CN109475543A - 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 - Google Patents

用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 Download PDF

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Publication number
CN109475543A
CN109475543A CN201780019895.5A CN201780019895A CN109475543A CN 109475543 A CN109475543 A CN 109475543A CN 201780019895 A CN201780019895 A CN 201780019895A CN 109475543 A CN109475543 A CN 109475543A
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CN
China
Prior art keywords
compound
day
method described
amount
treatment
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Pending
Application number
CN201780019895.5A
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English (en)
Chinese (zh)
Inventor
A·F·利斯特
D·A·塞尔曼
J·S·科瓦奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lee Moffitt Cancer Center and Research Institute Inc
Lixte Biotechnology Inc
Original Assignee
H Lee Moffitt Cancer Center and Research Institute Inc
Lixte Biotechnology Inc
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Application filed by H Lee Moffitt Cancer Center and Research Institute Inc, Lixte Biotechnology Inc filed Critical H Lee Moffitt Cancer Center and Research Institute Inc
Publication of CN109475543A publication Critical patent/CN109475543A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780019895.5A 2016-01-27 2017-01-27 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案 Pending CN109475543A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662287858P 2016-01-27 2016-01-27
US62/287,858 2016-01-27
PCT/US2017/015237 WO2017132445A1 (en) 2016-01-27 2017-01-27 Clincal regimen for treating myelodysplastic syndrome with phosphatase inhibitor

Publications (1)

Publication Number Publication Date
CN109475543A true CN109475543A (zh) 2019-03-15

Family

ID=59398691

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780019895.5A Pending CN109475543A (zh) 2016-01-27 2017-01-27 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案

Country Status (6)

Country Link
US (2) US20190111053A1 (enExample)
EP (1) EP3407887B1 (enExample)
JP (1) JP6964593B2 (enExample)
CN (1) CN109475543A (enExample)
CA (1) CA3051828A1 (enExample)
WO (1) WO2017132445A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2909160C (en) 2013-04-09 2021-05-25 Lixte Biotechnology, Inc. Formulations of oxabicycloheptanes and oxabicycloheptenes
EP3736275B1 (en) 2015-05-15 2024-07-03 Lixte Biotechnology, Inc. Oxabicycloheptane prodrugs for use in treating cancer
US20190240290A1 (en) * 2016-08-04 2019-08-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Companion diagnostic for combination lenalidomide and erythropoietin treatment
JP7246309B2 (ja) 2016-12-08 2023-03-27 リクスト・バイオテクノロジー，インコーポレイテッド 免疫応答を調節するためのオキサビシクロヘプタン

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150045373A1 (en) * 2007-02-06 2015-02-12 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
US20150224083A1 (en) * 2006-09-07 2015-08-13 Stemline Therapeutics, Inc. Cancer Therapy With Cantharidin And Cantharidin Analogs
WO2016014783A1 (en) * 2014-07-24 2016-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2909160C (en) * 2013-04-09 2021-05-25 Lixte Biotechnology, Inc. Formulations of oxabicycloheptanes and oxabicycloheptenes
EP3191096A4 (en) * 2014-09-12 2018-03-21 Lixte Biotechnology, Inc. Human dosing of phosphatase inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150224083A1 (en) * 2006-09-07 2015-08-13 Stemline Therapeutics, Inc. Cancer Therapy With Cantharidin And Cantharidin Analogs
US20150045373A1 (en) * 2007-02-06 2015-02-12 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2016014783A1 (en) * 2014-07-24 2016-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes

Also Published As

Publication number Publication date
WO2017132445A8 (en) 2018-12-20
US20220184066A1 (en) 2022-06-16
JP6964593B2 (ja) 2021-11-10
US20220323433A2 (en) 2022-10-13
EP3407887A4 (en) 2019-09-25
JP2019507134A (ja) 2019-03-14
CA3051828A1 (en) 2017-08-03
EP3407887A1 (en) 2018-12-05
US20190111053A1 (en) 2019-04-18
EP3407887B1 (en) 2021-09-01
WO2017132445A1 (en) 2017-08-03

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Application publication date: 20190315