CN109364154A - Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing - Google Patents
Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing Download PDFInfo
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- CN109364154A CN109364154A CN201811518114.XA CN201811518114A CN109364154A CN 109364154 A CN109364154 A CN 109364154A CN 201811518114 A CN201811518114 A CN 201811518114A CN 109364154 A CN109364154 A CN 109364154A
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- 239000002674 ointment Substances 0.000 title claims abstract description 85
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 85
- 239000008280 blood Substances 0.000 title claims abstract description 83
- 210000004369 blood Anatomy 0.000 title claims abstract description 83
- 230000005906 menstruation Effects 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 74
- 241000405911 Rehmannia glutinosa Species 0.000 claims abstract description 41
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000001035 drying Methods 0.000 claims abstract description 31
- 238000004821 distillation Methods 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 238000012545 processing Methods 0.000 claims abstract description 23
- 238000005303 weighing Methods 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 37
- 239000000706 filtrate Substances 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 12
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 9
- 239000005720 sucrose Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 8
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 6
- 229940069338 potassium sorbate Drugs 0.000 claims description 6
- 235000010241 potassium sorbate Nutrition 0.000 claims description 6
- 239000004302 potassium sorbate Substances 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000002791 soaking Methods 0.000 abstract description 23
- 239000003814 drug Substances 0.000 abstract description 6
- 238000000605 extraction Methods 0.000 abstract description 5
- 230000000052 comparative effect Effects 0.000 description 48
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 12
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 238000007654 immersion Methods 0.000 description 9
- 230000003020 moisturizing effect Effects 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 230000009977 dual effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000010025 steaming Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 2
- 241000405414 Rehmannia Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The Chinese medicinal ointment and preparation method thereof that the present invention relates to a kind of for menstruation regulating blood nourishing.This is used for the preparation method of the Chinese medicinal ointment of menstruation regulating blood nourishing the following steps are included: weighing raw material, Raw material processing, distillation, extraction, concentration and matching sugared step, obtains the Chinese medicinal ointment for menstruation regulating blood nourishing.Radix Angelicae Sinensis, Rehmannia glutinosa, Rhizoma Chuanxiong and the Radix Paeoniae Alba that the preparation method of Chinese medicinal ointment for menstruation regulating blood nourishing of the invention passes through selection special ratios, by Raw material processing, distillation, extraction, concentration, match each step of sugar, and accurately control Raw material processing step in each raw material drying temperature and the mild soaking time of soaking water in distilation steps, can effectively improve with the Radix Angelicae Sinensis menstruation regulating blood nourishing Chinese medicinal ointment Chinese medicine content rate of transform as main component.
Description
Technical field
The present invention relates to health care Chinese medicine field of pharmaceutical technology, more particularly to a kind of Chinese medicinal ointment for menstruation regulating blood nourishing and
Preparation method.
Background technique
Female pathology " being to use with blood based on blood ", therefore many pharmaceutical factories of traditional Chinese medicine have sale is various to be used for for women demand
The Chinese medicinal ointment of menstruation regulating blood nourishing.For in the Chinese medicinal ointment of menstruation regulating blood nourishing, mostly with Chinese medicines such as Radix Angelicae Sinensis, glutinous rehmannia, Rhizoma Chuanxiong and Radix Paeoniae Albas
The effect of material is primary raw material, reaches benefiting blood and regulating blood circulation, menstruction regulating and pain relieving.However such Chinese medicinal ointment is under traditional preparation method,
Often there is a problem of that the medicinal material content rate of transform is lower, causes Chinese medicinal ointment content's index that statutory standards are not achieved, drug effect is poor.
Summary of the invention
Based on this, it is necessary under traditional preparation method, with the Chinese medicinal ointment Chinese medicine content for menstruation regulating blood nourishing
The lower problem of the rate of transform provides a kind of preparation of Chinese medicinal ointment for menstruation regulating blood nourishing that can be improved the medicinal material content rate of transform
Method.
Specific technical solution is as follows:
A kind of preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing, comprising the following steps:
Weigh raw material: weighing Radix Angelicae Sinensis, Rehmannia glutinosa, Rhizoma Chuanxiong and Radix Paeoniae Alba, the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong with
And the mass ratio of the Radix Paeoniae Alba is 1~3:1~3:1~3:1~3；
Raw material processing: the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong and the Radix Paeoniae Alba are sliced, then distinguished
Dry, the drying temperature of the Radix Angelicae Sinensis is 45 DEG C~60 DEG C, and the drying temperature of the Rehmannia glutinosa is 60 DEG C~80 DEG C, the Rhizoma Chuanxiong
Drying temperature be 40 DEG C~60 DEG C, the drying temperature of the Radix Paeoniae Alba is 60 DEG C~80 DEG C；
Distillation: the Radix Angelicae Sinensis and the Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, and impregnating water temperature is 30 DEG C~40 DEG C,
Soaking time is 20min~40min, is then distilled, obtains distillation and distillate；
Extract: the distillation is mixed with the Rehmannia glutinosa and the Radix Paeoniae Alba, obtains mixture, to the mixture into
Row is decocted, is filtered, and obtains filtrate；
Concentration: the filtrate is concentrated, obtains clear cream；
With sugar: being dissolved by heating after adding water to mix with the clear cream sucrose, obtain thick paste；The steaming is added into the thick paste
Distillate is filtered after mixing evenly to get the Chinese medicinal ointment for menstruation regulating blood nourishing.
The Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong and the mass ratio of the Radix Paeoniae Alba are in one of the embodiments,
1:1:1:1.
In one of the embodiments, in the slicing treatment, the slice thickness of the Radix Angelicae Sinensis and the Radix Paeoniae Alba is
The slice thickness of 2mm~4mm, the Rehmannia glutinosa and the Rhizoma Chuanxiong is 5mm~10mm.
In one of the embodiments, in the distilation steps, the quality of the quality of the Radix Angelicae Sinensis and the Rhizoma Chuanxiong it
With with the mass ratio of water be 1:4~6.
The decoction processing includes the following steps: in one of the embodiments,
It decocts for the first time: adding water to be decocted to the mixture, the mass ratio of the mixture and water is 1:3~4, is obtained
First decocting liquid；
Second of decoction: water is added to be decocted to the mixture after decocting for the first time, after decocting for the first time
The mass ratio of the mixture and water is 1:3~4, obtains the second decocting liquid；
N-th decocts: adding water to be decocted to the mixture after the N-1 times decocts, after the N-1 times decocts
The mass ratio of the mixture and water is 1:3~4, obtains N decocting liquid；
First decocting liquid, second decocting liquid and the N decocting liquid are merged, is then filtered, obtains the filter
Liquid.
First time decocts in one of the embodiments, time, second of time decocted and described
The time that n-th decocts is 1h~1.5h.
It is described in sugared step in one of the embodiments, further include following operation: the thick paste is cooled to
The distillate is added after 50 DEG C~60 DEG C.
It is described in one of the embodiments, to match in sugared step, it further include following operation: described in being added into the thick paste
After distillate, then into the thick paste additive is added, stirs.
The additive is potassium sorbate in one of the embodiments,.
The present invention also provides a kind of Chinese medicinal ointments for menstruation regulating blood nourishing.
Specific technical solution is as follows:
A kind of Chinese medicinal ointment for menstruation regulating blood nourishing being prepared by above-mentioned preparation method.
Compared with prior art, the invention has the following advantages:
The preparation method of the above-mentioned Chinese medicinal ointment for menstruation regulating blood nourishing, by choose the Radix Angelicae Sinensis of special ratios, Rehmannia glutinosa,
Rhizoma Chuanxiong and Radix Paeoniae Alba by Raw material processing, distillation, extraction, concentration, match each step of sugar, and accurately control in Raw material processing step
Drying temperature and distilation steps in the mild soaking time of soaking water, the Chinese medicinal ointment for menstruation regulating blood nourishing is prepared.
Wherein, the accurate drying temperature of each raw material in control Raw material processing step, enable to the effective component of ingredients not because
Temperature is excessively high and is lost.The mild soaking time of soaking water in accurate control distilation steps, medicinal material extract when enabling to distill
Sufficiently, the medicinal material content rate of transform is improved.The above-mentioned Chinese medicinal ointment for menstruation regulating blood nourishing, the paeoniflorin content rate of transform are up to
70%, it is seen then that the preparation method of the above-mentioned Chinese medicinal ointment for menstruation regulating blood nourishing can be effectively improved using Radix Angelicae Sinensis as main component
The menstruation regulating blood nourishing Chinese medicinal ointment Chinese medicine content rate of transform.
Detailed description of the invention
Fig. 1 is the preparation method process flow chart described in one embodiment of the invention for the Chinese medicinal ointment of menstruation regulating blood nourishing.
Specific embodiment
It to facilitate the understanding of the present invention, below will be to invention is more fully described.But the present invention can be to be permitted
Mostly different form is realized, however it is not limited to embodiment described herein.On the contrary, purpose of providing these embodiments is makes
It is more thorough and comprehensive to the understanding of the disclosure.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
The present invention provides a kind of preparation methods of Chinese medicinal ointment for menstruation regulating blood nourishing comprising following steps:
Weigh raw material: weighing Radix Angelicae Sinensis, Rehmannia glutinosa, Rhizoma Chuanxiong and Radix Paeoniae Alba, the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong with
And the mass ratio of the Radix Paeoniae Alba is 1~3:1~3:1~3:1~3.
Raw material processing: the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong and the Radix Paeoniae Alba are sliced, then distinguished
Dry, the drying temperature of the Radix Angelicae Sinensis is 45 DEG C~60 DEG C, and the drying temperature of the Rehmannia glutinosa is 60 DEG C~80 DEG C, the Rhizoma Chuanxiong
Drying temperature be 40 DEG C~60 DEG C, the drying temperature of the Radix Paeoniae Alba is 60 DEG C~80 DEG C.In the slicing treatment, the Radix Angelicae Sinensis
And the slice thickness of the Radix Paeoniae Alba is 2mm~4mm, the slice thickness of the Rehmannia glutinosa and the Rhizoma Chuanxiong be 5mm~
10mm。
Distillation: the Radix Angelicae Sinensis and the Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, and impregnating water temperature is 30 DEG C~40 DEG C,
Soaking time is 20min~40min, is then distilled, obtains distillation and distillate.The quality of the Radix Angelicae Sinensis and the river
The quality sum of rhizome of chuanxiong and the volume ratio of the water are 1:4~6.
Extract: the distillation is mixed with the Rehmannia glutinosa and the Radix Paeoniae Alba, obtains mixture, to the mixture into
Row is decocted, is filtered, and obtains filtrate.
The decoction processing includes the following steps:
It decocts for the first time: adding water to be decocted to the mixture, the mass ratio of the mixture and water is 1:3~4, is obtained
First decocting liquid.
Second of decoction: water is added to be decocted to the mixture after decocting for the first time, after decocting for the first time
The mass ratio of the mixture and water is 1:3~4, obtains the second decocting liquid.
N-th decocts: adding water to be decocted to the mixture after the N-1 times decocts, after the N-1 times decocts
The mass ratio of the mixture and water is 1:3~4, obtains N decocting liquid.
First decocting liquid, second decocting liquid and the N decocting liquid are merged, is then filtered, obtains the filter
Liquid.
The time that time, second of the time decocted and the n-th that first time decocts decoct is
1h~1.5h.
Concentration: the filtrate is concentrated, obtains clear cream.
With sugar: being dissolved by heating after adding water to mix with the clear cream sucrose, obtain thick paste；The thick paste is carried out to be cooled to 50
DEG C~60 DEG C after the distillate is added, then additive is added into the thick paste, is filtered after mixing evenly to get for menstruation regulating
The Chinese medicinal ointment of blood-nourishing.The additive is potassium sorbate.
The present invention also provides a kind of use that the preparation method by the above-mentioned Chinese medicinal ointment for menstruation regulating blood nourishing is prepared
In the Chinese medicinal ointment of menstruation regulating blood nourishing.
Embodiment 1
A kind of Chinese medicinal ointment for menstruation regulating blood nourishing is present embodiments provided, preparation method includes the following steps (referring to
Fig. 1):
It weighs: weighing Radix Angelicae Sinensis 267.75kg, Rehmannia glutinosa 267.75kg, Rhizoma Chuanxiong 267.75kg and Radix Paeoniae Alba 267.75kg.
Raw material processing:
Radix Angelicae Sinensis: cleaning after taking Radix Angelicae Sinensis to remove impurity, be sliced after moisturizing, and slice thickness is 2mm~4mm, then dries, dry
Temperature is 50 DEG C.
Rehmannia glutinosa: taking Rehmannia glutinosa to be sliced, and slice thickness is 5mm~10mm, then dries, and drying temperature is 70 DEG C.
Wherein, Rehmannia glutinosa is steamed after moisturizing radix rehmanniae recen, and the black profit of radix rehmanniae recen epidermis is taken out, cooling, then is placed in gained in steaming liquid.
Rhizoma Chuanxiong: cleaning after taking Rhizoma Chuanxiong to remove impurity, be sliced after moisturizing, and slice thickness is 5mm~10mm, then dries, and does
Dry temperature is 50 DEG C.
Radix Paeoniae Alba: take Radix Paeoniae Alba to clean, moisturize after be sliced, slice thickness be 2mm~4mm, then dry, drying temperature 70
℃。
Distillation: Radix Angelicae Sinensis and Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, the quality of Radix Angelicae Sinensis and the quality sum of Rhizoma Chuanxiong
Mass ratio with water is 1:5, and impregnating water temperature is 35 DEG C, and then soaking time 30min is distilled, distillation time 2h is obtained
Distillation and distillate.
It extracts: distillation being mixed with Rehmannia glutinosa and Radix Paeoniae Alba, mixture is obtained, mixture is decocted, decoction processing
Include the following steps:
It decocting: being decocted to mixture plus water, decocting time 1h for the first time, the mass ratio of mixture and water is 1:3,
Obtain the first decocting liquid；
Second of decoction: water is added to be decocted to the mixture after decocting for the first time, decocting time 1.5h, through first
The mass ratio of mixture and water after secondary decoction is 1:3, obtains the second decocting liquid；
Third time decocts: adding water to be decocted to the mixture after decocting for the second time, decocting time 1.5h, through second
The mass ratio of mixture and water after secondary decoction is 1:3, obtains third decocting liquid；
First decocting liquid, the second decocting liquid and third decocting liquid are merged, is then filtered, obtains filtrate.
Concentration: carrying out reduced pressure filtrate using triple effect evaporator, obtains relative density and (surveys at 80 DEG C for 1.25~1.30
) clear cream.Wherein, the operating condition of triple effect evaporator are as follows: an effect vacuum degree: -0.02Mpa~-0.04Mpa, temperature: 70 DEG C
~85 DEG C；Two effect vacuum degrees: -0.04Mpa~-0.06Mpa, temperature: 60 DEG C~75 DEG C；Triple effect vacuum degree: -0.06Mpa~-
0.08Mpa, temperature: 50 DEG C~65 DEG C；Steam pressure: 0.05Mpa-0.09Mpa.
With sugar: adding water to mix with clear cream sucrose, be then heated to sucrose dissolution, obtaining relative density is 1.25~1.30
Thick paste；Thick paste is cooled down, distillate and potassium sorbate are added after being cooled to 60 DEG C, stir evenly refilter to get with
In the Chinese medicinal ointment of menstruation regulating blood nourishing.
Packing: the Chinese medicinal ointment to gained for menstruation regulating blood nourishing is dispensed according to 125g/ bottles, spiral cover, checks leakproofness.
Packaging: stamp is carried out to outer packing, is then packed according to 125g/ bottle/box × 80 boxes/case, obtains finished product, is stored in
Transfer storage facility.
Embodiment 2
A kind of Chinese medicinal ointment for menstruation regulating blood nourishing is present embodiments provided, preparation method includes the following steps (referring to
Fig. 1):
It weighs: weighing Radix Angelicae Sinensis 300kg, Rehmannia glutinosa 200kg, Rhizoma Chuanxiong 200kg and Radix Paeoniae Alba 100kg.
Raw material processing:
Radix Angelicae Sinensis: cleaning after taking Radix Angelicae Sinensis to remove impurity, be sliced after moisturizing, and slice thickness is 2mm~4mm, then dries, dry
Temperature is 40 DEG C.
Rehmannia glutinosa: taking Rehmannia glutinosa to be sliced, and slice thickness is 5mm~10mm, then dries, and drying temperature is 60 DEG C.
Wherein, Rehmannia glutinosa is steamed after moisturizing radix rehmanniae recen, and the black profit of radix rehmanniae recen epidermis is taken out, cooling, then is placed in gained in steaming liquid.
Rhizoma Chuanxiong: cleaning after taking Rhizoma Chuanxiong to remove impurity, be sliced after moisturizing, and slice thickness is 5mm~10mm, then dries, and does
Dry temperature is 40 DEG C.
Radix Paeoniae Alba: take Radix Paeoniae Alba to clean, moisturize after be sliced, slice thickness be 2mm~4mm, then dry, drying temperature 60
℃。
Distillation: Radix Angelicae Sinensis and Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, the quality of Radix Angelicae Sinensis and the quality sum of Rhizoma Chuanxiong
Mass ratio with water is 1:4, and impregnating water temperature is 30 DEG C, and then soaking time 40min is distilled, distillation time 2h is obtained
Distillation and distillate.
It extracts: distillation being mixed with Rehmannia glutinosa and Radix Paeoniae Alba, mixture is obtained, mixture is decocted, decocting time
It for 2.5h, then filters, obtains filtrate.
Concentration: being concentrated under reduced pressure filtrate with dual-effect concentrator, and obtaining relative density is the clear of 1.25~1.30 (measuring at 80 DEG C)
Cream；Wherein, the operating condition of dual-effect concentrator are as follows: an effect vacuum degree: -0.02Mpa~-0.04Mpa, temperature: 80 DEG C~90 DEG C；
Two effect vacuum degrees: -0.06Mpa~-0.08Mpa, temperature: 60 DEG C~70 DEG C.
With sugar: adding water to mix with clear cream sucrose, be then heated to sucrose dissolution, obtaining relative density is 1.25~1.30
Thick paste；Thick paste is carried out distillate and potassium sorbate are added after being cooled to 50 DEG C, stirs evenly and refilter to get for menstruation regulating
The Chinese medicinal ointment of blood-nourishing.
Packing: the Chinese medicinal ointment to gained for menstruation regulating blood nourishing is dispensed according to 125g/ bottles, spiral cover, checks leakproofness.
Packaging: stamp is carried out to outer packing, is then packed according to 125g/ bottle/box × 80 boxes/case, obtains finished product, is stored in
Transfer storage facility.
Embodiment 3
A kind of Chinese medicinal ointment for menstruation regulating blood nourishing is present embodiments provided, preparation method includes the following steps (referring to
Fig. 1):
It weighs: weighing Radix Angelicae Sinensis 200kg, Rehmannia glutinosa 100kg, Rhizoma Chuanxiong 200kg and Radix Paeoniae Alba 100kg.
Raw material processing: Radix Angelicae Sinensis: cleaning after taking Radix Angelicae Sinensis to remove impurity, be sliced after moisturizing, and slice thickness is 2mm~4mm, then
Dry, drying temperature is 60 DEG C.
Rehmannia glutinosa: taking Rehmannia glutinosa to be sliced, and slice thickness is 5mm~10mm, then dries, and drying temperature is 80 DEG C.
Wherein, Rehmannia glutinosa is steamed after moisturizing radix rehmanniae recen, and the black profit of radix rehmanniae recen epidermis is taken out, cooling, then is placed in gained in steaming liquid.
Rhizoma Chuanxiong: cleaning after taking Rhizoma Chuanxiong to remove impurity, be sliced after moisturizing, and slice thickness is 5mm~10mm, then dries, and does
Dry temperature is 60 DEG C.
Radix Paeoniae Alba: take Radix Paeoniae Alba to clean, moisturize after be sliced, slice thickness be 2mm~4mm, then dry, drying temperature 80
℃。
Distillation: Radix Angelicae Sinensis and Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, the quality of Radix Angelicae Sinensis and the quality sum of Rhizoma Chuanxiong
Mass ratio with water is 1:6, and impregnating water temperature is 40 DEG C, and then soaking time 20min is distilled, distillation time 2h is obtained
Distillation and distillate.
It extracts: distillation being mixed with Rehmannia glutinosa and Radix Paeoniae Alba, mixture is obtained, mixture is decocted, decoction processing
Include the following steps:
It decocting: being decocted to mixture plus water, decocting time 1h for the first time, the mass ratio of mixture and water is 1:5,
Obtain the first decocting liquid；
Second of decoction: water is added to be decocted to the mixture after decocting for the first time, decocting time 1.5h, through first
The mass ratio of mixture and water after secondary decoction is 1:4, obtains the second decocting liquid；
Third time decocts: adding water to be decocted to the mixture after decocting for the second time, decocting time 1.5h, through second
The mass ratio of mixture and water after secondary decoction is 1:4, obtains third decocting liquid；
First decocting liquid, the second decocting liquid and third decocting liquid are merged, is then filtered, obtains filtrate.
Concentration: being concentrated under reduced pressure filtrate with dual-effect concentrator, and obtaining relative density is the clear of 1.25~1.30 (measuring at 80 DEG C)
Cream；Wherein, the operating condition of dual-effect concentrator are as follows: an effect vacuum degree: -0.02Mpa~-0.04Mpa, temperature: 80 DEG C~90 DEG C；
Two effect vacuum degrees: -0.06Mpa~-0.08Mpa, temperature: 60 DEG C~70 DEG C.
With sugar: adding water to mix with clear cream sucrose, be then heated to sucrose dissolution, obtaining relative density is 1.25~1.30
Thick paste；Thick paste is carried out distillate and potassium sorbate are added after being cooled to 55 DEG C, stirs evenly and refilter to get for menstruation regulating
The Chinese medicinal ointment of blood-nourishing.
Packing: the Chinese medicinal ointment to gained for menstruation regulating blood nourishing is dispensed according to 125g/ bottles, spiral cover, checks leakproofness.
Packaging: stamp is carried out to outer packing, is then packed according to 125g/ bottle/box × 80 boxes/case, obtains finished product, is stored in
Transfer storage facility.
Comparative example 1
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 5 DEG C, then soaking time 30min is distilled.Other steps and embodiment 1
The Chinese medicinal ointment for menstruation regulating blood nourishing preparation method it is identical.
Comparative example 2
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 15 DEG C, then soaking time 30min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 3
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 25 DEG C, then soaking time 30min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 4
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 50 DEG C, then soaking time 30min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 5
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 60 DEG C, then soaking time 30min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 6
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 35 DEG C, then soaking time 10min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 7
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in distilation steps, by Radix Angelicae Sinensis and
Rhizoma Chuanxiong is added to the water immersion, and impregnating water temperature is 35 DEG C, then soaking time 50min is distilled.Other steps and embodiment
The preparation method of 1 Chinese medicinal ointment for menstruation regulating blood nourishing is identical.
Comparative example 8
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in Raw material processing step, Radix Angelicae Sinensis
Drying temperature is 70 DEG C, and the drying temperature of Rehmannia glutinosa is 90 DEG C, and the drying temperature of Rhizoma Chuanxiong is 70 DEG C, and the drying temperature of Radix Paeoniae Alba is 90
℃.Other steps are identical as the preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing of embodiment 1.
Comparative example 9
This comparative example provides a kind of Chinese medicinal ointment and preparation method thereof for menstruation regulating blood nourishing.
The preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing in this comparative example, in Raw material processing step, Radix Angelicae Sinensis
Drying temperature is 80 DEG C, and the drying temperature of Rehmannia glutinosa is 100 DEG C, and the drying temperature of Rhizoma Chuanxiong is 80 DEG C, and the drying temperature of Radix Paeoniae Alba is
100℃.Other steps are identical as the preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing of embodiment 1.
Experimental example 1
Turn for the content of Paeoniflorin in the Chinese medicinal ointment for menstruation regulating blood nourishing of Examples 1 to 3 and comparative example 1~9
Shifting rate is measured.
Experimental result is shown in the following table 1:
Table 1: the content of Paeoniflorin turns in the Chinese medicinal ointment for menstruation regulating blood nourishing of Examples 1 to 3 and comparative example 1~9
Shifting rate
| The content rate of transform of Paeoniflorin | |
| Embodiment 1 | 70.3% |
| Embodiment 2 | 65.8% |
| Embodiment 3 | 68.1% |
| Comparative example 1 | 30.4% |
| Comparative example 2 | 37.7% |
| Comparative example 3 | 45.8% |
| Comparative example 4 | 47.6% |
| Comparative example 5 | 42.6% |
| Comparative example 6 | 46.2% |
| Comparative example 7 | 50.1% |
| Comparative example 8 | 44.9% |
| Comparative example 9 | 37.3% |
Interpretation of result:
As shown in Table 1, in the Chinese medicinal ointment for menstruation regulating blood nourishing that Examples 1 to 3 is prepared, the content of Paeoniflorin turns
Shifting rate is higher, respectively 70.3%, 65.8% and 68.1%.
And in the Chinese medicinal ointment for menstruation regulating blood nourishing of comparative example 1~3, the content rate of transform of Paeoniflorin is respectively
30.4%, 37.7% and 45.8%.This is because before it is distilled, the immersion water temperature of Radix Angelicae Sinensis and Rhizoma Chuanxiong is too low, when distillation, works as
Return and Rhizoma Chuanxiong extraction is insufficient, has seriously affected the content rate of transform of Paeoniflorin.
In the Chinese medicinal ointment for menstruation regulating blood nourishing of comparative example 4 and comparative example 5, the content rate of transform of Paeoniflorin is respectively
47.6%, 42.6%.This is because before it is distilled, the immersion water temperature over-high of Radix Angelicae Sinensis and Rhizoma Chuanxiong, having in Radix Angelicae Sinensis and Rhizoma Chuanxiong
Ingredient part due to temperature is higher is imitated to be lost.
In the Chinese medicinal ointment for menstruation regulating blood nourishing of comparative example 6, the content rate of transform of Paeoniflorin is 46.2%.This is because
Before it is distilled, the soaking time of Radix Angelicae Sinensis and Rhizoma Chuanxiong is too short, and Radix Angelicae Sinensis and Rhizoma Chuanxiong extract insufficient when distillation.
In the Chinese medicinal ointment for menstruation regulating blood nourishing of comparative example 7, the content rate of transform of Paeoniflorin is 50.2%.Although being higher than
Comparative example 1~6, but still far below Examples 1 to 3.This is because before it is distilled, the long soaking time of Radix Angelicae Sinensis and Rhizoma Chuanxiong,
Effective component in Radix Angelicae Sinensis and Rhizoma Chuanxiong is lost in soaking process.
In the Chinese medicinal ointment for menstruation regulating blood nourishing of comparative example 8 and comparative example 9, the content rate of transform of Paeoniflorin is
44.9% and 37.3%.This is because in the preparation method of comparative example 8 and comparative example 9, for each original in Raw material processing step
The drying temperature of material is higher.The excessively high effective component that will lead in Radix Angelicae Sinensis, Rehmannia glutinosa, Rhizoma Chuanxiong and Radix Paeoniae Alba of temperature because temperature compared with
It is high and part is lost, affect the content rate of transform of Paeoniflorin.
The present invention for the Chinese medicinal ointment of menstruation regulating blood nourishing preparation method by choose the Radix Angelicae Sinensis of special ratios, Rehmannia glutinosa,
Rhizoma Chuanxiong and Radix Paeoniae Alba by Raw material processing, distillation, extraction, concentration, match each step of sugar, and accurately control in Raw material processing step
Each raw material drying temperature and the mild soaking time of soaking water in distilation steps, it is main for capable of effectively improving with Radix Angelicae Sinensis
The menstruation regulating blood nourishing Chinese medicinal ointment Chinese medicine content rate of transform of ingredient.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of preparation method of the Chinese medicinal ointment for menstruation regulating blood nourishing, which comprises the following steps:
It weighs raw material: weighing Radix Angelicae Sinensis, Rehmannia glutinosa, Rhizoma Chuanxiong and Radix Paeoniae Alba, the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong and institute
The mass ratio for stating Radix Paeoniae Alba is 1~3:1~3:1~3:1~3；
Raw material processing: being sliced the Radix Angelicae Sinensis, the Rehmannia glutinosa, the Rhizoma Chuanxiong and the Radix Paeoniae Alba, be then separately dried,
The drying temperature of the Radix Angelicae Sinensis is 45 DEG C~60 DEG C, and the drying temperature of the Rehmannia glutinosa is 60 DEG C~80 DEG C, and the Rhizoma Chuanxiong is done
Dry temperature is 40 DEG C~60 DEG C, and the drying temperature of the Radix Paeoniae Alba is 60 DEG C~80 DEG C；
Distillation: the Radix Angelicae Sinensis and the Rhizoma Chuanxiong being added to the water and impregnate to obtain soak, and impregnating water temperature is 30 DEG C~40 DEG C, impregnated
Time is 20min~40min, is then distilled, obtains distillation and distillate；
It extracts: the distillation being mixed with the Rehmannia glutinosa and the Radix Paeoniae Alba, obtains mixture, the mixture is carried out pan-fried
It boils, filter, obtain filtrate；
Concentration: the filtrate is concentrated, obtains clear cream；
With sugar: being dissolved by heating after adding water to mix with the clear cream sucrose, obtain thick paste；The distillation is added into the thick paste
Liquid is filtered after mixing evenly to get the Chinese medicinal ointment for menstruation regulating blood nourishing.
2. the preparation method of the Chinese medicinal ointment according to claim 1 for menstruation regulating blood nourishing, which is characterized in that described to work as
Return, the mass ratio of the Rehmannia glutinosa, the Rhizoma Chuanxiong and the Radix Paeoniae Alba is 1:1:1:1.
3. the preparation method of the Chinese medicinal ointment according to claim 1 for menstruation regulating blood nourishing, which is characterized in that the slice
In processing, the slice thickness of the Radix Angelicae Sinensis and the Radix Paeoniae Alba is 2mm~4mm, and the Rehmannia glutinosa and the Rhizoma Chuanxiong are cut
Piece thickness is 5mm~10mm.
4. the preparation method of the Chinese medicinal ointment according to claim 1 for menstruation regulating blood nourishing, which is characterized in that the distillation
In step, the mass ratio of the quality sum and water of the quality of the Radix Angelicae Sinensis and the Rhizoma Chuanxiong is 1:4~6.
5. the preparation method described in any one for the Chinese medicinal ointment of menstruation regulating blood nourishing, feature exist according to claim 1~4
In the decoction processing includes the following steps:
It decocts for the first time: adding water to be decocted to the mixture, the mass ratio of the mixture and water is 1:3~4, obtains first
Decocting liquid；
Second decocts: add water to be decocted to the mixture after decocting for the first time, after decocting for the first time described in
The mass ratio of mixture and water is 1:3~4, obtains the second decocting liquid；
N-th decoct: to through the N-1 time decoct after the mixture add water to be decocted, through the N-1 times decoction after described in
The mass ratio of mixture and water is 1:3~4, obtains N decocting liquid；
First decocting liquid, second decocting liquid and the N decocting liquid are merged, is then filtered, obtains the filtrate.
6. the preparation method of the Chinese medicinal ointment according to claim 5 for menstruation regulating blood nourishing, which is characterized in that described first
The time that the time of secondary decoction, second of the time decocted and the n-th decoct is 1h~1.5h.
7. the preparation method described in any one for the Chinese medicinal ointment of menstruation regulating blood nourishing, feature exist according to claim 1~4
In, it is described in sugared step, further include following operation: the thick paste being carried out the distillation is added after being cooled to 50 DEG C~60 DEG C
Liquid.
8. the preparation method of the Chinese medicinal ointment according to claim 7 for menstruation regulating blood nourishing, which is characterized in that described with sugar
Further include following operation in step: after the distillate is added into the thick paste, then into the thick paste additive be added,
Stirring.
9. the preparation method of the Chinese medicinal ointment according to claim 8 for menstruation regulating blood nourishing, which is characterized in that the addition
Agent is potassium sorbate.
10. a kind of traditional Chinese medicinal ointment for menstruation regulating blood nourishing being prepared by preparation method described in any one of claim 1 to 9
Agent.
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Application publication date: 20190222 |