CN109481602B - Traditional Chinese medicine composition for effectively treating acne and preparation method thereof - Google Patents
Traditional Chinese medicine composition for effectively treating acne and preparation method thereof Download PDFInfo
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- CN109481602B CN109481602B CN201811567117.2A CN201811567117A CN109481602B CN 109481602 B CN109481602 B CN 109481602B CN 201811567117 A CN201811567117 A CN 201811567117A CN 109481602 B CN109481602 B CN 109481602B
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Abstract
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for effectively treating acne and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: the invention summarizes the viewpoints of damp-heat, phlegm accumulation, kidney deficiency, blood stasis and the like on the basis of the traditional pathogenesis of wind-heat, lung heat and blood heat, treats both symptoms and root causes, and can effectively prevent repeated attacks of diseases. In the traditional Chinese medicine composition, the glabrous greenbrier rhizome, the dandelion and the weeping forsythia can achieve the effects of relieving muscles and skin and clearing sore toxin and guiding the medicine to skin, the loquat leaf, the mulberry leaf and the honeysuckle mainly achieve the effects of dispelling wind, clearing away the lung-heat, clearing away heat and promoting the production of body fluid, the black bean and the prepared rehmannia root mainly achieve the effects of promoting diuresis and removing dampness, and clinical verification shows that the traditional Chinese medicine composition has a treatment effect on acne.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for effectively treating acne and a preparation method thereof.
Background
The acne is mainly caused by the fact that testosterone, an androgen in vivo, is excessively secreted, sebaceous glands are stimulated to excessively secrete sebum, horny cells of orifices of hair follicle sebaceous glands are accumulated, sebum is not smoothly excreted, propionibacterium acnes excessively grow, chemical inflammation is caused by stimulation of sebaceous glands and inner walls of hair follicles, or staphylococcus and other pathogenic bacteria are infected to cause more serious inflammatory reaction, and the clinical manifestations of the acne or the acne are different degrees. Acne is a common clinical disease, is a chronic inflammatory dermatosis of pilosebaceous glands, is good at seborrheic parts such as face, chest and back and the like, is mainly acne, pimple and pustule at the initial stage of rash, is accompanied by nodule, cyst, scar and pigmentation at serious stage, and is easy to attack repeatedly. With the continuous improvement of the living standard of people in China and the unreasonable dietary structure, the incidence of diseases of people increases year by year, and the disease is one of the hot subjects of dermatology research. Acne is not only a skin disease, but also a disease closely related to psychological factors, and has great influence on the psychological health and personality tendency of patients, and the more serious acne is, the higher the influence degree is. Severe acne is prone to scarring. Therefore, after suffering from acne, the appearance of people is seriously affected, and the mood and the behavior of the patients are sometimes affected to a certain degree. A boy with severe acne is more likely to develop psychological abnormalities.
For acne, the existing western medicine treatment lacks effective means, and the total methods are not limited to antiandrogen method, follicular sebaceous gland orifice hyperkeratosis inhibition method, bacterial inhibition method and the like, which are used singly or in combination. The common treatment methods comprise oral drug treatment (antibiotics such as minocycline, doxycycline, roxithromycin and the like, hormones such as estrogen and the like, tretinoin such as tretinoin and the like, other drugs such as metronidazole, cimetidine ambroside, zinc preparation and the like), external drug treatment (tretinoin and the like) and combination treatment of the two, and the disease recurrence rate after treatment is high.
Based on the above prior art, the applicant has made a long-lasting and useful search and trial and error, and has conducted a non-limited number of experiments, and finally found a solution to the above technical problem and formed a solution as will be described below.
Disclosure of Invention
In order to solve the problems of the prior art, the invention provides a traditional Chinese medicine composition for effectively treating acne and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme: a traditional Chinese medicine composition for effectively treating acne comprises the following raw material medicines in parts by weight: 40-50 parts of rhizoma smilacis glabrae, 15-25 parts of dandelion, 15-20 parts of fructus forsythiae, 10-20 parts of folium eriobotryae, 10-20 parts of folium mori, 10-20 parts of honeysuckle, 15-25 parts of black beans and 10-20 parts of prepared rehmannia roots.
The traditional Chinese medicine composition for effectively treating acne comprises the following raw material medicines in parts by weight: 45 parts of glabrous greenbrier rhizome, 20 parts of dandelion, 20 parts of weeping forsythia, 15 parts of loquat leaf, 15 parts of mulberry leaf, 15 parts of honeysuckle, 20 parts of black bean and 15 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition for effectively treating acne comprises the following preparation steps:
1) weighing rhizoma Smilacis Glabrae; 2) proportioning rhizoma smilacis glabrae and water, and soaking to obtain a mixture A; 3) decocting the mixture A in the step 2), and filtering to obtain a first main filtrate B and a first filter residue C; 4) adding water into the first filter residue C obtained in the step 3), decocting and filtering to obtain a first filtrate D; 5) combining the first main filtrate B in the step 3) and the first primary filtrate D in the step 4), and performing rotary concentration to obtain a rhizoma smilacis glabrae concentrated solution E; 6) weighing dandelion, fructus forsythiae, loquat leaves, mulberry leaves, honeysuckle, black beans and prepared rehmannia roots, adding water, and decocting to obtain a second main filtrate F and a second filter residue G; 7) adding water into the second filter residue G obtained in the step 6), decocting and filtering to obtain a second filtrate H; 8) combining the second main filtrate F and the second filtrate H, rotating and concentrating to obtain a concentrated solution I; 9) mixing rhizoma Smilacis Glabrae concentrate E and concentrate I, drying, and pulverizing into fine powder; 10) sieving the fine powder; 11) weighing a certain weight part of starch, and sieving; 12) fully mixing the fine powder in the step 10) with the starch in the step 11), then dripping ethanol and uniformly mixing to prepare a soft material, and then sieving, granulating, drying and finishing.
Weighing 45 parts of rhizoma smilacis glabrae in the step 1); in the step 2), according to rhizoma smilacis glabrae: adding water according to the weight ratio of water =1:8, and soaking for 30 min; decocting the mixture A in the step 3) for 60min, and filtering. Adding water which is 8 times of the weight of the filter residue into the first filter residue C in the step 4) and decocting for 30 min; combining the first main filtrate B and the first primary filtrate D in the step 5), and then using a rotary evaporator at the rotating speed of 100 r.min-1Concentrating at 80 ℃ to the ratio of 1: 1; weighing 20 parts of dandelion, 20 parts of fructus forsythiae, 20 parts of black beans and 15 parts of prepared rehmannia roots in the step 6), adding 960 parts of water for decocting, adding 15 parts of loquat leaves, 15 parts of mulberry leaves and 15 parts of honeysuckle in the decocting process, and decocting for 60 min. In the step 7), adding the second filter residue G into water in an amount which is 8 times of the weight of the second filter residue G, decocting and filtering, decocting for 30min, and filtering; combining the second primary filtrate F and the second secondary filtrate H in the step 8) and then performing rotary evaporationRotating speed of 100 r.min-1Concentrating at 80 ℃ to the ratio of 1: 1; drying by adopting a vacuum box in the step 9); in the step 10), the fine powder is sieved by a 80-mesh sieve. The weight part of the starch in the step 11) is 3-5 times of that of the fine powder in the step 10), and the starch passes through a 80-mesh sieve; and 12) fully mixing the fine powder and the starch according to an isometric incremental proportioning method, dripping 85% ethanol, uniformly mixing to prepare a soft material, and sieving with a 20-mesh nylon sieve to prepare the granules, wherein the aim of holding fingers to form a mass and dispersing by light pressure is achieved.
The fine powder is prepared into granules or capsules or tablets or oral preparations.
The invention summarizes the aspects of damp-heat, phlegm accumulation, kidney deficiency, blood stasis and the like on the basis of the traditional pathogenesis of wind heat, lung heat and blood heat, treats both symptoms and root causes, and can effectively prevent repeated attacks of diseases. The traditional Chinese medicine composition is prepared from glabrous greenbrier rhizome, dandelion, weeping forsythia, loquat leaf, mulberry leaf, honeysuckle flower, black bean and prepared rehmannia root as raw materials, the glabrous greenbrier rhizome and the dandelion as main medicines in the traditional Chinese medicine composition can achieve the effects of relieving the muscles and relieving sore throat and guiding the medicines to the skin, the weeping forsythia, loquat leaf, mulberry leaf and honeysuckle flower as ministerial medicines mainly achieve the effects of dispelling wind, clearing away the lung-heat, clearing away heat and promoting the production of body fluid, and the black bean and the prepared rehmannia root mainly achieve the effects of promoting diuresis and removing dampness, and have a treatment effect on acne through clinical verification. The invention also relates to a preparation method of the traditional Chinese medicine composition for effectively treating acne, the method adopts rhizoma smilacis glabrae to be decocted alone, the decoction liquid is combined with the decoction liquid of other medicinal materials for concentration, the preparation process can extract the astilbin in the rhizoma smilacis glabrae to the maximum extent, the content peaks of chlorogenic acid, forsythiaside A and astilbin are determined by an HPLC method, the result accords with the regulation, and the treatment effect is obvious. The medicinal materials are prepared into various preparations according to the formula, the components are complete, and the curative effect is accurate. On the basis of ensuring all the characteristics of the original traditional Chinese medicine decoction pieces, the traditional Chinese medicine decoction pieces can be directly taken with water, are safe and sanitary, are convenient to carry and store, are easy for enterprises to produce and sell, and are compared with the traditional Chinese medicine taking mode: decocting, boiling and the like, and the granular preparation greatly changes the situation that the taking method of the traditional Chinese medicine preparation is complicated.
Drawings
Figure 1 appearance of anti-acne particles.
FIG. 2 chromatogram of control solution.
FIG. 3 is a chromatogram of a sample solution.
FIG. 4 is a graph showing changes before, during and after two weeks of facial acne test in summer test group.
FIG. 5 is a graph showing the change of the human face before, during and after two weeks of the experiment for acne in the autumn experiment group.
Detailed Description
The present invention will be described in further detail with reference to the following examples, which are provided only for illustrating the present invention and are not intended to limit the scope of the present invention.
Example 1: a traditional Chinese medicine composition for effectively treating acne comprises the following raw material medicines in parts by weight: 40 parts of glabrous greenbrier rhizome, 15 parts of dandelion, 15 parts of weeping forsythia, 10 parts of loquat leaf, 10 parts of mulberry leaf, 10 parts of honeysuckle, 15 parts of black bean and 10 parts of prepared rehmannia root; in the formula, the glabrous greenbrier rhizome, the dandelion and the weeping forsythia have the effects of relieving muscles and eliminating sore toxin and guiding the medicine to skin, the loquat leaf, the mulberry leaf and the honeysuckle mainly have the effects of dispelling wind, clearing away the lung-heat, clearing away heat and promoting the production of body fluid, the black bean and the prepared rehmannia root mainly have the effects of promoting diuresis and removing dampness, and the preparation method of the effective traditional Chinese medicine composition for treating acne comprises the following preparation steps: 1) Weighing rhizoma Smilacis Glabrae; 2) proportioning rhizoma smilacis glabrae and water, and soaking to obtain a mixture A; 3) decocting the mixture A in the step 2), and filtering to obtain a first main filtrate B and a first filter residue C; 4) adding water into the first filter residue C obtained in the step 3), decocting and filtering to obtain a first filtrate D; 5) combining the first main filtrate B in the step 3) and the first primary filtrate D in the step 4), and performing rotary concentration to obtain a rhizoma smilacis glabrae concentrated solution E; 6) weighing dandelion, fructus forsythiae, loquat leaves, mulberry leaves, honeysuckle, black beans and prepared rehmannia roots, adding water, and decocting to obtain a second main filtrate F and a second filter residue G; 7) adding water into the second filter residue G obtained in the step 6), decocting and filtering to obtain a second filtrate H; 8) combining the second main filtrate F and the second filtrate H, rotating and concentrating to obtain a concentrated solution I; 9) mixing rhizoma Smilacis Glabrae concentrate E and concentrate I, drying, and pulverizing into fine powder; making into granule, capsule, tablet or oral preparation. 10) Sieving the fine powder; 11) weighing a certain weight part of starch, and sieving; 12) fully mixing the fine powder in the step 10) with the starch in the step 11), then adding ethanol dropwise, uniformly mixing to prepare a soft material, then sieving, granulating, drying and grading to obtain a granular preparation, wherein the traditional Chinese medicinal materials are prepared into granules according to a formula, so that the traditional Chinese medicinal decoction pieces are ensured to have accurate curative effect and complete components, and compared with the traditional Chinese medicine, the traditional Chinese medicine has the following administration mode: decocting, boiling and the like, the granular preparation greatly changes the situation of fussy traditional Chinese medicine taking method, 40 parts of glabrous greenbrier rhizome are weighed in the step 1), and the weight of the glabrous greenbrier rhizome is calculated according to the weight of the glabrous greenbrier rhizome in the step 2): adding water according to the weight ratio of water =1:8, and soaking for 30 min; decocting the mixture A in the step 3) for 60min and filtering; adding water which is 8 times of the weight of the filter residue into the first filter residue C in the step 4) and decocting for 30 min; rotationally concentrating to the ratio of 1:1 in the step 5), wherein the first main filtrate B and the first primary filtrate D are combined and then concentrated to the ratio of 1:1 by using a rotary evaporator at the rotating speed of 100 r.min-1 and the temperature of 80 ℃; weighing 15 parts of dandelion, 15 parts of fructus forsythiae, 15 parts of black beans and 10 parts of prepared rehmannia roots in step 6), adding 680 parts of water for decoction, and adding 10 parts of loquat leaves, 10 parts of mulberry leaves and 10 parts of honeysuckle into the mixture during decoction for 10-20min for decoction for 60 min; in the step 7), adding the second filter residue G into water in an amount which is 8 times of the weight of the second filter residue G, decocting and filtering for 30min, and filtering; rotating and concentrating to the ratio of 1:1 in the step 8); drying by adopting a vacuum box in the step 9); sieving the fine powder with a 80-mesh sieve in the step 10); in the step 11), the weight part of the starch is 3-5 times of that of the fine powder in the step 10), and the starch passes through a 80-mesh sieve; and step 12) fully mixing the fine powder and starch according to an isometric incremental proportioning method, dripping 85% ethanol, uniformly mixing to prepare a soft material, achieving the purposes of finger holding and conglobation, dispersing by light pressure, and granulating by a 20-mesh nylon sieve. If a traditional water decoction method is adopted, the effective components in various traditional Chinese medicinal materials are extracted, namely: weighing all medicinal materials in specified amount, adding water according to a ratio for soaking, decocting, filtering, decocting filter residues again, filtering, combining two water decoctions, concentrating, drying and crushing to obtain fine powder, measuring the content of active ingredients by an HPLC method, only detecting the active ingredients of chlorogenic acid and forsythiaside A, not detecting astin in the glabrous greenbrier rhizome, decocting the glabrous greenbrier rhizome separately, soaking for 30min by using 8 times of water by weight, decocting for 60min for the first time, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, combining two water decoctions, concentrating to the ratio of 1:1, adding the dandelion, the weeping forsythia and the prepared rehmannia root when other medicinal materials are decocted for 10-20min, specifically adding the loquat leaves, the mulberry leaves and the honeysuckle, decocting for 30min by using 8 times of water by weight, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, mixing the two water decoctions, concentrating to a ratio of 1:1, mixing rhizoma Smilacis Glabrae decoction and other medicinal material decoction, concentrating, drying, and determining content peaks of chlorogenic acid, forsythiaside A and astilbin by HPLC method, with the result meeting the specification.
Example 2: an effective traditional Chinese medicine composition for treating acne comprises the following raw material medicines in parts by weight: 45 parts of glabrous greenbrier rhizome, 20 parts of dandelion, 20 parts of weeping forsythia, 15 parts of loquat leaf, 15 parts of mulberry leaf, 15 parts of honeysuckle, 20 parts of black bean and 15 parts of prepared rehmannia root; in the formula, the glabrous greenbrier rhizome, the dandelion and the weeping forsythia have the effects of relieving muscles and eliminating sore toxin and guiding the medicine to skin, the loquat leaf, the mulberry leaf and the honeysuckle mainly have the effects of dispelling wind, clearing away the lung-heat, clearing away heat and promoting the production of body fluid, the black bean and the prepared rehmannia root mainly have the effects of promoting diuresis and removing dampness, and the preparation method of the effective traditional Chinese medicine composition for treating acne comprises the following preparation steps: 1) Weighing rhizoma Smilacis Glabrae; 2) proportioning rhizoma smilacis glabrae and water, and soaking to obtain a mixture A; 3) decocting the mixture A in the step 2), and filtering to obtain a first main filtrate B and a first filter residue C; 4) adding water into the first filter residue C obtained in the step 3), decocting and filtering to obtain a first filtrate D; 5) combining the first main filtrate B in the step 3) and the first primary filtrate D in the step 4), and performing rotary concentration to obtain a rhizoma smilacis glabrae concentrated solution E; 6) weighing dandelion, fructus forsythiae, loquat leaves, mulberry leaves, honeysuckle, black beans and prepared rehmannia roots, adding water, and decocting to obtain a second main filtrate F and a second filter residue G; 7) adding water into the second filter residue G obtained in the step 6), decocting and filtering to obtain a second filtrate H; 8) combining the second main filtrate F and the second filtrate H, rotating and concentrating to obtain a concentrated solution I; 9) mixing rhizoma Smilacis Glabrae concentrate E and concentrate I, drying, and pulverizing into fine powder; making into granule, capsule, tablet or oral preparation. 10) Sieving the fine powder; 11) weighing a certain weight part of starch, and sieving; 12) mixing the fine powder obtained in step 10)Fully mixing with the starch in the step 11), then dripping ethanol, uniformly mixing to prepare a soft material, then sieving, granulating, drying and finishing granules to obtain a granular preparation, wherein the traditional Chinese medicinal materials are prepared into the granular preparation according to the formula, so that the traditional Chinese medicinal decoction pieces are ensured to have accurate curative effect and complete components, and compared with the traditional Chinese medicinal administration mode, the traditional Chinese medicinal decoction pieces have the following advantages: decocting, boiling and the like, the granular preparation greatly changes the situation of fussy traditional Chinese medicine taking method, promotes the development of traditional Chinese medicine taking mode, and further comprises the steps of weighing 45 parts of glabrous greenbrier rhizome in step 1) and weighing the glabrous greenbrier rhizome in step 2) according to the weight ratio of the glabrous greenbrier rhizome: adding water according to the weight ratio of water =1:8, and soaking for 30 min; decocting the mixture A in the step 3) for 60min and filtering; adding water which is 8 times of the weight of the filter residue into the first filter residue C in the step 4) and decocting for 30 min; rotationally concentrating to a ratio of 1:1 in step 5), wherein the first main filtrate B and the first primary filtrate D are combined and then use a rotary evaporator at a rotation speed of 100 r.min-1Concentrating at 80 ℃ to the ratio of 1: 1; weighing 20 parts of dandelion, 20 parts of fructus forsythiae, 20 parts of black beans and 15 parts of prepared rehmannia roots in the step 6), adding 960 parts of water for decoction, and adding 15 parts of loquat leaves, 15 parts of mulberry leaves and 15 parts of honeysuckle into the mixture during decoction for 60min, wherein the water can be added during decoction for 10-20 min; in the step 7), adding the second filter residue G into water in an amount which is 8 times of the weight of the second filter residue G, decocting and filtering for 30min, and filtering; rotating and concentrating to the ratio of 1:1 in the step 8); drying by adopting a vacuum box in the step 9); sieving the fine powder with a 80-mesh sieve in the step 10); in the step 11), the weight part of the starch is 3-5 times of that of the fine powder in the step 10), and the starch passes through a 80-mesh sieve; and step 12) fully mixing the fine powder and starch according to an isometric incremental proportioning method, dripping 85% ethanol, uniformly mixing to prepare a soft material, achieving the purposes of finger holding and conglobation, dispersing by light pressure, and granulating by a 20-mesh nylon sieve. Or taking 30.50 g of fine powder, and enabling the fine powder to pass through a 80-mesh sieve, wherein the weight ratio of the dried fine powder: and (3) taking the dried fine powder, adding 131.15 g of starch which passes through a 80-mesh sieve, fully mixing the fine powder and the starch according to an equal-volume progressive addition method, adding 85% ethanol dropwise, uniformly mixing to prepare a soft material, so as to achieve the purposes of 'holding fingers to form a mass, dispersing by light pressure', sieving through a 20-mesh sieve, granulating, drying and finishing. Mixing beta-cyclodextrin as adjuvant with the fine powder, granulating, and wetting agent 85% ethanol, and inspecting the obtained granule to obtain the resultThe prepared granules do not meet the requirements of Chinese pharmacopoeia (2015 edition) on granules, the granules are not formed, starch replaces beta-cyclodextrin to carry out prescription process discussion again, medicinal specification soluble starch and beta-cyclodextrin (Tianjin, Mimi European chemical reagent Co., Ltd.) are optimized for the proportion of fine powder and starch, and the fine powder is found: starch =1:1 moisture-absorbing, fine powder: the proportion of the starch is changed into 1:2 granulation, and the prepared granules have poor appearance and properties and do not meet the specification. Finally, the fine powder: the starch ratio is set as 1:4.3, using 85% ethanol to pelletize, checking the prepared granules to meet the regulations, and then extracting effective components from various traditional Chinese medicinal materials by adopting a traditional water decoction method, namely: weighing all medicinal materials in specified amount, adding water according to a ratio for soaking, decocting, filtering, decocting filter residues again, filtering, combining two water decoctions, concentrating, drying and crushing to obtain fine powder, measuring the content of active ingredients by an HPLC method, only detecting the active ingredients of chlorogenic acid and forsythiaside A, not detecting astin in the glabrous greenbrier rhizome, decocting the glabrous greenbrier rhizome separately, soaking for 30min by using 8 times of water by weight, decocting for 60min for the first time, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, combining two water decoctions, concentrating to the ratio of 1:1, adding the dandelion, the weeping forsythia and the prepared rehmannia root when other medicinal materials are decocted for 10-20min, specifically adding the loquat leaves, the mulberry leaves and the honeysuckle, decocting for 30min by using 8 times of water by weight, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, mixing the two water decoctions, concentrating to a ratio of 1:1, mixing rhizoma Smilacis Glabrae decoction and other medicinal material decoction, concentrating, drying, and determining content peaks of chlorogenic acid, forsythiaside A and astilbin by HPLC method, with the result meeting the specification.
Example 3: a traditional Chinese medicine composition for effectively treating acne comprises the following raw material medicines in parts by weight: 50 parts of glabrous greenbrier rhizome, 25 parts of dandelion, 20 parts of weeping forsythia, 20 parts of loquat leaf, 20 parts of mulberry leaf, 20 parts of honeysuckle, 25 parts of black bean and 20 parts of prepared rehmannia root; in the formula, the glabrous greenbrier rhizome, the dandelion and the weeping forsythia have the effects of relieving muscles and eliminating sore toxin and guiding the medicine to skin, the loquat leaf, the mulberry leaf and the honeysuckle mainly have the effects of dispelling wind, clearing away the lung-heat, clearing away heat and promoting the production of body fluid, the black bean and the prepared rehmannia root mainly have the effects of promoting diuresis and removing dampness, and the preparation method of the effective traditional Chinese medicine composition for treating acne comprises the following preparation steps: 1) Weighing rhizoma Smilacis Glabrae; 2) proportioning rhizoma smilacis glabrae and water, and soaking to obtain a mixture A; 3) decocting the mixture A in the step 2), and filtering to obtain a first main filtrate B and a first filter residue C; 4) adding water into the first filter residue C obtained in the step 3), decocting and filtering to obtain a first filtrate D; 5) combining the first main filtrate B in the step 3) and the first primary filtrate D in the step 4), and performing rotary concentration to obtain a rhizoma smilacis glabrae concentrated solution E; 6) weighing dandelion, fructus forsythiae, loquat leaves, mulberry leaves, honeysuckle, black beans and prepared rehmannia roots, adding water, and decocting to obtain a second main filtrate F and a second filter residue G; 7) adding water into the second filter residue G obtained in the step 6), decocting and filtering to obtain a second filtrate H; 8) combining the second main filtrate F and the second filtrate H, rotating and concentrating to obtain a concentrated solution I; 9) mixing rhizoma Smilacis Glabrae concentrate E and concentrate I, drying, and pulverizing into fine powder; making into granule, capsule, tablet or oral preparation. 10) Sieving the fine powder; 11) weighing a certain weight part of starch, and sieving; 12) fully mixing the fine powder in the step 10) with the starch in the step 11), then dripping ethanol and uniformly mixing to prepare a soft material, and then sieving, granulating, drying and finishing. The granular preparation is obtained, the traditional Chinese medicinal materials are prepared into granules according to the formula, the accurate curative effect and complete components of the original traditional Chinese medicinal decoction pieces are ensured, and simultaneously, compared with the traditional Chinese medicine, the traditional Chinese medicine has the following administration mode: decocting, boiling and the like, the granular preparation greatly changes the situation of fussy traditional Chinese medicine taking method, 50 parts of glabrous greenbrier rhizome are weighed in the further step 1), and the weight of the glabrous greenbrier rhizome is calculated according to the following steps: adding water according to the weight ratio of water =1:8, and soaking for 30 min; decocting the mixture A in the step 3) for 60min and filtering; adding water which is 8 times of the weight of the filter residue into the first filter residue C in the step 4) and decocting for 30 min; rotationally concentrating to the ratio of 1:1 in the step 5), wherein the first main filtrate B and the first primary filtrate D are combined and then concentrated to the ratio of 1:1 by using a rotary evaporator at the rotating speed of 100 r.min-1 and the temperature of 80 ℃; step 6), weighing 25 parts of dandelion, 20 parts of fructus forsythiae, 25 parts of black beans and 20 parts of prepared rehmannia roots, adding 120 parts of water for decoction, specifically adding 20 parts of loquat leaves, 20 parts of mulberry leaves and 20 parts of honeysuckle into the mixture during decoction for 10-20min, and decocting for 60 min; in the step 7), adding the second filter residue G into water in an amount which is 8 times of the weight of the second filter residue G, decocting and filtering for 30min, and filtering; rotating and concentrating to the ratio of 1:1 in the step 8); drying by adopting a vacuum box in the step 9); sieving the fine powder with a 80-mesh sieve in the step 10); in the step 11), the weight part of the starch is 3-5 times of that of the fine powder in the step 10), and the starch passes through a 80-mesh sieve; and step 12) fully mixing the fine powder and starch according to an isometric incremental proportioning method, dripping 85% ethanol, uniformly mixing to prepare a soft material, achieving the purposes of finger holding and conglobation, dispersing by light pressure, and granulating by a 20-mesh nylon sieve. If a traditional water decoction method is adopted, the effective components in various traditional Chinese medicinal materials are extracted, namely: weighing all medicinal materials in specified amount, adding water according to a ratio for soaking, decocting, filtering, decocting filter residues again, filtering, combining two water decoctions, concentrating, drying and crushing to obtain fine powder, measuring the content of active ingredients by an HPLC method, only detecting the active ingredients of chlorogenic acid and forsythiaside A, not detecting astin in the glabrous greenbrier rhizome, decocting the glabrous greenbrier rhizome separately, soaking for 30min by using 8 times of water by weight, decocting for 60min for the first time, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, combining two water decoctions, concentrating to the ratio of 1:1, adding the dandelion, the weeping forsythia and the prepared rehmannia root when other medicinal materials are decocted for 10-20min, specifically adding the loquat leaves, the mulberry leaves and the honeysuckle, decocting for 30min by using 8 times of water by weight, filtering, adding 8 times of water by weight for filter residues, decocting for 30min again, filtering, mixing the two water decoctions, concentrating to a ratio of 1:1, mixing rhizoma Smilacis Glabrae decoction and other medicinal material decoction, concentrating, drying, and determining contents of chlorogenic acid, forsythiaside A and astilbin by HPLC method, with the result meeting the specification.
1. The medication mechanism is as follows: acne is generally difficult to cure radically by adopting a western medicine method at present. In traditional Chinese medicine, the human body is regarded as an organic whole, and the treatment is overall syndrome differentiation and treatment, which is the essence of traditional Chinese medicine and is also the characteristic of traditional Chinese medicine for treating acne. The prescription starts with the disease at all. Based on the traditional theory of wind-heat, lung-heat and blood-heat, the theory proposes the viewpoints of blood stasis, damp-heat, phlegm accumulation, kidney deficiency and the like. The formula of the research is based on the wind, lung, spleen and stomach, liver and Chong and ren theory, and can treat acne, treat symptoms and root causes and prevent recurrent attacks of diseases. According to the clinical curative effect result, the prescription has obvious curative effect on the acne. Meanwhile, the traditional Chinese medicinal materials are prepared into granules according to the formula, so that the situation that the traditional Chinese medicine preparation is complicated to take is changed, in the embodiment, the granular medicine is provided, and as a changeable implementation mode, the medicine can be prepared into granules, tablets, capsules, water pills, honeyed pills and water aqua through a conventional preparation method.
2. The experimental process comprises the following steps:
eight traditional Chinese medicinal materials of glabrous greenbrier rhizome, dandelion, weeping forsythia, loquat leaf, mulberry leaf, honeysuckle, black bean and prepared rehmannia root are purchased from Zhang Zhongjing large pharmacy in Kangshi city in Henan province. Identified by professor Likini, college of pharmacy of Henan university. Laboratory for existing specimen in eucommia ulmoides cultivation and Henan province utilization labor engineering
An electronic balance LT502E (evergreen city Tiandu instrument, Inc.), a rotary evaporator R-1005 (Zhengzhou Changchengchun Kogyo Co., Ltd.), a multipurpose vacuum pump SHB-3 (Xiaoyi Hezhong instrument supply station in Jiangzhou), a vacuum drying oven YLD-2000 (Zhengzhou Changchengchengchun Kogyo Co., Ltd.), a Shimadzu LC-10AT high performance liquid chromatograph (Shimadzu corporation, China Co., Ltd.), and an ultrasonic cleaner SB-5200 DTDN (Ningbo Xingzi Biotechnology, Ltd.).
Chlorogenic acid as reference (purity more than 99%, batch number: DST171117-21, Doudsite biotechnology, Inc.); astilbin (purity is more than or equal to 99%, batch number: DST161012-054, Chengdu Desite biotechnology limited); forsythoside A (purity is more than or equal to 98%, batch number: 11180-; chromatographically pure methanol and glacial acetic acid (Tianjin Shinyou Excellent technology Co., Ltd.).
2.1 chromatographic conditions
Column Thermo BDS HPERSIL C18 (250 mm. times.4.6 mm,5 μm); mobile phase: acetonitrile-0.1% glacial acetic acid solution (15: 85); the detection wavelength is 327nm (0-15 min) and 290nm (15-30 min); flow rate: 1.0mL min-1; column temperature: at 30 ℃.
2.2 preparation of control solutions
Precisely weighing 1.600mg chlorogenic acid standard, 1.500mg forsythoside A standard, and 0.100mg astilbin standard, placing in 2 mL volumetric flask, adding methanol to desired volume to obtain chlorogenic acid (concentration 0.80 g.L)-1) Forsythoside A (concentration 0.75 g.L)-1) Astilbin (concentration 0.050 g.L)-1) The mixed control solution of (4) was filtered through a 0.22 μm filter membrane for use.
2.3 preparation of test solutions
4g of the powder obtained by the whole particles in the example 2 is taken, ground to be capable of passing through a No. two sieve, added with 10 mL of purified water, ultrasonically vibrated for 30min to be fully dissolved, transferred and dissolved in a 10 mL volumetric flask, and filtered by using a 0.22 mu m filter membrane for standby.
2.4 Linear relationship investigation
Precisely sucking 1, 2, 4, 6, 8, 10, 12 μ L of the above control solution, and respectively injecting to determine the content of chlorogenic acid control sample corresponding to 0.8, 1.6, 3.2, 4.8, 6.4, 8.0, 9.6 μ g, forsythoside A control sample corresponding to 0.75, 1.5, 3.0, 4.5, 6.0, 7.5, 9.0 μ g, and astilbin control sample corresponding to 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6 μ g. Injecting into a high performance liquid chromatograph to determine peak area under each sampling amount. The horizontal coordinate is the reference substance amount (mug), the vertical coordinate is the peak area of the chromatographic peak, and the regression equation of the standard curve can be obtained: chlorogenic acid: y =2 200 060 060. 43X-51 333 333. 40 (R2=0.999 5); forsythoside A: y =1 035 457 457. 54X +10 667 667. 07(R2=0.999 2); astilbin: y =2 441 945 945. 71X-19 466 466. 67 (R2=0.999 1).
2.5 precision test
The prepared sample solution is continuously injected for 6 times, the chromatogram results of each time are recorded, and the peak area RSD% =0.31% of chlorogenic acid, the peak area RSD% = 0.30% of forsythiaside A and the peak area RSD% = 0.32% of astilbin can be obtained by calculating and analyzing data, so that the precision of the used instrument is good.
2.6 stability
Taking the same sample solution under item 2.3, injecting samples at 0, 2, 4, 6, 8, 10, 12, 16, 20 and 24 h respectively, and recording peak areas. Results RSD of the peak areas of the 3 components were 1.08%, 0.89%, 1.27% (n = 10), respectively, indicating that the test solution was stable within 24 h.
2.7 repeatability
6 parts of the prepared granule sample are taken, prepared in parallel according to the method and measured. As a result, the RSD values of the chlorogenic acid, the forsythoside A and the astilbin are 0.73%, 0.81% and 1.04% (n = 6), which indicates that the method has good repeatability.
2.8 sample recovery test
Adding a mixed standard substance reference substance into the anti-acne granules with known content according to a ratio of 1:1, respectively injecting samples according to the chromatographic conditions under the item of 2.1, and injecting sample amount: 10 uL, recording chromatogram, measuring, and indicating that the average recovery rate is as follows: chlorogenic acid 99.28%, forsythoside A99.36%, astilbin 99.41%.
2.9 determination of chlorogenic acid, forsythoside A, astilbin content
Taking 6 μ L of each of the reference substance and the sample solution, injecting into a liquid chromatograph, analyzing and measuring according to the above chromatographic conditions, and recording its high performance liquid chromatogram, as shown in FIG. 1 and FIG. 2.
3. Results of clinical efficacy test
In order to evaluate the influence effect of the traditional Chinese medicine composition on acne, the following experimental examples are divided into groups:
each group has 20 people in spring and summer, and the ratio of male to female is 1:0.8-1.2
The inclusion criteria of cases were: the skin damage is mainly the sporadic blackhead acne, inflammatory papule, pustule, nodule and cyst which affect the face, and the acne is confirmed by preliminarily making reference to the classification and curative effect standard of the skin cosmetology group of the aesthetic and aesthetic scores of Chinese medicine.
Exclusion criteria for cases: patients who had used antibiotics systemically within 0.5 month, or patients with liver and kidney disease; either women in pregnancy or lactation or patients with poor compliance who cannot be reviewed regularly.
The treatment method comprises the following steps:
the granules of the present invention (example 2) prepared according to example 1 were administered to each group twice a day with water in the morning and evening.
Each treatment course in the two groups is 2 weeks, and the life of the treatment period is regular and does not stay up all night; pungent, greasy and fishy foods are prohibited; avoid smoking and drinking, regulate emotion and keep mood stable.
The curative effect standard is as follows:
and (3) healing: the rash subsides by more than 90 percent, or only a little pigmentation is left, and the symptoms disappear;
has obvious effect that the rash is faded by 60 to 89 percent, and the symptoms are obviously relieved;
effectively, the skin damage is reduced by 30 to 59 percent, and the symptoms are obviously improved;
ineffective, the rash subsided less than 30%, or the clinical symptoms worsened in return.
As a result: after 2 weeks of treatment, 9 cases, 6 cases with obvious effect, 4 cases with effect and 1 case with no effect are cured in 20 cases of clinical experiments in summer, the cure rate is 45.00 percent, the total effective rate is 95.00 percent, and 8 cases, 9 cases with obvious effect, 3 cases with effect and 0 case with no effect, the cure rate is 40.00 percent and the total effective rate is 100.00 percent are cured in 20 cases of clinical experiments in autumn after 2 weeks of treatment. See table 5 (clinical efficacy results).
The above experiments were repeated in spring and summer.
The experiments show that the medicine prepared by the invention can safely and effectively treat acne and has good medical popularization value.
In conclusion, the traditional Chinese medicine composition has a good treatment effect on acne, the total effective rate is 97.5%, relapse is not easy to occur after healing, and the traditional Chinese medicine composition has no toxic or side effect and wide application value.
| Number of examples | Recovery method | Show effect | Is effective | Invalidation | Total effective | |
| Clinical in |
20 | 9 | 6 | 4 | 1 | 95 |
| |
20 | 8 | 9 | 3 | 0 | 100 |
TABLE 5
The concrete cases are as follows:
1. old man, 21 years old, students, facial red and swollen obviously on both cheeks, papules, accompanied by pain and slight itching. After 2 weeks, the facial acne and swelling basically subside, and the pain and the pruritus disappear after taking the medicine of the invention in the embodiment 1. The healing is complete.
2. Zhao, male, 22 years old, students repeatedly developed facial whelks for over 1 year, developed acne on the cheeks and chin, obvious red swelling, severe papules and pustules, white pus cells on the tops, pain and itching. After 2 weeks of taking the medicine of the embodiment 1 of the invention, facial acne is obviously improved, white heads disappear, pain and pruritus disappear, and the curative effect is very obvious after the medicine is continuously taken for 1 week.
3. Yi in Yi in women, 25 years old, students, facial acne mainly on the cheek side and forehead, red swelling is obvious, seborrhea is serious, the top is white and pus cell, accompanied by pain and slight itching. After 2 treatment courses of taking the medicine of the embodiment 1 of the invention, the facial acne red and swollen, pain and pruritus disappear and are cured.
The above embodiments are only preferred embodiments of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may change or modify the technical content disclosed above into equivalent embodiments with equivalent changes, but all those simple modifications, equivalent changes and modifications made on the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating acne is characterized by comprising the following raw material medicines in parts by weight: 40-50 parts of rhizoma smilacis glabrae, 15-25 parts of dandelion, 15-20 parts of fructus forsythiae, 10-20 parts of folium eriobotryae, 10-20 parts of folium mori, 10-20 parts of honeysuckle, 15-25 parts of black beans and 10-20 parts of prepared rehmannia roots.
2. The traditional Chinese medicine composition for treating acne according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 45 parts of glabrous greenbrier rhizome, 20 parts of dandelion, 20 parts of weeping forsythia, 15 parts of loquat leaf, 15 parts of mulberry leaf, 15 parts of honeysuckle, 20 parts of black bean and 15 parts of prepared rehmannia root.
3. A method for preparing a Chinese medicinal composition for treating acne according to claim 1, comprising the following steps:
1) weighing rhizoma Smilacis Glabrae;
2) proportioning the glabrous greenbrier rhizome in the step 1) and water, and soaking to obtain a mixture A;
3) decocting the mixture A in the step 2), and filtering to obtain a first main filtrate B and a first filter residue C;
4) adding water into the first filter residue C obtained in the step 3), decocting and filtering to obtain a first filtrate D;
5) combining the first main filtrate B in the step 3) and the first primary filtrate D in the step 4), and performing rotary concentration to obtain a rhizoma smilacis glabrae concentrated solution E;
6) weighing dandelion, fructus forsythiae, loquat leaves, mulberry leaves, honeysuckle, black beans and prepared rehmannia roots, adding water, and decocting to obtain a second main filtrate F and a second filter residue G;
7) adding water into the second filter residue G obtained in the step 6), decocting and filtering to obtain a second filtrate H;
8) combining the second main filtrate F and the second filtrate H, rotating and concentrating to obtain a concentrated solution I;
9) mixing rhizoma Smilacis Glabrae concentrate E and concentrate I, drying, and pulverizing into fine powder;
10) sieving the fine powder;
11) weighing a certain weight part of starch, and sieving;
12) fully mixing the fine powder in the step 10) with the starch in the step 11), then dripping ethanol and uniformly mixing to prepare a soft material, and then sieving, granulating, drying and finishing.
4. The preparation method of the traditional Chinese medicine composition for treating acne according to claim 3, characterized in that 45 parts of rhizoma smilacis glabrae are weighed in the step 1), and the ratio of rhizoma smilacis glabrae to rhizoma smilacis glabrae in the step 2) is determined according to the ratio of rhizoma smilacis glabrae: adding water according to the weight ratio of water =1:8, and soaking for 30 min; decocting the mixture A in the step 3) for 60min, and filtering.
5. The preparation method of the traditional Chinese medicine composition for treating acne according to claim 3, characterized in that the first filter residue C in the step 4) is added with water 8 times of the weight of the filter residue and decocted for 30 min; the step 5) is carried out rotary concentration until the ratio is 1: 1.
6. The method for preparing a Chinese medicinal composition for treating acne according to claim 3, wherein 20 parts of dandelion, 20 parts of forsythia suspensa, 20 parts of black bean and 15 parts of prepared rehmannia root are weighed in step 6), 960 parts of water is added for decoction, and 15 parts of loquat leaves, 15 parts of mulberry leaves and 15 parts of honeysuckle are added in the decoction process for 60 min.
7. The method for preparing a Chinese medicinal composition for treating acne according to claim 3, wherein in step 7), the second residue G is added into 8 times of water by weight of the second residue G, and decocted for 30min and filtered; rotating and concentrating to the ratio of 1:1 in the step 8); drying by adopting a vacuum box in the step 9); in the step 10), the fine powder is sieved by a sieve with 80 meshes.
8. The method for preparing a Chinese medicinal composition for treating acne according to claim 3, wherein the weight part of starch in step 11) is 3-5 times that of the fine powder in step 10), and the starch passes through a 80-mesh sieve; and step 12) fully mixing the fine powder and starch according to an isometric incremental proportioning method, dripping 85% ethanol, uniformly mixing to prepare a soft material, achieving the purposes of finger holding and conglobation, dispersing by light pressure, and granulating by a 20-mesh nylon sieve.
9. The preparation method of the traditional Chinese medicine composition for treating acne according to claim 3, characterized by comprising the following steps: the fine powder is prepared into granules, capsules or tablets.
10. The preparation method of the traditional Chinese medicine composition for treating acne according to claim 3, characterized by comprising the following steps: combining the first main filtrate B and the first primary filtrate D in the step 5), and then using a rotary evaporator at the rotating speed of 100 r.min-1Concentrating at 80 deg.C to a ratio of 1: 1.
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| 浅议黑豆美容的古今应用;陈少丽等;《辽宁中医学院学报》;20050918;第7卷(第05期);第503-504页 * |
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