CN1973853B - Hemostatic and analgetic medicine composition and its preparation process - Google Patents
Hemostatic and analgetic medicine composition and its preparation process Download PDFInfo
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- CN1973853B CN1973853B CN2006101403861A CN200610140386A CN1973853B CN 1973853 B CN1973853 B CN 1973853B CN 2006101403861 A CN2006101403861 A CN 2006101403861A CN 200610140386 A CN200610140386 A CN 200610140386A CN 1973853 B CN1973853 B CN 1973853B
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Abstract
The present invention discloses one kind of hemostatic and analgetic medicine composition and its preparation process. The medicine composition is prepared with common lamiophlomis root extract and notoginseng total saponin as main components and has pharmaceutically acceptable excipient added. It is prepared into different clinical preparation forms, including capsule, plaster, injection, bolus, tablet, etc. It has the functions of promoting blood circulation to disperse blood clots, relieving pain and arresting bleeding.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly pharmaceutical composition of a kind of hemostatic analgesia and preparation method thereof.
Background technology
Wound, operation back congestive edema, pain, hemorrhage, rheumatalgia, very general clinically, and have a strong impact on health or comfort level, so also more to the drug research of only learning blood analgesia class both at home and abroad.Register and produce in the Chinese patent medicine of listing getting permission, cure mainly the outer kind that injures operation back congestive edema, pain and mainly contain: notoginseng capsule (sheet), raw sangqi ginseng loose, asiaticoside ointment, seven lis of capsules (loosing), ruyi jinhuang powder, ruyi jinhuang san, Rhizoma Corydalis Decumbentis tablet, WAISHANG RUYI GAO, cure the wound diffusing (capsule), pain relieving Zijin ball, marasmius androsaceus tincture, BAIYAO JIAONANG, white BAODAN, powder for trauma, pill for traumatic injuries (sheet), contusion tablet (loose, medicated wine), compound recipe Radix Notoginseng are diffusing, FUFANG DANGGUI ZHUSHEYE, Radix Lamiophlomidis Rotatae capsule (sheet), Sanguis Draxonis capsule, HUOXUE ZHIRONG JIAONANG (loosing), notoginseng injury tablet etc.Curing mainly the outer kind that injures wound bleeding mainly contains: compound recipe Herba Acalyphae styptic powder, the new liquid of rehabilitation, Radix Notoginseng blood are hindered Yiganning capsule (loosing), Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) sheet, Radix Notoginseng hemostasis hemostatic beautyberry liquid etc.
Though above product has kind more than 100, the double kind of controlling congestive edema and wound bleeding only have Radix Lamiophlomidis Rotatae capsule (sheet), Radix Notoginseng Tabellae etc. a few.This a few medicine also all has laying particular stress on separately, or biases toward hemostasis, or biases toward analgesia, and is the direct extract of medical material and is used as medicine, and extract is not separated targetedly.The medicine that does not have at present a kind of effective site that hemostasis, analgesia are laid equal stress on to be used as medicine as yet with extract drugs.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition and formulation preparation method thereof, and another purpose of the present invention is to provide the purposes of this drug combination preparation.Another purpose of the present invention is to provide a kind of Radix Lamiophlomidis Rotatae extract and uses thereof.
The present invention seeks to be achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention is composed as follows:
Radix Lamiophlomidis Rotatae extract 10-90 weight portion Radix Notoginseng total arasaponins 10-90 weight portion.
The preferred weight proportioning of the present invention's two flavor crude drug is as follows:
Radix Lamiophlomidis Rotatae extract 12-30 weight portion Radix Notoginseng total arasaponins 65-85 weight portion;
Radix Lamiophlomidis Rotatae extract 65-85 weight portion Radix Notoginseng total arasaponins 12-30 weight portion;
Radix Lamiophlomidis Rotatae extract 20 weight portion Radix Notoginseng total arasaponinss 80 weight portions;
Radix Lamiophlomidis Rotatae extract 30 weight portion Radix Notoginseng total arasaponinss 70 weight portions;
Radix Lamiophlomidis Rotatae extract 50 weight portion Radix Notoginseng total arasaponinss 50 weight portions;
Radix Lamiophlomidis Rotatae extract 70 weight portion Radix Notoginseng total arasaponinss, 30 weight portions or
Radix Lamiophlomidis Rotatae extract 80 weight portion Radix Notoginseng total arasaponinss 20 weight portions.
Radix Lamiophlomidis Rotatae extract of the present invention can prepare according to a conventional method also and can prepare as follows:
Method one: get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, put in the percolator, 70% soak with ethanol is spent the night, percolation, and percolate is concentrated into extractum, extractum is with 1-2 times of water gaging suspendible, and with 0.5-2 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 1-3 time, the extraction remainder is a water section successively; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; Gained n-butyl alcohol part extractum through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% with pure water system, and 50%, 70%, 90% ethanol is gradient elution respectively, reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract of the present invention.
Method two: get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, decoct with water three times, merge aqueous extract, filter, with 0.5-2 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 1-3 time, the extraction remainder is a water section to filtrate successively; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; The water section of gained through macroporous resin adsorption post (AB-8), is pressed water, 10%, 30% respectively with pure water system, and 50%, 70%, 90% ethanol gradient elution reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract of the present invention.
Traditional Chinese medicinal composition raw materials of the present invention adds conventional adjuvant, according to common process, makes clinical acceptable forms, as: capsule, cataplasma, injection, pill, tablet or granule.
Pharmaceutical composition of the present invention can prepare according to a conventional method also and can prepare as follows:
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 8-12 multiple proportions example that extracting solution is adsorbed, with resin ratio 8-12 times water consumption resin is carried out remove impurity, with resin demand 2-4 times concentration is that the alcoholic solution of 25%-35% carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule, cataplasma, injection, pill, tablet or granule according to the conventional formulation method.
Pharmaceutical composition of the present invention can prepare according to a conventional method also and can prepare as follows:
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 10 multiple proportions examples that extracting solution is adsorbed, with 10 times of water consumptions of resin ratio resin is carried out remove impurity, with 3 times of concentration of resin demand is that 30% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule according to the conventional formulation method.
Crude drug of the present invention preferably wherein contains total flavones and cyclenes ether card and is not less than 50% Radix Lamiophlomidis Rotatae extract; Crude drug of the present invention preferably meet national standard commercially available Radix Notoginseng total arasaponins.
The pass of weight portion parts by volume of the present invention is g/ml.
Pharmaceutical composition of the present invention has promoting blood circulation and stopping pain, and the effect of removing stasis to stop bleeding can be used for the edge of a knife pain, hemorrhage behind the surgical operation, exogenous injury, and muscles and bones is sprained, rheumatic arthralgia and metrorrhagia, dysmenorrhea, gingival swelling and pain, hemorrhage treatment.
Following experiment and embodiment are used to further specify but are not limited to the present invention.
The screening experiment of experimental example 1 Radix Lamiophlomidis Rotatae analgesia effective site
1. instrument and reagent
The purebred mice of ICR: Sichuan Industrial Institute of Antibiotics animal testing center
Macroporous adsorbent resin AB-8 type: Tianjin resin processing plant
Aspirin: commercially available
Ethanol, petroleum ether, ethyl acetate, n-butyl alcohol, acetic acid are analytical pure
2. method and result
2.1 the extraction of medical material and rough segmentation
Method one: get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, put in the percolator, 70% soak with ethanol is spent the night, percolation, and percolate is concentrated into extractum, and extractum is used petroleum ether, ethyl acetate, n-butanol extraction successively with the water suspendible, and the extraction remainder is a water section.Reclaim solvent to doing, get sample petroleum ether part A, ethyl acetate part B, n-butyl alcohol portion C, water section D.
Method two: get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, decoct with water three times, merge aqueous extract, filter, filtrate is used petroleum ether, ethyl acetate, n-butanol extraction successively, and the extraction remainder is a water section.Reclaim solvent to doing, get sample petroleum ether part E, ethyl acetate part F, n-butyl alcohol part G, water section H.
2.2 analgesia screening test 1
Get 72 of body weight (20 scholar 2g) ICR mices, male and female half and half, be divided into 10 groups at random, irritate stomach respectively and give 3%CMC-Na solution (model group), aspirin (300mg/kg), sample A (120mg/kg), sample B (28mg/kg). sample C (180mg/kg), sample D (480mg/kg), sample E (120mg/kg), sample F (28mg/kg). sample G (180mg/kg), sample H (480mg/kg).Behind the administration 1h, each organizes the mice acetum 10ml/kg of lumbar injection 6ml/L respectively, and to timing immediately behind the acetic acid, the record mice begins to turn round turns round the body number of times in body time and the 15min.Result of the test sees Table 1, and show sample C and sample H have significant analgesia role as a result.
Table 1 Radix Lamiophlomidis Rotatae gradient extract and separate position is to the influence ((n=12) of mice acetic acid twisting reaction
* compare with model group, P＜0.05, * * compares with model group, P＜0.01
2.3C the segmentation of part and H part
The water section of method one gained n-butyl alcohol part extractum and method two gained, respectively through macroporous resin adsorption post (AB-8), press water, 10% with pure water system, 30%, 50%, 70%, 90% difference gradient elution, eluent is through the thin layer chromatography inspection, merge similar part, reclaim solvent respectively, get the water section A of method one, 10% part and 30% part are merged into part B, remainder is merged into portion C. and the water section D of method two, 10% part and 30% part are merged into part E, remainder is merged into part F
2.4 analgesia screening II
Get 60 of body weight (20 scholar 2g) ICR mices, male and female half and half, be divided into 5 groups at random, irritate respectively after stomach gives 3%CMC-Na solution (model group), aspirin (300mg/kg), sample A (48mg/kg), sample B (82mg/kg), sample C (34mg/kg), sample D (48mg/kg), sample E (82mg/kg), sample F (34mg/kg) administration 1h, each organizes the mice acetum 10ml/kg of lumbar injection 6mlL respectively, to timing immediately behind the acetic acid, the record mice begins to turn round turns round the body number of times in body time and the 15min.Result of the test sees Table 2, and the result shows that the analgesic activity of the 30% ethanol elution part of two kinds of extracts is all more remarkable.
Table 2 n-butanol portion alcohol water system eluting each several part is to the influence ((n=12) of mice acetic acid twisting reaction
* compare with model group, P＜0.05, * * compares with model group, P＜0.01
The Synergistic experiment of experimental example 2 Radix Lamiophlomidis Rotatae extracts and notoginseng total saponin compounds
Analgesic test: mice acetic acid twisting method: get body weight (168 of 20 ± 2g) ICR mices, male and female half and half, be divided into 14 groups at random, irritate stomach respectively and give 3%CMC-Na solution (model group), sample I (0.3mg/kg). sample II (0.4mg/kg), sample III (0.5mg/kg), sample IV (0.6mg/kg), sample V (0.7mg/kg), sample VI (0.8mg/kg).Behind the administration 1h, each organizes respectively lumbar injection 6mL/L of mice, acetum 10mL/kg give timing immediately behind the acetic acid, the record mice begins to turn round turns round the body number of times in body time and the 15min.
Hemostasis trial: adopt capillary glass-tube method, the animal grouping is the same with administration, behind the administration 1h, insert the angular vein clump of mice with the glass capillary of internal diameter 1mm and get blood, autoblood flows to the pipe clocking internal, fills with the back glass capillary and lies against on the table, and one section in capillary tube fractureed every 30 seconds, and slowly draw back to the left and right, when the blood clotting silk occurring, count clotting time.
With above-mentioned two kinds of methods Radix Lamiophlomidis Rotatae extract and Radix Notoginseng extract (commercially available Radix Notoginseng total arasaponins) ratio of share are screened:
Test result's following (table 3) according to method one (percolation+polarity extraction+macroporous resin eluting) extraction Radix Lamiophlomidis Rotatae extract and Radix Notoginseng extract combination:
Table 3 Radix Lamiophlomidis Rotatae and Radix Notoginseng extract combination matching test of pesticide effectiveness result
Test result's following (table 4) according to method two (water is carried+polarity extraction+macroporous resin eluting) extraction Radix Lamiophlomidis Rotatae extract and Radix Notoginseng extract combination
Table 4 Radix Lamiophlomidis Rotatae and Radix Notoginseng extract combination matching test of pesticide effectiveness result
Data result by above table 3, table 4 shows that Radix Lamiophlomidis Rotatae extract uses with the Radix Notoginseng extract compatibility and compares with extract of independent use, all shows synergism in the analgesia test of pesticide effectiveness and the pain relieving test of pesticide effectiveness.
Wherein, Radix Lamiophlomidis Rotatae extract and Radix Notoginseng extract all showed good hemostasis, analgesic drug effect at 5: 5 to 9: 1 o'clock at formula proportion.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: the preparation of capsule
Radix Lamiophlomidis Rotatae extract 10kg Radix Notoginseng total arasaponins 90kg;
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 10 multiple proportions examples that extracting solution is adsorbed, with 10 times of water consumptions of resin ratio resin is carried out remove impurity, with 3 times of concentration of resin demand is that 30% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule according to the conventional formulation method.
Embodiment 2: the preparation of capsule
Radix Lamiophlomidis Rotatae extract 30kg Radix Notoginseng total arasaponins 70kg;
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 8 multiple proportions examples that extracting solution is adsorbed, with 10 times of water consumptions of resin ratio resin is carried out remove impurity, with 4 times of concentration of resin demand is that 30% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule according to the conventional formulation method.
Embodiment 3: the preparation of cataplasma
Radix Lamiophlomidis Rotatae extract 50kg Radix Notoginseng total arasaponins 50kg;
Add conventional adjuvant, make cataplasma according to a conventional method.
Embodiment 4: the preparation of injection
Radix Lamiophlomidis Rotatae extract 70kg Radix Notoginseng total arasaponins 30kg;
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 10 multiple proportions examples that extracting solution is adsorbed, with 12 times of water consumptions of resin ratio resin is carried out remove impurity, with 3 times of concentration of resin demand is that 35% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made injection according to the conventional formulation method.
Embodiment 5: the preparation of granule
Radix Lamiophlomidis Rotatae extract 90kg Radix Notoginseng total arasaponins 10kg;
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 12 multiple proportions examples that extracting solution is adsorbed, with 8 times of water consumptions of resin ratio resin is carried out remove impurity, with 3 times of concentration of resin demand is that 25% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made granule according to the conventional formulation method.
Embodiment 6: the preparation of tablet
Radix Lamiophlomidis Rotatae extract 40kg Radix Notoginseng total arasaponins 70kg;
Add conventional adjuvant, make tablet according to a conventional method.
Embodiment 7: the preparation of cataplasma
Radix Lamiophlomidis Rotatae extract 20kg Radix Notoginseng total arasaponins 80kg;
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, put in the percolator, 70% soak with ethanol is spent the night, percolation, and percolate is concentrated into extractum, extractum is with 1.5 times of water gaging suspendibles, uses 1 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction successively 2 times, and the extraction remainder is a water section; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; Gained n-butyl alcohol part extractum through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% with pure water system, and 50%, 70%, 90% ethanol is gradient elution respectively, reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract of the present invention; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, add conventional adjuvant, make cataplasma according to a conventional method.
Embodiment 8: the preparation of injection
Radix Lamiophlomidis Rotatae extract 80kg Radix Notoginseng total arasaponins 20kg;
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, decoct with water three times, merge aqueous extract, filter, filtrate is used 1 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 2 times successively, and the extraction remainder is a water section; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; The water section of gained through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% respectively with pure water system, and 50%, 70%, 90% ethanol gradient elution reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract of the present invention; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, add conventional adjuvant, make injection according to a conventional method.
Claims (11)
1. the pharmaceutical composition of a hemostatic analgesia is characterized in that the crude drug of this pharmaceutical composition consists of:
Radix Lamiophlomidis Rotatae extract 12-30 weight portion Radix Notoginseng total arasaponins 65-85 weight portion.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug weight proportion is as follows:
Radix Lamiophlomidis Rotatae extract 20 weight portion Radix Notoginseng total arasaponinss 80 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug weight proportion is as follows:
Radix Lamiophlomidis Rotatae extract 30 weight portion Radix Notoginseng total arasaponinss 70 weight portions.
4. as described any one preparation of drug combination method of claim 1-3, it is characterized in that this method is conventional method or following method:
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 8-12 multiple proportions example that extracting solution is adsorbed, with resin ratio 8-12 times water consumption resin is carried out remove impurity, with resin demand 2-4 times concentration is that the alcoholic solution of 25%-35% carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule, cataplasma, injection, pill, tablet or granule according to the conventional formulation method.
5. preparation of drug combination method as claimed in claim 4 is characterized in that this method is conventional method or following method:
The Radix Lamiophlomidis Rotatae medical material is according to the conventional method extracting in water, the water extract adopts the D101 type macroporous adsorbent resin that is equivalent to medical material 10 multiple proportions examples that extracting solution is adsorbed, with 10 times of water consumptions of resin ratio resin is carried out remove impurity, with 3 times of concentration of resin demand is that 30% alcoholic solution carries out eluting, collect eluent, drying is pulverized, and gets Radix Lamiophlomidis Rotatae extract; Merge in proportion with the Radix Notoginseng total arasaponins of buying on the market, the crude drug that is mixed into is made capsule according to the conventional formulation method.
6. as described any one pharmaceutical composition of claim 1-3, it is characterized in that Radix Lamiophlomidis Rotatae extract wherein prepares as follows:
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, put in the percolator, 70% soak with ethanol is spent the night, percolation, and percolate is concentrated into extractum, extractum is with 1-2 times of water gaging suspendible, and with 0.5-2 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 1-3 time, the extraction remainder is a water section successively; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; Gained n-butyl alcohol part extractum through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% with pure water system, and 50%, 70%, 90% ethanol is gradient elution respectively, reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract.
7. as described any one pharmaceutical composition of claim 1-3, it is characterized in that Radix Lamiophlomidis Rotatae extract wherein prepares as follows:
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, decoct with water three times, merge aqueous extract, filter, with 0.5-2 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 1-3 time, the extraction remainder is a water section to filtrate successively; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; The water section of gained through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% respectively with pure water system, and 50%, 70%, 90% ethanol gradient elution reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract.
8. pharmaceutical composition as claimed in claim 6 is characterized in that Radix Lamiophlomidis Rotatae extract wherein prepares as follows:
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, put in the percolator, 70% soak with ethanol is spent the night, percolation, and percolate is concentrated into extractum, extractum is with 1.5 times of water gaging suspendibles, uses 1 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction successively 2 times, and the extraction remainder is a water section; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; Gained n-butyl alcohol part extractum through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% with pure water system, and 50%, 70%, 90% ethanol is gradient elution respectively, reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract.
9. pharmaceutical composition as claimed in claim 7 is characterized in that Radix Lamiophlomidis Rotatae extract wherein prepares as follows:
Get dry Radix Lamiophlomidis Rotatae aerial parts, pulverize, decoct with water three times, merge aqueous extract, filter, filtrate is used 1 times of parts by volume petroleum ether, ethyl acetate, n-butanol extraction 2 times successively, and the extraction remainder is a water section; Reclaim solvent to doing, get sample petroleum ether part, ethyl acetate part, n-butyl alcohol part, water section; The water section of gained through macroporous resin adsorption post AB-8, is pressed water, 10%, 30% respectively with pure water system, and 50%, 70%, 90% ethanol gradient elution reclaims solvent respectively, and 10% part and 30% part merge, and gets Radix Lamiophlomidis Rotatae extract.
10. as the application of described any one pharmaceutical composition of claim 1-3 in the preparation haemostatic medicament.
11. as the application of described any one pharmaceutical composition of claim 1-3 in the preparation analgesic.
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| CN105521224A (en) * | 2016-02-22 | 2016-04-27 | 张丽瑛 | External traditional Chinese medicine formula for treating rheumatism |
| CN106138196B (en) * | 2016-08-24 | 2021-03-05 | 成都中医药大学附属医院 | Toothpaste containing pseudo-ginseng extract and lamiophlomis rotata extract and preparation method thereof |
| CN107174599B (en) * | 2017-06-19 | 2020-11-10 | 浩宇康宁健康科技（湖北）有限公司 | Hemostatic, anti-inflammatory and stasis-removing medicine, preparation method thereof and hemostatic, anti-inflammatory and stasis-removing band-aid containing same |
| CN108888769A (en) * | 2018-07-30 | 2018-11-27 | 郑州兰茜生物工程有限公司 | The biological agent that strengthening tendons are good for network function is used and had to a kind of neck-shoulder pain, lumbago and leg pain |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1712030A (en) * | 2004-06-21 | 2005-12-28 | 景明 | Preparation of Duyiwei medicine |
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| CN1712030A (en) * | 2004-06-21 | 2005-12-28 | 景明 | Preparation of Duyiwei medicine |
Non-Patent Citations (2)
| Title |
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| 张绪迎.挫伤性前房出血继发青光眼的治疗.职业与健康19 11.2003,19(11),144-145. * |
| 范健.醉酒后眼外伤临床分析报告.眼外伤职业病杂志25 7.2003,25(7),478. * |
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