CN1093422C - Kelp product used as tranquilizer and soporific or health tonic and its preparation - Google Patents
Kelp product used as tranquilizer and soporific or health tonic and its preparation Download PDFInfo
- Publication number
- CN1093422C CN1093422C CN99117247A CN99117247A CN1093422C CN 1093422 C CN1093422 C CN 1093422C CN 99117247 A CN99117247 A CN 99117247A CN 99117247 A CN99117247 A CN 99117247A CN 1093422 C CN1093422 C CN 1093422C
- Authority
- CN
- China
- Prior art keywords
- edible ethanol
- kelp
- precipitation
- extract
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a method for preparing kelp products as sedative hypnotic medicines or health-care products. The essential of the present invention is a course for extracting natural effective components having a medical sedative hypnotic function and a health-care function from kelp raw material. The preparation method comprises steps that the kelp raw material is leached with hot water or edible ethanol, and the effective components in the kelp raw material are further separated, refined and purified. The products can be made into tablets, capsules, granules or oral liquid. The kelp products are purely natural products, have an obvious sedative hypnotic function and the efficacy of health food and medicinal value, and can be used as the sedative hypnotic medicines or medicinal health-care products.
Description
The present invention relates to a kind of preparation method that its medicinal health effective ingredient becomes kelp product of from the Thallus Laminariae (Thallus Eckloniae) raw material, extracting.
Thallus Laminariae (Thallus Eckloniae) (Laminaria Japonica Aresch) is the marine product that a kind of people are familiar with, contain polysaccharide, protein, crude fibre, several amino acids and iodine, traditional usage is that shredding is dried or fried in shallow oil soup and take, as normal food or the refrigerant diuresis food or the food that enriches the iodine.
The objective of the invention is to propose a kind of preparation method that can be used as the kelp product of tranquilizer and soporific or health product purposes.
Essence of the present invention is that described preparation method comprises following processing step to the leaching process of the natural constituent that has the medicinal and health-care effect of calming soporific in the Thallus Laminariae (Thallus Eckloniae) raw material:
(1) with the Thallus Laminariae (Thallus Eckloniae) raw material with hot water or edible ethanol lixiviate long enough time after-filtration, obtaining filtrate is crude extract, wherein, water temperature raising degree can be controlled in 50～99 ℃, the alcohol extraction Controllable Temperature is built in 20～60 ℃, described edible ethanol concentration is 20%～55%;
(2) crude extract of gained is concentrated, adding edible ethanol to solution concentration of alcohol (V/V) is 55～90%, makes to produce precipitation, removes supernatant, gets its precipitation extract that is as the criterion;
(3) the further purification of accurate extract is handled:
(3.1) with accurate extract with dissolved in distilled water after, adding edible ethanol to solution concentration of alcohol (V/V) in solution is 30～40%, makes to produce precipitation, the centrifugal precipitation of going is got its supernatant;
(3.2) adding edible ethanol to solution concentration of alcohol (V/V) in above-mentioned supernatant is 50～90%, makes to produce precipitation, its precipitation of centrifuging and taking;
(3.3) with above-mentioned precipitate with concentration (V/V) low 50% edible ethanol cyclic washing the precipitate of final centrifugal gained is dried under vacuum promptly get the final extract that can make this kelp product again more than 2 times.
Said kelp product can be made into tablet, capsule, electuary or oral liquid.The final extract that is about to above-mentioned gained adds suitable additives and makes tablet, electuary or capsule, or said final extract directly is mixed with oral liquid.
Above-mentioned steps (2) and each later step are respectively separation and the further refining purge process to the Thallus Laminariae (Thallus Eckloniae) material effective component.
In step (3.3), described precipitate is advisable for general 3～5 times with described edible ethanol cyclic washing number of times.
In step (1), the Thallus Laminariae (Thallus Eckloniae) raw material can be cleaned, dry, carry out lixiviate again after pulverizing, to improve the leaching rate of Thallus Laminariae (Thallus Eckloniae) effective ingredient.
The present invention adopts modern scientific method, and the pharmaceutical components in the Thallus Laminariae (Thallus Eckloniae) raw material is carried out extraction separation, prepared kelp product safety non-toxic, and the reliable easily row of its preparation method is fit to large-scale production, and free from environmental pollution, cost is low.
This kelp product has the effect of tangible calming soporific, and is natural product, has both had the effect of health food, and medical value is arranged again, can be used as the medicine or the medicinal health product of calming soporific.
This kelp product Traditional Chinese Medicine University Of Guangzhou institute of Chinese materia medica carries out the test of mice sedative-hypnotic effect, result of the test such as following table:
Medicine (this kelp product) is to the influence of mice sleep
| Group | Number of animals (only) | Dosage (ml/kg) | Time for falling asleep (min) | Sleep time (min) | Sleeping number (only) |
| Matched group | 14 | ?- | ?20.32±7.39 | ?26.96±10.55 | ?6 |
| Low dose group | 13 | ?6.7 | ?10.75±6.28 | ?26.0±7.55 | ?12 |
| High dose group | 13 | ?13.4 | ?5,12±2.41 | ?43.53±18.59 | ?12 |
As can be seen from the test results, this kelp product can obviously shorten the mice time for falling asleep under doses, prolongs the mice sleep persistent period.As seen, this kelp product has sedative-hypnotic effect.
Embodiment one
Get Thallus Laminariae (Thallus Eckloniae) 10kg, clean, dry, be ground into fractionlet, add 200kg water, stir 120min at 80 ℃ of following constant temperature; Filter, filtrate is concentrated one times, add 95% (V/V) edible ethanol concentration of alcohol (V/V) to the solution and reach 90%, stir, leave standstill, centrifugal, get its precipitation; With the precipitate dissolved in distilled water, add 95% edible ethanol concentration of alcohol (V/V) to the solution again and reach 35%, stir, leave standstill, centrifugal, discard precipitation, get supernatant; In supernatant, add 95% edible ethanol concentration of alcohol to the solution and reach 90%, stir, leave standstill, centrifugal, taking precipitate, the edible ethanol cyclic washing of reuse 95% 3 times; Precipitate after the washing is dried under vacuum condition to water content≤3%, makes tablet, electuary or capsule by conventional method again, or the gained precipitate directly is deployed into oral liquid.The prepared kelp product of this law is a light brown, and eat 100～2000mg every day, has the good sedative soporific function.
Embodiment two
Get Thallus Laminariae (Thallus Eckloniae) 10kg, cleaning, drying are ground into fractionlet, are 50% edible ethanol solution lixiviate 20 hours with 50kg concentration, 30 ℃ of extraction temperatures; Filter, go to the alcohol back to concentrate filtrate, add concentration and be 95% edible ethanol concentration of alcohol (V/V) to the solution and reach 70%, stir, leave standstill, centrifugal, get its precipitation, with the precipitate dissolved in distilled water, add 95% edible ethanol concentration of alcohol (V/V) to the solution again and reach 30%, stir, leave standstill, centrifugal, discard precipitation, get supernatant; In supernatant, add 95% edible ethanol concentration of alcohol to the solution and reach 80%, stir, leave standstill, centrifugal, taking precipitate, the edible ethanol cyclic washing of reuse 95% 3 times; Under vacuum condition, dry to water content≤3%, make tablet, electuary or capsule by conventional method again, or the gained precipitate directly is deployed into oral liquid.
Claims (3)
1. preparation method as the kelp product of tranquilizer and soporific or health product is characterized in that comprising following processing step:
(1) with the Thallus Laminariae (Thallus Eckloniae) raw material with hot water or edible ethanol lixiviate long enough time after-filtration, obtaining filtrate is crude extract, wherein, water temperature raising degree is controlled at 50～99 ℃, the alcohol extraction temperature is controlled at 20～60 ℃, described edible ethanol concentration is 20%～55%;
(2) crude extract of gained is concentrated, adding edible ethanol to solution concentration of alcohol (V/V) is 55～90%, makes to produce precipitation, removes supernatant, gets its precipitation extract that is as the criterion;
(3) the further purification of accurate extract is handled:
(3.1) with accurate extract with dissolved in distilled water after, adding edible ethanol to solution concentration of alcohol (V/V) in solution is 30～40%, makes to produce precipitation, the centrifugal precipitation of going is got its supernatant;
(3.2) adding edible ethanol to solution concentration of alcohol (V/V) in above-mentioned supernatant is 50～90%, makes to produce precipitation, its precipitation of centrifuging and taking;
(3.3) with above-mentioned precipitate with concentration (V/V) low 50% edible ethanol cyclic washing the precipitate of final centrifugal gained is dried under vacuum promptly get the final extract that can make this kelp product again more than 2 times.
2. by the preparation method of the described kelp product of claim 1, it is characterized in that step (3.3) is 3～5 times to described precipitate with described edible ethanol cyclic washing number of times.
3. by the preparation method of the described kelp product of claim 1, it is characterized in that said kelp product makes tablet, capsule, electuary or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117247A CN1093422C (en) | 1999-11-29 | 1999-11-29 | Kelp product used as tranquilizer and soporific or health tonic and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117247A CN1093422C (en) | 1999-11-29 | 1999-11-29 | Kelp product used as tranquilizer and soporific or health tonic and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1297753A CN1297753A (en) | 2001-06-06 |
| CN1093422C true CN1093422C (en) | 2002-10-30 |
Family
ID=5279883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99117247A Expired - Lifetime CN1093422C (en) | 1999-11-29 | 1999-11-29 | Kelp product used as tranquilizer and soporific or health tonic and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1093422C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106349298A (en) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | Application of sodium alginate oligose and derivative to improvement of sleep disorders |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297277C (en) * | 2004-02-21 | 2007-01-31 | 李文东 | Laminaran granule and its preparation technology |
| CN103338780A (en) * | 2010-12-20 | 2013-10-02 | 韩国食品研究院 | Composition for positively allosterically modulating GABAA-benzodiazepine receptor and composition for producing sedative-hypnotic effects containing ecklonia cava extract and ecklonia kurome extract |
| CN102726647B (en) * | 2012-05-11 | 2013-11-27 | 重庆市中药研究院 | Anti-radiation food and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105540A (en) * | 1994-11-03 | 1995-07-26 | 大连海藻保健食品厂 | Natural plant extracted liquid and its use |
-
1999
- 1999-11-29 CN CN99117247A patent/CN1093422C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105540A (en) * | 1994-11-03 | 1995-07-26 | 大连海藻保健食品厂 | Natural plant extracted liquid and its use |
Non-Patent Citations (1)
| Title |
|---|
| 《中草药》1984,15(12) 1984.12.1 侯敏礼，"海带根药理试验研究" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106349298A (en) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | Application of sodium alginate oligose and derivative to improvement of sleep disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1297753A (en) | 2001-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104473171B (en) | A kind of fiery numb lozenge and preparation method thereof | |
| CN112961260A (en) | Gracilaria lemaneiformis polysaccharide with remarkable anti-inflammatory activity and preparation method and application thereof | |
| CN101066299A (en) | Extracting process and product of tartary buckwheat extract with rich tartary buckwheat flavone | |
| CN114452326A (en) | Exocarpium Citri Grandis extract with cough relieving and phlegm eliminating effects and high yield extraction method | |
| CN1093422C (en) | Kelp product used as tranquilizer and soporific or health tonic and its preparation | |
| Tang et al. | Optimization of the technology of extracting water-soluble polysaccharides from Morus alba L. leaves | |
| KR100775741B1 (en) | A method for the preparation of extract from Angelica gigantis radix and the composition containing the extract | |
| CN111803531A (en) | Preparation method and application of dandelion leaf water-soluble crude extract | |
| CN103275237A (en) | Preparation method and application of eggplant branch polysaccharide | |
| CN107440114B (en) | Composition with PM2.5 particle resistance effect | |
| CN108686012A (en) | A kind of the membrane of a chicken's gizzard preparation and preparation method thereof | |
| KR101119410B1 (en) | Foeniculum vulgar extracts compositions for treating or preventing inflammatory diseases | |
| JPH0519554B2 (en) | ||
| CN111700927B (en) | Medicinal and edible composition with blood sugar reducing effect and preparation method and application thereof | |
| CN1098654C (en) | Kelp product (II) and its production method and application | |
| CN105412613A (en) | Composition for Alzheimer's disease and processing method of composition | |
| KR102290859B1 (en) | Red Ginseng Extract comprising Saponin and high purity Acidic Polysaccarride, Manufacturing method thereof and Healty Food containing the same | |
| CN112971127A (en) | Medlar glycopeptide auxiliary blood pressure lowering oral liquid and preparation method thereof | |
| KR20120086262A (en) | Fraxinus rhynchophylla Hance extracts compositions for treating or preventing inflammatory diseases | |
| CN1090920C (en) | Kelp product and its production method and application | |
| CN110664975A (en) | Preparation method and application of ginger composite extract | |
| CN115381874B (en) | Traditional Chinese medicine composition and granule for treating chicken noninfectious diarrhea and preparation method thereof | |
| CN1204140C (en) | Cistanche saponin and its extraction process | |
| CN101538334B (en) | Method for extracting medicinal large leaf moss polysaccharide | |
| CN1081369A (en) | Extract the preparation method of " raising brain function " medicine with shinyleaf yellowhorn fruit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| C10 | Entry into substantive examination | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HUANLE MARINE BIOTECHNOLOGY DEVELOPMENT CO LTD, GU Free format text: FORMER OWNER: SOUTH-SEA OCEAN INST., CHINE ACADEMY OF SCIENCES Effective date: 20130110 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 510301 GUANGZHOU, GUANGDONG PROVINCE TO: 510175 GUANGZHOU, GUANGDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130110 Address after: 30, No. 303, No. eight, stone road, Zhongshan Road, Liwan District, Guangdong, Guangzhou 510175 Patentee after: Huanle Marine Biotechnology Development Co Ltd, Guangzhou City Address before: 510301 Xingang West Road, Guangdong, China, No. 164, No. Patentee before: South-sea Ocean Inst., Chine Academy of Sciences |
|
| ASS | Succession or assignment of patent right |
Owner name: HUIZHOU JIUHUI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HUANLE MARINE BIOTECHNOLOGY DEVELOPMENT CO LTD, GUANGZHOU CITY Effective date: 20130221 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 510175 GUANGZHOU, GUANGDONG PROVINCE TO: 516007 HUIZHOU, GUANGDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130221 Address after: 516007 No. 199 South Bank Road, Huicheng District, Guangdong, Huizhou Patentee after: Huizhou Jiuhui Pharmaceutical Co., Ltd. Address before: 30, No. 303, No. eight, stone road, Zhongshan Road, Liwan District, Guangdong, Guangzhou 510175 Patentee before: Huanle Marine Biotechnology Development Co Ltd, Guangzhou City |
|
| CX01 | Expiry of patent term |
Granted publication date: 20021030 |
|
| CX01 | Expiry of patent term |