CN109498657A - A kind of paracetamol caffein atificial cow-bezoar of antipyretic effect and preparation method thereof - Google Patents
A kind of paracetamol caffein atificial cow-bezoar of antipyretic effect and preparation method thereof Download PDFInfo
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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Abstract
The invention discloses a kind of paracetamol caffein atificial cow-bezoar of antipyretic effect, the weight percent of each raw material are as follows: Paracetamol 60-65%, caffeine 3-4%; chlorphenamine maleate 0.2-0.3%; calculus bovis factitius 2-3%, dextrin 1-1.5%, cornstarch 28-33%；The present invention is by pouring into storage box for Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius; vibrator vibration is controlled by control panel; then raw material is out of filter opening decline slot-in type mixing machine main body; impurity is eliminated as far as possible to be mixed into wherein; the mounting base of filter mechanism is installed between the two clamping plates of mounting groove simultaneously; it avoids vibration from passing to the trough type mixing machine main body of lower section by the snubber of two lateral springs when vibrator shakes, is convenient for real protection trough type mixing machine main body；Simultaneously after softwood manufactures successfully, trough type mixing machine main body is put into the transport case that softwood is fallen into transport establishment by stirring bucket reversion, by pulling handle that idler wheel rotation is driven to improve the producing efficiency of paracetamol caffein atificial cow-bezoar convenient for materials and transport of materials.
Description
Technical field
The present invention relates to paracetamol caffein atificial cow-bezoar production field, the paracetamol caffein atificial cow-bezoar of specially a kind of antipyretic effect and
Preparation method.
Background technique
Paracetamol caffein atificial cow-bezoar, commonly uses cold drug, and ammonia adds the analgesic activity of paracetamol in yellow quick capsule to may be logical
It crosses and inhibits the synthesis of prostaglandin in central nervous system and block the impulsion of pain nerve tip and generate analgesia, Hou Zheke
Can with inhibit prostaglandin or other the synthesis of substance of pain receptor sensitivity can be made related；Refrigeration function then may be by down
Thalamus heat-regulating centers generates peripheral vasodilation, perspires with radiating and works, and may be with the prostaglandin of hypothalamus
Synthesis is suppressed related；The maincenter that caffeine low dose acts on a cerebral cortex high position makes mental excitation, relieving fatigue, and can
Make cerebral vasoconstriction, alleviates headache caused by cerebral vasodilators, mitigate allergic symptom；Anti- m choline receptor effect, keeps schneiderian membrance dry
It is dry；Calculus bovis factitius has antipyretic and anti-inflammatory effect.
Existing paracetamol caffein atificial cow-bezoar needs to carry out raw material mixing and softwood preparation in preparation process, needs using slot
Type mixing machine, and trough type mixing machine directly pours into raw material in stirring bucket in use process, impurity when raw material being be easy to cause to mix
It is mixed into wherein, drug is caused to go wrong；Simultaneously after softwood manufactures successfully, the materials and transport of materials of trough type mixing machine compare
It is more complex.
Summary of the invention
The purpose of the present invention is to provide paracetamol caffein atificial cow-bezoar of a kind of antipyretic effect and preparation method thereof, in order to gram
Above-mentioned technical problem is taken, the trough type mixing machine in preparation method can pour into stirring bucket in raw material and filter mechanism is added to original
Material is filtered processing, and elimination impurity as far as possible is mixed into wherein, influences drug effect；Simultaneously after softwood manufactures successfully, pass through transporter
Structure improves the producing efficiency of paracetamol caffein atificial cow-bezoar convenient for materials and transport of materials.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of paracetamol caffein atificial cow-bezoar of antipyretic effect, the weight percent of each raw material are as follows: Paracetamol 60-
65%, caffeine 3-4%, chlorphenamine maleate 0.2-0.3%, calculus bovis factitius 2-3%, dextrin 1-1.5%, cornstarch
28-33%；
The paracetamol caffein atificial cow-bezoar is prepared by following step:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, maleic acid chlorine respectively by weight percentage
Cornstarch is put into clean container, cornstarch is rushed with cold water by benzene that quick, calculus bovis factitius, dextrin and cornstarch
It dissipates, adds boiling water, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius softwood preparation: are passed through into slot respectively
Stirring 20 ± 5 minutes is covered in type mixing machine, adds 10% starch slurry to stir evenly in right amount and softwood is made；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into particle
Complete gradation in machine, particle be then put into ebullated dryer and is dried, when dry pressure control in 0.2Mpa-0.4Mpa,
± 5 minutes 35 minutes drying time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture takes in < 3.0%
Rewinding after sample hole takes dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, dried particle is put into quickly whole
Grain machine completes whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, are driven
Test-run a machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
A kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect, the preparation method of the paracetamol caffein atificial cow-bezoar are specific
Steps are as follows:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, maleic acid chlorine respectively by weight percentage
Cornstarch is put into clean container, cornstarch is rushed with cold water by benzene that quick, calculus bovis factitius, dextrin and cornstarch
It dissipates, adds boiling water, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius softwood preparation: are passed through into slot respectively
Stirring 20 ± 5 minutes is covered in type mixing machine, the mounting base of transport establishment is sticked between two pieces of fixture blocks of mounting groove and is completed
Then Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius are successively poured into storage box, pass through control by installation
Panel controls vibrator vibration, and then raw material removes the impurity in raw material, raw material out of filter opening decline slot-in type mixing machine main body
Capping stirring 10% starch slurry of addition stirs evenly in right amount in trough type mixing machine main body is made softwood, then inverts stirring bucket,
Softwood falls into the transport case of transport establishment, extracts transport case out out of T-type sliding slot, by pulling handle, passes through idler wheel transport
Softwood in case is easy to use；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into particle
Complete gradation in machine, particle be then put into ebullated dryer and is dried, when dry pressure control in 0.2Mpa-0.4Mpa,
± 5 minutes 35 minutes drying time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture takes in < 3.0%
Rewinding after sample hole takes dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, dried particle is put into quickly whole
Grain machine completes whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, are driven
Test-run a machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
As a further solution of the present invention: trough type mixing machine described in step 2 includes trough type mixing machine main body, filtering
Mechanism, transport establishment, mounting groove, T-type sliding slot, spring and fixture block, the trough type mixing machine body top are equipped with filter mechanism,
The trough type mixing machine bottom part body is equipped with transport establishment；
Trough type mixing machine body top two sides are provided with mounting groove, the trough type mixing machine main body inside symmetrical two
Wall offers T-type sliding slot, and both ends are symmetrically installed with several springs, the spring one end installation on the inside of the mounting groove
There is fixture block；
The filter mechanism includes storage box, feeding inlet, cover board, mounting base, control panel, vibrator and filter opening, described
Storage box top side offers feeding inlet, the storage box and is located at feeding inlet side hinge and is connected with cover board, the storage
Case two sides are symmetrically installed with mounting base, and the other side is equipped with control panel, the storage box top center at the top of the storage box
Place is equipped with vibrator, and the storage box bottom offers several filter openings；
The transport establishment includes transport case, swivel base, handle, T-type fixture block and idler wheel, and the transport case two sides are symmetrically installed
There is T-type fixture block, the transport case other side is equipped with swivel base, is connected with handle, the transport case bottom on the inside of the swivel base
Portion is equipped with idler wheel.
As a further solution of the present invention: the control panel is electrically connected vibrator, and the vibrator passes through bolt
It is mounted at the top of storage box.
As a further solution of the present invention: the T-type sliding slot and T-type fixture block are used cooperatively.
Beneficial effects of the present invention:
1, Paracetamol of the invention can inhibit prostaglandin to synthesize, and have antipyretic effect；Coffee is because maincenter is emerging
It puts forth energy medicine, the antipyretic-antalgic effect of paracetamol can be enhanced, and mitigate the CNS inhibitions such as drowsiness, dizzy caused by other drugs
Effect；Chlorphenamine maleate is antihistamine, can mitigate runny nose, nasal obstruction, sneezing symptom；Calculus bovis factitius has antipyretic, town
Frightened effect；
2, the trough type mixing machine in the preparation method of paracetamol caffein atificial cow-bezoar can pour into raw material and filtering is added in stirring bucket
Mechanism is filtered processing to raw material, is deposited by pouring into Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius
Case is put, vibrator vibration is controlled by control panel, then raw material is eliminated as far as possible out of filter opening decline slot-in type mixing machine main body
Impurity is mixed into wherein, influences drug effect, while the mounting base of filter mechanism is installed between the two clamping plates of mounting groove, vibrator shake
It avoids vibration from passing to the trough type mixing machine main body of lower section by the snubber of two lateral springs when dynamic, is convenient for real protection groove profile
Mixing machine main body；Simultaneously after softwood manufactures successfully, trough type mixing machine main body is put into stirring bucket reversion and softwood is fallen into transporter
The transport case of structure, by pulling handle that idler wheel rotation is driven to improve the production of paracetamol caffein atificial cow-bezoar convenient for materials and transport of materials
Efficiency.
Detailed description of the invention
In order to facilitate the understanding of those skilled in the art, the present invention will be further described below with reference to the drawings.
Fig. 1 is trough type mixing machine overall structure diagram of the present invention.
Fig. 2 is present invention installation slot structure schematic diagram.
Fig. 3 is filter mechanism structural schematic diagram of the present invention.
Fig. 4 is filter mechanism bottom view of the present invention.
Fig. 5 is transport establishment's structural schematic diagram of the present invention.
Fig. 6 is transport establishment's side view of the present invention.
In figure: 1, trough type mixing machine main body；2, filter mechanism；3, transport establishment；101, mounting groove；102, T-type sliding slot；
103, spring；104, fixture block；201, storage box；202, feeding inlet；203, cover board；204, mounting base；205, control panel；206,
Vibrator；207, filter opening；301, transport case；302, swivel base；303, handle；304, T-type fixture block；305, idler wheel；
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff all other embodiment obtained without creative efforts belongs to what the present invention protected
Range.
It please refers to shown in Fig. 1-6, a kind of paracetamol caffein atificial cow-bezoar of antipyretic effect, the weight percent of each raw material are as follows:
Paracetamol 60-65%, caffeine 3-4%, chlorphenamine maleate 0.2-0.3%, calculus bovis factitius 2-3%, dextrin 1-
1.5%, cornstarch 28-33%；
The paracetamol caffein atificial cow-bezoar is prepared by following step:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, maleic acid chlorine respectively by weight percentage
Cornstarch is put into clean container, cornstarch is rushed with cold water by benzene that quick, calculus bovis factitius, dextrin and cornstarch
It dissipates, adds boiling water, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius softwood preparation: are passed through into slot respectively
Stirring 20 ± 5 minutes is covered in type mixing machine, adds 10% starch slurry to stir evenly in right amount and softwood is made；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into particle
Complete gradation in machine, particle be then put into ebullated dryer and is dried, when dry pressure control in 0.2Mpa-0.4Mpa,
± 5 minutes 35 minutes drying time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture takes in < 3.0%
Rewinding after sample hole takes dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, dried particle is put into quickly whole
Grain machine completes whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, are driven
Test-run a machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
A kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect, the preparation method of the paracetamol caffein atificial cow-bezoar are specific
Steps are as follows:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, maleic acid chlorine respectively by weight percentage
Cornstarch is put into clean container, cornstarch is rushed with cold water by benzene that quick, calculus bovis factitius, dextrin and cornstarch
It dissipates, adds boiling water, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius softwood preparation: are passed through into slot respectively
Stirring 20 ± 5 minutes is covered in type mixing machine, and the mounting base 204 of transport establishment 3 is sticked into two pieces of fixture blocks 104 of mounting groove 101
Between complete installation, Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius then successively poured into storage box 201,
It controls vibrator 206 by control panel 205 to vibrate, then raw material is gone out of filter opening 207 decline slot-in type mixing machine main body 1
Except the impurity in raw material, raw material, which covers stirring in trough type mixing machine main body 1 10% starch slurry is added, to stir evenly be made in right amount
Then softwood inverts stirring bucket, softwood falls into the transport case 301 of transport establishment 3, extracts transport case 301 out out of T-type sliding slot 102,
By pulling handle 303, by the softwood in 305 transport case 301 of idler wheel, it is easy to use；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into particle
Complete gradation in machine, particle be then put into ebullated dryer and is dried, when dry pressure control in 0.2Mpa-0.4Mpa,
± 5 minutes 35 minutes drying time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture takes in < 3.0%
Rewinding after sample hole takes dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, dried particle is put into quickly whole
Grain machine completes whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, are driven
Test-run a machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
Trough type mixing machine includes trough type mixing machine main body 1, filter mechanism 2, transport establishment 3, mounting groove 101, T in step 2
Type sliding slot 102, spring 103 and fixture block 104 are equipped with filter mechanism 2, trough type mixing machine main body 1 at the top of trough type mixing machine main body 1
Bottom is equipped with transport establishment 3；
1 top two sides of trough type mixing machine main body are provided with mounting groove 101,1 symmetrical two wall in inside of trough type mixing machine main body
T-type sliding slot 102 is offered, 101 inside both ends of mounting groove are symmetrically installed with several springs 103, and 103 one end of spring is equipped with
Fixture block 104；
Filter mechanism 2 includes storage box 201, feeding inlet 202, cover board 203, mounting base 204, control panel 205, vibrator
206 and filter opening 207,201 top side of storage box offers feeding inlet 202, storage box 201 and is located at 202 side of feeding inlet and cuts with scissors
Chain link has cover board 203, and 201 two sides of storage box are symmetrically installed with mounting base 204, and the 201 top other side of storage box is equipped with control
Panel 205 processed is equipped with vibrator 206 at 201 top center of storage box, and 201 bottom of storage box offers several filter openings
207；
Transport establishment 3 includes transport case 301, swivel base 302, handle 303, T-type fixture block 304 and idler wheel 305, transport case 301
Two sides are symmetrically installed with T-type fixture block 304, and 301 other side of transport case is equipped with swivel base 302, are connected with and turn on the inside of swivel base 302
303,301 bottom of transport case is equipped with idler wheel 305.
Control panel 205 is electrically connected vibrator 206, convenient for controlling the work vibration of vibrator 206 by control panel 205
Dynamic, vibrator 206 is mounted on 201 top of storage box by bolt, convenient for the installation and removal of vibrator 206.
T-type sliding slot 102 and T-type fixture block 304 are used cooperatively, be readily transported case 301 be mounted on trough type mixing machine main body 1 it
Between, while also transport easy to disassemble.
Beneficial effects of the present invention:
1, Paracetamol of the invention can inhibit prostaglandin to synthesize, and have antipyretic effect；Coffee is because maincenter is emerging
It puts forth energy medicine, the antipyretic-antalgic effect of paracetamol can be enhanced, and mitigate the CNS inhibitions such as drowsiness, dizzy caused by other drugs
Effect；Chlorphenamine maleate is antihistamine, can mitigate runny nose, nasal obstruction, sneezing symptom；Calculus bovis factitius has antipyretic, town
Frightened effect；
2, the trough type mixing machine in the preparation method of paracetamol caffein atificial cow-bezoar can pour into raw material and filtering is added in stirring bucket
Mechanism 2 is filtered processing to raw material, by pouring into Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius
Storage box 201 controls vibrator 206 by control panel 205 and vibrates, and then raw material is from 207 decline slot-in type mixing machine of filter opening
In main body 1, elimination impurity as far as possible is mixed into wherein, influences drug effect, while the mounting base 204 of filter mechanism 2 is installed on mounting groove 101
Two clamping plates between, vibrator 206 shake when by the snubber of two lateral springs 103 avoid vibration pass to lower section slot
Type mixing machine main body 1 is convenient for real protection trough type mixing machine main body 1；Simultaneously after softwood manufactures successfully, trough type mixing machine main body
1 is put into the transport case 301 that softwood is fallen into transport establishment 3 by stirring bucket reversion, by pulling handle 303 that idler wheel 305 is driven to rotate,
Convenient for materials and transport of materials, the producing efficiency of paracetamol caffein atificial cow-bezoar is improved.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, also do not limit the specific embodiment that the invention is only.Obviously, according to the content of this specification, can make
Many modifications and variations.These embodiments are chosen and specifically described to this specification, is original in order to better explain the present invention
Reason and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only authorized
The limitation of sharp claim and its full scope and equivalent.
Claims (5)
1. a kind of paracetamol caffein atificial cow-bezoar of antipyretic effect, which is characterized in that the weight percent of each raw material are as follows: acetylamino
Phenol 60-65%, caffeine 3-4%, chlorphenamine maleate 0.2-0.3%, calculus bovis factitius 2-3%, dextrin 1-1.5%, corn
Starch 28-33%；
The paracetamol caffein atificial cow-bezoar is prepared by following step:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, chlorphenamine maleate respectively by weight percentage
Cornstarch is put into clean container, cornstarch is broken up with cold water by quick, calculus bovis factitius, dextrin and cornstarch, then
Boiling water is added, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: softwood preparation: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius are mixed by groove profile respectively
Stirring 20 ± 5 minutes is covered in conjunction machine, adds 10% starch slurry to stir evenly in right amount and softwood is made；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into granulator
Gradation is completed, particle is then put into ebullated dryer and is dried, pressure control is in 0.2Mpa-0.4Mpa, drying when dry
± 5 minutes 35 minutes time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture is in < 3.0%, sampling hole
Rewinding after taking dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, and dried particle is put into Fastgranulatemachine
Complete whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, examination of driving
Machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
2. a kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect, which is characterized in that the system of the paracetamol caffein atificial cow-bezoar
Specific step is as follows for Preparation Method:
Step 1: it weighs and prepares: weighing suitable Paracetamol, caffeine, chlorphenamine maleate respectively by weight percentage
Cornstarch is put into clean container, cornstarch is broken up with cold water by quick, calculus bovis factitius, dextrin and cornstarch, then
Boiling water is added, stirring while adding, wherein the ratio of cornstarch and water is 1:9；
Step 2: softwood preparation: Paracetamol, chlorphenamine maleate, caffeine, calculus bovis factitius are mixed by groove profile respectively
Stirring 20 ± 5 minutes is covered in conjunction machine, and the mounting base (204) of transport establishment (3) is sticked into two pieces of folders of mounting groove (101)
Installation is completed between block (104), and successively then Paracetamol, chlorphenamine maleate, caffeine and calculus bovis factitius are poured into and deposited
Case (201) are put, by control panel (205) control vibrator (206) vibration, then raw material is from filter opening (207) decline slot-in type
In mixing machine main body (1), the impurity in raw material is removed, raw material capping stirring in trough type mixing machine main body (1) is added 10% and forms sediment
Slurry stirs evenly in right amount is made softwood, then inverts stirring bucket, softwood falls into the transport case (301) of transport establishment (3), from T
Transport case (301) are extracted out in type sliding slot (102), by pulling handle (303), by idler wheel (305) transport case (301)
Softwood, be easy to use；
Step 3: granulation and drying: installing 20 mesh nylon screens on oscillating granulator, and the softwood made is moved into granulator
Gradation is completed, particle is then put into ebullated dryer and is dried, pressure control is in 0.2Mpa-0.4Mpa, drying when dry
± 5 minutes 35 minutes time/material, 70 DEG C ± 5 DEG C of inlet air temperature, 35 DEG C ± 5 DEG C of leaving air temp, moisture is in < 3.0%, sampling hole
Rewinding after taking dry particle range estimation qualified；
Step 4: whole grain: installing 16 mesh stainless steel mesh in Fastgranulatemachine, and dried particle is put into Fastgranulatemachine
Complete whole grain；
Step 5: total mix: the good particle of whole grain and dextrin investment two-dimensional motion mixer are mixed 25 ± 5 minutes；
Step 6: capsule filling: particle and Capsules are respectively placed in automatic hard capsule filler hopper, examination of driving
Machine, vacuum degree are -0.010~-0.080Mpa, and fill rate is 1100-1200/minute, production run after adjusting in capsule；
Step 7: polishing: filled capsule is put into polishing treatment in polishing machine.
3. a kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect according to claim 2, which is characterized in that
Trough type mixing machine described in step 2 includes trough type mixing machine main body (1), filter mechanism (2), transport establishment (3), mounting groove
(101), T-type sliding slot (102), spring (103) and fixture block (104), trough type mixing machine main body (1) top are equipped with filter
Structure (2), trough type mixing machine main body (1) bottom are equipped with transport establishment (3)；
Two sides are provided with mounting groove (101) at the top of the trough type mixing machine main body (1), in the trough type mixing machine main body (1)
Symmetrical two wall in side offers T-type sliding slot (102), and both ends are symmetrically installed with several bullets on the inside of the mounting groove (101)
Spring (103), described spring (103) one end are equipped with fixture block (104)；
The filter mechanism (2) includes storage box (201), feeding inlet (202), cover board (203), mounting base (204), control panel
(205), vibrator (206) and filter opening (207), storage box (201) top side offers feeding inlet (202), described to deposit
It puts case (201) and is located at feeding inlet (202) side hinge and be connected with cover board (203), storage box (201) two sides are symmetrically installed
Have mounting base (204), the other side is equipped with control panel (205) at the top of the storage box (201), storage box (201) top
It is equipped at portion center vibrator (206), storage box (201) bottom offers several filter openings (207)；
The transport establishment (3) includes transport case (301), swivel base (302), handle (303), T-type fixture block (304) and idler wheel
(305), transport case (301) two sides are symmetrically installed with T-type fixture block (304), and transport case (301) other side, which is equipped with, to be turned
Seat (302), swivel base (302) inside are connected with handle (303), and transport case (301) bottom is equipped with idler wheel
(305)。
4. a kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect according to claim 3, which is characterized in that
The control panel (205) is electrically connected vibrator (206), and the vibrator (206) is mounted on storage box (201) by bolt
Top.
5. a kind of preparation method of the paracetamol caffein atificial cow-bezoar of antipyretic effect according to claim 3, which is characterized in that
The T-type sliding slot (102) and T-type fixture block (304) are used cooperatively.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114191395A (en) * | 2021-12-07 | 2022-03-18 | 葵花药业集团(唐山)生物制药有限公司 | Granulating method with uniform granules |
| CN115227722A (en) * | 2022-08-25 | 2022-10-25 | 陕西颐生堂药业有限公司 | Preparation method of Paracetamol, caffein and chlorphenamine maleate capsules |
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| CN109498657B (en) | 2022-03-22 |
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Denomination of invention: An ampaca yellow min capsule with antipyretic and analgesic effect and its preparation method Effective date of registration: 20230228 Granted publication date: 20220322 Pledgee: Huainan Branch of Postal Savings Bank of China Pledgor: ANHUI DONGSHENG YOUBANG PHARMACEUTICAL CO.,LTD. Registration number: Y2023980033712 |