CN107281534A - A kind of preparation method of natural bamboo fibres hemostatic gauze - Google Patents
A kind of preparation method of natural bamboo fibres hemostatic gauze Download PDFInfo
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- CN107281534A CN107281534A CN201610224701.2A CN201610224701A CN107281534A CN 107281534 A CN107281534 A CN 107281534A CN 201610224701 A CN201610224701 A CN 201610224701A CN 107281534 A CN107281534 A CN 107281534A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention relates to medical supplies field, and in particular to a kind of preparation method of water-soluble bamboo fibre hemostatic gauze；This method includes pretreatment, alkali reaction, ether reaction, carrying out washing treatment, post processing, totally five processes, simple production process, the method using the production hemostatic gauze that source chemicals species is less and effect particularly degradation effect is more excellent.
Description
Technical field
The present invention relates to medical supplies field, and in particular to a kind of system of water-soluble natural bamboo fibre hemostatic gauze
Make method.
Background technology
With developing rapidly for health care and medical career, the requirement to medical equipment is also gradually to high, essence, beautiful
Depth direction develops.Hospital gauze is a kind of important conventional medical dressing, with usage amount is big, application surface
Wide the characteristics of.But, when being related to surgery, face, gynaecology, scald Deng Ge sections, caused by conventional gauze
Problems and accident there is no method to solve for the moment, and the superinfection of such as surface application aggravates patient's because of dressing
Pain, because the carelessness of medical personnel causes internal organ to leave and brings down a great calamity, and the environment for discarding purulence blood gauze is dirty
Dye etc..Therefore, international medical community and scientific and technical personnel are to find new material painstakingly up to century more than one
As long as.Can be coated with reluctantly as the gelfoam of supplement, gelatin fiber, artificial water-soluble mixing etc.,
Due to it, to be not as hemostatic function not good enough, is exactly that insufficient strength is preferable and can not substitute hospital gauze completely.
In recent years, it was envisaged that producing water-soluble stanch fibre, but still because of complex technical process, the reaction time is long,
Production cost is too high, using raw material it is not safe enough the shortcomings of one fashion hardly possible be applied to practice.Such as Chinese patent
CN1286329 provides a kind of water-soluble stanch fibre and preparation method thereof, still, according to the patent working
The production technology of example 1,3,5,6, it is found that the product produced has fibre agglomerates, jaundice, quality
Harder the shortcomings of, and through soluble test, more than 24 hours still with the presence of insoluble matter；Chinese invention
CN101284144 provides a kind of soluble hemostatic cotton, and it is small to there is usable floor area in actual use, big
The burn and scald section of area can not use, and can not be used in surgical wound surface such as gynemetrics's Cesarean esction of plane
Shortcoming；Chinese patent CN1186490 discloses a kind of hydroxyethyl modified cotton fiber fabric and preparation method thereof, deposits
The danger of blast is easily produced in raw materials for production oxirane, and this raw material has toxicity, largely uses
After, though it is scrubbed, it is also difficult to ensure leaving without this material or molecule completely, cause product to have
The shortcomings of certain insecurity；Patent CN101623512 discloses a kind of making of water-soluble hemostatic gauze
Method, the invention, as raw material, significantly solves above mentioned problem using natural cotton gauze, but according to
So there are a some shortcomings, the cost of manufacture of such as product is higher, product degradation speed is slower.
For the self character of cotton fiber and bamboo fibre, cotton fiber is natural fiber, and good water absorption has it to consolidate
Some advantages having, and the hollow feature of bamboo wood in itself, also do not change after regenerated fiber is processed into, according to
It is old keep it is logical after pore structure, just because of these characteristics, make bamboo fibre in hygroscopicity, wet putting, thoroughly
Gas occupy cotton, fiber crops, hair, silk, first of the big textile fabric of bamboo five；Further, since having one kind inside bamboo
Unique material for being " bamboo a kind of jade ", makes bamboo fiber products have natural antibacterial, antibacterial, sterilization effect；
These characteristics of bamboo fibre in itself obtain different degrees of embodiment in its product.
The content of the invention
In order to further overcome in existing natural cotton fiber hemostatic gauze production process using reagent raw material type compared with
Many, cost is higher and the problem of slower gauze degradation speed, the present invention provide a kind of simple production process,
Raw material is used as using the use natural bamboo fibres that source chemicals species is less and effect particularly degradation effect is more excellent
Hemostatic gauze preparation method, comprise the following steps：
Step 1: pretreatment：Natural bamboo fibres material is modified with ethanol solution under normal temperature and pressure environment
Processing, the weight ratio about 2.5~3 of the ethanol solution and gauze：1；Using bamboo fibre as raw material, make
Ethanol solution is less.
Step 2: alkali reacts：Gauze by pretreatment is placed in the reaction vessel for filling sodium hydrate aqueous solution
In, then handle 1~2 under 20~30 DEG C of temperature, reaction vessel rotary speed is 15~20 revs/min
Individual hour；Reaction condition is gentle, and the reaction time is shorter.
Step 3: ether reacts：By the gauze Jing Guo alkali process with chloroacetic ethanol solution in 25~30 DEG C of temperature
Lower processing 1~2 hour, is warming up to 35~40 DEG C to reaction 2~3 hours, the chloroacetic ethanol solution
With gauze weight ratio about 2~3：1；This step is intersected at using natural cotton fiber as raw material, reduces second
The use of alkene sulfonic acid, and the usage amount of monoxone ethanol solution greatly reduces, and makes follow-up technological operation more
Plus it is easy, greatly reduce production cost.
Step 4: carrying out washing treatment：Gauze after treatment is washed with ethanol water, added in washing process
Enter concentrated hydrochloric acid solution neutralization, be 6.5~7.5 to cleaning solution pH value；
Step 5: post processing：After gauze after carrying out washing treatment is handled through centrifugal dewatering, first with ethanol immersion 12~
16 hours, then plate, cut-parts, packaging and sterilization treatment；Intersect at using natural cotton fiber as original
Material uses alcohol solution dipping using isopropanol immersion, the inventive method, reagent be more easy to obtain and also price more
Plus it is cheap.
Preferably, in the preparation method of described natural bamboo fibres hemostatic gauze in step one ethanol solution concentration
For more than 95% (v/v).
Preferably, sodium hydrate aqueous solution in step 2 in the preparation method of described natural bamboo fibres hemostatic gauze
Concentration is 40~50wt%, reaction solution and gauze weight ratio about 2.5~3:1.
Preferably, monoxone ethanol solution in step 3 in the preparation method of described natural bamboo fibres hemostatic gauze
Concentration be 60~75wt%, described chloroacetic acid solution prepares as follows：Weigh in proportion monoxone,
Ethanol solution, then pours into ethanol solution in monoxone, monoxone alcohol mixture is heated to 45~
80 DEG C, stir to being completely dissolved, be cooled to 20~30 DEG C.
Preferably, in the preparation method of described natural bamboo fibres hemostatic gauze in step 4 ethanol water it is dense
Spend for 75~85% (v/v).
Preferably, in the preparation method of described natural bamboo fibres hemostatic gauze in step 5 ethanol concentration >=
85% (v/v).
Preferably, plate the temperature of processing in the preparation method of described natural bamboo fibres hemostatic gauze in step 5
For 80~100 DEG C.
Preferably, packaging described in the preparation method of described natural bamboo fibres hemostatic gauze uses inner packing for plating
The mode of PE and leaching membrane paper on aluminium paper and plastics compound bag, outer layer jacket.
Preferably, sterilization treatment uses cobalt in step 5 in the preparation method of described natural bamboo fibres hemostatic gauze
The method of 60 gamma-ray irradiations.
Preferably, a kind of preparation method of natural bamboo fibres hemostatic gauze, methods described comprises the steps：
Step 1: pretreatment：Natural bamboo fibres material is modified with ethanol solution under normal temperature and pressure environment
Processing, the weight ratio about 3 of the ethanol solution and gauze：1；
Step 2: alkali reacts：Gauze by pretreatment is placed in the reaction vessel for filling sodium hydrate aqueous solution
In, then handle 1.5 hours under 25 DEG C of temperature, reaction vessel rotary speed is 20 revs/min；
Step 3: ether reacts：Gauze Jing Guo alkali process is located at 25 DEG C of temperature with chloroacetic ethanol solution
Reason 1.5 hours, is warming up to 40 DEG C to reaction 2.5 hours, the chloroacetic ethanol solution and gauze weight
Than being about 3：1；
Step 4: carrying out washing treatment：Gauze after treatment is washed with ethanol water, added in washing process
Enter concentrated hydrochloric acid solution neutralization, be 7.0 to cleaning solution pH value；
Step 5: post processing：After gauze after carrying out washing treatment is handled through centrifugal dewatering, first 15 are soaked with ethanol
Hour, then plate, cut-parts, packaging and sterilization treatment.
The water-soluble hemostatic gauze that the inventive method is obtained is detected, its performance test results is as follows：
Physicochemical property：
1st, mass area ratio is more than 35g/m2。
2nd, every gram of water absorption is more than 7ml.
3rd, surfacing cleaning, well-balanced thickness, uniform color, trimming are neat, without peculiar smell, impurity, dirt
The defects such as stain, breakage.
Chemical property
1st, acid-base value：The pH value of Gauze leaching liquid is 6.5~8.5.
2nd, content of beary metal：The content of the heavy metal of hemostatic yarn pieces of cloth leaching liquid and blank control, lead, zinc,
Total content≤5ppm of tin, iron, content≤0.1ppm of cadmium.
Biological property
1st, Gauze is sterile.
2nd, the cell-cytotoxic reaction of Gauze is not more than 1 grade.
3rd, Gauze is without sensitivity response.
4th, Gauze is without skin irritatin.
The water-soluble hemostatic gauze product of the present invention has good water solubility, salt dissolubility and carries the property of medicine, thus tool
There are excellent physics hemostasis, chemical hemostasis and the triple hemostatic functions of physiological hemostasis.
First, physics stops blooding：When product is with Wound contact, the moisture in blood is first absorbed, makes the concentration of blood
Increase with viscosity, flows decrease, meanwhile, expanded rapidly after product water suction, energy flap coverage, wherein one
Divide and be dissolved into viscous liquid, so as to block capillary end, play a part of hemostasis；
2nd, chemical hemostasis：The soft gelinite azelon of the product formation of dissolving, meets red blood cell and blood platelet
When, absorption and cohesion can be produced to it；
3rd, physiological hemostasis：Product can activate internal clotting factor, promote fibrin ferment formation and produce anastalsis,
Clotting factor is the key factor for activating internal originality blood coagulation system.Therefore, this product is to coagulation function obstacle
Patient has significant hemostatic healing efficacy.
The hemostatic gauze obtained by the inventive method has the following advantages that：
1st, the water-soluble hemostatic gauze direct weighting for obtaining the present invention is not required to incidentally any medicine in the surface of a wound,
Can stop blooding rapidly, anti-inflammatory, can also prevent surgical adhesions.Clinic through a large amount of zooperies and various big hospital
Checking, product hemostasis of the invention is rapid, that is, paste it is instant i.e. only, effect is obvious, safe and reliable, to body
It is non-stimulated, no cytotoxicity reaction and side effect.
2nd, product can be used for diffusivity oozing of blood and the veinlet bleeding of various surgical wound surfaces, favourable wound site
Accelerate rehabilitation, it is especially pronounced to disturbances of blood coagulation person's haemostatic effect.
3rd, the pH value of product is non-stimulated to organizing in neutrality, will not cause neurotrosis.
4th, product of the invention it is pure white it is pure, can solubility is high, Bc is good, final decomposable asymmetric choice net in vivo
Into monose, can gradually it be absorbed by the body (general 5~7 days).
5th, product storage is convenient, and stability is good, and its application is related to extensively, available for general outer, orthopaedics, burning
All kinds of surgery hands such as wound, shaping, uropoiesis, oral cavity, ear nose larynx, anal intestine, gynaecology, neurosurgery, tumour
The hemostasis of art, and the first aid field such as daily shield wound, natural calamity, traffic accident and army's field operation.
6th, cost of material of the present invention is cheap, supplies unimpeded, can reuse repeatedly, three wastes generation, production equipment
Simply, percent defective is almost close to zero.
Herein of particular note is that：The inventive method is using bamboo fibre as raw material than using cotton fiber
As raw material, partially due to difference of two kinds of fibrous raw materials on nature, such as：It is fine from cotton fiber and bamboo
For the self character of dimension, cotton fiber is natural fiber, and good water absorption has its some intrinsic advantage, and
The hollow feature of bamboo wood, the staff for adding the present invention in itself finds out the technique side come in experimentation
Method, does not also change after regenerated fiber is processed into, and the structure of logical rear pore is still kept, just because of this
A little characteristics, make bamboo fibre occupy the weaving greatly of cotton, fiber crops, hair, silk, bamboo five in hygroscopicity, wet putting, gas permeability
First of fiber；Further, since having a kind of unique material for being " bamboo a kind of jade " inside bamboo, make bamboo fibre
Product has natural antibacterial, antibacterial, sterilization effect；These characteristics of bamboo fibre in itself are in its product
Obtain different degrees of embodiment.
Also, the researcher of the present invention gropes by technique, and a kind of most of technique is worked out finally only to be made
Ethanol solution single solvent is used, the difference of concentration is only in that；And whole process reaction condition is gently,
There is no any three wastes that pollution is produced to environment；Production cost is saved to a certain extent；
It is experimentally confirmed, the present invention is one very big with being also had using cotton fiber as hemostatic gauze made from material
Advantage be：Using dissolution velocity of the hemostatic gauze made from this method in water significantly faster than using natural
Hemostatic gauze made from cotton fiber, so in surgical procedure, can further reduce the adhesion of gauze, greatly
The big compliance for improving patient.
The gauze obtained using the inventive method is obtained with prior art using natural cotton fiber as raw material
Gauze carries out degradation experiment in water, under the conditions of 37 DEG C of temperature environment, and two kinds of size phases are taken respectively
Same gauze, is 2CM*3CM, is respectively placed in the 50ml aqueous solution, reaches and be completely dissolved, i.e. naked eyes
Precipitation flocculent substance can not be seen, 18 seconds hemostatic gauze used times 5 point obtained using the inventive method, contrast
Product spend time for 10 points 20 seconds.In above-mentioned contrast experiment, the product obtained using the inventive method
The time spent compared to contrast product degraded substantially reduces half, constitutes the production of the inventive method acquisition
Product are compared with the prior art difference huge in product technology feature to achieve the technique effect of uniqueness.
Embodiment
With reference to embodiment, the present invention is described in further detail, and following examples are the solutions to the present invention
Release and the invention is not limited in following examples.
Embodiment 1：
A kind of method for manufacturing water-soluble gauze as raw material using natural bamboo fibres is present embodiments provided, is had
Body includes following five steps：
Step one：Gauze is pre-processed：
Prepare material：95% (v/v) ethanol solution of 1200 grams of natural bamboo fibres material, 4500ml.
Pretreatment：Natural bamboo fibres material is loaded in glass container, allows gauze to try one's best and scatters, should not be overlapping,
Then ethanol is slowly poured into along glass container wall, is tamped with glass bar, gauze is soaked completely.
Step 2：Gauze basification：
With alkaline reaction solution：40wt% sodium hydroxide solution 4800ml is prepared with sodium hydroxide and water, is used
Glass bar is stirred to being completely dissolved in as clear as crystal, and reaction solution then is cooled into 20 DEG C, sealing with cold water
It is standby.
Gauze raw material by pretreatment is placed in circulation rotating reactor, matching somebody with somebody for 3600ml is then added
The alkali reaction solution made, fiber is carried out in the case where 20~30 DEG C of temperature, circulation rate is 20 revs/min
Basification 1.5 hours.
Step 3：Gauze ether reaction treatment：
Prepare reaction solution：The monoxone ethanol for preparing 70wt% with monoxone and 95% (v/v) ethanol is molten
Liquid 1500ml, is put into container and is stirred with glass bar, 50 DEG C can be heated up in stirring to accelerate dissolution velocity,
Stirring is to being completely dissolved in as clear as crystal, and reacting liquid temperature is controlled at 20~30 DEG C, seals standby.
1500ml reaction solution is poured into the gauze container by alkali reaction treatment, located at 27 DEG C of temperature
1.5 hours are managed, 37 DEG C of reactions is warming up to and (amounts to 4 hours) to terminating.Through the yarn after ether reaction treatment
Cloth is mellow and full, and outward appearance is in slightly yellow.
Step 4：The carrying out washing treatment of gauze
Gauze after ether reaction treatment is washed with concentration for 80% (v/v) ethanol water, washed
During test its acid-base value with pH meter, and with concentrated hydrochloric acid come neutralization reaction liquid, washing to reaction solution pH
Final value is 7.
Step 5：Gauze is post-processed
After the completion of washing, centrifugal dewatering is carried out, separation of solid and liquid is 90% the gauze concentration separated
(v/v) ethanol soaks 15 hours, can make gauze fast dewatering.Gauze is then taken out to dry after 90 DEG C
Under do pressing processing.Gauze after pressing is cut by customer requirement, is used inner packing and is answered for paper of aluminizing
Close bag, outer layer puts PE again and the mode of leaching membrane paper is packed, the method then irradiated using 60Co γ-rays
Sterilization treatment is done, water-soluble hemostatic gauze is obtained.
The water-soluble hemostatic gauze that the present embodiment is obtained is detected, its performance test results is as follows：
1st, mass area ratio 90g/m2；2nd, every gram of water absorption 15ml；3rd, surfacing is clean, thick
Thin well-balanced, uniform color, trimming are neat, without defects such as peculiar smell, impurity, spot, breakages；4th, nothing
Bacterium；5th, no cytotoxicity reacts；6th, without sensitivity response；7th, without skin irritatin；8th, acid-base value：Only
PH value=7.1 of blood Gauze leaching liquid；9th, content of beary metal：Lead, zinc, tin, iron total content≤
5ppm, content≤0.1ppm of cadmium.
The hemostatic gauze 2CM*3CM obtained by this method is taken, is placed in the 50ml aqueous solution, is reached completely molten
Solution, i.e. naked eyes can not see precipitation flocculent substance, the hemostatic gauze used time 5 obtained using the inventive method
Divide 18 seconds；And the contrast product bought on the market takes the gauze of same size and in identical experiment
Under the conditions of, reach be completely dissolved time of cost for 10 points 20 seconds.
Embodiment 2
40wt% sodium hydroxide solution is selected in the reaction of gauze basification, other operations and the phase of embodiment 1
Together.The water-soluble hemostatic gauze mass area ratio 90g/m of acquisition2, every gram of water absorption 20ml, other inspections
Survey result be the same as Example 1.
Embodiment 3
75wt% monoxone ethanol solution is selected in the reaction of gauze ether, other operations are same as Example 1.
The water-soluble hemostatic gauze mass area ratio 75g/m of acquisition2, every gram of water absorption 28ml, other testing results
Be the same as Example 1.
Furthermore, it is necessary to illustrate, the specific embodiment described in this specification, it reacts title, raw material
Named title etc. can be different.The equivalent or simple change that all principles according to described in inventional idea of the present invention are done,
In the protection domain for being included in patent of the present invention.Those skilled in the art can be to institute
The specific embodiment of description is made various modifications or supplement or substituted using similar mode, as long as not inclined
From the present invention structure or surmount scope defined in the claims, all should belong to the present invention protection
Scope.
Claims (10)
1. a kind of preparation method of natural bamboo fibres hemostatic gauze, it is characterised in that：Methods described includes following
Step：
Step 1: pretreatment：Natural bamboo fibres material is modified with ethanol solution under normal temperature and pressure environment
Processing, the weight ratio about 2.5~3 of the ethanol solution and gauze：1；
Step 2: alkali reacts：Gauze by pretreatment is placed in the reaction vessel for filling sodium hydrate aqueous solution
In, then handle 1~2 under 20~30 DEG C of temperature, reaction vessel rotary speed is 15~20 revs/min
Hour；
Step 3: ether reacts：By the gauze Jing Guo alkali process with chloroacetic ethanol solution in 25~30 DEG C of temperature
Lower processing 1~2 hour, is warming up to 35~40 DEG C to reaction 2~3 hours, the chloroacetic ethanol solution and yarn
Cloth weight ratio about 2~3：1；
Step 4: carrying out washing treatment：Gauze after treatment is washed with ethanol water, added in washing process
Enter concentrated hydrochloric acid solution neutralization, be 6.5~7.5 to cleaning solution pH value；
Step 5: post processing：After gauze after carrying out washing treatment is handled through centrifugal dewatering, first with ethanol immersion 12~
16 hours, then plate, cut-parts, packaging and sterilization treatment.
2. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
The concentration of ethanol solution is more than 95% (v/v) in the step one.
3. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
Sodium hydrate aqueous solution concentration is 40~50wt% in the step 2, and the weight ratio of reaction solution and gauze is about
2.5~3:1.
4. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
The concentration of monoxone ethanol solution is 60~75wt% in the step 3, and described chloroacetic acid solution is by following
Method is prepared：Monoxone, ethanol solution are weighed in proportion, then pour into ethanol solution in monoxone, will
Monoxone alcohol mixture is heated to 45~80 DEG C, stirs to being completely dissolved, is cooled to 20~30 DEG C.
5. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
The concentration of ethanol water is 75~85% (v/v) in the step 4.
6. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
Concentration >=85% (v/v) of ethanol in the step 5.
7. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
Plated in the step 5 processing temperature be 80~100 DEG C.
8. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
The packaging uses inner packing for the mode of PE and leaching membrane paper on paper and plastics compound bag of aluminizing, outer layer jacket.
9. the preparation method of natural bamboo fibres hemostatic gauze according to claim 1, it is characterised in that：
Sterilization treatment uses the method that 60Co γ-rays are irradiated in the step 5.
10. a kind of preparation method of natural bamboo fibres hemostatic gauze, it is characterised in that：Methods described includes following
Step：
Step 1: pretreatment：Natural bamboo fibres material is modified with ethanol solution under normal temperature and pressure environment
Processing, the weight ratio about 3 of the ethanol solution and gauze：1；
Step 2: alkali reacts：Gauze by pretreatment is placed in the reaction vessel for filling sodium hydrate aqueous solution
In, then handle 1.5 hours under 25 DEG C of temperature, reaction vessel rotary speed is 20 revs/min；
Step 3: ether reacts：Gauze Jing Guo alkali process is located at 25 DEG C of temperature with chloroacetic ethanol solution
Reason 1.5 hours, is warming up to 40 DEG C to reaction 2.5 hours, the chloroacetic ethanol solution and gauze weight ratio
About 3：1；
Step 4: carrying out washing treatment：Gauze after treatment is washed with ethanol water, added in washing process
Enter concentrated hydrochloric acid solution neutralization, be 7.0 to cleaning solution pH value；
Step 5: post processing：After gauze after carrying out washing treatment is handled through centrifugal dewatering, first 15 are soaked with ethanol
Hour, then plate, cut-parts, packaging and sterilization treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610224701.2A CN107281534A (en) | 2016-04-11 | 2016-04-11 | A kind of preparation method of natural bamboo fibres hemostatic gauze |
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| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
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| CN101623512A (en) * | 2009-08-13 | 2010-01-13 | 黄艇 | Production method of water-soluble hemostatic gauze |
| CN102926189A (en) * | 2012-10-26 | 2013-02-13 | 常州市盛辉药业有限公司 | Fabrication method of water-soluble hemostatic gauze |
| CN103120802A (en) * | 2012-07-26 | 2013-05-29 | 佛山市优特医疗科技有限公司 | Soluble hemostatic gauze and preparation methods thereof |
| WO2014096843A2 (en) * | 2012-12-20 | 2014-06-26 | Convatec Technologies Inc. | Processing of chemically modified cellulosic fibres |
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| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
| CN1507843A (en) * | 2002-12-17 | 2004-06-30 | 中山生物工程有限公司 | Process for producing water-soluble hemostatic etamine |
| CN101623512A (en) * | 2009-08-13 | 2010-01-13 | 黄艇 | Production method of water-soluble hemostatic gauze |
| CN103120802A (en) * | 2012-07-26 | 2013-05-29 | 佛山市优特医疗科技有限公司 | Soluble hemostatic gauze and preparation methods thereof |
| CN102926189A (en) * | 2012-10-26 | 2013-02-13 | 常州市盛辉药业有限公司 | Fabrication method of water-soluble hemostatic gauze |
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Application publication date: 20171024 |