CN109444302A - The separation of human body acetone, ethyl alcohol based on gas-chromatography and detection system and method - Google Patents
The separation of human body acetone, ethyl alcohol based on gas-chromatography and detection system and method Download PDFInfo
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title claims abstract description 292
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 197
- 235000019441 ethanol Nutrition 0.000 title claims abstract description 105
- 238000001514 detection method Methods 0.000 title claims abstract description 79
- 238000004817 gas chromatography Methods 0.000 title claims abstract description 61
- 238000000926 separation method Methods 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title abstract description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 134
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 67
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 67
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 6
- 230000005526 G1 to G0 transition Effects 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 229910018487 Ni—Cr Inorganic materials 0.000 claims description 3
- 238000005452 bending Methods 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000009434 installation Methods 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 abstract description 94
- 239000012535 impurity Substances 0.000 abstract description 5
- 230000037361 pathway Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 229960004424 carbon dioxide Drugs 0.000 description 54
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 13
- 238000007689 inspection Methods 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000012159 carrier gas Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001871 ion mobility spectroscopy Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010018473 Glycosuria Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- -1 carbon dioxide Ketone Chemical class 0.000 description 1
- 229910002090 carbon oxide Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001211 electron capture detection Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000824 selected ion flow tube mass spectrometry Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fats And Perfumes (AREA)
Abstract
Human body acetone based on gas-chromatography, the separation of ethyl alcohol and detection system and method, belong to field of gas detection, corresponding sense channel is able to enter in order to solve separation gas, each sense channel is independent of each other and each channel is only by a kind of separation gas, prevent multiple gases from leading to the problem of impurity interference by shared pathway sequentially in time in detection-phase, main points be include gas-chromatography splitter (1), two-bit triplet solenoid valve, sense channel and sensor, the two-bit triplet solenoid valve includes the first three-way magnetic valve (2), second three-way magnetic valve (4), each solenoid valve has input valve port and two output valve ports, the sense channel includes carbon dioxide sense channel (3), acetone sense channel (5) and ethyl alcohol sense channel (6), effect is: avoiding gaseous impurity influence.
Description
Technical field
The invention belongs to field of gas detection, are related to the separation and inspection of a kind of the human body acetone based on gas-chromatography, ethyl alcohol
Examining system and method.
Background technique
Breathing acetone in human body respiration gas is a kind of VOC gas of low concentration.The organic gas is highly soluble in water, and
It is easy and gas chromatography phase separation, detection difficult, the bad control of detection accuracy.The study found that breathing acetone is detection glycosuria
The biomarker of disease.Carrying out sample detecting to the breathing acetone gas of diabetic in medicine being capable of real-time monitoring patient
State of an illness data and the contact wound of patient can be reduced.There are many technologies of breathing acetone detection at present.Including gas
Phase chromatography-mass spectroscopy (GC-MS), proton translocation-mass spectrography (PTR-MS), ion mobility spectrometry (IMS), selection ion flow pipe matter
Spectral technology (SIFT-MS), electronic nose laser spectrum tech.Conventional gas-phase chromatograph is generally by air-channel system, sampling system, separation
System, temperature control system and Measurement data-processing system composition.In use, after analysis sample is gasified in injection port, by carrier gas
It brings chromatographic column into, by there is the chromatographic column of different retention properties to component in mixture to be detected, separates each component, successively lead
Enter detector, to obtain the detection signal of each component.According to the precedence for importing detector, by comparison, it is possible to distinguish go out
It is any component, each component content can be calculated according to peak heights or peak area.The detector generallyd use has: Thermal Conductivity
Device, flame ionization detector, helium ionization detector, supersonic detector, photoionization detector, electron capture detection
Device, flame photometric detector, electrochemical detector, mass detector etc..In above scheme, each component by separation there is still a need for pair
Its component is determined, also, the detection and calculating of component and its content are complex.
Summary of the invention
It is able to enter corresponding sense channel in order to solve separation gas, each sense channel is independent of each other and each channel
By a kind of separation gas, prevent multiple gases from generating impurity interference by shared pathway sequentially in time in detection-phase
The problem of, the following technical solutions are proposed: a kind of separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol by the present invention
System, including gas-chromatography splitter, two-bit triplet solenoid valve, sense channel and sensor, the two-bit triplet solenoid valve packet
The first three-way magnetic valve, the second three-way magnetic valve are included, each solenoid valve has input valve port and two output valve ports, and the detection is logical
Road includes carbon dioxide sense channel, acetone sense channel and ethyl alcohol sense channel, and the sensor includes carbon dioxide sensing
The inlet end of device, acetone sensor and ethanol sensor, the gas-chromatography splitter connects air inlet, gas-chromatography splitter
Gas outlet connect the input valve port of the first three-way magnetic valve, the output valve port one of the first three-way magnetic valve connects carbon dioxide inspection
Channel is surveyed, carbon dioxide sense channel gas outlet connects carbon dioxide sensor, and the output valve port two of the first three-way magnetic valve connects
The input valve port of the second three-way magnetic valve is connect, the output valve port one of the second three-way magnetic valve connects acetone sense channel, acetone inspection
It surveys channel gas outlet and connects acetone sensor, the output valve port two of the second three-way magnetic valve connects ethyl alcohol sense channel, ethyl alcohol inspection
It surveys channel gas outlet and connects ethanol sensor.
Further, the separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol, further includes monolithic
Machine, the carbon dioxide sensor, acetone sensor and ethanol sensor are all connected with an input port of single-chip microcontroller, described
One delivery outlet of single-chip microcontroller connects display circuit, and the single-chip microcontroller connect with each three-way magnetic valve, fallen by the single-chip microcontroller
Timing simultaneously ends the starting control signal for issuing solenoid valve in timing, and receives control signal by corresponding three-way magnetic valve to open
Open corresponding output valve port.
Further, the split tunnel of the gas chromatographic column is the glass straight tube of several head and the tail bending connection, and separation is logical
Road length is 2m, internal diameter 2mm, and stationary phase coats polyethylene glycol in column.
Further, the sensor includes shell pipe and detection circuit, and detection circuit is mounted in shell pipe, detection
Circuit is concentric and successively covers the insulating layer of connection, Au electrode, gas sensitive material, and Ni-Cr heater strip is installed in insulating layer,
Electrode width 0.1mm, shell pipe diameter 1mm.
A kind of separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol, measuring at a certain temperature,
Breathing gas respectively is isolated by the time of carbon dioxide, acetone and alcohol gas by gas-chromatography splitter, and with the time
Determine that each solenoid valve after breathing gas enters gas-chromatography splitter, respectively inputs valve port and exports the switch time of valve port, with
So that different separation gas is separated under corresponding temperature, it can be opened and be incited somebody to action in corresponding disengaging time by corresponding valve
A kind of gas enters its corresponding sense channel, and enters corresponding sensor.
Further, the gas-chromatography splitter carries out gas separation to the breathing gas of input, obtains breathing gas
In carbon dioxide, acetone and alcohol gas, two-bit triplet solenoid valve exists the carbon dioxide isolated, acetone and alcohol gas
Corresponding disengaging time is opened by corresponding valve, is entered in corresponding sense channel, sensor is to two isolated
Carbonoxide, acetone and alcohol gas carry out quantitative acquisition and detection, and send data to single-chip microcontroller, will be acquired by single-chip microcontroller
Data are shown.
Further, at 25 DEG C carbon dioxide in 60s when be kept completely separate, acetone divides completely in 300s
From ethyl alcohol has been kept completely separate in 630s, and at 25 DEG C, the output valve port one of the first three-way magnetic valve is opened in 0-60s, defeated
Valve port two is opened in 61-630s out, and the output valve port one of the second three-way magnetic valve is opened in 61-300s, and output valve port two exists
301-630s is opened；
At 40 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 230s, and ethyl alcohol exists
It has been kept completely separate when 360s；At 40 DEG C, the output valve port one of the first three-way magnetic valve is opened in 0-60s, and output valve port two exists
61-360s is opened, and the output valve port one of the second three-way magnetic valve is opened in 61-230s, and output valve port two is opened in 231-360s
It opens；
At 60 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 150s, and ethyl alcohol exists
It has been kept completely separate when 240s；At 60 DEG C, the output valve port one of the first three-way magnetic valve is opened in 0-60s, and output valve port two exists
61-240s is opened, and the output valve port one of the second three-way magnetic valve is opened in 61-150s, and output valve port two is opened in 151-240s
It opens；
At 80 DEG C carbon dioxide in 30s when be kept completely separate, acetone has been kept completely separate in 72s, and ethyl alcohol exists
It has been kept completely separate when 120s；At 80 DEG C, the output valve port one of the first three-way magnetic valve one is opened in 0-30s, exports valve port two
It is opened in 31-120s, the output valve port one of the second three-way magnetic valve two is opened in 31-72s, exports valve port two in 73-120s
It opens.
Further, solenoid valve controls its on-off by single-chip microcontroller, to control the switch of sense channel, the single-chip microcontroller with
Its timer function realize time counting and timing time reach and to solenoid valve issue control signal and drive magnetic valve open
It closes.
The utility model has the advantages that being isolated after breathing gas of the present invention separates post separation by gas-chromatography with gas-chromatography splitter
The time of above-mentioned three kinds of gas is different, is used in conjunction using two-stage electromagnetic valve, different time is separated the control of output valve port
Gas is able to enter unique passage, only avoids common sense channel before and after time sequencing by this kind of gas in the channel
The phenomenon that passing through, checked for impurities caused to be interfered, and multiple sense channels correspond to multiple sensors, sensor can independent detection,
Compared to existing common sense channel with time sequencing with gas with various is gone out, need to connect corresponding inspection according to outlet to pipeline
It surveying, the present invention does not need to distinguish detected components, autonomous channel, standalone sensor detection, so that system structure pipeline is directly fixed, energy
It is enough that sensor detection directly is carried out to separation gas in different occasions, it is suitable for drunk driving, hospital's detection etc., and without manually existing
Different detection sensors are replaced in detection, detection is caused to be fluctuated.
Detailed description of the invention
Fig. 1 is human body acetone, the separation of ethyl alcohol and the functional block diagram of detection system based on gas-chromatography.
Fig. 2 is sense channel schematic diagram.
Fig. 3 is the disengaging time of gas-chromatography split tunnel at different temperatures to carbon dioxide, acetone and ethyl alcohol.Figure
In: disengaging time when a curve is 25 DEG C, disengaging time when b curve is 40 DEG C, disengaging time when c curve is 60 DEG C, d
Disengaging time when curve is 80 DEG C.
Fig. 4 is in 80 DEG C of time gas chromatography split tunnels as carbon dioxide, acetone and concentration of alcohol increase gradient point
From the curve of time.In figure: a curve is+0.1 μ l acetone of 10 μ l carbon dioxide and ethyl alcohol；B curve is 20 μ l carbon dioxide+0.2
μ l acetone and ethyl alcohol；C curve is+0.3 μ l acetone of 30 μ l carbon dioxide and ethyl alcohol；D curve is+0.4 μ l third of 40 μ l carbon dioxide
Ketone and ethyl alcohol；E curve is+0.5 μ l acetone of 50 μ l carbon dioxide and ethyl alcohol.
Fig. 5 be 80 DEG C of time gas chromatography split tunnels gas concentration lwevel be 20 μ l, acetone and concentration of alcohol liter
The curve of high gradient disengaging time.In figure: a curve is 0.1 μ l acetone and ethyl alcohol；B curve is 0.2 μ l acetone and ethyl alcohol；C curve
It is 0.3 μ l acetone and ethyl alcohol；D curve is 0.4 μ l acetone and ethyl alcohol；E curve is 0.5 μ l acetone and ethyl alcohol.
Fig. 6 be 60 DEG C of time gas chromatography split tunnels gas concentration lwevel be 20 μ l, acetone and concentration of alcohol liter
The curve of high gradient disengaging time.In figure: a curve is 0.3 μ l acetone and ethyl alcohol；B curve is 0.4 μ l acetone and ethyl alcohol；C curve
It is 0.5 μ l acetone and ethyl alcohol.
Fig. 7 is the sectional view of gas-chromatography splitter.
Fig. 8 is the structural schematic diagram of sensor.
Wherein: 1. gas-chromatography splitters, 2. first three-way magnetic valves, 3. carbon dioxide sense channels, 4. second threeways
Solenoid valve, 5. acetone sense channels, 6. ethyl alcohol sense channels, 7. carbon dioxide sensors, 8. acetone sensors, 9. ethyl alcohol sensing
Device, 10. single-chip microcontrollers, the gas outlet of 11. gas-chromatography splitters, the output valve port one of 12. first three-way magnetic valves, 13. first
The output valve port two of three-way magnetic valve, the input valve port of 14. second three-way magnetic valves, the delivery valve of 15. second three-way magnetic valves
Mouth one, the output valve port two of 16. second three-way magnetic valves.
Specific embodiment
Embodiment 1: as illustrated in fig. 1 and 2, a kind of separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol,
Including gas-chromatography splitter 1, two-bit triplet solenoid valve, sense channel and sensor, the two-bit triplet solenoid valve includes
First three-way magnetic valve 2, the second three-way magnetic valve 4, each solenoid valve have input valve port and two output valve ports, and the detection is logical
Road includes carbon dioxide sense channel 3, acetone sense channel 5 and ethyl alcohol sense channel 6, and the sensor includes that carbon dioxide passes
The inlet end of sensor 7, acetone sensor 8 and ethanol sensor 9, the gas-chromatography splitter 1 connects air inlet, gas-chromatography
The gas outlet 11 of splitter connects the input valve port of the first three-way magnetic valve 2, and the output valve port 1 of the first three-way magnetic valve connects
Carbon dioxide sense channel 3 is connect, 3 gas outlet of carbon dioxide sense channel connects carbon dioxide sensor 7, the first three-way magnetic valve
Output valve port 2 13 connect the input valve port 14 of the second three-way magnetic valve, the output valve port 1 of the second three-way magnetic valve connects
Acetone sense channel 5,5 gas outlet of acetone sense channel connect acetone sensor 8, the output valve port 2 16 of the second three-way magnetic valve
Ethyl alcohol sense channel 6 is connected, 6 gas outlet of ethyl alcohol sense channel connects ethanol sensor 9.
By above-mentioned, the present invention is a kind of common detection for acetone and ethyl alcohol, can be used for the acetone detection of hospital,
It can be used for the ethyl alcohol detection of drunk driving, and in drunk driving detection, additionally it is possible to acetone detection direct for more drivers, for sugar
The early detection of urine disease has important influence, and diabetic, which should be avoided, does Professional drivers, has both been unfavorable for the control of diabetes,
Also be unfavorable for traffic safety, thus, for driver's drunk driving detection in, can simultaneously for the marker detection of diabetes, have compared with
After important prevention and meaning, breathing gas being reminded to separate post separation by gas-chromatography, isolated with gas-chromatography splitter
The time of above-mentioned three kinds of gas is different, is used in conjunction using two-stage electromagnetic valve, different time is separated the control of output valve port
Gas is able to enter unique passage, only avoids common sense channel before and after time sequencing by this kind of gas in the channel
The phenomenon that passing through, checked for impurities caused to be interfered, and multiple sense channels correspond to multiple sensors, sensor can independent detection,
Compared to existing common sense channel with time sequencing with gas with various is gone out, need to connect corresponding inspection according to outlet to pipeline
It surveying, the present invention does not need to distinguish detected components, autonomous channel, standalone sensor detection, so that system structure pipeline is directly fixed, energy
It is enough that sensor detection directly is carried out to separation gas in different occasions, it is suitable for drunk driving, hospital's detection etc., and without manually existing
Different detection sensors are replaced in detection, detection is caused to be fluctuated.
The separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol, further include single-chip microcontroller 10, described
Carbon dioxide sensor 7, acetone sensor 8 and ethanol sensor 9 be all connected with an input port of single-chip microcontroller 10, the list
One delivery outlet of piece machine 10 connects display circuit, and the single-chip microcontroller 10 is connect with each three-way magnetic valve, by the single-chip microcontroller
10 countdowns simultaneously end the starting control signal for issuing solenoid valve in timing, and receive control signal by corresponding three-way magnetic valve
To open corresponding output valve port, which is used to the control of solenoid valve being implemented in automatic control, thus, detection has realized
Full-automation, breathing gas, which enters, starts timing by single-chip microcontroller, and the control for issuing respective valves is reached in different timings
Signal processed, thus, it realizes automatic gas passage and independently exports.
The separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol, point of the gas chromatographic column
From the glass straight tube that channel is the bending connection of several head and the tail, split tunnel length is 2m, internal diameter 2mm, and stationary phase coating is poly- in column
Ethylene glycol.
The separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol, the sensor includes shell
Body pipe and detection circuit, detection circuit are mounted in shell pipe, and detection circuit is concentric and successively covers the insulating layer of connection, Au
Electrode, gas sensitive material, insulating layer is interior to install Ni-Cr heater strip, electrode width 0.1mm, shell pipe diameter 1mm.Air-sensitive material
Material: the sensitive material for changing resistance value can be changed according to certain gas concentration.The corresponding gas sensitive of above-mentioned gas belongs to existing
There is technology, be selected as the gas sensitive of corresponding detection gas, belongs to ordinary skill in the art selection.And it can be to above-mentioned
The sensor of gas detection belongs to the prior art, and the present embodiment provides the sensors that one kind can heat, and detection is enabled to tie up
It is held in a certain temperature, improves detection accuracy.
A kind of separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol, measuring at a certain temperature,
Breathing gas respectively is isolated by the time of carbon dioxide, acetone and alcohol gas by gas-chromatography splitter 1, and with the time
Determine that each solenoid valve after breathing gas enters gas-chromatography splitter 1, respectively inputs valve port and exports the switch time of valve port, with
So that different separation gas is separated under corresponding temperature, it can be opened and be incited somebody to action in corresponding disengaging time by corresponding valve
A kind of gas enters its corresponding sense channel, and enters corresponding sensor.
The separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol, the gas-chromatography splitter 1
Gas separation is carried out to the breathing gas of input, obtains carbon dioxide, acetone and alcohol gas in breathing gas, two-bit triplet
The carbon dioxide isolated, acetone and alcohol gas are opened in corresponding disengaging time by corresponding valve by solenoid valve,
It enters in corresponding sense channel, sensor carries out quantitative acquisition to the carbon dioxide, acetone and alcohol gas isolated
With detection, and single-chip microcontroller 10 is sent data to, data will be acquired by single-chip microcontroller 10 and shown.
The separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol,
At 25 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 300s, and ethyl alcohol exists
It has been kept completely separate when 630s, at 25 DEG C, the output valve port 1 of the first three-way magnetic valve is opened in 0-60s, exports valve port two
It is opened in 61-630s, the output valve port 1 of the second three-way magnetic valve is opened in 61-300s, exports valve port two in 301-
630s is opened；
At 40 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 230s, and ethyl alcohol exists
It has been kept completely separate when 360s；At 40 DEG C, the output valve port 1 of the first three-way magnetic valve is opened in 0-60s, exports valve port two
It is opened in 61-360s, the output valve port 1 of the second three-way magnetic valve is opened in 61-230s, exports valve port two in 231-
360s is opened；
At 60 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 150s, and ethyl alcohol exists
It has been kept completely separate when 240s；At 60 DEG C, the output valve port 1 of the first three-way magnetic valve is opened in 0-60s, exports valve port two
It is opened in 61-240s, the output valve port 1 of the second three-way magnetic valve is opened in 61-150s, exports valve port two in 151-
240s is opened；
At 80 DEG C carbon dioxide in 30s when be kept completely separate, acetone has been kept completely separate in 72s, and ethyl alcohol exists
It has been kept completely separate when 120s；At 80 DEG C, the output valve port one of the first three-way magnetic valve 2 one is opened in 0-30s, exports valve port
Two open in 31-120s, and the output valve port one of the second three-way magnetic valve 4 two is opened in 31-72s, export valve port two in 73-
120s is opened.
The separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol, solenoid valve are controlled by single-chip microcontroller 10
Its on-off is made, to control the switch of sense channel, the single-chip microcontroller 10 is by its timer function realization time counting and in terms of
When the time reach and to solenoid valve issue control signal and drive magnetic valve switch.
Embodiment 2: traditional gas chromatograph is big with gas source occupied space, chromatography column volume is too long, detector rapid wear
Bad and disadvantage easy to pollute needs the protection of carrier gas, and works in clean environment, this is resulted in some particular surroundings
Conventional gas-phase chromatograph is used with unsuitable under working condition.But these technologies some there are detection method trouble, be not easy to
The problem of carrying.As shown in Figure 1, the present embodiment provides a kind of human body acetone respirometer based on gas-chromatography, including gas phase color
Compose splitter 1, two-bit triplet solenoid valve, sense channel, sensor detection and display circuit.The gas-chromatography splitter 1 is used
In carrying out gas separation to the mixed gas of input, carbon dioxide, acetone and alcohol gas in breathing gas are obtained；Described two
Position-3-way solenoid valve is that the carbon dioxide, acetone and alcohol gas that will be isolated enter corresponding inspection in corresponding disengaging time
It surveys in channel；The sensor detection circuit is to be carried out using sensor to the carbon dioxide, acetone and alcohol gas isolated
Quantitative detection；The detection circuit is containing for the carbon dioxide that be will test out using single-chip microcontroller 10, acetone and alcohol gas
Amount is shown on single-chip microcontroller 10.
The gas-chromatography splitter 1 is the spiral shape glass column of 2m long, and bore 2mm, coating stationary phase is poly- second
Glycol.Front end connects air inlet, and rear end connects the first three-way magnetic valve 2.The two-bit triplet solenoid valve is two two-bit triplets
Solenoid valve.First three-way magnetic valve 2 includes input valve port, output valve port one, output valve port two, the gas of input valve port connection front end
The outlet of phase chromatography column 1, output valve port one connect carbon dioxide sense channel 3, output valve port two connects two-bit triplet the
The input valve port 14 of two three-way magnetic valves；Second three-way magnetic valve 4 includes input valve port, output valve port one, exports valve port two, defeated
Enter the output valve port two of valve port connection valve one, output valve port one connects acetone sense channel 5, and output valve port two connects ethyl alcohol detection
Channel 6.The gas sensor, carbon dioxide gas sensor are placed in carbon dioxide sense channel 3；Acetone gas sensing
Device is placed in acetone sense channel 5；Alcohol gas sensor is placed in ethyl alcohol sense channel 6.The single-chip microcontroller 10, is used to
Show the content of the carbon dioxide, acetone and the ethyl alcohol that detect.
The course of work includes such as the next stage: gas separation phase: breathing gas is blown into gas-chromatography split tunnel, benefit
With gas-chromatography principle, carbon dioxide, acetone and alcohol gas are separated.The time-shared switch stage: breathing gas passes through
Gas-chromatography split tunnel respectively is isolated by carbon dioxide, acetone and alcohol gas in different times.Pass through two-bit triplet
The switch of valve allows three kinds of gases to enter in corresponding sense channel.Two-bit triplet solenoid valve is switched by single-chip microcontroller 10
Control.As shown in Figure 3 at 25 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 300s,
Ethyl alcohol has been kept completely separate in 630s；At 40 DEG C carbon dioxide in 60s when be kept completely separate, acetone in 230s
It is kept completely separate, ethyl alcohol has been kept completely separate in 360s；At 60 DEG C carbon dioxide in 60s when be kept completely separate, acetone exists
It has been kept completely separate when 150s, ethyl alcohol has been kept completely separate in 240s；Divide completely when at 80 DEG C, carbon dioxide is in 30s
From acetone has been kept completely separate in 72s, and ethyl alcohol has been kept completely separate in 120s.So the first threeway electromagnetism at 25 DEG C
The output valve port 1 of valve is opened in 0-60s, and output valve port two is opened in 61-630s, the output valve port of the second three-way magnetic valve
One opens in 61-300s, and output valve port two is opened in 301-630s；The output valve port one of the first three-way magnetic valve at 40 DEG C
12 open in 0-60s, and output valve port two is opened in 61-360s, and the output valve port one of the second three-way magnetic valve is opened in 61-230s
It opens, output valve port two is opened in 231-360s；At 60 DEG C, the output valve port 1 of the first three-way magnetic valve is opened in 0-60s,
It exports valve port two to open in 61-240s, the output valve port one of the second three-way magnetic valve is opened in 61-150s, exports valve port two
It is opened in 151-240s；At 80 DEG C, the output valve port 1 of the first three-way magnetic valve is opened in 0-30s, and output valve port two exists
31-120s is opened, and the output valve port one of the second three-way magnetic valve is opened in 31-72s, and output valve port two is opened in 73-120s.
Solenoid valve is controlled by single-chip microcontroller 10, by single-chip microcontroller 10 to the on-off of solenoid valve, thus the switch of control channel.Detect rank
Section: by three kinds of carbon dioxide, acetone and ethyl alcohol gas sensors to carbon dioxide, acetone and the ethyl alcohol in breathing gas
Carry out quantitative detection.The display stage: gas sensor is connected with single-chip microcontroller 10, will by the display screen of single-chip microcontroller 10
The content of carbon dioxide, acetone and ethyl alcohol is shown.
The preferable specific embodiment of the above, only the invention, but the protection scope of the invention is not
It is confined to this, anyone skilled in the art is in the technical scope that the invention discloses, according to the present invention
The technical solution of creation and its inventive concept are subject to equivalent substitution or change, should all cover the invention protection scope it
It is interior.
Claims (8)
1. a kind of separation and detection system of the human body acetone based on gas-chromatography, ethyl alcohol, which is characterized in that including gas-chromatography
Splitter (1), two-bit triplet solenoid valve, sense channel and sensor, the two-bit triplet solenoid valve include the one or three energization
Magnet valve (2), the second three-way magnetic valve (4), each solenoid valve has input valve port and two output valve ports, the sense channel include
Carbon dioxide sense channel (3), acetone sense channel (5) and ethyl alcohol sense channel (6), the sensor include that carbon dioxide passes
The inlet end of sensor (7), acetone sensor (8) and ethanol sensor (9), the gas-chromatography splitter (1) connects air inlet,
Gas-chromatography splitter gas outlet (11) connection the first three-way magnetic valve (2) input valve port, the first three-way magnetic valve it is defeated
Valve port one (12) connection carbon dioxide sense channel (3) out, carbon dioxide sense channel (3) gas outlet connect carbon dioxide sensing
Device (7), the output valve port two (13) of the first three-way magnetic valve connect the input valve port (14) of the second three-way magnetic valve, the second threeway
The output valve port one (15) of solenoid valve connects acetone sense channel (5), and acetone sense channel (5) gas outlet connects acetone sensor
(8), the output valve port two (16) of the second three-way magnetic valve connects ethyl alcohol sense channel (6), and ethyl alcohol sense channel (6) gas outlet connects
Connect ethanol sensor (9).
2. the separation and detection system of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as described in claim 1
In further including single-chip microcontroller (10), the carbon dioxide sensor (7), acetone sensor (8) and ethanol sensor (9) connect
An input port of single-chip microcontroller (10) is connect, a delivery outlet of the single-chip microcontroller (10) connects display circuit, the monolithic
Machine (10) is connect with each three-way magnetic valve, ends the starting control of sending solenoid valve by the single-chip microcontroller (10) countdown and in timing
Signal processed, and control signal is received to open corresponding output valve port by corresponding three-way magnetic valve.
3. the separation and detection system of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as described in claim 1
In the split tunnel of the gas chromatographic column is the glass straight tube of several head and the tail bending connection, and split tunnel length is 2m, internal diameter
2mm, stationary phase coats polyethylene glycol in column.
4. the separation and detection system of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as described in claim 1
In, the sensor includes shell pipe and detection circuit, and detection circuit is mounted in shell pipe, detection circuit be it is concentric and by
Insulating layer, the Au electrode, gas sensitive material of layer covering connection, the interior installation Ni-Cr heater strip of insulating layer, electrode width 0.1mm,
Shell pipe diameter 1mm.
5. a kind of separation and detection method of the human body acetone based on gas-chromatography, ethyl alcohol, which is characterized in that measuring is one
Determine at temperature, breathing gas by gas-chromatography splitter (1) respectively be isolated by carbon dioxide, acetone and alcohol gas when
Between, and determine that each solenoid valve after breathing gas enters gas-chromatography splitter (1), respectively inputs valve port and delivery valve with the time
The switch time of mouth can be divided by corresponding valve accordingly so that different separation gas is separated under corresponding temperature
It is opened from the time and a kind of gas is entered into its corresponding sense channel, and enter corresponding sensor.
6. the separation and detection method of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as claimed in claim 5
In the gas-chromatography splitter (1) carries out gas separation to the breathing gas of input, obtains the titanium dioxide in breathing gas
Carbon, acetone and alcohol gas, two-bit triplet solenoid valve separate the carbon dioxide isolated, acetone and alcohol gas accordingly
Time is opened by corresponding valve, is entered in corresponding sense channel, and sensor is to carbon dioxide, the acetone isolated
Quantitative acquisition and detection are carried out with alcohol gas, and sends data to single-chip microcontroller (10), number will be acquired by single-chip microcontroller (10)
According to display.
7. the separation and detection method of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as claimed in claim 6
In,
At 25 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 300s, and ethyl alcohol is in 630s
It has been be kept completely separate that, at 25 DEG C, the output valve port one (12) of the first three-way magnetic valve is opened in 0-60s, and output valve port two exists
61-630s is opened, and the output valve port one (15) of the second three-way magnetic valve is opened in 61-300s, exports valve port two in 301-
630s is opened；
At 40 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 230s, and ethyl alcohol is in 360s
It has been kept completely separate；At 40 DEG C, the output valve port one (12) of the first three-way magnetic valve is opened in 0-60s, and output valve port two exists
61-360s is opened, and the output valve port one (15) of the second three-way magnetic valve is opened in 61-230s, exports valve port two in 231-
360s is opened；
At 60 DEG C carbon dioxide in 60s when be kept completely separate, acetone has been kept completely separate in 150s, and ethyl alcohol is in 240s
It has been kept completely separate；At 60 DEG C, the output valve port one (12) of the first three-way magnetic valve is opened in 0-60s, and output valve port two exists
61-240s is opened, and the output valve port one (15) of the second three-way magnetic valve is opened in 61-150s, exports valve port two in 151-
240s is opened；
At 80 DEG C carbon dioxide in 30s when be kept completely separate, acetone has been kept completely separate in 72s, and ethyl alcohol is in 120s
It has been kept completely separate；At 80 DEG C, the output valve port one of the first three-way magnetic valve (2) one is opened in 0-30s, and output valve port two exists
31-120s is opened, and the output valve port one of the second three-way magnetic valve (4) two is opened in 31-72s, exports valve port two in 73-120s
It opens.
8. the separation and detection method of human body acetone, ethyl alcohol based on gas-chromatography, feature exist as claimed in claim 7
In solenoid valve controls its on-off by single-chip microcontroller (10), and to control the switch of sense channel, the single-chip microcontroller (10) is with its timing
Device function realizes time counting and reaches in timing time and issue control signal and drive magnetic valve switch to solenoid valve.
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