CN109487439A - A kind of preparation method of xanthan gum/chitosan nano fiber membrane - Google Patents
A kind of preparation method of xanthan gum/chitosan nano fiber membrane Download PDFInfo
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- CN109487439A CN109487439A CN201811360241.1A CN201811360241A CN109487439A CN 109487439 A CN109487439 A CN 109487439A CN 201811360241 A CN201811360241 A CN 201811360241A CN 109487439 A CN109487439 A CN 109487439A
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- xanthan gum
- chitosan
- fiber membrane
- nano fiber
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Artificial Filaments (AREA)
Abstract
The invention discloses a kind of preparation methods of xanthan gum/chitosan nano fiber membrane, include the following steps: step 1, and xanthan gum and chitosan are dissolved in an acidic solution, 20-40h is vigorously mixed at room temperature for, obtains viscoelastic gel solution；Step 2, curcumin is added into viscoelastic gel solution, is mixed and stirred for dissolution 10-60min, obtains uniform mixed solution；Step 3, mixed solution is put into Ultrasound Instrument and is ultrasonically treated 5-30min, obtain xanthan gum-chitosan-curcumin nano composite solution；Step 4, xanthan gum-chitosan-curcumin nano composite solution is injected into the plastic injector of 10mL by 21-G stainless pin, and is connected to progress electrostatic spinning reaction on syringe pump, obtain nano fibrous membrane；Step 5, nano fibrous membrane is isolated, and dries 10-30h at room temperature, obtain xanthan gum/chitosan nano fiber membrane.The present invention encapsulates the structure of curcumin by xanthan gum/chitosan nano fiber membrane to promote release duration.
Description
Technical field
The invention belongs to pharmaceutical carrier technical field of biological materials more particularly to a kind of xanthan gum/chitosan nano fibers
The preparation method of film.
Background technique
Curcumin is a kind of phenolic compound, and medicinal property is considered as antioxidant, antibacterial agent, anti-inflammatory agent, tumour
Generation and transfer inhibitor.But due to its hydrophobicity and subsequent poor bioavailability, new technology need to be studied and carried as delivering
Body.
Effective delivering of hydrophobic bioactive substance needs encapsulating appropriate to overcome it low molten in aqueous body fluid
Problem Xie Du related to unstability and limited bioavilability etc..Electrohydrodynamics (electrostatic spinning and electron spray)
Method is ground extensively due to its high packaging efficiency, low technological temperature and using extensive biological food activity and shell component
Study carefully.In addition, electrospinning fibre has high surface area, the surface of adjustable diameter and functionalization, this makes it be used to encapsulate and control biology
Activity release aspect is very noticeable.
The cationic polysaccharide that chitosan (Ch) is made of N- acetyl glucosamine and aminoglucose, with good biofacies
Capacitive, biological degradability and mucosa-adherent and enhancing gastrointestinal drug absorb ability and it is famous.Xanthan gum is a kind of yin
Nonionic polysaccharide, it is famous with its unique physicochemical properties, and have been used as encapsulation matrix.
Therefore, this field needs to develop a kind of carrier that can be used as encapsulating hydrophobic bioactive compound, need to have
High encapsulation efficiencies, good physical stability in an aqueous medium, and there is long-term pH to stimulate releasing properties, avoid drug special
The some limitations of the excellent bioactive compound of property in use.
Summary of the invention
For the problems of the prior art, the present invention provides a kind of preparation method of xanthan gum/chitosan nano fiber membrane,
The limitation of existing bioactive compound in use is solved, ginger is encapsulated by xanthan gum/chitosan nano fiber membrane
The structure of flavine promotes release duration.
To realize the above technical purpose, the technical scheme is that
A kind of preparation method of xanthan gum/chitosan nano fiber membrane, includes the following steps:
Step 1, in an acidic solution by xanthan gum and chitosan dissolution, it is vigorously mixed at room temperature for 20-40h, is glued
Elastic gel solution；
Step 2, curcumin is added into viscoelastic gel solution, is mixed and stirred for dissolution 10-60min, obtains uniform
Mixed solution；
Step 3, mixed solution is put into Ultrasound Instrument and is ultrasonically treated 5-30min, obtain xanthan gum-chitosan-curcumin
Nanocomposite solution；
Step 4, xanthan gum-chitosan-curcumin nano composite solution is injected into 10mL's by 21-G stainless pin
In plastic injector, and it is connected to progress electrostatic spinning reaction on syringe pump, obtains nano fibrous membrane；
Step 5, nano fibrous membrane is isolated, and dries 10-30h at room temperature, obtain xanthan gum/chitosan nano fiber
Film.
Xanthan gum in the step 1 uses medical grade xanthan gum, and weight average molecular weight is 500-3000 ten thousand.
The concentration of xanthan gum in the step 1 is 0.5-1.0% (g/mL).
Chitosan in the step 1 uses pharmaceutical grade chitosan, and weight average molecular weight is 20-50 ten thousand.
The concentration of chitosan in the step 1 is 1-10% (g/mL).
The deacetylation of chitosan in the step 1 is 85-95%.
Acid solution in the step 1 uses one of formic acid, acetic acid or phosphoric acid solution or several.
The concentration of curcumin in the step 2 is 1-5% (g/mL).
The power of Ultrasound Instrument in the step 3 is 1000W, intensity of sonification 40%.
The parameter of electrostatic spinning in the step 4 is as follows: spinning voltage 20-40KV, fltting speed 2-10mL/h,
Receiving distance is 10-30cm.
From the above, it can be seen that the present invention has following advantages:
1. the present invention solves the limitation of existing bioactive compound in use, pass through xanthan gum/chitosan
Nano fibrous membrane encapsulates the structure of curcumin to promote release duration.
2. the present invention has high encapsulation efficiencies using xanthan gum/chitosan nano fiber as the carrier of encapsulating curcumin,
Physical stability in an aqueous medium, and there is long-term pH to stimulate releasing properties.
3. nanofiber membrane structure provided by the invention can effectively promote the permeability of curcumin, while reduce fibre
The adhesion property of dimension.
4. preparation method provided by the invention is easily understood, facilitate operation, exploitativeness is strong.
Detailed description of the invention
Fig. 1 is the fiber SEM figure of the embodiment of the present invention 1.
Specific embodiment
In conjunction with Fig. 1, the specific embodiment that the present invention will be described in detail, but any limit is not done to claim of the invention
It is fixed.
Embodiment 1
A kind of preparation method of xanthan gum/chitosan nano fiber membrane, includes the following steps:
(1) preparation of electrospinning liquid:
1g xanthan gum (Mw=2000 ten thousand) and 2g (Mw=20 ten thousand) chitosan are dissolved in 100mL formic acid solution first,
Then magnetic force is vigorously stirred 20 hours at room temperature, obtains viscoelastic gel solution.Then 1g curcumin is added to above-mentioned solidifying
In sol solution, it is mixed and stirred for dissolution 20 minutes, obtains uniform solution.Mixed liquor is ultrasonic under 40% intensity of 1000W Ultrasound Instrument
10min is handled, xanthan gum-chitosan-curcumin nano composite solution is prepared.
(2) xanthan gum/chitosan nano fiber membrane manufacture:
The solution for preparing composite material is injected into the plastic injector of 10mL with 21-G stainless pin, and is connected to note
It penetrates on pump.Spinning voltage 20KV, fltting speed 3mL/h, receiving distance is 15cm, is collected on stainless steel with aluminium foil covering,
Obtain thin nanofiber.The nano fibrous membrane of deposition is carefully isolated from collector and to be dried at room temperature for 15 small
When.
SEM figure after fiber prepared by embodiment 1 is put into 1800 times is as shown in Figure 1.
Embodiment 2
A kind of preparation method of xanthan gum/chitosan nano fiber membrane, includes the following steps:
(1) preparation of electrospinning liquid:
0.5g xanthan gum (Mw=1000 ten thousand) and 4g (Mw=40 ten thousand) chitosan are dissolved in 100mL formic acid and phosphoric acid first
In mixed solution, then magnetic force is vigorously stirred 40 hours at room temperature, obtains viscoelastic gel solution.Then 4g curcumin is added
Enter into above-mentioned gel solution, is mixed and stirred for dissolution 60 minutes, obtains uniform solution.Mixed liquor is in 1000W Ultrasound Instrument 40%
It is ultrasonically treated 30min under intensity, prepares xanthan gum-chitosan-curcumin nano composite solution.
(2) xanthan gum/chitosan nano fiber membrane manufacture:
The solution for preparing composite material is injected into the plastic injector of 10mL with 21-G stainless pin, and is connected to note
It penetrates on pump.Spinning voltage 30KV, fltting speed 6mL/h, receiving distance is 15cm, is collected on stainless steel with aluminium foil covering,
Obtain thin nanofiber.The nano fibrous membrane of deposition is carefully isolated from collector and to be dried at room temperature for 25 small
When.
Embodiment 3
A kind of preparation method of xanthan gum/chitosan nano fiber membrane, includes the following steps:
(1) preparation of electrospinning liquid:
0.8g xanthan gum (Mw=500 ten thousand) and 10g (Mw=50 ten thousand) chitosan are dissolved in 100mL formic acid and phosphoric acid first
In mixed solution, then magnetic force is vigorously stirred 30 hours at room temperature, obtains viscoelastic gel solution.Then 5g curcumin is added
Enter into above-mentioned gel solution, is mixed and stirred for dissolution 10 minutes, obtains uniform solution.Mixed liquor is in 1000W Ultrasound Instrument 40%
It is ultrasonically treated 5min under intensity, prepares xanthan gum-chitosan-curcumin nano composite solution.
(2) xanthan gum/chitosan nano fiber membrane manufacture:
The solution for preparing composite material is injected into the plastic injector of 10mL with 21-G stainless pin, and is connected to note
It penetrates on pump.Spinning voltage 40KV, fltting speed 10mL/h, receiving distance is 30cm, is collected on stainless steel with aluminium foil covering,
Obtain thin nanofiber.The nano fibrous membrane of deposition is carefully isolated from collector and to be dried at room temperature for 10 small
When.
Embodiment 4
A kind of preparation method of xanthan gum/chitosan nano fiber membrane, includes the following steps:
(1) preparation of electrospinning liquid:
1g xanthan gum (Mw=3000 ten thousand) and 10g (Mw=50 ten thousand) chitosan are dissolved in 100mL formic acid and phosphoric acid first
In mixed solution, then magnetic force is vigorously stirred 40 hours at room temperature, obtains viscoelastic gel solution.Then 5g curcumin is added
Enter into above-mentioned gel solution, is mixed and stirred for dissolution 50 minutes, obtains uniform solution.Mixed liquor is in 1000W Ultrasound Instrument 40%
It is ultrasonically treated 30min under intensity, prepares xanthan gum-chitosan-curcumin nano composite solution.
(2) xanthan gum/chitosan nano fiber membrane manufacture:
The solution for preparing composite material is injected into the plastic injector of 10mL with 21-G stainless pin, and is connected to note
It penetrates on pump.Spinning voltage 20KV, fltting speed 1mL/h, receiving distance is 10cm, is collected on stainless steel with aluminium foil covering,
Obtain thin nanofiber.The nano fibrous membrane of deposition is carefully isolated from collector and to be dried at room temperature for 30 small
When.
Performance detection
In conclusion the invention has the following advantages that
1. the present invention solves the limitation of existing bioactive compound in use, pass through xanthan gum/chitosan
Nano fibrous membrane encapsulates the structure of curcumin to promote release duration.
2. the present invention has high encapsulation efficiencies using xanthan gum/chitosan nano fiber as the carrier of encapsulating curcumin,
Physical stability in an aqueous medium, and there is long-term pH to stimulate releasing properties.
3. nanofiber membrane structure provided by the invention can effectively promote the permeability of curcumin, while reduce fibre
The adhesion property of dimension.
4. preparation method provided by the invention is easily understood, facilitate operation, exploitativeness is strong.
It is understood that being merely to illustrate the present invention above with respect to specific descriptions of the invention and being not limited to this
Technical solution described in inventive embodiments.Those skilled in the art should understand that still can be carried out to the present invention
Modification or equivalent replacement, to reach identical technical effect；As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (10)
1. a kind of preparation method of xanthan gum/chitosan nano fiber membrane, characterized by the following steps:
Step 1, in an acidic solution by xanthan gum and chitosan dissolution, it is vigorously mixed at room temperature for 20-40h, obtains viscoplasticity
Gel solution；
Step 2, curcumin is added into viscoelastic gel solution, is mixed and stirred for dissolution 10-60min, obtain uniform mix
Close solution；
Step 3, mixed solution is put into Ultrasound Instrument and is ultrasonically treated 5-30min, obtain xanthan gum-chitosan-curcumin nano
Composite solution；
Step 4, xanthan gum-chitosan-curcumin nano composite solution is injected into the plastics of 10mL by 21-G stainless pin
In syringe, and it is connected to progress electrostatic spinning reaction on syringe pump, obtains nano fibrous membrane；
Step 5, nano fibrous membrane is isolated, and dries 10-30h at room temperature, obtain xanthan gum/chitosan nano fiber membrane.
2. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The xanthan gum in step 1 is stated using medical grade xanthan gum, and weight average molecular weight is 500-3000 ten thousand.
3. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The concentration for stating the xanthan gum in step 1 is 0.5-1.0% (g/mL).
4. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The chitosan in step 1 is stated using pharmaceutical grade chitosan, and weight average molecular weight is 20-50 ten thousand.
5. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The concentration for stating the chitosan in step 1 is 1-10% (g/mL).
6. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The deacetylation for stating the chitosan in step 1 is 85-95%.
7. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The acid solution stated in step 1 uses one of formic acid, acetic acid or phosphoric acid solution or several.
8. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The concentration for stating the curcumin in step 2 is 1-5% (g/mL).
9. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The power for stating the Ultrasound Instrument in step 3 is 1000W, intensity of sonification 40%.
10. a kind of preparation method of xanthan gum/chitosan nano fiber membrane according to claim 1, it is characterised in that: institute
The parameter for stating the electrostatic spinning in step 4 is as follows: spinning voltage 20-40KV, fltting speed 2-10mL/h, receives distance and is
10-30cm。
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| CN201811360241.1A CN109487439B (en) | 2018-11-15 | 2018-11-15 | Preparation method of xanthan gum/chitosan nanofiber membrane |
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| CN201811360241.1A CN109487439B (en) | 2018-11-15 | 2018-11-15 | Preparation method of xanthan gum/chitosan nanofiber membrane |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674742A (en) * | 2019-03-07 | 2019-04-26 | 康赋葆(深圳)生物医药科技有限公司 | A kind of curcumin hydrogel matrix slow releasing composition, preparation method and its application in anti-cancer field |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058476A1 (en) * | 2003-12-18 | 2005-06-30 | Gat Formulation Gmbh | Continuous multi-microencapsulation process for improving the stability and storage life of biologically active ingredients |
| CN101638830A (en) * | 2009-08-25 | 2010-02-03 | 江南大学 | Method for preparing nanofibre membrane |
| CN103992997A (en) * | 2014-05-09 | 2014-08-20 | 陕西科技大学 | Method of preparing bifidobacterium microcapsule by utilization of chitosan/xanthan gum and applications of the microcapsule |
| CN104096262A (en) * | 2013-04-09 | 2014-10-15 | 上海交通大学医学院附属第九人民医院 | Collagen/chitosan/mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof |
| CN106957448A (en) * | 2017-02-24 | 2017-07-18 | 黄秋丽 | A kind of xanthans modifies the preparation method of chitosan microball |
| CN107308137A (en) * | 2017-07-05 | 2017-11-03 | 西南大学 | One kind carries curcumin antibacterial fiber film and preparation method thereof |
| CN107475812A (en) * | 2017-09-11 | 2017-12-15 | 苏州佰锐生物科技有限公司 | A kind of electro-spinning for chitosan/curcumin nano antiseptic dressing method |
-
2018
- 2018-11-15 CN CN201811360241.1A patent/CN109487439B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058476A1 (en) * | 2003-12-18 | 2005-06-30 | Gat Formulation Gmbh | Continuous multi-microencapsulation process for improving the stability and storage life of biologically active ingredients |
| CN101638830A (en) * | 2009-08-25 | 2010-02-03 | 江南大学 | Method for preparing nanofibre membrane |
| CN104096262A (en) * | 2013-04-09 | 2014-10-15 | 上海交通大学医学院附属第九人民医院 | Collagen/chitosan/mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof |
| CN103992997A (en) * | 2014-05-09 | 2014-08-20 | 陕西科技大学 | Method of preparing bifidobacterium microcapsule by utilization of chitosan/xanthan gum and applications of the microcapsule |
| CN106957448A (en) * | 2017-02-24 | 2017-07-18 | 黄秋丽 | A kind of xanthans modifies the preparation method of chitosan microball |
| CN107308137A (en) * | 2017-07-05 | 2017-11-03 | 西南大学 | One kind carries curcumin antibacterial fiber film and preparation method thereof |
| CN107475812A (en) * | 2017-09-11 | 2017-12-15 | 苏州佰锐生物科技有限公司 | A kind of electro-spinning for chitosan/curcumin nano antiseptic dressing method |
Non-Patent Citations (2)
| Title |
|---|
| 何东保等: "壳聚糖／黄原胶凝胶化性能的研究", 《武汉大学学报(理学版)》 * |
| 段久芳: "《天然高分子材料》", 30 September 2016, 华中科技大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674742A (en) * | 2019-03-07 | 2019-04-26 | 康赋葆(深圳)生物医药科技有限公司 | A kind of curcumin hydrogel matrix slow releasing composition, preparation method and its application in anti-cancer field |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
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