CN109350555A - A kind of reparation skin recombination human source collagen freeze-drying ball and preparation method thereof - Google Patents
A kind of reparation skin recombination human source collagen freeze-drying ball and preparation method thereof Download PDFInfo
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- CN109350555A CN109350555A CN201811498279.5A CN201811498279A CN109350555A CN 109350555 A CN109350555 A CN 109350555A CN 201811498279 A CN201811498279 A CN 201811498279A CN 109350555 A CN109350555 A CN 109350555A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
A kind of reparation skin recombination human source collagen freeze-drying ball and preparation method thereof, uses shell unit analog cellular aluminium；It repeats finite element honeycomb aluminum and forms preceding anticollision honeycomb aluminum energy absorbent block and rear main body honeycomb aluminum energy absorbent block；The flowing of airbag unit simulated air is established in honeycomb aluminum；Establish installation Slab and honeycomb aluminum skin finite element model；Above structure is binded to form obstacle model by glue unit；Establish the vehicle frame model of movable counterguard；Obstacle model is fixed on vehicle frame model by mounting plate, defines the coefficient of friction of the contact relation and each contact surface inside and out honeycomb aluminum energy absorbent block；Obstacle parameter used in actual collision measurement condition is substituted into model, obstacle model needed for establishing is added whole vehicle model, the collision Finite Element Simulation Analysis of corresponding operating condition is carried out using the obstacle.The finite element modeling method of obstacle provided by the present invention can greatly improve the accuracy of the finite element model of obstacle, optimize the computational accuracy and efficiency of obstacle operating condition.
Description
Technical field
The present invention relates to cosmetic fields, especially relate to a kind of reparation skin recombination human source collagen freeze-drying
Ball and preparation method thereof.
Background technique
Teenager's face acnes when faulty restoration, easily form acne hole, tubercle, to artificial at psychological pressure when serious.It wipes
Wound is scalded in face, it is also desirable to good repairing quality and quickly reparation speed.
With the development of biotechnology, new biological products such as recombination human source collagen, epidermal growth factor are largely gushed
In present cosmetics.Recombination human source collagen is that the tripeptides based on type III collagen a1 chain collagen domain Gly-X-Y repeats
Sequence signature obtains pichia yeast genetic engineering bacteria fermentation by gene recombination technology, cell exocrine type destination protein,
It has characteristics that
(1) low immunogenicity: according to human collagen sequence construct, and the tryptophan etc. for having caused immune response is replaced.
(2) virus-free hidden danger: animal sources collagen, which has, carries the hidden danger such as avian influenza virus, crazy heifer disease virus, foot and mouth disease virus.It should
Recombined collagen ferments from yeast, therefore the albumen obtained will not carry exogenous virus.(3) good water solubility, easily suction
It receives.(4) it easily absorbs, detects that recombination human source collagen is easily perforated through cuticula by X-ray microdiffraction technology.(5) it helps
It repairs, test cell line proves, can promote keratinocyte cell migration, helps to repair.It is examined simultaneously by X-ray microdiffraction technology
It surveys, it is found that the order arrangement of the lipid of recombination human source collagen Stratum Corneum, ordering are arranged with the effect of being obviously promoted, to table
Skin skin repairs aesthetics, and there are positive effects.Isolated skin test display, can increase collagen content in skin, recombined human
Skin material is turned in the collagen of source, is had clear improvement to quality after reparation.
But recombination human source collagen, in liquid preparation, active evanescence needs rationally to save.Therefore one is needed
Kind lyophilized preparation, can keep the activity of biological product very well.
Summary of the invention
The purpose of the present invention will solve above-mentioned technical problem, provide a kind of reparation skin recombination human source collagen freeze-drying
Ball and preparation method thereof.
The object of the present invention is achieved like this: a kind of reparation skin recombination human source collagen freeze-drying ball, feature
Be, in percentage by weight, formula include following components: recombination human source collagen 25-35%, hyaluronic acid 5-10%,
Trehalose 3-5%, mannitol 10-15%, Aureobasidium pullulans polysaccharide 45-55%, oligopeptides -1(1000-1500U/), oligopeptides -5
(1000-1500U/).
As a preferred technical scheme: the recombination human source collagen freeze-drying ball is as shown in SEQ ID NO: 1
Amino acid sequence composition, contain 599 amino acid, molecular weight 55.0KDa.
As a preferred technical scheme: the hyaluronic acid is the hyaluronic acid (ten thousand molecular weight of 20-40) of middle-molecular-weihydroxyethyl.
As a preferred technical scheme: the oligopeptides -1, oligopeptides -5 are without containing glycerol etc. to be not easy that ingredient is lyophilized, and are free of
Hygroscopicity salinity.
As a preferred technical scheme: the recombination human source collagen freeze-drying ball is placed in solvent to be used after dissolution.
As a preferred technical scheme: the solvent includes glycerol 3%, butanediol 4%, hyaluronic acid (130-210 ten thousand
Molecular weight) 0.1%, allantoin 0.1%, water-soluble bisabolol 1%, -5 alcohol 0.5% of O- cymene, niacinamide 2%, BHC 1.0%,
EDTA-2Na 0.05%, water complements to 100%.
A kind of preparation method repaired skin and ball is lyophilized with recombination human source collagen, which is characterized in that including following step
It is rapid:
Step 1: weighing hyaluronic acid, mannitol, trehalose, Aureobasidium pullulans polysaccharide homogeneous and accelerate dissolution, 80 DEG C of heat preservations
15min.Step 2: after above-mentioned solution homogeneous transparent, being cooled to 30 DEG C hereinafter, recombination human source collagen, widow is then added
Peptide -1, oligopeptides -5, adjusting pH are 5-8.Step 3: carrying out 0.22um aseptic filtration, moulding extremely under the conditions of GMP production environment
Diameter is freeze-drying to moisture≤10% after the collagen ball of 1.2cm.Step 4: resulting recombination human source collagen freeze-drying ball is sent
Inspection, it is filling in 50% or less humidity environment after QB/T2660 standard test qualification.
The technical effects of the invention are that:
(1) recombination human source collagen freeze-drying ball can effectively keep the work of recombination human source collagen compared to liquid preparation
Property, guarantee the repairing effect for skin.
(2) recombination human source collagen freeze-drying ball is placed in solvent and is dissolved, solution rate is fast and high-efficient, and solvent
Equally there is reparation whitening function for skin；BHC in solvent is decoyl hydroxyl valeric acid and hexylene glycol is the antibacterial system of compounding；
Glycerol, butanediol, hyaluronic acid are solvent and moisturizing ingredient；Allantoin, water-soluble bisabolol are antiallergic ingredient of releiving；O- umbrella
Flower -5 alcohol of hydrocarbon is fungicide；Niacinamide is whitening and promotion cutin new life ingredient.
(3) recombination human source collagen freeze-drying sphere volume is smaller, is readily transported.
Detailed description of the invention
Fig. 1-Fig. 4 is comparison diagram before and after the present invention is repaired for small pox；
Fig. 5-Fig. 7 is the present invention for the old scar of tumble injury and scalds old scar reparation front and back comparison diagram；
Fig. 8 is the present invention for newly scalding front and back comparison diagram；
Fig. 9 is comparison diagram before and after the present invention is repaired for red capillary；
Figure 10 is 5 grade forms of the embodiment of the present invention 4 and implementation.
Specific embodiment
When specific implementation:
Comparative example 1
Collagen ball formula: recombination human source collagen 25%, ten thousand molecular weight of hyaluronic acid 5%(120), trehalose 5%, mannitol
15%, Aureobasidium pullulans polysaccharide 5%, oligopeptides -1(epithelical cell growth factor, EGF, 1000-1500U/), oligopeptides -5(recombined human
Keratinocyte growth factor, FGF, 1000-1500U/).Weight purified water is supplied to 100%.
Weighing hyaluronic acid, mannitol, trehalose, homogeneous accelerates dissolution, 80 DEG C of heat preservation 15min, to homogeneous transparent,
30 DEG C are cooled to hereinafter, recombination human source collagen, oligopeptides -1, oligopeptides -5 is added, adjusting pH is 5-8.Ring is produced in GMP
0.22um aseptic filtration is carried out under the conditions of border, moulding to collagen bulb diameter is 1.2cm, freeze-drying to moisture≤10%, by resulting object
Expect inspection, it is filling under humidity environment 50%-55% humidity after QB/T2660 standard test qualification.It is filling into cillin bottle, take
1 collagen ball adds 2ml purified water to dissolve, and does not shake, needing 3min or more still has small agglomerate to not readily dissolve.
Embodiment 2
Collagen ball formula: recombination human source collagen 25%, ten thousand molecular weight of hyaluronic acid 5%(20-40), trehalose 5%, mannose
Alcohol 15%, Aureobasidium pullulans polysaccharide 5%, oligopeptides -1(epithelical cell growth factor, EGF, 1000-1500U/), oligopeptides -5(recombination
Human horny cell growth factor-2, FGF, 1000-1500U/).Weight purified water is supplied to 100%.
Weighing hyaluronic acid, mannitol, trehalose, homogeneous accelerates dissolution, 80 DEG C of heat preservation 15min, to homogeneous transparent,
30 DEG C are cooled to hereinafter, recombination human source collagen, oligopeptides -1, oligopeptides -5 is added, adjusting pH is 5-8.Ring is produced in GMP
0.22um aseptic filtration is carried out under the conditions of border, moulding to collagen bulb diameter is 1.2cm, freeze-drying to moisture≤10%, by resulting object
Expect inspection, it is filling under humidity environment 50%-55% humidity after QB/T2660 standard test qualification.It is filling into cillin bottle,
It takes 1 collagen ball that 2ml purified water is added to dissolve, does not shake, 20s can be dissolved to transparent.40 DEG C save 30 days, the contracting of collagen bulb diameter
As low as 0.5cm.
The present embodiment is special to be hyaluronic acid using middle-molecular-weihydroxyethyl (ten thousand molecular weight of 20-40), as a result collagen ball dissolution speed
Degree is fast.
Embodiment 3
Collagen ball formula: recombination human source collagen 25%, ten thousand molecular weight of hyaluronic acid 5%(20-40), trehalose 5%, mannose
Alcohol 15%, Aureobasidium pullulans polysaccharide 5%, oligopeptides -1(epithelical cell growth factor, EGF, 1000-1500U/), oligopeptides -5(recombination
Human horny cell growth factor-2, FGF, 1000-1500U/).Weight purified water is supplied to 100%.
Weighing hyaluronic acid, mannitol, trehalose, homogeneous accelerates dissolution, 80 DEG C of heat preservation 15min, to homogeneous transparent,
30 DEG C are cooled to hereinafter, recombination human source collagen, oligopeptides -1, oligopeptides -5 is added, adjusting pH is 5-8.Ring is produced in GMP
0.22um aseptic filtration is carried out under the conditions of border, moulding to collagen bulb diameter is 1.2cm, freeze-drying to moisture≤10%, by resulting object
Expect inspection, it is filling under humidity environment 35-40% humidity after QB/T2660 standard test qualification.Dissolution is rapid.40 DEG C of preservations
30 days, collagen bulb diameter 1.1-1.2cm, no diminution.
The present embodiment is special be it is filling under humidity environment 35-40% humidity.40 DEG C save 30 days, and collagen ball is without diminution.
Embodiment 4
Collagen ball formula: ten thousand molecular weight of hyaluronic acid 5%(20-40), trehalose 5%, mannitol 15%, Aureobasidium pullulans polysaccharide
5%, oligopeptides -1(epithelical cell growth factor, EGF, 1000-1500U/), oligopeptides -5(recombinant human horny cell growth factor-2,
FGF, 1000-1500U/).Weight purified water is supplied to 100%.
Weighing hyaluronic acid, mannitol, trehalose, homogeneous accelerates dissolution, 80 DEG C of heat preservation 15min, to homogeneous transparent,
30 DEG C are cooled to hereinafter, oligopeptides -1, oligopeptides -5 is added, adjusting pH is 5-8.0.22um is carried out under the conditions of GMP production environment
Aseptic filtration, moulding to collagen bulb diameter are 1.2cm, are lyophilized to moisture≤10%, by resulting material inspection, by QB/T2660
It is filling under humidity environment 35-40% humidity after standard test is qualified.Dissolution rapidly, is not easy to reduce.
Solvent formula: glycerol 3%, butanediol 4%, hyaluronic acid (ten thousand molecular weight of 130-210) 0.1%, allantoin 0.1%, water
Dissolubility bisabolol 1%, -5 alcohol 0.5% of O- cymene, niacinamide 2%, BHC 1.0%, EDTA-2Na 0.05%, water is supplied
100%.Preparation process are as follows: 1, weigh glycerol, hyaluronic acid, allantoin, EDTA-2Na, 80 DEG C of heat preservation 15min are added water to, are stirred
It is dissolved to transparent.2,40 DEG C are cooled to hereinafter, -5 alcohol of O- cymene, the BHC that addition is pre-dissolved with butanediol, are then added nicotinoyl
Amine, water-soluble bisabolol constant volume.
The present embodiment is special to be not aggravating a group human-like collagen in freeze-drying ball.
Embodiment 5
Collagen ball formula: recombination human source collagen 25%, ten thousand molecular weight of hyaluronic acid 5%(20-40), trehalose 5%, mannose
Alcohol 15%, Aureobasidium pullulans polysaccharide 5%, oligopeptides -1(epithelical cell growth factor, EGF, 1000-1500U/), oligopeptides -5(recombination
Human horny cell growth factor-2, FGF, 1000-1500U/).Weight purified water is supplied to 100%.
Weighing hyaluronic acid, mannitol, trehalose, homogeneous accelerates dissolution, 80 DEG C of heat preservation 15min, to homogeneous transparent,
30 DEG C are cooled to hereinafter, recombination human source collagen, oligopeptides -1, oligopeptides -5 is added, adjusting pH is 5-8.Ring is produced in GMP
0.22um aseptic filtration is carried out under the conditions of border, moulding to collagen bulb diameter is 1.2cm, freeze-drying to moisture≤10%, by resulting object
Expect inspection, it is filling under humidity environment 35-40% humidity after QB/T2660 standard test qualification.Dissolution is rapid.40 DEG C of preservations
30 days, collagen bulb diameter 1.1-1.2cm, no diminution.
Solvent formula: glycerol 3%, butanediol 4%, hyaluronic acid (ten thousand molecular weight of 130-210) 0.1%, allantoin 0.1%, water
Dissolubility bisabolol 1%, -5 alcohol 0.5% of O- cymene, niacinamide 2%, BHC 1.0%, EDTA-2Na 0.05%, water is supplied
100%.Preparation process are as follows: 1, weigh glycerol, hyaluronic acid, allantoin, EDTA-2Na, 80 DEG C of heat preservation 15min are added water to, are stirred
It is dissolved to transparent.2,40 DEG C are cooled to hereinafter, -5 alcohol of O- cymene, the BHC that addition is pre-dissolved with butanediol, are then added nicotinoyl
Amine, water-soluble bisabolol constant volume.
The present embodiment is special to be to add 25% recombination human source collagen in freeze-drying ball.
Effect example: recruit 40 volunteers, predominantly moderate small pox person or scratch, scratch, it is small scald etc..It is divided into 2 groups,
Every group of 20 people.1 group uses 4 product of embodiment, and 1 group uses 5 product of embodiment, early daily with solvent 1 ball of dissolution to 3-4ml
Evening is respectively with 1 time.To guarantee that the maximum vigor state of biotic factor uses.Using marking of being taken pictures and evaluated in 5-60 days, respectively
It scores repairing quality, reparation speed, full marks 10 divide.Table is shown in Figure 10
Attached drawing: effect example represents in embodiment 5
Fig. 1-Fig. 4, volunteer's small pox significantly reduce, and cheat after reparation without acne, and whole pore attenuates, and the colour of skin is fine and smooth, become clear.Fig. 5-
The old scar of Fig. 7, respectively tumble injury and the old scar of scald (6-12 month old scars), it can be seen that scar color is obviously thin out, lofty property
It reduces.Fig. 8 is new scald, falls scar within healing rate 7 days, textured after healing naturally, repairing quality is relatively satisfactory.Fig. 9 is red capillary
Apparently it is substantially reduced.
The above embodiment of the present invention is only to clearly demonstrate examples of the invention, but be not limited to this hair
Bright protection scope, all equivalent technical solutions also belong to scope of the invention, and scope of patent protection of the invention should be by each
Item claim limits.
Claims (7)
1. ball is lyophilized with recombination human source collagen in a kind of reparation skin, which is characterized in that in percentage by weight, formula packet
It includes following components: recombination human source collagen 25-35%, hyaluronic acid 5-10%, trehalose 3-5%, mannitol 10-15%, going out
Bud pullulan 45-55%, oligopeptides -1(1000-1500U/), oligopeptides -5(1000-1500U/).
2. ball is lyophilized with recombination human source collagen in a kind of reparation skin according to claim 1, it is characterised in that: described
Recombination human source collagen freeze-drying ball amino acid sequence shown in SEQ ID NO: 1 form, contain 599 amino
Acid, molecular weight 55.0KDa.
3. ball is lyophilized with recombination human source collagen in a kind of reparation skin according to claim 1, it is characterised in that: described
Hyaluronic acid be middle-molecular-weihydroxyethyl hyaluronic acid (ten thousand molecular weight of 20-40).
4. ball is lyophilized with recombination human source collagen in a kind of reparation skin according to claim 1, it is characterised in that: described
Oligopeptides -1, oligopeptides -5 be without containing glycerol etc. be not easy that ingredient is lyophilized, be free of hygroscopicity salinity.
5. ball is lyophilized with recombination human source collagen in a kind of reparation skin according to claim 1, it is characterised in that: described
Recombination human source collagen freeze-drying ball be placed in solvent dissolve after use.
6. ball is lyophilized with recombination human source collagen in a kind of reparation skin according to claim 5, it is characterised in that: described
Solvent include glycerol 3%, it is butanediol 4%, hyaluronic acid (ten thousand molecular weight of 130-210) 0.1%, allantoin 0.1%, water-soluble red
Bisabol 1%, -5 alcohol 0.5% of O- cymene, niacinamide 2%, BHC 1.0%, EDTA-2Na 0.05%, water supplies 100%.
7. a kind of preparation method repaired skin and ball is lyophilized with recombination human source collagen, which comprises the following steps:
Step 1: weighing hyaluronic acid, mannitol, trehalose, Aureobasidium pullulans polysaccharide homogeneous and accelerate dissolution, 80 DEG C of heat preservations
15min；
Step 2: after above-mentioned solution homogeneous transparent, being cooled to 30 DEG C hereinafter, recombination human source collagen, oligopeptides-is then added
1, oligopeptides -5, adjusting pH are 5-8；
Step 3: 0.22um aseptic filtration is carried out under the conditions of GMP production environment, the collagen ball that moulding to diameter is 1.2cm
Afterwards, it is lyophilized to moisture≤10%；
Step 4: ball inspection is lyophilized in resulting recombination human source collagen, after QB/T2660 standard test qualification, in humidity
50% or less environment is filling.
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| CN201811498279.5A CN109350555A (en) | 2018-12-08 | 2018-12-08 | A kind of reparation skin recombination human source collagen freeze-drying ball and preparation method thereof |
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| CN110433086A (en) * | 2019-09-05 | 2019-11-12 | 广州市玉鑫化妆品有限公司 | A kind of blue silk glue protein freeze-drying ball and preparation method thereof |
| CN110960443A (en) * | 2019-12-26 | 2020-04-07 | 广州领衔生物科技有限公司 | Composition containing recombinant human collagen, freeze-dried material, preparation method of freeze-dried material and cosmetic |
| CN112697651A (en) * | 2020-12-30 | 2021-04-23 | 江苏聚源医疗技术有限公司 | Preservation method for improving stability of freeze-dried ball type liquid wound dressing |
| CN112957274A (en) * | 2021-02-04 | 2021-06-15 | 甘肃天际生物科技有限公司 | Recombinant collagen freeze-dried ball and preparation process thereof |
| CN114259419A (en) * | 2021-12-29 | 2022-04-01 | 河北纳科生物科技有限公司 | Compound composition containing recombinant collagen and preparation method and application thereof |
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| CN117138027A (en) * | 2023-10-30 | 2023-12-01 | 北京岷德生物科技有限公司 | Gel containing epidermal stem cell factor and application of gel in scar repair |
| WO2024045952A1 (en) * | 2022-08-30 | 2024-03-07 | 马应龙大健康有限公司 | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof |
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| CN110433086A (en) * | 2019-09-05 | 2019-11-12 | 广州市玉鑫化妆品有限公司 | A kind of blue silk glue protein freeze-drying ball and preparation method thereof |
| CN110960443A (en) * | 2019-12-26 | 2020-04-07 | 广州领衔生物科技有限公司 | Composition containing recombinant human collagen, freeze-dried material, preparation method of freeze-dried material and cosmetic |
| WO2022072696A1 (en) * | 2020-09-30 | 2022-04-07 | Geltor, Inc. | Compositions comprising combinations of collagen or elastin polypeptides with active ingredients and methods of using same |
| CN112697651A (en) * | 2020-12-30 | 2021-04-23 | 江苏聚源医疗技术有限公司 | Preservation method for improving stability of freeze-dried ball type liquid wound dressing |
| CN112957274A (en) * | 2021-02-04 | 2021-06-15 | 甘肃天际生物科技有限公司 | Recombinant collagen freeze-dried ball and preparation process thereof |
| CN114259419A (en) * | 2021-12-29 | 2022-04-01 | 河北纳科生物科技有限公司 | Compound composition containing recombinant collagen and preparation method and application thereof |
| WO2024045952A1 (en) * | 2022-08-30 | 2024-03-07 | 马应龙大健康有限公司 | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof |
| FR3140545A1 (en) | 2022-10-05 | 2024-04-12 | Technature | Cosmetic composition in the form of dry cleansing beads. |
| EP4349318A1 (en) | 2022-10-05 | 2024-04-10 | Technature | Cosmetic composition in the form of cleansing dry beads |
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| CN116919849A (en) * | 2023-09-15 | 2023-10-24 | 中国科学院华南植物园 | Preparation method and application of transdermal collagen freeze-dried composition |
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