CN109365128A - Magnetic particle field flow separator and method based on rotating excitation field - Google Patents
Magnetic particle field flow separator and method based on rotating excitation field Download PDFInfo
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- CN109365128A CN109365128A CN201811327163.5A CN201811327163A CN109365128A CN 109365128 A CN109365128 A CN 109365128A CN 201811327163 A CN201811327163 A CN 201811327163A CN 109365128 A CN109365128 A CN 109365128A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/32—Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
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Abstract
The invention discloses a kind of magnetic particle field flow separator and method based on rotating excitation field, described device includes three-phase windings；Three-phase windings include the first phase winding, the second phase winding and third phase winding；First phase winding, the second phase winding and third phase winding Astrocytic conditioned medium and using the axis of pedestal as axial symmetry be arranged on the base；The head end of first phase winding, the second phase winding and third phase winding is connected to the output end of three phase mains respectively, and the output electric current of three phase mains is symmetrical three phase sine alternating current；Pedestal is in hollow structure, is equipped with split tunnel in enclosed space.The present invention is placed in split tunnel in the inner cylindrical space that three-phase windings and pedestal are formed, and adjusts the three-phase voltage size and frequency that are added on three-phase windings by frequency converter.The frequency that control magnetic particle is acted on by rotating excitation field, changes the size of split tunnel magnetic induction intensity, realizes and separates to the field flow of different-grain diameter or the identical magnetic susceptibility difference magnetic particle of diameter grain.
Description
Technical field
The present invention relates to magnetic particle Analyze & separate field, specifically a kind of magnetic particles subfield based on rotating excitation field
Flow splitting device and method.
Background technique
Magnetic particle has wide answer in fields such as magnetic and medicated manufacture, magnetic resonance imaging, magnetic thermotherapy and cell screenings
With prospect, the research of magnetic particle and microballoon has greatly pushed the development of biological medicine.
Magnetic particle is in application process, it is desirable that it is with good monodispersity.The monodispersity of magnetic particle refers to
The uniformity of partial size and the uniformity of magnetic susceptibility.It is still difficult to obtain list by the optimization of process conditions in magnetic particle preparation process
The magnetic particle of good dispersion just becomes the weight for improving its monodispersity to the magnetic particle further progress separation screening of preparation
Want means.
Currently, the magnetic particle separation method based on magnetic field mainly includes magnetophoresis Magnetic Isolation method, magnetic catch and releases
The Magnetic Isolation method and magnetic field flow separation method put.Magnetophoresis is that its motion profile is sent out under magnetic fields using magnetic particle
Changing or deviation, to reach the separation of particle.Magnetic Isolation method based on magnetophoresis, the basic principle is that partial size it is different or
Magnetic field force suffered by the different magnetic particle of saturated magnetization rate is of different sizes, and magnetophoresis speed is also different.Particle can be in separation
Different location in channel, if outlet end is divided into several channels side by side, different particles will be from different outlet streams
Out.When magnetic catch and the separation method of release are that magnetic particle passes through near magnetic pole under current-carrying drive, there is magnetic responsiveness
Sample be greater than viscosity resistance by magnetic field force, particle is attracted near magnetic pole, is retained in magnetic field, referred to as " capture "；When
When increasing rate of Carrier Stream or reducing magnetic induction intensity, the weak magnetic particle institute of magnetic responsiveness is magnetic field force induced to be less than viscosity resistance, grain
Son flows out magnetic field under the drive of viscosity resistance and is eluted out, referred to as " discharges ".The separation method benefit of magnetic field capture and release
Reservation with magnetic field to magnetic particle, by adjusting magnetic field strength, the particle for selectively making magnetism weak flows out and magnetism is strong
Particle retain.Magnetic field flow separation method is to utilize magnetic particle magnetic responsiveness and suffered gravity using magnetic field as impressed field
Comprehensive function make particle in split tunnel enter different laminar flows, in the liquid stream phase of parabola flow pattern, channel center is attached
Close flow velocity is big, and the flow velocity close to flow path wall is smaller, and the magnetic particle in different fluid layers obtains different flow velocitys and realizes
Separation.
Mainly there are stationary magnetic field and rotating excitation field in magnetic field used in magnetic field flow separation method.If externally-applied magnetic field is static
Magnetic field, sphere of action is limited, limits magnetic field to the migration range of particle, restricts the length of split tunnel, make to separate
Degree reduces.Irreversible Adsorption caused by stationary magnetic field and particle magnetic coagulation will lead to serious peak area broadening.With stationary magnetic field
It compares, rotating excitation field improves the separating effect of magnetic particle, has certain advantage.Periodic rotating excitation field extends
The sphere of action in magnetic field convenient for extending split tunnel, and keeps the adjusting in magnetic field easier.Rotating excitation field can eliminate magnetic field
Irreversible capture, inhibit particle aggregation.Existing rotating excitation field is to be fixed on permanent magnet and joining turn of motor
On axis, magnet is under the drive of motor right above split tunnel or underface is made periodic circumference along channel and transported
Dynamic, the rotation direction of magnet is identical as current-carrying direction.This rotating excitation field changes magnetic field to separation by adjusting motor speed
The acting frequency of magnetic particle, precision be not high in channel.Change the magnetic induction intensity in split tunnel, needs to adjust magnet and divide
With a distance from channel, and to guarantee the depth of parallelism of magnet rotary motion track and split tunnel, implement relatively difficult.
Summary of the invention
According to technical problem set forth above, and provide a kind of magnetic particle field flow separator based on rotating excitation field and
Method.The technological means that the present invention uses is as follows:
A kind of magnetic particle field flow separator based on rotating excitation field, including three-phase windings；
The three-phase windings include the first phase winding, the second phase winding and third phase winding；
First phase winding, second phase winding and the third phase winding Astrocytic conditioned medium and with the axis of pedestal it is
Axial symmetry is arranged on the pedestal；
The head end of first phase winding, second phase winding and the third phase winding is defeated with three phase mains respectively
Outlet connection, the output electric current of the three phase mains are symmetrical three phase sine alternating current；
The pedestal is in hollow structure, is equipped with split tunnel in enclosed space；
The input terminal of the split tunnel is connected to sampling injector and infusion pump respectively by triple valve.
The three phase mains obtains in the following manner:
Three-phase alternating voltage or single-phase AC voltage (frequency 50Hz) are become after the rectifier rectification in frequency converter
DC voltage becomes the three-phase alternating current with certain frequency and voltage using the inverter in frequency converter.
It is realized with the frequency converter and the frequency of rotating excitation field and the voltage swing of three-phase windings is adjusted.
The three phase mains is input to the electric current of first phase winding, second phase winding and the third phase winding
Respectively iU、iV、iW, and iU、iV、iWMeet following formula:
The head end of first phase winding, second phase winding and the third phase winding exports three with frequency converter respectively
When the output end connection of phase voltage, just there is symmetrical three phase sine alternating current i in three-phase windingsU、iV、iWIt flows through, they are produced
Raw resultant magnetic field is constantly rotating with the variation of electric current in winding space, forms rotating excitation field.
The split tunnel is microcapillary or flat channel.
The rotating excitation field generated using three-phase windings makes magnetic particle in the liquid phase in the split tunnel as impressed field
Reach separating effect in laminar flow.
The magnetic field flow separation system constructed using rotating excitation field, fluid velocity, rotating excitation field frequency and magnetic induction intensity
Etc. factors can all influence the reservation and separation of magnetic particle.
When the frequency of rotating excitation field is higher, magnetic particle can carry out magnetophoresis on current-carrying direction.
The length of the microcapillary is meter level, internal diameter is micron order and in the shape of a spiral, and designing spiral is to increase
The length of the split tunnel in the pedestal enclosed space.
The inner wall of the pedestal is equipped with plastic cylinder cylinder, and the inner wall of the plastic cylinder cylinder is equipped with described fine for being embedded in
The helicla flute of pipe.
The output end of the split tunnel is connected to by ultraviolet-visible detector with waste collection bottle.Ultraviolet-visible light
Detector is used to detect the separation situation of magnetic particle, and waste collection bottle can collect the liquid stream flowed out from split tunnel.
The invention also discloses a kind of magnetic particle field flow separator according to described above based on rotating excitation field into
The method of row magnetic particle field flow separation, has following steps:
S1, the three phase mains are distinguished defeated to first phase winding, second phase winding and the third phase winding
Enter electric current iU、iV、iW, rotating excitation field is formed in the pedestal enclosed space, and the rotary magnetic is adjusted by the frequency converter
Voltage swing in the frequency and three-phase windings of field；
S2, in the case where the plastic cylinder barrel thickness is constant, pass through the inner diameter for changing the plastic cylinder cylinder
And outer diameter, the radial position of the microcapillary is adjusted, the induction level of the split tunnel position is changed；
S3, the magnetic particle for the different magnetic susceptibility injected through the sampling injector and the flowing that is pumped into through the infusion pump
The split tunnel is mutually entered from the input terminal of the split tunnel by the triple valve, carries out the separation of magnetic particle field flow.
The split tunnel is microcapillary or flat channel.
The length of the microcapillary is meter level, internal diameter is micron order and in the shape of a spiral；
The inner wall of the pedestal is equipped with plastic cylinder cylinder, and the inner wall of the plastic cylinder cylinder is equipped with described fine for being embedded in
The helicla flute of pipe.
The present invention provide it is a kind of with three-phase windings generate rotating excitation field as magnetic field flow separation in impressed field progress
The device and method of magnetic particle separation are placed in split tunnel in the inner cylindrical space that three-phase windings and pedestal are formed,
The three-phase voltage size and frequency that are added on three-phase windings are adjusted by frequency converter.Control magnetic particle is acted on by rotating excitation field
Frequency changes the size of split tunnel magnetic induction intensity, realizes to different-grain diameter or the identical magnetic susceptibility difference magnetic particles of diameter grain
The field flow separation of son.
The present invention can be widely popularized in fields such as magnetic particle separation based on the above reasons.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to do simply to introduce, it should be apparent that, the accompanying drawings in the following description is this hair
Bright some embodiments for those of ordinary skill in the art without any creative labor, can be with
It obtains other drawings based on these drawings.
Fig. 1 is three-phase windings and pedestal connection schematic diagram in a specific embodiment of the invention.
1. pedestal in figure；2. three-phase windings.
Fig. 2 is the first phase winding in a specific embodiment of the invention, the second phase winding and third phase winding Astrocytic conditioned medium
Schematic diagram.
Fig. 3 is the waveform diagram of symmetrical three phase sine alternating current in a specific embodiment of the invention.
Fig. 4 is the signal for the resultant magnetic field that the three-phase current in a specific embodiment of the invention in three-phase windings generates
Figure, wherein (a) ω t=0 °, (b) ω t=60 °, (c) ω t=120 °
Fig. 5 is that the structure of the magnetic particle field flow separator in a specific embodiment of the invention based on rotating excitation field is shown
It is intended to.
1. pedestal in figure；2. three-phase windings；3. microcapillary；4. plastic cylinder cylinder；5. frequency converter；6. triple valve；7. infusion
Pump；8. sampling injector；9. ultraviolet-visible detector；10. waste collection bottle.
Fig. 6 is microcapillary and plastic cylinder cylinder connection schematic diagram in a specific embodiment of the invention.
Fig. 7 is that saturation induction density is respectively 2.32emu/g and 3.50emu/g in a specific embodiment of the invention
Magnetic particle separating effect figure.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
Embodiment 1
As shown in figs 1 to 6, a kind of magnetic particle field flow separator based on rotating excitation field, including three-phase windings 2；
The three-phase windings 2 include the first phase winding, the second phase winding and third phase winding；
First phase winding, second phase winding and the third phase winding Astrocytic conditioned medium and with the axis of pedestal 1
It is arranged on the pedestal 1 for axial symmetry；
The pedestal 1 is cast iron base；
The head end U of first phase winding, second phase winding and the third phase winding1、V1、W1Respectively with three-phase
The output end L of power supply1、L2、L3Connection, the output electric current of the three phase mains are symmetrical three phase sine alternating current；
The pedestal 1 is in hollow structure, is equipped with split tunnel in enclosed space；
The input terminal of the split tunnel is connected to sampling injector 8 and infusion pump 7 respectively by triple valve 6.
The three phase mains obtains in the following manner:
Three-phase alternating voltage or single-phase AC voltage (frequency 50Hz) are become straight after the rectifier rectification of frequency converter 5
Galvanic electricity pressure becomes the three-phase alternating current with certain frequency and voltage using the inverter of frequency converter 5.
The three phase mains is input to the electric current of first phase winding, second phase winding and the third phase winding
Respectively iU、iV、iW, and iU、iV、iWMeet following formula:
According to each different instantaneous every phase winding electric currents and its direction come the case where analyzing 2 Distribution of Magnetic Field of three-phase windings.It is right
The waveform diagram of the three phase sine alternating current of title is as shown in Figure 2.Provide winding head end (U1、V1、W1) arrive end (U2、V2、W2)
Reference direction of the direction as electric current.In different time (angle) changes of magnetic field as caused by three-phase current:
As ω t=0 °, U phase current iU=0, W phase current iWFor positive value, i.e., from W1End flows into, in W2End outflow, V phase electricity
Flow iVFor negative value, i.e., from V2End flows into, in V1End outflow, according to the flow direction of electric current, using right-hand screw rule, by iVAnd iWIt generates
Resultant magnetic field such as Fig. 4 (a) shown in.
As ω t=60 °, shown in resultant magnetic field such as Fig. 4 (b) of current direction and three-phase current in three-phase windings 2.It closes
At magnetic field when the ω t=0 ° compared with rotated clockwise 60 °.As ω t=120 °, the resultant magnetic field of three-phase current such as Fig. 4
(c) shown in.Compared with resultant magnetic field is when ω t=60 °, and 60 ° are had rotated in the direction of the clock.Similarly, as ω t=180 °,
Resultant magnetic field when ω t=0 ° compared with have rotated 180 °.As ω t=360 °, resultant magnetic field is just improving one week.
The head end of first phase winding, second phase winding and the third phase winding is defeated with three phase mains respectively
When outlet is connected to, just there is symmetrical three phase sine alternating current i in three-phase windings 2U、iV、iWIt flows through, the synthesis that they are generated
Magnetic field is constantly rotating with the variation of electric current in winding space, forms rotating excitation field.
The split tunnel is microcapillary 3.
The length of the microcapillary 3 is meter level, internal diameter is micron order and in the shape of a spiral；
The inner wall of the pedestal 1 is equipped with plastic cylinder cylinder 4, and the inner wall of the plastic cylinder cylinder 4 is equipped with described for being embedded in
The helicla flute of microcapillary 3.
The output end of the split tunnel is connected to by ultraviolet-visible detector 9 with waste collection bottle 10.
Embodiment 2
A kind of magnetic particle field flow separator progress magnetic particles subfield according to described in embodiment 1 based on rotating excitation field
The method of flow separation has following steps:
S1, the three phase mains are distinguished defeated to first phase winding, second phase winding and the third phase winding
Enter electric current iU、iV、iW, rotating excitation field is formed in 1 enclosed space of pedestal, and the rotation is adjusted by the frequency converter 5
Voltage swing in the frequency and three-phase windings in magnetic field；
S2, in the case where the plastic cylinder barrel thickness is constant, pass through the inner diameter for changing the plastic cylinder cylinder
And outer diameter, the radial position of the microcapillary is adjusted, the induction level of the split tunnel position is changed；
S3, the magnetic particle of different magnetic susceptibility through the sampling injector 8 injection and the stream that is pumped into through the infusion pump 7
It is dynamic that the split tunnel is mutually entered from the input terminal of the split tunnel by the triple valve 6, carry out magnetic particle field flow point
From.
Magnetic particle identical for partial size adjusts the frequency and three-phase voltage size of rotating excitation field.When rotating excitation field
Magnetic particle is attracted to 3 upper tube wall of microcapillary when magnetic pole turns to the top of magnetic particle.The big magnetic particle of magnetic susceptibility leans on
3 upper tube wall of nearly microcapillary, but without reaching 3 upper tube wall of microcapillary, have a certain distance with 3 upper tube wall of microcapillary.Magnetic susceptibility
Small magnetic particle is farther from 3 upper tube wall of microcapillary, realizes the liquid stream layering of different magnetic susceptibility magnetic particles.Magnetic susceptibility is small
The big magnetic particle of magnetic particle relative magnetic susceptibility close to the center of liquid stream phase parabola flow pattern, migration velocity is big.Magnetization
The small magnetic particle of rate first flows out microcapillary 3, flows out followed by the big magnetic particle of magnetic susceptibility, realizes same particle size difference magnetic
The separation of rate magnetic particle.
Select acetonitrile as mobile phase, the rotation direction of rotating excitation field is identical as current-carrying direction, and liquid flowing speed is 0.4m L/
min.The frequency for adjusting frequency converter 5, keeps the speed of rotating excitation field smaller, is 2Hz.Saturation induction density is to measure magnetism
The physical quantity of particle magnetic susceptibility size.The big magnetic particle of magnetic susceptibility, saturation induction density are larger；The small magnetic particles of magnetic susceptibility
Son, saturation induction density are smaller.Saturation induction density is respectively the magnetic particle of 2.32emu/g and 3.50emu/g, particle
Diameter is 5.36 μm, and the sample volume of two components is 20 μ g, and the magnetic particle of both different magnetic responsivenesses can rotate
Good separation in magnetic field flow separator reaches separation analysis and requires.As shown in fig. 7, diameter is 5.36 μm, saturation induction
Intensity is respectively 2.32emu/g (peak a) and the 3.50emu/g (magnetic particle of peak b).
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (9)
1. a kind of magnetic particle field flow separator based on rotating excitation field, which is characterized in that including three-phase windings；
The three-phase windings include the first phase winding, the second phase winding and third phase winding；
First phase winding, second phase winding and the third phase winding Astrocytic conditioned medium and using the axis of pedestal as axis pair
Claim to be arranged on the pedestal；
The head end of first phase winding, second phase winding and the third phase winding respectively with the output end of three phase mains
Connection, the output electric current of the three phase mains are symmetrical three phase sine alternating current；
The pedestal is in hollow structure, is equipped with split tunnel in enclosed space；
The input terminal of the split tunnel is connected to sampling injector and infusion pump respectively by triple valve.
2. the magnetic particle field flow separator according to claim 1 based on rotating excitation field, it is characterised in that: described three
Phase power supply obtains in the following manner:
Three-phase alternating voltage or single-phase AC voltage are become into DC voltage after the rectifier rectification in frequency converter, using change
Inverter in frequency device becomes the three-phase alternating current with certain frequency and voltage.
3. the magnetic particle field flow separator according to claim 2 based on rotating excitation field, it is characterised in that: described three
The electric current of phase power input to first phase winding, second phase winding and the third phase winding is respectively iU、iV、iW,
And iU、iV、iWMeet following formula:
4. the magnetic particle field flow separator according to claim 3 based on rotating excitation field, it is characterised in that: described point
It is microcapillary or flat channel from channel.
5. the magnetic particle field flow separator according to claim 4 based on rotating excitation field, it is characterised in that: described micro-
The length of tubule is meter level, internal diameter is micron order and in the shape of a spiral；
The inner wall of the pedestal is equipped with plastic cylinder cylinder, and the inner wall of the plastic cylinder cylinder is equipped with for being embedded in the microcapillary
Helicla flute.
6. the magnetic particle field flow separator according to claim 1 based on rotating excitation field, it is characterised in that: described point
Output end from channel is connected to by ultraviolet-visible detector with waste collection bottle.
7. a kind of magnetic particle field flow separator according to claim 5 based on rotating excitation field carries out magnetic particles subfield
The method of flow separation, it is characterised in that there are following steps:
S1, the three phase mains input electricity to first phase winding, second phase winding and the third phase winding respectively
Flow iU、iV、iW, rotating excitation field is formed in the pedestal enclosed space, and the rotating excitation field is adjusted by the frequency converter
Voltage swing in frequency and three-phase windings；
S2, in the case where the plastic cylinder barrel thickness is constant, by changing the inner diameter of the plastic cylinder cylinder and outer
Wall diameter adjusts the radial position of the microcapillary, changes the induction level of the split tunnel position；
S3, the magnetic particle for the different magnetic susceptibility injected through the sampling injector and the flowing that is pumped into through the infusion pump communicate
It crosses the triple valve and enters the split tunnel from the input terminal of the split tunnel, carry out the separation of magnetic particle field flow.
8. according to the method described in claim 7, it is characterized by: the split tunnel is microcapillary or flat channel.
9. according to the method described in claim 8, it is characterized by: the length of the microcapillary is meter level, internal diameter is micron order
And in the shape of a spiral；
The inner wall of the pedestal is equipped with plastic cylinder cylinder, and the inner wall of the plastic cylinder cylinder is equipped with for being embedded in the microcapillary
Helicla flute.
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| CN201811327163.5A CN109365128B (en) | 2018-11-08 | 2018-11-08 | Magnetic particle field flow separation device and method based on rotating magnetic field |
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| CN201811327163.5A CN109365128B (en) | 2018-11-08 | 2018-11-08 | Magnetic particle field flow separation device and method based on rotating magnetic field |
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| CN109365128B CN109365128B (en) | 2021-03-02 |
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| CN114345545A (en) * | 2021-12-09 | 2022-04-15 | 大连交通大学 | Magnetic particle dynamic magnetophoresis separation device and method based on rotating magnetic field |
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| CN114345545B (en) * | 2021-12-09 | 2024-03-12 | 大连交通大学 | Magnetic particle dynamic magnetophoresis separation device and method based on rotating magnetic field |
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| CN109365128B (en) | 2021-03-02 |
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