CN109463762A - Application and soft capsule and preparation method thereof of the DHA grease composition in soft capsule - Google Patents
Application and soft capsule and preparation method thereof of the DHA grease composition in soft capsule Download PDFInfo
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- CN109463762A CN109463762A CN201811506742.6A CN201811506742A CN109463762A CN 109463762 A CN109463762 A CN 109463762A CN 201811506742 A CN201811506742 A CN 201811506742A CN 109463762 A CN109463762 A CN 109463762A
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- dha
- soft capsule
- oil
- dha grease
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- 239000004519 grease Substances 0.000 title claims abstract description 117
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000002253 acid Substances 0.000 claims abstract description 15
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 claims abstract description 15
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
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- 238000000034 method Methods 0.000 claims description 47
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- 235000019198 oils Nutrition 0.000 claims description 40
- 238000001035 drying Methods 0.000 claims description 26
- 239000002775 capsule Substances 0.000 claims description 24
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 22
- 239000003963 antioxidant agent Substances 0.000 claims description 18
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- 238000003860 storage Methods 0.000 claims description 17
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 5
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 210000002569 neuron Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 208000006155 precocious puberty Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to food processing technology fields, and in particular to application and a kind of soft capsule and preparation method thereof of the DHA grease composition in soft capsule.DHA grease composition contains DHA grease, and DHA grease contains DHA and EPA；The applicable object of soft capsule is pregnant and lying-in women, infant and teenager, and the content ratio of DHA and EPA are greater than 12:1；The applicable object of soft capsule is person in middle and old age, and the content ratio of DHA and EPA are not more than 8:1.Preparation method includes: that water, jelly powder and glycerol are mixed to and carried out colloidal sol, obtains collosol intermixture；DHA grease composition as above is poured into collosol intermixture, soft capsule is obtained；The present invention, which can be prepared, meets different crowd DHA soft capsule.Preferably, additionally it is possible to effectively slow down the oxidation of grease, reduce anisidine value, peroxide number and acid value, control the discoloration of soft capsule, increase the holding time of DHA grease soft capsule.
Description
Technical field
The present invention relates to food processing technology fields, and in particular to DHA grease composition in soft capsule application and
A kind of soft capsule and preparation method thereof.
Background technique
Docosahexaenoic acid (DHA) is a kind of long-chain polyunsaturated fatty acid, is primarily present in grey matter portion in the brain
Point, it is the fatty acid composition that main lipid components and brain cell preferential absorption utilize in Human Fetal Brain Neuron.DHA exists
Content in optic nerve cell and retinal tissue is up to 40-47%, plays an important role to the normal function of visual sense light receptor,
If lacking DHA in food, DHA content in retinal tissue can be made to decline, declined so as to cause eyesight and resolving power.DHA is also
Thrombosis can be reduced, plays the role of preventing cardiovascular disease.Meanwhile DHA is delaying senescence, is preventing nerve disease
Disease (such as prevention senile dementia slows down the anxiety disorder state of an illness), inhibits tumour at anticancer, and pre- preventing bone rarefaction, resists prevention diabetes
Inflammation etc. also has apparent effect.
The World Health Organization (WHO) and United States Medicine research institute (IOM) are unanimously recommended, and pregnancy and breast feeding women are daily
DHA intake is 200mg, and the daily minimum intake of Healthy People should be 160mg, and -18 years old 4 years old youngsters and childrens are daily ingestion of
Amount is 90-160mg.And the daily intake of the current pregnant woman in China, breast feeding women, children and adults is far below the level.
EPA can inhibit the synthesis of liver fat and lipoprotein, promote cholesterol excretion, reduce the triglyceride in blood
And low density cholesterol, while increasing beneficial high density cholesterol.It effectively prevent the generation of hyperlipidemia.And it is small to can inhibit blood
Plate cohesion, reduces the formation of thrombus.Blood vessel is expanded simultaneously, reduces blood viscosity, increases red blood cell plasticity, improves blood platelet
The unimpeded of blood vessel is safeguarded in membrane fluidity, help.The occurrence probability for reducing atherosclerosis, to reduce the hair of cardiovascular and cerebrovascular diseases
Sick rate.
But inventor has found in the course of the study, this " blood vessel scavenger " effect of EPA, and infant is come
It says, then can generate negative impact: and by a large amount of studies have shown that EPA has the work for reducing blood viscosity, dilute blood
With pregnant woman and the interior accumulation of infants easily cause improper bleeding, in addition, EPA will be metabolized to prostate in human body
Ring element PG3 and have promote children's sexual precocity disadvantage.
And the ratio of DHA and EPA is not adjusted in the soft capsule comprising DHA and EPA according to different crowds currently on the market
Example, is unfavorable for human body to the supplement of DHA and EPA and the health of human body.
Summary of the invention
The purpose of the invention is to overcome the above problem of the existing technology, a kind of specific DHA grease group is provided
Close application and a kind of soft capsule and preparation method thereof of the object in soft capsule.
To achieve the goals above, first aspect present invention provides following DHA grease composition answering in soft capsule
With the DHA grease composition contains DHA grease, and the DHA grease contains DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA with
The content ratio of EPA is greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content of DHA and EPA are than little
In 8:1.
Preferably, the DHA grease composition also contains antioxidant.
Preferably, the DHA grease composition also contains walnut oil, perilla herb oil, sunflower oil, evening primrose oil, grape pip
At least one of oil, soybean oil, linseed oil, rapeseed oil and olive oil.
Second aspect of the present invention provides a kind of preparation method of soft capsule, this method comprises:
(1) water, jelly powder and glycerol are mixed to and carried out colloidal sol, obtains collosol intermixture；
(2) DHA grease composition is poured into the collosol intermixture, obtains soft capsule；
Wherein, the DHA grease composition contains DHA grease, and the DHA grease contains DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA with
The content ratio of EPA is greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content of DHA and EPA are than little
In 8:1.
Preferably, the DHA grease composition also contains walnut oil, perilla herb oil, sunflower oil, evening primrose oil, grape pip
At least one of oil, soybean oil, linseed oil, rapeseed oil and olive oil.
Preferably, the DHA grease composition also contains antioxidant, it is preferred that the DHA grease composition pass through by
DHA grease and antioxidant are mixed to get, the mixed environment temperature lower than 25 DEG C, relative humidity less than 65%, feed liquid temperature
Degree is lower than 30 DEG C.Preferably, this method further includes that the DHA grease composition that will be prepared carries out Fruit storage.It is preferred that
, the storage time of the DHA grease composition is not more than 2 hours, and is protected from light storage in an inert atmosphere.
Preferably, it is 60-85 DEG C that the condition of the colloidal sol, which includes: temperature, and steam pressure is less than 0.2MPa, time 40-
50min.Preferably, after colloidal sol, obtained collosol intermixture is filtered and vacuum outgas under conditions of 45-75 DEG C
Processing, and the collosol intermixture after filtering and Fruit storage is kept the temperature.Preferably, the storage of the collosol intermixture
Time is not more than 48 hours.
Preferably, the gelatin is pharmagel.
Preferably, the power value of the gelatin is 180-200Bloom g.
Preferably, it is 18-28 DEG C that the condition of the perfusion, which includes: pelleting environment temperature, and relative humidity is not more than 80%, glue
Skin cooling and shaping temperature≤25 DEG C.
Preferably, this method further includes that the soft capsule that will be obtained is dried, the drying include successively carry out it is primary
Dry and redrying；The condition of the primary drying includes: humidity no more than 80%, and temperature is 26-32 DEG C, time 4-8
Hour；The condition of the redrying includes: humidity no more than 45%, and temperature is 30-45 DEG C, relative humidity≤30%, the time
It is 4-8 hours.Wherein, the humidity of primary drying is greater than the humidity of redrying, and the temperature of primary drying is lower than redrying
Temperature.
Preferably, this method includes carrying out the soft capsule after drying clearly to obtained soft capsule using food-grade petroleum ether
It washes, to remove the Residual oil of capsule surface, alternatively, this method includes using oil suction cloth by the soft capsule after drying to obtained glue
Capsule is washed by rubbing with the hands, and substitution petroleum ether is cleaned to remove the Residual oil of capsule surface.
The third aspect, the present invention provides the soft capsules of method as described above preparation, wherein the soft capsule is applied to
Infant, the teenager consumer groups different with person in middle and old age, peroxide value≤15meq/kg, acid value≤3mg/ in the soft capsule
G, anisidine value≤15.
Through the above technical solutions, the soft capsule for the composition containing DHA grease for meeting different crowds can be prepared, meet
Requirement of the different crowd to DHA and EPA maintains the function of infant and teenager's brain, promotes its brain and vision system
Development prevents the side effects such as abnormal bleeding and sex premature, while the blood lipid of adjustable person in middle and old age, reduces blood stagnation
Degree prevents senile dementia.In the case where furthermore it is preferred that, DHA in grease can effectively be slowed down using above-mentioned anti-oxidation method
With the oxidation of EPA, anisidine value, peroxide number and the acid value of DHA grease composition are reduced, the discoloration of soft capsule is controlled, increased
Add the holding time of DHA grease soft capsule.
Detailed description of the invention
Fig. 1 is a kind of flow chart of specific embodiment of the present invention.
Specific embodiment
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The present inventor has found in the course of the study, for pregnant and lying-in women, infant and teenager, in supply DHA
When grease, the content ratio of the DHA and EPA in DHA grease are greater than 12:1, further preferably greater than 20:1, still more preferably
Greater than 30:1, the side effect that EPA generates pregnant and lying-in women, infant and teenager can avoid, and for person in middle and old age, it can properly increase
The content of EPA in DHA grease, content ratio is not more than 8:1, preferably no greater than 3:2, thus the generation of prevention of arterial atherosis
Probability, to reduce the disease incidence of cardiovascular and cerebrovascular diseases.
Based on discovery as above, in a first aspect, the present invention provides following DHA grease composition answering in soft capsule
With the DHA grease composition contains DHA grease, and the DHA grease contains DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA with
The content ratio of EPA is greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content of DHA and EPA are than little
In 8:1.
(1) applicable object of the soft capsule is pregnant and lying-in women, infant and teenager
Preferably, in the DHA grease composition, the content ratio of DHA and EPA are greater than 12:1, preferably greater than 20:1, more excellent
It is selected as being greater than 30:1.
Wherein, the source of the DHA grease can be selected in a wider scope, it is preferred that DHA grease is algae
The DHA grease in source, in the alga-derived DHA grease content of DHA preferably >=content of 35 weight %, EPA preferably≤3
Weight %.Wherein, the alga-derived DHA grease can be commercially available by conventional approach, can also be according to existing work
Skill is prepared.
Wherein, the example of the algae may include but be not limited to thraustochytriale (Thraustochytriales), split
Grow chytrid (Schizochytrium), hidden dinoflagellate (Crypthecodinium), diatom (diatom), spirulina (Spirulina)
At least one of Bordetella is agreed with me.
(2) applicable object of the soft capsule is person in middle and old age
Preferably, the DHA grease contains fish oil or the mixture containing fish oil and algae oil, it is furthermore preferred that the fish
DHA content >=12 weight % in oil.The content of EPA preferably >=18 weight %.Wherein, the fish oil can pass through conventional approach
It is commercially available, it can also be prepared according to prior art.
The present inventor has found in the course of the study, this long-chain polyunsaturated fatty acid of DHA, because containing double bond
Cause oxidation stability bad, easily oxidation leads to poor quality, the technique that existing soft capsule production technology uses common grease
Production, does not take the safeguard measure for preventing Oxidation of Fat and Oils, easily leads to final finished product soft gel products oxidation deterioration.And this
The aggregate measures that the method for invention is controlled using following oxidation protection: be properly added food-grade oil antioxidant, isolating oxygen,
Shortening grease exposure duration etc. effectively prevents the oxidation deterioration of soft capsule.
According to the present invention, the further oxidation in DHA grease composition in order to prevent, the DHA grease composition are also excellent
Choosing contains antioxidant, wherein the antioxidant can be existing conventional various edible antioxidants.According to this hair
A kind of bright preferred embodiment, the antioxidant in vitamin E, lecithin, VC palmitate and rosemary extremely
Few one kind, content is preferably 800-1500ppm, for example, can for 800ppm, 900ppm, 1000ppm, 1100ppm,
1200ppm、1300ppm、1400ppm、1500ppm。
A kind of preferred embodiment according to the present invention also contains edible fats in the DHA grease composition, described
Edible fats are preferably selected from walnut oil, perilla herb oil, sunflower oil, evening primrose oil, grape seed oil, soybean oil, linseed oil, dish
At least one of seed oil and olive oil.In the preferred situation, the inoxidizability of the soft capsule can be further enhanced, from
And the discoloration of soft capsule can be further suppressed, to reduce anisidine value, peroxide value and acid value.
According to the present invention, jelly powder and glycerol can be usually contained in the capsule skin of the soft capsule.
According to the second aspect of the invention, the present invention provides a kind of preparation methods of soft capsule, this method comprises:
(1) water, jelly powder and glycerol are mixed to and carried out colloidal sol, obtains collosol intermixture；
(2) DHA grease composition is poured into the collosol intermixture, obtains soft capsule；
Wherein, the DHA grease composition contains DHA grease, and the DHA grease contains DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA with
The content ratio of EPA is greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content of DHA and EPA are than little
In 8:1.
According to the present invention, the selection of the grease of different applicable objects has carried out detailed Jie in first aspect as above
It continues, it is no longer repeated herein.
A kind of preferred embodiment according to the present invention also contains edible fats in the DHA grease composition, described
Edible fats are preferably selected from walnut oil, perilla herb oil, sunflower oil, evening primrose oil, grape seed oil, soybean oil, linseed oil, dish
At least one of seed oil and olive oil.In the preferred situation, the inoxidizability of the soft capsule can be further enhanced, from
And the discoloration of soft capsule can be further suppressed, to reduce anisidine value, peroxide value and acid value.
According to the present invention, in order to further increase the inoxidizability in preparation process, the discoloration of the soft capsule inhibited,
To reduce anisidine value, peroxide value and acid value, it is preferred that the DHA grease composition also contains antioxidant, wherein
The selection of the antioxidant and dosage are in detailed introduction executed as described above, and it is no longer repeated herein.
According to the present invention, the preparation of DHA grease composition can by by each material carry out it is conventional being mixed to get, in order to
The oxidation reaction in soft capsule preparation process is further suppressed, the discoloration of soft capsule is inhibited, to reduce anisidine value, peroxidating
Value and acid value, it is preferred that the environment for mixing the substances such as the DHA grease and antioxidant, edible fats as above
Temperature is preferably shorter than 25 DEG C, preferably 10-25 DEG C, and for relative humidity less than 65%, the temperature of feed liquid is lower than 30 DEG C.Wherein, described mixed
Conjunction can carry out 70-80min under stirring conditions.It is further preferred that further including the DHA grease composition that will be prepared
Fruit storage is carried out, to avoid the excessive contact of DHA grease and oxygen.Still more preferably, the DHA being mixed to get
The storage time of fat or oil composition is not more than 2 hours, preferably no greater than 1.5 hours, more preferably matching while using, so as to shorten object
Expect aerial exposure duration, and store process and preferably carried out under the protection of inert gas, the inert gas can be with
For nitrogen.
According to the present invention, in step (1), in order to further decrease the oxidation in capsule preparation process, to inhibit capsule
Discoloration, reduce anisidine value, peroxide value and acid value, it is preferred that the temperature of the colloidal sol is 60-85 DEG C, more preferably 70-
77 DEG C, for example, 70 DEG C, 71 DEG C, 72 DEG C, 73 DEG C, 74 DEG C, 75 DEG C, 76 DEG C, 77 DEG C, steam pressure be less than 0.2MPa (for example,
0.1-0.2MPa), time 40-50min.
In the present invention, the water, jelly powder and glycerol dosage can according to dosage when preparing soft capsule in prior art,
Preferably, the water relative to 100 parts by weight, the dosage of jelly powder is 80-120 parts by weight, the dosage of glycerol is 35-50 weight
Part.Further preferred, the ingredients by weight ratio of glycerol and gelatin is (35-50): 100, it specifically can be according to locating for market
The consumption proportion of temperature and damp condition adjustment glycerol and gelatin, the hardness of commodity capsule is ensured with this.
According to the present invention, in step (1), in order to further decrease the oxidation in capsule preparation process, to inhibit capsule
Discoloration, reduce anisidine value, peroxide value and acid value, it is preferred that further include mixing obtained colloidal sol after colloidal sol
Object is filtered and Fruit storage at 45-75 DEG C at a temperature of preferably 58-62 DEG C, and will filtering and Fruit storage
Collosol intermixture afterwards keep the temperature spare.
According to the present invention, in step (1), for the collosol intermixture reduced aerial exposure duration, thus
Degree of oxidation is reduced, the discoloration of capsule is inhibited, reduces anisidine value, peroxide value and acid value, it is preferred that the collosol intermixture
Storage time be not more than 48 hours, preferably no greater than 40 hours, more preferably no more than 30 hours are further preferably current existing
Match.
According to the present invention, in order to further decrease the foreign ion in gelatin, for example, influence of the metal ion to discoloration,
Preferably, the gelatin is pharmagel.Wherein, the power value of the gelatin can select in a wider scope, but this
Application inventors have found that controlling the power value of gelatin in 180-200Bloom g (for example, 180Bloom g, 185Bloom
g、190Bloom g、195Bloom g、200Bloom g、205Bloom g、210Bloom g、215Bloom g、220Bloom
G) discoloration of soft capsule can be further suppressed.
According to the present invention, in step (2), DHA grease composition is poured into the method in the collosol intermixture can be with
Using the method for preparing soft capsule in the prior art, the present invention is not particularly limited this.
Preferably, for the collosol intermixture reduced aerial exposure duration, to reduce degree of oxidation, press down
The discoloration of glue capsule, the condition of the perfusion include: pelleting environment temperature be 18-28 DEG C, preferably 18-24 DEG C, relative humidity
No more than 80%, preferably no greater than 65%, for example, 50-65%, rubber cooling and shaping temperature≤25 DEG C, preferably≤14 DEG C, example
Such as, 2-14 DEG C.
A kind of preferred embodiment according to the present invention, this method further includes that the product after perfusion is dried, described
Drying can be carried out according to the method for this field routine, however the present inventor has found in the course of the study, will be described
The soft or hard journey of further adjustment and control finished product is capable of in the dry drying for being divided into two stages of primary drying and redrying
Degree, control slow down the cracking problem with control finished capsule product.Wherein, the condition of the primary drying includes: that humidity is not more than
80%, preferably no greater than 65% (preferably 60-65%), temperature are 26-32 DEG C, and the time is 4-8 hours；The item of the redrying
Part includes: humidity no more than 45%, and preferably no greater than 30% (preferably 25-30%), temperature is 30-45 DEG C, and relative humidity≤
30%, the time is 4-8 hours.Wherein, the temperature of primary drying is lower than the temperature of redrying, 2-8 DEG C preferably low.
A kind of preferred embodiment according to the present invention avoids and slows down into further suppress the discoloration of finished product
Oxidation of the product capsule in the shelf-life further includes soft to what is obtained using food-grade petroleum ether after the soft capsule is dry
Capsule is cleaned, to remove the Residual oil of capsule surface.Since petroleum ether is easy to volatilize, after cleaning, petroleum ether
The surface of soft capsule will not be remained in sheet.
Another preferred embodiment according to the present invention, in order to further suppress the discoloration of finished product, avoiding and slow down
Oxidation of the finished capsule product in the shelf-life can also be by using oil suction cloth to obtaining after the soft capsule is dry
Capsule is washed by rubbing with the hands, and substitution petroleum ether is cleaned to remove the Residual oil of capsule surface.Wherein, the oil suction cloth is strong oil absorbing cloth
Item.
Wherein, in order to further prevent the oxidation of DHA grease in soft capsule, this method further include: the soft capsule that will be obtained
It is stored in lighttight bottle, oxygen absorbent is housed, and bottleneck is sealed using aluminium-foil paper in the bottle；Or the flexible glue that will be obtained
Capsule is sub-packed in aluminium-plastic panel.
The third aspect, the present invention also provides the soft capsules that method as described above is prepared, wherein the soft capsule
The consumer groups different with person in middle and old age applied to infant, teenager, peroxide value≤15meq/kg, acid value in the soft capsule
≤ 3mg/g, anisidine value≤15.
The present invention will be described in detail by way of examples below.In following embodiment,
In following embodiment and comparative example,
Microbial oil used is algae oil, and DHA content is 45.3 weight %, and EPA content is 0.613 weight %.
In fish oil used, DHA content is 12.16 weight %, and EPA content is 18.69 weight %.
Soft capsule Preparation equipment is the pellet processing machine of II RJNJ-2 of model MARK.
Embodiment 1
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
(1) colloidal sol
Colloidal sol pot carries out 15-30 minutes wet sterilizations, including input and output material nozzle before manufacture.Then needed for being prepared by glue
Water (100 parts by weight) be heated in boiling sucking colloidal sol pot, and stirring is opened, under stirring conditions, by glycerol (45 weight
Part) and pharmagel powder (power value be 190Bloom g) (100 parts by weight) successively sucking colloidal sol pot, stirring and dissolving, and 75
DEG C, colloidal sol 45min under conditions of steam pressure 0.2MPa.After colloidal sol, when temperature is reduced to about 60 DEG C, colloidal sol is mixed
Object is successively filtered and vacuum outgas, then carry out keeping the temperature it is spare, the holding time be no more than 48 hours.
(2) preparation of DHA grease composition
It is lower than 25 DEG C in environment temperature, under conditions of relative humidity is less than 65%, algae oil is added in proportion container, together
When vitamin E be added in sunflower oil that is appropriate and being heated to 85 DEG C dissolve, after feed liquid temperature decreases below 30 DEG C
It is poured into measurer, stirring 75min obtains DHA grease composition, wherein the content of vitamin E is 1200ppm.Then
The progress vacuum outgas of obtained DHA grease composition is spare, and the holding time is no more than 2 hours.
(3) prepared by soft capsule
The DHA grease composition in step (2) is poured into the colloidal sol of step (1) in pellet processing machine and carries out pelleting.Its
In, pelleting environment temperature is 20 DEG C, relative humidity 65%, 10 DEG C of rubber cooling and shaping temperature.The rubber of obtained soft capsule
With a thickness of 0.65-0.8mm, the average weight of single soft capsule is 430mg.
Obtained soft capsule is dried into 6h under conditions of humidity is 65%, temperature is 30 DEG C；Then it is in humidity again
30%, drying 6h under conditions of temperature is 32 DEG C.The soft capsule after drying is cleaned using food grade petroleum ether later, is obtained
To soft capsule, specific preparation flow is as shown in Figure 1.
Embodiment 2
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
(1) colloidal sol
Colloidal sol pot carries out 15-30 minutes wet sterilizations, including input and output material nozzle before manufacture.Then needed for being prepared by glue
Water (100 parts by weight) be heated in boiling sucking colloidal sol pot, and stirring is opened, under stirring conditions, by glycerol (42 weight
Part) and pharmagel powder (power value be 180Bloom g) (120 parts by weight) successively sucking colloidal sol pot, stirring and dissolving, and 70
DEG C, colloidal sol 40min under conditions of steam pressure 0.1MPa.After colloidal sol, when temperature is reduced to about 58 DEG C, colloidal sol is mixed
Object is successively filtered and vacuum outgas, then carry out keeping the temperature it is spare, the holding time be no more than 48 hours.
(2) preparation of DHA grease composition
It is lower than 25 DEG C, under conditions of relative humidity is less than 65% in environment temperature, the temperature control of feed liquid is being lower than 30
DEG C, algae oil and lecithin are added in proportion container, stirring 75min obtains DHA grease composition, wherein lecithin contains
Amount is 800ppm.Then the progress vacuum outgas of obtained DHA grease composition is spare, the holding time is no more than 2 hours.
(3) prepared by soft capsule
The DHA grease composition in step (2) is poured into the colloidal sol of step (1) in pellet processing machine and carries out pelleting.Its
In, pelleting environment temperature is 18 DEG C, relative humidity 60%, 14 DEG C of rubber cooling and shaping temperature.The rubber of obtained soft capsule
With a thickness of 0.65-0.8mm, the average weight of single soft capsule is 430mg.
Obtained soft capsule is dried into 8h under conditions of humidity is 60%, temperature is 26 DEG C；Then it is in humidity again
25%, drying 8h under conditions of temperature is 30 DEG C.The soft capsule after drying is cleaned using food grade petroleum ether later, is obtained
To soft capsule, specific preparation flow is as shown in Figure 1.
Embodiment 3
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
(1) colloidal sol
Colloidal sol pot carries out 15-30 minutes wet sterilizations, including input and output material nozzle before manufacture.Then needed for being prepared by glue
Water (100 parts by weight) be heated in boiling sucking colloidal sol pot, and stirring is opened, under stirring conditions, by glycerol (40 weight
Part) and pharmagel powder (power value be 200Bloom g) (80 parts by weight) successively sucking colloidal sol pot, stirring and dissolving, and 77
DEG C, colloidal sol 50min under conditions of steam pressure 0.15MPa.After colloidal sol, when temperature is reduced to about 62 DEG C, colloidal sol is mixed
It closes object to be successively filtered and vacuum outgas, then carries out keeping the temperature spare, the holding time is no more than 48 hours.
(2) preparation of DHA grease composition
It is lower than 25 DEG C in environment temperature, under conditions of relative humidity is less than 65%, fish oil is added in proportion container, together
When VC palmitate be added in sunflower oil that is appropriate and being heated to 85 DEG C dissolve, decrease below 30 DEG C to feed liquid temperature
After be poured into measurer, stirring 75min obtain DHA grease composition, wherein the content of VC palmitate be 1500ppm.So
Afterwards that the progress vacuum outgas of obtained DHA grease composition is spare, the holding time is no more than 2 hours.
(3) prepared by soft capsule
The DHA grease composition in step (2) is poured into the colloidal sol of step (1) in pellet processing machine and carries out pelleting.Its
In, pelleting environment temperature is 24 DEG C, relative humidity 63%, 8 DEG C of rubber cooling and shaping temperature.The rubber of obtained soft capsule
With a thickness of 0.65-0.8mm, the average weight of single soft capsule is 430mg.
Obtained soft capsule is dried into 4h under conditions of humidity is 63%, temperature is 32 DEG C；Then it is in humidity again
28%, drying 4h under conditions of temperature is 40 DEG C.The soft capsule after drying is cleaned using food grade petroleum ether later, is obtained
To soft capsule, specific preparation flow is as shown in Figure 1.
Embodiment 4
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (2), it is added without vitamin E,
That is, the DHA grease composition is only algae oil, and Fruit storage is not carried out to the algae oil.
Embodiment 5
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (2), environment temperature is 30 DEG C,
Relative humidity is 70%.
Embodiment 6
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
According to the method for embodiment 1 carry out soft capsule preparation, unlike, in step (2), directly by vitamin E with
Algae oil mixing, without being first dissolved in the sunflower oil for being heated to 85 DEG C.
Embodiment 7
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (1), the gelatin is not medicinal
Gelatin, but common gelatin.
Embodiment 8
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (1), the pharmagel is moved
Force value is 150Bloom g.
Embodiment 9
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (1), the pharmagel is moved
Force value is 250Bloom g.
Embodiment 10
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (1), the temperature of colloidal sol is 80
DEG C, steam pressure 0.25MPa, and colloidal sol terminate and cool down after without filtering and Fruit storage.
Embodiment 11
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (3), pelleting environment temperature is 30
DEG C, relative humidity 50%.
Embodiment 12
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (3), the drying is only in humidity
Dry 12h under conditions of being 30 DEG C for 65%, temperature.
Embodiment 13
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (3), the drying is only in humidity
Dry 12h under conditions of being 32 DEG C for 30%, temperature.
Embodiment 14
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (3), obtained soft capsule is existed
Dry 6h under conditions of humidity is 65%, temperature is 30 DEG C；Then dry under conditions of humidity is 30%, temperature is 30 DEG C again
6h。
Embodiment 15
The present embodiment is for illustrating soft capsule provided by the invention and preparation method thereof
The preparation of soft capsule is carried out according to the method for embodiment 1, unlike, in step (3), after soft capsule is dried not
Carry out the cleaning of Residual oil.
Test case 1
(1) discoloration
Discoloration situation is judged by observing the color change of soft capsule, wherein soft capsule is denoted as 10 points to be light yellow, shallowly
Bronzing is denoted as 1 point, wherein score value is lower to show that discoloration is more serious, the results are shown in Table 1.
(2) after the soft capsule for preparing embodiment 1-15 removes from the package, the DHA grease composition of package is obtained, into
Row peroxide value (by ultraviolet specrophotometer, being measured by GB/T24304-2009 method), anisidine value (pass through GB/T
24304-2009 method is measured) and acid value (being measured by GB 5009.229-2016 method) measurement, as a result see
Table 1.
Table 1
| Number | Discoloration | Anisidine value | Peroxide value (meq/kg) | Acid value (mg/g) |
| Embodiment 1 | 10 | 2.5 | 0.5 | 0.2 |
| Embodiment 2 | 10 | 2.3 | 0.8 | 0.3 |
| Embodiment 3 | 10 | 1.9 | 1.2 | 0.6 |
| Embodiment 4 | 8 | 5.3 | 5.1 | 2.5 |
| Embodiment 5 | 6 | 3.6 | 2.1 | 0.9 |
| Embodiment 6 | 7 | 4.2 | 3.2 | 1.4 |
| Embodiment 7 | 9 | 6.5 | 4.2 | 2.3 |
| Embodiment 8 | 5 | 4.8 | 2.5 | 1.1 |
| Embodiment 9 | 7 | 6.2 | 3.1 | 1 |
| Embodiment 10 | 5 | 7.1 | 4.5 | 2.5 |
| Embodiment 11 | 4 | 6.5 | 4.0 | 2.2 |
| Embodiment 12 | 6 | 5.1 | 3.6 | 1.8 |
| Embodiment 13 | 2 | 8.0 | 5.6 | 2.8 |
| Embodiment 14 | 8 | 3.9 | 2.6 | 1.1 |
| Embodiment 15 | 2 | 8.5 | 5.1 | 2.6 |
As can be seen from Table 1, the present invention can prepare the soft capsule for the composition containing DHA grease for meeting different crowds,
Meet requirement of the different crowd to DHA and EPA, maintains the function of infant and teenager's brain, promotes its brain and vision system
The development of system prevents the side effects such as abnormal bleeding and sex premature, while the blood lipid of adjustable person in middle and old age, and it is solidifying to reduce blood
Stagnant degree prevents senile dementia.In addition, can effectively slow down the oxidation of DHA and EPA in grease using method of the invention,
Anisidine value, peroxide number and the acid value for reducing DHA grease composition control the discoloration of soft capsule, increase DHA grease flexible glue
The holding time of capsule.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (11)
1. application of the following DHA grease composition in soft capsule, which is characterized in that the DHA grease composition contains DHA
Grease, the DHA grease contain DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA and EPA
Content ratio be greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content ratio of DHA and EPA are not more than 8:
1。
2. application according to claim 1, wherein the DHA grease composition also contains antioxidant；
Preferably, the antioxidant is selected from least one of vitamin E, lecithin, VC palmitate and rosemary；
Preferably, in the DHA grease composition, the content of the antioxidant is 800-1500ppm；
Preferably, the DHA grease composition also contains edible fats, and the edible fats are preferably selected from walnut oil, purple
At least one of Soviet Union's oil, sunflower oil, evening primrose oil, grape seed oil, soybean oil, linseed oil, rapeseed oil and olive oil.
3. application according to claim 1 or 2, wherein the applicable object of the soft capsule is pregnant and lying-in women, infant and blueness
Teenager, the DHA grease are microbial oil, it is preferred that DHA content >=35 weight % in the microbial oil, it is preferred that
The microbial oil is alga-derived DHA grease；
The applicable object of the soft capsule is person in middle and old age, and the DHA grease contains fish oil or the mixing containing fish oil and algae oil
Object, it is preferred that DHA content >=12 weight % in the fish oil.
4. a kind of preparation method of soft capsule, this method comprises:
(1) water, jelly powder and glycerol are mixed to and carried out colloidal sol, obtains collosol intermixture；
(2) DHA grease composition is poured into the collosol intermixture, obtains soft capsule；
Wherein, the DHA grease composition contains DHA grease, and the DHA grease contains DHA and EPA；
The applicable object of the soft capsule is pregnant and lying-in women, infant and teenager, in the DHA grease composition, DHA and EPA
Content ratio be greater than 12:1；
The applicable object of the soft capsule is person in middle and old age, and in the DHA grease composition, the content ratio of DHA and EPA are not more than 8:
1。
5. according to the method described in claim 4, wherein, the DHA grease composition also contains antioxidant；
Preferably, the antioxidant is selected from least one of vitamin E, lecithin, VC palmitate and rosemary；
Preferably, in the DHA grease composition, the content of the antioxidant is 800-1500ppm；
Preferably, the DHA grease composition also contains edible fats, and the edible fats are preferably selected from walnut oil, purple
At least one of Soviet Union's oil, sunflower oil, evening primrose oil, grape seed oil, soybean oil, linseed oil, rapeseed oil and olive oil；
Preferably, the DHA grease composition is by the way that DHA grease and antioxidant to be mixed to get, the mixed environment temperature
For degree lower than 25 DEG C, relative humidity less than 65%, feed liquid temperature is lower than 30 DEG C；
Preferably, the DHA grease composition being prepared is subjected to Fruit storage；
Preferably, the storage time of the DHA grease composition is not more than 2 hours, and is protected from light storage in an inert atmosphere
It deposits.
6. method according to claim 4 or 5, wherein the applicable object of the soft capsule is pregnant and lying-in women, infant and blueness
Teenager, the DHA grease are microbial oil, it is preferred that DHA content >=35 weight % in the microbial oil, it is preferred that
The microbial oil is alga-derived DHA grease；
The applicable object of the soft capsule is person in middle and old age, and the DHA grease contains fish oil or the mixing containing fish oil and algae oil
Object, it is preferred that DHA content >=12 weight % in the fish oil.
7. according to the method described in claim 4, wherein, in step (1), the condition of the colloidal sol includes: that temperature is 60-85
DEG C, steam pressure is less than 0.2MPa, time 40-50min；
Preferably, after colloidal sol, obtained collosol intermixture is filtered under conditions of 45-75 DEG C at vacuum outgas
Reason, and the collosol intermixture after filtering and Fruit storage is kept the temperature；
Preferably, the storage time of the collosol intermixture is not more than 48 hours；
Preferably, the gelatin is pharmagel；
Preferably, the power value of the gelatin is 180-200Bloom g.
8. according to the method described in claim 4, wherein, in step (2), the condition of the perfusion includes: pelleting environment temperature
It is 18-28 DEG C, relative humidity is not more than 80%, rubber cooling and shaping temperature≤25 DEG C；
Preferably, this method further includes that the soft capsule that will be obtained is dried, and the drying includes the primary drying successively carried out
And redrying；
The condition of the primary drying includes: humidity no more than 80%, and temperature is 26-32 DEG C, and the time is 4-8 hours；
The condition of the redrying includes: humidity no more than 45%, and temperature is 30-45 DEG C, and the time is 4-8 hours；
Wherein, the humidity of primary drying is greater than the humidity of redrying, and the temperature of primary drying is lower than the temperature of redrying；
Preferably, this method includes cleaning the soft capsule after drying to obtained soft capsule using food-grade petroleum ether,
To remove the Residual oil of capsule surface；
Preferably, this method includes washing the soft capsule after drying to obtained capsule using oil suction cloth by rubbing with the hands, substitutes stone
Oily ether cleans to remove the Residual oil of capsule surface.
9. according to the method described in claim 4, wherein, in step (1), relative to the water of 100 parts by weight, the dosage of jelly powder
It is 35-50 parts by weight for 80-120 parts by weight, the dosage of glycerol, the ingredients by weight ratio of glycerol and gelatin is (35-50): 100.
10. the method according to any one of claim 4-8, wherein this method further include: by obtained soft capsule point
Loaded in lighttight Packaging Bottle, equipped with oxygen absorbent in the Packaging Bottle, and bottleneck is sealed using aluminium-foil paper；Or it is soft by what is obtained
Capsule subpackage is in aluminium-plastic panel.
11. the soft capsule that method described in any one of claim 4-10 is prepared, wherein the soft capsule is applied to
Infant, the teenager consumer groups different with person in middle and old age, peroxide value≤15meq/kg, acid value≤3mg/ in the soft capsule
G, anisidine value≤15.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811506742.6A CN109463762A (en) | 2018-12-10 | 2018-12-10 | Application and soft capsule and preparation method thereof of the DHA grease composition in soft capsule |
| PCT/CN2019/101031 WO2020119164A1 (en) | 2018-12-10 | 2019-08-16 | Use of dha oil composition in soft capsule, and soft capsule and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811506742.6A CN109463762A (en) | 2018-12-10 | 2018-12-10 | Application and soft capsule and preparation method thereof of the DHA grease composition in soft capsule |
Publications (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020119164A1 (en) * | 2018-12-10 | 2020-06-18 | 瞿瀚鹏 | Use of dha oil composition in soft capsule, and soft capsule and preparation method therefor |
| WO2020119165A1 (en) * | 2018-12-10 | 2020-06-18 | 瞿瀚鹏 | Application of dha grease composition to gelatin sweet, and gelatin sweet and preparation method therefor |
| CN113519847A (en) * | 2021-07-28 | 2021-10-22 | 宁波天皓生物科技有限公司 | Production process of DHA algae oil product |
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| MA41611A (en) * | 2015-02-23 | 2018-01-02 | Omthera Pharmaceuticals Inc | MILLI-CAPSULE PREPARATIONS CONTAINING FREE POLYINSATURATED FATTY ACIDS |
| CN109463512A (en) * | 2018-12-10 | 2019-03-15 | 瞿瀚鹏 | Application and gel candy and preparation method thereof of the DHA grease composition in gel candy |
| CN109463762A (en) * | 2018-12-10 | 2019-03-15 | 瞿瀚鹏 | Application and soft capsule and preparation method thereof of the DHA grease composition in soft capsule |
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| CN1927050A (en) * | 2006-09-18 | 2007-03-14 | 汕头市润科生物工程有限公司 | DHA microcapsule food additives, DHA soft capsule health product and uses thereof |
| CN103156198A (en) * | 2013-04-03 | 2013-06-19 | 上海春芝堂生物制品有限公司 | Fish oil soft capsules and preparation method thereof |
| CN104055123A (en) * | 2014-05-25 | 2014-09-24 | 宁波市成大机械研究所 | Gamma-linolenic acid containing deep sea fish oil soft capsule |
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| WO2020119164A1 (en) * | 2018-12-10 | 2020-06-18 | 瞿瀚鹏 | Use of dha oil composition in soft capsule, and soft capsule and preparation method therefor |
| WO2020119165A1 (en) * | 2018-12-10 | 2020-06-18 | 瞿瀚鹏 | Application of dha grease composition to gelatin sweet, and gelatin sweet and preparation method therefor |
| CN113519847A (en) * | 2021-07-28 | 2021-10-22 | 宁波天皓生物科技有限公司 | Production process of DHA algae oil product |
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| WO2020119164A1 (en) | 2020-06-18 |
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