CN109430253A - A kind of Perfused isolated heart system that binary channels holocentric is dirty - Google Patents
A kind of Perfused isolated heart system that binary channels holocentric is dirty Download PDFInfo
- Publication number
- CN109430253A CN109430253A CN201910015974.XA CN201910015974A CN109430253A CN 109430253 A CN109430253 A CN 109430253A CN 201910015974 A CN201910015974 A CN 201910015974A CN 109430253 A CN109430253 A CN 109430253A
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- Prior art keywords
- installation base
- base plate
- holocentric
- snakelike
- heat insulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000009434 installation Methods 0.000 claims abstract description 34
- 238000009413 insulation Methods 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 239000007921 spray Substances 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000004321 preservation Methods 0.000 claims description 22
- 230000002459 sustained effect Effects 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 claims description 3
- 230000010412 perfusion Effects 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 7
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 241001468684 Diplocardia Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Devices For Medical Bathing And Washing (AREA)
Abstract
The present invention relates to Perfused isolated heart fields, specifically, it is related to a kind of Perfused isolated heart system that binary channels holocentric is dirty, including installation base plate, heat insulation tank, bathe chamber, flesh component, syringe needle, two overflow cups and two snakelike heaters, two overflow cups, two snakelike heaters, heat insulation tank and bath chamber are arranged in order at the side of installation base plate from top to down along the vertical direction, the outside of bath chamber is arranged in flesh component, the lower section of flesh component is arranged in syringe needle, Rule threeway is equipped at the top of the bottom of each snakelike heater and heat insulation tank, the back side of installation base plate is equipped with liquid storage bottle, each overflow cup passes through a spray pump and is connected to liquid storage bottle, a kind of Perfused isolated heart system that binary channels holocentric is dirty disclosed by the invention, the difference for solving individuality causes the uncertainty of data and the comparativity of data, simultaneously Participate in the perfusion system and only need a heart, and replace reach after drug heart time it is predictable.
Description
Technical field
The present invention relates to Perfused isolated heart fields, and in particular, to a kind of Perfused isolated heart that binary channels holocentric is dirty
System.
Background technique
Perfused isolated heart device is a set of important composition of Perfused isolated heart, and medicine is perfused by peristaltic pump in isolated heart
Liquid measures the parameters such as its heart rate and tension, eliminates the interference of nerve and hormone in vivo.Software is cooperated to analyze its each seed ginseng again
Number index.Physiology and pathology research to being widely applied.
It a, is at present on the market mainly a kind of single pass Perfused isolated heart device either dirty filling of binary channels diplocardia
Stream.Single pass cardiac perfusion device has biggish limitation in terms of the research of physiology and pathology, and the comparison of data becomes tired
Difficulty, and cannot determine when that medical fluid reaches heart in midway replacement medical fluid.
B, binary channels diplocardia is dirty while equally existing difficulty in terms of the comparison of data, because being 2 hearts, heart itself
It is exactly a variable during experiment, so data have very big uncertainty.The binary channels diplocardia is dirty in perfusion simultaneously
2 hearts must be obtained in the process, and cost undoubtedly improves for experiment.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of Perfused isolated heart system that binary channels holocentric is dirty.
A kind of Perfused isolated heart system that binary channels holocentric is dirty disclosed by the invention, including installation base plate, heat insulation tank, bath
Chamber, flesh component, syringe needle, two overflow cups and two snakelike heaters, installation base plate, bath chamber, heat insulation tank and two it is snakelike plus
The state setting in a vertical shape of hot device, two snakelike heaters are in sustained height setting, and two overflow cups are set in sustained height
It sets, two overflow cups, two snakelike heaters, heat insulation tank and bath chamber are arranged in order at installation from top to down along the vertical direction
The outside of bath chamber is arranged in the side of substrate, flesh component, and the lower section of flesh component is arranged in syringe needle, each snakelike heater
Rule threeway is equipped at the top of bottom and heat insulation tank, the back side of installation base plate is equipped with liquid storage bottle, and each overflow cup is logical
It crosses a spray pump and is connected to liquid storage bottle, the lower section of heat insulation tank is arranged in bath chamber.
Preferably, the bottom of installation base plate is fixedly connected with a horizontally disposed bottom plate, and the back side of installation base plate is symmetrically set
There are two strut, the upper and lower side of strut is fixedly connected with installation base plate and bottom plate respectively.
Preferably, installation base plate is equipped with graduation mark along the vertical direction, the upper half of installation base plate and lower half difference
The bar shaped adjustment hole for overflow cup and bath intonation section height is used for equipped with several.
Preferably, overflow cup is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet and medical fluid overflow port for being equipped with medical fluid,
Outer layer is heat preservation water layer and is equipped with heat preservation water entrance.
Preferably, snakelike heater is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is to protect
Warm water layer and be equipped with heat preservation water entrance, snakelike heater body medical fluid layer be equipped with helix tube.
Preferably, heat insulation tank is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is heat preservation water
Layer and it is equipped with heat preservation water entrance, spiral helicine glass tube is equipped with inside heat insulation tank.
Preferably, bath chamber is the hollow form structure of open upper end, and is equipped with the inlet and outlet of heat preservation water.
The utility model has the advantages that a kind of Perfused isolated heart system that binary channels holocentric is dirty disclosed by the invention, solves individuality
Difference cause the uncertainty of data and the comparativity of data, simultaneously participate in the perfusion system and only need a heart, and
The time that heart is reached after replacement drug is predictable.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present application, constitutes part of this application, this Shen
Illustrative embodiments and their description please are not constituted an undue limitation on the present application for explaining the application.In the accompanying drawings:
Fig. 1 is schematic perspective view of the invention；
Fig. 2 is pipeline connecting figure of the invention；
Fig. 3 is the structure chart of first liquid storage bottle；
Fig. 4 is the structure chart of second liquid storage bottle；
Description of symbols: 1- overflow cup, 2- installation base plate, 3- strut, the snakelike heater of 4-, 5- heat insulation tank, 6- bathe chamber, 7- flesh
Open component, 8- bottom plate, 9- bar shaped adjustment hole.
Specific embodiment
Multiple embodiments of the invention will be disclosed with schema below, as clearly stated, the details in many practices
It will be explained in the following description.It should be appreciated, however, that the details in these practices is not applied to limit the present invention.Also
It is to say, in some embodiments of the invention, the details in these practices is non-essential.In addition, for the sake of simplifying schema,
Some known usual structures and component will be painted it in the drawings in simply illustrative mode.
In addition, the description for being such as related to " first ", " second " in the present invention is used for description purposes only, not especially censure
The meaning of order or cis-position, also non-to limit the present invention, the component described just for the sake of difference with same technique term
Or operation, it is not understood to indicate or imply its relative importance or implicitly indicates the number of indicated technical characteristic
Amount." first " is defined as a result, the feature of " second " can explicitly or implicitly include at least one of the features.In addition, each
Technical solution between a embodiment can be combined with each other, but must can be implemented as base with those of ordinary skill in the art
Plinth will be understood that the combination of this technical solution is not present when conflicting or cannot achieve when occurs in the combination of technical solution,
Also not the present invention claims protection scope within.
A kind of Perfused isolated heart system that binary channels holocentric is dirty referring to figs. 1 to 4, including installation base plate 2, guarantor
Warm tank 5, bath chamber 6, flesh component 7, syringe needle, two overflow cups 1 and two snakelike heaters 4, installation base plate 2, bath chamber 6, heat preservation
Tank 5 and the state setting in a vertical shape of two snakelike heaters 4, two snakelike heaters 4 are in sustained height setting, two overflows
Cup 1 is arranged in sustained height, and two overflow cups, 1, two snakelike heater 4, heat insulation tank 5 and bath chamber 6 are along the vertical direction from upper
The side of installation base plate 2 is arranged in order under and, the outside of bath chamber 6 is arranged in flesh component 7, and syringe needle setting is in flesh group
The lower section of part 7, the bottom of each snakelike heater 4 and the top of heat insulation tank 5 are equipped with Rule threeway, installation base plate 2
Back side is equipped with liquid storage bottle, and each overflow cup 1 is connected to liquid storage bottle by a spray pump, and bath chamber 6 is arranged under heat insulation tank 5
Side.
The bottom of installation base plate 2 is fixedly connected with a horizontally disposed bottom plate 8, and the back side of installation base plate 2 is symmetrically arranged with two
A strut 3, the upper and lower side of strut 3 are fixedly connected with installation base plate 2 and bottom plate 8 respectively.Bottom plate 8 uses 6061 materials, does sandblasting
Sky blue anodized.
Installation base plate 2 is equipped with graduation mark along the vertical direction, if the upper half and lower half of installation base plate 2 are respectively equipped with
Dry for adjusting the bar shaped adjustment hole 9 of height for overflow cup 1 and bath chamber 6.Installation base plate 2 is PMMA material, is other each portions
The mounting platform of part, and scale is indicated, facilitate accurate positionin height.
Overflow cup 1 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, and inlet and outlet and medical fluid equipped with medical fluid are overflow
Head piece, outer layer are heat preservation water layer equipped with heat preservation water entrance, the adjustable height on substrate, adjustable range 0-200mm,
Outside dimension φ 50 × 120, inside dimension are φ 30 × 60.
Snakelike heater 4 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, the inlet and outlet equipped with medical fluid, outer layer
It is equipped with heat preservation water entrance for heat preservation water layer, for persistently carrying out the pre-heat treatment to perfusate, internal medical fluid layer uses helix tube,
Bore is 3-4mm, and spiral number of turns are 8 circles, screw pitch 12mm.
Heat insulation tank 5 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, and the inlet and outlet equipped with medical fluid, outer layer is to protect
Warm water layer is equipped with heat preservation water entrance, and inside is spiral helicine glass tube, which is medical fluid pipeline, and glass bore is 3-4mm,
Principal security medical fluid flows through road length as far as possible wherein and medical fluid is relatively next small in size, to reach exposure in not used branch
Effect after being preheated again after being partially cooled to room temperature in air.
The hollow form structure that chamber 6 is open upper end is bathed, and is equipped with the inlet and outlet of heat preservation water.It bathes chamber 6 and uses GG17 material
Heart is placed in during experiment by mobile bath chamber 6 by material, open upper end hollow form, the inlet and outlet equipped with heat preservation water
Wherein, to reach heat insulation effect.
Working principle:
It is the road (left side) and the road (right side) of the second perfusion of the first perfusion that two liquid storage bottles are corresponding.
Process is perfused: the A1 in the outlet map interlinking of the outlet A6 spray pump of the entrance access liquid storage bottle memory of spray pump leads to
Medical fluid is passed through the overflow port D1 pipeline of overflow cup 1 by the pressure for crossing pump by the medical fluid that it is extra that A2 squeezes into left side 1 internal layer of overflow cup
It returns in liquid storage bottle, the internal layer of snakelike heater 4 is flowed by A4, II-F1- of Rule threeway, I-F3 is finally flowed into heat insulation tank 5
Enter onto the syringe needle for hanging with heart；Similarly the road filling process on right side is the same.Rule threeway I must only during perfusion
Guarantee smooth the way or all block, two-way cannot be penetrated through, otherwise liquid medicine contamination.
Keep the temperature process: the entire circuit of heat preservation is a concatenated loop checking installation.
The C10 mouth of the outlet access liquid storage bottle of water bath with thermostatic control connects liquid storage bottle and liquid storage bottle by C11, and C12 pipeline connects
The outer layer water access port for connecing bath 6 lower end of chamber flows into heat insulation tank 5 and then is divided into two-way by threeway flows into left and right side respectively
The outer layer of snakelike heater 4, subsequently into respective overflow cup 1；Water kept the temperature by threeway converged return water bath with thermostatic control,
Whole process is a closed loop checking installation.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (7)
1. a kind of Perfused isolated heart system that binary channels holocentric is dirty, it is characterised in that: including installation base plate (2), heat insulation tank
(5), chamber (6), flesh component (7), syringe needle, two overflow cups (1) and two snakelike heaters (4), installation base plate (2), bath are bathed
The state setting in a vertical shape of chamber (6), heat insulation tank (5) and two snakelike heaters (4), two snakelike heaters (4) are in same
Height is arranged, and two overflow cups (1) are in sustained height setting, two overflow cups (1), two snakelike heaters (4), heat insulation tanks
(5) and the side that chamber (6) are arranged in order at installation base plate (2) from top to down along the vertical direction is bathed, flesh component (7) is arranged
In the outside of bath chamber (6), syringe needle setting is in the lower section of flesh component (7), the bottom of each snakelike heater (4) and heat insulation tank
(5) Rule threeway is equipped at the top of, the back side of installation base plate (2) is equipped with liquid storage bottle, and each overflow cup (1) passes through one
A spray pump is connected to liquid storage bottle, lower section of bath chamber (6) setting in heat insulation tank (5).
2. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: installation base
The bottom of plate (2) is fixedly connected with a horizontally disposed bottom plate (8), and the back side of installation base plate (2) is symmetrically arranged with two struts
(3), the upper and lower side of strut (3) is fixedly connected with installation base plate (2) and bottom plate (8) respectively.
3. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: installation base
Plate (2) is equipped with graduation mark along the vertical direction, and the upper half and lower half of installation base plate (2) are respectively equipped with several for supplying
Overflow cup (1) and bath chamber (6) adjust the bar shaped adjustment hole (9) of height.
4. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: overflow cup
(1) be divided into ectonexine, internal layer is medical fluid layer and the inlet and outlet and medical fluid overflow port for being equipped with medical fluid, outer layer be heat preservation water layer and
Equipped with heat preservation water entrance.
5. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: snakelike to add
Hot device (4) is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is heat preservation water layer and is equipped with heat preservation
Water entrance, the internal medical fluid layer of snakelike heater (4) are equipped with helix tube.
6. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: heat insulation tank
(5) it is divided into ectonexine, internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is heat preservation water layer and goes out equipped with heat preservation water
Entrance, heat insulation tank (5) is internal to be equipped with spiral helicine glass tube.
7. a kind of Perfused isolated heart system that binary channels holocentric is dirty according to claim 1, it is characterised in that: bath chamber
(6) it is the hollow form structure of open upper end, and is equipped with the inlet and outlet of heat preservation water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910015974.XA CN109430253A (en) | 2019-01-08 | 2019-01-08 | A kind of Perfused isolated heart system that binary channels holocentric is dirty |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910015974.XA CN109430253A (en) | 2019-01-08 | 2019-01-08 | A kind of Perfused isolated heart system that binary channels holocentric is dirty |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109430253A true CN109430253A (en) | 2019-03-08 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910015974.XA Pending CN109430253A (en) | 2019-01-08 | 2019-01-08 | A kind of Perfused isolated heart system that binary channels holocentric is dirty |
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| Country | Link |
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| CN (1) | CN109430253A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112616827A (en) * | 2020-11-30 | 2021-04-09 | 中国科学技术大学 | Erythrocyte cryopreservation method and cryopreserved erythrocytes |
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| US20050147958A1 (en) * | 1997-09-23 | 2005-07-07 | Waleed Hassanein | Compositions, method and devices for maintaining an organ |
| CN201993969U (en) * | 2010-07-09 | 2011-09-28 | 云南中医学院 | Constant-pressure and constant-temperature perfusion device |
| CN202421174U (en) * | 2012-01-30 | 2012-09-05 | 徐州医学院 | Isolated heart perfusion device |
| CN102812117A (en) * | 2010-01-29 | 2012-12-05 | 株式会社器官再生工学 | Perfusion culture method and perfusion culture device for organ or tissue |
| CN103750905A (en) * | 2014-01-20 | 2014-04-30 | 辽宁中医药大学 | Isolated working heart dual-channel perfusion experiment method and device for large animals |
| JP2014100643A (en) * | 2012-11-19 | 2014-06-05 | Uerushii:Kk | Reservoir feeding device and method of medicinal solution, and ground water clarification processor and method |
| US20140217027A1 (en) * | 2013-02-01 | 2014-08-07 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
| CN107156109A (en) * | 2017-05-31 | 2017-09-15 | 上海市杨浦区市东医院 | A kind of isolated organ preserves system |
| CN108535463A (en) * | 2018-05-07 | 2018-09-14 | 厦门大学附属第医院 | Perfused isolated heart experimental provision and Perfused isolated heart experimental method |
-
2019
- 2019-01-08 CN CN201910015974.XA patent/CN109430253A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050147958A1 (en) * | 1997-09-23 | 2005-07-07 | Waleed Hassanein | Compositions, method and devices for maintaining an organ |
| CN102812117A (en) * | 2010-01-29 | 2012-12-05 | 株式会社器官再生工学 | Perfusion culture method and perfusion culture device for organ or tissue |
| CN201993969U (en) * | 2010-07-09 | 2011-09-28 | 云南中医学院 | Constant-pressure and constant-temperature perfusion device |
| CN202421174U (en) * | 2012-01-30 | 2012-09-05 | 徐州医学院 | Isolated heart perfusion device |
| JP2014100643A (en) * | 2012-11-19 | 2014-06-05 | Uerushii:Kk | Reservoir feeding device and method of medicinal solution, and ground water clarification processor and method |
| US20140217027A1 (en) * | 2013-02-01 | 2014-08-07 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112616827A (en) * | 2020-11-30 | 2021-04-09 | 中国科学技术大学 | Erythrocyte cryopreservation method and cryopreserved erythrocytes |
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Application publication date: 20190308 |