CN109338722A - A kind of preparation process of absorabable hemostatic gauze - Google Patents
A kind of preparation process of absorabable hemostatic gauze Download PDFInfo
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- CN109338722A CN109338722A CN201811237883.2A CN201811237883A CN109338722A CN 109338722 A CN109338722 A CN 109338722A CN 201811237883 A CN201811237883 A CN 201811237883A CN 109338722 A CN109338722 A CN 109338722A
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- gauze
- solution
- reaction
- preparation process
- natural cotton
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- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 38
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229920000742 Cotton Polymers 0.000 claims abstract description 20
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 230000003647 oxidation Effects 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 18
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000004317 sodium nitrate Substances 0.000 claims abstract description 13
- 235000010344 sodium nitrate Nutrition 0.000 claims abstract description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000005406 washing Methods 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 9
- 235000010288 sodium nitrite Nutrition 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 230000004048 modification Effects 0.000 claims abstract description 8
- 238000012986 modification Methods 0.000 claims abstract description 8
- 238000005956 quaternization reaction Methods 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 6
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000005470 impregnation Methods 0.000 claims abstract description 4
- 238000011049 filling Methods 0.000 claims abstract description 3
- 238000007654 immersion Methods 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000013078 crystal Substances 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 238000002386 leaching Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 238000005269 aluminizing Methods 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 abstract description 4
- 230000035484 reaction time Effects 0.000 abstract description 4
- 239000012467 final product Substances 0.000 abstract description 2
- 238000002791 soaking Methods 0.000 abstract description 2
- 238000010828 elution Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 description 27
- 239000001913 cellulose Substances 0.000 description 27
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000000835 fiber Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 5
- 239000007800 oxidant agent Substances 0.000 description 5
- 230000001590 oxidative effect Effects 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- -1 D- glucopyranose acid anhydride Chemical class 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000004627 regenerated cellulose Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 229920006221 acetate fiber Polymers 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- 238000011001 backwashing Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000004388 gamma ray sterilization Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000008104 plant cellulose Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/144—Alcohols; Metal alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
- D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
- D06M11/38—Oxides or hydroxides of elements of Groups 1 or 11 of the Periodic Table
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- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/58—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides
- D06M11/64—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides with nitrogen oxides; with oxyacids of nitrogen or their salts
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- A61L2400/00—Materials characterised by their function or physical properties
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Abstract
The present invention relates to a kind of preparation processes of absorabable hemostatic gauze, it is the following steps are included: (1) modification: the natural cotton gauze of modifying agent thorough impregnation being carried out immersion treatment under normal temperature and pressure environment；(2) basification: the natural cotton gauze of above-mentioned modification is placed in the reaction vessel for filling quaternization liquid, and heat preservation carries out basification；(3) oxidation reaction is handled: in the natural cotton gauze investment sodium nitrate oxidation solution that above-mentioned basification is crossed, sodium nitrite is added and is reacted as catalyst；(4) it neutralizes carrying out washing treatment: the processed natural cotton gauze of above-mentioned oxidation reaction being washed with ethanol water, inorganic acid elution is added to neutrality；(5) it post-processes: isopropanol soaking and washing will be used again after centrifugal dewatering with washed cotton gauze among the above, drying and sterilization treatment to obtain the final product；The technique both improves reaction rate, shortens reaction time, but be greatly improved when clinical use it is instant i.e. stop performance.
Description
Technical field
The invention belongs to the production technologies of medical dressing, and in particular to a kind of preparation process of absorabable hemostatic gauze.
Background technique
Absorabable hemostatic gauze belongs to biological medical polymer biodegradation type material, is by natural plants cotton fiber
It is further processed by physics, chemical means, the aseptic packaging after γ ray sterilization.Oxycellulose is that cellulose spreads out
One kind of biology has the characteristics that biodegradability, good biocompatibility, environmental-friendly and nontoxic, has been used for not
Few industry, especially selective oxidation cellulose.Monocarboxyl cellulose is the product of C6 primary hydroxyl selective oxidations of cellulose,
This selective oxidation cellulose can slowly be absorbed by living tissue, frequently as Absorbable hemostatic material during clinical treatment
It uses.
Cellulose is the stereospecificity high-molecular compound connected by D- glucopyranose acid anhydride by β-Isosorbide-5-Nitrae glycosidic bond,
There are 3 active hydroxyls, i.e. two secondary hydroxyls, one primary hydroxyl in its macromolecular chain on each glucose basic ring.Cellulose is certainly
The most abundant renewable resource in right boundary, can synthesize several hundred billion tons by photosynthesis every year, be maximum a kind of on the earth
Natural polymer.In mankind's pay attention to day by day environmental protection, today of sustainable development is emphasized, cellulose substances cause extensively again again
The interest of big researcher.Multi cellulose derivative has been developed that, and obtains practical application, and such as cellulose acetate sticks
Glue fiber element etc..
Cellulose derivative, such as carboxymethyl cellulose, hydroxyethyl cellulose, because this kind of high molecular biocompatibility,
Biodegradable and non-toxic and make its application range in health industry very extensive.Chemical modification is to obtain this kind of tool
Have specific characteristics can high molecular effective ways.Oxidation reaction, especially targeting selective oxidation reaction, can selective oxidation fibre
Some or certain several hydroxyls on the glucose residue of plain macromolecular basic ring are tieed up, and introduce new functional group in specific position,
Such as carboxyl, aldehyde radical or carbonyl, the oxide of this kind of cellulose causes unique texture that cellulose can be made to have new purposes.
Oxycellulose is one kind of cellulose derivative, has been used for many industries, hospitality industry is such as used for, as medical
Absorabable hemostatic gauze；Substitute for tobacco business, as natural baccy；As photographic paper ion exchange material；It is used as
Prepare the raw material etc. of active carbon.Its another big potential use is: due to introduced in cellulose glucose basic ring carboxyl this
One active group, it is used as oxidized fibre obtained by the intermediate product that cellulose is further modified, especially selective oxidation
Element.
This derivative of cellulose is well known unlike acetate fiber, viscose fiber, main cause
It is, along with the degradation of cellulose macromolecule chain, the property of cellulose macromolecule chain to be made to change during cellulose oxidation,
The cellulose of complete oxidation is water-soluble.
The development of domestic absorabable hemostatic gauze arrives animal derived absorbable hemostatic by earliest nonabsorable hemostatic gauze
Gauze, then arrive plant cellulose absorabable hemostatic gauze commonly used currently on the market.Animality raw material, such as chitosan
Deng because it is easy to generate rejection to human body, and zoonosis may being carried, once repeatedly be asked in clinic
Topic, therefore gradually by market.Existing market be mainly with natural plants regenerated cellulose it is leading, finally organized in vivo
Absorption is decomposed into glucose, and final product is carbon dioxide and water.
According to preparation method disclosed in Chinese patent CN1186490, medical instant hemostatic gauze is by hydroxyethyl cellulose
Manufactured, raw material is medical absorbent cotton/gauze, ethylene oxide etc..By the way that ethylene oxide is added to medical degreasing yarn in low vacuum environment
Cloth carries out chemical modification, introduces the hydrophilic group of hydroxyl, has manufactured soluble hydroxyethyl cellulose --- medical instant hemostatic gauze；
The mild reaction condition, but due to using a large amount of ethylene oxide to make increased risk, while ethylene oxide as oxidant
Though residual quantity is washed, it is also difficult to which guarantee absolutely not substance or molecule are left.It is well known that ethylene oxide is not only toxic,
And it is inflammable and explosive, therefore, although the mild risk of the technique reaction condition is too big, product also has insecurity.
According to preparation method disclosed in Chinese patent CN101284144, S-100 absorbable hemostasia material is a kind of warp
Cross the soluble hemostatic cotton of chemical oxidation treatment.That there is unit areas in clinical use is small, treats in large area burn and scald
When be not available, the non-serviceable disadvantage in surgical wound surface such as gynemetrics's caesarean birth of plane.It can not be in all sections of hospital
Room is general.
According to preparation method disclosed in Chinese patent CN1286329, the product produced is water-soluble stanch fibre, sample
Appearance yellow is presented compared with deep, feel is harder in product.Soluble test is as the result is shown；Conversion reaction is incomplete, still has not after 24 hours
Molten object exists.
The oxidation processes of cellulose are the premises of oxidized regenerated cellulose preparation, are committed step.The choosing of general cellulose
The oxidation of selecting property can be C6, C2 and C3, and can only be selective as the oxycellulose of Medical absorbable hemostatic gauze
Aoxidize its C6.And most basic there are two having is also technical indicator the most main: (1) carboxyl contains in oxycellulose under dry state
Amount is 16% ~ 24%, to guarantee its haemostatic effect；(2) degree of polymerization of oxycellulose is 200 ~ 500, can make oxidation fine in this way
Dimension element can be absorbed by human body, and its fabric can be made to have certain intensity.Therefore, how to accomplish both to have can guarantee that oxidizability reached
Certain value, and can control the degree of polymerization of cellulose macromolecule in a certain range, this is Medical absorbable oxycellulose development
In required solve to be also stubborn problem the most.
Summary of the invention
For disadvantages mentioned above of the existing technology and problem, the present invention provides a kind of preparations of absorabable hemostatic gauze
Technique, the innovative point of the technique are to quote sodium nitrate and sodium nitrite in the oxidation reaction as new oxidant and directional catalyzing
Agent aoxidizes oxidant purposefully for preferred C6 when 3 active hydroxyls aoxidize in cellulose molecular chain.Both
Reaction rate is improved, reaction time is shortened；The experimental results showed that；Carboxyl-content is 23.2% in oxycellulose under dry state,
The degree of polymerization of oxycellulose be 487.8, thus when improving absorabable hemostatic gauze clinical use it is instant i.e. only performance.
The invention adopts the following technical scheme:
The present invention provides a kind of preparation process of absorabable hemostatic gauze, it the following steps are included:
(1) modification: it is small under normal temperature and pressure environment with the natural cotton gauze of modifying agent thorough impregnation to carry out immersion treatment 1.5
When, the weight ratio of the modifying agent and gauze is 4:1；
(2) the natural cotton gauze Jing Guo step (1) modification basification: is placed in the reaction appearance for filling quaternization liquid
In device, keep 23 DEG C -27 DEG C of temperature, reaction vessel are interior to stir 1.5 hours of 18 revs/min of rotation speed lower basifications；
(3) it oxidation reaction: by the investment sodium nitrate oxidation solution of the natural cotton gauze Jing Guo step (2) basification, keeps
Sodium nitrite is added at 28 DEG C -32 DEG C in temperature, reacts 2.5 hours, and the weight ratio of the sodium nitrate solution and gauze is 6.0 ~
7.0:1, the dosage of the sodium nitrite are the 10 ~ 15% of gauze weight；
(4) neutralisation treatment: will treated that natural cotton gauze is washed with acidic ethanol aqueous solution by step (3) oxidation reaction
It neutralizes, until neutralizing cleaning solution pH value is 6.8 ~ 7.2；
(5) it post-processes: the gauze centrifugal dewatering of carrying out washing treatment will be neutralized by step (4), the gauze that centrifugal dewatering obtains first is used
Isopropanol impregnates, then drying and sterilization treatment.
According to the preparation process of above-mentioned absorabable hemostatic gauze, modifying agent described in step (1) is 95%(v/v) ethyl alcohol
Solution.
According to the preparation process of above-mentioned absorabable hemostatic gauze, the preparation of basification reaction solution described in step (2):
Pure crystal is analyzed with sodium hydroxide and purified water is configured to the sodium hydroxide solution of 40wt%, is stirred with glass bar to being completely dissolved,
It places to as clear as crystal, impurity screening, reaction solution is then cooled to 13 DEG C -17 DEG C, is sealed.
According to the preparation process of above-mentioned absorabable hemostatic gauze, the preparation of sodium nitrate solution described in step (3): nitre is used
Sour sodium analyzes pure crystal and purified water is put into container and is stirred with glass bar up to dissolution, places to as clear as crystal, impurity screening,
The oxidation liquid of 60wt% concentration is made, temperature is controlled at 23 DEG C -27 DEG C, is sealed.
According to the preparation process of above-mentioned absorabable hemostatic gauze, ethanol water described in step (4) is 75%(v/v)
Ethanol water.
According to the preparation process of above-mentioned absorabable hemostatic gauze, concentrated acid solution described in step (4) is concentrated hydrochloric acid.
According to the preparation process of above-mentioned absorabable hemostatic gauze, after the completion of washing in step (5), centrifugal dewatering is carried out,
It is separated by solid-liquid separation, with concentration is that 95wt% isopropanol washs 1 hour the gauze separated, makes the quick dehydration of gauze；It then takes out
Drying and processing is carried out at 88 DEG C -92 DEG C after gauze centrifugation, water content is not greater than 8%, then evens up and arrange；After drying
Gauze is cut by customer requirement, is used inner packing as paper and plastics compound bag of aluminizing, outer layer and is put on the compound of PE and leaching membrane paper again
Bag packaging, then does sterilization treatment using the method for 60Co γ-rays irradiation, and irradiation dose 20kGy. obtains absorbable hemostatic
Gauze.
Preparation process of the invention has the advantage that compared with prior art
1, present invention process innovative point is that reference sodium nitrate is used as newly as new oxidant, sodium nitrite in the oxidation reaction
Directional catalyst, be oriented the oxidant hydroxyl that 3 are active in cellulose molecular chain (C6, C2, C3)
It is purposive when oxidation to have selected C6.Both reaction rate is improved, reaction time is shortened.Carboxylic in oxycellulose under dry state
Base content is 23.2%, and the degree of polymerization of oxycellulose is 487.8, and is greatly improved instant i.e. only performance when clinical use.
2, present invention process level is advanced, no environmental pollution；Product Safety is high, and sterile, cell-cytotoxic reaction shows 0
Grade, no allergic reaction, no epithelium stimulation, heavy metal free harm.Validity is accurate, and hemostasis amount is big, anthemorrhagic speed is fast, instant
Molten, PH is in neutrality, use scope is wide, not subsidiary any drug.During every safe mass index is stable, performance quality index reaches
2015 editions relevant regulations of state's pharmacopeia；Product stability is good, and storage is convenient, and price is suitable.Meet three items of green product
Part, degradable absorption, renewable, low-carbon.
3, present invention innovation uses native cellulose for main raw material(s), and modified processing is degreasing and thorough impregnation, alkali
After changing processing and oxidation reaction processing, keep the disordered state of polyhydroxy in natural fiber special as orderly non-polyhydroxy water imbibition
Kind cellulose, to make in the water-soluble solution of modified special fibre element or be dissolved in other aqueous factors.
Specific embodiment
It is now as follows for embodiment in order to which the present invention is better described:
Embodiment 1
The present invention provides a kind of preparation process of absorabable hemostatic gauze, it the following steps are included:
(1) prepare material: the 95%(v/v of 1000 grams of cotton gauze, 4000ml) ethanol solution；
(2) modification: under normal temperature and pressure environment, cotton gauze is packed into glass container, gauze is allowed to scatter as far as possible, should not
Overlapping, then slowly pours into 95%(v/v along glass container wall) ethanol solution, it is tamped with glass bar, soaks gauze completely, then
It is sealed 1 hour with silica gel plug；It shook 2 minutes at interval of 20 minutes；The 95%(v/v) ethanol solution and gauze weight ratio
For 4:1；
(3) hydrogen-oxygen of pure crystal and purified water configuration 40wt% the preparation of quaternization liquid: basification: is analyzed with sodium hydroxide
Change sodium solution 4000ml, is stirred with glass bar to being completely dissolved in as clear as crystal, should be filtered if any impurity, it then will be anti-with ice water
Liquid is answered to be cooled to 25 DEG C, sealing；The natural cotton gauze of modification will be placed in by step (2) and fill quaternization liquid
Reaction vessel in, then be added the configured quaternization liquid of 4000ml, temperature control 25 DEG C, circulation stirring speed be 18
Controlled micro crystallization is carried out under rev/min to handle 1.5 hours；
(4) oxidation reaction is handled: the preparation of sodium nitrate solution: sodium nitrate being analyzed pure crystal 390g and is put into glass beaker container
It is interior, the purified water got ready is slowly poured into 6500ml scale along container inner wall, is stirred with glass bar, 60 can be heated up in stirring
DEG C to accelerate solution rate, stirs to being completely dissolved, make the oxidation liquid of 60wt% concentration；It places in as clear as crystal
When, observation has free from admixture, should filter if any impurity, oxidation liquid temperature should be maintained at 25 DEG C, be sealed；Step will be passed through
(3) in the natural cotton gauze investment sodium nitrate solution of basification, 30 DEG C are maintained the temperature at, being slowly added into dosage is gauze weight
The sodium nitrite of amount 10 ~ 15% is stirred to accelerate to dissolve with glass rod with gentle as catalyst, reaction speed is improved, at 30 DEG C of temperature
2.5 hours of lower progress oxidation reaction；Through oxidation reaction, treated that gauze is mellow and full, and appearance is in yellowish；
(5) neutralize carrying out washing treatment: will be 75%(v/v with concentration by step (4) oxidation reaction treated gauze) ethanol water
Solution is washed, and is measured in washing process with PH and is tried its pH value, carrys out neutralization reaction liquid using concentrated hydrochloric acid when being greater than 8 such as pH value
Nearly 7.0, washing times can be reduced in this way, save wash time；Washing is finally 7.0 to reaction solution pH value, can be weighed as needed
After backwashing is washed for several times；
(6) it post-processes: the gauze for neutralizing carrying out washing treatment by step (5) being subjected to centrifugal dewatering, is separated by solid-liquid separation, separating
Gauze with concentration be 1 hour of 95wt% isopropanol soaking and washing, gauze fast dewatering can be made；After then taking out gauze centrifugation
Drying and processing is done at 90 DEG C 20 minutes, then even up and arrange.Gauze after drying is cut by customer requirement, using interior
Be packaged as aluminizing paper and plastics compound bag, outer layer puts on the complex pocket packaging of PE and leaching membrane paper again, is then irradiated using 60Co γ-rays
Method do sterilization treatment, irradiation dose 20kGy is to get arriving absorabable hemostatic gauze.
It is detected with product prepared by the embodiment of the present invention 1, performance indicator testing result is as follows:
1, mass area ratio 80g/m2
2, gram water absorption 25ml；
3, surfacing is clean, thickness is well-balanced, uniform color, trimming are neat, the defects of without peculiar smell, impurity, spot, breakage；
4, sterile；
5, no cytotoxicity reacts；
6, without sensitivity response；
7, without skin irritatin；
8, pH value: the pH value 7.0 of hemostatic yarn pieces of cloth leaching liquid；
9, content of beary metal: the content of beary metal of hemostatic gauze leaching liquid and blank control, total content≤5 of lead, zinc, tin, iron
μ/ml, content≤0.1 μ/ml of cadmium.
Embodiment 2
The sodium hydroxide solution of 50wt% is selected in basification, other operations are same as Example 1, and acquisition is can absorb
Hemostatic gauze appearance is withered, feel is hardened, color is deeper；Unit area 80g/m2Every gram of water absorption 20ml, other inspections
Result is surveyed with embodiment 1.
Embodiment 3
The sodium nitrate solution of 50wt% is selected in oxidation reaction, other operations are same as Example 1.The absorbable hemostatic yarn of acquisition
The disorder of cloth appearance yarn, feel have knot, uneven color, mass area ratio 76g/ ㎡, every gram of water absorption 22ml, other detection knots
Fruit is the same as example 1.
Embodiment 4
The sodium nitrite of gauze quality 20% is added in oxidation reaction as catalyst, oxidation time can be made to shorten 37 minutes,
Other operations are same as Example 1, the absorabable hemostatic gauze appearance yarn of acquisition is fluffy, feel it is warm and sunny it is soft, color is greyish white；Unit
Area quality 75g/ ㎡, every gram of water absorption 29ml, other testing results are the same as embodiment 1.
Comparative example 1
According to preparation method disclosed in Chinese patent CN1286329A operate, reaction time it is longer, need 10 hours with
On；Secondly, etherification temperature is 75 DEG C when handling the raw material after activation using a halogenated alkyl acid reaction solution, need to heat, and
Method of the invention does not have to heating, can carry out physical reaction processing to gauze by alkalization, oxidation reaction at normal temperature, whole
The time of a process reaction is short, and 5 hours can complete.
Comparative example 2
According to preparation method disclosed in Chinese patent CN1186490, it is added during ethylene oxide that there are certain safety
Hidden danger can form explosive mixture with air because the chemical property of ethylene oxide is very active, therefore, to operation ring
Border requires height, needs to operate in low vacuum environment, in addition, ethylene oxide is such as taken accidentally, is easy to produce the uncontrollable shapes such as explosion
Condition；The material that the method for the present invention manufacturing process is selected is relatively safe, is not easy to cause accident.
Related explanation, in the present invention, all percentage is unit of weight；Chemical reagent used is that analysis is pure；
Equipment and supplementary material can be bought from market.
Above embodiments are only used for being illustrated technical solution of the present invention, rather than to the limit of the scope of the present invention
System.
Although the invention is described in detail with reference to the preferred embodiments, it is therefore an objective to as much as possible make related personnel accurate
Understand.And to the contents of the present invention propose it is new, more preferably suggest or scheme, but the spirit and scope of the invention should not be detached from.
Claims (7)
1. a kind of preparation process of absorabable hemostatic gauze, it is characterised in that it the following steps are included:
(1) modification: it is small under normal temperature and pressure environment with the natural cotton gauze of modifying agent thorough impregnation to carry out immersion treatment 1.5
When, the weight ratio of the modifying agent and gauze is 4:1；
(2) the natural cotton gauze Jing Guo step (1) modification basification: is placed in the reaction appearance for filling quaternization liquid
In device, keep 23 DEG C -27 DEG C of temperature, reaction vessel are interior to stir 1.5 hours of 18 revs/min of rotation speed lower basifications；
(3) it oxidation reaction: by the investment sodium nitrate oxidation solution of the natural cotton gauze Jing Guo step (2) basification, keeps
Sodium nitrite is added at 28 DEG C -32 DEG C in temperature, reacts 2.5 hours, and the weight ratio of the sodium nitrate solution and gauze is 6.0 ~
7.0:1, the dosage of the sodium nitrite are the 10 ~ 15% of gauze weight；
(4) neutralisation treatment: will treated that natural cotton gauze is washed with acidic ethanol aqueous solution by step (3) oxidation reaction
It neutralizes, until neutralizing cleaning solution pH value is 6.8 ~ 7.2；
(5) it post-processes: the gauze centrifugal dewatering of carrying out washing treatment will be neutralized by step (4), the gauze that centrifugal dewatering obtains first is used
Isopropanol impregnates, then drying and sterilization treatment.
2. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that step changes described in (1)
Property agent be 95%(v/v) ethanol solution.
3. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that alkali described in step (2)
Change the preparation of processing reaction solution: analyzing pure crystal with sodium hydroxide and purified water is configured to the sodium hydroxide solution of 40wt%, use glass
Glass stick is stirred to being completely dissolved, and is placed to as clear as crystal, impurity screening, reaction solution is then cooled to 13 DEG C -17 DEG C, sealing is protected
It deposits.
4. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that nitre described in step (3)
The preparation of acid sodium solution: pure crystal is analyzed with sodium nitrate and purified water is put into container and is stirred with glass bar until dissolving, placement
To as clear as crystal, impurity screening, the oxidation liquid of 60wt% concentration is made, temperature is controlled at 23 DEG C -27 DEG C, and sealing is protected
It deposits.
5. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that second described in step (4)
Alcohol solution is 75%(v/v) ethanol water.
6. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that dense described in step (4)
Acid solution is concentrated hydrochloric acid.
7. the preparation process of absorabable hemostatic gauze according to claim 1, which is characterized in that washed in step (5)
Cheng Hou carries out centrifugal dewatering, is separated by solid-liquid separation, and with concentration is that 95wt% isopropanol washs 1 hour the gauze separated, makes yarn
The quick dehydration of cloth；Drying and processing is carried out at 88 DEG C -92 DEG C after then taking out gauze centrifugation, water content is not greater than 8%, then
It evens up and arranges；Gauze after drying is cut by customer requirement, is used inner packing and is covered again for paper and plastics compound bag of aluminizing, outer layer
Then the complex pocket of upper PE and leaching membrane paper packaging does sterilization treatment, irradiation dose using the method for 60Co γ-rays irradiation
20kGy. obtains absorabable hemostatic gauze.
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Application publication date: 20190215 |