CN109432293A - A kind of Chinese medicinal granule and preparation method thereof for treating cardiovascular and cerebrovascular disease - Google Patents
A kind of Chinese medicinal granule and preparation method thereof for treating cardiovascular and cerebrovascular disease Download PDFInfo
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- 208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 32
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 29
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 26
- 239000008187 granular material Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000000706 filtrate Substances 0.000 claims abstract description 46
- 241000208340 Araliaceae Species 0.000 claims abstract description 37
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 37
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 37
- 235000008434 ginseng Nutrition 0.000 claims abstract description 37
- 238000000605 extraction Methods 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 30
- 239000000843 powder Substances 0.000 claims abstract description 30
- 230000001954 sterilising effect Effects 0.000 claims abstract description 24
- 239000004375 Dextrin Substances 0.000 claims abstract description 22
- 229920001353 Dextrin Polymers 0.000 claims abstract description 22
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 22
- 235000019425 dextrin Nutrition 0.000 claims abstract description 22
- 229940013618 stevioside Drugs 0.000 claims abstract description 22
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000019202 steviosides Nutrition 0.000 claims abstract description 22
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 21
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 21
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 21
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 21
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 21
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 21
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 21
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 21
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 21
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 21
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 20
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
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- 239000006286 aqueous extract Substances 0.000 claims abstract description 15
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- -1 polyethylene Polymers 0.000 claims abstract description 12
- 229920000573 polyethylene Polymers 0.000 claims abstract description 12
- 238000003860 storage Methods 0.000 claims abstract description 12
- 238000005469 granulation Methods 0.000 claims abstract description 10
- 230000003179 granulation Effects 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 6
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 5
- 235000019441 ethanol Nutrition 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 25
- 238000002156 mixing Methods 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
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- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a kind of Chinese medicinal granules and preparation method thereof for treating cardiovascular and cerebrovascular disease, it include following substance, 130-200 parts of ginseng, 130-200 parts of Radix Astragali, 180-220 parts of Radix Salviae Miltiorrhizae, 130-200 parts of hawthorn, Radix Ophiopogonis 130-200 part, 80-120 parts of Schisandra chinensis, 80-120 parts of Rhizoma Chuanxiong, 30-60 parts of dextrin, 10-30 parts of stevioside according to weight item；The following steps are included: step 1: weighing ginseng, coarse crushing, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick material card, seals, and storage please be tested；Step 2: Schisandra chinensis, Radix Salviae Miltiorrhizae are put into extraction tank, and filtration merges to obtain the first filtrate；First filtrate is pumped into vacuum concentrator, alcohol medicinal extract is obtained；It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into vacuum concentrator, aqueous extract is obtained；Step 3: ginseng fine powder, dextrin, the stevioside of predetermined weight are weighed；Step 4: granulation drying steps five: grain step 6: total mix is selected.
Description
Technical field
The present invention relates to pharmaceutical field more particularly to a kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease and its preparation sides
Method.
Background technique
According to " 2012 world health statistical report " that the World Health Organization announces, cardiovascular disease, cancer, chronic respiratory system
The non-communicable diseases such as system disease, diabetes have become the health threat of 21 century human maximum, lead to ten thousand people more than 3600 every year
Lose life.Data show that the morbidity of China's cardiovascular disease (heart disease, stroke) and the death rate are in lasting raised bench always
Section, national cardiovascular patient about 2.3 hundred million people die of about 3,000,000 people of cardiovascular disease every year, almost every dead 3 people
In just there is 1 people to be cardiovascular disease, average 340 people of cardiovascular death per hour.More it is disturbing that, according to data statistics 2020
Year, China will be every year because the number of cardiovascular disease death will likely reach 4,000,000.The treatment quarter of cardiovascular disease is not allowed
It is slow.
Currently, the active drug of home and abroad treatment cardiovascular and cerebrovascular disease is seldom, mostly tablet, injection.Its Chinese and Western medicine, treasure
Your Chinese herbal medicine is more, and medication cycle is long, expensive, and curative effect is poor.General character Chinese medicine prescription is more, and complementation is poor, curative effect
It not protruding, especially repeats to change dosage form, production cost increases, and it is palliative after patient takes for a long time, it takes then disease and gently, stops
It repeats to aggravate with the then state of an illness.
Summary of the invention
The purpose of the present invention is to propose to a kind of Chinese medicinal granules and preparation method thereof for the treatment of cardiovascular and cerebrovascular disease.
To achieve the goals above, present invention employs following technical solutions:
A kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease includes following substance, ginseng 130-200 according to weight item
Part, 130-200 parts of Radix Astragali, 180-220 parts of Radix Salviae Miltiorrhizae, 130-200 parts of hawthorn, Radix Ophiopogonis 130-200 part, 80-120 parts of Schisandra chinensis, river
80-120 parts of rhizome of chuanxiong, 30-60 parts of dextrin, 10-30 parts of stevioside.
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
Further, the ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.
Further, Schisandra chinensis, Radix Salviae Miltiorrhizae in the step 2 are put into extraction tank 85% alcohol reflux that 8 times of amounts are added
Extract secondary, first time extraction 3 hours, second of extraction 1.5 hours.
Further, in the step 2 in the second filter vacuum inspissator, it is concentrated into relative density 1.15~1.20, temperature
20 DEG C of degree.
Further, Radix Ophiopogonis in the step 2, Radix Astragali, Rhizoma Chuanxiong, hawthorn is put into extraction tank plus 10 times of amount water decoctions 2
It is secondary, 2.5 hours for the first time, second 1.5 hours.
Further, the second filtrate is pumped into vacuum concentrator in the step 2, is concentrated into relative density 1.08
~1.12, after temperature 60 C, medical fluid is added in Alcohol-settling tank, 85% ethyl alcohol of equivalent is added while stirring, it is quiet after being sufficiently stirred
It sets overnight, filters off sediment, filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.3, and 80 DEG C of temperature,
Further, it pelletizes in the step 4 through 14 mesh of oscillating granulator
Further, dry under the conditions of in the step 4 80 DEG C ± 2 in fluid bed granulator.
Further, dry particl is subjected to choosing grain in the step 5, crosses 12,40 meshes.
The disease treatment means traditional as China, Chinese patent drug occupy quite heavy in the market in China's cardiovascular and cerebrovascular medication
The position wanted.And prescription of the present invention be by Song Jin period Li Gao " differentiation on endogenous " in Shengmai Yin side be added Radix Salviae Miltiorrhizae, Radix Astragali,
Rhizoma Chuanxiong and hawthorn four traditional Chinese medicine composition, the QI invigorating qi-restoratives of the medicine, function of promoting blood circulation to disperse blood clots are more prominent compared with Shengmai Yin.As heart and brain
The advantage drug of vascular diseases treatment, invention formulation, will be with broader market hairs under the support of numerous industrial policies
Open up space.
Detailed description of the invention
Fig. 1 is production procedure schematic diagram of the invention；
Specific embodiment
Described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Embodiment 1:
A kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease includes following substance, 130 parts of ginseng, Huang according to weight item
130 parts of stilbene, 180 parts of Radix Salviae Miltiorrhizae, 130 parts of hawthorn, 130 parts of Radix Ophiopogonis, 80 parts of Schisandra chinensis, 80 parts of Rhizoma Chuanxiong, 30 parts of dextrin, stevioside 10
Part.
Embodiment 2:
A kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease includes following substance, 200 parts of ginseng, Huang according to weight item
200 parts of stilbene, 220 parts of Radix Salviae Miltiorrhizae, 200 parts of hawthorn, 200 parts of Radix Ophiopogonis, 120 parts of Schisandra chinensis, 120 parts of Rhizoma Chuanxiong, 60 parts of dextrin, stevioside 30
Part.
Embodiment 3:
A kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease includes following substance, 150 parts of ginseng, Huang according to weight item
150 parts of stilbene, 200 parts of Radix Salviae Miltiorrhizae, 150 parts of hawthorn, 150 parts of Radix Ophiopogonis, 100 parts of Schisandra chinensis, 100 parts of Rhizoma Chuanxiong, 45 parts of dextrin, stevioside 20
Part.
Embodiment 4:
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
Embodiment 5:
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
The ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.
Embodiment 6:
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
The ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.Schisandra chinensis, Radix Salviae Miltiorrhizae in the step 2, investment
85% alcohol reflux that 8 times are measured is added in extractor and extracts secondary, first time extraction 3 hours, second of extraction 1.5 hours.Institute
It states in step 2 in the second filter vacuum inspissator, is concentrated into relative density 1.15~1.20,20 DEG C of temperature.In the step 2
Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn is put into extraction tank plus 10 times of amount water decoct 2 times, and 2.5 hours for the first time, second 1.5 hours.
The second filtrate is pumped into vacuum concentrator in the step 2, is concentrated into relative density 1.08~1.12, after temperature 60 C,
Medical fluid is added in Alcohol-settling tank, 85% ethyl alcohol of equivalent is added while stirring, after being sufficiently stirred, stands overnight, filters off sediment,
Filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.3, and 80 DEG C of temperature.
Embodiment 7:
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
The ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.Schisandra chinensis, Radix Salviae Miltiorrhizae in the step 2, investment
85% alcohol reflux that 8 times are measured is added in extractor and extracts secondary, first time extraction 3 hours, second of extraction 1.5 hours.Institute
It states in step 2 in the second filter vacuum inspissator, is concentrated into relative density 1.15~1.20,20 DEG C of temperature.In the step 2
Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn is put into extraction tank plus 10 times of amount water decoct 2 times, and 2.5 hours for the first time, second 1.5 hours.
The second filtrate is pumped into vacuum concentrator in the step 2, is concentrated into relative density 1.08~1.12, after temperature 60 C,
Medical fluid is added in Alcohol-settling tank, 85% ethyl alcohol of equivalent is added while stirring, after being sufficiently stirred, stands overnight, filters off sediment,
Filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.3, and 80 DEG C of temperature, through 14 mesh system of oscillating granulator in the step 4
Grain.It is dry under the conditions of in the step 4 80 DEG C ± 2 in fluid bed granulator.
Embodiment 8:
A kind of preparation method of Chinese medicinal granule that treating cardiovascular and cerebrovascular disease, comprising the following steps:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；It is dense that first filtrate is pumped into vacuum
In contracting device, alcohol medicinal extract is obtained；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into
Into vacuum concentrator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The object mixed is taken by several times
Material is added in wet granulator, and aqueous extract, alcohol medicinal extract is added, and pelletizes after stirring through oscillating granulator, wet granular is transferred to boiling
It rises dry in granulator；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
The ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.Schisandra chinensis, Radix Salviae Miltiorrhizae in the step 2, investment
85% alcohol reflux that 8 times are measured is added in extractor and extracts secondary, first time extraction 3 hours, second of extraction 1.5 hours.Institute
It states in step 2 in the second filter vacuum inspissator, is concentrated into relative density 1.15~1.20,20 DEG C of temperature.In the step 2
Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn is put into extraction tank plus 10 times of amount water decoct 2 times, and 2.5 hours for the first time, second 1.5 hours.
The second filtrate is pumped into vacuum concentrator in the step 2, is concentrated into relative density 1.08~1.12, after temperature 60 C,
Medical fluid is added in Alcohol-settling tank, 85% ethyl alcohol of equivalent is added while stirring, after being sufficiently stirred, stands overnight, filters off sediment,
Filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.3, and 80 DEG C of temperature, through 14 mesh system of oscillating granulator in the step 4
It is dry under the conditions of in the grain step 4 80 DEG C ± 2 in fluid bed granulator.Dry particl is subjected to choosing grain, mistake in the step 5
12,40 mesh.
Embodiment 9:
Step 1: pre-treatment:
Qualified crude drug is got by production instruction order, material requistion, and net medicinal material library is sent into after pre-treatment.Raw material is medicine materical crude slice
Can directly feed intake (if medicinal material is complete shape, must feed intake after coarse crushing) after the assay was approved.
It sterilizes, pulverize and sieve:
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick
Material card seals, and storage please be tested.
Step 2: it extracts, concentration
Schisandra chinensis, Radix Salviae Miltiorrhizae are got by production ordering, weight and material card content is checked and whether material object is consistent, after errorless,
It is put into extraction tank, the 85% alcohol reflux extraction that 8 times of amounts are added is secondary, extracts 3 hours for the first time, and it is small to extract 1.5 for the second time
When, filtration, merging filtrate；Filtrate is pumped into vacuum concentrator, is operated as required, relative density 1.15~1.20 is concentrated into
(20 DEG C), obtain alcohol medicinal extract, are fitted into clean turnover barrel, weigh, stick material card, are put in storage.
Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn are got by production ordering, weight and material card content is checked and whether material object is consistent,
It after errorless, is put into extraction tank, 10 times of amount water is added to decoct 2 times, 2.5 hours for the first time, second 1.5 hours, filtration merged filter
Liquid；Filtrate is pumped into vacuum concentrator, is operated as required, after being concentrated into relative density 1.08~1.12 (60 DEG C), by medicine
Liquid is added in Alcohol-settling tank, and 85% ethyl alcohol of equivalent is added while stirring, after being sufficiently stirred, stands overnight, and filters off sediment, filtrate
Recycling ethyl alcohol is simultaneously concentrated into relative density 1.30~1.36 (80 DEG C), obtains the water extracted immersing paste, is fitted into clean turnover barrel, is weighed, patch
Upper material card, storage.
Step 3: ingredient is weighed
According to batch production orderings, ginseng pulverate, dextrin, stevioside are weighed, is fitted into polyethylene plastic bag, sticks material card,
Sealing, clears out a gathering place.
Step 4: granulation drying
Load weighted material is set in total mix machine after mixing, is dispensed, material card is pasted in weighing；It takes and mixes by several times
Material is set in wet granulator, and the water extracted immersing paste, alcohol-extracted extract is added, and is stirred to agglomerating, touching the i.e. scattered softwood held.Through waving
The granulation of 14 mesh of granulator.Wet granular is transferred in fluid bed granulator, it is dry under the conditions of 80 DEG C ± 2.
Step 5: grain is selected
Dry particl is subjected to choosing grain, crosses 12,40 meshes, chooses intermediate particle, be incorporated in the stainless steel barrel of inner bag (or dress
Enter in polyethylene plastic bag), it weighs, and stick material card in exterior and interior packing, seals, clear out a gathering place.
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, mixes, particle is incorporated with to the stainless steel barrel of inner bag after mixing
In or be fitted into polyethylene plastic bag, weigh, and stick material card, seal, clear out a gathering place, enter intermediate station, please test.
Packing
Aluminum-plastic composite membrane is installed, hopper is added in particle, is packed, every bag of 4g, weighs once within every 30 minutes, controls its loading amount
Within acceptability limit (± 6.5%), the bagged product of Proper Packing is fitted into Turnround basket difference, is sticked material card, is transmitted to
Outer packing please test.
Outsourcing
Packaging material, product to be packaged are got by batch packaging directive, capsule, specification press tag control, check name of an article sum number
Amount.
Printing lot number: batch number, date of manufacture and validity period are set in the corresponding position spray printing of capsule, is done easy to remember
Record.Big case stamps batch number, date of manufacture, valid until printed words in the corresponding position in side.
Packaging operation: drug is packed into capsule together with specification；Plastic packaging, barcode scanning are packed into big case, storage, to be tested.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease, it is characterised in that: according to weight item include following substance, ginseng
130-200 parts, 130-200 parts of Radix Astragali, 180-220 parts of Radix Salviae Miltiorrhizae, 130-200 parts of hawthorn, Radix Ophiopogonis 130-200 part, Schisandra chinensis 80-
120 parts, 80-120 parts of Rhizoma Chuanxiong, 30-60 parts of dextrin, 10-30 parts of stevioside.
2. a kind of preparation method for the Chinese medicinal granule for treating cardiovascular and cerebrovascular disease, it is characterised in that: the following steps are included:
Step 1: it sterilizes, pulverize and sieve
Ginseng, coarse crushing are weighed, sterilizing is ground into 80 mesh fine powders, is fitted into polyethylene plastic bag after sterilizing, weigh, stick material
Card seals, and storage please be tested；
Step 2: it extracts, concentration
It by Schisandra chinensis, Radix Salviae Miltiorrhizae, is put into extraction tank, filters, merge to obtain the first filtrate；First filtrate is pumped into vacuum concentrator
In, obtain alcohol medicinal extract；
It by Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, is put into extraction tank, filters, merge to obtain the second filtrate；Second filtrate is pumped into very
In empty inspissator, aqueous extract is obtained；
Step 3: ingredient is weighed
Weigh ginseng fine powder, dextrin, the stevioside of predetermined weight；
Step 4: granulation drying
Load weighted ginseng fine powder, dextrin, stevioside are added in total mix machine after mixing；The material mixed is taken to add by several times
Enter in wet granulator, and aqueous extract, alcohol medicinal extract is added, pelletize after stirring through oscillating granulator, wet granular is transferred to boiling system
It is dry in grain machine；
Step 5: grain is selected
Dry particl is subjected to choosing grain, is sieved, intermediate particle is chosen, is weighed；
Step 6: total mix
The particle for selecting grain to finish is taken, is added in mixing machine, is mixed, particle is obtained after mixing.
3. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
The ginseng after sterilizing is ground into 80 mesh fine powders in the step 1.
4. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
Schisandra chinensis, Radix Salviae Miltiorrhizae in the step 2, the 85% alcohol reflux extraction for being put into extraction tank 8 times of amounts of addition is secondary, mentions for the first time
It takes 3 hours, second of extraction 1.5 hours.
5. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
In the step 2 in the second filter vacuum inspissator, it is concentrated into relative density 1.15~1.20,20 DEG C of temperature.
6. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
Radix Ophiopogonis, Radix Astragali, Rhizoma Chuanxiong, hawthorn, which are put into extraction tank, in the step 2 adds 10 times of amount water to decoct 2 times, and 2.5 hours for the first time, the
Secondary 1.5 hours.
7. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
The second filtrate is pumped into vacuum concentrator in the step 2, is concentrated into relative density 1.08~1.12, after temperature 60 C,
Medical fluid is added in Alcohol-settling tank, 85% ethyl alcohol of equivalent is added while stirring, after being sufficiently stirred, stands overnight, filters off sediment,
Filtrate recycling ethanol is simultaneously concentrated into relative density 1.30~1.3, and 80 DEG C of temperature.
8. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
It pelletizes in the step 4 through 14 mesh of oscillating granulator.
9. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, which is characterized in that
It is dry under the conditions of in the step 4 80 DEG C ± 2 in fluid bed granulator.
10. a kind of preparation method of Chinese medicinal granule for treating cardiovascular and cerebrovascular disease according to claim 2, feature exist
In dry particl is carried out choosing grain in the step 5, crosses 12,40 meshes.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1692932A (en) * | 2005-04-11 | 2005-11-09 | 安徽科创中药天然药物研究所有限责任公司 | Method for preparing traditional Chinese medicine |
| CN101804151A (en) * | 2010-03-23 | 2010-08-18 | 中山尊隆药业有限公司 | Method for preparing Yixinshu tablets |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1692932A (en) * | 2005-04-11 | 2005-11-09 | 安徽科创中药天然药物研究所有限责任公司 | Method for preparing traditional Chinese medicine |
| CN101804151A (en) * | 2010-03-23 | 2010-08-18 | 中山尊隆药业有限公司 | Method for preparing Yixinshu tablets |
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