CN109363725B

CN109363725B - Negative pressure type liquid specimen collecting device

Info

Publication number: CN109363725B
Application number: CN201811262140.0A
Authority: CN
Inventors: 罗燕; 刘奕志; 林晓峰; 吕林
Original assignee: Zhongshan Ophthalmic Center
Current assignee: Zhongshan Ophthalmic Center
Priority date: 2018-04-11
Filing date: 2018-10-27
Publication date: 2021-09-28
Anticipated expiration: 2038-10-27
Also published as: CN113693639A; CN113693639B; CN108433747A; CN113951936B; CN109363725A; CN113951936A

Abstract

The invention provides a negative pressure type liquid specimen collecting device, which comprises: the liquid storage pipe is provided with a sealed cavity, and the air pressure of the sealed cavity is negative pressure; the flow guide pipe body is communicated with the sealed cavity of the liquid storage pipe and is provided with a flow guide inlet, a flow guide outlet and a valve arranged between the flow guide inlet and the flow guide outlet, and the valve controls the communication and the closing of the flow guide inlet and the flow guide outlet; and a piercing member for piercing the tissue body and communicating with the fluid outlet of the fluid guide tube body. In the invention, a doctor and the like can conveniently and safely automatically collect the liquid specimen for a tissue body (such as the vitreous body of an eye) through the puncturing part, and can conveniently and directly carry out subsequent detection on the liquid specimen stored in the liquid storage tube.

Description

Negative pressure type liquid specimen collecting device

Technical Field

The invention relates to the field of medical instruments, in particular to a negative pressure type liquid specimen collecting device.

Background

In medical research, liquid specimens in tissues have important clinical and scientific research values. For example, in common clinical specimens for ophthalmology, liquid specimens such as vitreous humor and aqueous humor have extremely important clinical and scientific research values for diagnosis and treatment of etiology of vitreoretinal disease and uveitis, glaucoma ocular hypotension and the like. Therefore, the effective collection and preservation of liquid specimens are also important links in the treatment process of clinical operation and the like.

For liquid specimens in ophthalmology, for example, aspiration by puncturing has once become the main method for obtaining liquid specimens, but because this method has high requirements for the surgeon's operation skill and collection site, and the operation process of aspiration by puncturing is poorly controllable, the surgeon needs to manually extract the liquid specimen from the tissue body. At present, the common ophthalmological liquid specimen collecting method has the following problems: (1) the amount of the liquid specimen in the eye which can be collected is small, for example, when the aqueous humor is collected by anterior chamber puncture, the eyeball must be pressed for many times in order to obtain enough amount of specimen, and complications are easy to cause; (2) the syringe is used as a collecting device of the liquid specimen, but the method needs the doctor to operate by both hands simultaneously, has poor controllability and is easy to cause operation complications due to over-violent suction; (3) the sample is stored at the needle head part, so that the sample which is difficult to take is not lost much; (4) the process of transferring and storing the samples collected on the operating table into the liquid storage pipe is various, and the workload of a specimen taking doctor is increased; (5) in addition to the fact that a vitreous cutting operation can obtain more vitreous humor, no good minimally invasive method for collecting the vitreous humor is available.

Disclosure of Invention

The present invention has been made in view of the above-described conventional circumstances, and an object thereof is to provide a negative pressure type liquid specimen collecting device which is easy and safe to handle.

Therefore, the invention provides a negative pressure type liquid specimen collecting device, which comprises: the liquid storage pipe is provided with a sealed cavity, and the air pressure of the sealed cavity is negative pressure; the flow guide pipe body is communicated with the sealed cavity of the liquid storage pipe and is provided with a flow guide inlet, a flow guide outlet and a valve arranged between the flow guide inlet and the flow guide outlet, and the valve controls the communication and the closing of the flow guide inlet and the flow guide outlet; and a piercing member for piercing a tissue body and communicating with the flow guide inlet of the flow guide tube body.

In the invention, an operator such as a doctor, a nurse or other professionals can conveniently and automatically collect the liquid specimen through the puncturing part to the tissue body (such as the anterior chamber of the eye or the vitreous body) through negative pressure, and can conveniently and directly carry out subsequent detection on the collected liquid specimen stored in the liquid storage tube, thereby being particularly suitable for collecting aqueous humor and vitreous humor in ophthalmology.

In the collecting device according to the present invention, the liquid storage tube is detachably connected to the flow guide tube body. Therefore, after the liquid specimen of the liquid storage tube is collected, the liquid storage tube can be conveniently separated independently, and subsequent detection steps can be directly carried out.

In addition, in the collecting device according to the present invention, the valve may be a push type mechanical valve. From this, can make things convenient for operating personnel such as doctor to operate the valve of water conservancy diversion body to conveniently control the collection of liquid sample.

In the collecting device according to the present invention, the liquid specimen may be vitreous humor in an eye. In this case, the vitreous humor in the eye can be conveniently and automatically collected by the negative pressure (lower than the intraocular pressure) characteristic in the liquid storage tube.

In the collecting device according to the present invention, the piercing member may be provided with a stopper mechanism for limiting the piercing depth. Therefore, the puncturing position of the puncturing component can be controlled more accurately, and the reliability of the operation is improved.

In addition, in the collecting device according to the present invention, the outer surface of the liquid storage tube may be provided with anti-slip stripes. Therefore, the liquid storage pipe can be conveniently taken down by an operator such as a doctor.

In the collecting device according to the present invention, the liquid storage tube may be a transparent tube. Therefore, operators such as doctors and the like can conveniently observe the collection condition of the liquid specimen of the liquid storage tube in real time.

In the collecting device according to the present invention, the liquid storage tube may be provided with a scale. Thus, an operator such as a doctor can know the amount of the liquid specimen collected in real time.

In addition, the collecting device according to the present invention further includes a cap detachably covering the piercing member. Therefore, the collecting device can be ensured to be in a sealing state, and the puncturing part is prevented from accidentally injuring an operator.

In the collecting device according to the present invention, the piercing member may be a needle tube. Therefore, operators such as doctors can conveniently puncture the tissue body to collect the liquid specimen.

According to the present invention, it is possible to provide a negative pressure type liquid specimen collecting device which is easy and safe to handle.

Drawings

Fig. 1 is a schematic diagram showing a negative pressure type liquid specimen collecting device according to an embodiment of the present invention.

Fig. 2 is a perspective view showing a negative pressure type liquid specimen collecting apparatus according to an embodiment of the present invention.

Fig. 3 is an exploded schematic view illustrating the collecting apparatus shown in fig. 2.

Fig. 4 is a schematic view showing a fluid guide tube body of the collecting device shown in fig. 2.

Fig. 5 is a perspective view showing a guide tube body of the collecting device shown in fig. 2.

Fig. 6 is a sectional view showing the guide pipe body along the sectional line a-a' of fig. 5.

Fig. 7 is a perspective view showing a piercing member of the collecting apparatus according to the embodiment of the present invention.

Fig. 8 is a schematic diagram showing a path of the collecting apparatus according to the embodiment of the present invention.

Fig. 9 is a diagram showing a state of use of the piercing member of the collecting apparatus according to the embodiment of the present invention.

Fig. 10 is a perspective view showing a cap of the collecting apparatus according to the embodiment of the present invention.

Detailed Description

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, the same components are denoted by the same reference numerals, and redundant description thereof is omitted. The drawings are schematic and the ratio of the dimensions of the components and the shapes of the components may be different from the actual ones.

It is noted that, as used herein, the terms "comprises," "comprising," or any other variation thereof, such that a process, method, system, article, or apparatus that comprises or has a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include or have other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Fig. 1 is a schematic diagram showing a negative pressure type liquid specimen collecting device according to an embodiment of the present invention. Fig. 2 is a perspective view showing a liquid specimen collecting apparatus according to an embodiment of the present invention. Fig. 3 is an exploded schematic view illustrating the collecting apparatus shown in fig. 2.

As shown in fig. 1, a liquid specimen collecting device (hereinafter, sometimes referred to as "collecting device") 1 according to the present embodiment includes a liquid storage tube 10, a catheter body 20, and a piercing member 30. The catheter body 20 has a valve 23 (described later) for controlling the communication between the liquid storage tube 10 and the piercing member 30, so that an operator such as a doctor, a nurse or other professionals can conveniently and automatically collect the liquid specimen in the tissue (e.g. vitreous body of eye) through the piercing member 30 by negative pressure, and can conveniently and directly perform subsequent detection on the collected liquid specimen stored in the liquid storage tube.

In this embodiment, the reservoir tube 10 may have a sealed chamber 11, and the pressure of the sealed chamber 11 may be negative. Here, the negative pressure is set according to different usage purposes, that is, the sealed cavity 11 of the liquid storage tube 10 can be made to have different negative pressures according to the liquid specimens in different tissues to be collected, and the negative pressure is defined as the air pressure in the sealed cavity 11 is smaller than the air pressure in the tissues. For example, for a liquid specimen in the eye, such as vitreous humor, the corresponding negative pressure is a pressure less than the intraocular pressure.

In some examples, the sealed cavity 11 may be formed as a negative pressure environment having an air pressure less than a prescribed air pressure, thereby enabling automatic collection of a liquid specimen. In addition, to better utilize negative pressure for automatic collection, the sealed chamber 11 is typically sealed relative to the pressure within the tissue body. In some examples, the air pressure of the sealed chamber 11 may be set to 5000Pa, 1000Pa, 500Pa, 100Pa, etc., for example, according to different usage purposes.

The volume of the sealed chamber 11 of the reservoir tube 10 is not particularly limited, and may be 1mL to 20mL, 20mL to 50mL, or 1mL to 100 mL. For example, for an ophthalmic liquid specimen, the volume (volume) of the sealed cavity 11 may be 0.05mL to 0.1mL, 0.1mL to 0.20mL, or 0.20mL to 0.50 mL.

In some examples, the collecting device 1 according to the present embodiment may be provided in different models, and accordingly, the volume and the magnitude of the negative pressure in the liquid storage tube 10 may be different. This can improve the applicability of the collecting apparatus 1.

In some examples, the reservoir tube 10 may be a hollow cylinder. In addition, in other examples, the reservoir tube 10 may have a hollow rectangular parallelepiped, a hollow polygonal prism, or the like. Therefore, the liquid specimen collecting device can be suitable for collecting liquid specimens with different purposes.

In some examples, the bottom of the reservoir tube 10 may be flat, thereby enabling facilitated placement of the reservoir tube 10. In addition, in some examples, the bottom of the reservoir tube 10 may also be concave, in which case placement of the reservoir tube 10 may also be facilitated.

In some examples, the reservoir tube 10 may be made of plastic, glass, or metal, among other materials. In this way, in actual clinical applications, an operator such as a doctor can select the liquid storage tube 10 of different materials for different liquid samples.

In some examples, the reservoir tube 10 may be a transparent tube. Therefore, operators such as doctors and the like can conveniently observe the collection condition of the liquid specimen of the liquid storage tube in real time. In some examples, the reservoir tube 10 may be a transparent glass or plastic tube. Further, in some examples, a scale may be provided on the reservoir tube 10. For example, a scale for indicating the volume of the reservoir is provided on the outer surface of the reservoir 10. In this case, the operator such as a doctor can know the amount of the liquid specimen collected in real time.

In some examples, the liquid sample collected by the collection device 1 may be vitreous humor in the eye. In this case, the vitreous humor in the eye can be automatically collected conveniently by the negative pressure (lower than the intraocular pressure) characteristic in the reservoir tube 10.

In some examples, an anti-slip mechanism may be provided on the outer surface of the reservoir tube 10. Therefore, the liquid storage tube 10 can be conveniently taken down by an operator such as a doctor. In other examples, the outer surface of the liquid storage tube 10 may be provided with a plurality of protrusions (not shown), which may facilitate the operator such as a doctor to remove the liquid storage tube 10, and prevent the liquid storage tube 10 from slipping off the hand of the operator.

In some examples, the reservoir tube 10 may be additionally provided with a sealing cap (not shown). For example, after the liquid storage tube 10 collects the liquid specimen, the liquid specimen can be detached from the catheter body 20, and the sealing cover is used to cover the liquid storage tube 10, so that the liquid specimen of the subsequent liquid storage tube 10 is prevented from being polluted by the outside, and the subsequent liquid specimen of the liquid storage tube 10 can be conveniently stored or checked.

Fig. 4 is a schematic view showing a fluid guide tube body of the collecting device shown in fig. 2. Fig. 5 is a perspective view showing a guide tube body of the collecting device shown in fig. 2. Fig. 6 is a schematic sectional view showing the guide pipe body along the line a-a' of fig. 5.

In the collecting device 1 according to the present embodiment, the guide tube body 20 is connected to and communicates with the reservoir tube 10, that is, a passage is formed between the guide tube body 20 and the reservoir tube 10. Specifically, the guide tube 20 may communicate with the sealed cavity 11 of the reservoir 10, and the sealed cavity 11 is in a negative pressure state, so that the liquid specimen may flow into the sealed cavity 11 of the reservoir 10 through the guide tube 20.

In some examples, the catheter body 20 may form a luer connection with the reservoir 10. For example, one end of the catheter body 20 is a luer connector to form a luer connection with the reservoir 10. In this case, the guide duct body 20 can be detachably mounted to the reservoir pipe 10.

In addition, the guide pipe body 20 has a guide inlet 21, a guide outlet 22, and a valve 23 disposed between the guide inlet 21 and the guide outlet 22.

In the present embodiment, the diversion inlet 21 may be connected to a piercing member 30 (described later), the diversion outlet 22 may communicate with the reservoir 10, and the opening and closing between the diversion inlet 21 and the diversion outlet 22 is controlled by a valve 23. In this case, the valve 23 can be controlled to control the communication and closing of the liquid storage tube 10 and the piercing member 30 (especially, the liquid specimen in the tissue body pierced by the piercing member 30).

In some examples, the reservoir 10 is removably coupled to the catheter body 20. Therefore, after the liquid specimen of the liquid storage tube 10 is collected, the liquid storage tube 10 can be conveniently separated independently, and the subsequent detection steps are directly carried out. For example, the liquid storage tube 10 can be detached from the catheter body 20, and the liquid storage tube 10 with the liquid specimen is directly subjected to subsequent medical detection, so that the detection time can be saved, and the efficiency of clinical medical treatment can be improved. In some examples, the valve 23 may be a push-type mechanical valve. Under this condition, can make things convenient for operating personnel such as doctor to operate the valve 23 of water conservancy diversion body to conveniently control the collection of liquid sample. Specifically, the operator such as a doctor can control the automatic collection of the liquid specimen by easily pressing the valve 23, thereby improving the efficiency of the clinical operation by the doctor or the like.

As shown in fig. 5 and 6, in the present embodiment, the valve 23 may generally include a pressing head 231, a rod 232 connected to the pressing head 231, an inner cavity engaged with the rod 232, a sealing ring 233 and a sealing ring 234 respectively disposed at different positions of the rod 232, and an elastic member 235 disposed in the inner cavity 236.

In some examples, the pressing head 231 may have a pie shape, thereby facilitating access for a doctor or other operator to perform pressing or other operations. In addition, as shown in fig. 2, a case where the pressing head 231 is at one side of the valve 23 is illustrated, but the present disclosure is not limited thereto, and in some examples, the pressing head 231 may also be provided at the other side of the valve 23.

In the valve 23, the elastic member 235 is changed by pressing the pressing head 231, so that at least a first position and a second position of the rod body 232 in the inner cavity 236 are set. For example, when the rod 232 presses the spring 235 to be in the first position, the end 21a of the fluid inlet 21 and the end 22a of the fluid outlet 22 are located between the sealing ring 233 and the sealing ring 234, in this case, the fluid inlet 21 and the fluid outlet 22 are communicated via the space 236, and the reservoir 10 is communicated with the outside (tissue) via the fluid inlet 21, the fluid outlet 22 and the piercing member 30; for example, when the rod 232 presses the spring 235 to be in the second position, for example, one end 21a of the fluid inlet 21 is located between the sealing ring 233 and the sealing ring 234, in this case, the fluid inlet 21 is not communicated with the fluid outlet 22, and the fluid storage tube 10 is isolated from the outside. In this way, the opening and closing of the valve 23 can be controlled by the pressing head 231, thereby conveniently controlling the communication and isolation of the liquid storage tube 10 having a negative pressure environment with the outside.

In the present embodiment, the material of the valve 23 is not particularly limited, and in some examples, the valve 23 may be made of plastic, glass, or metal. The valve 23 is preferably made of a metal material from the viewpoint of durability.

In addition, an airtight plug 24 for implementing the reservoir pipe 10 as a negative pressure may be further provided in the guide pipe body 20. Specifically, when the guide tube body 20 (specifically, the guide outlet 22 of the guide tube body 20) is in communication with the reservoir tube 10, for example, a needle is inserted into a passage from the air-tight plug 24 to the guide outlet 22, and the valve 23 is kept in a closed state (at this time, the guide inlet 21 is not in communication with the guide outlet 22), and therefore, the sealed cavity 11 of the reservoir tube 10 can be conveniently brought into a predetermined negative pressure environment, for example, an environment lower than the intraocular pressure.

In addition, the airtight plug 24 can maintain the negative pressure of the reservoir pipe 10. Specifically, after the vacuum is drawn through the airtight plug 24, the airtight plug 24 can return to its original state to block the passage, and therefore the airtight plug 24 can maintain the negative pressure environment of the liquid storage tube 10. In some examples, the airtight plug 24 may be a rubber plug.

Further, as described above, the liquid storage tube 10 is connected to the guide tube body 20, and the airtight plug 24 is formed at one end of the guide outlet 22 of the guide tube body 20, in order to ensure that the airtight plug 24 can be used to realize the negative pressure treatment inlet of the liquid storage tube 10, at least a portion of the airtight plug 24 (see fig. 8) needs to be exposed when the liquid storage tube 10 is connected to the guide tube body 20, so that, for example, a needle for vacuum extraction can be inserted into the airtight plug 24.

In some examples, the seal rings 233 and 234 may be composed of a medical grade rubber, such as silicone rubber. In other examples, the sealing rings 233 and 234 may be made of other medical materials such as plastic, glass resin, synthetic compound, etc. Thereby, the airtightness of the valve 23 can be ensured while ensuring that the requirements of the medical instrument for the material are satisfied.

Additionally, in some examples, the valve 23 may also be an electrically actuated valve. For example, the valve may detect a change in air pressure or hydraulic pressure at the same time, and when the electric valve detects that the air pressure or hydraulic pressure is lower than a certain value after opening, the electric valve automatically closes to disconnect the pilot inlet 21 from the pilot outlet 22. In this case, it is possible to more conveniently operate the valve 23 by an operator.

Fig. 7 is a perspective view showing a piercing member of the collecting apparatus according to the embodiment of the present invention. Fig. 8 is a schematic diagram showing a path of the collecting apparatus according to the embodiment of the present invention. Fig. 9 is a diagram showing a state of use of the piercing member of the collecting apparatus according to the embodiment of the present invention. Fig. 10 is a perspective view showing a cap of the collecting apparatus according to the embodiment of the present invention. In fig. 7, an example in which the collection device 1 is used to collect the vitreous humor in the eyeball 2 is shown for convenience of application example, but the present invention is not limited thereto.

As shown in fig. 7, the piercing member 30 may include a main body 31 and a piercing part 32 connected to the main body 31. In addition, the body 31 may be in communication with the piercing portion 32, whereby the liquid specimen can flow through the piercing member 30 to the catheter body 20.

In some examples, a narrow passageway is formed in the piercing member 30 between the body 31 and the piercing portion 32 (see fig. 8), thereby ensuring that the liquid specimen does not become depleted from residing within the body 31 or the piercing portion 32 as it flows through the piercing member 30. This configuration is particularly useful in the case of extraction of low-dose liquid specimens, such as aqueous humor.

In some examples, the piercing member 30 may form a luer connection with the catheter body 20. For example, the end of the catheter body 20 near the catheter inlet 21 forms a luer connection with the piercing member 30.

Additionally, in some examples, the piercing member 30 may be formed as an integral part of the catheter body 20. In this case, the piercing member 30 may be a portion that is drawn out of the catheter body 20.

In some examples, a stop mechanism 33 may be provided at the piercing member 30 to limit the piercing location. Specifically, a stopper mechanism 33 for restricting a piercing portion is provided between the main body 31 and the piercing portion 32 of the piercing member 30. Under the condition, when a doctor and the like penetrate the penetrating component 30 into a tissue body, the penetrating (penetrating) part of the penetrating component 30 is limited, so that the doctor and the like can conveniently control the penetration depth of the penetrating component 30 when collecting aqueous humor, the penetrating part of the penetrating component 30 can be more accurately controlled, the situation that the patient receives secondary injury due to too deep penetration is effectively avoided, and the reliability of the operation is improved.

Here, the piercing portion is a portion where the piercing member 30 pierces a tissue, specifically, a tissue containing a liquid specimen is pierced to communicate the liquid specimen in the tissue with the sealed cavity 11 of the reservoir tube 10, and then the liquid specimen in the tissue is automatically collected by the negative pressure of the reservoir tube 10.

In the case of the example of fig. 9 where the puncturing member 30 is inserted into the eyeball 2 to obtain the vitreous humor sample, the puncturing site should be kept away from the iris or the like to avoid damage to the tissue. In addition, the operation direction of the piercing member 30 and the depth of the piercing portion 31 of the piercing member 30 penetrating into the eyeball shown in fig. 9 are only exemplary functions.

In some examples, the stop mechanism 33 may be designed to conform to the surface of the tissue body, thereby enabling automatic alignment of the piercing portion 32 of the piercing member 30 to the piercing site. Therefore, the puncture operation can be conveniently carried out by operators such as doctors.

In some examples, the piercing member 30 may have a protrusion 34. The protrusion 34 facilitates removal of the piercing member 30 from the catheter body 20 or attachment of the piercing member 30 to the catheter body 20. The protrusion 34 may be provided in two opposing positions to facilitate removal of the piercing member 30 from the catheter body 20 or attachment of the piercing member 30 to the catheter body 20.

In some examples, the piercing member 30 may also be tapered along the length. Therefore, operators such as doctors can conveniently puncture the tissue, and the reliability and the stability are improved.

Additionally, in some examples, the piercing member 30 may be a needle cannula. In this case, since the tip of the needle tube is pointed, it is possible to easily pierce a tissue such as an eyeball. Therefore, operators such as doctors can conveniently puncture the tissue body to collect the liquid specimen.

In some examples, the needle outer diameter of the needle tube as the piercing member 30 may be 0.31 to 4.57mm, and the needle inner diameter may be 0.15 to 3.81 mm. For collecting liquid samples of ophthalmology and the like, the outer diameter of the needle head of the needle tube is preferably 0.31mm to 0.64mm, and the inner diameter of the needle tube is preferably 0.15mm to 0.33mm, so that the liquid samples can be effectively collected, the wound can be minimized, and the samples can be safely and minimally collected.

As described above, the reservoir 1, the guide tube body 2, and the piercing member 3 are connected to each other to form a narrow passage (as shown in fig. 8), so that the liquid specimen can be automatically collected into the reservoir 1 through the piercing member 3 and the guide tube body 2. Under the condition, the liquid specimen can be effectively collected as much as possible, the trauma can be minimized, and the specimen can be safely and minimally invasively collected.

In the present embodiment, the length of the piercing portion 32 of the piercing member 30 is not particularly limited, and for example, in the case of an ophthalmic liquid specimen such as a vitreous humor, it is sufficient that the liquid specimen can penetrate into the vitreous humor of the eye.

In the present embodiment, the collecting device 1 may further have a cover 40 (see fig. 3). In some examples, the cap 40 is removably mounted to the piercing member 30. As shown in fig. 3, the liquid storage tube 10, the catheter body 20, the puncturing member 30, and the cap 40 are assembled together, so that the collecting apparatus 1 can be protected, and the puncturing member 40 can be prevented from accidentally injuring an operator such as a doctor. In addition, the cap 40 can block dust and prevent the piercing member 30 from being contaminated by dust and the like.

In some examples, the cap 40 may be an airtight cap that covers the piercing member 30. This can further ensure the negative pressure state of the reservoir pipe 10.

Additionally, in some examples, the cap 40 may also cover both the piercing member 30 and the valve 23. In this case, the valve 23 can be protected by the cap 40 to prevent the valve 23 from being operated by mistake. Here, the rear end of the cap 40 may be adaptively adjusted according to the structure of the valve 23 so as to be able to fittingly cover the valve 23.

In some examples, the cap 40 may be made of plastic, glass, metal, etc. In some examples, the cap 40 may have various shapes such as a cylinder, a rectangular parallelepiped, a polygonal prism, or an irregular shape.

In some examples, the outer wall of the cap 40 may be further provided with an anti-slip stripe (see fig. 10). In some examples, the anti-slip stripe 41 may be provided with a plurality of stripes, for example, four, eight, or twelve stripes along the outer circumferential direction of the cover 40. In some examples, the anti-slip stripe 41 may be formed in an elongated shape along the length direction of the cap 40.

In addition, in other examples, a protrusion may be provided on the outer wall of the cap 40. In other examples, the outer wall of the cover 40 may also be provided with an anti-slip cover. This prevents slippage during use.

While the invention has been specifically described above in connection with the drawings and examples, it will be understood that the above description is not intended to limit the invention in any way. Those skilled in the art can make modifications and variations to the present invention as needed without departing from the true spirit and scope of the invention, and such modifications and variations are within the scope of the invention.

Claims

1. A negative pressure type liquid specimen collecting device, which is characterized in that,

the method comprises the following steps:

the liquid storage pipe is provided with a sealed cavity, and the air pressure of the sealed cavity is negative pressure;

the flow guide pipe body is communicated with the sealed cavity of the liquid storage pipe and is provided with a flow guide inlet, a flow guide outlet and a valve arranged between the flow guide inlet and the flow guide outlet, and the valve controls the communication and the closing of the flow guide inlet and the flow guide outlet; and

a piercing member for piercing a tissue body and communicating with the flow guide inlet of the flow guide tube body,

wherein, the valve comprises a pressing head, a rod body connected with the pressing head, an inner cavity matched with the rod body, a first sealing ring and a second sealing ring which are respectively arranged at different positions of the rod body, and an elastic component arranged in the inner cavity, when the rod body is positioned at the first position of the inner cavity, one end of the flow guide inlet and one end of the flow guide outlet are positioned between the first sealing ring and the second sealing ring, the flow guide inlet is communicated with the flow guide outlet through the inner cavity, the flow guide inlet, the flow guide outlet are communicated with the piercing component, when the rod body is positioned at the second position of the inner cavity, one end of the flow guide inlet is positioned between the first sealing ring and the second sealing ring, and the flow guide inlet is not communicated with the flow guide outlet,

an airtight plug for forming the liquid storage tube into negative pressure is provided in the guide tube body near the guide outlet, at least a part of the airtight plug is exposed when the liquid storage tube is connected to the guide tube body, and the liquid storage tube is formed into negative pressure by inserting a needle tube into a passage formed by the airtight plug and the guide outlet and performing a vacuum process while keeping the valve closed.

2. The acquisition device as set forth in claim 1,

the liquid storage pipe is detachably connected with the flow guide pipe body.

3. The acquisition device as set forth in claim 1,

the valve is a push type mechanical valve.

4. The acquisition device as set forth in claim 1,

the liquid specimen is vitreous humor in an eye.

5. The acquisition device as set forth in claim 4,

and the piercing part is provided with a limiting mechanism for limiting the piercing depth.

6. The acquisition device as set forth in claim 1,

the outer surface of the liquid storage pipe is provided with anti-skid stripes.

7. The acquisition device as set forth in claim 1,

the liquid storage pipe is a transparent pipe body.

8. The acquisition device as set forth in claim 7,

and scales are arranged on the liquid storage pipe.

9. The acquisition device as set forth in claim 1,

also comprises a cover which can be detachably covered on the puncturing part.

10. The acquisition device as set forth in claim 1,

the piercing member is a needle cannula.