CN109331166A - 一种用于治疗胃病的中药组合物及其制备方法 - Google Patents
一种用于治疗胃病的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种用于治疗胃病的中药组合物及其制备方法。该中药组合物包括按重量份数计的以下组分:党参10~30份,黄芪15~45份,白术5~20份,白芍5~20份,白芨5~15份,三七1~10份,枳实5~15份,砂仁5~15份,没药5~20份,九香虫5~20份,莱菔子15~45份,干姜5~20份,桂枝5~20份,小茴香5~15份,广木香5~15份,厚朴5~20份,甘草5~15份。上述组分具有补虚益气、提举清阳的作用,使胃病自强自愈并进行自我修复。
Description
技术领域
本发明涉及中医药技术领域,具体涉及一种用于治疗胃病的中药组合物,以及该中药组合物的制备方法。
背景技术
胃病是许多与胃相关疾病的统称。它们有相似的症状,如上腹胃脘部不适、疼痛、饭后饱胀、嗳气、返酸,甚至恶心、呕吐等。临床上常见的胃病有急性胃炎、慢性胃炎、胃溃疡、十二指肠溃疡、胃十二指肠复合溃疡、胃息肉、胃结石、胃的良恶性肿瘤,还有胃黏膜脱垂症、急性胃扩张、幽门梗阻等。
在现代社会中,越来越多的人患有胃部疾病。患病原因是由于一日三餐缺乏规律性,或者是因为寒冷天气没有做到足够的保暖而导致胃部收到刺激,还有的是因为长期食用辛辣、刺激的食物使得胃粘膜受损。
现在市面上常见的胃药以西药为主,在使用初期有治疗效果,但对胃病无法根治。若长期使用西药,还具有一定程度的副作用,比如会导致血压升高、便秘或腹泻等症状。因此胃病患者需要长期忍受疼痛的困扰,给生活带来极大不便。且胃病患者具有治疗后复发率高、久治不愈的特点,因此一旦患有胃病,导致患者痛苦不堪。
鉴于此,特提出本发明。
发明内容
本发明的第一目的在于提供一种用于治疗胃病的中药组合物。
本发明的第二目的在于提供上述中药组合物的制备方法。
为实现上述目的,本发明的技术方案如下:
本发明涉及一种用于治疗胃病的中药组合物,包括按重量份数计的以下组分:党参10~30份,黄芪15~45份,白术5~20份,白芍5~20份,白芨5~15份,三七1~10份,枳实5~15份,砂仁5~15份,没药5~20份,九香虫5~20份,莱菔子15~45份,干姜5~20份,桂枝5~20份,小茴香5~15份,广木香5~15份,厚朴5~20份,甘草5~15份。
优选地,所述中药组合物还含有按重量份数计的以下组分:黄药子15~45份,藤梨根40~70份,露蜂房10~40份,穿山甲5~15份,瓦楞子15~45份,鳖甲5~15份,朴硝5~15份。
优选地,所述中药组合物还含有按重量份数计的以下组分:佛手5~20份,鸡内金15~45份,乌贼骨15~45份。
优选地,所述中药组合物包括按重量份数计的以下组分:党参15份,黄芪30份,白术15份,白芍15份,白芨10份,三七6份,枳实10份,砂仁10份,佛手15份,没药15份,九香虫15份,佛手15份,莱菔子30份,黄药子30份,瓦楞子30份,藤梨根60份,鸡内金30份,乌贼骨30份,露蜂房20份,穿山甲10份,鳖甲10份,干姜15份,桂枝15份,小茴香10份,广木香10份,厚朴15份,朴硝10份,甘草10份。
本发明还涉及所述中药组合物的制备方法,包括将上述组分混合后制丸或制膏。
优选地,所述制备方法包括:将上述组分粉碎后采用蜂蜜调和,制成重量为0.2~1g的丸剂。
优选地,将上述组分粉碎成粒径≤200目的颗粒。
优选地,所述蜂蜜为油菜花蜜。
优选地,所述制备方法包括:将上述组分水煎后,取药汁浓缩成膏。
优选地,所述水煎步骤包括:向药物组分中加入3~5倍重量的水,浸泡药物2~3小时,然后水煎60~120分钟。
本发明的有益效果:
本发明提供的中药组合物能提升人体的代谢能力,其中党参、黄芪、白术有和中补气的作用;砂仁、白芍、厚朴、广木香有芳香悦胃的作用;干姜、桂枝、小茴香有温中补气的作用;白芨、三七、枳实、没药、九香虫有止血、止痛的作用。在本发明优选的方案中,以佛手、莱菔子除胀去满,使之畅气;以佛手、鸡内金、乌贼骨消积、健胃、平衡酸咸度,使之顺气;以黄药子、藤梨根、露蜂房、穿山甲、瓦楞子、鳖甲、朴硝软坚、散结、化邪,令其正气;后以甘草调和诸药,对治疗胃病具有良好的效果。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
本发明实施例涉及一种用于治疗胃病的中药组合物,包括按重量份数计的以下组分:党参10~30份,黄芪15~45份,白术5~20份,白芍5~20份,白芨5~15份,三七1~10份,枳实5~15份,砂仁5~15份,没药5~20份,九香虫5~20份,莱菔子15~45份,干姜5~20份,桂枝5~20份,小茴香5~15份,广木香5~15份,厚朴5~20份,甘草5~15份。
本发明中药制剂的各成分之间具有协同作用,对于各类胃部疾病具有明显的治疗效果,无毒副作用。具体各成分的疗效如下:
党参,为桔梗科植物党参、素花党参、或川党参等的干燥根。党参味甘,性平。用于脾肺气虚、食少倦怠、咳嗽虚喘、气血不足、面色萎黄、心悸气短、津伤口渴、内热消渴。具有补中益气、和脾胃、除烦渴的功效。
黄芪,为豆科植物蒙古黄芪的根。性温,味甘。功能主治为:补气固表、托毒排脓、利尿、生肌。用于气虚乏力、久泻脱肛、自汗、水肿、子官脱垂、慢性肾炎蛋白尿、糖尿病、疮口久不愈合。
白术,属于菊科、苍术属多年生草本植物,以根茎入药。味苦,甘,性温。归脾、胃经。白术具有健脾益气、燥湿利水、止汗、安胎的功效,用于脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安。
白芍,为毛茛科植物芍药Paeonia tacti lora Pall.的干燥根。味苦、酸,性微寒。归肝、脾经。具有养血调经、敛阴止汗、柔肝止痛、平抑肝阳之功效。常用于血虚萎黄、月经不调、自汗、盗汗、胁痛、腹痛、四肢挛痛、头痛眩晕。
白芨,又名白及,为兰科植物白及Bletilla striata(Thunb.)Reichb.f.的干燥块茎。苦、甘、涩,微寒。归肺、肝、胃经。具有收敛止血、消肿生肌的功效。用于咯血、吐血、外伤出血、疮疡肿毒、皮肤皲裂。
三七,为五加科植物三七Panax notoginseng(Burk.)F.H.Chen的干燥根和根茎。味甘、微苦,温。归肝、胃经。具有散瘀止血、消肿定痛的功效。用于咯血、吐血、衄血、便血、崩漏、外伤出血、胸腹刺痛、跌扑肿痛。
枳实,为芸香科植物酸橙Citrus aurantium L.及其栽培变种或甜橙Citrussinensis Osbeck的干燥幼果。味苦、辛、酸,微寒。归脾、胃经。具有破气消积、化痰散痞的功效。用于积滞内停、痞满胀痛、泻痢后重、大便不通、痰滞气阻、胸痹、结胸、脏器下垂。
砂仁,为姜科植物阳春砂Amomum villosum Lour.、绿壳砂Amomum villosumLour.var.xanthioides T.L.Wu et Senjen或海南砂Amomum longiligulare T.L.Wu的干燥成熟果实。味辛,性温。归脾、胃、肾经。有化湿开胃、温脾止泻、理气安胎的功效。用于湿浊中阻、脘痞不饥、脾胃虚寒、呕吐泄泻、妊娠恶阻、胎动不安。
没药,为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphoramolmol Engl.的干燥树脂。分为天然没药和胶质没药。分布于索马里、埃塞俄比亚及阿拉伯半岛南部等地。味辛、苦,性平。归心、肝、脾经。具有散瘀定痛、消肿生肌之功效。常用于胸痹心痛、胃脘疼痛、痛经经闭、产后瘀阻、癥瘕腹痛、风湿痹痛、跌打损伤、痈肿疮疡等病症的治疗。
九香虫,为兜蝽科九香虫属下的一个种。味咸,温。归肝、脾、肾经。具有理气止痛、温中助阳的功效。用于胃寒胀痛、肝胃气痛、肾虚阳痿、腰膝酸痛。
莱菔子,为十字花科植物萝卜Raphanus sativus L.的干燥成熟种子。味辛、甘,平。归肺、脾、胃经。具有消食除胀、降气化痰的功效。用于饮食停滞、脘腹胀痛、大便秘结、积滞泻痢、痰壅喘咳。
干姜,中药名。为姜科植物姜Zingiber oj-jicinale Rosc.的干燥根茎。味辛,性热。归脾、胃、肾、心、肺经。具有温中散寒、回阳通脉、温肺化饮的功效。用于脘腹冷痛、呕吐泄泻、肢冷脉微、寒饮喘咳。
桂枝,属樟目,为樟科中等大乔木的嫩枝。味辛、甘,温。归心、肺、膀胱经。具有发汗解肌、温通经脉、助阳化气、平冲降气的功效。常用于风寒感冒、脘腹冷痛、血寒经闭、关节痹痛、痰饮、水肿、心悸等。
小茴香,中药名。为伞形科植物茴香Foeniculum vuLgare Mill.的干燥成熟果实。味辛,性温。归肝、肾、脾、胃经。有散寒止痛、理气和胃的功效。用于寒疝腹痛、睾丸偏坠、痛经、少腹冷痛、脘腹胀痛、食少吐泻。
广木香,为菊科植物木香Aucklandia lappa Decne.的干燥根。因古时从广东进口,称为广木香。味辛、苦,温。归脾、胃、大肠、三焦、胆经。具有行气止痛、健脾消食的功效。用于胸胁、脘腹胀痛、泻痢后重、食积不消、不思饮食。
厚朴,为木兰科植物厚朴Magnolia officinalis Rehd.et Wils.或凹叶厚朴Magnolia offinalis Rehd.et Wils.var.biloba Rehd.et Wils.的干燥干皮、根皮及枝皮。味苦、辛,性温。归脾、胃、肺、大肠经。具有燥湿消痰、下气除满的功效。用于湿滞伤中、脘痞吐泻、食积气滞、腹胀便秘、痰饮喘咳。
甘草,为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhizainflata Bat.或光果甘草Glycyrrhiza glabraL.的干燥根和根茎。味甘,性平。归心、肺、脾、胃经。具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药之功效。常用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
在本发明的一个实施例中,该中药组合物还含有按重量份数计的以下组分:黄药子15~45份,藤梨根40~70份,露蜂房10~40份,穿山甲5~15份,瓦楞子15~45份,鳖甲5~15份,朴硝5~15份。
其中,黄药子为薯蓣科薯蓣属植物黄独Dioscorea bulbifera L.的干燥块茎。味苦、辛,性凉。归肝、胃、心、肺经。具有解毒消肿,化痰散结,凉血止血之功效。常用于甲状腺肿大,淋巴结结核,咽喉肿痛,吐血,咯血,百日咳,癌肿;外用治疮疖。
藤梨根,为猕猴桃科植物猕猴桃植物的根。藤梨根主治清热解毒,清热利湿,防肿瘤抗癌,祛风除湿,利尿止血,解毒消肿,消化不良、呕吐、风湿痹痛、风湿骨痛、消化道癌肿、消化道肿瘤、痈疡疮疖、风湿骨痛及黄疸等症。
露蜂房,为胡蜂科昆虫黄星长脚黄蜂或多种近缘昆虫的巢。味甘,性平。归肝、胃、肾经。有祛风,攻毒,杀虫,止痛,抗过敏的功效。主要用于祛风镇痛,功毒散结,杀虫止痒。
穿山甲,为动物穿山甲的鳞片,主治血瘀经闭、癥瘕、风湿痹痛、乳汁不下、痈肿、瘰疬。
瓦楞子,为蚶科动物毛蚶Arca subcrenata Lischke、泥蚶Arca granosaLinnaeus或魁蚶Arca inflata Reeve的贝壳。味咸,性平。归肺、胃、肝经。具有消痰化瘀,软坚散结,制酸止痛的功效。用于顽痰胶结,黏稠难咯,瘿瘤,瘰疬,症瘕痞块,胃痛泛酸。
鳖甲,为鳖科动物鳖Trionyx sinensis Wiegmann的背甲。味咸,性微寒。归肝、肾经。具有滋阴潜阳、退热除蒸、软坚散结之功效。常用于阴虚发热、骨蒸劳热、阴虚阳亢、头晕目眩、虚风内动、经闭、癥瘕、久疟疟母。
朴硝是芒硝的粗制品,经加工精制而成的结晶体为芒硝。经脱水者称为玄明粉。朴硝,芒硝,玄明粉功效相同。主要成分为硫酸钠,常夹杂微量硫酸镁,氯化钠,硫酸钙等。玄明粉则系纯粹的硫酸钠。味咸,苦,性寒。归肺、胃、大肠经。具有通便导滞、泻火解毒的功效。
在本发明的一个实施例中,该中药组合物还含有按重量份数计的以下组分:佛手5~20份,鸡内金15~45份,乌贼骨15~45份。
其中,佛手为芸香科植物佛手CitrusmedicaLvar.sarcodac-tylisSwingle的干燥果实。味辛、苦、酸,性温。归肝、脾、胃、肺经。有疏肝理气,和胄止痛,燥湿化痰的功效。用于肝胃气滞,胸胁胀痛,胃脘痞满,食少呕吐,咳嗽痰多。
鸡内金,为雉科动物家鸡Gallusgallusdomesticus Brisson的干燥沙囊内壁。味甘,平。归脾、胃、小肠、膀胱经。具有健胃消食,涩精止遗,通淋化石的功效。用于食积不消,呕吐泻痢,小儿疳积,遗尿,遗精,石淋涩痛,胆胀胁痛。
乌贼骨是乌鲗科动物无针乌鲗或金乌鲗的内壳。中医用做止血药。味咸、涩,温。归脾、肾经。具有制酸止痛、止血、接骨、骨缺损修复、抗辐射、抗肿瘤、抗溃疡等作用。
在本发明的一个最优选实施例中,该中药组合物包括按重量份数计的以下组分:党参15份,黄芪30份,白术15份,白芍15份,白芨10份,三七6份,枳实10份,砂仁10份,佛手15份,没药15份,九香虫15份,佛手15份,莱菔子30份,黄药子30份,瓦楞子30份,藤梨根60份,鸡内金30份,乌贼骨30份,露蜂房20份,穿山甲10份,鳖甲10份,干姜15份,桂枝15份,小茴香10份,广木香10份,厚朴15份,朴硝10份,甘草10份。
本发明还涉及该中药组合物的制备方法,包括将上述组分混合后制丸或制膏。
在本发明的一个实施例中,丸剂的制备方法包括:将上述各组分清除杂质与异物后进行粉碎,然后采用蜂蜜调和,制成重量为0.2~1g的丸剂。其中,优选将上述组分粉碎成粒径≤200目的颗粒。所用蜂蜜为油菜花蜜。
在本发明的一个实施例中,膏剂的制备方法包括:将上述组分水煎后,取药汁浓缩成膏。
进一步地,膏剂的制备方法包括:将上述各组分清除杂质与异物后,向药物组分中加入3~5倍重量的水,浸泡药物2~3小时。然后将水与药物的混合物转入瓦锅,先用武火煎沸5分钟,再以文火煎煮90~100分钟,然后将药液过滤。取上述滤液置于蒸发锅中,先以武火加热至沸,药液变浓时改用文火,保持微沸,不断搅拌防止焦化。当药液浓缩至稠膏状时沾取少许滴于滤纸上检视,以无渗润水迹为度。此时好的稠膏,传统上习称为“清膏”,传统的经验是采用滴于桑皮纸上检验无渗润水迹为度,或用棒挑起呈片状落下为度,现在多采用比重计测定比重作为判断浓缩的程度。
丸剂的服用方法为:成人每天3次,每次9-12g。餐后90-120分钟内采用温开水送服,服药后60-90分钟不可进食。儿童用量减半。
膏剂的服用方法为:成人每天3次,每次120-150ml。餐后90-120分钟内采用温开水送服,服药后60-90分钟不可进食。儿童用量减半。
服药的注意事项为:1、服药不能间断。2、禁食白糖、葱、姜、蒜等辛辣食物,以及地瓜、土豆、柿子、茄子、板栗等滞气食品。
申请人对本发明中药组合物的病理药理解析如下:
古人云:胃气一败,凡病皆来。由此可知,胃病的成因主要为中气虚耗,升举无力,导致凡病皆来。表现为或寒或热,或返酸、或返咸,或发炎、或发烧,或返流、或溃疡等。治疗的关键是擒贼先擒王,抓住主要病因,一治到位,兼收其余。即补虚益气,提举清阳,让胃得到足够多的原动力,使其自强自愈并进行自我修复。临床证明,诸多胃病确实治而不愈,不治反而自愈。其中原因,特此揭晓。
本发明提供的中药组合物能提升人体的代谢能力,其中党参、黄芪、白术有和中补气的作用;砂仁、白芍、厚朴、广木香有芳香悦胃的作用;干姜、桂枝、小茴香有温中补气的作用;白芨、三七、枳实、没药、九香虫有止血、止痛的作用。在本发明优选的方案中,以佛手、莱菔子除胀去满,使之畅气;以佛手、鸡内金、乌贼骨消积、健胃、平衡酸咸度,使之顺气;以黄药子、藤梨根、露蜂房、穿山甲、瓦楞子、鳖甲、朴硝软坚、散结、化邪,令其正气;后以甘草调和诸药,对治疗胃病具有良好的效果。
实施例1
取党参15克,黄芪30克,白术15克,白芍15克,白芨10克,三七6克,枳实10克,砂仁10克,佛手15克,没药15克,九香虫15克,佛手15克,莱菔子30克,黄药子30克,瓦楞子30克,藤梨根60克,鸡内金30克,乌贼骨30克,露蜂房20克,穿山甲10克,鳖甲10克,干姜15克,桂枝15克,小茴香10克,广木香10克,厚朴15克,朴硝10克,甘草10克。将上述药物组分粉碎至200目以下,用油菜花蜜调和制成0.2g/丸的丸剂,装瓶制成。
实施例2
取党参15克,黄芪30克,白术15克,白芍15克,白芨10克,三七6克,枳实10克,砂仁10克,佛手15克,没药15克,九香虫15克,佛手15克,莱菔子30克,鸡内金30克,乌贼骨30克,露蜂房20克,穿山甲10克,干姜15克,桂枝15克,小茴香10克,广木香10克,厚朴15克,甘草10克。制备方法与实施例1相同。
实施例3
取党参15克,黄芪30克,白术15克,白芍15克,白芨10克,三七6克,枳实10克,砂仁10克,没药15克,九香虫15克,佛手15克,莱菔子30克,黄药子30克,瓦楞子30克,藤梨根60克,露蜂房20克,穿山甲10克,鳖甲10克,干姜15克,桂枝15克,小茴香10克,广木香10克,厚朴15克,朴硝10克,甘草10克。
临床结果
在2008-2018年之间,申请人使用实施例1的中药组合物,接诊治疗胃病患者1021人,其中有效1016人,有效者标准以现代医疗检查结果为凭。有效者中显效908人,显效标准以现代医疗检查结果为凭。显效者中临床治愈763人,临床治愈标准以现代医疗检查结果为凭。由此可得,该中药组合物的有效率高于80%,显效率高于68%,治愈率高于62%。
对于实施例2的中药组合物,其有效率高于75%,显效率高于63%,治愈率高于58%。
对于实施例3的中药组合物,其有效率高于70%,显效率高于59%,治愈率高于55%。
典型病例
1、李某,男,45岁,症状为厌食、消瘦,常年胃胀。服用本发明制得的中药组合物,服用7天后症状缓解,两个月后治愈。
2、林某,男,10岁,发育不良,腹胀如鼓,常年手脚冰凉。服用本发明制得的中药组合物后,服用10天后症状减轻,1个月后治愈。
3、张某,女,42岁,常年胃疼、反酸、易呕吐,服用15天后症状减轻,3个月后治愈。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种用于治疗胃病的中药组合物,其特征在于,包括按重量份数计的以下组分:党参10~30份,黄芪15~45份,白术5~20份,白芍5~20份,白芨5~15份,三七1~10份,枳实5~15份,砂仁5~15份,没药5~20份,九香虫5~20份,莱菔子15~45份,干姜5~20份,桂枝5~20份,小茴香5~15份,广木香5~15份,厚朴5~20份,甘草5~15份。
2.根据权利要求1所述的中药组合物,其特征在于,所述中药组合物还含有按重量份数计的以下组分:黄药子15~45份,藤梨根40~70份,露蜂房10~40份,穿山甲5~15份,瓦楞子15~45份,鳖甲5~15份,朴硝5~15份。
3.根据权利要求2所述的中药组合物,其特征在于,所述中药组合物还含有按重量份数计的以下组分:佛手5~20份,鸡内金15~45份,乌贼骨15~45份。
4.根据权利要求1至3任一项所述的中药组合物,其特征在于,所述中药组合物包括按重量份数计的以下组分:党参15份,黄芪30份,白术15份,白芍15份,白芨10份,三七6份,枳实10份,砂仁10份,佛手15份,没药15份,九香虫15份,佛手15份,莱菔子30份,黄药子30份,瓦楞子30份,藤梨根60份,鸡内金30份,乌贼骨30份,露蜂房20份,穿山甲10份,鳖甲10份,干姜15份,桂枝15份,小茴香10份,广木香10份,厚朴15份,朴硝10份,甘草10份。
5.根据权利要求1至4任一项所述的中药组合物的制备方法,其特征在于,包括将上述组分混合后制丸或制膏。
6.根据权利要求5所述的方法,其特征在于,所述制备方法包括:将上述组分粉碎后采用蜂蜜调和,制成重量为0.2~1g的丸剂。
7.根据权利要求6所述的方法,其特征在于,将上述组分粉碎成粒径≤200目的颗粒。
8.根据权利要求6所述的方法,其特征在于,所述蜂蜜为油菜花蜜。
9.根据权利要求5所述的方法,其特征在于,所述制备方法包括:将上述组分水煎后,取药汁浓缩成膏。
10.根据权利要求9所述的方法,其特征在于,所述水煎步骤包括:向药物组分中加入3~5倍重量的水,浸泡药物2~3小时,然后水煎60~120分钟。
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