CN109350704A - 一种基于延胡索治疗幽门管溃疡的中药丸剂 - Google Patents
一种基于延胡索治疗幽门管溃疡的中药丸剂 Download PDFInfo
- Publication number
- CN109350704A CN109350704A CN201811539724.8A CN201811539724A CN109350704A CN 109350704 A CN109350704 A CN 109350704A CN 201811539724 A CN201811539724 A CN 201811539724A CN 109350704 A CN109350704 A CN 109350704A
- Authority
- CN
- China
- Prior art keywords
- grams
- ulcer
- pyloric canal
- corydalis tuber
- corydalis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种基于延胡索治疗幽门管溃疡的中药丸剂，其特征在于各中药原料的重量组成为：延胡索18克、水红花子24克、炒香附15克、赤包12克、两面针15克、合欢皮12克、秫米12克、连翘6克、八月札6克、白芍6克和苍术9克。
Description
技术领域
本发明涉及一种基于延胡索治疗幽门管溃疡的中药丸剂，属中医中药技术领域。
背景技术
幽门管溃疡多由于神经、内分泌调节功能发生紊乱，破坏了粘膜屏障而形成。本发明所治疗的是肝胃郁热型幽门管溃疡，也是临床最常见的类型；幽门管溃疡是指幽门括约肌至幽门口长2--4厘米的一段管道，发生在幽门管内的溃疡；其临床症状比较明显，且容易发生梗阻，与普通型胃溃疡有很大差别。
发明内容
本发明的目的是提供一种基于延胡索治疗幽门管溃疡的中药丸剂，具有见效快、疗程短、治愈率高、安全方便、无毒副作用的特点。
本发明所述的治疗幽门管溃疡的中药丸剂，各中药原料的重量组成为：延胡索18克、水红花子24克、炒香附15克、赤包12克、两面针15克、合欢皮12克、秫米12克、连翘6克、八月札6克、白芍6克和苍术9克。
制备方法：将上药炮制合格、称量配齐，共轧为细粉，和匀、过100目细罗，用冷开水将药粉泛为小丸，晒干或低温烘干，装袋，每袋重10克。
用法及用量：口服，一次一袋，日服三次，30天为一疗程。
本发明中的药物机理如下：
延胡索：化湿行气；温中止呕；开胃消食。。
水红花子：散血、消积、止痛，多用于胃痛及腹胀痞块等。
炒香附：理气解郁、调经止痛。
赤包：理气活血止痛、祛瘀、止呕。
两面针：祛风活络、散瘀止痛、解毒消肿。
合欢皮：安神解郁、活血消肿，有很好的疏肝解郁、悦心安神的功效。
秫米：和胃安眠。
连翘：疏风清热、清热解毒、消痈散结。据报道，本品有广谱抗菌作用，对幽门螺旋杆 菌有抑制作用。
八月札：疏肝理气、散结。
白芍：敛阴止汗、平肝止痛、养血调经。
苍术：燥湿健脾、祛风湿。
本发明以延胡索、水红花子为主药，炒香附、赤包为辅助药，两面针、合欢皮、秫米、连翘、八月札、白芍、苍术共为佐使药。
以上诸药的主治及功效均参考于中医药院校本科教材《中药学》。
以下为临床试验总结：临床试验治疗幽门管溃疡患者600例。
幽门管溃疡的症状：胃脘部灼热疼痛、食后加重，嘈杂泛酸、口干口苦，烦躁易怒，大便秘 结，舌红苔黄、脉弦数。
治疗方案：服用实施例丸剂，一次一袋，日服三次，30天为一疗程。
治疗标准：
痊愈上腹部不适等症状全部消失，胃镜复查溃疡面已愈合。
好转上腹部不适等症状明显减轻，胃镜复检溃疡面积缩小。
无效临床症状减轻，胃镜检查无明显好转。
治疗结果：幽门管溃疡患者经过一个疗程治疗后痊愈540例，占90%，好转48例，占8%，无效16例，占2%，总有效率98%。通过治疗所示，对病人无任何副作用，三大常规化验及肝肾功能检测未发现异常。
以下列举几个典型病例：
病例1：患者常某，男，53岁，生活无规律、有吸烟饮酒史，近年来突感胃脘部胀痛、食后疼痛加重，泛酸，心烦易怒，口苦、咽干。2017年11月，确诊为幽门管溃疡， 给予本发明药物治疗一个疗程后症状全部消失，复查溃疡已愈合。
病例2：患者刘某某，男，63岁，长期上腹部不适、疼痛、反酸、嗳气，食后疼痛加重、口苦咽干。2018年1月，检查确诊为幽门管溃疡，口服本发明药物治疗一个疗程后症状消失，检查溃疡已消失。
病例3：患者邓某某，男，33岁，长期上腹部不适，两年前曾在省立医院诊为幽门管溃疡， 多方治疗均未治愈。近半年来自感症状加重，上腹部饱胀、疼痛、嗳气、吞酸、烦躁，因在 家治疗无效，2017年5月，复查诊为幽门管溃疡，给予本发明药物治疗一个疗程后 症状全部消失，复查溃疡已愈合。
本发明药物临床使用表明有如下优点：
①本发明所选用的中草药均符合《中华人民共和国药典》规定，根据配伍，本发明具有泄热和胃、疏肝止痛的功效。
②本发明不仅对幽门管溃疡具有很好的治疗作用，而且对萎缩性胃炎、十二指肠球部溃疡也 有明显的治疗效果。
③本发明辩证准确、配伍合理，用药精良、标本兼治。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例
中药原料的重量组成为：延胡索18克、水红花子24克、炒香附15克、赤包12克、两面针15克、合欢皮12克、秫米12克、连翘6克、八月札6克、白芍6克和苍术9克。
制备方法：将上药炮制合格、称量配齐，共轧为细粉，和匀、过100目细罗，用冷开水 将药粉泛为小丸，晒干或低温烘干，装袋，每袋重10克。口服，一次一袋，日服三次，30 天为一疗程。
Claims (2)
1.一种基于延胡索治疗幽门管溃疡的中药丸剂，其特征在于各中药原料的重量组成为：延胡索18克、水红花子24克、炒香附15克、赤包12克、两面针15克、合欢皮12克、秫米12克、连翘6克、八月札6克、白芍6克和苍术9克。
2.如权利要求1所述的方法，其特征在于，所述采集数据，根据采集的所述数据确定生产配方剂量。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811539724.8A CN109350704A (zh) | 2018-12-17 | 2018-12-17 | 一种基于延胡索治疗幽门管溃疡的中药丸剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811539724.8A CN109350704A (zh) | 2018-12-17 | 2018-12-17 | 一种基于延胡索治疗幽门管溃疡的中药丸剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109350704A true CN109350704A (zh) | 2019-02-19 |
Family
ID=65328960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811539724.8A Pending CN109350704A (zh) | 2018-12-17 | 2018-12-17 | 一种基于延胡索治疗幽门管溃疡的中药丸剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109350704A (zh) |
-
2018
- 2018-12-17 CN CN201811539724.8A patent/CN109350704A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101129723A (zh) | 治疗便秘的一种中药制剂 | |
| CN105456897A (zh) | 一种含有艾叶的治疗脾虚胃弱型慢性胃炎的中药组合物 | |
| CN101721667A (zh) | 一种治疗消化不良的中药 | |
| CN101129766A (zh) | 一种治疗便秘的中药制剂 | |
| CN101342282B (zh) | 一种治疗胃病的中药组合物及制备方法 | |
| CN104306618A (zh) | 一种治疗鼻炎的中药组合物及其制备方法 | |
| CN109350704A (zh) | 一种基于延胡索治疗幽门管溃疡的中药丸剂 | |
| CN109394988A (zh) | 一种基于川乌治疗高位胃溃疡的中药丸剂 | |
| CN109602863A (zh) | 一种基于延胡索治疗慢性胃肠炎的中药丸剂 | |
| CN109224001A (zh) | 一种基于乌药治疗多发性胃溃疡的中药丸剂 | |
| CN109288982A (zh) | 一种基于丹参治疗复合性胃溃疡的中药丸剂 | |
| CN109125632A (zh) | 一种基于乌药治疗多发性胃溃疡的中药丸剂 | |
| CN109331123A (zh) | 一种治疗慢性肠炎的中药丸剂 | |
| CN109316562A (zh) | 一种治疗慢性肠炎的中药丸剂 | |
| CN109381655A (zh) | 一种基于白豆蔻治疗胰源性胃溃疡的中药丸剂 | |
| CN109350700A (zh) | 一种治疗慢性胃炎的中药丸剂 | |
| CN109453312A (zh) | 一种基于吴茱萸治疗巨大性胃溃疡的中药丸剂 | |
| CN109224035A (zh) | 一种治疗胃溃疡的中药丸剂 | |
| CN105125789A (zh) | 治疗胃痛的健脾和胃制剂及制备方法 | |
| CN103638355B (zh) | 治疗胃溃疡的中药丸剂 | |
| CN103550734B (zh) | 一种治疗慢性支气管炎的中药汤剂 | |
| CN103100042A (zh) | 治疗肝胃郁热型慢性胃炎的中药制剂 | |
| CN101940643B (zh) | 一种治疗胃癌、食道癌的药物 | |
| CN102961662B (zh) | 一种治疗胃溃疡的药物及其制备方法 | |
| CN101224295A (zh) | 一种治疗消化系统肿瘤的中药组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190219 |