CN109393195B - Choline chloride feed additive and preparation method thereof - Google Patents
Choline chloride feed additive and preparation method thereof Download PDFInfo
- Publication number
- CN109393195B CN109393195B CN201811382203.6A CN201811382203A CN109393195B CN 109393195 B CN109393195 B CN 109393195B CN 201811382203 A CN201811382203 A CN 201811382203A CN 109393195 B CN109393195 B CN 109393195B
- Authority
- CN
- China
- Prior art keywords
- choline chloride
- feed additive
- parts
- chitosan
- chloride feed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention belongs to the field of feed additives, and particularly relates to a choline chloride feed additive and a preparation method thereof. The choline chloride feed additive comprises, by weight, 50-70 parts of choline chloride, 1-3 parts of chitosan and 10-15 parts of bean dreg powder. The choline chloride feed additive has good antibacterial property, is not easy to oxidize and disperse when meeting water, does not absorb moisture, agglomerate or ferment, is not easy to deteriorate, improves the storage effect of the feed, effectively prolongs the storage time of the choline chloride feed additive, has good taste, no toxic or side effect and comprehensive and balanced nutritional ingredients, not only provides double nutritional effects of trace elements and amino groups for animals, but also effectively improves the immunity and anti-stress capability of the animals, prevents diseases, prevents constipation of the animals and further improves the reproductive performance of the animals; the invention has no chemical antioxidant, no toxic side effect and is suitable for long-term use.
Description
Technical Field
The invention belongs to the field of feed additives, and particularly relates to a choline chloride feed additive and a preparation method thereof.
Background
The growth and development of the poultry and the livestock need certain microelements and vitamins, so that the poultry and the livestock are developed robustly and the growth and reproductive capacity of the poultry and the livestock are accelerated. Choline (2-hydroxyethyl-trimethylcholine hydroxide) is one of the vitamin B. It has strong basicity, choline chloride (C)5H14NCLO) is choline chloride, the aqueous solution being weakly acidic. The functional action of choline in metabolism and growth of livestock and poultry is mainly shown in that (1) choline is converted into betaine, methyl is provided to combine with homocysteine to form methionine, and the cost of feed is reduced; (2) as an important component of lecithin, the lecithin plays an important role in preventing the poultry shin bone rough disease and the pig limb external spread disease; (3) preventing fatty liver by promoting fat transport in the form of lecithin or by preventing abnormal accumulation of fat by increasing liver's utilization of fatty acids; (4) and is involved in nerve conduction. Choline is a precursor of the neurotransmitter acetylcholine, an important constituent of sphingomyelin. The choline chloride has obvious effects of promoting the growth and development of livestock and poultry, improving the quality of meat and eggs, preventing and resisting diseases and reducing the cost of feed, and is an indispensable vitamin feed additive.
At present, most manufacturers take bran, corncob or rice chaff and the like as carriers, and dilute choline chloride into 50% powder for use in feed production. On one hand, the produced 50% choline chloride feed additive is easy to oxidize, and the condition of moisture absorption and caking or paste formation can occur after being exposed for 30 min. Therefore, the feed additive has short storage period and easy deterioration, resulting in poor palatability and low nutritional ingredients.
Disclosure of Invention
The invention aims to overcome the defect that a choline chloride feed additive in the feed for laying ducks in the prior art is easy to oxidize, and provides the choline chloride feed additive and the preparation method thereof.
A choline chloride feed additive comprises, by weight, 50-70 parts of choline chloride, 1-3 parts of chitosan and 10-15 parts of bean dreg powder.
Preferably, the feed comprises 60 parts of choline chloride, 2 parts of chitosan and 13 parts of bean dregs powder by weight.
Preferably, the chitosan is a chlorinated chitosan.
In addition, the invention also provides a preparation method of the choline chloride feed additive, which comprises the following steps:
(1) respectively weighing choline chloride, chitosan and bean dreg powder according to parts by weight;
(2) dissolving chitosan in acetic acid solution, stirring to obtain chitosan acetic acid solution, and standing;
(3) adding choline chloride into the chitosan acetic acid solution to obtain a mixed solution;
(4) adding bean dreg powder into the mixed solution, heating in a constant-temperature water bath, carrying out vacuum filtration, sequentially washing with absolute ethyl alcohol and distilled water respectively, and carrying out vacuum drying to finally prepare the choline chloride feed additive.
Preferably, the mass fraction of the acetic acid solution in the step (2) is 5%.
Preferably, the volume of the acetic acid solution in step (2) is 60-100 mL.
Preferably, the heating time of the thermostatic water bath in the step (4) is 7-8 h.
Preferably, the temperature of the thermostatic waterbath in the step (4) is 60-80 ℃.
Preferably, the vacuum drying time in step (4) is 3-5 h.
Preferably, the temperature of the vacuum drying in the step (4) is 60-70 ℃.
Compared with the prior art, the invention has the beneficial effects that:
(1) the choline chloride feed additive disclosed by the invention has good antibacterial property, is not easy to oxidize and disperse in water, does not cake within 3 months, improves the storage effect of the feed, and effectively prolongs the storage time of the choline chloride feed additive. Under acidic condition, the chitosan is easy to dissolve, and the dissolved chitosan contains amino (NH)2+) The amino groups are combined with choline chloride and the bean dreg powder, so that on one hand, the activity of bacteria in the air can be inhibited, the choline chloride feed additive is prevented from being oxidized, on the other hand, the activity of calcium ions, phosphorus ions and iron ions in the bean dreg powder can be inhibited, and the oxidation resistance is realized. Therefore, under the interaction of the chitosan, the choline chloride and the bean dreg powder, the invention effectively prolongs the storage time of the choline chloride feed additive, is not easy to deteriorate and does not influence the taste;
(2) because the bean dreg powder contains trace elements such as calcium, phosphorus, iron and the like, and the chitosan chloride is an amino polysaccharide, under the combined action of the bean dreg powder and the chitosan chloride, the absorption of animal cells to the trace elements is effectively promoted, the comprehensive and balanced nutritional ingredients of animals are ensured, the dual nutritional effects of the trace elements and amino groups are provided for the animals, the immunity and the anti-stress capability of the animals are effectively improved, diseases are prevented, the constipation of the animals is prevented, and the reproductive performance of the animals is further improved;
(3) the invention has good taste, no toxic or side effect, no chemical antioxidant and no toxic or side effect, completely abandons the harm of the chemical antioxidant to animals, can be added into the feed of the animals, and is suitable for long-term use;
(4) the preparation method is simple, the raw materials are few, and the cost is low.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
The choline chloride feed additive comprises, by weight, 50 parts of choline chloride, 1 part of chitosan chloride and 10 parts of bean dreg powder.
A preparation method of choline chloride feed additive is characterized by comprising the following steps: the method comprises the following steps:
(1) respectively weighing 50 parts of choline chloride, 1 part of chlorinated chitosan and 10 parts of bean dreg powder;
(2) dissolving 1 part of chlorinated chitosan in 60mL of 5% acetic acid solution, uniformly stirring to obtain a chitosan acetic acid solution, and standing for 30 mim;
(3) adding 50 parts of choline chloride into the chitosan acetic acid solution to obtain a mixed solution;
(4) adding 10 parts of bean dreg powder into the mixed solution, heating in a constant-temperature water bath at 60 ℃ for 7 hours, carrying out vacuum filtration, sequentially washing with absolute ethyl alcohol and distilled water for 3 times respectively, and carrying out vacuum drying at 60 ℃ for 3 hours to finally prepare the choline chloride feed additive.
Example 2
A choline chloride feed additive comprises, by weight, 60 parts of choline chloride, 2 parts of chitosan chloride and 13 parts of bean dreg powder.
A preparation method of choline chloride feed additive is characterized by comprising the following steps: the method comprises the following steps:
(1) respectively weighing 60 parts of choline chloride, 2 parts of chlorinated chitosan and 13 parts of bean dreg powder;
(2) dissolving 2 parts of chlorinated chitosan in 80mL of 5% acetic acid solution, uniformly stirring to obtain a chitosan acetic acid solution, and standing for 30 mim;
(3) adding 60 parts of choline chloride into the chitosan acetic acid solution to obtain a mixed solution;
(4) adding 13 parts of bean dreg powder into the mixed solution, heating in a constant-temperature water bath at 70 ℃ for 7.5 hours, carrying out vacuum filtration, sequentially washing with absolute ethyl alcohol and distilled water for 3 times respectively, and carrying out vacuum drying at 65 ℃ for 4 hours to finally prepare the choline chloride feed additive.
Example 3
A choline chloride feed additive comprises, by weight, 70 parts of choline chloride, 3 parts of chitosan chloride and 15 parts of bean dreg powder.
A preparation method of choline chloride feed additive is characterized by comprising the following steps: the method comprises the following steps:
(1) respectively weighing 70 parts of choline chloride, 3 parts of chlorinated chitosan and 15 parts of bean dreg powder;
(2) dissolving 3 parts of chlorinated chitosan in 100mL of 5% acetic acid solution, uniformly stirring to obtain a chitosan acetic acid solution, and standing for 30 mim;
(3) adding 70 parts of choline chloride into the chitosan acetic acid solution to obtain a mixed solution;
(4) adding 15 parts of bean dreg powder into the mixed solution, heating in a water bath with a constant temperature of 80 ℃ for 8 hours, carrying out vacuum filtration, sequentially washing with absolute ethyl alcohol and distilled water for 3 times respectively, and carrying out vacuum drying at 70 ℃ for 5 hours to finally prepare the choline chloride feed additive.
Comparative example 1
The composition of the choline chloride feed additive of comparative example 1 was substantially the same as that of the choline chloride feed additive of example 1 except that: 1 part of chitosan is used for replacing 1 part of the chlorinated chitosan in the example 1, and other components are kept unchanged, so that the components of the choline chloride feed additive in the comparative example 1 are obtained.
The choline chloride feed additive of comparative example 1 was prepared in the same manner as that of example 1, and finally prepared.
Comparative example 2
The composition of the choline chloride feed additive of comparative example 2 was substantially the same as that of the choline chloride feed additive of example 1 except that: 1 part of chitosan chloride in the components of the choline chloride feed additive in the example 1 is removed, and other components are kept unchanged, so that the components of the choline chloride feed additive in the comparative example 2 are obtained.
The choline chloride feed additive of comparative example 2 was prepared in the same manner as that of example 1, and finally prepared.
Comparative example 3
The composition of the choline chloride feed additive of comparative example 3 was substantially the same as that of the choline chloride feed additive of example 1 except that: 10 parts of bean dregs powder in the components of the choline chloride feed additive in the example 1 is removed, and other components are kept unchanged, so that the components of the choline chloride feed additive in the comparative example 3 are obtained.
The choline chloride feed additive of comparative example 3 was prepared in the same manner as that of example 1, and finally, a choline chloride feed additive was prepared.
Comparative example 4
The composition of the choline chloride feed additive of comparative example 4 was the same as that of the choline chloride feed additive of example 1.
The choline chloride feed additive of comparative example 4 was prepared in substantially the same manner as that of example 1, except that the step (2): 60mL of 5% acetic acid solution in step (2) of example 1 was replaced with 60mL of deionized water, and other steps were not changed to finally prepare a choline chloride feed additive.
Comparative example 5
The composition of the choline chloride feed additive of comparative example 5 was the same as that of the choline chloride feed additive of example 1.
The choline chloride feed additive of comparative example 5 was prepared in substantially the same manner as that of example 1, except that the step (2): 60mL of 5% acetic acid solution in the step (2) of example 1 was replaced by 60mL of 1% acetic acid solution, and other steps were not changed, thereby finally obtaining the choline chloride feed additive.
Comparative example 6
The components of the choline chloride feed additive of comparative example 6 were the same as those of example 1.
The choline chloride feed additive of comparative example 6 was prepared substantially in the same manner as the choline chloride feed additive of example 1, except for the difference in step (4): the heating time of the thermostatic water bath is 9h, and other steps are unchanged, so that the choline chloride feed additive is finally prepared.
Comparative example 7
The components of the choline chloride feed additive of comparative example 7 were the same as those of example 1.
The choline chloride feed additive of comparative example 7 was prepared in substantially the same manner as that of example 1, except that the process of step (4): the temperature of the thermostatic water bath is 90 ℃, and other steps are unchanged, so that the choline chloride feed additive is finally prepared.
Open air weight gain test
10g of choline chloride feed additive according to examples 1 to 3 and comparative examples 1 to 7 of the present invention was accurately weighed by an analytical balance, and then placed in 100mL beakers, respectively, exposed to air, and left to stand for a period of time starting from 5/1/2017 and ending at 10/1/2017. The test results are shown in table 1.
TABLE 1 open air weight gain test of choline chloride feed additives
Through comparison of examples 1-3 with the choline chloride feed additives of comparative examples 1-7, it was found that the choline chloride feed additive of the present invention did not substantially increase weight and did not cake when exposed to air for 3 months; when the choline chloride feed additive is exposed in the air for 4-5 months, the weight is not obviously increased, which shows that the choline chloride feed additive has good moisture resistance and is not easy to be oxidized under the interaction of the chitosan, the choline chloride and the bean dreg powder, and the storage time of the choline chloride feed additive is effectively prolonged.
Laying duck feeding test
200 laying ducks are purchased in the market, randomly divided into 10 groups and fed normally under the same conditions, and the feeding times, the feeding amount and the feeding time are all the same. The choline chloride feed additives of examples 1-3 and comparative examples 1-7 of the invention are respectively added into the laying duck feed, 1g of the choline chloride feed additive is added into each kilogram of duck feed, and feeding is carried out according to the conventional feeding amount and times, wherein the feeding time is from 2018, 2 and 1 days to 2018, 5 and 1 days. The test results are shown in table 1.
TABLE 1 laying duck feeding test results
As can be seen from Table 1, through comparison between examples 1-3 and comparative examples 1-7, the choline chloride feed additive disclosed by the invention is added into the duck feed, so that the comprehensive and balanced animal nutritional ingredients are ensured, the palatability is good, the feed intake of laying ducks can be increased, the weight of the laying ducks is increased, diseases are prevented, animal constipation is prevented, the reproductive performance of animals is improved, the reproductive performance of the laying ducks is improved, the color of egg yolk is good, and the nutrition is high. In addition, the choline chloride feed additive is not added with any chemical antioxidant, has no toxic or side effect, and is suitable for long-term use.
The above embodiments are only some examples of the present invention, and the present invention is not limited thereto in any way, and any simple modification, equivalent change and modification to the above embodiments according to the technical spirit of the present invention are within the technical scope of the present invention.
Claims (5)
1. A choline chloride feed additive is characterized in that: the raw materials comprise, by weight, 50-70 parts of choline chloride, 1-3 parts of chitosan and 10-15 parts of bean dreg powder, wherein the chitosan is chitosan chloride, and the preparation method of the choline chloride feed additive comprises the following steps:
(1) respectively weighing choline chloride, chitosan and bean dreg powder according to parts by weight;
(2) dissolving chitosan in an acetic acid solution, uniformly stirring to obtain a chitosan acetic acid solution, and standing, wherein the mass fraction of the acetic acid solution is 5%;
(3) adding choline chloride into the chitosan acetic acid solution to obtain a mixed solution;
(4) adding bean dreg powder into the mixed solution, heating in a constant-temperature water bath, carrying out vacuum filtration, sequentially washing with absolute ethyl alcohol and distilled water respectively, and carrying out vacuum drying to finally prepare the choline chloride feed additive, wherein the heating time of the constant-temperature water bath is 7-8h, and the temperature of the constant-temperature water bath is 60-80 ℃.
2. The choline chloride feed additive of claim 1, wherein: the raw materials comprise, by weight, 60 parts of choline chloride, 2 parts of chitosan and 13 parts of bean dregs powder.
3. The method for preparing choline chloride feed additive according to claim 1, wherein: the volume of the acetic acid solution in the step (2) is 60-100 mL.
4. The method for preparing choline chloride feed additive according to claim 1, wherein: the vacuum drying time in the step (4) is 3-5 h.
5. The method for preparing choline chloride feed additive according to claim 1, wherein: the temperature of the vacuum drying in the step (4) is 60-70 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811382203.6A CN109393195B (en) | 2018-11-20 | 2018-11-20 | Choline chloride feed additive and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811382203.6A CN109393195B (en) | 2018-11-20 | 2018-11-20 | Choline chloride feed additive and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109393195A CN109393195A (en) | 2019-03-01 |
| CN109393195B true CN109393195B (en) | 2022-01-11 |
Family
ID=65474167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811382203.6A Active CN109393195B (en) | 2018-11-20 | 2018-11-20 | Choline chloride feed additive and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109393195B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0622703A (en) * | 1990-10-11 | 1994-02-01 | Quimica Mobi Sa | Animal feed additive based on choline chloride |
| CN101695337A (en) * | 2009-10-09 | 2010-04-21 | 徐州汉威饲料有限公司 | Choline chloride powder containing 50 percent of pomace carriers |
| CN102630817A (en) * | 2011-02-14 | 2012-08-15 | 河北农业大学 | Rumen-protected chlorine chloride microcapsule additive and preparation method thereof |
| CN105285448A (en) * | 2015-10-26 | 2016-02-03 | 张静 | Vinegar residue meat duck high-efficient feed loading modified choline and preparation method thereof |
-
2018
- 2018-11-20 CN CN201811382203.6A patent/CN109393195B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0622703A (en) * | 1990-10-11 | 1994-02-01 | Quimica Mobi Sa | Animal feed additive based on choline chloride |
| CN101695337A (en) * | 2009-10-09 | 2010-04-21 | 徐州汉威饲料有限公司 | Choline chloride powder containing 50 percent of pomace carriers |
| CN102630817A (en) * | 2011-02-14 | 2012-08-15 | 河北农业大学 | Rumen-protected chlorine chloride microcapsule additive and preparation method thereof |
| CN105285448A (en) * | 2015-10-26 | 2016-02-03 | 张静 | Vinegar residue meat duck high-efficient feed loading modified choline and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| "改性壳聚糖在环境痕量元素及其形态分析中的应用"，代军，B027-48，中国优秀博硕士学位论文全文数据库（博士） 工程科技Ⅰ辑;代军;《改性壳聚糖在环境痕量元素及其形态分析中的应用》;中国优秀博硕士学位论文全文数据库（博士）;20140331;第31页引言部分第2段第2-3行、第32页4.2.3部分的第1段、第33页最后一段、第34页最后一段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109393195A (en) | 2019-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102835610B (en) | Feed additive for broiler chickens and preparation method thereof | |
| US10178871B2 (en) | Herbaceous selenium-enriched SOD non-antibiotic feed and method of manufacture thereof | |
| CN101889634A (en) | Organic selenium-supplementing feed additive and preparation and using method thereof | |
| CN102217738A (en) | Pet dog feed | |
| CN105309800A (en) | Flavoring agent for improving favor of stress pig feed | |
| CN102429099A (en) | Pet cat feed | |
| WO2023077877A1 (en) | Feed additive for improving intestinal health of weaned kittens and preparation method therefor | |
| JPH035783B2 (en) | ||
| CN109393195B (en) | Choline chloride feed additive and preparation method thereof | |
| CN106333081B (en) | Feed additive containing amino acid | |
| CN105309782A (en) | Orange-flavor pig feed flavoring agent | |
| RU2366271C1 (en) | Forage additive as preventive and treatment medium for domestic and farm animals | |
| KR20190061703A (en) | Functional feed additive to increase DHA content in Pork Belly, and processing method of it | |
| CN110604230A (en) | Preparation method of dog food phagostimulant with good palatability | |
| CN106306480B (en) | Additive comprising sodium glutamate | |
| CN112136977A (en) | Pigeon feed additive for promoting ingestion and improving health and application thereof | |
| US20160286832A1 (en) | Methods of feeding animals fermentation cell mass | |
| CN106333082B (en) | Preparation method of amino acid compound feed additive | |
| RU2321268C2 (en) | Fodder for broiler chickens | |
| CN111903855B (en) | Composition for livestock feed and application thereof | |
| CN109007330A (en) | Desmodium intortum herbage particle and its processing method | |
| KR101472669B1 (en) | Assorted feed composition comprising makgeolli byproduct for farming a Sebastes schlegeli | |
| CN112640996B (en) | Nutritional additive for improving pork quality | |
| CN106359896B (en) | Preparation process of additive containing sodium glutamate | |
| CN109393160A (en) | A kind of choline chloride powder and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |