, 3 parts of valines, 8 parts of leucines, 4 parts of aspartic acids, 5 parts of R-genes, 2.5 parts of lysine hydrochlorides, 6 parts of phenylalanines, 8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 30 portions of honeysuckles, 16 parts of radix bupleuri, 12 portions of folium isatidis, 9 parts Rice sprout, 12 parts of pine needle meals, 19 portions of rabdosia lophanthides, 12 parts of apple pomaces, 18 parts of cassia seeds, 14 parts of Radix Astragalis, 13.5 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 12 parts of methacrylic acid/ethyl acrylate copolymers, 28 Part hydroxypropyl methyl cellulose, 30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2.5 parts of plasticizer, 2 parts of pore-foaming agents, 0.8 part of defoaming agent.
The comprehensive performance of combination product of the present invention, the preferably proportion of each component.
Embodiment 5
Based on the above embodiment, the preparation method of a kind of multi-vitamins pellet for animals, comprising the following steps:
S1, multi-vitamins are prepared;
S2, compound amino acid is prepared;
S3, compound Chinese medicine is prepared, compound Chinese medicine is prepared into pulvis;
S4, compound cellulose capsule core is prepared using compound cellulose, compound amino acid, compound Chinese medicine as raw material;
S5, coating solution is prepared using coating agent, coating auxiliary material as raw material, compound cellulose capsule core is placed on seed-coating machine In, coating solution being injected into seed-coating machine, compound cellulose capsule core being coated, multi-vitamins pellet is obtained after drying;
Drying temperature is 40-60 DEG C in step S5.The present invention controls the drying temperature after coating of pellets, avoids temperature mistake Nutritive value that is high and destroying pellet;
The partial size of compound cellulose capsule core is 10-60 mesh.
Preparation method of the present invention is simple, is coated with by packaging technique to pellet, improves the stability of pellet.
Test example 1
According to the preparation method in embodiment 5, respectively to formula described in embodiment 1-4, to the one kind prepared Multi-vitamins pellet for animals carries out the test of stability;Test method is as follows: multi-vitamins for animals prepared by the present invention are micro- Ball saves 3 months under conditions of 37 DEG C -40 DEG C of temperature, relative humidity 75%-80%RH, the multi-vitamins pellet for animals Attenuation rate is slower, at 3rd month, embodiment 1-4 preparation multi-vitamins pellet for animals attenuation rate within 10%, Illustrate multi-vitamins pellet high stability for animals prepared by the present invention, is conducive to the preservation of multi-vitamins pellet for animals.
Test example 2
It is examined referring to " Republic of China Veterinary Pharmacopoeia " (version in 2015) first dissolution rate with drug release determination method It surveys, it is for animals multiple to the one kind prepared respectively to formula described in embodiment 1-4 according to the preparation method in embodiment 5 Vitamin micro pill is closed to be tested;A kind of multi-vitamins pellet 2h in simulated gastric fluid for animals is equal in 1-4 of the embodiment of the present invention 3% or so are only discharged, 3h discharges 80% or so, 5h and can all discharge in simulated intestinal fluid;It follows that the present invention provides A kind of multi-vitamins pellet for animals cross stomach and do not dissolve substantially, the slow release in intestinal juice reduces the compatible change of vitamin, So that vitamin is concentrated on enteron aisle, is fully absorbed.
Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects It is described in detail, it should be understood that being not intended to limit the present invention the foregoing is merely a specific embodiment of the invention Protection scope, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include Within protection scope of the present invention.

Claims (8)

1. a kind of multi-vitamins pellet for animals, which is characterized in that including multi-vitamins, compound amino acid, compound Chinese medicine, packet Clothing agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 10-30 parts of vitamin As, 10-30 parts of vitamin B1s, 10-20 Part vitamin C, 8-15 parts of vitamin Ds, 10-30 parts of vitamin Bs 6,10-30 parts of vitamin Bs 12,8-15 parts of vitamin Es, 8-15 Part vitamin K 3,3-10 parts of folic acid, 10-15 parts of biotins;
The compound amino acid includes the component of following parts by weight: 3-8 parts of glycine, 2-10 parts of alanine, 1-6 parts of figured silk fabrics ammonia Acid, 4-10 parts of leucines, 2-6 parts of aspartic acids, 1-5 parts of R-genes, 1-6 parts of lysine hydrochlorides, 3-6 parts of phenylalanines, 3-8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 20-30 portions of honeysuckles, 10-20 parts of radix bupleuri, 10-15 parts of smalts Leaf, 8-12 part rice sprout, 10-15 parts of pine needle meals, 10-20 portions of rabdosia lophanthides, 8-15 parts of apple pomaces, 10-20 parts of cassia seeds, 5-15 parts of Huangs Stilbene, 10-20 part Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-15 parts of methacrylic acid/ethyl acrylate copolymers, 20- 40 parts of hydroxypropyl methyl celluloses, 10-30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2-8 parts of plasticizer, 1-5 parts of pore-foaming agents, 0.5-3 parts of defoaming agents.
2. a kind of multi-vitamins pellet for animals according to claim 1, which is characterized in that including multi-vitamins, again Close amino acid, compound Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 20-30 parts of vitamin As, 20-30 parts of vitamin B1s, 10-15 Part vitamin C, 10-15 parts of vitamin Ds, 15-25 parts of vitamin Bs 6,20-30 parts of vitamin Bs 12,8-12 parts of vitamin Es, 8- 12 parts of vitamin Ks 3,6-10 parts of folic acid, 10-13 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-8 parts of glycine, 2-5 parts of alanine, 1-3 parts of valines, 6-10 parts of leucines, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 4-6 parts of phenylalanines, 5-8 Part methionine;
The compound Chinese medicine includes the component of following parts by weight: 25-30 portions of honeysuckles, 15-20 parts of radix bupleuri, 10-12 parts of smalts Leaf, 8-10 part rice sprout, 10-13 parts of pine needle meals, 15-20 portions of rabdosia lophanthides, 10-15 parts of apple pomaces, 15-20 parts of cassia seeds, 10-15 parts Radix Astragali, 10-15 part Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-13 parts of methacrylic acid/ethyl acrylate copolymers, 20- 30 parts of hydroxypropyl methyl celluloses, 20-30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2-5 parts of plasticizer, 1-3 parts of pore-foaming agents, 0.5-1 parts of defoaming agents.
3. a kind of multi-vitamins pellet for animals according to claim 2, which is characterized in that including multi-vitamins, again Close amino acid, compound Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 25-30 parts of vitamin As, 25-30 parts of vitamin B1s, 12-15 Part vitamin C, 12-15 parts of vitamin Ds, 20-25 parts of vitamin Bs 6,25-30 parts of vitamin Bs 12,10-12 parts of vitamin Es, 10-12 parts of vitamin Ks 3,6-8 parts of folic acid, 10-12 parts of biotins;
The compound amino acid includes the component of following parts by weight: 6-7 parts of glycine, 3-5 parts of alanine, 2-3 parts of valines, 6-8 parts of leucines, 2-4 parts of aspartic acids, 3-5 parts of R-genes, 2-4 parts of lysine hydrochlorides, 5-6 parts of phenylalanines, 6-8 parts Methionine;
The compound Chinese medicine includes the component of following parts by weight: 28-30 portions of honeysuckles, 15-18 parts of radix bupleuri, 11-12 parts of smalts Leaf, 8-10 part rice sprout, 10-12 parts of pine needle meals, 18-20 portions of rabdosia lophanthides, 10-12 parts of apple pomaces, 15-18 parts of cassia seeds, 12-15 parts Radix Astragali, 12-15 part Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 10-12 parts of methacrylic acid/ethyl acrylate copolymers, 25- 30 parts of hydroxypropyl methyl celluloses, 25-30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2-3 parts of plasticizer, 1-2 parts of pore-foaming agents, 0.5-0.8 parts of defoamings Agent.
4. a kind of multi-vitamins pellet for animals according to claim 3, which is characterized in that including multi-vitamins, again Close amino acid, compound Chinese medicine, coating agent, coating auxiliary material;
The multi-vitamins include the component of following parts by weight: 30 parts of vitamin As, 30 parts of vitamin B1s, 15 parts of vitamins C, 15 parts of vitamin Ds, 23 parts of 6,30 parts of vitamin B, 12,11 parts of vitamin B vitamin Es, 11 parts of vitamin Ks, 3,8 parts of folic acid, 11.5 part biotin;
The compound amino acid includes the component of following parts by weight: 6.5 parts of glycine, 4 parts of alanine, 3 parts of valines, 8 parts Leucine, 4 parts of aspartic acids, 5 parts of R-genes, 2.5 parts of lysine hydrochlorides, 6 parts of phenylalanines, 8 parts of methionine;
The compound Chinese medicine includes the component of following parts by weight: 30 portions of honeysuckles, 16 parts of radix bupleuri, 12 portions of folium isatidis, 9 portions of paddy Bud, 12 parts of pine needle meals, 19 portions of rabdosia lophanthides, 12 parts of apple pomaces, 18 parts of cassia seeds, 14 parts of Radix Astragalis, 13.5 parts of Radix Ophiopogonis;
The coating agent includes the component of following parts by weight: 12 parts of methacrylic acid/ethyl acrylate copolymers, 28 parts of hydroxyls Propyl methocel, 30 parts of Arabic gums;
The coating auxiliary material includes the component of following parts by weight: 2.5 parts of plasticizer, 2 parts of pore-foaming agents, 0.8 part of defoaming agent.
5. a kind of multi-vitamins pellet for animals according to claim 1, which is characterized in that further include following parts by weight Component: the plasticizer is triethyl citrate, the pore-foaming agent be polyethylene glycol, defoaming agent be high-carbon alcohol fatty acid ester answer Close object.
6. a kind of preparation side of multi-vitamins pellet for animals described in any one of -5 claims according to claim 1 Method, which comprises the following steps:
S1, multi-vitamins are prepared;
S2, compound amino acid is prepared;
S3, compound Chinese medicine is prepared, compound Chinese medicine is prepared into pulvis;
S4, compound cellulose capsule core is prepared using compound cellulose, compound amino acid, compound Chinese medicine as raw material;
S5, coating solution is prepared using coating agent, coating auxiliary material as raw material, compound cellulose capsule core is placed in seed-coating machine, Coating solution is injected into seed-coating machine to be coated compound cellulose capsule core, and multi-vitamins pellet is obtained after drying.
7. a kind of preparation method of multi-vitamins pellet for animals according to claim 6, which is characterized in that in step S5 Drying temperature is 40-60 DEG C.
8. a kind of preparation method of multi-vitamins pellet for animals according to claim 6, which is characterized in that composite fibre The partial size of vegetable pill core is 10-60 mesh.
CN201811587316.XA 2018-12-25 2018-12-25 A kind of multi-vitamins pellet for animals and preparation method thereof Pending CN109511785A (en)

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WO2020221572A1 (en) * 2019-04-30 2020-11-05 Dsm Ip Assets B.V. New delivery system for fat soluble vitamins

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