CN109430076A - A kind of device forcing receptor sleep fragmentation - Google Patents
A kind of device forcing receptor sleep fragmentation Download PDFInfo
- Publication number
- CN109430076A CN109430076A CN201811539552.4A CN201811539552A CN109430076A CN 109430076 A CN109430076 A CN 109430076A CN 201811539552 A CN201811539552 A CN 201811539552A CN 109430076 A CN109430076 A CN 109430076A
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- China
- Prior art keywords
- receptor
- sleep
- transmission
- hairbrush
- conveyer belt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000010340 Sleep Deprivation Diseases 0.000 title claims abstract description 28
- 230000005540 biological transmission Effects 0.000 claims abstract description 57
- 230000007246 mechanism Effects 0.000 claims abstract description 23
- 230000007958 sleep Effects 0.000 abstract description 27
- 238000000034 method Methods 0.000 abstract description 11
- 210000000078 claw Anatomy 0.000 abstract description 5
- 238000013461 design Methods 0.000 abstract description 5
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000000392 somatic effect Effects 0.000 abstract description 2
- 241000700159 Rattus Species 0.000 description 23
- 230000033001 locomotion Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000013467 fragmentation Methods 0.000 description 6
- 238000006062 fragmentation reaction Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 238000010171 animal model Methods 0.000 description 3
- 230000005059 dormancy Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000008784 apnea Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000001797 obstructive sleep apnea Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 238000010408 sweeping Methods 0.000 description 2
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 206010059138 Glossoptosis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000036385 rapid eye movement (rem) sleep Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K3/00—Pasturing equipment, e.g. tethering devices; Grids for preventing cattle from straying; Electrified wire fencing
Abstract
The present invention provides a kind of devices for forcing receptor sleep fragmentation, including the transmission mechanism that receptor case, receptor bottom end are arranged, wherein；The transmission mechanism includes at least two transmission shafts, rolls the transmission belt for connecting setting with the transmission shaft, wherein；At least provided with a set of hairbrush on the transmission belt, the present invention provides a kind of devices for forcing receptor sleep fragmentation, its frequency and duration that conveyer belt operating is adjusted by the setting of host computer procedure, allow hairbrush on conveyer belt, timing is swept and receptor four limbs and when claw, receptor foot bottom is uncomfortable and is forced to stand up across hairbrush, it regularly interferes by somatic sleep by this method, finally force receptor sleep fragmentation, present invention design is simple, modeling efficiency is few, powerful, easy to operate compared with high, noiseless stimulation, stressor, has high commercial value.
Description
Technical field
The present invention relates to field of medical technology, especially a kind of device for forcing receptor sleep fragmentation.
Background technique
Sleep is one of instinctive behavior of living organism, has important meaning with individual survival for maintaining race to continue
Justice, in addition, sleep is also very unique forms of motion in a kind of life, be body conducted in vital movement it is a kind of from
I is adjusted and the process of self-protection, the maintenance of normal physiological and psychological aspects for body have very crucial work
With.
In the development process of modern society, the circadian rhythm of the mankind is also constantly being accelerated, and various negative emotions are also therewith
, while many stress events can be encountered in life, or even can therefore generate a series of sleep disturbance or generate and sleep
It sleeps the situation deprived, to influence each system physiological function of body, causes sleeping disorders, and obstructive sleep apnea low pass
Gas syndrome be exactly it is one such, obstruction sleep apnea-hypopnea syndrome is due to epithelium healing flesh during sleep
Disease caused by epithelium healing caused by power decline and glossoptosis is narrow, can bring negative when disease pathology disorder to patient
Society, economic impact, pathologic, physiologic feature first is that sleep fragmentation, that is, the awakening frequently occurred (or wake-up) causes to sleep
Continuity be destroyed or interrupt, occur many short time segment sleep.And sleep fragmentation is likely to result in apparent day
Between it is drowsiness, and cause the decline of cognitive function, therefore we need to further investigate sleep disordered breathing class disease, production animal sleeps
Dormancy fragmentation model is exactly one such method, it can explore neurotrosis and disease caused by sleep disordered breathing class disease
Manage physiological mechanism.
Foreign scholar Phillipson etc. once proposes a kind of animal sleep fragmentation model to this, by using noise
Stimulation, but long-term the tinkle of bells stimulates the disadvantages of bringing habituation, is gradually no longer applied；In addition it is other several researchers have proposed
A kind of model using photoelectricity Induced by Stimulation sleep fragmentation, but disturbed in experimentation since stress reaction occurs in animal
Subsequent experimental result；In addition, someone deprives rat mould using vase technology (flower pot technique) production REM sleep
Type, i.e. rat platform it is enterprising enter sleep after it is loose with whole-body muscle and rhythmicity is hung one's head, rat falls into the water and wakes up with a start, then
It is secondary to climb up platform.The model is more demanding to water temperature and ambient temperature, is not easy the frequency of control sleep fragmentation, that is, awakens
Index, and the animal water that is easy to choke leads to pneumonia.Recently, full sleep deprivation or partial sleep that McGinty, Strecker etc. are used
The model deprived utilizes this stimulus modality of treadmill of " relative motion " to prevent experimental animal from persistently remaining stationary state,
And then sleep procedure is interfered, but device design is relatively complicated, and can only carry out modeling to an animal every time, efficiency compared with
It is low.
Therefore, clinically there is no a kind of being able to solve above-mentioned technical problem, a kind of to design simply, modeling efficiency at present
High, noiseless stimulation, stressor are few, cause the device of experimental animal sleep fragmentation, specifically, there is no one kind to force receptor
The device of sleep fragmentation.
Summary of the invention
For technological deficiency of the existing technology, the object of the present invention is to provide a kind of receptor sleep fragmentations that forces
Device, including the transmission mechanism that receptor case, receptor bottom end are arranged, wherein；The transmission mechanism include at least two transmission shafts,
The transmission belt of connection setting is rolled with the transmission shaft, wherein；
At least provided with a set of hairbrush on the transmission belt.
It preferably, further include a driving device, the driving device is electrically connected the transmission mechanism.
It preferably, further include a host computer, the host computer connects the transmission mechanism.
It preferably, further include a skylight, the top of the receptor case is arranged in the skylight.
Preferably, the frequency of the conveyer belt operating is 0.5min/ times~2min/ times.
Preferably, the duration of the conveyer belt operating is 10s~100s.
Preferably, the height of the hairbrush and the limbs height of the receptor are adapted.
Preferably, the receptor case at least accommodates four receptors.
Preferably, the receptor is rat.
The present invention provides a kind of devices for forcing receptor sleep fragmentation periodically to be swept by the hairbrush on conveyer belt
And when receptor four limbs and claw, receptor foot bottom is uncomfortable and is forced to stand up across hairbrush, and regularly interference rat sleeps by this method
It sleeps, finally forces receptor sleep fragmentation, it is the configuration of the present invention is simple, powerful, easy to operate, there is high business valence
Value.
Detailed description of the invention
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other feature of the invention,
Objects and advantages will become more apparent upon:
Fig. 1 shows a specific embodiment of the invention, a kind of schematic diagram for the device forcing receptor sleep fragmentation.
Specific embodiment
In order to preferably technical solution of the present invention be made clearly to show, the present invention is made into one with reference to the accompanying drawing
Walk explanation.
Fig. 1 shows a specific embodiment of the invention, a kind of schematic diagram for the device forcing receptor sleep fragmentation,
Specifically, the object of the present invention is to provide a kind of devices for forcing receptor sleep fragmentation, including receptor case, receptor bottom end to set
The transmission mechanism set, as shown in Figure 1, can place more receptors in the receptor case, the receptor is slept in receptor case
The experiment of dormancy fragmentation, the bottom in the receptor case are provided with transmission mechanism, and the transmission mechanism is carried on the back attached hairbrush, can be rolled
Hairbrush is transmitted, Sleep in Rats is then regularly interfered.
Further, the transmission mechanism includes at least two transmission shafts, rolls the biography for connecting setting with the transmission shaft
Dynamic band, the transmission mechanism are composed by transmission shaft and with the transmission belt of transmission axis connection, and the effect of the transmission mechanism is
By transmission shaft, transmission belt is rotated, enables the swiped through receptor four limbs of hairbrush, make receptor sleep fragmentation, as shown in Figure 1, institute
State two direction of left and right that two transmission shafts are located among transmission belt, described two transmission axis connection conveyer belts, the transmission
Axis drives the conveyer belt to be moved.
At least provided with a set of hairbrush on the transmission belt, it will be appreciated by those skilled in the art that described two transmission shafts drive
The conveyer belt is moved, and has hairbrush on the conveyer belt, enables hairbrush with certain swiped through receptor four limbs of frequency, tool
Body, after transfer structure enters working condition, the receptor is placed into receptor case, two transmission shafts in the receptor case
It starts turning, and the conveyer belt is driven to be moved, hairbrush is had on the conveyer belt, conveyer belt is when being moved, meeting
Prolong clockwise push inswept cage bottom, hairbrush can also be moved with conveyer belt, and the four limbs of inswept receptor, receptor sleep when by
To interference, to make receptor sleep fragmentation.
In a preferred embodiment, after receptor case is initially powered up, the conveyer belt for carrying on the back attached hairbrush is placed in cage bottom,
And by PC control, start under the fixed frequency preset, and prolongs in cage bottom and push inswept cage clockwise
Bottom rolls hairbrush by preset frequency and then regularly interferes Sleep in Rats, and analog sleeping takes place frequently in apnea patient night
Microarousal event and cause Sleep in Rats fragmentation.
It further, further include a driving device, the driving device is electrically connected the transmission mechanism, those skilled in the art
Member understands, as shown in Figure 1, the driving device connects the transmission mechanism, the transmission mechanism includes two transmission shafts and biography
Band is sent, the driving device connects two transmission shafts and conveyer belt, and the effect of the driving device is to turn amplified instruction
Becoming mechanical movement, drives movable workbench using mechanical transmissioning piece, it is the power section of entire receptor case, specifically,
Driving device, which will drive two transmission shafts, after receptor case is powered, in the course of work causes conveyer belt to carry out intermittent movement.
It further, further include a host computer, the host computer connects the transmission mechanism, as shown in Figure 1, described upper
Machine is located at outside receptor case, and connects receptor case, is used to control the frequency of transmission tape starting and rotates duration and speed, and is pre-
If sending the frequency with operating and duration etc., the sleep fragmentation mode of a variety of different severity can be realized.
Further, further include a skylight, the top of the receptor case is arranged in the skylight, can be put into receptor case by
Body, the receptor are needed to breathe and could be survived, and therefore, are provided with skylight above receptor case, and its purpose is to allow receptor
It can be survived in receptor case internal respiration.
Further, the frequency of the conveyer belt operating is 0.5min/ times~2min/ times, it will be appreciated by those skilled in the art that
The operating frequency of the conveyer belt is controlled by host computer, is fixed on the operating frequency of conveyer belt 2 minutes in host computer
Once, every time 30 seconds, that is, a variety of different sleep fragmentation modes are realized, the conveyer belt for carrying on the back attached hairbrush is placed in cage bottom, can
By PC control, starting and prolongs in cage bottom under a certain fixed frequency and push inswept cage bottom, Zhou Erfu clockwise
Begin.
In a preferred embodiment, the operating frequency that experimenter sets conveyer belt on host computer is one minute
Once, each duration is 20 seconds, and after receiving the pre-set commands of host computer, driving device drives the biography in transmission mechanism
Moving axis and transmission belt are moved, and the hairbrush for being attached to transmission shaft back starts running, with the four limbs of the inswept receptor of fixed frequency,
It is interfered by somatic sleep, microarousal event is in the night of quasi- sleep apnea patient to cause sleep fragmentation.
The duration of the conveyer belt operating is 10s~100s, it will be appreciated by those skilled in the art that carrying on the back the transmission of attached hairbrush
Band is placed in cage bottom, can be by PC control along push clockwise, and the time of host computer persistent movement is 10 seconds to 100 seconds
Between, that is, it realizes a variety of different sleep fragmentation modes, carries on the back the conveyer belt fixed response time of attached hairbrush rotationally clockwise, when sweeping
And when rat claw and four limbs, rat is passively stood up across hairbrush, in cycles.
Further, the height of the hairbrush and the limbs height of the receptor are adapted, it will be appreciated by those skilled in the art that
The height of hairbrush will be in same level with the limbs height of the receptor, can guarantee that the receptor is carried out in conveyer belt in this way
Hairbrush just swiped through receptor four limbs when transmission.
Further, the receptor case at least accommodates four receptors, and four receptors can be accommodated in the receptor case and are slept
The experiment of dormancy fragmentation, by the control of host computer, conveyer belt (such as 2 minutes primary, 30 seconds every time) under a certain fixed frequency is opened
It moves and prolongs in cage bottom and push inswept cage bottom clockwise.
Further, the receptor can be two, select two rats to close in receptor case as receptor, in host computer
The frequency of upper setting conveyer belt and when a length of 90 seconds it is primary, the time of each conveyer belt operation continued in 30 seconds, set frequency
After rate, driving device initially enters working condition and transmission mechanism is driven to be moved, and hairbrush is attached to the back of transmission mechanism,
And as conveyer belt timing is along rotationally clockwise, when the swiped through rat four limbs of the hairbrush on conveyer belt and claw, rat
Foot bottom is uncomfortable and is forced to stand up across hairbrush, and in cycles, 90 seconds are primary, regularly interferes Sleep in Rats by this method, from
And cause Sleep in Rats fragmentation.
In existing some models, the model that full sleep deprivation or partial sleep are deprived utilizes the race of " relative motion " mostly
This stimulus modality of step machine prevents experimental animal from persistently remaining stationary state, and then sleep procedure is interfered, this sleep
Model not only designs complexity, and can only accommodate a receptor in a receptor case and carry out modeling, and modeling efficiency is lower, the design
In can accommodate four receptors in a receptor case and carry out modelings, working efficiency significantly improves.
Further, the receptor is rat, it will be appreciated by those skilled in the art that carrying out modeling with more excellent using rat
Point, experiment need statistical analysis, and this requires certain quantity, big white mouse is able to satisfy this and wants under the conditions of artificial propagation
It asks, and the biological significance for testing Special rat is larger, the mouse cultivated is inborn a almost complete absence of individual difference
Body difference can be reduced, therefore it is reasonable for selecting rat as receptor.
In a preferred embodiment, when experimenter presets operating frequency and the operating of conveyer belt in host computer
Long, operating frequency is one minute primary, and operating duration continues 30 seconds, and three rats are put into receptor case, is attached to biography
It send the hairbrush of back belt to move with fixed frequency and prolongs and push inswept cage bottom clockwise, when sweeping and rat claw and when four limbs,
Sleep in Rats interrupts, and passively stands up across hairbrush, in cycles, thus micro- feel that analog sleeping takes place frequently in apnea patient night
Wake up event and cause Sleep in Rats fragmentation.
Specific embodiments of the present invention are described above, it is to be understood that the invention is not limited to above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, but this not shadow
Substantive content of the invention is rung, it will not be described here.
Claims (9)
1. a kind of device for forcing receptor sleep fragmentation, which is characterized in that be arranged including receptor case (1), receptor bottom end
Transmission mechanism (2), wherein；
The transmission mechanism includes at least two transmission shafts (21), rolls the transmission belt (22) for connecting setting with the transmission shaft,
Wherein；
At least provided with a set of hairbrush (3) on the transmission belt.
2. the apparatus according to claim 1, which is characterized in that it further include a driving device, the driving device electrical connection
The transmission mechanism.
3. the apparatus according to claim 1, which is characterized in that further include a host computer (4), described in the host computer connection
Transmission mechanism.
4. the apparatus according to claim 1, which is characterized in that further include a skylight (5), skylight setting it is described by
The top of body case.
5. the apparatus according to claim 1, which is characterized in that the frequency of conveyer belt operating is 0.5min/ times~
2min/ times.
6. the apparatus according to claim 1, which is characterized in that the duration of the conveyer belt operating is 10s~100s.
7. the apparatus according to claim 1, which is characterized in that the limbs height phase of the height of the hairbrush and the receptor
It adapts to.
8. the apparatus according to claim 1, which is characterized in that the receptor case at least accommodates four receptors.
9. the apparatus according to claim 1, which is characterized in that the receptor is rat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811539552.4A CN109430076A (en) | 2018-12-17 | 2018-12-17 | A kind of device forcing receptor sleep fragmentation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811539552.4A CN109430076A (en) | 2018-12-17 | 2018-12-17 | A kind of device forcing receptor sleep fragmentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109430076A true CN109430076A (en) | 2019-03-08 |
Family
ID=65559788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811539552.4A Pending CN109430076A (en) | 2018-12-17 | 2018-12-17 | A kind of device forcing receptor sleep fragmentation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109430076A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111742847A (en) * | 2020-07-15 | 2020-10-09 | 华中科技大学同济医学院附属同济医院 | Built-in animal sleep deprivation device |
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2018
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