CN109464150A - A kind of non-intrusion type foetus brain blood oxygen detector device and its method - Google Patents
A kind of non-intrusion type foetus brain blood oxygen detector device and its method Download PDFInfo
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1464—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters specially adapted for foetal tissue
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Abstract
The invention discloses a kind of non-intrusion type foetus brain blood oxygen detector device and its methods, detecting instrument includes probe and control device, probe forms complete be bonded with her abdominal, probe is equipped with light emitting source and multiple sensitivity specks, the light that light emitting source is issued forms corresponding emergent light when walking to her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissue, and multiple sensitivity specks separately detect corresponding emergent light；Power module, light source driver module, sensitivity speck signal receiving module and the data disaply moudle for being equipped with central processing module in control device and being electrically connected with central processing module；Light source driver module controls light emitting source and shines, and sensitivity speck signal receiving module receives the photoreceptor signal of multiple sensitivity specks, obtains cerebral blood oxygen saturation value after central processing module carries out data processing, and show through data disaply moudle.The present invention uses noninvasive detection mode, can be used to evaluate foetus brain oxygen situation in time, prevents encephalic hypoxic-ischemic state caused by the events such as cord around neck.
Description
Technical field
The present invention relates to fetal brain blood oxygen detection device technical fields, and in particular to a kind of non-intrusion type foetus brain blood
Oxygen detection device and its method.
Background technique
Fetus is in utero having anoxic sign, and jeopardizes a kind of symptom complex of foetus health and life, referred to as fetal distress.
If pregnant woman has the diseases such as heart disease, diabetes, anemia, hypertension, ephritis, asthma, prolonged pregnancy in the gestational period, or
Because vascular lesion reduces uterine blood, perhaps because the function of placenta reduces or because of situations such as blood oxygen concentration is too low,
So that fetus is cannot get enough oxygen, causes growth retardation of fetus, polycythemia, movement of the foetus to reduce, even cause when serious
Foetal death.One of the main reason for this is current Cesarean esction.Fetal distress incidence is 2.7%~38.5%.It is main to occur
During just before giving birth, latter half of gestation may also occur at.
If long term hypoxia cannot correct, fetus brain edema can be caused, will lead to when with disease progression to Decompensated stage
Fetus " brain protection's effect " disappears, and life is on the hazard, and may finally lead to foetal death.The asphyxiated newborn infants of survival are also often because lacking
Oxygen leads to nervous system damage, causes the irreversible sequelae such as mental retardation, maimed person.Therefore detection human fetal brain blood oxygen is full
It is the very crucial indication whether clinical evaluation fetus needs Cesarean esction intervention with degree.
Antenatal detection Fetal Brain blood oxygen, early, takes control measure in time, has to reduction the perinatal fetal mortality important
Meaning.This needs to correctly detect means, precisely assesses fetal brain blood oxygen level, distinguish fetal distress in uterus it is true with it is false, it is suitable
Shi Shidu is intervened.Currently, fetal distress diagnosis index includes movement of the foetus, fetal heart monitoring, the observation of amniotic fluid character, ultrasonic following abdomen
Enclose measurement, target blood Doppler inspection etc..But the indirect due to detection means, lacks unified diagnostic criteria at limitation,
Cause antenatal exaination to be difficult to find placenta and umbilical cord abnormal caused by human fetal brain blood oxygen, and is difficult to identify in stages of labor
" real " fetal distress is sexually revised with fetus physiology.And the fetus blood gas analysis as diagnosis " gold standard ", it is to produce
A kind of invasive monitoring tool of Shi Caiyong.When fetal rhythm monitoring and ultrasonic examination prompt fetus may be abnormal, the tire of fetus when production
Youngster's blood oxygen saturation and blood gas analysis are critically important.But it is concurrent that invasive detection means can undoubtedly come wound, infection etc. to fetal zone
Disease, urgent clinical needs are noninvasive, convenient and fast fetal brain oxygen detection mode.
Summary of the invention
It is an object of the invention to develop a kind of non-intrusion type foetus brain blood oxygen detection device, substitution tradition is invasive
Scalp blood oxygen saturation, blood gas analysis means accomplish that whole process before, during and after the production process is carried out to foetus in real time, accurately supervises
Control.
The present invention adopts the following technical scheme:
On the one hand, the present invention provides a kind of non-intrusion type foetus brain blood oxygen detector device, the detecting instrument packets
Include probe and with it is described probe connection control device, it is described probe with her abdominal formed it is complete be bonded, set on the probe
There are light emitting source and multiple sensitivity specks, the light that the light emitting source is issued is walked respectively to her abdominal anterior tissue, fetus head
Corresponding emergent light is formed when shallow layer tissue and Fetal Brain tissue, multiple sensitivity specks separately detect corresponding outgoing
Light；Central processing module and the power module being electrically connected with the central processing module, light source are equipped in the control device
Drive module, sensitivity speck signal receiving module and data disaply moudle；The light source driver module and sensitivity speck signal receive
Module is connected by cable and the probe, and the light source driver module controls the light emitting source and shines, the sensitivity speck signal
Receiving module receives the photoreceptor signal of multiple sensitivity specks, obtains brain blood after the central processing module carries out data processing
Oxygen saturation value, and shown through the data disaply moudle.
The light source driver module controls the light emitting source and launches feux rouges and infrared light.
The wave band of the feux rouges and infrared light is 600nm~900nm.
The sensitivity speck includes the first sensitivity speck, the second sensitivity speck and third sensitivity speck, is shone according to apart from described
The distance in source is arranged in a linear on the probe, is respectively used to the outgoing that detection runs through her abdominal different tissues exit path
Feux rouges and infrared light.
The central processing module obtains the blood oxygenation information of each sensitivity speck according to Lambert-Beer's law, through returning
The cerebral blood oxygen saturation value of Fetal Brain tissue is calculated.
Brain oximetry value ScO2 regression formula used by the central processing module is:
ScO2=α1·St1O2+α2·St2O2+α3·St3O2+b
Wherein:
a1、a2And a3For regression coefficient, b is offset；
St1O2Reflect the blood oxygenation information of her abdominal anterior tissue；
St2O2Reflect the blood oxygenation information of her abdominal anterior tissue and fetus head shallow layer tissue；
St3O2Reflect the blood oxygenation information of her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissue.
The test surface of the probe is flexible probe in arc-shaped or the probe, for example is used with biocompatibility
Silica gel material.
It is additionally provided with the data export module connecting with the central processing module on the control device and mould is manually entered
Block.
On the other hand, the present invention also provides a kind of non-intrusion type foetus brain blood oxygen detection methods, and probe is bonded
In her abdominal；Light source driver module on control device for opening, the light emitting source controlled on probe shine, and make it to her abdominal
It is irradiated；Each sensitivity speck on probe is used to separately detect to walk her abdominal anterior tissue, fetus head shallow layer tissue
With the light of Fetal Brain tissue outgoing, and the sense of each sensitivity speck is received through the sensitivity speck signal receiving module on control device
Optical signal；The cerebral blood oxygen saturation value that fetus is obtained after central processing module handles photoreceptor signal, it is aobvious by data
Show that module is externally shown.
Control light emitting source alternate emission feux rouges and infrared light, the first sensitivity speck being arranged on probe, the second sensitivity speck and the
The specific path that three sensitivity specks separately detect the feux rouges and infrared light that are emitted by her abdominal tissue is:
The first sensitivity speck close to light emitting source detects the feux rouges and infrared light for walking her abdominal anterior tissue；
It is located in the middle the second sensitivity speck and detects and walk the red of her abdominal anterior tissue and fetus head shallow layer tissue
Light and infrared light；
Third sensitivity speck far from light emitting source, which detects, walks her abdominal anterior tissue, fetus head shallow layer tissue and tire
The feux rouges and infrared light of youngster brain tissue.
Technical solution of the present invention has the advantages that
A. the present invention is scanned her abdominal using probe, multiple sensitivity specks is arranged on probe, sensitivity speck is visited respectively
Her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissue and the emergent light reflected are walked in survey, then are passed through
Sensitivity speck signal receiving module receives the photoreceptor signal of each sensitivity speck respectively, and brain blood oxygen is obtained after central processing module is handled
Intensity value, and externally shown by data disaply moudle, the present invention is according to Lambert-Beer's law by obtained by pregnant woman
The light of abdomen outgoing obtains cerebral blood oxygen saturation value after carrying out recurrence calculating, does not need to carry out pregnant woman's body any injury, and
Noninvasive whole real time monitoring before, during and after the production process may be implemented, can be used during pregnancy period outpatient service and childbirth and the news commentary
Valence foetus brain oxygen situation, prevents encephalic hypoxic-ischemic state caused by the events such as cord around neck.
B. the present invention carries out her abdominal anterior tissue blood oxygen, fetus head shallow layer tissue using the combination of more spacing optical paths
Blood oxygen signal filters out, and greatly improves the accuracy to the detection of foetus brain blood oxygen, and simple, accuracy is high with detecting
Advantage.
C. the present invention has easy to operate, and can be operated by nurse operation use or family by pregnant woman kith and kin in outpatient service makes
With timely acquisition foetus brain oxygen situation；The pulse frequency situation of foetus can also be obtained simultaneously, it being capable of multi-parameter progress abdomen
The health evaluating of middle fetus.
Detailed description of the invention
It, below will be to needed in specific embodiment in order to illustrate more clearly of the specific embodiment of the invention
Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is some embodiments of the present invention, for this field
For those of ordinary skill, without creative efforts, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is the noninvasive brain blood oxygen detection schematic diagram of fetus provided by the present invention；
Fig. 2 is sonde configuration schematic diagram shown in Fig. 1；
Fig. 3 is probe acquisition fetus blood oxygenation information schematic diagram；
Fig. 4 is to show schematic cross-section in fetal brain blood oxygen detector device；
Fig. 5 is composed structure schematic diagram inside fetal brain blood oxygen detector device provided by the present invention.
It is identified in figure as follows:
1- probe；2- cable；3- detection device；4 illuminating sources；The first sensitivity speck of 5-；The second sensitivity speck of 6-；7- third sense
Luminous point；8- her abdominal anterior tissue；9- fetus head shallow layer tissue；10- human fetal brain；20- data disaply moudle.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
As shown in Figure 1 and Figure 5, the present invention provides a kind of non-intrusion type foetus brain blood oxygen detector devices, specific to wrap
Include probe and with probe connection control device, probe with her abdominal formed it is complete be bonded, probe be equipped with light emitting source with it is more
A sensitivity speck, the light that light emitting source is issued are walked to her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain group
Corresponding emergent light is formed when knitting, multiple sensitivity specks separately detect corresponding emergent light；Centre is equipped in control device
Manage module and the power module being electrically connected with central processing module, light source driver module, sensitivity speck signal receiving module sum number
According to display module；Light source driver module and sensitivity speck signal receiving module are connected by cable and probe, light source driver module control
Light emitting source processed shines, and sensitivity speck signal receiving module receives the photoreceptor signal of multiple sensitivity specks, is counted through central processing module
According to acquisition cerebral blood oxygen saturation value after processing, and shown through data disaply moudle.Light source driver module of the present invention is excellent
Selected control light emitting source launches the feux rouges and infrared light that multichannel wave band is 600nm-900nm.
As shown in Figures 2 and 3, the sensitivity speck on probe therein includes the first sensitivity speck, the second sensitivity speck and third sense
Luminous point is arranged in a linear on probe according to the distance apart from light emitting source, is respectively used to detection through her abdominal difference group
Knit the outgoing feux rouges and infrared light of exit path, that is to say, that detect close to the first sensitivity speck of light emitting source and walk pregnant woman's abdomen
The feux rouges and infrared light of portion's anterior tissue are located in the middle the second sensitivity speck and detect and walks her abdominal anterior tissue and fetus
The feux rouges and infrared light of head shallow layer tissue；Far from light emitting source third sensitivity speck detect walk her abdominal anterior tissue,
The feux rouges and infrared light of fetus head shallow layer tissue and Fetal Brain tissue.
For the feux rouges and infrared light point of the different tissues that the first sensitivity speck, the second sensitivity speck, third sensitivity speck are detected
It is not received by sensitivity speck signal receiving module, central processing module obtains each sensitivity speck according to Lambert-Beer's law
Blood oxygenation information, the cerebral blood oxygen saturation value of Fetal Brain tissue is calculated through returning.The present invention uses more spacing optical path groups
Close and carry out her abdominal anterior tissue blood oxygen, the blood oxygen signal of fetus head shallow layer tissue filters out, greatly improve to tire in abdomen
The accuracy of youngster's brain blood oxygen detection, and have the advantages that detection is simple, accuracy is high.
Brain oximetry value S used by central processing module in the present inventioncO2Regression formula is: ScO2=α1·
St1O2+α2·St2O2+α3·St302+b
Wherein: St1O2Reflect the blood oxygenation information of her abdominal anterior tissue；
St2O2Reflect the blood oxygenation information of her abdominal anterior tissue and fetus head shallow layer tissue；
St3O2Reflect the blood oxygenation information of her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissue.
It is detected by the series to pregnant woman's foetus brain oximetry data, regression coefficient is calculated using least square method
a1、a2And a3With the numerical value of offset b, the S that then will newly obtaint1O2、St2O2And St3O2Data input above-mentioned regression formula
Afterwards, corresponding brain oximetry value ScO can be obtained2。
In order to preferably make probe adapt to the abdomen shape of different pregnant woman, the present invention is preferably visited probe using flexible
Head, such as using the silica gel material or other flexible materials with biocompatibility.It can certainly be by the detection wheat flour of probe
At the shape with fixed radian, it is easy to implement the accurate reception of light.
In addition, being additionally provided with the data export module connecting with the central processing module on control device and mould being manually entered
Block can input Patient ID information by manual input module, carry out the operation such as system setting, can also be by pregnant woman detected
And the data of fetus are exported by data export module.Blood oxygenation information by detecting Fetal Brain tissue obtained can be with
It is shown by cerebral blood oxygen saturation curve form shown in Fig. 4, can more intuitively observe cerebral blood oxygen saturation value
Variation tendency.
Specific operation process is as shown in Figure 1:
(1) probe is reached by cable transmission multichannel feux rouges and infrared light by the light emitting source drive module of detecting instrument (to visit
Head surface is as shown in Figure 2), probe is bonded with her abdominal, since feux rouges and infrared light have good diffusivity, can be penetrated pregnant
Woman's anterior abdominal wall tissue enters in utero.When fetus head and uterine wall attach, feux rouges can be diffused into further with infrared light
Fetus head can be reflected and be diffused out again from adjacent tissue after continuing to walk into human fetal brain.
(2) influence when feux rouges and infrared light are walked within the organization by tissue resorption, reflection or diffusion can pass through
The arc path of Banana Type is pierced by.Three paths that photon is walked are representatively illustrated in Fig. 3.
(3) the first sensitivity speck, the second sensitivity speck and third after feux rouges and infrared light are pierced by her abdominal, on probe
Sensitivity speck can detect the feux rouges and infrared light of outgoing.According to Lambert-Beer's law (Beer-Lambert Law), detect
Emergent light and the ratio of light intensity of incident light can be connected with the concentration of oxygen-containing hemoglobin, deoxyhemoglobin.Into
And the percentage of the oxygen-containing hemoglobin in available respective organization.
(4) the traveling path of the corresponding feux rouges and infrared light detected due to each sensitivity speck is different, and different
The tissue that path emergent light passes through is visibly different.It is reference with light emitting source, what the first sensitivity speck of proximal end mainly reflected is
The blood oxygenation information S of her abdominal anterior tissuet1O2, what the second intermediate sensitivity speck then mainly reflected is her abdominal antetheca and tire
The blood oxygenation information S of youngster head shallow layer tissue (such as scalp, skull, cerebrospinal fluid)t2O2, what the third sensitivity speck of distal end then reflected is
The blood oxygenation information S of her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissuet3O2。
(5) pass through following regression formula, the brain blood oxygenation information of our available fetuses:
ScO2=α1·St1O2+α2·St2O2+α3·St3O2+b
(6) recurrence of fetal brain blood oxygen is calculated is completed by the central processing module in fetal brain blood oxygen detector device.Data
Curve can be carried out by data disaply moudle after the completion of calculating to show, while can also show real-time cerebral blood oxygen saturation number
Value.Interface is as shown in Figure 4.
The present invention is truly realized the real time monitoring in antenatal and production to fetus, uses during pregnancy period outpatient service and childbirth,
Evaluation foetus brain oxygen situation in time, prevents encephalic hypoxic-ischemic state caused by the events such as cord around neck.It is also convenient for simultaneously
Operation, can be used in outpatient service by nurse operation or family is operated with by pregnant woman kith and kin, obtain foetus brain oxygen in time
Situation；The pulse frequency situation of foetus can also be obtained, is capable of the health evaluating of multi-parameter progress foetus, makes assessment result
It is more acurrate.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
Variation is still in the protection scope of this invention.
Claims (10)
1. a kind of non-intrusion type foetus brain blood oxygen detector device, which is characterized in that the detecting instrument include probe and with
It is described probe connection control device, it is described probe with her abdominal formed it is complete be bonded, the probe be equipped with light emitting source with
Multiple sensitivity specks, the light that the light emitting source is issued walk respectively to her abdominal anterior tissue, fetus head shallow layer tissue and
Corresponding emergent light is formed when Fetal Brain tissue, multiple sensitivity specks separately detect corresponding emergent light；The control
In device processed be equipped with central processing module and with the central processing module be electrically connected power module, light source driver module,
Sensitivity speck signal receiving module and data disaply moudle；The light source driver module and sensitivity speck signal receiving module passes through line
Cable and the probe connect, and the light source driver module controls the light emitting source and shines, and the sensitivity speck signal receiving module connects
The photoreceptor signal for receiving multiple sensitivity specks obtains cerebral blood oxygen saturation after the central processing module carries out data processing
Value, and shown through the data disaply moudle.
2. non-intrusion type foetus brain blood oxygen detector device according to claim 1, which is characterized in that the light source drives
Dynamic model block controls the light emitting source and launches feux rouges and infrared light.
3. non-intrusion type foetus brain blood oxygen detector device according to claim 2, which is characterized in that the feux rouges and
The wave band of infrared light is 600nm~900nm.
4. non-intrusion type foetus brain blood oxygen detector device according to claim 3, which is characterized in that described is photosensitive
Point includes the first sensitivity speck, the second sensitivity speck and third sensitivity speck, according to the distance apart from the light emitting source in the probe
On be arranged in a linear, be respectively used to detection run through her abdominal different tissues exit path outgoing feux rouges and infrared light.
5. non-intrusion type foetus brain blood oxygen detector device according to claim 4, which is characterized in that the centre
It manages module and the blood oxygenation information of each sensitivity speck is obtained according to Lambert-Beer's law, Fetal Brain group is calculated through returning
The cerebral blood oxygen saturation value knitted.
6. non-intrusion type foetus brain blood oxygen detector device according to claim 5, which is characterized in that the centre
Manage brain oximetry value S used by modulecO2Regression formula is:
ScO2=α1·St1O2+α2·St2O2+α3·St3O2+b
Wherein: a1、a2And a3For regression coefficient, b is offset；
St1O2Reflect the blood oxygenation information of her abdominal anterior tissue；
St2O2Reflect the blood oxygenation information of her abdominal anterior tissue and fetus head shallow layer tissue；
St3O2Reflect the blood oxygenation information of her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain tissue.
7. non-intrusion type foetus brain blood oxygen detector device according to claim 1, which is characterized in that the probe
Test surface is flexible probe in arc-shaped or the probe.
8. non-intrusion type foetus brain blood oxygen detector device according to claim 1, which is characterized in that the control dress
Set the data export module and manual input module for being additionally provided with and being electrically connected with the central processing module.
9. a kind of non-intrusion type foetus brain blood oxygen detection method, which is characterized in that probe is fitted in her abdominal；It opens
Light source driver module on control device, the light emitting source controlled on probe shine, and are irradiated it to her abdominal；On probe
Each sensitivity speck be respectively intended to detection and walk her abdominal anterior tissue, fetus head shallow layer tissue and Fetal Brain group and weave
The light penetrated, and receive through the sensitivity speck signal receiving module on control device the photoreceptor signal of each sensitivity speck；Through centre
Reason module obtains the cerebral blood oxygen saturation value of fetus after handling photoreceptor signal, is externally shown by data disaply moudle.
10. non-intrusion type foetus brain blood oxygen detection method according to claim 9, which is characterized in that control shines
Source emits feux rouges and infrared light, and the first sensitivity speck, the second sensitivity speck and the third sensitivity speck being arranged on probe are separately detected by pregnant
The feux rouges of woman's abdominal tissues outgoing and the specific path of infrared light are:
The first sensitivity speck close to light emitting source detects the feux rouges and infrared light for walking her abdominal anterior tissue；
Be located in the middle the second sensitivity speck detect walk her abdominal anterior tissue and fetus head shallow layer tissue feux rouges and
Infrared light；
Third sensitivity speck far from light emitting source, which detects, walks her abdominal anterior tissue, fetus head shallow layer tissue and fetal brain
The feux rouges and infrared light of portion's tissue.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111466917A (en) * | 2020-04-13 | 2020-07-31 | 湖北七纵八横网络科技有限公司 | Multi-point type fetal movement monitoring method and device |
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