CN109381783A - Drug coated balloon catheter - Google Patents
Drug coated balloon catheter Download PDFInfo
- Publication number
- CN109381783A CN109381783A CN201710653108.4A CN201710653108A CN109381783A CN 109381783 A CN109381783 A CN 109381783A CN 201710653108 A CN201710653108 A CN 201710653108A CN 109381783 A CN109381783 A CN 109381783A
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- Prior art keywords
- coated balloon
- catheter
- medicine
- push
- sacculus
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- 239000003814 drug Substances 0.000 title claims abstract description 273
- 229940079593 drug Drugs 0.000 title claims abstract description 116
- 230000033001 locomotion Effects 0.000 claims abstract description 16
- 230000004323 axial length Effects 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims description 26
- 238000000576 coating method Methods 0.000 claims description 26
- 230000007246 mechanism Effects 0.000 claims description 26
- 230000002792 vascular Effects 0.000 abstract description 12
- 230000005540 biological transmission Effects 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 8
- 230000001681 protective effect Effects 0.000 abstract description 4
- 210000004204 blood vessel Anatomy 0.000 description 31
- 238000010586 diagram Methods 0.000 description 19
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 239000002775 capsule Substances 0.000 description 10
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 230000003902 lesion Effects 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000002503 metabolic effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000004804 winding Methods 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000004262 dental pulp cavity Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 241001563035 Clinopodium polycephalum Species 0.000 description 1
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 235000010599 Verbascum thapsus Nutrition 0.000 description 1
- 244000178289 Verbascum thapsus Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229960001592 paclitaxel Drugs 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 229920009441 perflouroethylene propylene Polymers 0.000 description 1
- -1 polyethylene pyrrole Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention discloses a kind of drug coated balloon catheter, including with certain axial length push conduit, at least one is set to the medicine-coated balloon of push distal end of catheter and is actively sheathed on sheath outside the medicine-coated balloon.Sheath can be contained in sheath before expansion along the axial movement of push conduit, medicine-coated balloon.Drug coated balloon catheter of the invention is during transportation; sheath has protective effect to the medication coat on medicine-coated balloon surface; blood flow is avoided to wash away medication coat; after reaching diseased region; slidable sheath is proximally dropped back; medicine-coated balloon, which is stretched out from sheath and is exposed in vascular environment, to be filled, so that the drug loss rate being effectively reduced in transmission process, improves the effectiveness and reliability of drug coated balloon catheter.
Description
Technical field
The invention belongs to the field of medical instrument technology, are related to interventional medical device, and in particular to a kind of medicine-coated balloon
Conduit.
Background technique
Narrow arteries is a kind of common disease, and the narrow therapeutic modality of arteries, which is mainly included in diseased region, to be made
With naked balloon expandable, the implantation modes such as bare bracket or drug stent.Above-mentioned therapeutic modality all has different defects.
Drug coated balloon catheter refers to the foley's tube in common bare ball capsule area load medication coat, medicine to be loaded with
After the sacculus of object is delivered to diseased region, balloon expandable makes the vascular wall of diseased region restore unimpeded, while medication coat is certainly
Balloon surface is eluted and is discharged to vascular wall, can be further suppressed the hyperplasia of smooth muscle cell, be prevented reangiostenosis.Therefore,
Drug coated balloon catheter not only can be that blood fortune establishes channel, but also can avoid the postoperative bracket of stenter to implant by balloon expandable
The defects of interior restenosis, thrombus.
The drug coated balloon catheter of the prior art is usually using the foley's tube only with a sacculus, in the sacculus
Outer surface applies medication coat, then will carry medicine ball capsule and be delivered to after diseased region and expanded according to the characteristics of diseased region.But
It is in the transmission process of this drug coated balloon catheter in the blood vessels, due to being washed away by swiftly flowing blood, drug is damaged
Mistake rate is up to 50% or more, to reduce medicine-coated balloon in the releasable dose of diseased region, influences instrument validity；Together
When, after the drug washed away by blood falls off, distal vessels can be also blocked, and increase the metabolic burden of body, reduce instrument
Safety.In addition, in order to guarantee to have enough drug to reach lesion locations, the prior art can also take the initial load medicine for increasing sacculus
The method of amount, but this mode both will increase equipment cost, can also aggravate the metabolic burden of body, reduce instrument safety.
Based on this, it is necessary to a kind of drug coated balloon catheter is provided, the drug loss in transmission process can be effectively reduced,
It avoids drug from falling off to block distal vessels or aggravate the metabolic burden of body, while reducing initial drugloading rate, it is raw to reduce instrument
Produce cost.
Summary of the invention
The technical problem to be solved in the present invention is that in view of the drawbacks of the prior art, a kind of medicine-coated balloon is provided and is led
Pipe can efficiently reduce and carry medicine ball capsule drug loss during transportation, increase drug coated balloon catheter validity and
Safety, while initial drugloading rate is reduced, reduce instrument production cost.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of drug coated balloon catheter, including with the push conduit of certain axial length and at least one be set to push
The medicine-coated balloon of distal end of catheter.Medicine-coated balloon includes expandable balloon and at least partly covers expandable balloon surface
Active medicine coating.Drug coated balloon catheter further includes the sheath being actively sheathed on outside medicine-coated balloon, and is protected
Axial movement of the set along pushed conduit.Medicine-coated balloon is contained in sheath before expansion.
In a wherein technical solution, the distal end of sheath is equipped with shrinking hood.It is gradually received to push conduit shrinking hood distal end
Hold together and covers push distal end of catheter.Shrinking hood edge is axially arranged at least one expandable expansion joint.
In a wherein technical solution, the internal diameter of sheath is outer at largest outside diameter before expansion than medicine-coated balloon
Big 0~the 0.10mm of diameter.
In a wherein technical solution, push leads that at least one guidewire lumen is arranged in inner axial tube and at least one first is filled
It is full of chamber.Proximal end and distal end of the guidewire lumen axially through push conduit.First full chamber is connected to the inside of medicine-coated balloon.
In a wherein technical solution, drug coated balloon catheter further includes the catheter block set on push catheter proximal end.
Catheter block is equipped with guidewire port and at least one first full port.Guidewire port is connected with guidewire lumen.First full port
It is connected with the first full chamber.
In a wherein technical solution, drug coated balloon catheter further includes actively being sheathed on push catheter proximal end
Operation handle.The distal end of operation handle is directly connected to the proximal end of sheath or is indirectly connected with by hollow tube.
In a wherein technical solution, drug coated balloon catheter further includes at least one sliding catheter.Sliding catheter
Axially opposed push catheter movement.Sliding catheter distal end is equipped at least one second sacculus.It is axially disposed in sliding catheter
At least one second full chamber.The distal end of second full chamber is connected to the inside of the second sacculus.
In a wherein technical solution, the second sacculus is contained in sheath before expansion.
In a wherein technical solution, the drug coated balloon catheter further includes the second sheath, second sheath
It is actively sheathed on the outside of second sacculus, and the second sheath is along the axial movement of sliding catheter.Second sacculus is being expanded
Before be contained in the second sheath.
In a wherein technical solution, at least partly surface coated medicament coating of the second sacculus.
In a wherein technical solution, sliding catheter is actively set in the outside of push conduit or is arranged in push
The inside of conduit；Or sliding catheter and push conduit parallel arranged are arranged.
It in a wherein technical solution, is limited and is connected by locating part between sliding catheter and push conduit, so that sliding
Dynamic conduit and push conduit only axially opposed movement.
In a wherein technical solution, the proximal diameter of the active section of medicine-coated balloon and/or the second sacculus is greater than
The diameter of the rest part of the active section of the sacculus.
In a wherein technical solution, medicine-coated balloon dilating catheter further includes being set to sliding catheter and push conduit
Between locking mechanism.
In a wherein technical solution, locking mechanism includes the springy locking member being fixed on sliding catheter, snap lock
Holding push conduit locks the two after determining part rotation；
Or locking mechanism includes being fixed on the supravasal springy locking member of push, blocks sliding after springy locking member rotation
Conduit locks the two.
In a wherein technical solution, locking mechanism includes that setting exists in supravasal first locking piece of push and setting
The second locking piece on sliding catheter.It is detachably connected between first locking piece and the second locking piece.First locking piece and second
When locking piece connects, push fixed between conduit and sliding catheter.Disassembly is without even between the second locking piece of first locking piece and institute
When connecing, axially opposed movement between conduit and sliding catheter is pushed.
The present invention by least being had in the external of medicine-coated balloon using slidable sheath compared with prior art
Have it is following the utility model has the advantages that
In the transmission process of drug coated balloon catheter, sheath, which has the medication coat on medicine-coated balloon surface, to be protected
Shield effect, after reaching diseased region, slidable sheath is proximally dropped back, and medicine-coated balloon stretches out and sudden and violent from sheath
It is exposed in vascular environment, can avoid blood flow in transmission process as a result, and medication coat is washed away, conveyed to be effectively reduced
Drug loss rate in journey, improves the validity of drug coated balloon catheter；The drug that can avoid falling off simultaneously is washed away by blood
To distal vessels, blood vessel is blocked；Further, since reducing drug loss rate, the initial of medicine-coated balloon surface can also be reduced
Drugloading rate mitigates the metabolic burden of body, improves the safety of drug coated balloon catheter.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples, in attached drawing:
Fig. 1 is the structural schematic diagram of the first embodiment of the embodiment of the present invention one；
Fig. 2 is the structural schematic diagram of the sheath mechanism recession of the embodiment of the present invention one；
Fig. 3 is cross-sectional view of the embodiment of the present invention one in sheath position；
Fig. 4 is the structural schematic diagram of the sheath mechanism of the embodiment of the present invention one；
Fig. 5 is the structural schematic diagram of shrinking hood in the sheath mechanism of the embodiment of the present invention one；
Fig. 6 is the structural schematic diagram that the sheath mechanism shrinking hood of the embodiment of the present invention one is opened；
Fig. 7 is the structural schematic diagram of second of embodiment of the embodiment of the present invention one；
Fig. 8-10 is the structural schematic diagram of the push conduit of the embodiment of the present invention one；
Figure 11 is the structural schematic diagram of the first embodiment of the embodiment of the present invention two；
Figure 12 is the cross-sectional view of the embodiment of the present invention two；
Figure 13 is the first embodiment structure schematic diagram of the locking mechanism of the embodiment of the present invention two；
Figure 14 is second of embodiment structure schematic diagram of the locking mechanism of the embodiment of the present invention two；
Figure 15 to Figure 19 is the using process diagram of the drug coated balloon catheter of the embodiment of the present invention two, wherein figure
15 be the schematic diagram that drug coated balloon catheter reaches diseased region blood vessel, and Figure 16 is sheath recession, medicine-coated balloon exposure
Schematic diagram in the blood vessel, Figure 17 are the schematic diagrames adjusted after the second balloon position, and Figure 18 is the schematic diagram of the second balloon expandable,
Figure 19 is the schematic diagram of medicine-coated balloon expansion；
Figure 20 is the structural schematic diagram of the first embodiment of the embodiment of the present invention three；
Figure 21 is the cross-sectional view of the push conduit of the embodiment of the present invention three；
Figure 22 is the structural schematic diagram of second of embodiment of the embodiment of the present invention three；
Figure 23-25 is the structural schematic diagram of the sacculus of the embodiment of the present invention three.
Specific embodiment
For a clearer understanding of the technical characteristics, objects and effects of the present invention, now control attached drawing is described in detail
A specific embodiment of the invention.
Firstly the need of explanation, in intervention medical field, the one end that usually will be close to operator is referred to as proximal end, will be far from
One end of operator is referred to as distal end.
As shown in Fig. 1-2 5, a kind of drug coated balloon catheter, including with certain axial length push conduit 310,
At least one is set to the medicine-coated balloon 100 of push 310 distal end of conduit and is actively sheathed on outside medicine-coated balloon 100
The sheath 220 in portion.Medicine-coated balloon 100 includes expandable balloon and at least partly covers the active drug on expandable balloon surface
Object coating 30.Axial movement of the sheath 220 along push conduit 310.Medicine-coated balloon 100 is contained in sheath 220 before expansion
It is interior.
According to the difference of balloon catheter structure, there are following several embodiments, is described in detail by following embodiment:
Embodiment one
Referring to Figure 1 and Fig. 2, in drug coated balloon catheter provided in this embodiment, driving means 300 includes having one
Determine the push conduit 310 of axial length.A medicine-coated balloon 100 is fixed in the distal end of push conduit 310.Medicine-coated balloon
100 fixed form can be the technological means generally in the art such as welding or bonding, and details are not described herein.Medicine-coated balloon
It is contained in sheath 220 after 100 flaps and winding.The close end and distal portion of medicine-coated balloon 100 are taper, and middle part is
Substantial cylindrical active section.The length range of medicine-coated balloon 100 is 30-320mm.The diameter range of active section is 2-
15mm.Length (that is, effective length of the medicine-coated balloon 100) range of active section is 20-300mm.Effective length refers to
After balloon expandable, the length that can be attached on blood vessel.The diameter of medicine-coated balloon 100, effective length equidimension specification
The diseased region blood vessel diameter that can be expanded as needed is selected.
The surface of medicine-coated balloon 100 coats one layer of active medicine coating 30.Contain in active medicine coating 30 and has
Inhibit the active medicine (such as: taxol, rapamycin) of smooth muscle cell proliferation effect.Active medicine coating 30 is applied to
The prior art, details are not described herein.The cylindrical work section of medicine-coated balloon 100 can guarantee the medication coat ball after filling
Capsule 100 has good adherence quality, and effectively active medicine can be transferred on the blood vessel of diseased region.
At least one guidewire lumen 1 and at least one first full chamber 2 are axially set in push conduit 310.In the present embodiment,
Referring to Fig. 3, pushes in conduit 310 and be respectively equipped with one for accommodating and by the guidewire lumen 1 of seal wire (not shown go out) along axial direction
Being used to the inside of medicine-coated balloon 100 be passed through or extract out liquid with one keeps sacculus full or the first full chamber 2 of pressure release.
Guidewire lumen 1 axially through push conduit 310 proximally and distally.The inside of first full chamber 2 and medicine-coated balloon 100 connects
It is logical.
Referring again to Fig. 1, driving means 300 further includes the catheter block 320 set on push 310 proximal end of conduit.Catheter block
320 are equipped with guidewire port 15 and the first full port 16.Guidewire port 15 is connected to guidewire lumen 1.Guidewire lumen 1 and guidewire port 15
For accommodating and passing through seal wire.Sacculus is provided on the distal end tube body of push conduit 310 protruded into inside medicine-coated balloon 100 to fill
It is full of mouth 101.The proximal end and distal end of first full chamber 2 fill mouth 101 with the first full port 16 and sacculus respectively and are connected.By
This, the first full port 16, the first full chamber 2 and sacculus fill mouth 101 formed to medicine-coated balloon 100 carry out it is full or
The channel of pressure release.External pressure pump is connected by the first full port 16, pressure fluid is filled via the first full port 16, first
It is full of inside chamber 2 and the full entrance of mouth 101 of sacculus or outflow medicine-coated balloon 100, to realize filling for medicine-coated balloon 100
It is full of expansion or pressure release.
Push conduit 310 protrudes into the tube body inside medicine-coated balloon 100 and is equipped with development positioning device 111.Development is fixed
Position device 111 is made of radiopaque material, the positioning for medicine-coated balloon 100 in surgical procedure.Development positioning dress
111 are set to be preferably provided on push conduit 310 corresponding with the active section of medicine-coated balloon 100.Positioning device 111 of developing can
To hold, heat, be bonded, weld or press using the diversified forms such as cyclic annular, Filamentous, band-like perhaps dotted and by pressure
Technological means commonly used in the art is fixed on push conduit 310.
Referring to Figure 1 to Fig. 4, sheath 220 is actively set in the outside of medicine-coated balloon 100, to medication coat
The active medicine coating 30 on 100 surface of sacculus is protected.Sheath 220 can be along the axial movement of push conduit 310.Medication coat
Sacculus 100 is contained in sheath 220 before expansion.Sheath 220 is preferably tubular structure, after being sleeved on flap and winding
Outside medicine-coated balloon 100.Preferably, 220 internal diameter of sheath is than the flap before expansion and the medicine-coated balloon after winding
Big 0~the 0.10mm of outer diameter at 100 largest outside diameter.In order to be conducive to the sliding axially along push conduit 310 of sheath 220, protect
Set 220 is preferably made of lesser materials of coefficient of frictions such as e-PTFE, PTFE, FEP or PET.
Please referring also to fig. 4 to fig. 6, the distal end of sheath 220 are equipped with shrinking hood 210.The diameter of shrinking hood 210 by proximal end extremely
Distal end is gradually reduced, that is, is gradually collapsed to push conduit 310 and is covered 310 distal end of push conduit in the distal end of shrinking hood 210.It receives
Contracting cover 210 can be covered on the distal portion of sheath 220 or be connected with the distal end of sheath 220.Shrinking hood 210 is along being axially arranged at least
One expandable expansion joint 211.When expansion joint 211 is opened, medicine-coated balloon 100 distally exposes from sheath 220.Expansion joint
211 are preferably arranged to lacerable structure, that is, before expansion joint 211 is not opened, are at least partly connected between expansion joint 211, receive
The distal end of contracting cover 210 is only pierced by for pushing the distal end of conduit 310, and medicine-coated balloon 100 can not stretch out.It is applied as a result, in drug
In the transmission process of layer sacculus 100, sheath 220 can protect the medication coat 30 of 100 outer surface of medicine-coated balloon, reduce blood vessel
Interior blood washes away caused drug loss to its.After medicine-coated balloon 100 is delivered to diseased region, sheath 220 is withdrawn,
Expansion joint 211 is strutted by medicine-coated balloon 100 until tearing, and the distal openings diameter of shrinking hood 210 increases, so that being accommodated in
Medicine-coated balloon 100 in sheath 220 can be extended and exposed to disease from the distal end of sheath 220 and the distal end of shrinking hood 210
Become in the vascular environment at position, full expansion then carried out to medicine-coated balloon 100 again, active medicine coating 30 is from expansible
Sacculus outer surface discharges and is transferred to the blood vessel of diseased region.
Please referring also to Fig. 1 and Fig. 4, the proximal end of sheath 220 are additionally provided with the behaviour for being actively sheathed on push 310 proximal end of conduit
Make handle 230, for controlling the sliding axially along push conduit 310 of sheath 220.230 distal end of 220 proximal end of sheath and operation handle
Between can be connected directly, can also be indirectly connected by hollow tube, which is actively sleeved on push conduit
310 outside.In the transmission process of medicine-coated balloon 100, sheath 220 is sleeved on outside medicine-coated balloon 100, protects medicine
Object coating 30 is not washed away by blood.After reaching diseased region, operation handle 230 of proximally dropping back, so that sheath 220 is along axial direction
Proximally slide, be now placed in 220 distal end of sheath shrinking hood 210 open, 100 self-constriction cover 210 of medicine-coated balloon it is remote
Expose in end and the distal end of sheath 220.
It is understood that in other embodiments, the quantity of medicine-coated balloon 100 can also be it is multiple, so as to right
Multiple diseased regions are expanded simultaneously.Specifically, Fig. 7 is referred to, delivery device 300 includes a push conduit 310.Push conduit
The first medicine-coated balloon 110 and the second medicine-coated balloon 120 is fixedly installed in 310 distal ends respectively.First medicine-coated balloon
110 and the second mutual alignment between medicine-coated balloon 120 be not construed as limiting, both only need to be respectively positioned on 310 distal end of push conduit
?.Axial distance between first medicine-coated balloon 110 and the second medicine-coated balloon 120 can be zero, can also root
According to the spacing of diseased region, setting spaced apart.
Fig. 8 to Figure 10 is referred to, one accommodated and by seal wire is respectively provided with along axial direction in push conduit 310 and leads
Silk chamber 1, the first full chamber 2 and the first full chamber 2 '.First full chamber 2 and the first full chamber 2 ' respectively with the first medication coat ball
Capsule 110 is connected with the inner cavity of the second medicine-coated balloon 120.The chamber of guidewire lumen 1, the first full chamber 2 and the first full chamber 2 '
It is not connected to mutually between body.Pushing conduit 310 can be using integrally formed multi-lumen tube (as can be seen from figures 8 and 9) or by more
Tube body fits together (as shown in Figure 10).
In Fig. 8 and Fig. 9, using integrally formed multi-lumen tube as push conduit 310.It pushes in conduit 310 and is equipped with mutually
Guidewire lumen 1, the first full chamber 2 and the first full chamber 2 ' separated.The cross-sectional shape of multi-lumen tube is not construed as limiting, and only needs three function
Energy cavity is parallel to each other, is not connected to mutually.Guidewire lumen 1 is for installing seal wire, and therefore, guidewire lumen 1 needs cavity smooth and shape
Shape is mobile conducive to seal wire, and the shapes such as round or ellipse are selected in the cross section of usual guidewire lumen 1.First full chamber 2 and first fills
The cross-sectional shape of chamber 2 ' of being full of is not construed as limiting, and can be any shape, generally can according to the cross-sectional shape of push conduit 310 and
1 location and shape of guidewire lumen, arrangement have the first full chamber 2 and the first full chamber 2 ' of the maximum cross-section area in favor of drug painting
The quick full or pressure release of layer sacculus.
In Figure 10, two root canal bodies fit together to form push conduit 310.Push conduit 310 include outer tube and inner tube, two
Person is set with and is fixed together to form push conduit 310.The lumen of inner tube is as guidewire lumen 1.Space between inner tube and outer tube
And a lumen being arranged in outer tube is respectively as the first full chamber 2 and the first full chamber 2 '.It is understood that at other
In embodiment, push conduit 310 can also be set in together to form push conduit 310 using more root canal bodies.
The shape and diameter of first medicine-coated balloon 110 and the second medicine-coated balloon 120 can be identical, can also not
Together.First medicine-coated balloon 110 and the second medicine-coated balloon 120 be generally cylindrical in shape or it is spherical, diameter according to
Blood vessel diameter selection.It is understood that the setting of two medicine-coated balloons can not only carry out simultaneously for different lesions
Processing, meanwhile, after a medicine-coated balloon is filled wherein, which can also have the work of blocking blood flow
With avoiding the medication coat on another medicine-coated balloon surface from being washed away by blood flow.In this case, first full sacculus
On can be not provided with active medicine coating, to reduce the cost of instrument.
Referring again to Fig. 7, the proximal end for pushing conduit 310 is equipped with catheter block 320.Catheter block 320 be equipped with guidewire port 15,
First full port 16 and the first full port 16 '.Guidewire port 15 is connected with guidewire lumen 1.Seal wire is movably worn as a result,
In the channel that guidewire port 15 and guidewire lumen 1 are formed.Push being located in the first medicine-coated balloon 110 for conduit 310
It is provided with sacculus on tube body and fills mouth 101.Ball is provided on the tube body of push conduit 310 being located in the second medicine-coated balloon 120
Capsule fills mouth 101 '.The proximal end and distal end of first full chamber 2 fill mouth 101 with the first full port 16 and sacculus respectively and are connected
It is logical.The proximal end and distal end of first full chamber 2 ' fill mouth 101 ' with the first full port 16 ' and sacculus respectively and are connected.As a result,
First full port 16, the first full chamber 2 and sacculus fill mouth 101 formed to the first medicine-coated balloon 110 carry out it is full or
The channel of pressure release.First full port 16 ', the first full chamber 2 ' and sacculus fill mouth 101 ' and are formed to the second medicine-coated balloon
120 carry out full or pressure release channel.
Conduit 310 is pushed corresponding with the active section of the first medicine-coated balloon 110 and the second medicine-coated balloon 120
At least one development positioning device 111 is respectively equipped on tube body, in order to pass through display development positioning device in the case where instrument detects
111 position is to indicate balloon position.Development positioning device 111 can be made of radiopaque developing material, and be had
The structure types such as ring, filiform, band-like, dotted or sheet.Positioning device 111 of developing preferably uses the form of developing ring.
One or more can be respectively set in development positioning device 111.Develop positioning device 111 fixed form can for welding, bonding,
Hot pressing, the technological means generally in the art such as press, and details are not described herein.
Drug coated balloon catheter provided in this embodiment has at least the following advantages compared with prior art:
(1) slidable sheath has protective effect to the medication coat of balloon surface, can reduce the medicine in transmission process
Object loss late；
(2) it can avoid the drug to fall off to be washed away by blood to distal vessels, block blood vessel；
(3) due to reducing drug loss rate, the initial drugloading rate on medicinal balloon surface can also be reduced, the generation of body is mitigated
It thanks to burden, improves the safety of drug coated balloon catheter.
Embodiment two
Drug coated balloon catheter provided in this embodiment, the structure of the drug coated balloon catheter provided with embodiment one
Essentially identical, difference place is, in the present embodiment, two sacculus is arranged, and the distance between two sacculus are adjustable.
Specifically, referring to Figure 11, driving means 300 includes push conduit 310 and is actively sheathed on push conduit 310
Outside and can be along the axial sliding catheter 340 with push 310 relative motion of conduit.The distal end fixation of push conduit 310 is set
Set at least one medicine-coated balloon 100.The distal end of sliding catheter 340 is equipped at least one second sacculus 400.It is understood that
It is that in other embodiments, the quantity of sliding catheter 340 may be set according to actual conditions, it is generally preferable to be arranged 1-2, phase
The quantity of Ying Di, the second sacculus 400 of every 340 distal end of sliding catheter may be set to be one or more, it is generally preferable to
It is arranged 1-2.
Sheath 220 is actively sheathed on the outside of medicine-coated balloon 100 and the second sacculus 400, that is, medicine-coated balloon
100 and second sacculus 400 be contained in sheath 220 before expansion.The distal end of sheath 220 is equipped with shrinking hood.It is set in shrinking hood
Set at least one expansion joint.The structure of sheath 220 and the structure of the sheath 220 of embodiment one are essentially identical, and details are not described herein.
Please also refer to Figure 12, pushes and be respectively equipped with mutual disconnected guidewire lumen 1 along axial direction in conduit 310 and be used for medicine
Object coating sacculus 100 carries out full or pressure release the first full chamber 2.The proximal end for pushing conduit 310 is equipped with catheter block 320.
Edge is axially arranged with for carrying out full or pressure release the second full chamber 4 to the second sacculus 400 in sliding catheter 340.
Second full chamber 4 is connected with the inner cavity of the second sacculus 400.The cross-sectional shape of sliding catheter 340 and wear push therein
Conduit 310 is related, since push conduit 310 occupies larger space, the side of push conduit 310 is arranged in the second full chamber 4
Side space.Regulation handle 330 is equipped in 340 proximal end of sliding catheter.Regulation handle 330 is equipped with the second full port 17.Sliding is led
The second sacculus, which is provided with, on the tube body of pipe 340 being located in the second sacculus 400 fills mouth 103.The proximal end and distal end of second full chamber 4
Mouth 103 is filled with the second full port 17 and the second sacculus respectively to be connected.It is full to fill mouth 103, second for the second sacculus as a result,
Chamber 4 and the second full port 17, which are formed, carries out full and pressure release channel to the second sacculus 400.
Second sacculus 400 is weldingly fixed on sliding catheter 340.The structure and shape of second sacculus 400 can be with drugs
Coating sacculus 100 is identical to be can also be different.Second sacculus 400 can be common sacculus, be also possible at least partly surface coating
The medicine-coated balloon of medication coat.Second sacculus 400 is also used as sealing other than it can expand diseased region
Stifled sacculus, that is, after the second sacculus 400 is first filled and expanded, block blood vessel, medicine-coated balloon 100 is avoided to stretch from sheath 220
Active medicine coating 30 is washed away by blood after out.It is understood that the surface of the second sacculus 400 for blocking blood vessel is preferred
To be not provided with active medicine coating.
The size of medicine-coated balloon 100 and the second sacculus 400 does not limit specifically depending on the blood vessel diameter to be expanded
It is fixed.But in the second sacculus 400 for when blocking blood vessel, the diameter of the second sacculus 400 should be slightly larger than medicine-coated balloon 100
Diameter, enable the second sacculus 400 instrument enter diseased region it is full after, first expanded than medicine-coated balloon 100, to hinder
Clinopodium polycephalum avoids blood flow washing away to the active medicine coating 30 of 100 outer surface of medicine-coated balloon.
Since sliding catheter 340 and push conduit 310 are coaxially disposed, that is, the sliding catheter 340 of tubular structure actively covers
It is located at outside push conduit 310, it is possible to reduce the entire outer diameter of foley's tube saves space, is conducive to push, improves passability.
It can be clearance fit between push conduit 310 and sliding catheter 340 or be slidably matched.In order to reduce therebetween
Frictional force, push at least one of 310 outer surface of conduit and/or 340 inner surface of sliding catheter be preferably conducive to sliding
Smooth surface.The smooth surface can be and directly coat lubricant coating on the surface, such as coat in push 310 outer surface of conduit
The lubriation materials such as silicone, polyethylene pyrrole network alkanone.The smooth surface is also possible to that push is made using the low material of coefficient of friction
Conduit 310 or/and sliding catheter 340.
3 and Figure 14 referring to Figure 1 is equipped with locking mechanism 500 between sliding catheter 340 and push conduit 310.When push is led
Pipe 310 and sliding catheter 340 reach near diseased region simultaneously, by sliding catheter 340 of to distal end push or proximally dropping back,
After adjusting the distance between medicine-coated balloon 100 and the second sacculus 400, conduit can will be pushed by locking mechanism 500
Relative position between 310 and sliding catheter 340 is fixed, can be by the phase between medicine-coated balloon 100 and the second sacculus 400
Position is fixed.There are many embodiments for locking mechanism 500, are described as follows:
As shown in figure 13, be the first embodiment of locking mechanism 500: sliding catheter 340 is actively set in push
Outside conduit 310.Locking mechanism 500 includes the springy locking member being fixed on sliding catheter 340.It is held tightly after springy locking member rotation
Push conduit 310 locks the two.The specific structure of springy locking member are as follows: springy locking member includes being fixed on sliding catheter 340
On positioning pipe 510 and the handwheel 530 that is threadedly coupled with positioning pipe 510.Positioning pipe 510 is set with and is fixed on sliding catheter 340
Proximal end, and positioning pipe 510 compared with regulation handle 330 closer to the proximal end of sliding catheter 340.Positioning pipe 510 and push conduit 310
Between be equipped with cylindric, flexible resilient sleeve 520.It in a free state, can between resilient sleeve 520 and push conduit 310
It is slidably matched or clearance fit.Handwheel 530 is connected with the pressure end 540 in insertion positioning pipe 510.It, can by rotation hand wheel 530
It drives pressure end 540 mobile to the direction of resilient sleeve 520 and compresses resilient sleeve 520, resilient sleeve 520 deforms after being pressurized, and radially stretches
It opens up and axial shrinkage, holding pushes 310 outer surface of conduit, so that sliding catheter 340 and push conduit 310 be locked；Pass through
Handwheel 530 is reversely rotated, pressure end 540 is mobile to the direction far from resilient sleeve 520, and resilient sleeve 520 is no longer pressurized, and has elasticity
Resilient sleeve 520 affranchise state, release sliding catheter 340 and push the locking between conduit 310.It is understood that
In other embodiments, springy locking member can also be fixed on push conduit 310.Sliding is blocked after springy locking member rotation to lead
Pipe 340 locks it with push conduit 310.
As shown in figure 14, be second of embodiment of locking mechanism 500: locking mechanism 500 includes that setting is led in push
The first locking piece 51 on pipe 310 and the second locking piece 52 being arranged on sliding catheter 340, and the first locking piece 51 and second
It is detachably connected between locking piece 52.When the first locking piece 51 and the second locking piece 52 are in discrete state, conduit 310 is pushed
And axially opposed can be moved between sliding catheter 340, with adjust between medicine-coated balloon 100 and the second sacculus 400 away from
From.When the first locking piece 51 and the second locking piece 52 are in connection status, push between conduit 310 and sliding catheter 340 not
It axially opposed can move, the distance between medicine-coated balloon 100 and the second sacculus 400 are also fixed.Preferably, the first lock
Determine to be detachably connected as being threadedly coupled or be connected together between part 51 and the second locking piece 52.For being threadedly coupled, ask
Referring to Figure 14, the first locking piece 51 is fixed on push conduit 310, and the first locking piece 51 is equipped with external screw thread 55.Second locking piece
52 limits are fixed on sliding catheter 340, and internal screw thread 56 is arranged in the second locking piece 52.First locking piece 51 and the second locking piece 52
Between be detachably connected by screw thread.The limit fixation of second locking piece 52 refers to that the second locking piece 52 only can be in sliding catheter
It rotates, cannot be moved axially in situ on 340.
Figure 15 to Figure 19, which is shown, carries out vascular lesion position using drug coated balloon catheter provided in this embodiment
The process for the treatment of, specific as follows:
Step 1: referring to Figure 15, the distal portions of drug coated balloon catheter are transported to the lesion of blood vessel 900 first
Near position, and medicine-coated balloon 100 is directed at the first diseased region；
Step 2: referring to Figure 16, sheath 220 of proximally dropping back, the expansion joint in shrinking hood is opened, medicine-coated balloon
100 and second sacculus 400 be exposed in blood vessel 900 respectively.
Step 3: referring to Figure 17, sliding catheter 340 of proximally dropping back, so that the second sacculus 400 is directed at the second lesion
Position.
Step 4: referring to Figure 18, the second sacculus 400 is filled, the second sacculus 400 after filling is to the second lesion
The blood vessel at position is sufficiently expanded, while can block the blood flow of blood vessel.
Step 5: referring to Figure 19, medicine-coated balloon 100 is filled, to the after medicine-coated balloon 100 is full
The blood vessel of one diseased region is sufficiently expanded, and medication coat discharges and be transferred to vascular wall from 100 surface of medicine-coated balloon, is played
Drug effect.Pressure release can be carried out to medicine-coated balloon 100 and the second sacculus 400 respectively later, it is external to withdraw from patient, completes hand
Art.It is understood that the sequence of second step and third step can exchange, it is as long as two sacculus are exposed from sheath respectively
It can.
Drug coated balloon catheter provided in this embodiment has at least the following advantages compared with prior art:
(1) slidable sheath has protective effect to the medication coat of balloon surface, can reduce the medicine in transmission process
Object loss late；
(2) relative position between medicine-coated balloon and the second sacculus is adjustable, can better adapt to blood vessel
Multiple diseased regions；
(3) second sacculus can be used as closure sacculus, and the blood flow in temporary interruption blood vessel further avoids blood pair
The active medicine coating on medicine-coated balloon surface washes away, and reduces drug loss rate, improves drug and is transferred to from balloon surface
The dose and efficiency of vascular wall；
It (4), can be by locking mechanism by the second sacculus and medicine-coated balloon after the position for adjusting the second sacculus
The locking of the distance between conduit is conducive to user and carries out subsequent operation.
Embodiment three
The structure for the drug coated balloon catheter that drug coated balloon catheter provided in this embodiment and embodiment two provide
Essentially identical, difference place is, the positional relationship and embodiment two between the push conduit and sliding catheter of the present embodiment
It is different with the positional relationship of sliding catheter to push conduit.
Specifically, Figure 20 is referred to, drug coated balloon catheter further includes at least one sliding catheter 340, sliding catheter
340 axially opposed push conduits 310 move, and 340 distal end of sliding catheter is equipped at least one second sacculus 400.
In drug coated balloon catheter provided in this embodiment, push conduit 310 distal end be connected with medication coat ball
First push branch 312 of capsule 100 is connected.The distal end of sliding catheter 340 and the second push branch for being connected with the second sacculus 400
322 are connected.The mode of connection may be a fixed connection or be integrally formed.The axial direction of first push branch 312 and the second push point
Branch axial direction between angle α range be (0 °, 180 °], i.e., angle α be 0 ° of 180 ° >=α >.The angle setting of angle α is base
Angle between two branch vessels of human body is generally no greater than 180 °, in favor of the first push branch 312 and the second push point
Medicine-coated balloon 100 and the second sacculus 400 are sent into two branch vessels of bifurcated vessels by branch 322 respectively.Sliding catheter 340
Axially opposed push conduit 310 moves.The relative position between medicine-coated balloon 100 and the second sacculus 400 can be with as a result,
It adjusts, so that the use process of foley's tube is more flexible, it can be after the second sacculus 400 enters branch, according to the second sacculus
400 and diseased region position, then reasonably adjusted.
Positional relationship between push conduit 310 and sliding catheter 340 has following two: sliding catheter 340 is movably
It is arranged between the inside of push conduit 310, or push conduit 310 and sliding catheter 340 and is set side by side.
Figure 20 is referred to, sliding catheter 340 is movably arranged in the inside of push conduit 310, and pushes conduit 310
Distal end tube wall is equipped with through-hole 318.340 distal end of sliding catheter is pierced by from through-hole 318 to be connect with the second push branch 322.
Sliding catheter 340 can be axially moved along push conduit 310 as a result, drive the second push branch 322 mobile to distal end or proximal end,
The position of the second sacculus 400 is adjusted, the bifurcated vessels and bifurcated vessels to adapt to different structure different narrow locations.It can
With understanding, pushing can be locked between conduit 310 and sliding catheter 340 by locking mechanism, the tool of locking mechanism
Body structure and the structure of the locking mechanism 500 of embodiment two are essentially identical, and details are not described herein.
Sliding catheter 340 can also be set side by side with push conduit 310, be connected by locating part therebetween, so that two
It is mutually moved only in the axial direction without radial motion between person.There are many modes for locating part: for example, push conduit 310 and sliding catheter
340 can be installed in annular collar, to limit between the two move radially.For another example push conduit 310 and sliding catheter
340 can be sleeved on jointly in the position-limiting tube with certain length, limit between the two move radially.It is led to reduce sacculus
Pipe integral diameter, improves safety at enhancing push power, and pushing conduit 310 and the shape of sliding catheter 340 should complement each other to form
Completely, without the shape of corner angle, such as round or ellipse.
It is the cross-sectional view for pushing conduit 310, axially disposed at least one in sliding catheter 340 together referring to fig. 2 shown in 1
A second full chamber 4, the distal end of the second full chamber 4 are connected to the inside of second sacculus 400.
312 distal end of the first push branch is extended to along the guidewire lumen 1 being axially arranged in push conduit 310, is applied for drug
Layer sacculus 100 fills and the first full chamber 2 of pressure release extends at the medicine-coated balloon 100 of the first push branch 312.Sliding
Also along being axially arranged with the second guidewire lumen 3 and for the second sacculus 400 to be full and the second full chamber 4 of pressure release in conduit 340.The
Two guidewire lumens 3 extend to 322 distal end of the second push branch, and the second full chamber 4 extends to the second sacculus of the second push branch 322
At 400.Second guidewire lumen 3 and the second full chamber 4 are respectively independent.First full chamber 2 from push conduit 310 in along axial direction be located at
100 inner cavity of medicine-coated balloon of first push 312 distal end of branch is connected.Second full chamber 4 is out of sliding catheter 340 along axis
It is connected to 400 inner cavity of the second sacculus for being located at the second push 322 distal end of branch.
Push conduit 310 is externally provided with sheath 220.When medicine-coated balloon 100 and unexpanded the second sacculus 400, the two is same
When winding accommodating in jacket 220, i.e., sheath 220 simultaneously medicine-coated balloon 100 and the second sacculus 400 are protected together.
Other than a sheath 220 is arranged, as shown in figure 22, drug coated balloon catheter further includes the second sheath 240.The
Two sheaths 240 are actively sheathed on the outside of the second sacculus 400, and the second sheath 240 is along the axial movement of sliding catheter 310.
Second sacculus 400 is contained in the second sheath 240 before expansion.Sheath 220 is respectively independently arranged with the second sheath 240, wherein
Sheath 220 is sleeved on the outside of push conduit 310 and medicine-coated balloon 100.Second sheath 240 is sleeved on sliding catheter 340
With the outside of the second sacculus 400.Second sheath 240 and sliding catheter 340 are all sleeved in push conduit 310.Second sheath 240
Proximal end is connected with handle 260, for operating the recession of the second sheath 240.After instrument reaches bifurcated vessels, by medicine-coated balloon
100 are sent into the first branch vessel, and second sacculus 400 is sent into the second branch vessel by mobile sliding catheter 340, then divide
Not Hou Che sheath 220 and the second sheath 240, medicine-coated balloon 100 and the second sacculus 400 be exposed in vascular environment respectively,
Then expansion is filled to medicine-coated balloon 100 and the second sacculus 400 respectively, treats the first branch vessel and second branch's blood
Pipe.Remaining structure of sheath 220 and the second sheath 240 and the structure of the sheath 220 of embodiment one are essentially identical, no longer superfluous herein
It states.
The dimensions of medicine-coated balloon 100 and the second sacculus 400 is depending on the blood vessel diameter to be expanded, specifically not
It limits.The quantity of medicine-coated balloon 100 and the second sacculus 400 is at least one respectively.When being only arranged one, set respectively
It sets in the distal end of the first push branch 312 and the second push branch 322.When being arranged multiple, then each medicine-coated balloon 100
Between between each second sacculus 400 can close to or interval setting.Corresponding each medicine-coated balloon 100 and the second ball
Capsule 400 is respectively equipped with third and fills chamber 5 and the 4th full chamber 6, for full to the sacculus.Its structure and aforementioned third are full
Chamber 5 is identical with the 4th full 6 structure of chamber, and details are not described herein.
As shown in figs. 23-25, the proximal diameter of the active section of medicine-coated balloon 100 and/or the second sacculus 400, which is greater than, is somebody's turn to do
The diameter of the rest part of the active section of sacculus.The active section of sacculus refers to: being bonded in the blood vessels with blood vessel for expanding
The part of blood vessel.The reason of being arranged in this way is, when medicine-coated balloon 100 and the second sacculus 400 are pushed respectively to bifurcated blood
After in two branch vessels of pipe, the active section proximal end of medicine-coated balloon 100 and the second sacculus 400 is located at bifurcated vessels simultaneously
Bifurcation site, and the blood vessel diameter of the bifurcation site is certainly less than the sum of two branch vessel diameters.Therefore in order to avoid being located at
The active section proximal end of the medicine-coated balloon 100 of bifurcation site and the active section proximal end of the second sacculus 400 cause after filling simultaneously
The vascular tear of bifurcation site, the sum of 400 active section proximal diameter of 100 active section proximal end of medicine-coated balloon and the second sacculus need
Less than the sum of 400 active section rest part diameter of medicine-coated balloon 100 and the second sacculus.
Meanwhile for sacculus, the length of active section is the effective length of sacculus, determines expansion of the sacculus to blood vessel
Open curative properties.The proximal diameter of the active section of second sacculus 400 of the present embodiment is less than its remaining part of the active section of the sacculus
Divide diameter, but compared with common taper sacculus, the second sacculus 400 still has longer effective length, therefore full
Afterwards, higher to the expanding ability of the vascular wall of branch vessel.In addition to the second sacculus 400 active section proximal diameter less than second
Outside the rest part diameter of the active section of sacculus 400, it can also be that the proximal diameter of the active section of medicine-coated balloon 100 is less than
The rest part diameter of the active section of medicine-coated balloon 100.Or 400 two balls of medicine-coated balloon 100 and the second sacculus
The proximal diameter of the active section of capsule is all respectively smaller than the rest part diameter of the active section of the two sacculus.
Medicine-coated balloon 100 close to proximal end part or/and the second sacculus 400 close to the part of proximal end diameter by remote
End to proximal end is gradually reduced.As a result, after medicine-coated balloon 100 and the second sacculus 400 full simultaneously, it can further prevent point
The vascular tear that vent is set.Refer to Figure 23, the close end and distal portion of medicine-coated balloon 100 be pyramidal structure 116, in
Portion is cylindrical active section 115.Second sacculus 400 generally taper, i.e. proximal diameter is small, the big taper of distal diameter.Please
Referring to fig. 24, the proximal end 123 and distal end 121 of the second sacculus 400 are taper, and middle part 122 is cylinder, between cylindrical and taper
Smooth transition.Figure 25 is referred to, 400 proximal end 123 of the second sacculus and distal end 121 are taper, and 122 part of middle part is cylinder, circle
Diameter is differently formed hierarchic structure between cylindricality and taper.The pyramidal structure of second sacculus, 400 proximal end 121, generally long taper,
That is taper variation is small, forms the taper that a segment length is longer, diameter change is small, and the part conic diameter is relative to cylindrical portion
Divide much smaller.Taper, long pyramidal structure can increase the spacing between medicine-coated balloon 100 and the second sacculus 400, avoid filling
It is full of the latter two fittings or spacing is small causes, blood vessel dilatation transition, vascular tear or forms interlayer.
The surface coating of second sacculus 400 can also be equipped with active medicine coating.Active medicine coating is mainly disposed to justify
The outer surface of cylindricality active section.Second sacculus 400 can also be not provided with active medicine coating.
As shown in figure 22, push 310 proximal end of conduit is equipped with catheter block 320.Catheter block 320 is equipped with the seal wire for installing seal wire
Port 15 fills the first full port 16 that chamber 5 is connected to third.First push branch 312 is located at medicine-coated balloon 100
The first full mouth 101 is provided on interior tube body.First full mouth 101, third fill chamber 5 and the first full formation pair of port 16
Medicine-coated balloon 100 carries out full and pressure release channel.
340 proximal end of sliding catheter is equipped with regulation handle 330.Regulation handle 330 is equipped with the second seal wire end for installing seal wire
Mouth 18, the second full port 17 being connected to the 4th full chamber 6.The pipe of second push branch 322 being located in the second sacculus 400
The second full mouth 102 is provided on body.Second full mouth 102, the 4th full chamber 6 and the second full port 17 are formed to the second ball
Capsule 400 carries out full and pressure release channel.
The drug coated balloon catheter of the present embodiment has at least the following advantages compared with prior art:
(1) slidable sheath has protective effect to the medication coat of balloon surface, can reduce the medicine in transmission process
Object loss late；
(2) relative position between medicine-coated balloon and the second sacculus is adjustable, can better adapt to bifurcated blood
Multiple branch vessels of pipe and different lesions position；
(3) second sacculus can be set to irregular shape, avoid the blood vessel of tearing bifurcation site；
It (4), can be by locking mechanism by the second sacculus and medicine-coated balloon after the position for adjusting the second sacculus
Relative position locking between conduit, is conducive to user and carries out next step operation.
To sum up, drug coated balloon catheter of the invention passes through the slidable shield of external setting in medicine-coated balloon
Set, avoids blood flow and washes away to medication coat, so that the drug loss rate being effectively reduced in transmission process, improves drug and apply
The validity of layer sacculus；It can avoid the drug to fall off simultaneously to be washed away by blood to distal vessels, block blood vessel；Further, since drop
Low drug loss rate, can also reduce the initial drugloading rate on medicinal balloon surface, mitigate the metabolic burden of body, improve drug
The safety of coating sacculus.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (16)
1. a kind of drug coated balloon catheter, including with the push conduit of certain axial length and at least one be set to described push away
The medicine-coated balloon of distal end of catheter is sent, the medicine-coated balloon includes expandable balloon and can at least partly expand described in covering
Open the active medicine coating of balloon surface, it is characterised in that: the drug coated balloon catheter further includes actively being sheathed on institute
The sheath outside medicine-coated balloon is stated, and the sheath is along the axial movement of the push conduit, the medicine-coated balloon
It is contained in front of expansion in the sheath.
2. drug coated balloon catheter according to claim 1, which is characterized in that the distal end of the sheath, which is equipped with, shrinks
The push distal end of catheter is gradually collapsed to the push conduit and covered in cover, the shrinking hood distal end, and the shrinking hood is along axis
To equipped at least one expandable expansion joint.
3. drug coated balloon catheter according to claim 1, which is characterized in that the internal diameter of the sheath is than the drug
Outer diameter big 0~0.10mm of the coating sacculus at the largest outside diameter before expansion.
4. drug coated balloon catheter according to claim 1, which is characterized in that it is described push lead inner axial tube be arranged to
A few guidewire lumen and at least one first full chamber, the guidewire lumen axially through the push conduit proximal end and distal end,
The first full chamber is connected to the inside of the medicine-coated balloon.
5. drug coated balloon catheter according to claim 4, which is characterized in that the drug coated balloon catheter also wraps
The catheter block for being set to the push catheter proximal end is included, the catheter block is equipped with guidewire port and at least one first full port,
The guidewire port is connected with the guidewire lumen, and the first full port is connected with the described first full chamber.
6. drug coated balloon catheter according to claim 1, which is characterized in that the drug coated balloon catheter also wraps
The operation handle for being actively sheathed on the push catheter proximal end is included, the distal end of the operation handle and the proximal end of the sheath are straight
It connects or is indirectly connected with by hollow tube in succession.
7. drug coated balloon catheter according to claim 1, which is characterized in that the drug coated balloon catheter also wraps
At least one sliding catheter, the axially opposed push catheter movement of sliding catheter are included, the sliding catheter distal end is set
There are at least one second sacculus, at least one axially disposed second full chamber in the sliding catheter, the second full chamber
Distal end be connected to the inside of second sacculus.
8. drug coated balloon catheter according to claim 7, which is characterized in that second sacculus is accommodated before expansion
In in the sheath.
9. drug coated balloon catheter according to claim 7, which is characterized in that the drug coated balloon catheter also wraps
The second sheath is included, second sheath is actively sheathed on the outside of second sacculus, and second sheath is along the cunning
The axial movement of dynamic conduit, second sacculus are contained in second sheath before expansion.
10. drug coated balloon catheter according to claim 7, which is characterized in that second sacculus is at least partly
Surface coated medicament coating.
11. drug coated balloon catheter according to claim 7, which is characterized in that the sliding catheter is actively arranged
In the outside for pushing conduit or it is arranged in the inside for pushing conduit；Or the sliding catheter is led with the push
The setting of pipe parallel arranged.
12. drug coated balloon catheter according to claim 11, which is characterized in that the sliding catheter and the push
It is limited and is connected by locating part between conduit, so that the sliding catheter and the push conduit only axially opposed movement.
13. drug coated balloon catheter according to claim 7, which is characterized in that the medicine-coated balloon and/or institute
State the active section of the second sacculus proximal diameter be greater than the sacculus active section rest part diameter.
14. drug coated balloon catheter according to claim 7, which is characterized in that the medicine-coated balloon expansion is led
Pipe further includes the locking mechanism between the sliding catheter and the push conduit.
15. drug coated balloon catheter according to claim 14, which is characterized in that the locking mechanism includes being fixed on
Springy locking member on the sliding catheter holds the push conduit tightly after the springy locking member rotation and locks the two；
Or the locking mechanism includes being fixed on the supravasal springy locking member of push, after the springy locking member rotation
The sliding catheter is blocked to lock the two.
16. drug coated balloon catheter according to claim 14, which is characterized in that the locking mechanism includes that setting exists
Supravasal first locking piece of the push and the second locking piece being arranged on the sliding catheter, first locking piece with
It is detachably connected between second locking piece, when first locking piece is connect with second locking piece, the push is led
It is fixed between pipe and the sliding catheter, it is described when dismantling connectionless between first locking piece and second locking piece
Push axially opposed movement between conduit and the sliding catheter.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710653108.4A CN109381783B (en) | 2017-08-02 | 2017-08-02 | Drug coated balloon catheter |
| PCT/CN2018/096902 WO2019024726A1 (en) | 2017-08-02 | 2018-07-24 | Balloon catheter with drug coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710653108.4A CN109381783B (en) | 2017-08-02 | 2017-08-02 | Drug coated balloon catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109381783A true CN109381783A (en) | 2019-02-26 |
| CN109381783B CN109381783B (en) | 2024-07-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710653108.4A Active CN109381783B (en) | 2017-08-02 | 2017-08-02 | Drug coated balloon catheter |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109381783B (en) |
| WO (1) | WO2019024726A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111760163A (en) * | 2020-06-23 | 2020-10-13 | 上海市东方医院（同济大学附属东方医院） | Uterine balloon catheter and medical assembly |
| CN113648023A (en) * | 2021-07-05 | 2021-11-16 | 科凯(南通)生命科学有限公司 | Repairing saccule for treating thrombus and calcified lesion |
| CN114712672A (en) * | 2022-04-14 | 2022-07-08 | 四川大学华西医院 | Medicine-carrying balloon catheter |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730246B (en) * | 2017-01-16 | 2019-08-09 | 杭州唯强医疗科技有限公司 | It is suitble to the adjustable bent catheter of left-handed operation |
| WO2020200184A1 (en) * | 2019-04-01 | 2020-10-08 | Vascuros Medical (Shanghai) Co., Ltd | A method for removing free floating non-therapeutic drug particles released from a drug coated balloon catheter |
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| CN111760163A (en) * | 2020-06-23 | 2020-10-13 | 上海市东方医院（同济大学附属东方医院） | Uterine balloon catheter and medical assembly |
| CN113648023A (en) * | 2021-07-05 | 2021-11-16 | 科凯(南通)生命科学有限公司 | Repairing saccule for treating thrombus and calcified lesion |
| CN114712672A (en) * | 2022-04-14 | 2022-07-08 | 四川大学华西医院 | Medicine-carrying balloon catheter |
| CN114712672B (en) * | 2022-04-14 | 2023-07-18 | 四川大学华西医院 | Medicine carrying balloon catheter |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019024726A1 (en) | 2019-02-07 |
| CN109381783B (en) | 2024-07-26 |
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