CN109431596B

CN109431596B - High-frequency cancer therapeutic instrument using body resistance characteristic

Info

Publication number: CN109431596B
Application number: CN201811005093.1A
Authority: CN
Inventors: 韩成镐
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-08-30
Filing date: 2018-08-30
Publication date: 2021-12-07
Anticipated expiration: 2038-08-30
Also published as: CN109431596A

Abstract

A high frequency cancer therapeutic apparatus using body resistance characteristics, comprising a power supply part for obtaining and supplying electric energy, or, supplying electric energy; the oscillating part is connected with the power supply part and is used for generating high-frequency current; the adjusting part is connected with the oscillating part and comprises an amplifying part connected with the oscillating part, and the amplifying part is used for amplifying the obtained high-frequency current; the output part is connected with the regulating part and is used for outputting high-frequency current; and a first electrode part and a second electrode part respectively connected with the output part, wherein the first electrode part and the second electrode part are used for contacting with the body and generating current with opposite polarities. The high-frequency current obtained by the application is 0.3-0.7MHz, deep heat of 40-45 ℃ is generated in a body, and the heat can be used for directionally eliminating tumor cells or shrinking the tumor cells.

Description

High-frequency cancer therapeutic instrument using body resistance characteristic

The technical field is as follows:

the present application relates to a high frequency cancer therapeutic apparatus using body resistance characteristics.

Background art:

when a general high-frequency current is applied to a human body, molecules constituting tissues vibrate and rub against each other every time the direction of the current changes, and as a result, the body tissues generate heat sensation, which is called deep heat.

Unlike other types of electric current, high-frequency electric current can heat a specific part in body tissue without stimulating sensory nerves or motor nerves or causing muscle contraction. The high frequency energy converted into body heat can increase body tissue temperature, enhance cell function, increase blood flow through the dilation of arteries and capillaries, promote blood and lymph circulation, and promote metabolism.

Typical high frequency treatment devices are used for the treatment of skin diseases, where relatively high frequencies are required. For example, the high frequency current frequency is now recognized to be about 13MHz, and most of the high frequency current frequency is 6-8MHz smaller than this. In this case, the heat generation phenomenon excessively occurs in the surface layer of the skin, and the heat sensation does not occur deep inside the body, so that the site where the cancer cell is present is not greatly affected.

The application contents are as follows:

the application provides a high frequency cancer therapeutic instrument using body resistance characteristics, which adopts the technical scheme for solving the technical problems that:

a high frequency cancer therapeutic apparatus using body resistance characteristics, comprising a power supply part for obtaining and supplying electric energy, or, supplying electric energy;

the oscillating part is connected with the power supply part and is used for generating high-frequency current;

the adjusting part is connected with the oscillating part and comprises an amplifying part connected with the oscillating part, and the amplifying part is used for amplifying the obtained high-frequency current;

the output part is connected with the regulating part and is used for outputting high-frequency current;

and a first electrode part and a second electrode part respectively connected with the output part, wherein the first electrode part and the second electrode part are used for contacting with the body and generating current with opposite polarities.

Preferably, the device further comprises a control part, and the control part is respectively connected with the power supply part, the oscillation part, the regulation part and the output part in a control mode.

Preferably, the adjusting part further comprises a level adjusting part for adjusting the intensity of the high-frequency current.

Preferably, the adjusting part further comprises a horizontal adjusting part, the horizontal adjusting part is used for adjusting the intensity of the high-frequency current, and the horizontal adjusting part is connected with the controller.

Preferably, the high-frequency current is a current of 0.3MHz to 0.7 MHz.

Preferably, the high frequency current is a current of 0.46 MHz.

Preferably, the device further comprises a receptor detection part for detecting the state temperature of a predetermined position of the receptor.

Preferably, the state temperature is used for controlling the frequency of the high-frequency current, and if the state temperature is lower than a predetermined temperature, the frequency of the high-frequency current is increased, and if the state temperature is higher than the predetermined temperature, the frequency of the high-frequency current is decreased.

Preferably, the predetermined position is a position which is 7-15cm away from the outer surface of the receptor by taking the outer surface of the receptor as a reference.

Preferably, the predetermined temperature is 40 ℃.

The application adopts the technology, the obtained high-frequency current is 0.3-0.7MHz, deep heat of 40-45 ℃ is generated in a body, and the heat can be used for directionally eliminating or shrinking tumor cells. For general cells, because the rest of the cells are connected with blood vessels, blood can take away part of heat, and tumor cells are not connected with the blood vessels, so that when a thermal load occurs, the tumor cells can not dissipate the heat to the outside, and can be heated to necrotize, the tumor cells can be effectively eliminated by utilizing the principle, and in the treatment process, because the high-frequency current is selected to be 0.3-0.7MHz and mainly concentrated below 3cm of skin, the skin or subcutaneous burn of a treated object can be effectively prevented.

Description of the drawings:

FIG. 1 is a photograph of the present invention.

FIG. 2 is a control block diagram of the high frequency cancer therapy device of the present application.

FIG. 3(a) is a drawing showing the operation of a conventional high frequency treatment apparatus.

FIG. 3(b) is a drawing showing the operation of the high frequency treatment apparatus of the present invention.

Fig. 4(a) and (b) are diagrammatic drawings showing the polarity reversal of cells in vivo according to the switching of the first electrode part and the second motor part in the radiofrequency therapy apparatus of the present application.

Fig. 5(a) and (b) are circuit diagrams of the body.

Fig. 6(a) is a photograph of the state of the body taken with a thermal imaging camera with the body temperature at 35 ℃.

Fig. 6(b) is a photograph of the body state taken with the thermal imaging camera in the case where the body temperature is 39 ℃.

FIG. 7 is a graph of cell survival rate as a function of temperature.

FIG. 8(a) is a graph showing a comparison of survival rates of cancer cells and normal cells heated at 43 ℃ according to the presence or absence of blood flow.

FIG. 8(b) is a graph showing the change in blood flow when cancer cells and normal cells are heated.

FIG. 9(a) shows the state of change in the case of heating of normal cells.

FIG. 9(b) shows the state of change in the case of heating cancer cells.

Fig. 10 is a graph and a relational expression illustrating a relationship between a frequency and a depth of a heat generating portion.

FIG. 11 is a photograph showing the actual experiment of the present invention.

Fig. 12 is data obtained from the experimental results of fig. 11.

FIG. 12(a) is a graph showing the change in body temperature at each measurement site within 60 minutes using the high-frequency cancer therapy device of the present invention.

FIG. 12(b) is a graph showing the measurement during 30 minutes of residual heat collection at the end of the experiment.

FIG. 13 is a table showing the body temperature changes at each measurement site within 60 minutes using the device for treating a high-frequency cancer of the present invention.

FIG. 14 is a table of data determined during 30 minutes of residual heat after the end of the experiment.

FIG. 15 is a photograph of an experimental set for measuring deep heat generation state using an experimental article having similar characteristics to the human body for a therapeutic apparatus for high-frequency cancer according to the present invention.

Fig. 16 is a photograph of an experiment performed by using the pork for the experimental set shown in fig. 15 as an experimental article.

Fig. 17 is a graph of experimental result data obtained using fig. 16.

FIG. 18 is a photograph of an experiment using the bean curd for experimental set shown in FIG. 15 as a setting for experimental articles.

Fig. 19 is a graph of experimental result data obtained using fig. 18.

FIG. 20 is a photograph of an experiment using the bean jelly for experimental set shown in FIG. 15 as a setting for experimental articles.

FIG. 21 is a graph showing data of the results of the experiment using FIG. 20, in the case where NaCl was contained in an amount of 0.5%.

Fig. 22 is a graph of experimental result data obtained by using fig. 20 in the case where nacl0.5% is not included.

FIG. 23 is CT photographs taken before and after treatment of a patient as demonstrated in case 1 of success of treatment with a high frequency cancer therapeutic apparatus according to the present application.

FIG. 24 shows the state data before and after treatment of patients in case 1 of success of treatment with the high frequency cancer therapy apparatus according to the present application.

FIG. 25 is CT photographs taken before and after treatment of patients as demonstrated in case 3 of success of treatment with a high frequency cancer therapeutic apparatus according to the present application.

FIG. 26 is a CT photograph of a patient before and after treatment of successful case 3 of the treatment of the high frequency cancer according to the present application.

FIG. 27 is a graph showing the data of pancreatic cancer markers in case 3, which is the success of the treatment with the high frequency cancer therapy apparatus according to the present application.

The specific implementation mode is as follows:

in order to clearly explain the technical features of the present invention, the present application will be explained in detail by the following embodiments in combination with the accompanying drawings.

The application can be changed in various ways, has various implementation cases, and shows and explains the specific implementation case on the drawing. However, this application is not limited to the specific embodiments, and all changes, including technical changes, equivalent and alternative embodiments, can be understood to be included in the scope of the present application. Description of various components including ordinal numbers and terms such as 1 st, 2 nd, etc. may be used, but the components are not limited to the above terms. The above-described term components are used for the purpose of distinction only, starting with other components. For example, a 2 nd component is named a 1 st component and a similar 1 st component is named a 2 nd component without departing from the scope of the present application. And/or the term is a combination of plural related description items or a combination of plural related description items including one item. When some components are "connected" or "linked" to each other among different components, the components may be directly connected to other components or links or may have other components, but other components may exist in the middle. In some components, "directly connected" or "directly linked" to each other, there may be different components in between. The terminology used in the description presented herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. Singular references are expressly different in context and encompass plural expressions.

In the present application, the terms "including" or "having" or the like are used to designate the presence of one or more other features, numbers, phases, operations, components, parts or the presence of these combinations as described in the list, and the presence or possibility of addition of one or more other features, phases, operations, components, parts or the presence of these combinations is not to be understood in advance.

Hereinafter, the detailed description will be given with reference to the accompanying drawings, and the same or corresponding components, regardless of the reference numerals, will be given the same reference numerals, and the overlapping description thereof will be omitted.

As shown in the drawings of fig. 1 and 2, the present application relates to a radiofrequency cancer therapy device (hereinafter referred to as a radiofrequency cancer therapy device) utilizing body resistance characteristics, which is attached to a main body (10), wherein a body to be treated is connected to the main body (10) and brought into close contact with a first electrode unit (200), and a second electrode unit (300) is disposed at a position opposite to the first electrode unit (200) in response to the treatment by the 1 st electrode unit (200).

The first electrode unit (200) and the second electrode unit (300) have a periodic polarity inversion characteristic, and generate heat energy by passing a high-frequency current through the body using the resistance characteristic of the body, thereby moving cell molecules in the body to deep parts of the body (for example, about 7 to 15cm on the skin surface).

The main body (10) is connected with the casing (11), various keys or handles and an operation part (12) are prepared on the casing (11), a display (not shown) for showing the starting state of the therapeutic device or the therapeutic field state of the therapeutic object person is prepared, and the 1 st connecting line and the 2 nd pole part power supply and signal receiving and transmitting signals which are connected with the casing (11) comprise the 2 nd connecting line.

A1 st connecting line in the body (10) is inserted into the 1 st connecting port (21), and a 2 nd connecting line is inserted into the 2 nd connecting port (22).

The first electrode part (200) is a wrist part (220) which the therapist can hold in his hand, and a 1 st electrode plate (210) including the lower surface of the wrist part, and a 1 st connector (230) into which a 1 st connection port (21) at the end of the 2 nd connection line is inserted is prepared.

The second electrode part includes a 2 nd electrode plate (310) prepared in a wide screen state, and reference numeral 330 denotes a 2 nd connector into which the 2 nd connection port (22) is inserted at the 2 nd connection line end part.

The 1 st electrode plate (210) and the 2 nd electrode plate (330) are directly attached to the surface of the human body.

FIG. 2 is a block diagram of the present application of a high frequency cancer treatment device.

The working example according to the application shows that the high-frequency cancer treatment equipment enables the high-frequency current output generated by the high-frequency current to comprise a power supply part (110), an oscillation part (120), an amplification part (130), a level adjustment part (140) and a power output part (150).

The power supply unit (110) is a unit that supplies power to the components of the high-frequency generation module (100), and when the high-frequency current oscillates in the oscillation unit (120), the amplification unit (130) plays a role of increasing the oscillating high-frequency current in the oscillation unit (120).

The level adjustment unit (140) adjusts the intensity of the high-frequency current, and the output unit (150) outputs the high-frequency current at a predetermined intensity. The high frequency current output by the output unit (150) is in the range of 300kHz to 700kHz (0.3MHz to 0.7MHz), and the high frequency current substituted in this way is recognized inside the body by the first electrode unit (200) and the second electrode unit (300).

The above components are control reception start operations of the control unit (160).

In the case of the present application, the frequency is about 0.3-0.7MHz, and the wavelength is 600-700m if the period is 2000-2200 nm. In more detail, the present application is 0.46MHz, the period is 2174nm, and the wavelength is 652.2 m.

In contrast, according to the conventional high frequency treatment apparatus, the frequency of 8MHz and the cycle of 125nm are set to 37.5m, and the cycle of the high frequency treatment apparatus having the frequency of 13.56MHz is set to 73nm and the wavelength is set to 22.1 m.

Or, in the case of a 70MHz frequency treatment device, the period is 14nm-7nm and the wavelength is 4.3-2.1 nm.

The second electrode portion (310) of the second electrode portion (300) is activated using the ground terminal. When the 1 st electrode plate (210) of the first electrode part (200) passes the high-frequency current approved by the body and the corresponding first electrode part (200) passes the (+) current approval, the 2 nd electrode plate (310) of the second electrode part (300) is activated by the terminal (-), and when the 1 st electrode plate of the first electrode part passes the (-) current approval, the 2 nd electrode plate (+) of the second electrode part is activated by the terminal.

Fig. 3(a) is a diagram of a method for generating heat in the body by using a high-frequency RF method (Capacitive) according to the conventional technique, and fig. 3(b) is a diagram for generating deep heat in the body by using a high-frequency current living body resistor according to the present invention.

The body has both the capacitor (capacitor) characteristic and the resistor (resistor) characteristic, and the mold (a) is limited to one direction in which the body is placed, as in the case of the conventional device using high frequency waves at 8MHz or 13.56 MHz. This is the mode in which rf (radio frequency) generates deep heat in a human body heating body.

In this case, the skin temperature is inevitably required to be lowered in order to raise the temperature of the deep portion more remarkably than when the temperature is raised on the skin surface or under the skin in the deep portion (specified to 7 to 15cm from the skin depth), and therefore, a cooling device (e.g., a water storage bag) is separately installed.

However, RF is necessary to make the machine high-powered by this cooling device because of the reduced reaction of the output power.

In addition, as shown in fig. 3(a), the mold (a) generates an electric field in one direction only in a radial direction around the mold (a) to generate heat. That is, generation of the heat sensation from the subcutaneous layer is a method of transmitting the heat sensation to the deep portion.

As described above, the current generated by the electric field flows to the skin and thus the heat is hardly raised to a high temperature (for example, 40 to 43 ℃) by being concentrated in the skin or the deep part of the subcutaneous layer, and there is a risk that the skin is burned by a high output rate or by sudden generation of intense heat under the skin.

Fig. 3(b) shows a resistive (resistive) system according to the present invention. The resistive system is a method in which the electrodes are in contact with the body for recognition, and the body generates frictional heat by the periodic switching of the current flow and polarity between the electrodes of the resistor body and the switching of the current flow direction, such as the rapid vibration, the rotational motion, the twisting, and the collision motion of ions and molecules in the cells traveling in the body as shown in fig. 4. In fig. 4 the probe is the first electrode part (200) in the present application and the electrode plate is the second electrode part (300).

The high frequency occurring in the present radiofrequency cancer therapy device is 0.3-0.7MHz, and more particularly 0.46 MHz.

The present invention is directed to uniformly heat a skin layer or a subcutaneous layer at a site where electricity is applied to a body, and does not require relatively low output for cooling, and does not cause a patient to suffer from pain and increase the temperature of a deep part of the body.

The frequency current of 100kHz or more is effective for body fever, and 300kHz or more can be obtained intracellularly, or the resistance of tumor tissue is about half lower than that of normal tissue by about 700kHz or more, and the frequency is almost the same.

Also, the resistance of the human body is 100-1K Ω, and the capacitance is 100-100pF cut-off frequency of about 800KHz at minimum. In combination, a frequency of between 300KHz may be directly affected in the cell for the treatment of cancer and 700KHz may be used for tumor tissue with a lower resistance than normal tissue. The resistance of tumor tissue is lower than normal tissue and the current is more circulating in the tumor and therefore more heat is generated.

As shown in fig. 5(a), the human body is a model in which a complex resistance and capacitance are formed to constitute a line complex circuit, and cancer cells and normal cells are regarded as parallel circuits, and the resistance of cancer cells is lower than that of normal cells. As shown in fig. 5(b), even if the electric resistance is low in the parallel circuit, the heat generation amount is recognized to be higher than that of normal cell cancer cells even if the same current is used.

The treatment method of the high-frequency cancer treatment equipment simultaneously realizes the effects of immunotherapy and thermotherapy, the human autoimmune cells (NK cells) are increased by 5-15 times when the body temperature rises to 1 ℃, and the strengthened immunity attacks the cancer cells, so the immunotherapy is called by utilizing the principle that the cancer cells are gradually eliminated.

On the other hand, a treatment method in which cancer cells are destroyed by exposure to a high temperature than a temperature above a necrosis point of the cells is called thermotherapy. The normal cells disperse heat by vasodilatation, and the cancer cells do not disperse heat by not dilating and do not gradually eliminate the cancer cells by the heat sensation.

The high-frequency cancer treatment equipment can increase the temperature of the deep part to be more than 42 ℃ so as to increase the immunity, and can be used for treating patients by utilizing the principle that the cancer cells are killed by heat.

Fig. 6(a) shows a state of being photographed by a thermal imaging camera when the body temperature is 35 ℃, and fig. 6(b) shows a state of being photographed by a thermal imaging camera when the body temperature is 39 ℃. When the body temperature is lower than 35 ℃, weakness and dyspepsia are induced, and metabolism is lowered due to tingling and pain caused by muscle contraction and blood circulation retardation. The average temperature of cancer patients is around 35 ℃. This phenomenon, immunity is only 30% of normal body temperature (36.5 ℃).

On the other hand, the immunity is more than 5 times of the average immunity when the body temperature is more than 37 ℃. In this case, the blood circulation is smooth, and metabolism is more active by promoting cell activity. In addition, various organs of the body are very active, and damaged cells can be repaired by activation of the cells.

FIG. 7 is a graph of cell survival as a function of temperature [ Dewey WC, Hopwood LE, Sapareto LA, et al.Cellular responses to combinations of hyperthermia and radiation.Radiology.1997; 123:463-474 with permission.

Cancer cells began to necrose when all cells in a state of not being connected to the surroundings were subjected to 50 minutes at 42 ℃. However, when the temperature of normal cells rises, the normal cells are connected to each other, and heat is dissipated to the outside by the blood flow of blood vessels to prevent necrosis, and cancer cells are not dissipated to the outside or are necrotic due to the blood flow.

FIG. 8(a) is a graph showing a comparison of survival rates of cancer cells and normal cells when heated to 43 ℃ in accordance with the presence or absence of blood flow, and FIG. 8(b) is a graph showing a change in blood flow rate when the cancer cells and normal cells are heated.

The left graph of FIG. 8(a) shows that normal cells and cancer cells at 43 ℃ are killed by heat after a lapse of time in a state where the blood flow is not flowing. However, as shown in the right graph of fig. 8(a), the blood continues to live at 43 ℃ while flowing due to heat dissipation from normal cells to the outside through the blood stream, and cancer cells are killed by the inability to utilize the blood stream.

As shown in fig. 8(b), the blood flow volume of cancer cells is rather decreased during heating, and normal cells disappear by heating as shown above because the blood flow volume increases during heating, and normal cells can survive.

Fig. 9(a) shows a state of change when the normal cells are heated, and fig. 9(b) shows a state of change when the cancer cells are heated.

As shown in fig. 9(a), since the blood vessels of normal cells and the blood vessels connected to the new blood vessels can be heated, the blood vessels of normal cells and the blood vessels connected to the normal cells are expanded to increase the blood flow, and thus the heat obtained in the normal cells flows out through the blood vessels, and if the heating is interrupted, the re-contraction can be restored to the normal state.

However, as shown in fig. 9(b), since the blood vessels owned by the cancer cells may be connected to the new blood vessels, the cancer cells may be heated, and the heat cannot flow out. Cancer cells can only be necrotized by heat. Further, when a high-frequency current is applied, the heating value of the cancer cell is larger than that of the normal cell because the resistance of the cancer cell is smaller than that of the normal cell as described above. Therefore, this may also be a feature of inducing rapid necrosis of cancer cells by heat.

Fig. 10 is a graph showing the frequency and the depth of a heat generating region, and the effect of deep heat generation is limited if the depth of invasion is shallow as the frequency becomes lower.

The reference of the depth of the heat-generating portion herein is a temperature of 42 ℃ means the measured depth, and fig. 10 can calculate the depth thereof by the calculation formula.

The practical meaning of the commonly used thermotherapy, namely 13.56MHz, that the penetration depth is not more than 10-20mm, is that the heating temperature is only concentrated in the deep part below the subcutaneous part and can not be transmitted.

Or, other products are used, the degree ratio of the penetration depth of the product is about 50-70mm under the condition of 8MHz, and the degree ratio of 13.56MHz is 13. Although the relative depth is deep in the case of 56MHz, it is clear that this effect is limited with respect to a deep part of 100mm or more.

However, the 0.46MHz used in the present application means that the temperature (42 ℃) occurs in a deep part of the body in the sense that the permeability exceeds 150mm compared with other products, and thus means that the thermotherapy is effective in the execution in the deep cells.

Fig. 11 is a photograph of an actual experimental scene of whether deep heat is generated in the case of the high-frequency cancer therapy system according to the present invention, and fig. 12 shows data obtained by this experiment.

This experiment was carried out using 3 sterile pigs at the animal model center of the university of medical college, gazelle medical science, and it was determined whether deep heat could be raised to a significant extent using the radiofrequency cancer therapy device of the present application.

As shown in fig. 11, after the subject pig was anesthetized, the blood flow rate of the pig was measured (first), and before the experiment, the blood flow rate and blood flow volume of the portal vein of the liver were measured by ultrasonic waves after the experiment (second), a thermometer was inserted into the upper right quadrant (RUQL) near the liver, the upper left quadrant (LUQS) near the stomach, the center of the abdomen (MA) near the small intestine, the subcutaneous fat layer (ScM) at the center of the abdomen, and the vicinity of the lower abdominal bladder (LAU) before the start of the experiment. ③ the result of temperature measurement before the experiment of the high frequency cancer treatment equipment, the temperature near the stomach is 36.4 ℃, the temperature near the liver is 36.6 ℃, the temperature near the center of the abdomen is 36.9 ℃, the temperature near the subcutaneous fat layer in the center of the abdomen is 36.1 ℃ and the temperature near the bladder is 35.9 ℃.

Fourthly, after the high-frequency cancer treatment equipment is started for 60 minutes, the deep heat rise temperature change is recorded every 10 minutes. Over 60 minutes, the final measured average temperature was 39.4. + -. 2.8 ℃. After that, the downward-falling tendency of further residual heat was measured.

Fig. 12(a) is a graph showing the temperature change of each part measured during 60 minutes using the high frequency cancer treatment apparatus of the present invention, and fig. 12(b) is a graph showing the temperature change measured during 30 minutes after the experiment.

Fig. 13 is a data table showing temperature changes of each part measured during 60 minutes by the high-frequency cancer therapy system of the present invention, and fig. 14 is a data table showing residual heat during 30 minutes after the end of the experiment.

The results based on the result values obtained in fig. 12(a) and 12(b) and fig. 13 and 14 are as follows.

The saturation frequency of the oxyhemoglobin is always kept above 99%, and the heartbeat frequency and the respiration frequency are not always out of the normal range during the experiment.

No physiological signs such as oxygen saturation, heart rate and the like are found after the experiment in the experimental period.

During the experiment it was found that 3 pigs were functioning normally. The mean baseline body temperature was 36.4. + -. 1.1 ℃ and 39.4. + -. 2.8 ℃ after 60 minutes of surgery with the present radiofrequency cancer therapy device (FIG. 13).

The body temperature of the subcutaneous fat layer (ScM) in the center of the abdomen was elevated when compared to the upper left quadrant (LUQS) near the stomach (p ═ 0.039; Mean Difference (MD), 3.86 ℃; 95% Confidence Interval (CI), 0.1864-7.5279) or the lower abdominal bladder (LAU) (p ═ 0.009; MD4.88 ℃; 95% CI, 1.2102-8.5517).

The change in body temperature of the subcutaneous fat layer (ScM) in the center of the abdomen was no difference when compared with the body temperature of the Right Upper Quadrant (RUQL) (p 0.077; MD, 3.36 ℃; 95% CI, -0.3136-7.0279) near the liver or the center of the abdomen (MA) (p 0.21; MD, 2.61; 95% CI, -1.0612-6.2803) near the small intestine.

The elevated body temperature test in the same state was observed during 60 minutes of the surgery using the high frequency cancer therapy device of the present application (fig. 12(a) and 13).

The body temperature of the first electrode part of the high-frequency cancer treatment equipment is controlled to be reduced by only 1.1 ℃ from 39.6 +/-3.13 to 38.5 +/-2.0 ℃ during 30 minutes (fig. 12(b) and 14).

Based on the experiment, the thermal treatment function results of the high-frequency cancer treatment equipment are obtained near the stomach, the liver, the small intestine and the bladder in the abdominal cavity.

Fig. 15 to 22 show temperature data measured in the inside of experimental products (pig back leg meat), bean curd, and bean jelly, which are high frequency current approvals provided by the high frequency cancer therapy apparatus of the present application, at the time of high frequency current approval, using the high frequency cancer therapy apparatus of the present application at the university of jizhou, in which the muscle of a pig similar to the muscle tissue of the body is used.

In this experimental product for pig muscle, bean curd and bean jelly had a size of 5cm x 5cm long 5cmX wide and 3cm high.

As shown in fig. 15, the measurement of the temperature change of the test article (S) according to the present invention provides measurement accuracy, and three temperature measurement units (the 1 st connector (temperature sensor, 401 in fig. 16), the 2 nd connector (temperature sensor, 402 in fig. 16), and the alcohol thermometer (403 in fig. 16)) are set in one test subject to measure the temperature after insertion in order to reduce the error of the high frequency interference measurement.

Each experimental article is placed on the second electrode part (310) of the second electrode part (300), and the 1 st electrode plate (210) of the first electrode part (200) is placed on the upper part of the experimental article.

Referring to fig. 16, the 3 temperature measuring parts (401, 402, 403) of the pork test product are inserted into different positions, and the pork test product (S1) is placed between the first electrode part (200) and the second electrode part (300) and then powered on.

As a result, as shown in FIG. 17, the temperatures of the 3 temperature measurement units exceeded 40 ℃ after 50 minutes.

As shown in fig. 18, the bean curd test product (S2) was inserted into the 3 temperature measuring parts (401, 402, 403) at different positions, and the bean curd test product (S2) was placed between the first electrode part (200) and the second electrode part (300) and then powered on.

As a result, as shown in FIG. 19, the temperatures of the 3 temperature measuring units (401, 402, 403) were close to 50 ℃ after 50 minutes.

As shown in fig. 20, the 3 temperature measuring units (401, 402, 403) of the bean jelly test article (S3) containing NaCl of 0.5% concentration were inserted at different positions, and the bean jelly test article (S3) was placed between the first electrode unit (200) and the second electrode unit (300) and then turned on.

As a result, as shown in FIG. 21, all the temperatures of the 3 temperature measurement units (401, 402, 403) were 45 ℃ or higher after 50 minutes. On the other hand, in FIG. 22, the temperature was measured when NaCl was added to the experimental agar-agar blocks at a concentration of 0%, and in this case, the temperature of 3 temperature measurement parts was 45 ℃ or higher after 50 minutes

In the above experimental results, the high frequency cancer treatment device of the present application can induce at least 40 ℃ of heat when heated for 50 minutes by high frequency current in pork, bean curd, bean jelly having similar characteristics to human body, and has the effect of killing cancer cells as described above when such temperature heat occurs in the deep part of the body.

The following is a description of the advantages of the present application, mainly in the case where the symptoms are improved after the device for treating high frequency cancer is used in real life.

[ case 1 for successful treatment ]

Treatment success case 1 treatment institution was implemented by east-west cancer center at korea hospital, tunshan, university of field.

After the patient is diagnosed with liver cancer and subjected to hepatoma resection, the patient is judged to have liver cancer relapse. The treatment with the present high-frequency treatment device was performed 2-3 times a week and about 1 time a week for about 70 times a week, for a total of 20 times.

In the case of the patient, high-frequency thermotherapy with two-way conduction was performed at 0.46MHz, and the subcutaneous temperature of the patient was measured in real time in the internal organs by a temperature measuring device at the first electrode part and the tumor surface temperature was measured as shown on the display at (39-41 ℃).

In the case of the above-mentioned patients, as seen in FIG. 23, the CT images (A, B) of the pretreatment items obtained after the high-frequency thermotherapy was performed and the CT images (C, D) after 7 times of completion of the high-frequency thermotherapy were compared to see that the change in the size of the tumor was reduced from 5.5X6cm to 3.7X4cm in the right anterior region of the liver and from 3X3.2cm to 2X2.3cm in the left inner region of the liver.

The size of the tumor reduced on CT is maintained unchanged after 18 times of high-frequency thermotherapy, and the liver cancer treatment has obvious effect.

Also accompanied with blood examination, before the start of the high-frequency thermotherapy,

blood tests were performed after 7 times of completion of the high-frequency thermotherapy and 20 times of completion of the high-frequency thermotherapy.

In fig. 24, the leftmost side is the test item, the item values tested before the second and third heat treatments, and the rightmost side is the item values tested after the completion of 20 treatments.

Blood examination results 20 times completed the activity value of NK cells (natural killer cells) rose from 468.9 to 2000 or more, and it was clearly known that the treatment according to the present application attacks NK cell activation of cancer cells to improve immune function.

[ case 2 for successful treatment ]

Treatment of patients admitted to hospital for immune hypofunction and general adverse conditions among anticancer agents for the purpose of tumor reduction before operation if the size of tumor before operation of breast cancer and lymph node metastasis of 4cm size is too large. This treatment situation is the result of being performed in the BioMed nursing hospital.

In this patient, selenase 100. mu.g of permanent 600mcg/day and seleasepro injection 2000cmg/day were taken twice weekly, and the high cycle hyperthermia treatment of this application was performed 2 times weekly (1 time 70 minutes) and zadaxin1injection twice weekly.

The result of the interferon gamma assay of NK cell activity stimulation at the beginning of treatment by this treatment was 4. 5, after 3 weeks of treatment, the value is increased to more than 2000, the immune index is increased by more than 400 times, and the breast cancer with the size of 4cm is reduced to 2cm, so that the state of the patient treated by the high-frequency hyperthermia treatment is obviously improved.

[ case 3 for successful treatment ]

The patients of this case were 60-year-old female patients with severe pain in the upper abdomen and were found to have leukopenia and immune function hospitalized in the BioMed nursing hospital after the 3-stage judgment of pancreatic cancer as 'inoperable'.

Before the patient is treated, as shown in FIG. 25, the result of the PET/CT examination shows a lump, and the condition that the peripheral blood vessels are invaded and not clearly seen is judged as the inoperable state.

The following treatment protocol was performed for the above patients in the BioMed nursing Hospital.

The selenase 100 μ g perdaral 600mcg/day and the selenase pro injection 2000cmg/day were ingested 3 times per week, after 2 times of hyperthermia treatment (1 time 70 minutes) in this application, zadaxin1injection was ingested 3 times per week. Also, lipopocin, glutathione injection was ingested 3 times per week.

The postoperative histological examination of a pancreatic cancer tumor mass determined to be 3.5cm was reduced to 0.6 cmx0.5cmx0.2cm. When the surgery was judged to be impossible, the tumor invaded into the peripheral blood vessel after the surgery, and the cancer had completely recovered from the peripheral blood vessel, and no cancer cell was found at all. The left image of the tumor appearing in the CT image of fig. 26 is largely absent from the yellow circle, and the tumor-invaded vessels are seen to return to their normal pattern.

Further, as shown in FIG. 27, the pancreatic cancer map (Tumor marker CA 19-9) was determined to have a normal value (37 or less) of 0.9, and the NK cell activity was also determined to have an out-of-normal value (500) 851.5.

In the case of the present patient, the complete removal of cancer cells was not found in the vicinity of the removed tissue even after the completion of the above treatment, and the judgment was confirmed histopathologically.

As described above, in the case of the high frequency cancer treatment apparatus of the present application, it can be understood that the temperature is increased to 40 ℃ or more at least in the deep region of the body by using the high frequency of 0.3 to 0.7MHz, and the adverse effect on normal cells is not generated by this operation, and the heat supply to cancer cells is continued and finally disappeared, as in the above treatment cases 1 to 3, the condition of the critically ill cancer patient is also improved remarkably.

The above-described embodiments should not be construed as limiting the scope of the present application, and any alternative modifications or alterations made to the embodiments of the present application will be apparent to those skilled in the art.

Those skilled in the art will appreciate that the details of the present application are not specifically described in the present application.

Claims

1. A high frequency cancer therapeutic apparatus using body resistance characteristics, comprising: the power supply part is used for obtaining and providing electric energy;

a first electrode part and a second electrode part respectively connected with the output part, wherein the first electrode part and the second electrode part are used for contacting with a body and generating current with opposite polarities;

the device also comprises a receptor detection part, a control part and a control part, wherein the receptor detection part is used for detecting the state temperature of a predetermined position of the receptor;

the state temperature is used for controlling the frequency of the high-frequency current, if the state temperature is lower than a preset temperature, the frequency of the high-frequency current is increased, and if the state temperature is higher than the preset temperature, the frequency of the high-frequency current is reduced;

and the preset position is a position which is 7-15cm away from the outer surface of the receptor by taking the outer surface of the receptor as a reference.

2. The high frequency cancer therapeutic apparatus using body resistance characteristics as set forth in claim 1, wherein: the device also comprises a control part which is respectively connected with the power supply part, the oscillation part, the regulation part and the output part in a control way.

3. The high frequency cancer therapeutic apparatus using body resistance characteristics as set forth in claim 1, wherein: the adjusting part also comprises a horizontal adjusting part which is used for adjusting the intensity of the high-frequency current.

4. The high frequency cancer therapeutic apparatus using body resistance according to claim 2, wherein: the adjusting part also comprises a horizontal adjusting part, the horizontal adjusting part is used for adjusting the intensity of the high-frequency current, and the horizontal adjusting part is connected with the controller.

5. The high frequency cancer therapeutic apparatus using body resistance characteristics as set forth in claim 1, wherein: the high-frequency current is 0.3MHz-0.7MHz current.

6. The high frequency cancer therapeutic apparatus using body resistance characteristics as set forth in claim 1, wherein: the high-frequency current is 0.46MHz current.

7. The high frequency cancer therapeutic apparatus using body resistance characteristics as set forth in claim 1, wherein: the predetermined temperature is 40 ℃.