CN109498796A - A kind of two-component pharmaceutical composition and the preparation method and application thereof for treating bedsore - Google Patents

A kind of two-component pharmaceutical composition and the preparation method and application thereof for treating bedsore Download PDF

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Publication number
CN109498796A
CN109498796A CN201811461961.7A CN201811461961A CN109498796A CN 109498796 A CN109498796 A CN 109498796A CN 201811461961 A CN201811461961 A CN 201811461961A CN 109498796 A CN109498796 A CN 109498796A
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China
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weight
parts
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bedsore
preparation
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CN201811461961.7A
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Chinese (zh)
Inventor
王海平
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China Merchants State Incubator Group Ltd
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China Merchants State Incubator Group Ltd
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Priority to CN201811461961.7A priority Critical patent/CN109498796A/en
Publication of CN109498796A publication Critical patent/CN109498796A/en
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract

The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of two-component pharmaceutical composition and the preparation method and application thereof for treating bedsore.The two-component pharmaceutical preparation for the treatment of bedsore of the present invention, the mode being used in combination by using the second pharmaceutical preparation that the first pharmaceutical preparation and ulcer in previous tretament ulcer use more afterwards, give full play to the pharmacological property of each component, using each ingredient drug effect monarch, minister, help, be allowed between effective cooperation, the effect of playing its clear hemostasis, relieving heat toxin altogether, there is preferable therapeutic effect for each course of disease bedsore, and safety is without any side effects.

Description

A kind of two-component pharmaceutical composition and the preparation method and application thereof for treating bedsore
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of two-component pharmaceutical composition for treating bedsore and its Preparation method and application.
Background technique
Bedsore, also known as pressure sore or pressure ulcer are since local organization is pressurized for a long time to lead to that blood circulation barrier occurs Hinder, and local organization continuous ischemia, anoxic, malnutrition, skin is caused to lose normal function, and causes tissue fester's necrosis Complication is a kind of clinically common complication.Especially old and frail, prolonged illness bed, stupor, the patient to paralyse, because of length Phase bed, local skin are acted on cuticula easy to damage, while continuous compression blood circulation disorder by frictional force, cause hypoxic-ischemic Exanthemv forms ulcer.Clinically, since wound, fracture, traffic accident, mine disaster, geological disaster and brain paralysis, paralytic patient constantly increase More, secondary patients with bedsore also accordingly increases, so that the problem of pressure ulcer becomes a universality in rehabilitation, nursing. It is such as not treated in time, can not be cured for a long time, patient pain is unbearably or ulcer surface expands and deepens, and Yi Yinqi septicemia and jeopardizes trouble Person's life.
Bedsore mostly occurs in bone protrusion compression position, is occurred, development process can be divided into three degree according to it: being once part It is showed only as erythema oedema or pale asphyxia, cinerous, boundary understands, there is feeling of numbness or tenderness, it, can be in a couple of days if processing in time Interior improvement；Two degree are that skin color is darkviolet or atropurpureus, may occur in which blister, form superficial erosion face after the rupture of blister wall；Three Degree is formed for ulcer, and shallow person reaches subcutaneous tissue, and for deep person up to bone tissue, fester is more after secondary infection, and has stink.Due to bedsore For non-primary illness, physicians are classified as bedsore the branch at disease edge, fail to cause enough attention, infect bedsore Less than stringent control, and bedsore occurs again less than quick treatment, causes bedsore infection to have become various big hospital most intractable Problem, according to related document report, there are about 60,000 people to die of pressure sore concomitant symptoms every year.
Now clinically, treatment bedsore is generally in such a way that drug therapy and nursing combine, at present mostly using such as Bedsore is treated in the externally applied drugs such as Shengji San, but the epidermis in bedsore affected part can tie cangue after external drug medicine-feeding, but below the epidermis is festered Part can not but cure completely, can also make drug that can not reach the below the epidermis of knot cangue, and pus is more than after often resulting in incrustation. Deeper patient is infected for bedsore, the therapeutic effect of existing common external drug can be worse.
Summary of the invention
For this purpose, technical problem to be solved by the present invention lies in a kind of two-component pharmaceutical composition for treating bedsore is provided, It is ineffective to solve the problems, such as to treat patients with decubitus in the prior art.
In order to solve the above technical problems, a kind of two-component pharmaceutical composition for treating bedsore of the present invention, including it is preceding The second pharmaceutical composition that the first pharmaceutical composition and ulcer of phase treatment ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of first pharmaceutical composition includes: root of fangji 25-35 parts by weight, dragon's blood 4-8 parts by weight, Chuan Shan Imperial 15-25 parts by weight, monkshood 10-15 parts by weight, radix cyathulae 10-15 parts by weight, corydalis tuber 15-25 parts by weight, Paris polyphylla 25-35 weight Part, safflower 8-12 parts by weight, lopseed 8-12 parts by weight, lycopodium calvatum 15-25 parts by weight, pericarpium zanthoxyli 8-12 parts by weight, Hedyotidis Diffusae 8-12 parts by weight, Radix Angelicae Pubescentis 15-25 parts by weight, caulis trachelospermi 15-25 parts by weight, caulis piperis futokadsurae 15-25 parts by weight, radix saposhnikoviae 8-12 weight Part, Radix Salviae Miltiorrhizae 15-20 parts by weight, bush 10-15 parts by weight, olibanum 1-3 parts by weight, myrrh 1-3 parts by weight, the first insect protein 3.5-4 parts by weight；
The bulk pharmaceutical chemicals composition of second pharmaceutical composition includes: folium isatidis 15-25 parts by weight, Radix Isatidis 10-15 weight Part, Radix Paeoniae Alba 25-35 parts by weight, setose thistle 25-35 parts by weight, larva of a silkworm with batrytis 10-15 parts by weight, root of Dahurain angelica 25-35 parts by weight, rhizoma ligustici 10- 15 parts by weight, coptis 10-15 parts by weight, frutus cnidii 25-35 parts by weight, borneol 15-25 parts by weight, Radix Notoginseng 15-25 parts by weight, Chinese mugwort Leaf 15-25 parts by weight, peppermint 25-35 parts by weight, honeysuckle 25-35 parts by weight, Radix Angelicae Sinensis 8-12 parts by weight, wrinkled giant hyssop 15-25 weight Part, chrysanthemum 8-12 parts by weight, lotus 10-15 parts by weight, Sculellaria barbata 15-25 parts by weight, the second insect protein 3.5-4 parts by weight.
Preferably, in the two-component pharmaceutical composition of the treatment bedsore:
The bulk pharmaceutical chemicals composition of first pharmaceutical composition includes: 30 parts by weight of the root of fangji, 6 parts by weight of dragon's blood, rhizoma dioscoreae nipponicae 20 Parts by weight, 12 parts by weight of monkshood, 12 parts by weight of radix cyathulae, 20 parts by weight of corydalis tuber, 30 parts by weight of Paris polyphylla, 10 parts by weight of safflower, thoroughly Bone grass 10 parts by weight, 20 parts by weight of lycopodium calvatum, 10 parts by weight of pericarpium zanthoxyli, 10 parts by weight of Hedyotidis Diffusae, 20 parts by weight of Radix Angelicae Pubescentis, caulis trachelospermi 20 parts by weight, 20 parts by weight of caulis piperis futokadsurae, windproof 10 parts by weight, 18 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of bush, 12 parts by weight of centipede, 2 parts by weight of olibanum, 2 parts by weight of myrrh, 3.8 parts by weight of the first insect protein；
The bulk pharmaceutical chemicals composition of second pharmaceutical composition includes: 20 parts by weight of folium isatidis, 12 parts by weight of Radix Isatidis, Radix Paeoniae Alba 30 parts by weight, 30 parts by weight of setose thistle, 12 parts by weight of the larva of a silkworm with batrytis, 30 parts by weight of the root of Dahurain angelica, 12 parts by weight of rhizoma ligustici, 12 parts by weight of the coptis, 30 parts by weight of frutus cnidii, 20 parts by weight of borneol, 20 parts by weight of Radix Notoginseng, 20 parts by weight of folium artemisiae argyi, 30 parts by weight of peppermint, 30 weight of honeysuckle Measure part, 10 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of wrinkled giant hyssop, 10 parts by weight of chrysanthemum, 12 parts by weight of lotus, 20 parts by weight of Sculellaria barbata, insect 3.8 parts by weight of albumen.
Specifically, the two-component pharmaceutical composition of the treatment bedsore:
First insect protein is to carry out water as raw material using the dried venom of toads, scorpio, centipede to obtain through refining；
Second insect protein is to carry out water as raw material using the dried venom of toads, scorpio, gecko to obtain through refining.
Preferably, the two-component pharmaceutical composition of the treatment bedsore:
In first insect protein, the dried venom of toads, scorpio, centipede mass ratio be 1:2:3；
In second insect protein, the dried venom of toads, scorpio, gecko mass ratio be 1:2:3.
The invention also discloses the purposes that the pharmaceutical composition is used to prepare the two-component pharmaceutical preparation for the treatment of bedsore.
The invention also discloses by the pharmaceutical composition, customary adjuvant is added, according to clinic made from common process The two-component external medicine preparation of upper acceptable treatment bedsore.
The two-component external medicine preparation of the treatment bedsore, the first pharmaceutical preparation including previous tretament ulcer and bursts The second pharmaceutical preparation that ulcer uses more afterwards；
First pharmaceutical preparation, second pharmaceutical preparation include spray, drops, liniment, paste and/or paint.
The invention also discloses a kind of methods of two-component external medicine preparation for preparing the treatment bedsore, including system The step of standby first pharmaceutical preparation and the step of preparing the second pharmaceutical preparation:
The preparation method of first pharmaceutical preparation, includes the following steps:
(1) take a selected amount of root of fangji, dragon's blood, rhizoma dioscoreae nipponicae, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, Lycopodium calvatum, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, olibanum, myrrh, and respectively plus water into Row is impregnated and is boiled, and is collected filtrate and is concentrated, obtains Chinese medical extract, spare；
(2) take a selected amount of dried venom of toads, scorpio and centipede be raw material, add water to extract, collect filtrate it is chilled and After freeze-drying, freeze-dried powder is made, it is spare；
(3) gained Chinese medical extract and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, according to Clinically acceptable external preparation is made in common process；
The preparation method of the second pharmaceutical preparation, includes the following steps:
(1 ') takes a selected amount of folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, cnidium monnieri Son, borneol, Radix Notoginseng, folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata, and add water to be impregnated simultaneously respectively Tanning obtains Chinese medical extract after collecting filtrate and being concentrated, spare；
(2 ') take a selected amount of dried venom of toads, scorpio and gecko be raw material, add water to extract, collect filtrate it is chilled and After freeze-drying, freeze-dried powder is made, it is spare；
(3 ') mix gained Chinese medical extract and a selected amount of insect protein freeze-dried powder, and customary adjuvant is added, presses Clinically acceptable external preparation is made in more solito technique.
Preferably, in the step (1) and/or the step (1 '), the soaking step time is 30-60min.
More preferably, the method for the two-component external medicine preparation for preparing the treatment bedsore:
In the step (1), the dragon's blood, monkshood, radix cyathulae, pericarpium zanthoxyli, Radix Angelicae Pubescentis, radix saposhnikoviae, Radix Salviae Miltiorrhizae, olibanum, myrrh are endured Time processed is 45min；The root of fangji, rhizoma dioscoreae nipponicae, Paris polyphylla, lycopodium calvatum, Hedyotidis Diffusae, caulis piperis futokadsurae, bush the tanning time be 40min；The corydalis tuber, safflower, lopseed, caulis trachelospermi the tanning time be 20min；
In the step (1 '), the Radix Paeoniae Alba, setose thistle, rhizoma ligustici, frutus cnidii, borneol, Radix Angelicae Sinensis the tanning time be 45min； The folium isatidis, Radix Isatidis, the larva of a silkworm with batrytis, the coptis, Radix Notoginseng, folium artemisiae argyi, peppermint the tanning time be 40min；The root of Dahurain angelica, gold and silver Spend, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata the tanning time be 20min.
Preferably, in the step (1) and/or the step (1 '), further include be added in the Chinese medical extract it is white The step of wine and/or potassium sorbate.
More preferably, the additional amount of the white wine accounts for the 5wt% of each raw material total amount, and the additional amount of the potassium sorbate accounts for The 0.3wt% of each raw material total amount.
The two-component pharmaceutical preparation for the treatment of bedsore of the present invention, by using in the first drug system of previous tretament ulcer The mode that the second pharmaceutical preparation that agent and ulcer use more afterwards is used in combination, first pharmaceutical preparation is with the root of fangji, dragon's blood, Chuan Shan Dragon, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, lycopodium calvatum, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, Radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, centipede, olibanum, myrrh are raw material, and extract insect protein using the dried venom of toads, scorpio, centipede as raw material；It is described Second pharmaceutical preparation with folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, frutus cnidii, borneol, Radix Notoginseng, Folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata are traditional Chinese medicinal components, and are original with the dried venom of toads, scorpio, gecko Material extracts insect protein；First pharmaceutical preparation and second pharmaceutical preparation are respectively used to previous tretament ulcer and ulcer and consolidate more afterwards Gu give full play to the pharmacological property of each component, using each ingredient drug effect monarch, minister, help, be allowed between effective cooperation, play altogether its clear hemostasis, The effect of relieving heat toxin, has preferable therapeutic effect to bedsore.And the two-component pharmaceutical preparation for the treatment of bedsore of the present invention, Under the collective effect that previous tretament ulcer and ulcer are consolidated more afterwards, there is preferable therapeutic effect for each course of disease bedsore, and pacify It is complete without any side effects.
Specific embodiment
Embodiment 1
The two-component pharmaceutical preparation that bedsore is treated described in the present embodiment, is included in the first bioprotein of previous tretament ulcer The second bioprotein spray that spray and ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of the first bioprotein spray includes: root of fangji 25kg, dragon's blood 8kg, rhizoma dioscoreae nipponicae 15kg, monkshood 15kg, radix cyathulae 10kg, corydalis tuber 25kg, Paris polyphylla 25kg, safflower 12kg, lopseed 8kg, lycopodium calvatum 25kg, pericarpium zanthoxyli 8kg, white flower Snakeweed 12kg, Radix Angelicae Pubescentis 15kg, caulis trachelospermi 25kg, caulis piperis futokadsurae 15kg, radix saposhnikoviae 12kg, Radix Salviae Miltiorrhizae 15kg, bush 15kg, olibanum 3kg, do not have Medicine 1kg, the first insect protein 4kg；
The second bioprotein spray bulk pharmaceutical chemicals composition include: folium isatidis 15kg, Radix Isatidis 15kg, Radix Paeoniae Alba 25kg, Setose thistle 35kg, larva of a silkworm with batrytis 10kg, root of Dahurain angelica 35kg, rhizoma ligustici 10kg, coptis 15kg, frutus cnidii 25kg, borneol 25kg, Radix Notoginseng 15kg, Folium artemisiae argyi 25kg, peppermint 25kg, honeysuckle 35kg, Radix Angelicae Sinensis 8kg, wrinkled giant hyssop 25kg, chrysanthemum 8kg, lotus 15kg, Sculellaria barbata 15kg, Two insect protein 4kg.
The preparation method of the two-component pharmaceutical preparation of bedsore is treated described in the present embodiment, including prepares the described first biological egg The step of white spray and the step of preparing the second bioprotein spray, wherein
The preparation method of the first bioprotein spray, includes the following steps:
(1) take a selected amount of root of fangji, dragon's blood, rhizoma dioscoreae nipponicae, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, Lycopodium calvatum, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, olibanum, myrrh, and respectively plus water into Row impregnates 30-60min；Then by after immersion the dragon's blood, monkshood, radix cyathulae, pericarpium zanthoxyli, Radix Angelicae Pubescentis, radix saposhnikoviae, Radix Salviae Miltiorrhizae, olibanum, do not have It is 45min that medicine, which carries out tanning,；By the root of fangji after immersion, rhizoma dioscoreae nipponicae, Paris polyphylla, lycopodium calvatum, Hedyotidis Diffusae, caulis piperis futokadsurae, bush Carry out tanning 40min；The corydalis tuber after immersion, safflower, lopseed, caulis trachelospermi are subjected to tanning 20min；Collect above-mentioned tanning After filtrate afterwards mixes and is concentrated, and white wine (5wt% of Zhan Suoyou raw material total amount) is added and potassium sorbate (accounts for all originals Expect the 0.3wt% of total amount) it mixes, Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
(2) taking the gecko, the dried venom of toads, centipede according to the mass ratio of 1:2:3 is raw material, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 2 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3) gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, according to Common process is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray save one under room temperature Year, 2-3 is saved at 10 DEG C；
The preparation method of the second bioprotein spray, includes the following steps:
(1 ') takes a selected amount of folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, cnidium monnieri Son, borneol, Radix Notoginseng, folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata, and add water to be impregnated respectively 30-60min；The Radix Paeoniae Alba after immersion, setose thistle, rhizoma ligustici, frutus cnidii, borneol, Radix Angelicae Sinensis are then subjected to tanning 45min；It will leaching The folium isatidis, Radix Isatidis, the larva of a silkworm with batrytis, the coptis, Radix Notoginseng, folium artemisiae argyi, peppermint after bubble carry out tanning 40min；By the institute after immersion It states the root of Dahurain angelica, honeysuckle, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata and carries out tanning 20min；Filtrate mixing after collecting above-mentioned tanning is gone forward side by side After row concentration, appropriate Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
It is raw material that (2 '), which take the gecko, the dried venom of toads, gecko according to the mass ratio of 1:2:3, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 2 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3 ') mix gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder, and customary adjuvant is added, presses More solito technique is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray saved under room temperature 1 year, 2-3 is saved at 10 DEG C.
Embodiment 2
The two-component pharmaceutical preparation that bedsore is treated described in the present embodiment, is included in the first bioprotein of previous tretament ulcer The second bioprotein spray that spray and ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of the first bioprotein spray includes: root of fangji 35kg, dragon's blood 4kg, rhizoma dioscoreae nipponicae 25kg, monkshood 10kg, radix cyathulae 15kg, corydalis tuber 15kg, Paris polyphylla 35kg, safflower 8kg, lopseed 12kg, lycopodium calvatum 15kg, pericarpium zanthoxyli 12kg, white flower Snakeweed 8kg, Radix Angelicae Pubescentis 25kg, caulis trachelospermi 15kg, caulis piperis futokadsurae 25kg, radix saposhnikoviae 8kg, Radix Salviae Miltiorrhizae 20kg, bush 10kg, olibanum 1kg, myrrh 3kg, the first insect protein 3.5kg；
The second bioprotein spray bulk pharmaceutical chemicals composition include: folium isatidis 25kg, Radix Isatidis 10kg, Radix Paeoniae Alba 35kg, Setose thistle 25kg, larva of a silkworm with batrytis 15kg, root of Dahurain angelica 25kg, rhizoma ligustici 15kg, coptis 10kg, frutus cnidii 35kg, borneol 15kg, Radix Notoginseng 25kg, Folium artemisiae argyi 15kg, peppermint 35kg, honeysuckle 25kg, Radix Angelicae Sinensis 12kg, wrinkled giant hyssop 15kg, chrysanthemum 12kg, lotus 10kg, Sculellaria barbata 25kg, Insect protein 3.5kg.
The preparation method of the two-component pharmaceutical preparation of bedsore is treated described in the present embodiment, including prepares the described first biological egg The step of white spray and the step of preparing the second bioprotein spray, wherein
The preparation method of the first bioprotein spray, includes the following steps:
(1) take a selected amount of root of fangji, dragon's blood, rhizoma dioscoreae nipponicae, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, Lycopodium calvatum, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, olibanum, myrrh, and respectively plus water into Row impregnates 30-60min；Then by after immersion the dragon's blood, monkshood, radix cyathulae, pericarpium zanthoxyli, Radix Angelicae Pubescentis, radix saposhnikoviae, Radix Salviae Miltiorrhizae, olibanum, do not have It is 45min that medicine, which carries out tanning,；By the root of fangji after immersion, rhizoma dioscoreae nipponicae, Paris polyphylla, lycopodium calvatum, Hedyotidis Diffusae, caulis piperis futokadsurae, bush Carry out tanning 40min；The corydalis tuber after immersion, safflower, lopseed, caulis trachelospermi are subjected to tanning 20min；Collect above-mentioned tanning After filtrate afterwards mixes and is concentrated, and white wine (5wt% of Zhan Suoyou raw material total amount) is added and potassium sorbate (accounts for all originals Expect the 0.3wt% of total amount) it mixes, Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
(2) taking the gecko, the dried venom of toads, centipede according to the mass ratio of 1:2:3 is raw material, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 4 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3) gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, according to Common process is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray save one under room temperature Year, 2-3 is saved at 10 DEG C；
The preparation method of the second bioprotein spray, includes the following steps:
(1 ') takes a selected amount of folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, cnidium monnieri Son, borneol, Radix Notoginseng, folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata, and add water to be impregnated respectively 30-60min；The Radix Paeoniae Alba after immersion, setose thistle, rhizoma ligustici, frutus cnidii, borneol, Radix Angelicae Sinensis are then subjected to tanning 45min；It will leaching The folium isatidis, Radix Isatidis, the larva of a silkworm with batrytis, the coptis, Radix Notoginseng, folium artemisiae argyi, peppermint after bubble carry out tanning 40min；By the institute after immersion It states the root of Dahurain angelica, honeysuckle, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata and carries out tanning 20min；Filtrate mixing after collecting above-mentioned tanning is gone forward side by side After row concentration, appropriate Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
It is raw material that (2 '), which take the gecko, the dried venom of toads, gecko according to the mass ratio of 1:2:3, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 4 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3 ') mix gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder, and customary adjuvant is added, presses More solito technique is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray saved under room temperature 1 year, 2-3 is saved at 10 DEG C.
Embodiment 3
The two-component pharmaceutical preparation that bedsore is treated described in the present embodiment, is included in the first bioprotein of previous tretament ulcer The second bioprotein spray that spray and ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of the first bioprotein spray includes: root of fangji 30kg, dragon's blood 6kg, rhizoma dioscoreae nipponicae 20kg, monkshood It is 12kg, radix cyathulae 12kg, corydalis tuber 20kg, Paris polyphylla 30kg, safflower 10kg, lopseed 10kg, lycopodium calvatum 20kg, pericarpium zanthoxyli 10kg, white Flower snakeweed 10kg, Radix Angelicae Pubescentis 20kg, caulis trachelospermi 20kg, caulis piperis futokadsurae 20kg, radix saposhnikoviae 10kg, Radix Salviae Miltiorrhizae 18kg, bush 12kg, olibanum 2kg, Myrrh 2kg, the first insect protein 3.8kg；
The second bioprotein spray bulk pharmaceutical chemicals composition include: folium isatidis 20kg, Radix Isatidis 12kg, Radix Paeoniae Alba 30kg, Setose thistle 30kg, larva of a silkworm with batrytis 12kg, root of Dahurain angelica 30kg, rhizoma ligustici 12kg, coptis 12kg, frutus cnidii 30kg, borneol 20kg, Radix Notoginseng 20kg, Folium artemisiae argyi 20kg, peppermint 30kg, honeysuckle 30kg, Radix Angelicae Sinensis 10kg, wrinkled giant hyssop 20kg, chrysanthemum 10kg, lotus 12kg, Sculellaria barbata 20kg, Second insect protein 3.8kg.
The preparation method of the two-component pharmaceutical preparation of bedsore is treated described in the present embodiment, including prepares the described first biological egg The step of white spray and the step of preparing the second bioprotein spray, wherein
The preparation method of the first bioprotein spray, includes the following steps:
(1) take a selected amount of root of fangji, dragon's blood, rhizoma dioscoreae nipponicae, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, Lycopodium calvatum, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, olibanum, myrrh, and respectively plus water into Row impregnates 30-60min；Then by after immersion the dragon's blood, monkshood, radix cyathulae, pericarpium zanthoxyli, Radix Angelicae Pubescentis, radix saposhnikoviae, Radix Salviae Miltiorrhizae, olibanum, do not have It is 45min that medicine, which carries out tanning,；By the root of fangji after immersion, rhizoma dioscoreae nipponicae, Paris polyphylla, lycopodium calvatum, Hedyotidis Diffusae, caulis piperis futokadsurae, bush Carry out tanning 40min；The corydalis tuber after immersion, safflower, lopseed, caulis trachelospermi are subjected to tanning 20min；Collect above-mentioned tanning After filtrate afterwards mixes and is concentrated, and white wine (5wt% of Zhan Suoyou raw material total amount) is added and potassium sorbate (accounts for all originals Expect the 0.3wt% of total amount) it mixes, Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
(2) taking the gecko, the dried venom of toads, centipede according to the mass ratio of 1:2:3 is raw material, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 3 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3) gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, according to Common process is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray save one under room temperature Year, 2-3 is saved at 10 DEG C；
The preparation method of the second bioprotein spray, includes the following steps:
(1 ') takes a selected amount of folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, cnidium monnieri Son, borneol, Radix Notoginseng, folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata, and add water to be impregnated respectively 30-60min；The Radix Paeoniae Alba after immersion, setose thistle, rhizoma ligustici, frutus cnidii, borneol, Radix Angelicae Sinensis are then subjected to tanning 45min；It will leaching The folium isatidis, Radix Isatidis, the larva of a silkworm with batrytis, the coptis, Radix Notoginseng, folium artemisiae argyi, peppermint after bubble carry out tanning 40min；By the institute after immersion It states the root of Dahurain angelica, honeysuckle, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata and carries out tanning 20min；Filtrate mixing after collecting above-mentioned tanning is gone forward side by side After row concentration, appropriate Chinese medicine extract is obtained, and carry out stablizing 48h, it is spare；
It is raw material that (2 '), which take the gecko, the dried venom of toads, gecko according to the mass ratio of 1:2:3, after being routinely sieved and removing dust, It is mixed and added into and accounts for the water of 3 times of insect raw material total amount amounts and carry out decoction extraction, collect filtrate after being centrifuged 10-30min, freezed 4h then carries out freeze-drying 6h, and insect protein freeze-dried powder is made, and saves in -30 DEG C, spare；
(3 ') mix gained Chinese medicine extract and a selected amount of insect protein freeze-dried powder, and customary adjuvant is added, presses More solito technique is made clinically acceptable bioprotein spray, it is filling after refined biometric albumen spray saved under room temperature 1 year, 2-3 is saved at 10 DEG C.
Embodiment 4
The two-component pharmaceutical preparation that bedsore is treated described in the present embodiment, is included in the first bioprotein of previous tretament ulcer The second bioprotein paste that paste and ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of the first bioprotein paste includes: root of fangji 28kg, dragon's blood 7kg, rhizoma dioscoreae nipponicae 18kg, monkshood 13kg, radix cyathulae 11kg, corydalis tuber 22kg, Paris polyphylla 28kg, safflower 11kg, lopseed 9kg, lycopodium calvatum 22kg, pericarpium zanthoxyli 9kg, white flower Snakeweed 11kg, Radix Angelicae Pubescentis 18kg, caulis trachelospermi 22kg, caulis piperis futokadsurae 18kg, radix saposhnikoviae 11kg, Radix Salviae Miltiorrhizae 16kg, bush 13kg, olibanum 2.5kg, Myrrh 1.5kg, the first insect protein 3.9kg；
The second bioprotein paste bulk pharmaceutical chemicals composition include: folium isatidis 18kg, Radix Isatidis 13kg, Radix Paeoniae Alba 28kg, Setose thistle 32kg, larva of a silkworm with batrytis 11kg, root of Dahurain angelica 32kg, rhizoma ligustici 11kg, coptis 14kg, frutus cnidii 28kg, borneol 22kg, Radix Notoginseng 18kg, Folium artemisiae argyi 22kg, peppermint 28kg, honeysuckle 32kg, Radix Angelicae Sinensis 9kg, wrinkled giant hyssop 22kg, chrysanthemum 9kg, lotus 13kg, Sculellaria barbata 18kg, Two insect protein 3.9kg.
The preparation method of the two-component pharmaceutical preparation of bedsore is treated described in the present embodiment with embodiment 3.
Embodiment 5
The two-component pharmaceutical preparation that bedsore is treated described in the present embodiment, is included in the first bioprotein of previous tretament ulcer The second bioprotein spray that spray and ulcer use more afterwards:
The bulk pharmaceutical chemicals composition of the first bioprotein spray includes: root of fangji 32kg, dragon's blood 5kg, rhizoma dioscoreae nipponicae 22kg, monkshood 11kg, radix cyathulae 14kg, corydalis tuber 18kg, Paris polyphylla 32kg, safflower 9kg, lopseed 11kg, lycopodium calvatum 18kg, pericarpium zanthoxyli 11kg, white flower Snakeweed 9kg, Radix Angelicae Pubescentis 22kg, caulis trachelospermi 18kg, caulis piperis futokadsurae 22kg, radix saposhnikoviae 9kg, Radix Salviae Miltiorrhizae 19kg, bush 11kg, olibanum 1.5kg, do not have Medicine 2.5kg, the first insect protein 3.6kg；
The second bioprotein spray bulk pharmaceutical chemicals composition include: folium isatidis 22kg, Radix Isatidis 11kg, Radix Paeoniae Alba 32kg, Setose thistle 28kg, larva of a silkworm with batrytis 14kg, root of Dahurain angelica 28kg, rhizoma ligustici 13kg, coptis 11kg, frutus cnidii 32kg, borneol 18kg, Radix Notoginseng 22kg, Folium artemisiae argyi 18kg, peppermint 32kg, honeysuckle 28kg, Radix Angelicae Sinensis 11kg, wrinkled giant hyssop 18kg, chrysanthemum 11kg, lotus 11kg, Sculellaria barbata 22kg, Second insect protein 3.6kg.
The preparation method of the two-component pharmaceutical preparation of bedsore is treated described in the present embodiment with embodiment 3.
Experimental example
1, example is treated
Clinic is collected because the various causes of disease suffer from 35 progress clinical observations of patient of bedsore, and patient age was between 25-70 years old And normal distribution is presented, men and women patient populations are of substantially equal；In above-mentioned patient, severe bedsore patient 10, moderate patients with bedsore 16, slight patients with bedsore 9, clinical bedsore standard is as follows:
Severe bedsore: the infection of bedsore epidermis blister ulceration, infection rear surface have dope covering, cause shallow layer tissue downright bad, Ulcer is formed, and the pain increased；
Moderate bedsore: bedsore epidermis blister ulceration exposes moist ruddy sore face, there is the covering of yellow diffusate；
Slight bedsore: bedsore epidermis has blister to be formed.
Medication: two-component spray prepared by Example 3 is sprayed with the first bioprotein spray at treatment initial stage and is suffered from Place after incrustation healing at ulcer, changes 3 times a day and sprays affected part with the second bioprotein spray, 3 times a day.
The evaluation criterion of clinical therapeutic efficacy are as follows:
Cure: bedsore face is dry, has new granulation tissue to grow, inwardly gradually forms incrustation from bedsore periphery；
Effective: 35 days bedsore face diffusates of medication, secretion and concentrated secretion are reduced, and bedsore face is dry, medication 6-7 Tian You new granulation tissue grows, and bedsore periphery has incrustation to be formed；
Invalid: bedsore face still has secretion and concentrated secretion to generate after medication 7 days, and bedsore face has necrotic tissue to be formed, Patient pain's aggravation.
The two-component spray combination therapy prepared using the embodiment of the present invention 3, observes the treatment knot of the bedsore of 35 patients Fruit is recorded in the following table 1.
1 clinical treatment outcome of table
But in fact, it should be noted that incrustation only completes just for the treatment of bedsore in clinical test The therapeutic effect of step, after many bedsore preparations are formed a scab in affected part, the part of festering of below the epidermis can not but cure completely, lead Bedsore recurrent exerbation is caused, and incrustation is not easy voluntarily to fall off.
During above-mentioned experimental example of the invention carries out, 35 whole patients are controlled using the first bioprotein spray After treatment, the incrustation (realizing the healing in above-mentioned standard) in affected part is realized faster, still, does not use institute if discontinuing medication The second bioprotein spray is stated, then finds that still there is the below the epidermis in affected part to have the problem of festering, and incrustation is difficult voluntarily to take off It falls, continues to use the first bioprotein spray at this time and have no further curative effect.
In clinical test, the second bioprotein spray is continued to use to above-mentioned drug withdrawal patient, then in the biological egg Under the action of white spray, drug will continue to infiltrate into affected part, the incrustation of all different degrees of patients with bedsore in clinical test Voluntarily to fall off in a short time, and illing skin is completely recovered.Specific experiment situation see the table below 2.
1 clinical treatment outcome of table
As it can be seen that the two-component preparation for the treatment of bedsore of the present invention, first biologic protein agents facilitate bedsore trouble Place's quickly incrustation healing, and lasting infiltration is carried out to the affected part after incrustation under the action of second biologic protein agents, Facilitate the fast-falling of incrustation and the complete healing in affected part.2, typical case
1, it is military certain, male, 48 one full year of life of age, because of serious accident clinotherapy 3 months, there is bedsore in bottom tail portion, scapular region Symptom, blister ulceration expose moist ruddy sore face.It is treated using two-component preparation in the embodiment of the present invention 3, medication 2 days Affected part is formed a scab, and is continued to use the second albumen spray 3 days, is voluntarily fallen off completely at incrustation, affected part is healed completely.
2, it is pungent certain, female 80 years old, lies in bed throughout the year, and large area bedsore occur in back, buttocks, and shallow layer tissue's necrosis is presented and burst Ulcer symptom belongs to severe bedsore patient.It is treated using two-component preparation in the embodiment of the present invention 3,4 days affected parts of medication are tied Scab, continues to use the second albumen spray 4 days, voluntarily falls off completely at incrustation, affected part is healed completely.
To sum up, the two-component pharmaceutical preparation for the treatment of bedsore of the present invention is treating different degrees of decubitus symptom with aobvious The therapeutic effect of work, and treatment cycle is shorter, clinical use is without any side effects.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or It changes still within the protection scope of the invention.

Claims (10)

1. a kind of two-component pharmaceutical composition for treating bedsore, the first pharmaceutical composition and ulcer including previous tretament ulcer are cured The second pharmaceutical composition used afterwards, it is characterised in that:
The bulk pharmaceutical chemicals composition of first pharmaceutical composition includes: root of fangji 25-35 parts by weight, dragon's blood 4-8 parts by weight, rhizoma dioscoreae nipponicae 15-25 parts by weight, monkshood 10-15 parts by weight, radix cyathulae 10-15 parts by weight, corydalis tuber 15-25 parts by weight, Paris polyphylla 25-35 weight Part, safflower 8-12 parts by weight, lopseed 8-12 parts by weight, lycopodium calvatum 15-25 parts by weight, pericarpium zanthoxyli 8-12 parts by weight, Hedyotidis Diffusae 8-12 parts by weight, Radix Angelicae Pubescentis 15-25 parts by weight, caulis trachelospermi 15-25 parts by weight, caulis piperis futokadsurae 15-25 parts by weight, radix saposhnikoviae 8-12 weight Part, Radix Salviae Miltiorrhizae 15-20 parts by weight, bush 10-15 parts by weight, olibanum 1-3 parts by weight, myrrh 1-3 parts by weight, the first insect protein 3.5-4 parts by weight；
The bulk pharmaceutical chemicals composition of second pharmaceutical composition includes: folium isatidis 15-25 parts by weight, Radix Isatidis 10-15 parts by weight, white Chinese herbaceous peony 25-35 parts by weight, setose thistle 25-35 parts by weight, larva of a silkworm with batrytis 10-15 parts by weight, root of Dahurain angelica 25-35 parts by weight, rhizoma ligustici 10-15 weight Part, coptis 10-15 parts by weight, frutus cnidii 25-35 parts by weight, borneol 15-25 parts by weight, Radix Notoginseng 15-25 parts by weight, folium artemisiae argyi 15- 25 parts by weight, peppermint 25-35 parts by weight, honeysuckle 25-35 parts by weight, Radix Angelicae Sinensis 8-12 parts by weight, wrinkled giant hyssop 15-25 parts by weight, chrysanthemum Flower 8-12 parts by weight, lotus 10-15 parts by weight, Sculellaria barbata 15-25 parts by weight, the second insect protein 3.5-4 parts by weight.
2. the two-component pharmaceutical composition for the treatment of bedsore according to claim 1, it is characterised in that:
The bulk pharmaceutical chemicals composition of first pharmaceutical composition includes: 30 parts by weight of the root of fangji, 6 parts by weight of dragon's blood, 20 weight of rhizoma dioscoreae nipponicae Part, 12 parts by weight of monkshood, 12 parts by weight of radix cyathulae, 20 parts by weight of corydalis tuber, 30 parts by weight of Paris polyphylla, 10 parts by weight of safflower, lopseed 10 parts by weight, 20 parts by weight of lycopodium calvatum, 10 parts by weight of pericarpium zanthoxyli, 10 parts by weight of Hedyotidis Diffusae, 20 parts by weight of Radix Angelicae Pubescentis, 20 weight of caulis trachelospermi Measure part, 20 parts by weight of caulis piperis futokadsurae, windproof 10 parts by weight, 18 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of bush, 12 parts by weight of centipede, olibanum 2 Parts by weight, 2 parts by weight of myrrh, 3.8 parts by weight of the first insect protein；
The bulk pharmaceutical chemicals composition of second pharmaceutical composition includes: 20 parts by weight of folium isatidis, 12 parts by weight of Radix Isatidis, 30 weight of Radix Paeoniae Alba Measure part, 30 parts by weight of setose thistle, 12 parts by weight of the larva of a silkworm with batrytis, 30 parts by weight of the root of Dahurain angelica, 12 parts by weight of rhizoma ligustici, 12 parts by weight of the coptis, cnidium monnieri Sub 30 parts by weight, 20 parts by weight of borneol, 20 parts by weight of Radix Notoginseng, 20 parts by weight of folium artemisiae argyi, 30 parts by weight of peppermint, 30 weight of honeysuckle Part, 10 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of wrinkled giant hyssop, 10 parts by weight of chrysanthemum, 12 parts by weight of lotus, 20 parts by weight of Sculellaria barbata, insect egg White 3.8 parts by weight.
3. the two-component pharmaceutical composition for the treatment of bedsore according to claim 1 or 2, it is characterised in that:
First insect protein is to carry out water as raw material using the dried venom of toads, scorpio, centipede to obtain through refining；
Second insect protein is to carry out water as raw material using the dried venom of toads, scorpio, gecko to obtain through refining.
4. the two-component pharmaceutical composition for the treatment of bedsore according to claim 3, it is characterised in that:
In first insect protein, the dried venom of toads, scorpio, centipede mass ratio be 1:2:3；
In second insect protein, the dried venom of toads, scorpio, gecko mass ratio be 1:2:3.
5. the use that the described in any item pharmaceutical compositions of claim 1-4 are used to prepare the two-component pharmaceutical preparation for the treatment of bedsore On the way.
6. customary adjuvant is added, according to clinic made from common process by the described in any item pharmaceutical compositions of claim 1-4 The two-component external medicine preparation of upper acceptable treatment bedsore.
7. the two-component external medicine preparation for the treatment of bedsore according to claim 6, which is characterized in that including previous tretament The second pharmaceutical preparation that the first pharmaceutical preparation and ulcer of ulcer use more afterwards；
First pharmaceutical preparation, second pharmaceutical preparation include spray, drops, liniment, paste and/or paint.
8. a kind of method for the two-component external medicine preparation for preparing treatment bedsore described in claim 6 or 7, including preparation institute The step of stating the first pharmaceutical preparation and the step of preparing the second pharmaceutical preparation；It is characterized by:
The preparation method of first pharmaceutical preparation, includes the following steps:
(1) it takes a selected amount of root of fangji, dragon's blood, rhizoma dioscoreae nipponicae, monkshood, radix cyathulae, corydalis tuber, Paris polyphylla, safflower, lopseed, stretch muscle Grass, pericarpium zanthoxyli, Hedyotidis Diffusae, Radix Angelicae Pubescentis, caulis trachelospermi, caulis piperis futokadsurae, radix saposhnikoviae, Radix Salviae Miltiorrhizae, bush, olibanum, myrrh, and add water to be soaked respectively It steeps and boils, collect filtrate and be concentrated, obtain Chinese medical extract, it is spare；
(2) taking a selected amount of dried venom of toads, scorpio and centipede is raw material, and water is added to extract, and collection filtrate is chilled and freezes After drying, freeze-dried powder is made, it is spare；
(3) gained Chinese medical extract and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, according to routine Clinically acceptable external preparation is made in technique；
The preparation method of the second pharmaceutical preparation, includes the following steps:
(1 ') takes a selected amount of folium isatidis, Radix Isatidis, Radix Paeoniae Alba, setose thistle, the larva of a silkworm with batrytis, the root of Dahurain angelica, rhizoma ligustici, the coptis, frutus cnidii, ice Piece, Radix Notoginseng, folium artemisiae argyi, peppermint, honeysuckle, Radix Angelicae Sinensis, wrinkled giant hyssop, chrysanthemum, lotus, Sculellaria barbata, and add water to be impregnated and boiled respectively, After collecting filtrate and being concentrated, Chinese medical extract is obtained, it is spare；
It is raw material that (2 '), which take a selected amount of dried venom of toads, scorpio and gecko, and water is added to extract, and collection filtrate is chilled and freezes After drying, freeze-dried powder is made, it is spare；
(3 ') mix gained Chinese medical extract and a selected amount of insect protein freeze-dried powder, customary adjuvant are added, according to normal Clinically acceptable external preparation is made in rule technique.
9. the method for the two-component external medicine preparation according to claim 8 for preparing the treatment bedsore, feature exist In:
In the step (1), the dragon's blood, monkshood, radix cyathulae, pericarpium zanthoxyli, Radix Angelicae Pubescentis, radix saposhnikoviae, Radix Salviae Miltiorrhizae, olibanum, myrrh tanning when Between be 45min；The root of fangji, rhizoma dioscoreae nipponicae, Paris polyphylla, lycopodium calvatum, Hedyotidis Diffusae, caulis piperis futokadsurae, bush the tanning time be 40min； The corydalis tuber, safflower, lopseed, caulis trachelospermi the tanning time be 20min；
In the step (1 '), the Radix Paeoniae Alba, setose thistle, rhizoma ligustici, frutus cnidii, borneol, Radix Angelicae Sinensis the tanning time be 45min；It is described Folium isatidis, Radix Isatidis, the larva of a silkworm with batrytis, the coptis, Radix Notoginseng, folium artemisiae argyi, peppermint the tanning time be 40min；The root of Dahurain angelica, honeysuckle, the leaves of pulse plants Perfume, chrysanthemum, lotus, Sculellaria barbata the tanning time be 20min.
10. the method for the two-component external medicine preparation for preparing the treatment bedsore according to claim 8 or claim 9, special Sign is, further includes that white wine and/or mountain are added in the Chinese medical extract in the step (1) and/or the step (1 ') The step of potassium sorbate.
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Application publication date: 20190322