CN109293953A - A kind of preparation method of alcohol precipitation nano-starch particle - Google Patents
A kind of preparation method of alcohol precipitation nano-starch particle Download PDFInfo
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- CN109293953A CN109293953A CN201811078656.XA CN201811078656A CN109293953A CN 109293953 A CN109293953 A CN 109293953A CN 201811078656 A CN201811078656 A CN 201811078656A CN 109293953 A CN109293953 A CN 109293953A
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2303/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
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Abstract
A kind of preparation method of alcohol precipitation nano-starch particle: starch is added in water and forms starch suspension；Starch suspension is placed in ice-water bath vessel and moves into ultrasonic cell disruptor and carries out miniaturization processing, centrifugation freeze-drying；Starch after drying is dissolved in urea/sodium hydroxide mixed solution, magnetic agitation to starch is completely dissolved；Step solution is taken, is added dropwise in dehydrated alcohol, ultrasonic vibration is centrifuged, and is washed, freeze-drying, and primary nano-starch particle is formed；It takes primary nano-starch particle soluble in water, forms nano-starch solution；Surfactant is added in the nano-starch solution；The solution that step is ultimately formed is taken, is added dropwise in dehydrated alcohol, magnetic agitation is centrifuged, and washing is freeze-dried to get nano-starch particle.Equipment needed for this method is simple, and operating procedure is few, and no poisonous and harmful waste liquid generates, environmentally friendly, and granularity is small and distribution is concentrated.
Description
Technical field
The present invention relates to a kind of preparation methods of nano-starch particle, and in particular to a kind of to prepare nanometer using alcohol precipitation technology
The method of starch granules.
Background technique
Nanotechnology rise in the 1990s, be related to the microscopic fields based on atom, molecule, it is microcosmic with it is macroscopical
Transition region and mankind's activity macrocosm.Nanotechnology in a short time get up by fast development, to old traditional technology
The impact of essence is caused, one of the popular new and high technology of current scholar's research is become.Nano particle is as nanotechnology
Branch field has obtained centainly because it has well-regulated shape, uniform size and apparent scale effect in many industries
Using and embodied good market prospects.
China is the major producing country of starch, and most of starch is used directly to eat, and the grain storage proportion of goods damageds are high, is caused serious
The wasting of resources and huge economic loss.
Existing common starch particle is larger, and flexibility is poor, and processing difficulties, added value is low, significantly limits answering for starch
Use range.Therefore, research and develop the high added value new product being made from starch becomes focus concerned by people again.
Nano-starch because having small-size effect, skin effect and quantum size effect, and has wide development and utilization
Value.
Nano-starch is from a wealth of sources, and biocompatibility and biological degradability are good, and nontoxic and non-immunogenicity can be applied to receive
The fields such as rice packing material, coated paper coatings, emulsifier and biological medicine.Wherein nano-starch is carried as a kind of newtype drug
Body has medicament slow release and targeted release performance, can effectively extend the action time of drug, improves drug utilization efficiency, carrier
Itself any reaction toxicity is nearly no detectable to organism, is ideal carrier material.
The preparation method of existing nano-starch is broadly divided into physical method, chemical method and biological enzyme three categories.
Physical method mainly has mechanical milling method, high pressure homogenization method and supercritical ultrasonics technology, and nano-starch made from such methods is deposited
Grain shape is irregular, granularity is big, the wide disadvantage of size distribution ranges.
Chemical method includes acid-hydrolysis method and alkali freezing, and that there are product recovery rates is low for such methods, has waste liquid output, to ring
The shortcomings that border pollutes.
Biological enzyme is to be carried out using hydrolysis amylase to ɑ -1,4- glycosidic bond in the allotment chain of starch and ɑ -1,6 glycosidic bond
It destroys, so that long linear starch is become short amylose, effectively reduce the granule size of starch granules really to a certain extent,
But it is at high cost, reaction environment is required stringent.
" preparation and property research of amylose nano particle " (" Jilin University's master thesis ", Dong Yan) text report
A kind of method for preparing nano particle using the precipitation method in road, required instrument is simple, and operating procedure is few, is a kind of more satisfactory
The preparation method of nano-starch.But there is also following disadvantages for this method: organic solvent dimethyl sulfoxide is to human skin used in 1.
There is permeability, and have great stimulation to eyes, improper use can cause the damage on body to operator；2. having
Poisonous and harmful waste liquid generates, and impacts to environment；3. although agglomeration is serious granularity can achieve Nano grade, lead
Cause particle generally bigger than normal.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a kind of alcohol precipitation nano-starch
The preparation method of grain.Not only required equipment is simple for the method for the present invention, and operating procedure is few, and safe operation, no poisonous and harmful useless
Liquid generates, and environmentally friendly, product granularity obtained is small, and is distributed and concentrates.
The technical solution adopted by the present invention to solve the technical problems is as follows: a kind of preparation side of alcohol precipitation nano-starch particle
Method, comprising the following steps:
(1) starch is soluble in water, it is configured to starch suspension；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, and centrifugation takes precipitating, is freeze-dried；
(3) starch after taking drying described in step (2) is dissolved in urea/sodium hydroxide mixed solution, magnetic agitation to starch
It is completely dissolved, solution is in stable translucent；
(4) starch solution for taking the translucent in step (3), is added dropwise in dehydrated alcohol, ultrasonic vibration, centrifugation,
Precipitating is taken, is washed with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing, freeze-drying forms primary nano-starch particle；
(5) it takes primary nano-starch particle described in step (4) soluble in water, forms nano-starch solution；It forms sediment in the nanometer
Surfactant is added in powder solution and stirs evenly；
(6) solution for taking step (5) to be ultimately formed, is added dropwise in dehydrated alcohol, magnetic agitation, and centrifugation takes precipitating, uses
Dehydrated alcohol washing, the precipitating of dehydrated alcohol of learning from else's experience washing, is freeze-dried to get nano-starch particle.
Preferably, in step (1), the starch be cornstarch, potato starch, rice starch, tapioca and
Using them as one of soluble starch prepared by raw material.
Preferably, step (1), in (5), the water is distilled water.
Preferably, step (1), in (5), the concentration of the starch suspension is 1%~10%.
Preferably, in step (2), the program of the ultrasonic cell disruptor is set as interval 2s, and work 2s, total working
As one cycle, every circulation primary replaces an ice-water bath by 30~180min of Shi Changwei, operating time 30min, observes in real time
Temperature, the temperature of guarantee system are no more than 45 DEG C during whole operation.
Preferably, in step (3), the mass percentage concentration of urea is 0.9% in the urea/sodium hydroxide mixed solution
~1.1%, the mass percentage concentration of sodium hydroxide is 0.5%~1.5%.
Preferably, in step (4), 1~4ml of translucent solution is drawn；It is added dropwise to the anhydrous second of 10~40ml
In alcohol, the sonic oscillation power is 360~600W；The sonic oscillation time is 3~5h；It is described to be with dehydrated alcohol washing times
3~5 times.
Preferably, in step (5), the surfactant is sorbitan fatty ester 80(span80), dehydration
Sorbitan fatty acid ester 20(span20), sorbitan fatty ester 40(span40), sorbitan fatty acid
Ester 60(span60), sorbitan fatty ester 85(span85) one of.
The invention has the following advantages: the method that 1) present invention is combined using physical method and chemical method, first with
Ultrasonic cell disruptor carries out miniaturization processing to starch granules, so that starch granules is reached Nano grade by chemical method afterwards,
Single means product particle size disadvantage bigger than normal is made up, prior art is made to advanced optimize upgrading；2) present invention uses surface-active
Agent carrys out dispersion product, it is suppressed that re-form and the mutual suction-operated of nano-starch particle hydrogen bond alleviate to a certain extent
The serious problem of agglomeration；3) product particle size of the present invention is controllable and distribution is concentrated, and does not change ative starch structure, can be used for giving birth to
Object medicine and other fields；4) equipment needed for the present invention is simple, and operating procedure is few, consumes energy low, highly-safe, can carry out large-scale industry
Metaplasia produces；5) present invention is generated without poisonous and harmful waste liquid, environmentally friendly；6) present invention uses common starch for basic former material
Material, from a wealth of sources, cheap, non-immunogenicity, biological degradability are good.
Detailed description of the invention
Fig. 1 (a) is the scanning electron microscope (SEM) photograph of Raw Materials Rice starch, and Fig. 1 (b) is that product nano-starch particle is made in embodiment 1
Scanning electron microscope (SEM) photograph.
Fig. 2 is the grain size distribution that product nano-starch particle is made in the present invention obtained according to Fig. 1 (b) statistics.
Fig. 3 is that the infrared of product object nano-starch particle is made in raw material rice starch and the present invention in the embodiment of the present invention 1
Spectrum comparison diagram, wherein curve a is the infrared spectrogram of Raw Materials Rice starch, and curve b is the obtained product nano-starch of the present invention
The infrared spectrogram of particle.
Fig. 4 is the X-ray of raw material rice starch and the obtained product nano-starch particle of the present invention in the embodiment of the present invention 1
Diffraction comparison diagram, wherein curve a is the x-ray diffraction pattern of Raw Materials Rice starch, and curve b is that the obtained product nanometer of the present invention is formed sediment
The x-ray diffraction pattern of powder particles.
Specific embodiment
Invention is further described in detail with attached drawing with reference to embodiments.
Embodiment 1:
(1) starch is dissolved in distilled water, is configured to the starch suspension that mass fraction is 10%；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, and program is set as interval 2s, and work 2s, when total working a length of 60min, every 30min replacement one
Secondary ice-water bath, centrifugation, takes precipitating, is freeze-dried；
(3) taking in (2) the dry starch 0.1g finished to be dissolved in urea/sodium hydroxide of 10mL, (mass percentage concentration is respectively
1wt%/0.8wt%) in mixed solution, magnetic agitation to starch is completely dissolved, and solution is in the translucent of stable homogeneous；
(4) the starch solution 1mL in (3) is drawn with rubber head dropper, is added dropwise in the dehydrated alcohol of 20mL, is in power
Ultrasonic vibration 3h under the conditions of 480W, centrifugation, takes precipitating, is washed 3 times with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing, cold
Dry, the primary nano-starch particle of formation is lyophilized；
(5) primary nano-starch particle described in step (4) is taken to be dissolved in the nano-starch for forming that mass fraction is 1% in distilled water
Solution；Span80 is added in the nano-starch solution and stirs evenly, wherein the mass fraction of span80 in the solution is
4%；
(6) solution for taking 1ml step (5) to be ultimately formed, is added dropwise in 20ml dehydrated alcohol, is stirred with 200r/min magnetic force
30min is mixed, is centrifuged, is taken precipitating, washed with dehydrated alcohol, precipitating is taken, is freeze-dried to get nano-starch particle.
The Raw Materials Rice starch and the nano-starch particle made from the method for the present invention that present inventor uses embodiment produce
The character of product uses scanning electron microscope, infrared spectrometer, x-ray diffractometer to carry out contrasting detection respectively, uses wherein implementing 1
The testing result of Raw Materials Rice starch and the nano-starch grain products made from the method for the present invention is as shown in Figs 1-4.
Wherein Fig. 1 (a) is the Raw Materials Rice starch and nano-starch product obtained scanning electricity of 1 use of the embodiment of the present invention
Mirror figure, Raw Materials Rice starch granules is oval as shown in Fig. 1 (a), and surface is smooth, clear-cut, and average grain diameter is at 3~5 μm；
Fig. 1 (b) is nano-starch made from embodiment 1, even particle size.
The grain size distribution of nano-starch particle according to Fig.2, it is known that, centralized particle diameter, average grain diameter is about
32nm。
According to the infrared spectrum comparison diagram of Fig. 3 it is found that nano-starch particle (b curve) and raw starch obtained by the present embodiment
The infared spectrum of (a curve) is almost the same, and not new peak occurs, and shows not introduce other functional groups, nano-starch is still protected
The fundamental characteristics for holding raw starch, not by external environmental.
According to the X-ray diffraction comparison diagram of Fig. 4 it is found that 2 θ of Raw Materials Rice starch nearby exists in 15 °, 17 °, 19 °, 23 °
Apparent characteristic diffraction peak is A type structure, and only the existing characteristics peak near 19 °, crystal structure change curve b2 θ, crystallinity
Decline.
Embodiment 2:
(1) starch is dissolved in distilled water, is configured to the starch suspension that mass fraction is 9%；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, and program is set as interval 2s, and work 2s, when total working a length of 150min, every 30min replacement one
Secondary ice-water bath, centrifugation, takes precipitating, is freeze-dried；
(3) taking in (2) the dry starch 0.5g finished to be dissolved in urea/sodium hydroxide of 10mL, (mass percentage concentration is respectively
1wt%/1.5wt%) in mixed solution, magnetic agitation to starch is completely dissolved, and solution is in the translucent of stable homogeneous；
(4) the starch solution 1mL in (3) is drawn with rubber head dropper, is added dropwise in the dehydrated alcohol of 20mL, is in power
Ultrasonic vibration 3.5h under the conditions of 480W, centrifugation, takes precipitating, is washed 4 times with dehydrated alcohol, takes precipitating, and freeze-drying forms primary
Nano-starch particle；
(5) primary nano-starch particle described in step (4) is taken to be dissolved in the nanometer shallow lake for forming that mass fraction is 0.9% in distilled water
Powder solution；Span20 is added in the nano-starch solution and stirs evenly, wherein the mass fraction of span20 in the solution
It is 6%；
(6) solution for taking 1ml step (5) to be ultimately formed, is added dropwise in 20ml dehydrated alcohol, is stirred with 400r/min magnetic force
30min is mixed, is centrifuged, is taken precipitating, washed with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing, freeze-drying is to get nanometer shallow lake
Powder particles product.
The nano-starch mean particle size being prepared in the present embodiment is 150nm, and particle diameter distribution is uniform.
Embodiment 3:
(1) starch is dissolved in distilled water, is configured to the starch suspension that mass fraction is 5%；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, program is set as interval 2s, and work 2s, when total working a length of 30min, centrifugation takes precipitating,
Freeze-drying；
(3) taking in (2) the dry starch 0.5g finished to be dissolved in urea/sodium hydroxide of 10mL, (mass percentage concentration is respectively
1wt%/0.5wt%) in mixed solution, magnetic agitation to starch is completely dissolved, and solution is in the translucent of stable homogeneous；
(4) the starch solution 1mL in (3) is drawn with rubber head dropper, is added dropwise in the dehydrated alcohol of 30mL, is in power
Ultrasonic vibration 4h under the conditions of 400W, centrifugation, takes precipitating, is washed 3 times with dehydrated alcohol, takes precipitating, and freeze-drying forms primary and receives
Rice starch particle；
(5) primary nano-starch particle described in step (4) is taken to be dissolved in the nanometer shallow lake for forming that mass fraction is 1.1% in distilled water
Powder solution；Span40 is added in the nano-starch solution and stirs evenly, wherein the mass fraction of span40 in the solution
It is 8%；
(6) solution for taking 1ml step (5) to be ultimately formed, is added dropwise in 20ml dehydrated alcohol, is stirred with 400r/min magnetic force
30min is mixed, is centrifuged, is taken precipitating, washed with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing, freeze-drying is to get nanometer shallow lake
Powder particles product.
The nano-starch mean particle size being prepared in the present embodiment is 220nm, and particle diameter distribution is uniform.
Embodiment 4:
(1) starch is dissolved in distilled water, is configured to the starch suspension that mass fraction is 8%；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, program is set as interval 2s, and work 2s, when total working a length of 60min, every 30min replacement one
Secondary ice-water bath, centrifugation, takes precipitating, is freeze-dried；
(3) taking in (2) the dry starch 0.1g finished to be dissolved in urea/sodium hydroxide of 10mL, (mass percentage concentration is respectively
1wt%/1.2wt%) in mixed solution, magnetic agitation to starch is completely dissolved, and solution is in the translucent of stable homogeneous；
(4) the starch solution 1mL in (3) is drawn with rubber head dropper, is added dropwise in the dehydrated alcohol of 10mL, is in power
Ultrasonic vibration 4.5h under the conditions of 400W, centrifugation, takes precipitating, is washed 4 times with dehydrated alcohol, takes precipitating, and freeze-drying forms primary
Nano-starch particle；
(5) primary nano-starch particle described in step (4) is taken to be dissolved in the nano-starch for forming that mass fraction is 1% in distilled water
Solution；Span80 is added in the nano-starch solution and stirs evenly, wherein the mass fraction of span80 in the solution is
4%；
(6) solution for taking 1ml step (5) to be ultimately formed, is added dropwise in 20ml dehydrated alcohol, is stirred with 200r/min magnetic force
30min is mixed, is centrifuged, is taken precipitating, washed 3 times with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing is freeze-dried to get receiving
Rice starch grain products.
The nano-starch mean particle size being prepared in the present embodiment is 81nm, and particle diameter distribution is uniform.
Embodiment 5:
(1) starch is dissolved in distilled water, is configured to the starch suspension that mass fraction is 7%；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, and program is set as interval 2s, and work 2s, when total working a length of 90min, every 30min replacement one
Secondary ice-water bath, centrifugation, takes precipitating, is freeze-dried；
(3) take in (2) the dry starch 0.1g finished be dissolved in 10mL urea/sodium hydroxide (mass percentage concentration be respectively 1wt%/
1wt%) in mixed solution, magnetic agitation to starch is completely dissolved, and solution is in the translucent of stable homogeneous；
(4) the starch solution 1mL in (3) is drawn with rubber head dropper, is added dropwise in the dehydrated alcohol of 40mL, is in power
Ultrasonic vibration 3h under the conditions of 400W, centrifugation, takes precipitating, is washed 3 times with dehydrated alcohol, takes precipitating, and freeze-drying forms primary and receives
Rice starch particle；
(5) primary nano-starch particle described in step (4) is taken to be dissolved in the nanometer shallow lake for forming that mass fraction is 1.1% in distilled water
Powder solution；Span60 is added in the nano-starch solution and stirs evenly, wherein the mass fraction of span60 in the solution
It is 8%；
(6) solution for taking 1ml step (5) to be ultimately formed, is added dropwise in 20ml dehydrated alcohol, is stirred with 200r/min magnetic force
30min is mixed, is centrifuged, is taken precipitating, washed 4 times with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing is freeze-dried to get receiving
Rice starch grain products.
The nano-starch mean particle size being prepared in the present embodiment is 144nm, and particle diameter distribution is uniform.
The present invention is not limited only to above-described embodiment, and increase, the replacement made within the essential scope of the present invention should also belong to
In protection scope of the present invention.
Claims (8)
1. a kind of preparation method of alcohol precipitation nano-starch particle, which comprises the following steps:
(1) starch is soluble in water, it is configured to starch suspension；
(2) starch suspension in step (1) is placed in ice-water bath vessel, the ice-water bath vessel is moved into supersonic cell
Pulverizer carries out miniaturization processing, and centrifugation takes precipitating, is freeze-dried；
(3) starch after taking drying described in step (2) is dissolved in urea/sodium hydroxide mixed solution, magnetic agitation to starch
It is completely dissolved, solution is in stable translucent；
(4) starch solution for taking the translucent in step (3), is added dropwise in dehydrated alcohol, ultrasonic vibration, centrifugation,
Precipitating is taken, is washed with dehydrated alcohol, the precipitating of dehydrated alcohol of learning from else's experience washing, freeze-drying forms primary nano-starch particle；
(5) it takes primary nano-starch particle described in step (4) soluble in water, forms nano-starch solution；It forms sediment in the nanometer
Surfactant is added in powder solution and stirs evenly；
(6) solution for taking step (5) to be ultimately formed, is added dropwise in dehydrated alcohol, magnetic agitation, and centrifugation takes precipitating, uses
Dehydrated alcohol washing, the precipitating of dehydrated alcohol of learning from else's experience washing, is freeze-dried to get nano-starch particle.
2. the preparation method of alcohol precipitation nano-starch particle according to claim 1, it is characterised in that: in step (1), the shallow lake
Powder be cornstarch, potato starch, rice starch, tapioca and using them as raw material prepared by soluble starch
One kind.
3. the preparation method of alcohol precipitation nano-starch particle according to claim 1 or claim 2, which is characterized in that the water is distillation
Water.
4. the preparation method of alcohol precipitation nano-starch particle according to claim 1 to 3, which is characterized in that starch suspension
Concentration is 1%~10%.
5. the preparation method of -4 any alcohol precipitation nano-starch particles according to claim 1, it is characterised in that: in step (2),
The program of the ultrasonic cell disruptor is set as interval 2s, and work 2s, when total working a length of 30~180min, operating time
30min replaces an ice-water bath as one cycle, every circulation primary, and real-time observed temperature, the temperature of guarantee system is entire
It is no more than 45 DEG C in operating process.
6. the preparation method of -5 any alcohol precipitation nano-starch particles according to claim 1, it is characterised in that: in step (3),
The mass percentage concentration of urea is 0.9%~1.1% in the urea/sodium hydroxide mixed solution, the quality percentage of sodium hydroxide
Concentration is 0.5%~1.5%.
7. the preparation method of -6 any alcohol precipitation nano-starch particles according to claim 1, it is characterised in that: in step (4),
Draw 1~4ml of translucent solution；It is added dropwise in the dehydrated alcohol of 10~40ml, the sonic oscillation power is 360
~600W；The sonic oscillation time is 3~5h；The use dehydrated alcohol washing times are 3~5 times.
8. the preparation method of -7 any alcohol precipitation nano-starch particles according to claim 1, it is characterised in that: in step (5),
The surfactant is sorbitan fatty ester 80, sorbitan fatty ester 20, Sorbitan alcohol ester
One of fat acid esters 40, sorbitan fatty ester 60, sorbitan fatty ester 85.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110845746A (en) * | 2019-11-25 | 2020-02-28 | 西北农林科技大学 | Preparation method of nano starch |
| CN110974846A (en) * | 2019-12-30 | 2020-04-10 | 内蒙古医科大学 | Method for separating nano-structure component from Mongolian medicine borneol and obtained nano-structure component |
| CN113621142A (en) * | 2021-08-02 | 2021-11-09 | 南京中医药大学 | Specific-morphology nano starch with efficient urea adsorption function and preparation method and application thereof |
| CN113896910A (en) * | 2021-09-15 | 2022-01-07 | 广州光驭超材料有限公司 | Nano starch-based microgel microspheres and preparation method and application thereof |
| CN115739056A (en) * | 2022-11-23 | 2023-03-07 | 西北农林科技大学 | Nano material for separating polyphenol in plant extract, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104004134A (en) * | 2014-05-30 | 2014-08-27 | 西华大学 | Preparation method of grain size controllable monodisperse nano starch microspheres |
| CN105199116A (en) * | 2015-10-22 | 2015-12-30 | 吉林大学 | Starch nanoparticle sedimentation preparation method through treatment of starch water solution by adopting ultrasonic wave |
-
2018
- 2018-09-17 CN CN201811078656.XA patent/CN109293953A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104004134A (en) * | 2014-05-30 | 2014-08-27 | 西华大学 | Preparation method of grain size controllable monodisperse nano starch microspheres |
| CN105199116A (en) * | 2015-10-22 | 2015-12-30 | 吉林大学 | Starch nanoparticle sedimentation preparation method through treatment of starch water solution by adopting ultrasonic wave |
Non-Patent Citations (2)
| Title |
|---|
| SUK FUN CHIN ET AL.: "Size controlled synthesis of starch nanoparticles by a simple nanoprecipitation method", 《CARBOHYDRATE POLYMERS》 * |
| 孙锦等: "淀粉纳米颗粒的制备及其作为药物载体的研究进展", 《现代化工》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110845746A (en) * | 2019-11-25 | 2020-02-28 | 西北农林科技大学 | Preparation method of nano starch |
| CN110974846A (en) * | 2019-12-30 | 2020-04-10 | 内蒙古医科大学 | Method for separating nano-structure component from Mongolian medicine borneol and obtained nano-structure component |
| CN113621142A (en) * | 2021-08-02 | 2021-11-09 | 南京中医药大学 | Specific-morphology nano starch with efficient urea adsorption function and preparation method and application thereof |
| CN113621142B (en) * | 2021-08-02 | 2024-02-23 | 南京中医药大学 | Nano starch with specific morphology and high-efficiency urea adsorption function, and preparation method and application thereof |
| CN113896910A (en) * | 2021-09-15 | 2022-01-07 | 广州光驭超材料有限公司 | Nano starch-based microgel microspheres and preparation method and application thereof |
| CN113896910B (en) * | 2021-09-15 | 2022-06-24 | 广州光驭超材料有限公司 | Nano starch-based microgel microspheres and preparation method and application thereof |
| CN115739056A (en) * | 2022-11-23 | 2023-03-07 | 西北农林科技大学 | Nano material for separating polyphenol in plant extract, preparation method and application |
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