CN109355185A - A kind of antineoplastic immune cell culture apparatus - Google Patents
A kind of antineoplastic immune cell culture apparatus Download PDFInfo
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- CN109355185A CN109355185A CN201811254896.0A CN201811254896A CN109355185A CN 109355185 A CN109355185 A CN 109355185A CN 201811254896 A CN201811254896 A CN 201811254896A CN 109355185 A CN109355185 A CN 109355185A
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- uterus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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Abstract
The present invention provides a kind of antineoplastic immune cell culture apparatus, more particularly to technical field of cell culture, including incubator, incubator includes cabinet and chamber door, cabinet is equipped with inner cavity, it is interior intracavitary to be placed with several layers culturing rack from top to bottom, inner cavity is divided between multiple cultures by culturing rack, the side of cabinet is successively hinged with the chamber door and glass gear door for the opening that can cover inner cavity from outside to inside, side between each culture is hinged with the cervical orifice of uterus that can cover the opening between culture, cervical orifice of uterus is equipped with the handle that can be used in opening cervical orifice of uterus, adjacent cervical orifice of uterus can pass through fixed axis connection, it is set to connect into an entirety.In the present invention, when taking the culture dish in one of culture, it is only necessary to open corresponding cervical orifice of uterus, and other cervicals orifice of uterus are not switched on, scattering and disappearing for the heat between other cultures can be reduced, when the cervical orifice of uterus between all cultures is required to open, it is set to be opened with an integral form, whole culture dish of placing or take does not influence the operating time.
Description
Technical field
The invention belongs to technical field of cell culture, and in particular to a kind of antineoplastic immune cell culture apparatus.
Background technique
Tumour has become the present mankind and is most difficult to one of disease cured, and culture tumour cell is increased, and there is early stage to send out
The specific function of existing cell carcinogenesis, it is the important of tumour growth that it is the key enzyme for controlling cell carcinogenesis proliferation that tumour cell, which increases,
Factor wants early prevention treatment that tumour is avoided to be formed, it is necessary to precognition Tumor Growth is carried out by cell culture in blood,
It when handling cell, needs to be sent into laboratory and is cultivated, test cell growth course and lesion will use in the process
Cell culture apparatus, existing cell culture apparatus include incubator, and incubator includes cabinet and a chamber door and a glass
Glass keeps off door, Multilayer culture shelf is equipped in the inner cavity of cabinet, when the culture dish on one of culturing rack of taking, by chamber door and glass
Glass gear door is opened, and the heat on other culturing racks also can largely scatter and disappear in this way.
Therefore it is badly in need of a kind of antineoplastic immune cell culture apparatus for being able to solve existing issue.
Summary of the invention
The object of the present invention is to provide a kind of antineoplastic immune cell culture apparatus, between taking one of them described culture
When interior culture dish, it is thus only necessary to corresponding cervical orifice of uterus is opened, and other cervicals orifice of uterus are not switched on, and can reduce the heat between other cultures
Scatter and disappear, when the cervical orifice of uterus between all cultures be required to open when, so that it is opened with an integral form, place or take
Whole culture dishes do not influence the operating time.
The present invention provides the following technical solutions:
A kind of antineoplastic immune cell culture apparatus, including incubator, the incubator include cabinet and chamber door, described
Cabinet be equipped with inner cavity, it is described it is interior it is intracavitary be placed with several layers culturing rack from top to bottom, the inner cavity is divided into more by the culturing rack
Between a culture, the side of the cabinet is successively hinged with the chamber door and glass for the opening that can cover the inner cavity from outside to inside
Glass keeps off door, and the side between each culture is hinged with the cervical orifice of uterus that can cover the opening between the culture, sets on the cervical orifice of uterus
There is the handle that can be used in opening the cervical orifice of uterus, the adjacent cervical orifice of uterus can make it connect into one by fixed axis connection
It is whole.
Preferably, in two adjacent cervicals orifice of uterus, cervical orifice of uterus is equipped with the first pillar, and the one of the fixing axle
End cap is on first pillar and can rotate around first pillar, and the other end is equipped with the first magnetic stripe, described in another
Cervical orifice of uterus is equipped with the first convex block, and first convex block is equipped with the second magnetic stripe, revolves in the fixing axle around first pillar
During turning, first magnetic stripe and second magnetic stripe can be affixed and mutually adsorb fixation.
Preferably, the number of the cervical orifice of uterus is 3, is located in the middle the cervical orifice of uterus equipped with the second pillar, the fixing axle
Middle part be placed on second pillar and can around second pillar rotate, the both ends of the fixing axle are respectively equipped with one
A third magnetic stripe is equipped with second convex block on other two described cervical orifice of uterus, and second convex block is equipped with the 4th magnetic stripe,
The fixing axle in the second pillar rotary course, two third magnetic stripes can simultaneously with two the 4th magnetic
Item is affixed and mutually adsorbs fixation.
Preferably, the side of all culturing racks is connected by connecting plate, and the connecting plate is located remotely from described
On the side of the culturing rack of the opening of chamber, the one side far from the culturing rack of the connecting plate connects the first cylinder
Piston rod, first cylinder are fixed on the inner wall of the inner cavity, and two opposite inner sidewalls of the inner cavity are equipped with sliding slot,
The both ends of the sliding slot are equipped with the first limited block, and the two sides of the culturing rack are equipped with the sliding block that can be slided in the sliding slot,
First cylinder drives the culturing rack to slide along the length direction of the sliding slot by the connecting plate.
Preferably, described interior intracavitary equipped with interior case, the side wall of the interior case is equipped with multiple through-holes, is equipped with institute in the interior case
Culturing rack is stated, the bottom wall of the inner cavity is equipped with sliding rail, and the both ends of the sliding rail are equipped with the second limited block, and the bottom of the interior case is set
There is the pulley that can be slided in the sliding rail, the side wall of the inner cavity is equipped with the second cylinder, and second cylinder is by stretching
Contracting bar connects the interior case, and second cylinder is able to drive the interior case and slides on the sliding rail.
Preferably, cavity is equipped in the side wall of the cabinet, the side wall towards the inner cavity of the cavity is equipped with connection
Hole, the cavity are connected to by the intercommunicating pore with the inner cavity, and the bottom of the cabinet is equipped with accommodating chamber, in the accommodating chamber
Equipped with heating module, humidification module and refrigeration module, the accommodating chamber is connected to the cavity.
The beneficial effects of the present invention are:
When taking the culture dish in one of them described culture, it is thus only necessary to open corresponding cervical orifice of uterus, and other cervicals orifice of uterus
Be not switched on, can reduce other culture between heat scatter and disappear, when the cervical orifice of uterus between all cultures be required to open when, make its with
One integral form is opened, and whole culture dish of placing or take does not influence the operating time.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.In the accompanying drawings:
Fig. 1 is structural schematic diagram of the invention；
Fig. 2 is that the adjacent cervical orifice of uterus equipped with the first magnetic stripe and the second magnetic stripe of the invention is connected as whole schematic diagram；
Fig. 3 is the schematic diagram of the adjacent cervical orifice of uterus separation in Fig. 2；
Fig. 4 is the schematic diagram that three cervicals orifice of uterus equipped with third magnetic stripe and the 4th magnetic stripe of the invention are linked together；
Fig. 5 is the schematic diagram that the first cylinder drives culturing rack movement；
Fig. 6 is the structural schematic diagram of the corresponding inner cavity Fig. 5；
Fig. 7 is the structural schematic diagram of case movement in the second cylinder drives.
Wherein in the figure, it is marked as 1, cabinet；2, chamber door；3, inner cavity；4, culturing rack；5, between cultivating；6, glass keeps off door；7, sub
Door；8, handle；9, fixing axle；10, the first pillar；11, the first magnetic stripe；12, the first convex block；13, the second magnetic stripe；14, second is convex
Column；15, third magnetic stripe；16, the second convex block；17, the 4th magnetic stripe；18, connecting plate；19, the first cylinder；191, piston rod；20, sliding
Slot；21, sliding block；22, interior case；23, through-hole；24, pulley；25, sliding rail；26, the second cylinder；27, telescopic rod；28, accommodating chamber；
29, cavity；30, heating module；31, humidification module；32, refrigeration module；33, intercommunicating pore；34, culture dish.
Specific embodiment
As shown in figs. 1-7, a kind of antineoplastic immune cell culture apparatus, including incubator, incubator include 1 He of cabinet
Chamber door 2, cabinet 1 are equipped with inner cavity 3, are placed with several layers culturing rack 4 from top to bottom in inner cavity 3, it is more that culturing rack 4, which divides inner cavity 3,
5 between a culture, the side of cabinet 1 is successively hinged with the chamber door 2 and glass gear door 6 for the opening that can cover inner cavity 3 from outside to inside,
Between each culture 5 side be hinged with can cover culture between 5 opening cervical orifice of uterus 7, cervical orifice of uterus 7 be equipped with can be used in open son
The handle 8 of door 7, adjacent cervical orifice of uterus 7 can be connected by fixing axle 9, it is made to connect into an entirety.
Specifically, a cervical orifice of uterus 7 is equipped with the first pillar 10, and an end cap of fixing axle 9 exists in two adjacent cervicals orifice of uterus 7
It can rotate on first pillar 10 and around the first pillar 10, the other end is equipped with the first magnetic stripe 11, another cervical orifice of uterus 7 is equipped with the
One convex block 12, the first convex block 12 are equipped with the second magnetic stripe 13, in fixing axle 9 in 10 rotary course of the first pillar, the first magnetic
Item 11 and the second magnetic stripe 13 can be affixed and mutually adsorb fixation.This is a kind of adjacent cervical orifice of uterus 7 to be fixed into an entirety
Mode rotates fixing axle 9 when needing to open a cervical orifice of uterus 7, so that the first magnetic stripe 11 and the separation of the second magnetic stripe 13, then do not have
There is the connection of fixing axle 9, which can individually open, and when the cervical orifice of uterus 7 to be again switched off, fix by rotation
Axis 9 under magneticaction, fixes fixing axle 9 so that the first magnetic stripe 11 and the second magnetic stripe are affixed and mutually adsorb fixation, from
And adjacent cervical orifice of uterus 7 is made to be connected to an entirety.
Specifically, the number of cervical orifice of uterus 7 is 3, cervical orifice of uterus 7 is located in the middle equipped with the second pillar 14, the middle part of fixing axle 9 covers
In that can rotate on the second pillar 14 and around the second pillar 14, the both ends of fixing axle 9 be respectively equipped with a third magnetic stripe 15, separately
It is equipped with second convex block 16 on outer two cervicals orifice of uterus 7, the second convex block 16 is equipped with the 4th magnetic stripe 17, in fixing axle 9 around the
In two pillars, 14 rotary course, two third magnetic stripes 15 can be affixed with two the 4th magnetic stripes 17 simultaneously and mutually adsorb fixation.
When needing to open a cervical orifice of uterus 7, fixing axle 9 is rotated, so that third magnetic stripe 15 and the separation of the 4th magnetic stripe 17, are not then fixed
The connection of axis 9, three cervicals orifice of uterus 7 can be opened individually, solid by rotating when the cervical orifice of uterus opened 7 to be again switched off
Dead axle 9 under magneticaction, fixes fixing axle so that third magnetic stripe 15 and the 4th magnetic stripe 17 are affixed and mutually adsorb fixation
9, so that three cervicals orifice of uterus 7 are connected to an entirety.
Want early prevention treatment that tumour is avoided to be formed, it is necessary to carry out precognition tumour growth mistake by cell culture in blood
Journey needs to be sent into laboratory and is cultivated when handling cell, test cell growth course and lesion, needs in incubation
Medical worker rocks 34 inner cell of culture dish, allows cell homoepitaxial, but the inevitable strength of manual operation is uneven, to it
Checked operation causes error afterwards.In view of this, can improve by the following two kinds mode, automatic shaking is realized:
The first is that as shown in Figure 5 and Figure 6, the side of all culturing racks 4 is connected by connecting plate 18, connecting plate 18
In on the side of the culturing rack 4 of the opening far from inner cavity 3, the one side of the separate culturing rack 4 of connecting plate 18 connects the first cylinder
19 piston rod 191, the first cylinder 19 are fixed on the inner wall of inner cavity 3, and two opposite inner sidewalls of inner cavity 3 are equipped with sliding slot
20, the both ends of sliding slot 20 are equipped with the first limited block, and the two sides of culturing rack 4 are equipped with the sliding block 21 that can be slided in sliding slot 20, the
One cylinder 19 by connecting plate 18 drive culturing rack 4 along the chute 20 length direction sliding.This is a kind of side that culturing rack 4 is mobile
One of formula, the first cylinder 19 drive connecting plate 18 for linear motion so that culturing rack 4 along the chute 20 length direction make it is straight
Line movement allows cell homoepitaxial so that the cell in culture dish 34 thereon is rocked.
Second is as shown in fig. 7, being equipped with interior case 22 in inner cavity 3, and the side wall of interior case 22 is equipped with multiple through-holes 23, interior case 22
Interior to be equipped with culturing rack 4, the bottom wall of inner cavity 3 is equipped with sliding rail 25, and the both ends of sliding rail 25 are equipped with the second limited block, and the bottom of interior case 22 is set
There is the pulley 24 that can be slided in sliding rail 25, the side wall of inner cavity 3 is equipped with the second cylinder 26, and the second cylinder 26 passes through telescopic rod
27 connect interior case 22, and the second cylinder 26 is able to drive interior case 22 and slides on sliding rail 25.Second cylinder 26 drive interior case 22 along
Sliding rail 25 is for linear motion so that the culturing rack 4 in it moves, and then the cell in the culture dish 34 on culturing rack 4 into
Row rocks, and allows cell homoepitaxial.
In the present embodiment, cavity 29 is equipped in the side wall of cabinet 1, the side wall towards inner cavity 3 of cavity 29 is equipped with connection
Hole 33, cavity 29 are connected to by intercommunicating pore 33 with inner cavity 3, and the bottom of cabinet 1 is equipped with accommodating chamber 28, are equipped with heating in accommodating chamber 28
Module 30, humidification module 31 and refrigeration module 32, accommodating chamber 28 are connected to cavity 29.Heat, cold air and the moisture of generation can
It to enter in cavity 29, is then entered in inner cavity 3 by intercommunicating pore 33, and then adjusts 34 institute of culture dish on culturing rack 4
The environment temperature at place.
Principle
When culture dish 34 in 5 between take one of culture, it is thus only necessary to open corresponding cervical orifice of uterus 7, and other cervicals orifice of uterus 7
Be not switched on, can reduce other culture between 5 heat scatter and disappear, when between all cultures 5 cervical orifice of uterus 7 be required to open when take
All culture dish 34 or when placing all culture dishes 34, does not influence the operating time, for example, placing training to empty incubator
When supporting ware 34, entire cervical orifice of uterus 7 (can be connected, eventually by the connection of fixing axle 9 since adjacent cervical orifice of uterus 7 passes through fixing axle 9
All cervicals orifice of uterus 7 are made to connect into an entirety by multiple fixing axles 9), then open together, it being capable of quick culture dish holding
34, if more fan doors 7 not instead of integral form is opened, culture dish holding 34 is opened in batches, will increase placement in this way
Time, or do not formed one it is whole and fully open when, due to cervical orifice of uterus 7 be it is hinged, may move, influence to place, when
When opening with an entirety, whole cervical orifice of uterus 7 can be fixed by the hand or body of experimenter, avoid influencing to put
Culture dish 34 is set, to accelerate the speed of culture dish holding 34 to a certain extent, that is, compared with no cervical orifice of uterus 7, not shadow
Ring the operating time.All fixing axles 9 of cervical orifice of uterus 7 are fixed in normal use, when needing to open one of cervical orifice of uterus 7,
It is first turned on a fixing axle 9, so that the cervical orifice of uterus 7 is separated from other cervicals orifice of uterus 7, it is then by handle 8 that it is independent
It opens, the cervical orifice of uterus 7 and other cervicals orifice of uterus 7 is fixed into an entirety after closing cervical orifice of uterus 7, then by fixing axle 9.
These are only the preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to the foregoing embodiments
Invention is explained in detail, for those skilled in the art, still can be to foregoing embodiments institute
The technical solution of record is modified or equivalent replacement of some of the technical features.It is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of antineoplastic immune cell culture apparatus, which is characterized in that including incubator, the incubator include cabinet and
Chamber door, the cabinet are equipped with inner cavity, it is described it is interior it is intracavitary be placed with several layers culturing rack from top to bottom, the culturing rack will be described interior
Chamber is divided between multiple cultures, and the side of the cabinet is successively hinged with the described of the opening that can cover the inner cavity from outside to inside
Chamber door and glass keep off door, and the side between each culture is hinged with the cervical orifice of uterus that can cover the opening between the culture, described
Cervical orifice of uterus is equipped with the handle that can be used in opening the cervical orifice of uterus, and the adjacent cervical orifice of uterus can make its company by fixed axis connection
It is connected into an entirety.
2. antineoplastic immune cell culture apparatus according to claim 1, which is characterized in that described in adjacent two
In cervical orifice of uterus, a cervical orifice of uterus is equipped with the first pillar, and an end cap of the fixing axle on first pillar and can surround
The first pillar rotation, the other end are equipped with the first magnetic stripe, another described cervical orifice of uterus is equipped with the first convex block, first convex block
It is equipped with the second magnetic stripe, in the fixing axle in the first pillar rotary course, first magnetic stripe and described second
Magnetic stripe can be affixed and mutually adsorb fixation.
3. antineoplastic immune cell culture apparatus according to claim 1, which is characterized in that the number of the cervical orifice of uterus is
It 3, is located in the middle the cervical orifice of uterus and is equipped with the second pillar, be placed on second pillar and can enclose in the middle part of the fixing axle
It is rotated around second pillar, the both ends of the fixing axle are respectively equipped with a third magnetic stripe, on other two described cervical orifice of uterus
Equipped with second convex block, second convex block is equipped with the 4th magnetic stripe, rotates in the fixing axle around second pillar
In the process, two third magnetic stripes can be affixed with two the 4th magnetic stripes simultaneously and mutually adsorb fixation.
4. antineoplastic immune cell culture apparatus according to claim 1, which is characterized in that all culturing racks
Side connected by connecting plate, the connecting plate is located remotely from the side of the culturing rack of the opening of the inner cavity, institute
The one side far from the culturing rack for stating connecting plate connects the piston rod of the first cylinder, and first cylinder is fixed in described
On the inner wall of chamber, two opposite inner sidewalls of the inner cavity are equipped with sliding slot, and the both ends of the sliding slot are equipped with the first limited block, institute
The two sides for stating culturing rack are equipped with the sliding block that can be slided in the sliding slot, and first cylinder drives institute by the connecting plate
The length direction that culturing rack is stated along the sliding slot slides.
5. antineoplastic immune cell culture apparatus according to claim 1, which is characterized in that described interior intracavitary equipped with interior
Case, the side wall of the interior case are equipped with multiple through-holes, and the culturing rack is equipped in the interior case, and the bottom wall of the inner cavity, which is equipped with, to be slided
Rail, the both ends of the sliding rail are equipped with the second limited block, and the bottom of the interior case is equipped with the pulley that can be slided in the sliding rail,
The side wall of the inner cavity is equipped with the second cylinder, and second cylinder connects the interior case, second cylinder by telescopic rod
The interior case is able to drive to slide on the sliding rail.
6. antineoplastic immune cell culture apparatus according to claim 1, which is characterized in that in the side wall of the cabinet
Equipped with cavity, the side wall towards the inner cavity of the cavity is equipped with intercommunicating pore, the cavity by the intercommunicating pore with it is described
Inner cavity connection, the bottom of the cabinet are equipped with accommodating chamber, and heating module, humidification module and refrigeration mould are equipped in the accommodating chamber
Block, the accommodating chamber are connected to the cavity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811254896.0A CN109355185A (en) | 2018-10-26 | 2018-10-26 | A kind of antineoplastic immune cell culture apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811254896.0A CN109355185A (en) | 2018-10-26 | 2018-10-26 | A kind of antineoplastic immune cell culture apparatus |
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| CN109355185A true CN109355185A (en) | 2019-02-19 |
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| CN201811254896.0A Pending CN109355185A (en) | 2018-10-26 | 2018-10-26 | A kind of antineoplastic immune cell culture apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112662556A (en) * | 2021-01-07 | 2021-04-16 | 赵福新 | Automatic cell culture device capable of reducing cell pollution |
| CN113106061A (en) * | 2021-05-07 | 2021-07-13 | 恩大细胞基因工程有限公司 | Method for long-term storage and recovery culture of single cells |
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Application publication date: 20190219 |