CN109507622A - MR imaging method and system - Google Patents
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Abstract
The embodiment of the invention discloses a kind of MR imaging method and systems.This method comprises: applying non-layer choosing inversion pulse to detected object；In the setting heart movement phase phase in the first cardiac cycle, excites the multilayer of heart simultaneously using default imaging sequence, acquire the multilayer aliasing t1 weighted image of heart；In the setting heart movement phase phase in the second cardiac cycle, the default imaging sequence acquisition reference picture of default flip angle excitation is utilized；First cardiac cycle same single-breath hold corresponding with the second cardiac cycle, and be adjacent cardiac cycle, reference picture is corresponding with one layer in multilayer；It is rebuild using the inversion recovery that reference picture carries out interlayer solution aliasing and phase sensitive to multilayer aliasing t1 weighted image, obtains the target t1 weighted image of each layer of heart.Through the above technical solutions, realizing under the premise of guaranteeing picture quality, the data acquisition efficiency of magnetic resonance is improved.
Description
Technical field
The present embodiments relate to medical mr techniques more particularly to a kind of MR imaging method and systems.
Background technique
Myocardial infarction (abbreviation heart infarction) is a kind of serious heart disease.It is not complete for myocardial activity after heart infarction occurs
The cardiac muscle (can referred to as save cardiac muscle) that totally disappeared mistake, the mode that recovery heart muscle perfusion can be used improve heart function, and to living without cardiac muscle
Property infarcted myocardium carry out heart muscle perfusion can then induce fatal arrhythmia.Therefore needing to assess myocardial activity can save to differentiate
Cardiac muscle and infarcted myocardium, to assess the probability that myocardial function restores after Reperfu- sion.
Magnetic resonance imaging at present (MRI) is considered as one of assessment effective means of myocardial activity.In order to preferably
Myocardial activity is assessed, needs to obtain the t1 weighted image with preferable picture contrast.For this purpose, generalling use phase sensitive
Inversion-recovery sequence (Phase-Sensitive Inversion Recovery, PSIR) carries out magnetic resonance imaging.Utilize the sequence
Arrange the principle of imaging substantially are as follows: in the same phase phase of the adjacent heart cycles after an inversion pulse, first aroused in interest
Period obtains t1 weighted image, the second cardiac cycle obtains low flip angle proton density image (also referred to as reference picture),
Then image reconstruction is carried out with the reversion algorithm for reconstructing of phase sensitive.Thus obtained MRI reconstruction image can be during reversion
Retain magnetized polarity, to obtain consistent and relatively apparent comparison in broader inversion recovery time (TI) range of choice
Degree.But PSIR can only obtain a high-resolution slice in single breath-hold, this undoubtedly will increase entire in clinical application
Cardiac imaging when consume.
Meanwhile while in mr imaging technique multilayer excitation imaging technique (Simultaneous Multi-Slice,
SMS) allow to excite several lamellas in the same time, to improve the data acquisition efficiency of magnetic resonance.But the imaging technique institute
Obtained acquisition data are multilayer wall aliasings, need one width reference picture of additional acquisition to carry out the solution aliasing of data.
SMS technology in this way needs individual single-breath hold just to obtain the reference picture, consumption when equally will increase entire cardiac imaging.
In short, obtaining consumption when entire cardiac image is required to longer using existing mr imaging technique, cause into
As low efficiency.
Summary of the invention
The embodiment of the present invention provides a kind of MR imaging method and system, to realize in the premise for guaranteeing picture quality
Under, cardiac magnetic resonance images are more rapidly obtained, the data acquisition efficiency of magnetic resonance is improved, reduces cardiac magnetic resonance
It is consumed when imaging.
In a first aspect, the embodiment of the invention provides a kind of MR imaging methods, comprising:
Non- layer choosing inversion pulse is applied to detected object；
In the setting heart movement phase phase in the first cardiac cycle, the more of heart are excited simultaneously using default imaging sequence
Layer, and acquire the multilayer aliasing t1 weighted image of the heart；
In the setting heart movement phase phase in the second cardiac cycle, the described default of default flip angle excitation is utilized
Imaging sequence acquires reference picture；Wherein, first cardiac cycle same single-breath hold corresponding with the second cardiac cycle, and it is described
First cardiac cycle and second cardiac cycle are adjacent cardiac cycle, one layer in the reference picture and the multilayer
It is corresponding；
The anti-of interlayer solution aliasing and phase sensitive is carried out to the multilayer aliasing t1 weighted image using the reference picture
Turn restoration and reconstruction, obtains the target t1 weighted image of each layer of the heart.
Second aspect, the embodiment of the invention also provides a kind of magnetic resonance imaging system, which includes:
Electrocardiograph, MR scanner, and the processor communicated to connect with the electrocardiograph and the MR scanner；
The electrocardiograph, for generating the ecg-gating signal of detected object；
The processor, is used for:
The MR scanner is triggered according to the ecg-gating signal, and non-layer choosing inversion pulse is applied to detected object；
Setting heart movement phase of the MR scanner in the first cardiac cycle is controlled according to the ecg-gating signal
In phase, the multilayer of heart is excited simultaneously using default imaging sequence, and acquire the multilayer aliasing t1 weighted image of the heart；
Setting heart fortune of the MR scanner in the second cardiac cycle is controlled according to the ecg-gating signal
In dynamic phase phase, the default imaging sequence acquisition reference picture of default flip angle excitation is utilized；Wherein, the described first week aroused in interest
Phase same single-breath hold corresponding with the second cardiac cycle, and first cardiac cycle and second cardiac cycle are the adjacent heart
Dynamic period, the reference picture are corresponding with one layer in the multilayer；
The anti-of interlayer solution aliasing and phase sensitive is carried out to the multilayer aliasing t1 weighted image using the reference picture
Turn restoration and reconstruction, obtains the target t1 weighted image of each layer of the heart.
The embodiment of the present invention is by applying non-layer choosing inversion pulse to detected object；Setting in the first cardiac cycle
In heart movement phase phase, the multilayer of heart is excited simultaneously using default imaging sequence, and acquire the multilayer aliasing T1 of the heart
Weighted image；In the setting heart movement phase phase in the second cardiac cycle, the described pre- of default flip angle excitation is utilized
It is set as realizing as sequence acquisition reference picture and combines multilayer excitation simultaneously using the inversion recovery imaging technique of phase sensitive
Imaging technique carries out the data acquisition of cardiac magnetic resonance, has reached under the premise of not reducing cardiac magnetic resonance images quality, has mentioned
The data acquisition efficiency of high cardiac magnetic resonance.By carrying out layer to the multilayer aliasing t1 weighted image using the reference picture
Between solve the inversion recovery of aliasing and phase sensitive and rebuild, obtain the target t1 weighted image of each layer of the heart, realize utilization
Same width reference picture carries out interlayer solution aliasing and single layer image is rebuild, to reduce the times of collection of reference picture, in turn
The data acquisition for reducing cardiac magnetic resonance is time-consuming, further improves data acquisition efficiency, also improves to a certain extent
Imaging efficiency.
Detailed description of the invention
Fig. 1 is the flow chart of one of the embodiment of the present invention one MR imaging method；
Fig. 2A is the operation schematic diagram of the cardiac magnetic resonance data acquisition in the embodiment of the present invention one；
Fig. 2 B is the operation schematic diagram of the cardiac magnetic resonance data acquisition in the embodiment of the present invention two；
Fig. 3 is the flow chart of one of the embodiment of the present invention two MR imaging method；
Fig. 4 is the flow chart of one of the embodiment of the present invention three MR imaging method；
Fig. 5 is the structural schematic diagram of one of the embodiment of the present invention four magnetic resonance imaging system.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Embodiment one
MR imaging method provided in this embodiment is applicable to carry out FastMRI to heart.This method can
To be executed by MR imaging apparatus, which can be realized that the device can integrate by the mode of software and/or hardware
It can carry out in the Medical Devices of magnetic resonance imaging.Referring to Fig. 1, the method for the present embodiment specifically comprises the following steps:
S110, non-layer choosing inversion pulse is applied to detected object.
Specifically, during carrying out magnetic resonance imaging to heart, in order to be stablized and effective cardiac image, the heart is utilized
The self-disciplining of dirty movement come select data acquire opportunity.Magnetostatic field B is in when it is implemented, extracting0In detected object
Segmented ecg-gating (Electrocardiograph, ECG) is used as trigger signal, applies the anti-of a non-layer choosing to the object
Turn pulse.The non-layer choosing inversion pulse can reduce blood flow artifact, improve picture quality to a certain extent.
S120, in the setting heart movement phase phase in the first cardiac cycle, excite the heart simultaneously using default imaging sequence
Dirty multilayer, and acquire the multilayer aliasing t1 weighted image of the heart.
Wherein, the first cardiac cycle referred in single-breath hold, the week aroused in interest of some in cardiac cycle motion process
Phase can be the first cardiac cycle applied after non-layer choosing inversion pulse, be also possible to first cardiac cycle interval
Other cardiac cycles of odd number cardiac cycle.The setting heart movement phase mutually refers to some in the entire cardiac cycle of heart
Phase phase, heart movement is considered as opposing stationary in a phase phase, such as the setting heart movement phase is mutually the diastole of heart.If
Only the complete image for needing to obtain heart in some phase phase (being denoted as target phase phase), then the setting heart movement phase mutually just
For target phase phase.If necessary to obtain heart in the complete image of each phase phase, then every complete image for completing a phase phase obtains
After taking, according to the sequence of each phase phase, mutually it is change stride with 1 phase, sequentially changes setting heart movement phase phase.Before i.e.
The acquisition for stating multilayer aliasing t1 weighted image is executable multiple.
Default imaging sequence refers to preset pulse train for magnetic resonance data acquisition.Illustratively, described
Default imaging sequence include quickly damage gradin-echo, spin-echo sequence, gradin-echo, inversion-recovery sequence or
One of free stable state precession sequence or a variety of combinations are balanced, i.e., for presetting the type of imaging sequence simultaneously in the present embodiment
It is not particularly limited.Gradient echoes sequence is quickly preferably damaged using two dimension in the present embodiment, can protrude squeeze into this way
The T1 contrast between cardiac muscle and infarcted myocardium can be saved after contrast agent.
Specifically, A referring to fig. 2 is acquired after applying non-layer choosing inversion pulse using the segmented of ECG triggering, the
In setting heart movement phase phase (such as diastole) in one cardiac cycle, apply the default imaging sequence of default flip angle (such as 25 °)
The imaging technique SMS of multilayer excitation excites n piece of detected object heart simultaneously while column using accelerated factor MB are n
Layer, to carry out the data acquisition of original t1 weighted image.Staggered phase coding mode is selected when data acquire, to obtain the heart
(i.e. multilayer aliasing t1 weighted image or T1 weight IR to the t1 weighted image of the dirty n-layer slice aliasing in setting heart movement phase phase
Data), n is the positive integer more than or equal to 2 here.Such as n=2, then the T1 weighting IR data collected for the first time are the
One layer and the second layer (lamella or slice) corresponding partial data；Collect for the second time T1 weighting IR data be first layer and
The corresponding another part data of the second layer (lamella or slice), the T1 for acquiring to obtain twice can shapes after weighting IR data solution aliasing
At the corresponding space the K total data of first layer, the corresponding space the K total data of the second layer.
SMS technology in the present embodiment is preferably phase-modulation multilayer excitation technique SMS-CAIPIRINHA simultaneously, so as to
Increase coil space change of sensitivity, improves the picture quality of subsequent reconstruction image.For example, accelerated factor m=2 is taken, that is,
Two lamellas of primary excitation heart, and have the relative displacement of FOV/2 between two layers, in this way can one acquisition can simultaneously obtain
The t1 weighted image of 2 layers of aliasing improves the data acquisition efficiency of cardiac magnetic resonance.
In S130, the setting heart movement phase phase in the second cardiac cycle, the institute of default flip angle excitation is utilized
State default imaging sequence acquisition reference picture.
Wherein, refer to the cardiac cycle next time closely followed after the first cardiac cycle the second cardiac cycle.Reference picture is
Refer to the reference image in TI weighted image reconstruction process, such as can be proton density image, at least should be that center is completely adopted
Single layer image.It should be pointed out that the acquisition of the corresponding reference picture of different layers independently carries out, and t1 weighted image
Acquisition mode is that multilayer acquires simultaneously.In this embodiment, accelerated factor n=2, each cardiac cycle acquisition can get two slices
The corresponding t1 weighted image of aliasing, and the corresponding reference picture of every slicing layer individually acquires, and is respectively completed to respective slice
The solution aliasing and phasing of layer T1 image.Illustratively, first cardiac cycle is corresponding with the second cardiac cycle with primary
Hold one's breath, and first cardiac cycle and second cardiac cycle are adjacent cardiac cycle, the reference picture with it is described
One layer in multilayer is corresponding.When it is implemented, the first cardiac cycle and the second cardiac cycle correspond to in single-breath hold
Successive heartbeat twice, i.e. the first cardiac cycle and the second cardiac cycle are adjacent.
Default flip angle is the flip angle of the excitation pulse set when pulse train design.This is default when obtaining reference picture
Flip angle is set as a lesser angle, such as 5 °, to reach the phase change ignoring signal itself and introducing, thus more preferably
The purpose for the phase change that ground estimating system introduces.
Specifically, mixed acquiring multilayer the first cardiac cycle according to the inversion recovery imaging technical principle of phase sensitive
After the data of folded t1 weighted image, reference picture should be acquired in the same phase phase of the second cardiac cycle.Therefore second
In setting heart movement phase phase in cardiac cycle, the default imaging sequence of default flip angle is excited, to acquire reference picture
Data, and obtain a width single layer reference picture.PSIR technology is used in the present embodiment, can be further ensured that subsequent reconstruction
The picture quality of image.
S140, interlayer solution aliasing and phase sensitive are carried out to the multilayer aliasing t1 weighted image using the reference picture
Inversion recovery rebuild, obtain the target t1 weighted image of each layer of the heart.
Wherein, target t1 weighted image refers to no aliasing and eliminates artifact caused by phase, the full visual field of single layer
(FOV) t1 weighted image.
Specifically, PSIR technology is utilized during acquiring due to above-mentioned data, and is adopted in the data of t1 weighted image
SMS-CAIPIRINHA technology has been used in combination in the collection stage, therefore passes through S110~S130 multilayer aliasing t1 weighted image obtained
Be multiple lamellas data aliasing together, and there are artifacts caused by phase in every tomographic image, therefore need to carry out layer to it
Between solve aliasing and comprising phasing in layer and plural number take the operations such as real part phase sensitive inversion recovery rebuild.
In view of in heart phase phase identical in single breath-hold, cardiac shape and coil sensitivity are regarded as not changing
, therefore to carry out interlayer solution aliasing, but one is reused there is no additional reference picture acquisition is carried out again in the present embodiment
The reference picture obtained in secondary collection process carries out above-mentioned figure to the multilayer aliasing t1 weighted image obtained in homogeneous collection process
As processing, to obtain the target t1 weighted image of each lamella of detected object heart.It is referred in the present embodiment as a result,
The times of collection of image is reduced, and further increases data acquisition efficiency.And different image processing process is joined using same width
Image is examined, the part reprocessing operation of reference picture can be reduced, to improve image reconstruction efficiency (also referred to as imaging effect
Rate).
The technical solution of the present embodiment, by applying non-layer choosing inversion pulse to detected object；In the first cardiac cycle
In setting heart movement phase phase in, excite the multilayer of heart simultaneously using default imaging sequence, and acquire the more of the heart
Layer aliasing t1 weighted image；In the setting heart movement phase phase in the second cardiac cycle, excited using default flip angle
The default imaging sequence acquisition reference picture, realize using phase sensitive inversion recovery imaging technique joint simultaneously it is more
The imaging technique of layer excitation carries out the data acquisition of cardiac magnetic resonance, has reached before not reducing cardiac magnetic resonance images quality
It puts, significantly improves the data acquisition efficiency of cardiac magnetic resonance.By being added using the reference picture to the multilayer aliasing T1
Weight graph picture carries out interlayer solution aliasing and the inversion recovery of phase sensitive is rebuild, and obtains the target T1 weighted graph of each layer of the heart
Picture realizes and carries out interlayer solution aliasing and single layer image reconstruction using same width reference picture, to reduce reference picture
Times of collection, and then the data acquisition for reducing cardiac magnetic resonance is time-consuming, data acquisition efficiency is further improved, also certain
Imaging efficiency is improved in degree.
Based on the above technical solution, described to hold one's breath comprising repeatedly, and held one's breath every time comprising at least one set of described the
One cardiac cycle and second cardiac cycle, to complete the magnetic resonance imaging to the heart.
Specifically, above-mentioned technical proposal describes the process of a cardiac magnetic resonance data acquisition and image reconstruction, only
The target t1 weighted image of n lamella under a phase phase can be obtained.And in order to meet clinical application, it at least needs to obtain one
Complete cardiac image under phase phase, therefore need to carry out multiple cardiac magnetic resonance data acquisition and image reconstruction.Also it just needs tested
Survey object hold one's breath i time, hold one's breath every time in include the first cardiac cycle of j group and second cardiac cycle, every group of first week aroused in interest
The technical solution of phase and data acquisition and the same S120~S140 of image reconstruction process in second cardiac cycle, in this way
M=i*j data acquisition and image reconstruction are carried out altogether.If necessary to obtain heart in the complete image of each phase phase, such as 50
Phase phase then also needs to repeat the above process 50*m times.
It should be noted that under identical radio-frequency pulse quantity, being for the complete image acquisition process of a phase phase
The reference picture of the more single layers of acquisition, needs to modify the sampling configuration of reference picture, so that the collecting part quilt of reference picture
If being equably divided into stem portion.For example, n-layer image is turned over by m (m > n) inversion recovery (inversion recovery, IR)
Turn to complete while acquiring, then each lamella only assigns to reference picture collecting part (the i.e. phase code PE line of m/n IR overturning
Number tails off).The reference picture of lamella single so only collects that center is completely adopted and resolution ratio is the k-space of 1/n.
Embodiment two
The present embodiment on the basis of the above embodiment 1, to " being added using the reference picture to the multilayer aliasing T1
Weight graph picture carries out interlayer solution aliasing and the inversion recovery of phase sensitive is rebuild, and obtains the target T1 weighted graph of each layer of the heart
Picture " is advanced optimized.Wherein details are not described herein for the explanation of term identical or corresponding with the various embodiments described above.Referring to
Fig. 3, MR imaging method provided in this embodiment include:
S310, non-layer choosing inversion pulse is applied to detected object.
S320, in the setting heart movement phase phase in the first cardiac cycle, excite the heart simultaneously using default imaging sequence
Dirty multilayer, and acquire the multilayer aliasing t1 weighted image of the heart.
In S330, the setting heart movement phase phase in the second cardiac cycle, the institute of default flip angle excitation is utilized
State default imaging sequence acquisition reference picture.
Optionally, the acquisition of multi-layer data can carry out in different cycles, to obtain the data of not same period phase.Specifically,
B referring to fig. 2 is acquired, in the first cardiac cycle after applying non-layer choosing inversion pulse using the segmented of ECG triggering
It sets in heart movement phase phase (such as diastole), applies the default imaging sequence of default flip angle (such as 25 °), utilize accelerated factor
The imaging technique SMS of n (n >=2) layer excitation excites n lamella of detected object heart simultaneously while MB is 2, to carry out original
The data of the t1 weighted image of beginning acquire.Staggered phase coding mode is selected when data acquire, to obtain heart in the setting heart
The t1 weighted image (i.e. multilayer aliasing t1 weighted image) of the n-layer slice aliasing of dirty movement phase phase, the T1 collected for the first time
Weight the first part that IR data are first layer and the corresponding space K of the second layer (lamella or slice)；It collects for the second time
T1 weights the second part that IR data are first layer and the corresponding space K of the second layer (lamella or slice)；Data have acquired twice
First layer reference data can be all corresponded to afterwards.Further, the T1 weighting IR data collected for the third time are first layer and second
The first part in the corresponding space K of layer (lamella or slice)；4th time the T1 weighting IR data collected are similarly first layer
The second part in the corresponding space K with the second layer (lamella or slice) can all correspond to second layer reference after data have acquired twice
Data.The corresponding space the K total data of first layer, second can be formed after four T1 weighting IR data solution aliasings for acquiring to obtain
The layer corresponding space K total data.
S340, interlayer solution aliasing is carried out to the multilayer aliasing t1 weighted image using the reference picture, obtains each layer
Initial t1 weighted image.
Wherein, initial t1 weighted image refers to single layer, does not carry out the t1 weighted image of image reconstruction process.
Specifically, spatial coil sensitivity information is calculated using reference picture, is believed later using the spatial coil sensitivity
Breath carries out interlayer solution aliasing to multilayer aliasing t1 weighted image, obtains the initial t1 weighted image of each lamella.Such as when m=2
Just the initial t1 weighted image of 2 lamellas is obtained.
Illustratively, S340 includes: using the reference picture, based on the general self calibration parallel acquisition algorithm of layering and spirit
Sensitivity coding and general self calibration parallel acquisition unified algorithm, carry out interlayer solution aliasing to the multilayer aliasing t1 weighted image,
Obtain the initial t1 weighted image of each layer.
Specifically, above-mentioned spatial coil sensitivity information calculates and the process of interlayer solution aliasing can be general certainly using layering
Calibrate parallel acquisition algorithm Split-slice GRAPPA and sensitivity encoding and general self calibration parallel acquisition unified algorithm
SENSE/GRAPPA(sensitivity encoding/Generalized autocalibrating partially
Parallel acquisitions) it realizes.For example, exciting simultaneously and for two layers without by phase-modulation aliased image
It rebuilds, two layers of the reference picture obtained respectively is stitched together first using SENSE/GRAPPA technology, constructs an extension
To the two dimensional image of two times of FOV, the information in layer direction will be selected to be transformed into phase-encoding direction, so that the image after this extension can
To include that the information aliased image of all three-dimensionals then can be considered two times of lack samplings to stitching image, by the k-space of aliased image
Data are evenly distributed in the k-space of two times of FOV, utilize the k-space centre data for the stitching image that reference picture is constructed
K-space operator is calculated, finally the k-space data of aliased image after extension is filled, is not had after Fourier transformation
K spatial convoluted core is calculated according to reference picture in the stitching image Split-slice GRAPPA algorithm of aliasing, utilizes the K later
Spatial convoluted core separates the data of multilayer aliasing, and then obtains the fully sampled initial t1 weighted image in the space each lamella K.
S350, be utilized respectively the reference picture to initial t1 weighted image described in every layer carry out phase sensitive reversion it is extensive
It is multiple to rebuild, obtain the target t1 weighted image of each layer of the heart.
Specifically, for the initial t1 weighted image of each lamella, the phase of system introducing is carried out using reference picture
The estimation of position variation, and phasing is carried out to the initial t1 weighted image with plural form, to carry out phase sensitive
Inversion recovery is rebuild, and the target t1 weighted image of each lamella is obtained.
Illustratively, S350 includes: to obtain plural reference image phase according to the reference picture；Utilize the plural number ginseng
Image phase is examined, phasing is carried out to initial t1 weighted image described in every layer respectively, obtains each layer real number t1 weighted image；Point
It is other that the reference picture and every layer of real number t1 weighted image are normalized, obtain the target T1 weighting of each layer
Image.
Specifically, phase estimation is carried out using reference picture, obtains reference picture phase, because it is plural form, therefore claimed
For plural reference image phase.Then, it is carried out using initial t1 weighted image of the plural reference image phase to each lamella
Phasing obtains the correction t1 weighted image that each lamella has plural form.Later, it can refer to following formula to each
The correction t1 weighted image of layer carries out that real part is taken to operate, and obtains the real number t1 weighted image that each layer has real number form
Wherein, real expression takes real part, and conj expression takes conjugation, IjFor
Correct t1 weighted image, IrefFor reference picture.
Finally, obtaining reference amplitude image based on reference picture, and it is smoothed.Each real number T1 is added again
Weight graph picture and smoothed out reference amplitude image carry out it is point-to-point be divided by, obtain each layer target t1 weighted image.
The technical solution of the present embodiment, by carrying out layer to the multilayer aliasing t1 weighted image using the reference picture
Between solve aliasing, obtain the initial t1 weighted image of each layer；The reference picture is utilized respectively to initial t1 weighted image described in every layer
The inversion recovery for carrying out phase sensitive is rebuild, and the target t1 weighted image of each layer of the heart is obtained.It realizes successively using same
One width reference picture carries out interlayer solution aliasing and the inversion recovery of phase sensitive is rebuild, and improves the utilization rate of reference picture, from
And improve data acquisition efficiency and imaging efficiency.
Embodiment three
The present embodiment has carried out further limit on the basis of each above-described embodiment, to " multilayer aliasing t1 weighted image "
It is fixed.On this basis further to " using the reference picture to multilayer aliasing t1 weighted image progress interlayer solution aliasing
Rebuild with the inversion recovery of phase sensitive, obtain the target t1 weighted image of each layer of the heart " it is optimized.Wherein with it is upper
State that each embodiment is identical or the explanation of corresponding term details are not described herein.Referring to fig. 4, magnetic resonance imaging provided in this embodiment
Method includes:
S410, non-layer choosing inversion pulse is applied to detected object.
S420, in the setting heart movement phase phase in the first cardiac cycle, excite the heart simultaneously using default imaging sequence
Dirty multilayer, and acquire the multilayer aliasing t1 weighted image of the heart, the corresponding space K of the multilayer aliasing t1 weighted image
For lack sampling.
Specifically, for the data acquisition of t1 weighted image, in addition to the inversion recovery imaging technique in phase sensitive
On the basis of PSIR except joint multilayer excitation simultaneously imaging technique SMS technology, further combine parallel acquisition technique
(Partially Parallel Acquisition,PPA).PPA technology carries out data acquisition using lack sampling K spatial model,
To reduce phase encoding step, to achieve the purpose that improve data sampling efficiency.It is to be designed in pulse train when specific implementation
When, based on PSIR technology, in combination with SMS technology and PPA technology.So obtained using pulse train excitation heart
The corresponding acquisition data of original t1 weighted image, be not only the aliased data of multiple lamellas, and the data of each lamella
It is the space K lack sampling.
In S430, the setting heart movement phase phase in the second cardiac cycle, the institute of default flip angle excitation is utilized
State default imaging sequence acquisition reference picture.
It should be understood that the data acquisition of reference picture is identical as PSIR+SMS, only difference is that for every
The IR reversion quantity of layer reference picture is less, and obtained reference picture resolution ratio is also more lower.
S440, interlayer solution aliasing is carried out to the multilayer aliasing t1 weighted image using the reference picture, obtains each layer
Initial t1 weighted image.
S450, the reference picture is utilized respectively to aliasing is solved in the progress layer of initial t1 weighted image described in every layer, obtain K
The fully sampled each layer in space completely adopts t1 weighted image.
Specifically, the initial t1 weighted image of each single layer obtained for interlayer solution aliasing, since it owes to adopt for the space K
The data of sample, i.e. aliased data in layer, therefore need to carry out owing to adopt to it filling of data.And solution aliasing is also required to utilize sky in layer
Between Coil sensitivity information, therefore still obtained using being calculated based on width reference picture during interlayer solution aliasing in the present embodiment
Spatial coil sensitivity information carries out solving aliasing in layer, it is fully sampled to obtain the space K to the initial t1 weighted image of each lamella
Each layer completely adopt t1 weighted image.For example, the K spatial convoluted core obtained using above-mentioned calculating, is removed based on GRAPPA algorithm
Aliasing in layer.
S460, be utilized respectively the reference picture to completely adopted described in every layer t1 weighted image carry out phase sensitive reversion it is extensive
It is multiple to rebuild, obtain the target t1 weighted image of each layer of the heart.
The explanation of the step can be found in the explanation of S350, and the object that only inversion recovery of phase sensitive is rebuild is as at the beginning of every layer
Beginning t1 weighted image is changed to every layer and completely adopts t1 weighted image.
By above description it is found that reference picture reuses three times in the present embodiment, it is respectively used to as calibration data
The multi-layer data of separation while acquisition eliminates aliasing in the layer generated by PPA as calibration data, and estimates each lamella
Background phase is to carry out PSIR reconstruction.
The technical solution of the present embodiment is swashed by the inversion recovery imaging technique PSIR joint while multilayer in phase sensitive
On the basis of sending out imaging technique SMS, then combine parallel imaging technique PPA, designed for the pulse train of cardiac magnetic resonance imaging,
And using ecg-gating ECG as trigger signal, the acquisition of cardiac magnetic resonance data and image reconstruction are carried out using the pulse train of design,
It realizes in phase-encoding direction and selects four times of layer direction to accelerate, further improve the data acquisition effect of cardiac magnetic resonance
Rate.
In order to verify above-mentioned PSIR+SMS and PSIR+SMS+PPA frame, using quick flow-disturbing GRE PSIR of conventional segmented,
PSIR+SMS and PSIR+SMS+PPA has carried out die body emulation and experiment in vivo, shoots 20 views under every kind of frame.Every
In secondary acquisition, two slices individually or are simultaneously imaged, and segmentation electrocardiogram is realized by the virtual ECG signal of application
Triggering collection.The imaging parameters used during die body simulating, verifying are shown in Table 1.By this time it is demonstrated experimentally that above-mentioned PSIR+SMS
It can obviously reduce the data acquisition time of cardiac magnetic resonance with PSIR+SMS+PPA frame, improve data acquisition efficiency.
The imaging parameters of table 1 traditional PS IR, PSIR+SMS and PSIR+SMS+PPA
It is the embodiment of magnetic resonance imaging system provided in an embodiment of the present invention below, the device and the various embodiments described above
MR imaging method belongs to the same inventive concept, in the embodiment of magnetic resonance imaging system in the details of not detailed description
Hold, the embodiment of above-mentioned MR imaging method can be referred to.
Example IV
The present embodiment provides a kind of magnetic resonance imaging systems 500, and referring to Fig. 5, which is specifically included: electrocardiograph 510,
MR (Magnetic Resonance, MR) scanner 520, and communicated to connect with the electrocardiograph and the MR scanner
Processor 530；
The electrocardiograph 510, for generating the ecg-gating signal of detected object；
The processor 530, is used for:
The ecg-gating signal generated according to electrocardiograph 510 triggers the MR scanner 520 to detected object application
Non- layer choosing inversion pulse；
The ecg-gating signal generated according to electrocardiograph 510 controls the MR scanner 520 in the first cardiac cycle
Setting heart movement phase phase in, excite the multilayer of heart simultaneously using default imaging sequence, and acquire the multilayer of the heart
Aliasing t1 weighted image；
The ecg-gating signal generated according to electrocardiograph 510 controls the MR scanner 520 in the second cardiac cycle
The setting heart movement phase phase in, utilize default flip angle excitation the default imaging sequence acquisition reference picture；Its
In, the first cardiac cycle same single-breath hold corresponding with the second cardiac cycle, and first cardiac cycle and described second
Cardiac cycle is adjacent cardiac cycle, and the reference picture is corresponding with one layer in the multilayer；
Using the collected reference picture of MR scanner 520 to the collected multilayer aliasing T1 weighted graph of MR scanner 520
Inversion recovery as carrying out interlayer solution aliasing and phase sensitive is rebuild, and the target t1 weighted image of each layer of the heart is obtained.
Certainly, it will be understood by those skilled in the art that processor 530 can also realize that any embodiment of that present invention is provided
MR imaging method technical solution.
The magnetic resonance imaging system 500 that Fig. 5 is shown is only an example, function to the embodiment of the present invention and should not be made
With range band come any restrictions.
As shown in figure 5, the magnetic resonance imaging system 500 is based on the above technical solution, it further include output device
540。
Processor 530 can monitor or control simultaneously electrocardiograph 510, MR scanner 520 and output device 540.Processor
530 may include central processing unit (Central Processing Unit, CPU), specialized application integrated circuit
(Application-Specific Integrated Circuit, ASIC), dedicated instruction processor (Application
Specific Instruction Set Processor, ASIP), graphics processing unit (Graphics Processing
Unit, GPU), physical processor (Physics Processing Unit, PPU), digital signal processor (Digital
Processing Processor, DSP), field programmable gate array (Field-Programmable Gate Array,
FPGA), the combination of one or more of arm processor etc..
Output device 540, such as display can show the magnetic resonance image of area-of-interest.Further, output device
540 may also display the height, weight, age, imaging position and the working condition of MR scanner 520 etc. of subject.Output dress
The type for setting 540 can be cathode-ray tube (CRT) output device, liquid crystal output device (LCD), organic light emission output device
(OLED), the combination of one or more of plasma output device etc..
Magnetic resonance imaging system 500 can connect local area network (Local Area Network, LAN), wide area network (Wide
Area Network, WAN), common network, private network, proprietary network, public switch telephone network (Public Switched
Telephone Network, PSTN), any combination of internet, wireless network, virtual network or above-mentioned network.
MR scanner 520 includes MR signal acquisition module, MR control module and MR data memory module.Wherein, MR signal
Obtaining module includes magnet unit and radio frequency unit.Magnet unit mainly includes generating the main magnet and generation gradient of B0 main field
Gradient component.The main magnet for including in magnet unit can be permanent magnet or superconducting magnet, and gradient component mainly includes gradient
Current amplifier (AMP), gradient coil, gradient component also may include three autonomous channels Gx, Gy, Gz, each gradient amplifier
A corresponding gradient coil in gradient coil set is excited, the gradient fields for generating additional space encoded signal are generated, with right
Magnetic resonance signal carries out space orientation.Radio frequency unit mainly includes radio-frequency sending coil and RF receiving coil, radio-frequency transmissions line
Circle is for subject or human-body emitting RF pulse signal, RF receiving coil to be used to receive the magnetic resonance letter acquired from human body
Number, and according to the difference of function, the radio-frequency coil for forming radio frequency unit can be divided into body coil and local coil.In one embodiment
In, the type of body coil or local coil can be bird basket coil, solenoid-shaped coil, saddle-type coil, Helmholtz's line
Circle, array coil, circuit coil etc..In a specific embodiment, local coil is set as array coil, and the array coil
It may be configured as 4 channel patterns, 8 channel patterns or 16 channel patterns.Magnet unit and radio frequency unit constitute open low field magnetic
Resonance device or enclosed type superconducting magnetic resonance device.
MR control module can monitor the MR signal acquisition module comprising magnet unit and radio frequency unit, MR data processing mould
Block.Specifically, MR control module can receive the information or pulse parameter that MR signal acquisition module is sent；In addition, MR controls mould
The treatment process of the also controllable MR data processing module of block.In one embodiment, MR control module is also connected with comprising pulse
Sequencer, gradient waveform generator, transmitter and receiver etc. are receiving user after the instruction that console issues, control
Magnetic field module processed executes respective scanned sequence.
Illustratively, it includes: that main magnet generates the main magnetic of B0 that MR scanner 520 of the present invention, which generates the detailed process of MR data,
, the intracorporal atomic nucleus of subject generates precession frequency under main field effect, and the precession frequency and main field strength are proportional；
The storage of MR control module and the instruction for sending the scanning sequence (scan sequence) needed to be implemented, pulse-series generator root
Gradient waveform generator and transmitter are controlled according to scanning sequence instruction, gradient waveform generator output has scheduled timing
With the gradient pulse signal of waveform, which passes through Gx, Gy and Gz gradient current amplifier, then passes through three in gradient component
Autonomous channel Gx, Gy, Gz, each gradient amplifier excite a corresponding gradient coil in gradient coil set, generate for giving birth to
At the gradient fields of additional space encoded signal, to carry out space orientation to magnetic resonance signal；Pulse-series generator is also executed and is swept
Sequence is retouched, output includes the timing sum number of the data such as timing, intensity, the shape of radio-frequency pulse of radio-frequency transmissions and radio frequency reception
According to the length of acquisition window to transmitter, while respective radio-frequency pulse is sent to the body transmitting coil in radio frequency unit by transmitter
B1 are generated, the signal that the atomic nucleus being excited in patient body under B1 field action issues is by the receiving coil sense in radio frequency unit
Know, MR data processing module is then transferred to by transmission/reception switch, by the number such as amplification, demodulation, filtering, AD conversion
Wordization processing, is then communicated to MR data memory module.After MR data memory module obtains one group of original k- spatial data,
The end of scan.Original k- spatial data is rearranged into the individual space k- number corresponding with each image that will be reconstructed
According to group, each k- space data set is input into array processor, combines magnetic resonance signal after carrying out image reconstruction, forms one group
Image data.
Four a kind of magnetic resonance imaging system through the embodiment of the present invention realizes under the premise of guaranteeing picture quality,
More rapidly obtain cardiac magnetic resonance images, improve the data acquisition efficiency of magnetic resonance, reduce cardiac magnetic resonance at
It is consumed when picture.
It is total that magnetic provided by any embodiment of the invention can be performed in magnetic resonance imaging system provided by the embodiment of the present invention
Shake imaging method, has the corresponding functional module of execution method and beneficial effect.
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Claims (10)
1. a kind of MR imaging method characterized by comprising
Non- layer choosing inversion pulse is applied to detected object；
In the setting heart movement phase phase in the first cardiac cycle, the multilayer of heart is excited simultaneously using default imaging sequence,
And acquire the multilayer aliasing t1 weighted image of the heart；
In the setting heart movement phase phase in the second cardiac cycle, the default imaging of default flip angle excitation is utilized
Sequence acquisition reference picture；Wherein, first cardiac cycle same single-breath hold corresponding with the second cardiac cycle, and described first
Cardiac cycle and second cardiac cycle are adjacent cardiac cycle, and one layer in the reference picture and the multilayer is opposite
It answers；
The reversion for carrying out interlayer solution aliasing and phase sensitive to the multilayer aliasing t1 weighted image using the reference picture is extensive
It is multiple to rebuild, obtain the target t1 weighted image of each layer of the heart.
2. the method according to claim 1, wherein being weighted using the reference picture to the multilayer aliasing T1
Image carries out interlayer solution aliasing and the inversion recovery of phase sensitive is rebuild, and obtains the target t1 weighted image packet of each layer of the heart
It includes:
Interlayer solution aliasing is carried out to the multilayer aliasing t1 weighted image using the reference picture, obtains the initial T1 weighting of each layer
Image；
It is utilized respectively the inversion recovery that the reference picture carries out phase sensitive to initial t1 weighted image described in every layer to rebuild, obtain
To the target t1 weighted image of each layer of the heart.
3. according to the method described in claim 2, it is characterized in that, being utilized respectively the reference picture to initial T1 described in every layer
The inversion recovery that weighted image carries out phase sensitive is rebuild, and the target t1 weighted image for obtaining each layer of the heart includes:
Plural reference image phase is obtained according to the reference picture；
Using the plural reference image phase, phasing is carried out to initial t1 weighted image described in every layer respectively, is obtained each
Layer real number t1 weighted image；
The reference picture and every layer of real number t1 weighted image are normalized respectively, obtain each layer target
T1 weighted image.
4. the method according to claim 1, wherein the corresponding space K of the multilayer aliasing t1 weighted image is
Lack sampling.
5. according to the method described in claim 4, it is characterized in that, being weighted using the reference picture to the multilayer aliasing T1
Image carries out interlayer solution aliasing and the inversion recovery of phase sensitive is rebuild, and obtains the target t1 weighted image packet of each layer of the heart
It includes:
Interlayer solution aliasing is carried out to the multilayer aliasing t1 weighted image using the reference picture, obtains the initial T1 weighting of each layer
Image；
It is utilized respectively the reference picture initial t1 weighted image described in every layer is carried out to solve aliasing in layer, obtains the space K and adopt entirely
Each layer of sample completely adopts t1 weighted image；
It is utilized respectively the reference picture to rebuild the inversion recovery for completely adopting t1 weighted image progress phase sensitive described in every layer, obtain
To the target t1 weighted image of each layer of the heart.
6. according to the method described in claim 5, it is characterized in that, being utilized respectively the reference picture to completely adopting T1 described in every layer
The inversion recovery that weighted image carries out phase sensitive is rebuild, and the target t1 weighted image for obtaining each layer of the heart includes:
Plural reference image phase is obtained according to the reference picture；
Using the plural reference image phase, respectively to t1 weighted image progress phasing is completely adopted described in every layer, obtain each
Layer real number t1 weighted image；
The reference picture and every layer of real number t1 weighted image are normalized respectively, obtain each layer target
T1 weighted image.
7. method according to claim 2 or 4, which is characterized in that using the reference picture to the multilayer aliasing T1
Weighted image carries out interlayer solution aliasing, and obtaining the initial t1 weighted image of each layer includes:
Using the reference picture, it is based on being layered general self calibration parallel acquisition algorithm or sensitivity encoding and general self calibration simultaneously
Row acquisition unified algorithm, carries out interlayer solution aliasing to the multilayer aliasing t1 weighted image, obtains the initial t1 weighted image of each layer.
8. the method according to claim 1, wherein further include: it is described to hold one's breath comprising multiple, and packet of holding one's breath every time
Containing at least one set of first cardiac cycle and second cardiac cycle, to complete the magnetic resonance imaging to the heart.
9. the method according to claim 1, wherein the default imaging sequence includes quickly damaging gtadient echo
At least one in sequence, spin-echo sequence, gradin-echo, inversion-recovery sequence and the free stable state precession sequence of balance
Kind.
10. a kind of magnetic resonance imaging system characterized by comprising electrocardiograph, MR scanner, and with the electrocardiogram
The processor of machine and MR scanner communication connection；
The electrocardiograph, for generating the ecg-gating signal of detected object；
The processor, is used for:
The MR scanner is triggered according to the ecg-gating signal, and non-layer choosing inversion pulse is applied to detected object；
The MR scanner is controlled in the setting heart movement phase phase in the first cardiac cycle according to the ecg-gating signal,
The multilayer of heart is excited simultaneously using default imaging sequence, and acquires the multilayer aliasing t1 weighted image of the heart；
The setting heart movement phase of the MR scanner in the second cardiac cycle is controlled according to the ecg-gating signal
In phase, the default imaging sequence acquisition reference picture of default flip angle excitation is utilized；Wherein, first cardiac cycle with
Correspond to same single-breath hold the second cardiac cycle, and first cardiac cycle and second cardiac cycle are adjacent week aroused in interest
Phase, the reference picture are corresponding with one layer in the multilayer；
The reversion for carrying out interlayer solution aliasing and phase sensitive to the multilayer aliasing t1 weighted image using the reference picture is extensive
It is multiple to rebuild, obtain the target t1 weighted image of each layer of the heart.
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