CN109382054A - The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin - Google Patents
The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin Download PDFInfo
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- CN109382054A CN109382054A CN201811491870.8A CN201811491870A CN109382054A CN 109382054 A CN109382054 A CN 109382054A CN 201811491870 A CN201811491870 A CN 201811491870A CN 109382054 A CN109382054 A CN 109382054A
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- reaction chamber
- shell
- reaction
- chelate complexes
- norfloxacin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0073—Sealings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00058—Temperature measurement
- B01J2219/00063—Temperature measurement of the reactants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00132—Controlling the temperature using electric heating or cooling elements
- B01J2219/00135—Electric resistance heaters
Abstract
The invention discloses the after-treatment devices of Boron chelate complexes in a kind of production of Norfloxacin, including shell, reaction chamber is equipped in the shell, middle part is equipped with stirring motor below the reaction chamber, the stirring motor is fixed on reaction chamber bottom by bracket, setting stirring is to make them flow to accelerate reaction speed to be stirred during the reaction to the indoor compound of reaction.The present invention provides the after-treatment devices of Boron chelate complexes in a kind of production of Norfloxacin, structure setting is ingenious and reasonable, anti-corrosion layer, insulating layer, shock-resistant layer are provided in interlayer, anti-corrosion layer is in innermost end, there is injury of corrosive compound to shell for obstructing, insulating layer reaction chamber heat with when freezing to reacting indoor temperature progress constant temperature, play the role of ensureing the steady of reaction room temperature, shock-resistant layer is in outermost end, for impact force of the foreign object to shell during Absorption And Transportation, production etc., the stability and safety of maintenance device.
Description
Technical field
The present invention relates to Norfloxacin production technology apparatus field, Boron chelate complexes in specifically a kind of Norfloxacin production
After-treatment device.
Background technique
Norfloxacin, alias: Eoroxin, orfloxacin, leaching jinx.The entitled fluoro- 1,4- dihydro -4- of 1- ethyl -6- of its chemistry
Oxo -7- (1- piperazinyl) -3- quinoline carboxylic acid.This product is third generation Comprecin, can hinder to cause a disease in alimentary canal thin
The effect of the DNA gyrase of bacterium hinders bacterium DNA replication, has inhibiting effect to bacterium.It is the common medicine for treating enteritis and dysentery.
But this medicine is formed with retarding action to minor's bone, influences whether to develop, therefore minor is forbidden to take.
In the preparation process of Norfloxacin, wherein being added by acetic anhydride, anhydrous zinc chloride, boric acid and ethyl compound
Thermal response obtains boron chela compound, and boron chela compound utilizes ethyl alcohol that crude product is precipitated after reacting with DMSO, piperazine, triethylamine, then
Crude product is reacted with the double ethyl esters of boric acid, ethyl alcohol, triethylamine heating, finally obtains white crystalline powder product.
Existing reaction treating device is reacted between the same compound of thousand changes to obtain the institute of next procedure
Raw material is needed, the number of reaction yield is influenced by reasons such as compound quality, proportion, the control of temperature and pressure, new and old technologies of preparing, deposited
In very big unstability, and the most effective yield that improves can only rely on the appearance of new glass forming theory, and new glass forming theory needs
Scientific research personnel's tackling key problem that studies for a long period of time cannot be realized in the short time, and existing compound quality, proportion, temperature and pressure control etc. are being stablized
In the case of means, yield is further increased at cost is reduced between enterprise, is improved quality and is asked with necessity solution when occupation rate of market
Topic.
Summary of the invention
It is above-mentioned to solve the purpose of the present invention is to provide the after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin
The problem of being proposed in background technique.
To achieve the above object, the invention provides the following technical scheme:
The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin, including shell are equipped with reaction chamber in the shell, described
The left and right sides is respectively equipped with feed inlet and outlet close to top on reaction chamber, and feed inlet and outlet are in order in preparation section
Facilitate in the process and new reaction raw materials are added, outlet plays main function in the links such as distillation, suction filtration；
Cap is equipped at the top of the reaction chamber, reaction chamber side, the work of folding are fixed on by movable axis activity in described cap one end
The more traditional reaction kettle totally enclosed type of dynamic fixation facilitates cleaning and maintenance in reaction kettle；Middle part is equipped with ultrasonic wave on the cap
Generator, the supersonic generator have the pedestal through cap, are equipped with ultrasonic waves on the pedestal in the cap
Energy device, the supersonic generator are connect with external circuit；
Right side is equipped with temperature inductor close to lower section in the reaction chamber, and indoor temperature feelings are reacted in the detection of temperature inductor moment
Condition, and feedback information, conducive to the control to temperature in reaction process；Middle part is equipped with stirring motor below the reaction chamber, described
Stirring motor is fixed on reaction chamber bottom by bracket, and the arbor of the stirring motor protrudes into reaction chamber, and the reaction is indoor
Arbor is equipped with round roller, and the round roller is equipped with stirring blade, and setting stirring is in order to indoor to reaction during the reaction
Compound is stirred, and is made them flow to accelerate reaction speed, is improved working efficiency；
Right side is equipped with control cabinet close to lower section on the shell, and control cabinet is also wrapped for the control to entire processing unit
The monitoring for including device operating condition such as temperature facilitates assurance of the producers to production link；Stirring motor under the shell
The left and right sides is equipped with collection port, and the collection port is to be arranged through shell and reaction chamber, and collection port is for collecting at Boron chelate complexes
Semifinished product after reason.
Further, the outer casing bottom is equipped with support column, and support column supports fixing shell, and is to stir by aerial construction
It mixes motor and installation space is provided.
Further, interlayer is equipped between the shell and reaction chamber, sandwich establishment may when allowing for practical application
The some problems occurred, therefore counter-measure is given in advance, it prevents trouble before it happens.
Further, the interlayer is followed successively by anti-corrosion layer, insulating layer, shock-resistant layer from inside to outside and is connected to form, corrosion resistant
Erosion layer is in innermost end, has injury of corrosive compound to shell for obstructing, insulating layer is heated and made in reaction chamber
To indoor temperature progress constant temperature is reacted when cold, play the role of ensureing that the steady of reaction room temperature, shock-resistant layer are in outermost
End, for impact force of the foreign object to shell during Absorption And Transportation, production etc., the stability and safety of maintenance device.
Further, close to condenser pipe is equipped at reaction chamber at left and right sides of the interlayer, the condenser pipe is Multi-layered wound
Reaction chamber setting；Condenser pipe is refrigeration purposes, and semifinished product is precipitated in cooling after ethyl alcohol is added for Boron chelate complexes.
Further, reaction chamber bottom is equipped with heating wire in the interlayer, and heating wire heats reaction chamber,
Acetic anhydride and anhydrous zinc chloride are to needing for temperature to be promoted to 116 DEG C or so in the reaction process of boric acid, while DMSO and boron chelate
80 DEG C of temperature or so are also required to when object, piperazine reaction.
Compared with prior art, the present invention have the following aspects the utility model has the advantages that
1. the present invention conducts ultrasonic wave to transmitting interior when reaction, ultrasonic wave creatively by setting supersonic generator
The constantly refraction and reflection in reaction chamber, while the molecular structure between Boron chelate complexes is trembleed, by molecular structure loose and tear open
It opens, facilitates the reaction between compound, substantially increase reaction efficiency, and reaction raw materials are maximumlly utilized, reduce
The case where waste, reduces the production cost of enterprise, reduces the retail price of Norfloxacin, so that the medical fee of patient obtains
To reduction.
2. the present invention at the top of reaction chamber by being arranged cap, reaction chamber is fixed on by movable axis activity in described cap one end
Side, the fixed more traditional reaction kettle totally enclosed type of the activity of folding facilitates cleaning and maintenance in reaction kettle, in addition of the invention
It is equipped with temperature inductor and rabbling mechanism in reaction chamber, facilitate stability monitoring and improves reaction efficiency.
3. the present invention is close to condenser pipe is equipped at reaction chamber at left and right sides of the interlayer, condenser pipe is that Multi-layered wound reacts
Room setting；Cooling efficiency and cooling effect when greatly improving cooling process；Present invention reaction chamber bottom in the interlayer is equipped with
Heating wire facilitates the heating in heating process.
4. the present invention is equipped with interlayer between the shell and reaction chamber, sandwich establishment may when allowing for practical application
The some problems occurred, therefore counter-measure is given in advance, it prevents trouble before it happens；The interlayer is followed successively by corrosion-resistant from inside to outside
Layer, insulating layer, shock-resistant layer are connected to form, and anti-corrosion layer is in innermost end, have corrosive compound external for obstructing
The injury of shell, insulating layer, to indoor temperature progress constant temperature is reacted, are played and are ensured in reaction chamber when reaction chamber is heated with refrigeration
The steady effect of temperature, shock-resistant layer are in outermost end, for collision of the foreign object to shell during Absorption And Transportation, production etc.
Power, the stability and safety of maintenance device.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the after-treatment device of Boron chelate complexes in Norfloxacin production.
Fig. 2 is the structural schematic diagram of interlayer in the after-treatment device of Boron chelate complexes in Norfloxacin production.
Fig. 3 is the structural schematic diagram of cap in the after-treatment device of Boron chelate complexes in Norfloxacin production.
In figure: 1, shell；2, interlayer；3, condenser pipe；4, reaction chamber；5, feed inlet；6, movable axis；7, cap；8, ultrasonic
Wave producer；9, outlet；10, control cabinet；11, temperature inductor；12, support column；13, heating wire；14, collection port；15, it holds in the palm
Frame；16, stirring motor；17, arbor；18, round roller；19, stirring blade；20, anti-corrosion layer；21, insulating layer；22, shock-resistant layer；
23, ultrasonic transducer；24, pedestal.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Referring to Fig. 1, in a kind of production of Norfloxacin Boron chelate complexes after-treatment device, including shell 1, the shell 1
Bottom is equipped with support column 12, is equipped with reaction chamber 4 in the shell 1, and interlayer 2 is equipped between the shell 1 and reaction chamber 4, described
The left and right sides of interlayer 2 is close to condenser pipe 3 is equipped at reaction chamber 4, and the condenser pipe 3 is that Multi-layered wound reaction chamber 4 is arranged, the folder
4 bottom of reaction chamber is equipped with heating wire 13 in layer 2, on the reaction chamber 4 left and right sides close to top difference portion be equipped with feed inlet 5 with
Outlet 9；
Right side is equipped with temperature inductor 11 close to lower section in the reaction chamber 4, is equipped with cap 7, the shell at the top of the reaction chamber 4
4 side of reaction chamber is fixed on by 6 activity of movable axis in 7 one end of lid；
The 4 lower section middle part of reaction chamber is equipped with stirring motor 16, and the stirring motor 16 is fixed on 4 bottom of reaction chamber by bracket 15
The arbor 17 in portion, the stirring motor 16 protrudes into reaction chamber 4, and the arbor 17 in the reaction chamber 4 is equipped with round roller 18, described
Round roller 18 is equipped with stirring blade 19, and right side is equipped with control cabinet 10, the lower stirring electricity of the shell 1 close to lower section on the shell 1
Collection port 14 is equipped at left and right sides of machine 16, the collection port 14 is to be arranged through shell 1 and reaction chamber 4；
Please refer to Fig. 2-3, the interlayer 2 is followed successively by anti-corrosion layer 20, insulating layer 21, shock-resistant layer 22 from inside to outside and is connected group
At, middle part is equipped with supersonic generator 8 on the cap 7, and the supersonic generator 8 has the pedestal 24 through cap 7,
Ultrasonic transducer 23 is installed, the supersonic generator 8 is connect with external circuit in the cap 7 on pedestal 24.
The working principle of the invention is: the present invention provides the after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin,
Structure setting is ingenious and reasonable, is closed cap 7 by movable axis 6 when use, is then added by feed inlet 5 former needed for reaction
Material, raw material reacted in reaction chamber 4, and stirring motor 16 is powered operation at this time, drive stirring blade 19 in reaction chamber 4 into
Row rotation comes into full contact with reaction so that the air-flow in reaction chamber 4 is sprung up between compound, improve reaction efficiency；
The heating wire 13 of reaction chamber bottom heats reaction chamber in the reaction process of acetic anhydride and anhydrous zinc chloride to boric acid
Work, provides required temperature condition for the combination reaction of boric acid, when ethyl alcohol, which is added, in Boron chelate complexes needs that crude product is precipitated, instead
It answers the condenser pipe 3 of 4 four wall of room to carry out cooling work to reaction chamber, provides the precipitation low temperature of needs for ethyl alcohol, all in all pass through
Heater strip 13 and condenser pipe 3 may be implemented to provide required temperature various in Boron chelate complexes reaction process, and set in reaction chamber 4
It is equipped with temperature inductor 11, moment detection reaction room temperature provides properly stable operating temperature for reaction process；
Supersonic generator 8 is provided on the cap 7 of reaction chamber 4 simultaneously, supersonic generator 8 enters reaction by pedestal 24
Interior is simultaneously launched in reaction chamber 4 by ultrasonic transducer 23, ultrasonic wave constantly refraction and reflection in reaction chamber, together
When trembling Boron chelate complexes between molecular structure, by molecular structure loose and dismantle, facilitate the reaction between compound, greatly
The case where improving reaction efficiency greatly, and reaction raw materials be maximumlly utilized, reduce waste；
The interlayer 2 of multilayered structure composition is provided between shell 1 and reaction chamber 4, anti-corrosion layer 20 is in innermost end, for hindering
Every the injury with corrosive compound to shell 1, insulating layer 21 is when reaction chamber 4 is heated with refrigeration in reaction chamber 4
Temperature carry out constant temperature, play the role of ensure reaction chamber 4 in temperature it is steady, shock-resistant layer 22 be in outermost end, for absorb transport
Impact force of the foreign object to shell during defeated, production etc., the stability and safety of maintenance device.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected;It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood by concrete condition
Concrete meaning in the present invention.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
Various changes can be made.
Claims (6)
1. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production, including shell (1), which is characterized in that the shell
(1) reaction chamber (4) are equipped in, the left and right sides is respectively equipped with feed inlet (5) and outlet close to top on the reaction chamber (4)
(9)；Cap (7) are equipped at the top of the reaction chamber (4), reaction chamber is fixed on by movable axis (6) activity in described cap (7) one end
(4) side, middle part is equipped with supersonic generator (8) on the cap (7), and the supersonic generator (8) has through shell
The pedestal (24) of (7) is covered, is equipped with ultrasonic transducer (23) on the pedestal (24) in the cap (7), the ultrasonic wave hair
Raw device (8) are connect with external circuit；
Right side is equipped with temperature inductor (11) close to lower section in the reaction chamber (4), and middle part is equipped with and stirs below the reaction chamber (4)
It mixes motor (16), the stirring motor (16) is fixed on reaction chamber (4) bottom, the machine of the stirring motor (16) by bracket (15)
Axis (17) protrudes into reaction chamber (4), and the arbor (17) in the reaction chamber (4) is equipped with round roller (18), on the round roller (18)
Equipped with stirring blade (19), right side is equipped with control cabinet (10) close to lower section on the shell (1), and electricity is stirred under the shell (1)
Collection port (14) are equipped at left and right sides of machine (16), the collection port (14) is to be arranged through shell (1) and reaction chamber (4).
2. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production according to claim 1, which is characterized in that institute
Shell (1) bottom is stated equipped with support column (12).
3. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production according to claim 1, which is characterized in that institute
It states and is equipped with interlayer (2) between shell (1) and reaction chamber (4).
4. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production according to claim 3, which is characterized in that institute
It states interlayer (2) and is followed successively by anti-corrosion layer (20), insulating layer (21), shock-resistant layer (22) from inside to outside and be connected to form.
5. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production according to claim 3, which is characterized in that institute
It states close to condenser pipe (3) are equipped at reaction chamber (4) at left and right sides of interlayer (2), the condenser pipe (3) is Multi-layered wound reaction chamber
(4) it is arranged.
6. the after-treatment device of Boron chelate complexes in a kind of Norfloxacin production according to claim 3, which is characterized in that institute
Interlayer (2) interior reaction chamber (4) bottom is stated equipped with heating wire (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811491870.8A CN109382054A (en) | 2018-12-07 | 2018-12-07 | The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811491870.8A CN109382054A (en) | 2018-12-07 | 2018-12-07 | The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin |
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| CN109382054A true CN109382054A (en) | 2019-02-26 |
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| CN201811491870.8A Pending CN109382054A (en) | 2018-12-07 | 2018-12-07 | The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110981853A (en) * | 2019-12-17 | 2020-04-10 | 安徽赛诺制药有限公司 | Preparation method of besifloxacin hydrochloride |
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| CN209302735U (en) * | 2018-12-07 | 2019-08-27 | 洛阳天疆精细化工有限公司 | The after-treatment device of Boron chelate complexes in a kind of production of Norfloxacin |
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2018
- 2018-12-07 CN CN201811491870.8A patent/CN109382054A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007332335A (en) * | 2006-06-10 | 2007-12-27 | Shinichiro Kojima | Coke creating apparatus including fully automated, waste tire, and whole waste rubber liquefaction through extraction of oil component |
| CN206276366U (en) * | 2016-12-22 | 2017-06-27 | 冯海萍 | A kind of ultrasonic wave medicament reaction unit |
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