CN109293501A - The synthetic method of zinc gluconate - Google Patents
The synthetic method of zinc gluconate Download PDFInfo
- Publication number
- CN109293501A CN109293501A CN201811143254.3A CN201811143254A CN109293501A CN 109293501 A CN109293501 A CN 109293501A CN 201811143254 A CN201811143254 A CN 201811143254A CN 109293501 A CN109293501 A CN 109293501A
- Authority
- CN
- China
- Prior art keywords
- zinc
- zinc gluconate
- gluconic acid
- reaction
- synthetic method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 title claims abstract description 28
- 239000011670 zinc gluconate Substances 0.000 title claims abstract description 24
- 229960000306 zinc gluconate Drugs 0.000 title claims abstract description 24
- 235000011478 zinc gluconate Nutrition 0.000 title claims abstract description 24
- 238000010189 synthetic method Methods 0.000 title claims abstract description 12
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 17
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 15
- 239000000174 gluconic acid Substances 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 13
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims abstract description 8
- 239000013078 crystal Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 239000011701 zinc Substances 0.000 claims description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 7
- 239000002994 raw material Substances 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 5
- 238000005265 energy consumption Methods 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 238000001291 vacuum drying Methods 0.000 abstract description 3
- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 abstract description 2
- 238000003746 solid phase reaction Methods 0.000 abstract description 2
- 238000001694 spray drying Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 6
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 3
- 239000004570 mortar (masonry) Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- -1 stirs evenly Substances 0.000 description 2
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 2
- 229940007718 zinc hydroxide Drugs 0.000 description 2
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000019543 dairy drink Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 229940091251 zinc supplement Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of synthetic methods of zinc gluconate, and using gluconic acid solution and basic carbonate zinc powder as raw material, zinc gluconate white crystals are can be obtained until the moisture in reaction mass is evaporated in hybrid reaction under heating conditions.The mass concentration of the gluconic acid solution is 70-75%；The molar ratio of gluconic acid and basic zinc carbonate is 6:1 when reaction.The present invention passes through will be using gluconic acid solution and basic carbonate zinc powder as raw material, directly reacted when heated, process flow is simple, solid phase reaction water consumption is few, and reaction temperature is lower, low energy consumption, and is dried while heating, and border ring drying in side avoids the highly energy-consumings drying process such as spray drying or vacuum drying.
Description
Technical field
A kind of medical material technical field of the present invention, and in particular to synthetic method of zinc gluconate.
Background technique
Zinc gluconate is organic zinc tonic, small to stomach lining stimulation, is easily absorbed by the body in vivo, and absorptivity is high,
Dissolubility is good.It is widely used in health care product, medicine and food, has to baby and teen-age intelligence and body development important
Effect, assimilation effect are better than inorganic zinc.China's regulation can be used in salt, dairy products, drink and milk beverage.It is simultaneously also one kind
Medicine and fine chemicals.It can participate in the synthesis of nucleic acid and protein, enhance human immunological competence, promote tire, baby, You Ersheng
Long development.It is medical zinc supplementation reagent.It is used as nutritional supplement (zinc enhancer) in the food industry, can be added in milk replacer.
Zinc gluconate is as a kind of important Zinc supplements.It can be that raw material carries out with zinc hydroxide with gluconic acid
Production.At present in producing country mainstream production using glucose as raw material, be fermented into Aspergillus, separated, purify after be diluted to Portugal
It is neutralized after grape saccharic acid aqueous solution with zinc hydroxide, gluconic acid zinc solution techniques such as concentrated again, by crystallizing and drying, spraying dry
Dry or vacuum drying method obtains zinc gluconate finished product.
The disadvantages of that there are processing steps is more for aforementioned production method, water consumption is big and the methods of vacuum concentration energy consumption is high.
Summary of the invention
In order to solve the above technical problem, the present invention provides a kind of synthetic method of zinc gluconate, this method can subtract
Water consumption and energy consumption in few zinc gluconate production process, improve production efficiency, reduce production cost.
The technical solution adopted by the present invention is that a kind of synthetic method of zinc gluconate, which is characterized in that with gluconic acid
Solution and basic carbonate zinc powder are raw material, under heating conditions hybrid reaction, until the moisture in reaction mass is evaporated, i.e.,
Zinc gluconate white crystals can be obtained.
Further, the mass concentration of the gluconic acid solution is 70-75%
Further, the molar ratio of gluconic acid and basic zinc carbonate is 6:1 when reaction.
Further, the temperature of the reaction is 50-80 DEG C, reaction time 6-8h.
Further, the reaction temperature is 70-75 DEG C.
Further, moisture content is controlled in 20-40% in the zinc gluconate white crystals.
The present invention using gluconic acid solution and basic carbonate zinc powder as raw material by will directly carry out when heated anti-
It answers, process flow is simple, and solid phase reaction water consumption is few, and reaction temperature is lower, and low energy consumption, and is done while heating
Dry, border ring drying in side avoids the highly energy-consumings drying process such as spray drying or vacuum drying.
Specific embodiment
Below with reference to embodiment, the present invention is furture elucidated.
Embodiment 1:
Taking mass fraction is the gluconic acid solution 6mol(1681g of 70 %), the basic carbonate zinc powder (ZnCO with 1mol3Zn2
(OH)2H2O 308g) powder mixes in mortar, stirs evenly, material is placed in 8h in 50-60 DEG C of baking oven, side border ring is dry
It is dry, zinc gluconate crystal is finally obtained, obtained crystal obtains gluconic acid zinc powder after being crushed.Purity reaches 99.6%.
Embodiment 2:
Taking mass fraction is 75% gluconic acid solution 6mol(1568g), the basic carbonate zinc powder (ZnCO with 1mol3Zn2
(OH)2H2O 308g) powder mixes in mortar, stirs evenly, material is placed in 7h in 70-75 DEG C of baking oven, side border ring is dry
It is dry, zinc gluconate crystal is finally obtained, obtained crystal obtains gluconic acid zinc powder after being crushed.Purity reaches 99.8%.
Embodiment 3:
Taking mass fraction is 72% gluconic acid solution 3mol(816g), with 1mol basic carbonate zinc powder (ZnCO3Zn2(OH)2H2O 154g) it mixes in mortar, it stirs and evenly mixs.The dry 6h of material side border ring in 75-80 DEG C of baking oven obtains zinc gluconate,
Gluconic acid zinc powder is obtained after crushing.Purity reaches 99.5%.
The above embodiments are only the preferred technical solution of the present invention, and are not construed as limitation of the invention, this hair
Bright protection scope should be with the technical solution of claim record, technical characteristic in the technical solution recorded including claim
Equivalents are protection scope.Equivalent replacement i.e. within this range is improved, also within protection scope of the present invention.
Claims (6)
1. a kind of synthetic method of zinc gluconate, which is characterized in that with gluconic acid solution and basic carbonate zinc powder be original
Material, zinc gluconate white knot can be obtained until the moisture in reaction mass is evaporated in hybrid reaction under heating conditions
It is brilliant.
2. the synthetic method of zinc gluconate according to claim 1, it is characterised in that: the quality of the gluconic acid solution
Concentration is 70-75%.
3. the synthetic method of zinc gluconate according to claim 1, it is characterised in that: gluconic acid and alkali formula carbon when reaction
The molar ratio of sour zinc is 6:1.
4. the synthetic method of zinc gluconate according to claim 1, it is characterised in that: the temperature of the reaction is 50-80
DEG C, reaction time 6-8h.
5. the synthetic method of zinc gluconate according to claim 1, it is characterised in that: the reaction temperature is 70-75 DEG C.
6. the synthetic method of zinc gluconate according to claim 1, it is characterised in that: the zinc gluconate white crystals
Middle moisture content control is in 20-40%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811143254.3A CN109293501A (en) | 2018-09-28 | 2018-09-28 | The synthetic method of zinc gluconate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811143254.3A CN109293501A (en) | 2018-09-28 | 2018-09-28 | The synthetic method of zinc gluconate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109293501A true CN109293501A (en) | 2019-02-01 |
Family
ID=65164970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811143254.3A Withdrawn CN109293501A (en) | 2018-09-28 | 2018-09-28 | The synthetic method of zinc gluconate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109293501A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104326932A (en) * | 2014-10-09 | 2015-02-04 | 中国食品发酵工业研究院 | Method for low temperature solid-phase synthesis of zinc aspartate |
-
2018
- 2018-09-28 CN CN201811143254.3A patent/CN109293501A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104326932A (en) * | 2014-10-09 | 2015-02-04 | 中国食品发酵工业研究院 | Method for low temperature solid-phase synthesis of zinc aspartate |
Non-Patent Citations (1)
| Title |
|---|
| 郑筱萸 等: "《药学前沿》", 31 July 2004, 中国医药科技出版 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190201 |
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| WW01 | Invention patent application withdrawn after publication |