CN1093710A - Theapolyhenol germanium and preparation method thereof - Google Patents
Theapolyhenol germanium and preparation method thereof Download PDFInfo
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- CN1093710A CN1093710A CN 93104475 CN93104475A CN1093710A CN 1093710 A CN1093710 A CN 1093710A CN 93104475 CN93104475 CN 93104475 CN 93104475 A CN93104475 A CN 93104475A CN 1093710 A CN1093710 A CN 1093710A
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- germanium
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- polyphenol
- theapolyhenol
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Abstract
Theapolyhenol germanium and preparation method thereof
The invention relates to the novel substance of synthetic---the preparation method of Theapolyhenol germanium and Theapolyhenol germanium, Theapolyhenol germanium is the organometallics of germanium, mainly comprises racemization (C
15H
12O
6)
2Ge, left-handed (C
15H
12O
6)
2Ge, racemization (C
15H
13O
7)
2Ge, left-handed (C
15H
13O
7)
2Ge, left-handed (C
22H
16O
10)
2Ge, left-handed (C
22H
16O
11)
2Ge, six kinds of compounds.The direct combination reaction of tea-polyphenol and germanic forms Theapolyhenol germanium, and speed of response is fast.
Theapolyhenol germanium has the function of tea-polyphenol and organic germanium probably concurrently, promptly has to eliminate biological free radical, anticancer swollen, radioprotective and nourishing function.
Description
The present invention is a kind of organometallic compound of germanium of synthetic.
This compound is retrieved 1960-1993 U.S. chemical abstract index through the contriver, do not detect the document of Theapolyhenol germanium, through Guizhou Province institute of scientific-technical information Theapolyhenol germanium (Tea polyphenol gramanium) is carried out foreign patent and U.S.'s digest online information retrieval again, also find no the document (seeing Appendix) of this material, so Theapolyhenol germanium is a kind of new material that the contriver invents.
Tea-polyphenol by some polyphenolic compounds as: catechin, flavones, cyanine, phenolic acid are formed, and wherein the content of catechin generally accounts for about 70% of polyphenol total amount, and high reaches 80%.
According to the pertinent data introduction, tea-polyphenol has the biological free radical of removing, anticancer swollen, radiation-resistant function, germanium is one of composition of many medicinal plants, genseng and some other medicinal plant have unique nourishing function, wherein high-load germanium plays an important role, and other organic compound of germanium also has antitumour activity.Purpose of the present invention, be to develop a kind of antitumour activity function of existing tea-polyphenol, the tonic effect that organic germanium is arranged again, both can make medicine, also can make a kind of material of protective foods additive, and Theapolyhenol germanium had both contained tea-polyphenol, was again the organic compound of germanium, and expection can achieve the above object.
The present invention proposes the artificial synthesis of Theapolyhenol germanium.
The method principle is by extracting tea-polyphenol in the tealeaves, then with the germanic direct reaction, generates Theapolyhenol germanium, and speed of response is fast, and tea-polyphenol and germanic are pressed the equivalent batching during batching, and productive rate reaches about 98%.
According to the pertinent data introduction, mainly contain tea catechin by the tea-polyphenol that obtains in the tealeaves, content is more six kinds of compounds:
(1) racemization catechin (english abbreviation DL-C)
(2) left-handed l-Epicatechol (english abbreviation L-EC)
(3) racemization l-Epigallocatechol (english abbreviation DL-GC)
(4) left-handed epigallocatechin (english abbreviation L-EGC)
(5) left-handed L-Epicatechin gallate (english abbreviation L-ECG)
(6) left-handed NVP-XAA 723 (english abbreviation L-EGCG)
Wherein L-EGCG accounts for 56%, DL-GC, and L-EGC, the total amount of L-ECG and LEGCG accounts for 90.2%.
The Theapolyhenol germanium reaction formula that tea-polyphenol and germanic generate is representative with the catechin, and the group of R1, R2 representative in the reaction formula is indicated after following table "=" number.
Several main catechins and germanic reaction product table look-up in the tea-polyphenol
The Theapolyhenol germanium of synthetic is a kind of mixture, is the yellow solid powder, soluble in water and 95% ethanol, and dissolving is less in ethyl acetate.Wherein sequence number 3-6 is a main body, and especially sequence number 6 content are the highest, and Theapolyhenol germanium preparation method step is as follows:
1,, from tealeaves, extracts tea-polyphenol according to pertinent data;
2, tea-polyphenol and the abundant mixing of germanic are produced chemical reaction, question response generates till the Theapolyhenol germanium fully;
3, the tea-polyphenol that generates is separated with impurity;
4, with the washing of isolated Theapolyhenol germanium, dehydration, oven dry and finished product.
Embodiment:
A, feedstock production:
(1) extracts tea-polyphenol according to pertinent data with fragment green tea;
(2) get pure germanium dioxide 5 grams, add pure cerium hydroxide sodium 5 grams, 150 milliliters of adding distil waters, heating for dissolving.Filtrate is neutralized to subacidity with 1: 1 hydrochloric acid, with distilled water diluting to 600 milliliter.
The preparation of B, Theapolyhenol germanium
(1) gets tea-polyphenol 50 grams,, under agitation slowly add germanic solution, until adding, till reacting completely with 200 liters of dissolved in distilled water.
(2) add salt and saltout, Theapolyhenol germanium is separated out by solution.
(3) filtering separation, washing, dehydration, vacuum-drying.
(4) productive rate: product weight 54 grams, productive rate 98%.
C, Theapolyhenol germanium analysis
Use fractionation by distillation, phenylfluorone colour developing, the germanium in the spectrophotometry product; Use the titration of potassium permanganate tea-polyphenol, two kinds of method measurement results are identical, and product contains Theapolyhenol germanium 98%.
" pertinent data " of the present invention comprising:
1, " Japanese farming rue chemistry can will " 59 volumes, 2 phases, 129-134 page or leaf.Chen Ruifeng etc. translate;
" Food science ", 11 phases, 46-50 page or leaf, 1988
2, Luo Chenggang: " Food science " 9 phases, 17-20 page or leaf, nineteen ninety
3, Bai Mingzhang etc.: " chemistry circular " No11,23-28(1987)
Claims (7)
1, a kind of material that forms by tea-polyphenol and germanic chemical combination.It is characterized in that its chemical constitution is a Theapolyhenol germanium.
2, a kind of preparation method of the material that is formed by tea-polyphenol and germanic chemical combination is characterized in that tea-polyphenol and germanic direct reaction are formed.
3, the material that is formed by tea-polyphenol and germanic chemical combination according to claim 1 is characterized in that Theapolyhenol germanium mainly is to contain catechin germanium, comprises the i.e. (C of DL-C Ge
15H
12O
6)
2Ge, DL-EC Ge i.e. (C
15H
12O
6)
2Ge, L-EGC Ge i.e. (C
15H
13O
7)
2Ge, L-ECG Ge i.e. (C
22H
16O
10)
2Ge, L-EGCG Ge i.e. (C
22H
16O
11)
2Ge, DL-GC Ge i.e. (C
15H
13O
7)
2Ge.
4, the material that is formed by tea-polyphenol and germanic chemical combination according to claim 3 is characterized in that in the catechin germanium, again with DL-GC, and Gz, L-EGC Ge, L-ECG Ge and L-EGCGGe are main body.
5, the material that is formed by tea-polyphenol and germanic chemical combination according to claim 3 is characterized in that in the catechin germanium, and is the highest with L-EGCG content.
6, the preparation method of the material that is formed by tea-polyphenol and germanic chemical combination according to claim 2 is characterized in that tea-polyphenol and germanic are made the aqueous solution, and both are mixed, and through saltouing, filters, washing, dehydration, and vacuum-drying forms.
7, according to the preparation method of claim 2, the 6 described materials that form by tea-polyphenol and germanic chemical combination, it is characterized in that tea-polyphenol and germanic are to prepare burden by chemical equivalent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93104475 CN1044477C (en) | 1993-04-15 | 1993-04-15 | Theapolyhenol germanium and its preparation method. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93104475 CN1044477C (en) | 1993-04-15 | 1993-04-15 | Theapolyhenol germanium and its preparation method. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1093710A true CN1093710A (en) | 1994-10-19 |
| CN1044477C CN1044477C (en) | 1999-08-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93104475 Expired - Fee Related CN1044477C (en) | 1993-04-15 | 1993-04-15 | Theapolyhenol germanium and its preparation method. |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1044477C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039230C (en) * | 1995-03-20 | 1998-07-22 | 中国科学院长春应用化学研究所 | Synthesis of water-soluble bis-organo-substituted germanium compounds |
| CN102617632A (en) * | 2012-03-08 | 2012-08-01 | 暨南大学 | Organic germanium complex, and preparation method and application thereof |
-
1993
- 1993-04-15 CN CN 93104475 patent/CN1044477C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039230C (en) * | 1995-03-20 | 1998-07-22 | 中国科学院长春应用化学研究所 | Synthesis of water-soluble bis-organo-substituted germanium compounds |
| CN102617632A (en) * | 2012-03-08 | 2012-08-01 | 暨南大学 | Organic germanium complex, and preparation method and application thereof |
| CN102617632B (en) * | 2012-03-08 | 2014-11-12 | 暨南大学 | Organic germanium complex, and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1044477C (en) | 1999-08-04 |
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