CN109475543A - 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 - Google Patents

用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 Download PDF

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Publication number
CN109475543A
CN109475543A CN201780019895.5A CN201780019895A CN109475543A CN 109475543 A CN109475543 A CN 109475543A CN 201780019895 A CN201780019895 A CN 201780019895A CN 109475543 A CN109475543 A CN 109475543A
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CN
China
Prior art keywords
compound
day
method described
amount
treatment
Prior art date
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Pending
Application number
CN201780019895.5A
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English (en)
Chinese (zh)
Inventor
A·F·利斯特
D·A·塞尔曼
J·S·科瓦奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lee Moffitt Cancer Center and Research Institute Inc
Lixte Biotechnology Inc
Original Assignee
H Lee Moffitt Cancer Center and Research Institute Inc
Lixte Biotechnology Inc
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Application filed by H Lee Moffitt Cancer Center and Research Institute Inc, Lixte Biotechnology Inc filed Critical H Lee Moffitt Cancer Center and Research Institute Inc
Publication of CN109475543A publication Critical patent/CN109475543A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780019895.5A 2016-01-27 2017-01-27 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 Pending CN109475543A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662287858P 2016-01-27 2016-01-27
US62/287,858 2016-01-27
PCT/US2017/015237 WO2017132445A1 (en) 2016-01-27 2017-01-27 Clincal regimen for treating myelodysplastic syndrome with phosphatase inhibitor

Publications (1)

Publication Number Publication Date
CN109475543A true CN109475543A (zh) 2019-03-15

Family

ID=59398691

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780019895.5A Pending CN109475543A (zh) 2016-01-27 2017-01-27 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案

Country Status (6)

Country Link
US (2) US20190111053A1 (https=)
EP (1) EP3407887B1 (https=)
JP (1) JP6964593B2 (https=)
CN (1) CN109475543A (https=)
CA (1) CA3051828A1 (https=)
WO (1) WO2017132445A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160004299A (ko) 2013-04-09 2016-01-12 릭스트 바이오테크놀로지, 인코포레이티드 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형
ES2985668T3 (es) 2015-05-15 2024-11-06 Lixte Biotechnology Inc Profármacos de oxabicicloheptano para uso en el tratamiento del cáncer
WO2018027144A1 (en) * 2016-08-04 2018-02-08 H. Lee Moffitt Cancer Center And Research Institute Inc. Companion diagnostic for combination lenalidomide and erythropoietin treatment
EP4324477A3 (en) 2016-12-08 2024-05-22 Lixte Biotechnology, Inc. Oxabicycloheptanes for modulation of immune response

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150045373A1 (en) * 2007-02-06 2015-02-12 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
US20150224083A1 (en) * 2006-09-07 2015-08-13 Stemline Therapeutics, Inc. Cancer Therapy With Cantharidin And Cantharidin Analogs
WO2016014783A1 (en) * 2014-07-24 2016-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160004299A (ko) * 2013-04-09 2016-01-12 릭스트 바이오테크놀로지, 인코포레이티드 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형
WO2016040877A1 (en) * 2014-09-12 2016-03-17 Lixte Biotechnology, Inc. Human dosing of phosphatase inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150224083A1 (en) * 2006-09-07 2015-08-13 Stemline Therapeutics, Inc. Cancer Therapy With Cantharidin And Cantharidin Analogs
US20150045373A1 (en) * 2007-02-06 2015-02-12 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2016014783A1 (en) * 2014-07-24 2016-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes

Also Published As

Publication number Publication date
US20220184066A1 (en) 2022-06-16
JP2019507134A (ja) 2019-03-14
EP3407887A4 (en) 2019-09-25
WO2017132445A1 (en) 2017-08-03
US20190111053A1 (en) 2019-04-18
EP3407887B1 (en) 2021-09-01
JP6964593B2 (ja) 2021-11-10
CA3051828A1 (en) 2017-08-03
US20220323433A2 (en) 2022-10-13
EP3407887A1 (en) 2018-12-05
WO2017132445A8 (en) 2018-12-20

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Application publication date: 20190315