CN109331217A - Styptic sponge and its preparation process - Google Patents
Styptic sponge and its preparation process Download PDFInfo
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- CN109331217A CN109331217A CN201811478635.7A CN201811478635A CN109331217A CN 109331217 A CN109331217 A CN 109331217A CN 201811478635 A CN201811478635 A CN 201811478635A CN 109331217 A CN109331217 A CN 109331217A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0061—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof characterized by the use of several polymeric components
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
- C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
- C08J9/142—Compounds containing oxygen but no halogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0058—Biocides
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Abstract
A kind of styptic sponge and its preparation process of field of medical article technology, comprising the following steps: S1, carboxymethyl chitosan is added into deionized water, obtains carboxymethyl chitosan polymer solution;Chitosan is added into carboxymethyl chitosan polymer solution, obtains mixed with polymers solution;S2, green-tea extract powder is added into mixed with polymers solution, is uniformly mixed, adds glycerol foaming, calcium chloride solution is added after foaming and promotes chitosan and carboxymethyl chitosan crosslinking, obtains cross-linked polymer solution;S3, the cross-linked polymer solution is freeze-dried, styptic sponge, last shear forming are obtained.Styptic sponge produced by the present invention has very strong water swelling ability, can stop blooding rapidly, wound healing curative effect.
Description
Technical field
The present invention relates to a kind of technology of field of medical products, specifically a kind of styptic sponge and its preparation process.
Background technique
In military and common people's wound, bleeding is to lead to personnel death's one of the main reasons, after bleeding profusely, except high
Outside medical expense, blood transfusion may cause blood coagulation disorders, the complication such as infection and organ failure.Therefore, timely hemostatic treatment goes out
Blood wound is for reducing blood loss, improving survival rate and realizing that optimal rehabilitation is particularly important.The postmortem of the war in Iraq and Afghanistan
Report shows that effective hemostatic treatment can avoid nearly 24% war death.Hemostatic material can obviously reduce amount of bleeding, Shang Yuanke
Self rescue wins the more time for anaphase.
In order to avoid wound infection, material also needs to possess good antibacterial activity while having anthemorrhagic performance.Chitosan
It is a kind of naturally occurring cationic polysaccharide, has a certain amount of positive charge, can promote erythrocyte aggregation and increase blood platelet
It adheres to and stops blooding.In addition, it also has antibacterial, wound healing performance.However, chitosan does not have in neutral aqueous solution
Solubility property, foam performance is poor, generally requires to be dissolved in acid solution, so that it is restricted its anti-microbial property,
Chitosan needs glutaraldehyde cross-linking just to can get styptic sponge, these processes easily impact environment, and remaining aldehydes is crosslinked
Agent is also easy to produce toxicity.
Summary of the invention
The present invention In view of the above shortcomings of the prior art, proposes a kind of styptic sponge and its preparation process, passes through
The crosslinking of chitosan and water-soluble carboxymethyl chitosan avoids the use of acidic organic solvent and aldehyde crosslinking agent, ensure that
It the anti-microbial property of chitosan and is good for the environment;Styptic sponge obtained has very strong water swelling ability, can stop blooding rapidly,
Wound healing curative effect.
The present invention is achieved by the following technical solutions:
The present invention relates to a kind of preparation processes of styptic sponge, comprising the following steps:
S1, carboxymethyl chitosan is added into deionized water, dissolution completely, obtains carboxymethyl chitosan polymer solution;
Chitosan is added into carboxymethyl chitosan polymer solution, is uniformly mixed, obtains mixed with polymers solution;In parts by weight,
Chitosan is 0.1-0.5 parts in the mixed with polymers solution, and carboxymethyl chitosan is 1-5 parts, and deionized water is 10-100 parts;
S2, the green-tea extract powder of 0.1-0.5 parts by weight is added into mixed with polymers solution, is uniformly mixed, then plus
Enter the foaming of plasticizer glycerol, calcium chloride solution is added after foaming and promotes chitosan and carboxymethyl chitosan crosslinking, is handed over
Linked polymer solution;
S3, the cross-linked polymer solution is freeze-dried, styptic sponge, last shear forming are obtained.
The present invention relates to a kind of styptic sponge, including chitosan-carboxymethyl chitosan complex matrix and it is attached to described multiple
The green-tea extract on matrix is closed, is made using above-mentioned preparation process.
Technical effect
Compared with prior art, the present invention has the following technical effect that
1) present invention introduces carboxymethyl chitosan in chitosan, exists in chitosan and carboxymethyl chitosan strand
More active group, wherein active group amino and carboxyl easily pass through interaction and form compound polyelectrolyte, so that shell
Glycan and carboxymethyl chitosan strand can carry out cross-linking reaction in the case where no-aldehyde crosslinking agent is added, and generate network knot
Structure;The cavernous body of excellent combination property can be prepared under mild conditions, the introducing of no aldehyde crosslinking agent, there is no need
The problem of wanting harmful crosslinking agent such as remaining formaldehyde in a large amount of solvent processing cavernous bodies, solves chitosan in neutral aqueous solution
It can not dissolve, the problem that foam performance is poor, and asking for chitosan anti-bacteria can be inhibited using acid leach solution chitosan
Topic;
2) bacteriostasis of chitosan and carboxymethyl chitosan is limited, therefore introduces master of the green-tea extract as styptic sponge
Want antimicrobial component;Green-tea extract has very strong killing bacterium and prevention infection ability, can protect wound from further
Physical injury and adventive pollution;And chitosan and carboxymethyl chitosan glycopolymers provide safety for green-tea extract
Barrier, green-tea extract, which is directly incorporated into polymer, is still able to maintain original activity, and preparation process is simple, and production cost is low;
3) prices of raw materials are cheap, sponge softness high resilience obtained, have very strong water swelling ability, can be rapidly
Hemostasis, and there is antibacterial, wound healing curative effect, the good bactericidal haemostatic of energy is suitable for the medical fields such as trauma hemostasis.
Detailed description of the invention
Fig. 1 is the FTIR spectrogram of green-tea extract powder in embodiment 1;
Fig. 2 is the FTIR spectrogram of styptic sponge in embodiment 1.
Specific embodiment
The present invention will be described in detail With reference to embodiment.
The present embodiments relate to a kind of preparation processes of styptic sponge, comprising the following steps:
S1, carboxymethyl chitosan is added into deionized water, dissolution completely, obtains carboxymethyl chitosan polymer solution;
Chitosan is added into carboxymethyl chitosan polymer solution, is uniformly mixed, obtains mixed with polymers solution;In parts by weight,
Chitosan is 0.1-0.5 parts in the mixed with polymers solution, and carboxymethyl chitosan is 1-5 parts, and deionized water is 10-100 parts;
S2, the green-tea extract powder of 0.1-0.5 parts by weight is added into mixed with polymers solution, is uniformly mixed, then plus
Enter glycerol foaming, the solution for completing foaming is placed in 10 × 10cm plastic culture dish, adds calcium chloride solution and promote shell poly-
Sugar and carboxymethyl chitosan crosslinking, obtain cross-linked polymer solution;
S3, freeze-drying, acquisition styptic sponge, last shear forming.
In parts by weight, it is preferable that chitosan is 0.1-0.3 parts in the mixed with polymers solution, carboxymethyl chitosan
It is 1-3 parts, deionized water is 10-60 parts.
In parts by weight, it is preferable that the green-tea extract powder additional amount is 0.1-0.3 parts.
Preferably, the foamed time is no more than 60min, the volume and mixed with polymers solution weight of the glycerol for addition of foaming
Amount is than being 1ml:105.5g.
The solution concentration range of the calcium chloride solution is 1%~20%;Preferably, the solution of the calcium chloride solution is dense
Spending range is 1%~15%.
The styptic sponge is disinfected after shear forming through UV, and the wave-length coverage of UV light is in the UV disinfection
365nm, disinfecting time 30min.
The green-tea extract powder is made by the steps to obtain:
1) it is mixed in the ratio of dry green tea and deionized water weight ratio 1:10,30min mixing is continuously stirred at 80 DEG C
Uniformly;It is cooled to room temperature later, adds 300ml dehydrated alcohol, stand for 24 hours, obtain the green tea for being mixed with green tea residue
Extract solution;2 removal green tea residues are refiltered, green-tea extract solution is obtained;
2) for 24 hours in -80 DEG C of freezing green-tea extract solution, then freeze drier is placed in -45 DEG C of freeze-drying 48h, obtain
To green-tea extract solid, then crush to obtain green-tea extract powder.
Embodiment 1
The present embodiment is related to a kind of preparation process of styptic sponge, comprising the following steps:
S1, 5g carboxymethyl chitosan is added into 100g deionized water, dissolution completely, obtains carboxymethyl chitosan glycopolymers
Solution;0.5g chitosan is added into carboxymethyl chitosan polymer solution, is uniformly mixed, obtains mixed with polymers solution;
S2, 0.2g green-tea extract powder is added into mixed with polymers solution, is uniformly mixed, adds 1ml glycerol hair
30min is steeped, the calcium chloride solution that 5ml solution concentration 1% is added after foaming promotes chitosan and carboxymethyl chitosan crosslinking,
Obtain cross-linked polymer solution;
S3, the cross-linked polymer solution is placed under -20~-80 DEG C of environment for 24 hours, takes out and is lyophilized immediately for 24 hours later,
Styptic sponge is obtained, last shear forming is simultaneously sterilized using UV, is stored in later spare in 37 DEG C of drying box.
Green-tea extract powder described in the present embodiment is prepared using following steps:
1) it is mixed in the ratio of dry green tea and deionized water weight ratio 1:10,30min mixing is continuously stirred at 80 DEG C
Uniformly;It is cooled to room temperature 20~30 DEG C later, adds 300ml dehydrated alcohol, stands for 24 hours, acquisition is mixed with green tea residual
The green-tea extract solution of object;2 removal green tea residues are filtered by filter paper or filter again, it is molten to obtain green-tea extract
Liquid;
2) for 24 hours in -80 DEG C of freezing green-tea extract solution, then freeze drier is placed in -42 DEG C of freeze-drying 48h, obtain
To green-tea extract solid, then crush to obtain green-tea extract powder.
500-4000cm is measured using FTIR spectrum-1The light transmission of green-tea extract powder and styptic sponge in wave-number range
Degree, is analyzed;Fig. 1 is the FTIR spectrogram that green tea extracts product, in 2900cm-1Locating absorption peak indicates the stretching of free hydroxyl group
Vibration, 3500cm-1Locating absorption peak indicates asymmetry N-H key and midplane extrusion in amino, shows that green-tea extract has successfully been obtained
Powder;And the FTIR spectrogram of Fig. 2 styptic sponge is in 2900 and 3500cm-1Between be able to observe that it is corresponding with absorption peak in Fig. 1
Two characteristic peaks, show that green-tea extract is loaded successfully into styptic sponge.
It is emphasized that: the above is only presently preferred embodiments of the present invention, not make in any form to the present invention
Limitation, any simple modification, equivalent change and modification to the above embodiments according to the technical essence of the invention,
All of which are still within the scope of the technical scheme of the invention.
Claims (8)
1. a kind of preparation process of styptic sponge, which comprises the following steps:
S1, carboxymethyl chitosan is added into deionized water, dissolution completely, obtains carboxymethyl chitosan polymer solution;To carboxylic first
Chitosan is added in base enclosure chitosan polymer solution, is uniformly mixed, obtains mixed with polymers solution;In parts by weight, described poly-
Closing chitosan in object mixed solution is 0.1-0.5 parts, and carboxymethyl chitosan is 1-5 parts, and deionized water is 10-100 parts;
S2, the green-tea extract powder of 0.1-0.5 parts by weight is added into mixed with polymers solution, is uniformly mixed, adds plasticising
The foaming of agent glycerol is added calcium chloride solution and promotes chitosan and carboxymethyl chitosan crosslinking, obtains cross-linked polymeric after foaming
Object solution;
S3, the cross-linked polymer solution is freeze-dried, styptic sponge, last shear forming are obtained.
2. the preparation process of styptic sponge according to claim 1, characterized in that in parts by weight, the mixed with polymers
Chitosan is 0.1-0.3 parts in solution, and carboxymethyl chitosan is 1-3 parts, and deionized water is 10-60 parts;Preferably, chitosan is
0.1 part, carboxymethyl chitosan is 2 parts, and deionized water is 50 parts.
3. the preparation process of styptic sponge according to claim 1, characterized in that in parts by weight, the green-tea extract
Powder addition is 0.1-0.3 parts, it is preferable that is 0.1 part.
4. the preparation process of styptic sponge according to claim 1, characterized in that the foamed time is no more than 60min, hair
The volume and mixed with polymers solution weight ratio for steeping the glycerol being added are 1ml:105.5g.
5. the preparation process of styptic sponge according to claim 1, characterized in that the solution concentration model of the calcium chloride solution
Enclose is 1%~20%;Preferably, the solution concentration range of the calcium chloride solution is 1%~15%.
6. the preparation process of styptic sponge according to claim 1, characterized in that the styptic sponge passes through after shear forming
UV is disinfected, and the wave-length coverage of UV light is 365nm, disinfecting time 30min in the UV disinfection.
7. the preparation process of styptic sponge according to claim 3, characterized in that the green-tea extract powder passes through as follows
Step is prepared:
1) it is mixed in the ratio of dry green tea and deionized water weight ratio 1:10,30min is continuously stirred at 80 DEG C and is uniformly mixed;
It is cooled to room temperature later, adds 300ml dehydrated alcohol, stand for 24 hours, obtain the green-tea extract for being mixed with green tea residue
Solution;Removal green tea residue is refiltered, green-tea extract solution is obtained;
2) for 24 hours in -80 DEG C of freezing green-tea extract solution, then freeze drier is placed in -45 DEG C of freeze-drying 48h, obtain green
Tea extraction solid, then crush to obtain green-tea extract powder.
8. a kind of styptic sponge, which is characterized in that including chitosan-carboxymethyl chitosan complex matrix and be attached to described compound
Green-tea extract on matrix is made of the preparation process of any one of claim 1~7 styptic sponge.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1670061A (en) * | 2005-03-21 | 2005-09-21 | 上海美宝生命科技有限公司 | Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof |
CN101755953A (en) * | 2008-10-16 | 2010-06-30 | 曹翠珍 | Green tea extract with blood sugar reducing effect and preparation method thereof |
CN106943621A (en) * | 2017-04-21 | 2017-07-14 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin albumen composite biological tissues repair materials and preparation method thereof |
CN108653478A (en) * | 2017-09-06 | 2018-10-16 | 四川云想科技有限公司 | A kind of antibacterial anti-inflammatory externally-used embrocation and its preparation method and application |
-
2018
- 2018-12-05 CN CN201811478635.7A patent/CN109331217A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1670061A (en) * | 2005-03-21 | 2005-09-21 | 上海美宝生命科技有限公司 | Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof |
CN101755953A (en) * | 2008-10-16 | 2010-06-30 | 曹翠珍 | Green tea extract with blood sugar reducing effect and preparation method thereof |
CN106943621A (en) * | 2017-04-21 | 2017-07-14 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin albumen composite biological tissues repair materials and preparation method thereof |
CN108653478A (en) * | 2017-09-06 | 2018-10-16 | 四川云想科技有限公司 | A kind of antibacterial anti-inflammatory externally-used embrocation and its preparation method and application |
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