CN109328111B

CN109328111B - Reagent tube

Info

Publication number: CN109328111B
Application number: CN201680082740.1A
Authority: CN
Inventors: 李雪琳; 曹利民
Original assignee: Biologix Plastics Co ltd; Jinan Biologix Biological Engineering Co ltd; Biologix Group Ltd
Current assignee: Biologix Plastics Co ltd; Jinan Biologix Biological Engineering Co ltd; Biologix Group Ltd
Priority date: 2016-06-23
Filing date: 2016-06-23
Publication date: 2021-07-09
Anticipated expiration: 2036-06-23
Also published as: WO2017219323A1; CN109328111A

Abstract

A reagent tube, comprising: a pipe body (1) with two open ends, an upper cover body (2), a lower cover body (3), a sealing piece (4) and a removable annular component (5); the pipe body (1) comprises an outer pipe (101) and an inner pipe (102), the outer pipe (101) comprises an upper connecting section (1011), a middle supporting section (1012) and a lower connecting section (1013) which are sequentially communicated, and the inner pipe (102) is arranged in the middle supporting section (1012); the two sealing pieces (4) are respectively arranged at the cover openings of the upper cover body (2) and the lower cover body (3) to form a closed accommodating cavity in the upper cover body (2) and the lower cover body (3); two removable annular components (5) are respectively arranged at the top of the upper connecting section (1011) and the bottom of the lower connecting section (1013); internal threads (103) are arranged on the inner walls of the upper connecting section (1011) and the lower connecting section (1013), external threads (201) matched with the internal threads (103) are arranged on the outer walls of the lower end of the upper cover body (2) and the upper end of the lower cover body (3), and the upper cover body (2) and the upper connecting section (1011) as well as the lower cover body (3) and the lower connecting section (1013) are in threaded connection.

Description

Reagent tube

Technical Field

The invention relates to the technical field of biology, in particular to a reagent tube.

Background

Biological reagents are mostly biological materials or organic compounds used for life science research and reagents used for clinical diagnosis and medical research, and have high requirements on purity. Before use, most biological reagents are subjected to storage, transfer or pretreatment and the like, and the biological reagents are easy to deteriorate in the processes, so that the purity of the biological reagents is reduced. Therefore, in order to prevent the purity of the biological reagent from being lowered in the above-mentioned process, it is necessary to provide a reagent container which is excellent in sealing property and storability and is easy to handle.

In the prior art, a sterilized flip type reagent tube and a screw-type reagent tube are generally used as a reagent container, wherein the flip type reagent tube comprises a tube body and an open-close type cover body arranged at the top of the tube body, and the flip type reagent tube is opened or closed by turning up or turning down the cover body. The screw-type reagent tube comprises a tube body and a cover body in threaded connection with the tube body, and the screw-type reagent tube is opened or closed by screwing the cover body clockwise or anticlockwise.

The inventor finds that the prior art has at least the following problems:

when the biological reagent comprises two components, such as a lyophilized powder component and a solvent component, and is required to be dispensed immediately, each component must be stored separately in a separate reagent tube during storage, and each component must be thoroughly mixed in the same reagent tube or other container during use, which requires secondary transfer of at least one of the components. The reagent tube provided by the prior art is used for storing the reagent, each component needs to be separately arranged in an independent reagent tube and mixed when in use, so that the cost of manpower and material resources is increased, the mixing process is ensured to be carried out under the aseptic condition, and otherwise, the reagent is extremely easy to be polluted due to the contact with the external environment.

Disclosure of Invention

The technical problem to be solved by the embodiment of the invention is to provide a reagent tube which is suitable for a biological reagent comprising two components and is required to be ready to use, is convenient to operate and good in sealing performance, and avoids the reagent components from contacting an external environment in the mixing process. The specific technical scheme is as follows:

a reagent tube, the reagent tube comprising: the device comprises a pipe body with openings at two ends, an upper cover body, a lower cover body, a sealing piece and a removable annular part;

the pipe body comprises an outer pipe and an inner pipe, the outer pipe comprises an upper connecting section, a middle supporting section and a lower connecting section which are sequentially communicated, and the inner pipe is arranged in the middle supporting section;

the two sealing pieces are respectively arranged at the cover openings of the upper cover body and the lower cover body so as to form a closed accommodating cavity in the upper cover body and the lower cover body;

two removable ring-shaped parts are respectively arranged at the top of the upper connecting section and the bottom of the lower connecting section;

the upper connecting section and the lower connecting section are provided with internal threads on the inner wall, the lower end of the upper cover body and the outer wall of the upper end of the lower cover body are provided with external threads matched with the internal threads, the upper cover body and the upper connecting section and the lower cover body are in threaded connection with the lower connecting section, when the removable annular component is removed, the upper cover body and the lower cover body can further perform spiral motion, and the pipe orifice of the inner pipe applies pressure to the two sealing pieces to enable the sealing pieces to break.

Preferably, the reagent tube further comprises: and the two blocking parts are respectively arranged on the outer walls of the upper cover body and the lower cover body and are used for being in contact with the removable annular component in an abutting mode.

Specifically, the stopper is an annular flange that protrudes outward in the radial direction of the upper cover and the lower cover.

Specifically, the inner tube includes last puncture section, well linkage segment and the lower puncture section that communicates in order, well linkage segment with well support the section and pass through the connecting piece fixed together, go up the puncture section with go up the linkage segment and puncture section down with be provided with the clearance down between the linkage segment, the clearance is used for holding go up the lid with the wall of the flap mouth of lid down.

Specifically, as preferred, the outer tube with the inner tube sets up with one heart, go up the puncture section with puncture section down is the body that the external diameter is unchangeable and the internal diameter is changeable, just the internal diameter of going up the puncture section is from top to bottom crescent, the internal diameter of puncture section is crescent from top to bottom down.

Preferably, the outer diameter of the upper puncture section is equal to the inner diameter of the upper cover body, and the outer diameter of the lower puncture section is equal to the inner diameter of the lower cover body.

Optionally, the outer walls of the upper and lower piercing sections are provided with a layer of elastic coating.

Optionally, the outer wall of the end part of the upper puncture section and the lower puncture section close to the middle connection section is sleeved with a sealing ring.

Particularly, as a preference, an anti-slip structure is arranged on the outer wall of the outer pipe.

Specifically, the tube body, the upper cover body and the lower cover body are all made of medical-grade polymers;

the sealing piece is made of medical-grade metal foil.

The technical scheme provided by the embodiment of the invention has the following beneficial effects:

when the reagent tube provided by the embodiment of the invention is used for containing a two-component biological reagent, the two components can be respectively and hermetically placed in the upper cover body and the lower cover body and are in threaded connection with the tube body part to form an independent reagent tube. When the biological reagent is used, the removable annular component is removed, the upper cover body and the lower cover body are further rotated to move towards the direction of the nozzle of the inner tube until the nozzle of the inner tube applies pressure to the two sealing pieces to break the sealing pieces, and at the moment, the components in the upper cover body and the lower cover body are fully mixed to realize ready use. Therefore, the reagent tube provided by the embodiment of the invention can simultaneously bear two components such as freeze-dried powder and solvent, and can be mixed without opening the reagent tube when in use, so that the cost of manpower and material resources is reduced, the operation convenience is improved, the sealing property of the reagent tube is ensured, the secondary pollution caused by the fact that the reagent contacts with an external environment when being mixed is avoided, and the reagent tube is safer and more reliable.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1-1 is a front view of a reagent vessel provided in an embodiment of the present invention;

FIGS. 1-2 are cross-sectional views of a reagent vessel provided in accordance with yet another embodiment of the present invention;

FIG. 2-1 is a front view of a tube body of a reagent tube according to yet another embodiment of the present invention;

FIG. 2-2 is a cross-sectional view of a tube body of a reagent tube according to yet another embodiment of the present invention;

FIG. 3-1 is a front view of an upper cover of a reagent vessel according to yet another embodiment of the present invention;

FIG. 3-2 is a sectional view of an upper cover of a reagent vessel according to still another embodiment of the present invention.

The reference numerals denote:

1, a pipe body is arranged in a pipe body,

101 an outer tube, and a sealing ring,

the upper end of the upper end 1011 is connected with a segment,

1012, the support section is arranged on the upper portion of the support section,

1013 a lower connecting section, wherein the lower connecting section,

102 of the inner tube,

1021, a puncture section is arranged on the needle,

1022 of the connection section of the first and second bodies,

1023 the lower piercing section and the lower piercing section,

103 of the internal screw thread, and,

2, an upper cover body is arranged on the upper cover body,

201 an external thread,

3 a lower cover body is arranged on the lower cover body,

4, a sealing piece is arranged on the upper surface of the container,

5 a ring-shaped member having a ring-shaped cross section,

6 a barrier member is provided to prevent the flow of gas,

7, a connecting piece is arranged on the lower part of the frame,

8 anti-skid structure.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

An embodiment of the present invention provides a reagent tube, as shown in fig. 1-1 and fig. 1-2, the reagent tube including: a tube body 1 with two open ends, an upper cover 2, a lower cover 3, a sealing member 4, and a removable ring member 5. Wherein, body 1 includes outer tube 101 and inner tube 102, and outer tube 101 includes upper linkage 1011, well support section 1012 and lower linkage 1013 that communicate in proper order, and inner tube 102 sets up in well support section 1012. Two sealing members 4 are respectively disposed at the pipe orifices of the upper cover body 2 and the lower cover body 3 to form a closed accommodating chamber in the upper cover body 2 and the lower cover body 3. Two removable ring members 5 are provided at the top of the upper connecting section 1011 and at the bottom of the lower connecting section 1013, respectively.

As further shown in fig. 2-1 and 2-2, the inner walls of the upper connecting section 1011 and the lower connecting section 1013 of the outer tube 101 are provided with internal threads 103, the outer walls of the lower end of the upper cover 2 and the upper end of the lower cover 3 are provided with external threads 201 matching with the internal threads 103, and for example, the structure of the external threads 201 on the upper cover 2 can be seen in fig. 3-1 and 3-2. The upper cap 2 and the upper connecting section 1011 and the lower cap 3 and the lower connecting section 1013 are screwed together, and when the removable ring-shaped member 5 is removed, the upper cap 2 and the lower cap 3 can be further screwed, and the opening of the inner tube 102 applies pressure to the two sealing members 4 to break the sealing members 4.

When the reagent tube provided by the embodiment of the invention is used for containing a two-component biological reagent, the two components can be respectively and hermetically placed in the upper cover body 2 and the lower cover body 3 and are in threaded connection with the tube body 1 to form an independent reagent tube. When the biological reagent is used, the removable annular component 5 is removed, and the upper cover body 2 and the lower cover body 3 are further rotated to move towards the direction of the nozzle of the inner tube 102 until the nozzle of the inner tube 102 applies pressure to the two sealing members 4 to break the sealing members 4, and then the components in the upper cover body 2 and the lower cover body 3 are fully mixed to realize ready use. Therefore, the reagent tube provided by the embodiment of the invention can simultaneously bear two components such as freeze-dried powder and solvent, and can be mixed without opening the reagent tube when in use, so that the cost of manpower and material resources is reduced, the operation convenience is improved, the sealing property of the reagent tube is ensured, the secondary pollution caused by the fact that the reagent contacts with an external environment when being mixed is avoided, and the reagent tube is safer and more reliable.

In addition, as will be understood by those skilled in the art, for a biological reagent that includes two components, such as a lyophilized powder component and a solvent component, and is required to be ready to use when being prepared, the lyophilized powder and the solvent of the same batch are generally required to be mixed for use, so as to ensure that the coefficient of variation of the lyophilized powder and the solvent are consistent and maintained at a low level, thereby achieving the desired quality of the reagent. The reagent tube provided by the embodiment of the invention can effectively solve the problems, ensure the quality of the reagent, avoid marking the components of the same batch in the split charging process and realize high-precision and high-efficiency split charging in a factory. Of course, the reagent tube provided by the embodiment of the invention can be used for storing and mixing biological reagents, and can also be used for containing other products such as drinks, health care products and the like which are ready to be prepared and used when the size of the reagent tube is changed.

In the first aspect, the two removable ring-shaped members 5 are respectively disposed at the top of the upper connecting section 1011 and the bottom of the lower connecting section 1013, so that when the ring-shaped members 5 exist, the upper cover 2 and the upper connecting section 1011 and the lower cover 3 and the lower connecting section 1013 are only partially screwed, i.e. a complete fit cannot be achieved; when the ring-shaped member 5 is removed, the upper cap 2 and the lower cap 3 can be further rotated to move toward the opening of the inner tube 102 until the upper cap 2 and the upper connecting section 1011 and the lower cap 3 and the lower connecting section 1013 are completely screwed, and the openings of the upper and lower ends of the inner tube 102 can apply pressure to the sealing members 4 of the upper cap 2 and the lower cap 3 to break them (which also determines the width of the ring-shaped member 5). In a second aspect, the upper cover 2 and the lower cover 3 are used as containers for holding reagents, the internal volumes of the upper cover 2 and the lower cover 3 are adjusted according to the amount of reagents to be held, and the internal volumes of the upper cover 2 and the lower cover 3 may be the same or different, which is not limited in this embodiment of the present invention. In a third aspect, the embodiment of the present invention seals the opening of the upper cap 2 and the lower cap 3 by using the sealing member 4, so that they form a container having a sealed accommodating chamber. The sealing member 4 is preferably configured to conform to the openings of the upper lid member 2 and the lower lid member 3, and after the reagent is filled in the upper lid member 2 and the lower lid member 3, the sealing member 4 is fixed to the openings by heat press fusion, adhesion, or the like.

Preferably, as shown in fig. 3-1 and 3-2, the reagent tube provided by the embodiment of the present invention further includes two blocking members 6, and the two blocking members 6 are respectively disposed on the outer walls of the upper cover body 2 and the lower cover body 3 for abutting contact with the removable annular member 5. By providing the blocking member 6 on the outer walls of the upper cap 2 and the lower cap 3, for example at a central position thereof, the blocking member 6 can be brought into contact against the removable annular member 5 without mixing the two cap internal components, avoiding over-rotation of the upper cap 2 and the lower cap 3, which could cause the spout of the inner tube 102 to pierce the closure 4.

In particular, the stop 6 is preferably an annular flange projecting outwards in the radial direction of the upper cover 2 and of the lower cover 3, so as to be in contact against the removable annular part 5 as a whole, ensuring its stopping effect. Of course, the blocking member 6 may be a plurality of projections projecting outward in the radial direction of the upper lid body 2 and the lower lid body 3.

Specifically, in the reagent tube provided in the embodiment of the present invention, as shown in fig. 1-2, the inner tube 102 includes an upper piercing section 1021, a middle connecting section 1022 and a lower piercing section 1023 which are sequentially communicated, wherein the middle connecting section 1022 of the inner tube 102 and the middle supporting section 1012 of the outer tube 101 are fixed together by a connecting member 7, and the connecting member 7 may be a plurality of connecting rods with two ends respectively fixed on the middle connecting section 1022 of the inner tube 102 and the middle supporting section 1012 of the outer tube 101, or preferably a ring piece located therebetween. Gaps are provided between the upper piercing section 1021 of the inner tube 102 and the upper connecting section 1011 of the outer tube 101 and between the lower piercing section 1023 of the inner tube 102 and the lower connecting section 1013 of the outer tube 101, and the gaps are used for accommodating the walls of the nozzles of the upper cap 2 and the lower cap 3, so that the nozzles of the upper cap 2 and the lower cap 3 enter the gaps when the caps are further rotated, and the sealing piece 4 can be ensured to be broken by the nozzle of the inner tube 102.

Preferably, in the embodiment of the present invention, as shown in fig. 2-2, the tube body 1 is a double-cylinder structure formed by an outer tube 101 and an inner tube 102, which are vertically transparent, and preferably, the outer tube 101 and the inner tube 102 are concentrically arranged and integrally formed, so that the safety and the sealing performance of the tube body 1 can be ensured. And the upper cap body 2, the lower cap body 3 and the removable annular member 5 can be produced using separate molds in accordance with the structure of the pipe body 1. Further, the inner diameters of the upper lid body 2 and the lower lid body 3 are preferably uniform, so that the reagent tube can be easily manufactured.

Specifically, for the inner tube 102, the upper piercing section 1021 and the lower piercing section 1023 are both the tube body 1 with a constant outer diameter and a variable inner diameter, and the inner diameter of the upper piercing section 1021 is gradually increased from bottom to top and the inner diameter of the lower piercing section 1023 is gradually increased from top to bottom. By controlling the outer diameters of the upper puncturing section 1021 and the lower puncturing section 1023 to be constant, the inner wall of the upper cap body 2 and the inner wall of the lower cap body 3 can be tightly matched with the outer wall of the inner tube 102 when the upper cap body 2 and the lower cap body 3 are further rotated. The inner diameters of the upper penetrating section 1021 and the lower penetrating section 1023 are controlled to be variable, so that the wall thickness at the upper end of the upper penetrating section 1021 and the lower end of the lower penetrating section 1023 is minimized, and the sealing piece 4 is penetrated more conveniently. The wall thickness of the upper end of the upper piercing section 1021 and the lower end of the lower piercing section 1023 in the inner tube 102 is controlled according to the material of the sealing element 4, so long as the sealing element 4 can be pierced by the sealing element under a certain pressure.

It will be appreciated that, in order to ensure that the nozzle of the inner tube 102 can extend into the upper cap 2 and the lower cap 3 when they are rotated, the outer diameters of the upper piercing section 1021 and the lower piercing section 1023 should be smaller than or equal to the inner diameters of the upper cap 2 and the lower cap 3. In order to prevent the freeze-dried powder and the solvent to be mixed from entering the gap between the inner tube 102 and the outer tube 101 to cause waste, it is preferable that the outer diameter of the upper puncturing section 1021 is equal to the inner diameter of the upper cap 2, and the outer diameter of the lower puncturing section 1023 is equal to the inner diameter of the lower cap 3, that is, the upper puncturing section 1021 and the lower puncturing section 1023 can just enter the upper cap 2 and the lower cap 3 respectively, and no gap exists between the upper puncturing section 1021 and the lower puncturing section 1023.

Further, in order to improve the sealing performance of the inner tube 102 when being matched with the upper cover body 2 and the lower cover body 3, a thin elastic coating layer, for example, with a thickness of about 0.5-lmm, may be disposed on the outer walls of the upper puncturing section 1021 and the lower puncturing section 1023, or a sealing ring may be sleeved on the outer walls of the end portions of the upper puncturing section 1021 and the lower puncturing section 1023, which are close to the middle connecting section 1022, so that the inner tube 102 can be more closely matched with each other when entering the upper cover body 2 and the lower cover body 3, thereby ensuring that all the freeze-dried powder and the solvent are completely mixed together, and further ensuring the quality of the biological reagent.

Preferably, the anti-slip structure 8 is disposed on the outer wall of the outer tube 101 in the embodiment of the present invention, so as to increase the friction force between the outer tube 101 and the hand of the operator, and to make the rotation of the upper cover body 2 and the lower cover body 3 more labor-saving. The anti-slip structure 8 may be implemented, for example, by treating the outer wall of the outer tube 101 to form an anti-slip texture thereon, such as a threaded structure, a staggered linear structure, or other geometric shapes. Alternatively, the outer wall of the outer tube 101 may be coated with a high-elasticity coating, and the high-elasticity coating may be processed to have anti-slip lines or may be formed by providing a plurality of granular protrusions on the surface of the high-elasticity coating.

Specifically, in the present embodiment, the removable ring-shaped member 5 is common in the art, and for example, it may be a tear-off pull ring, and the pull ring may be fixed to the upper edge of the upper connecting section 1011 and the lower edge of the lower connecting section 1013 of the outer tube 101 by a plurality of connecting columns, and the pull ring further has an opening, and a pull ring buckle is provided at one side of the opening. Or in the embodiment of the invention the removable ring-shaped part 5 is a snap ring with an opening on one side.

Since the object to be treated is a biological reagent, the reagent tube provided by the embodiment of the present invention should be strictly sterilized, and the preparation process of the reagent tube should be performed under aseptic conditions to ensure that the inside of the reagent tube is in an aseptic environment. Specifically, the material of body 1, last lid 2, lower lid 3, the cyclic annular part 5 that can remove is medical grade polymer, for example for medical grade polypropylene, polyethylene, ya keli copolymer, cyclic olefin copolymer, transparent polyamide etc. this kind of material stable performance is difficult for receiving external environment to influence and takes place rotten, has guaranteed that the reagent of splendid attire can not take place rotten in it. The material of the sealing member 4 is selected from medical grade metal foils, such as aluminum foil, which are stable and easily punctured under a certain pressure.

Based on the above, the skilled person can use the reagent vessel in the following way:

when used to contain reagents, such as lyophilized powders and vehicles, the reagent tubes are first subjected to a rigorous sterilization process to bring them to medical grade. The vehicle and the lyophilized powder are then optionally placed under sterile conditions into the upper 2 and lower 3 lids, followed by sealing of the upper 2 and lower 3 lids with a closure 4, e.g. a sealing foil. Finally, the upper cap 2 and the lower cap 3 are screwed onto the outer tube 101 until the stop 6 thereon comes into contact against the removable annular part 5. At this time, the reagent can be stored.

When the reagent is used, the removable annular component 5 is removed, and then the upper cap body 2 and the lower cap body 3 are continuously rotated until the upper cap body 2 and the lower cap body 3 are completely matched with the outer pipe 101 in a threaded manner, so that the opening of the inner pipe 102 pierces the sealing piece 4 on the upper cap body 2 and the lower cap body 3, at the moment, the freeze-dried powder and the solvent can be mixed together, and the reagent pipe can be fully mixed by fully shaking. When in use, the upper cover body 2 or the lower cover body 3 is optionally opened to take out the mixed reagent.

Therefore, the reagent tube provided by the embodiment of the invention realizes that one reagent tube simultaneously bears the freeze-dried powder and the solvent through the two-in-one design. When the mixing device is used, the reagent tube does not need to be opened, the sufficient mixing can be realized without contacting with an external environment, and the secondary pollution of the reagent is avoided. The reagent tube reduces the cost of production, transportation, disinfection and other manpower and material resources, is convenient to operate, has good sealing performance and high safety, and is convenient for large-scale popularization and application.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A reagent tube, comprising: the device comprises a pipe body with openings at two ends, an upper cover body, a lower cover body, a sealing piece and a removable annular part;

internal threads are arranged on the inner walls of the upper connecting section and the lower connecting section, external threads matched with the internal threads are arranged on the lower end of the upper cover body and the outer wall of the upper end of the lower cover body, the upper cover body and the upper connecting section as well as the lower cover body and the lower connecting section are in threaded connection, when the removable annular component is removed, the upper cover body and the lower cover body can further perform spiral motion, and the pipe orifice of the inner pipe applies pressure to the two sealing pieces so as to break the sealing pieces; the inner tube is including last puncture section, well linkage segment and the lower puncture section that communicates in order, well linkage segment with well support the section and pass through the connecting piece fixed together, go up the puncture section with go up the linkage segment and puncture section down with be provided with the clearance down between the linkage segment, the clearance is used for holding go up the lid with the wall of the cover mouth of lid down.

2. The reagent tube of claim 1, further comprising: and the two blocking parts are respectively arranged on the outer walls of the upper cover body and the lower cover body and are used for abutting against the removable annular component.

3. The reagent tube of claim 2, wherein the blocking member is an annular flange that protrudes radially outward of the upper and lower covers.

4. The reagent tube according to claim 1, wherein the outer tube and the inner tube are concentrically arranged, the upper piercing section and the lower piercing section are both tubes with a constant outer diameter and a variable inner diameter, the inner diameter of the upper piercing section is gradually increased from bottom to top, and the inner diameter of the lower piercing section is gradually increased from top to bottom.

5. The reagent tube of claim 4, wherein the upper piercing section has an outer diameter equal to an inner diameter of the upper cap and the lower piercing section has an outer diameter equal to an inner diameter of the lower cap.

6. The reagent tube of claim 1, wherein the outer walls of the upper and lower piercing sections are provided with an elastomeric coating.

7. The reagent tube of claim 1, wherein the outer walls of the upper puncture section and the lower puncture section near the end of the middle connecting section are sleeved with sealing rings.

8. The reagent tube of claim 1, wherein an outer wall of the outer tube is provided with an anti-slip structure.

9. The reagent tube of any one of claims 1-8, wherein the tube body, the upper cover body, and the lower cover body are all made of medical grade polymers;

the sealing piece is made of medical-grade metal foil.