CN109289124A - Device in spine recovering system for neuromere interference - Google Patents
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- CN109289124A CN109289124A CN201811077741.4A CN201811077741A CN109289124A CN 109289124 A CN109289124 A CN 109289124A CN 201811077741 A CN201811077741 A CN 201811077741A CN 109289124 A CN109289124 A CN 109289124A
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Abstract
Device in spine recovering system for neuromere interference.The spine recovering system is treated for the slight contracture of muscle caused by the reasons such as modern's bad life habits and disease and muscle tonue.Wherein containing there are many facilitating bone and avoid the drug of ectopic osteogenesis, the drug being discharged in tissue space selectively by special clad, and be arranged by magnetic field in affected part enrichment.For the activity for improving the drug, the present invention also increases the device for forming neuromere interference and artificial weakly alkaline environment etc..The present invention improves muscle, neurological health index by human body muscle tonue related neural section induced discharge effectively, promotes wound healing;It adjusts in combination with checking with EMG method real-time perfoming adaptivity to obtain better healing effect.In order to realize better incision opportunity during above-mentioned electric magnetic medical, instruction device prompt patient carries out abdominal respiration to cooperate magnetic therapy under control device management, avoids Evoked ptential and the cardiac electrical excessive interference of normal human.
Description
Technical field
Technical field
This application involves bone wound recoverings, especially spine recovering field, and in particular to a kind of backbone and related neural, muscle
Convalescence device.
Background technique
Modern causes body a part to be chronically at due to seat work, bad life habits and disease or certain
Anchor, muscle are chronically at the state of underload contracts last.This will lead to moisture in the fibr tissues matrix such as ligament and subtracts
Few, viscoelasticity weakens, and interfibrous lubricating action reduces.Meanwhile interfibrous hypotelorism, contact phase extend, this may lead
It causes to generate the horizontal key of chemistry between fiber, stick together so as to cause between fiber.And such crowd is often because of the chronic inflammation of muscular tissue
Disease and lead to newborn fiber, these newborn fiber alignment disorders form adhesion with original fiber again, further limit fibre
Sliding between dimension.Long it, this " vicious circle " will cause muscle that slight contracture occurs, and cause muscle tonue.The life of modern
Mode living determines that such muscle tonue mostly occurs on backbone attachment or sizes related muscle group, and long will to will lead to backbone tired
The appearance of labor, overload or even irreversible damage.It of particular concern is, most of muscular fatigues or damage are all along with correlation
The strain or hyperplasia of bone.
Pass through simultaneously in spine recovering field in implementation spinal traction, fixation and applies the alleviation muscle tonue quilt such as machinery, electric field
It is proved to be effective treatment means.But it should inevitably will cause the unnecessary damage of backbone, or even meeting in the process
(spinal cord injury, SCI) is damaged to spinal cord, and medical personnel is often reluctant to use in order to avoid SCI
Positive therapeutic scheme;And also often occur unexpectedly to press in the positive treatment means such as massage processes of non-spinal damage
Abrasion wound.So needing to provide effectively real-time electrophysiologic monitoring means when being related to spinal treatments.How electro physiology to be detected
Combining with a variety of spine recovering means is a direction that this field has much development prospect.It is obtained in numerous electrophysiological indexs
Effective and representative data are taken, and with the emphasis of its progress and this field research of instructing subsequent spine recovering.
Neuro electromyograph is to be stimulated by the energy of diversified forms, according to Nervous System Anatomy principle to organism
The technology that the electrical characteristics of bioelectricity and organism that peripheral nerve generates are measured, record and analyzed.Evoked ptential
(evoked potentials, EPs) refers to and gives nervous system (from receptor to cerebral cortex) specifically stimulation (sound, light
Or body-sensing stimulation), or process brain to the information of stimulation (positivity or negativity), in the corresponding site of the system and brain
Generate it is can detecting, have with stimulation and fix time interval (relationship when lock) and the bioelectricity of certain bits phase relatively and react.It is anti-
The integrality for having reflected cynapse transmitting, the cell of axon conduction and molecular system structure and function, is a kind of effective function
Property index.
Electromyography signal (EMG) is a kind of adjoint muscular movement and the bioelectrical signals generated.In the limb motion of people, greatly
The neuronal excitation of moving region is controlled in cortex and generates the electric pulse of certain frequency, this electric pulse passes through nervous system
Specific meat fiber is accurately conducted, when these electric pulses reach a neural muscle cynapse, soleplate is generated in muscle fibre
Current potential, its depolarising will generate a series of movements current potential in muscle fibre, and cause contraction of muscle, complete limbs set by brain
Movement.Surface EMG is each section muscle activity comprehensive physiology electrical phenomena generated in limb motion, is divided surface EMG
Analysis research can find its corresponding relationship between muscle physiological state and limb motion patterns, can be widely applied to clinical doctor
The numerous areas such as, sports medical science, medical rehabilitation.In human skeletal muscle, there are Severe Pain points in muscle muscle tonue band
The viewpoint of (myofascial trigger point, MTrP) is widely recognized as.It can recorde in the area MTrP of muscle tonue band
To spontaneous electrical activity, further, muscular tone can also be showed and is detected in the form of myoelectricity.Flesh in simple terms
Meat makes expression to its physiological status (stressing myotonic physiological status in the present invention to state) by electricity physiological signal;In turn
Adjusting appropriate can also be made to muscle tonue in such a way that impressed field influences myoelectricity.
It exists in the prior art by carrying out electro photoluminescence to patient and receiving myoelectricity/biofeedback signals of patient, thus
Reach the method and apparatus for improving muscular tone.But these devices use simple electrode stimulating, frequency be located substantially at 5Hz~
Between 100Hz, electric signal includes that waveform is simple.It is single to the effect of stimulation of human body, be easy to cause peripheral nerve fatigue and produce
Raw a large amount of unnecessary electrode heat.Insertion electrode or patch electrode then may cause skin keratin lesion and bring unnecessary damage
Wound.Patient can generate the unnecessary imagination for intuitive visible electrode stimulating, and such psychology also results in therapeutic effect deterioration.
Most importantly peripheral nerve may react good for stimulating in short term, but long-term treatment will lead to neural fatigue, and effect also can
It is plummeted.Reason is in evolutionary process that human nerve stress reflect the injury that environmental stimuli generates and have one to adapt to
Journey, subject nerves and muscles easily reach refractory period for the purpose of self-protection;And the human body including neuromere
Self neural electricity is then less prone to such fatigue, its fatigue endurance phase is longer in other words.
Neuromere be the identical neuron cell body of function other than the maincenter around nodositas structure made of the set of position
It makes.Its surface is surrounded by one layer of connective tissue membrane, wherein containing blood vessel, nerve and fat cell.Envelope and perineural outer membrane, mind
It connects together through beam film, and gos deep into neuromere the network formed in neuromere.The fiber issued by nerve cell in saving
It is distributed to the related part of body, claims postganglionic fibers.By the difference of physiology and form, neuromere can be spinal ganglion (sensibility mind
Warp knuckle) and two class of automatic ganglia.Automatic ganglia includes sympathetic and parasympathetic ganglion.Sympathetic ganglion is located at backbone
Both sides.Parasympathetic ganglion is located near institute's dominating organs or in organ walls.In neuromere, the aixs cylinder of preganglionic neuron with
Postganglionic neuron forms cynapse.Neuromere is associated by nerve fibre with brain, spinal cord, and previous people are often functionally more
Using neuromere as being terminal of the nervous centralis to infarctional.But actually inventor is surveyed by the physiology that laboratory carries out
Examination discovery: not smart in amplitude, frequency by the bioelectricity for stimulating the nervous system including neuromere that human body is caused to generate
It is really controllable, and the bioelectricity peomotes that the controlled muscle of nerve, diastole, contraction and tip are fine with having the rhythm and pace of moving things for connective tissue
The blood circulation of blood vessel.Effect of the ascending nerve fiber to brain is also led to for ganglionic stimulation simultaneously, is had in practice
The effect of reduction of patient anxiety, anxiety has certain therapeutic effect for muscle tonue caused by nerve.And it can be by various
Mode is selectively excited or specific neuromere is inhibited to occur to achieve the effect that simulate people's self neural electricity, these practices are in mind
Often there is unrivaled effect through medical domain.Such as widely applied stellate ganglion block facilitates now
Restore sympathovagal balance, mitigate pain etc..Patients with sevious craniocerebral injury is being merged in the research of limbs fracture healing state
It was found that denervation caused by craniocerebral injury can promote poroma collagen expression to increase at union initial stage, clinical manifestation is bone
Folding part stress and there is spasm, after switch to slowness paralysis.A large amount of cartilage poroma can repair rapidly damage at healing initial stage
Wound restores nerve and bone structure etc..This denervation state has good effect for union, but this field at this stage
Manufacture animal denervation model is to damage cranium brain by weight, and clinically by performing the operation, specific neuromeres certain to patient hinder
It is disconnected.There is very major operation risk and irreversible in the way, cause expendable loss to patient's body and mind.
By taking stellate ganglion block as an example, conventional art is confined to save other drug injection, not only risky but also be easy to cause
Other drug-induced side effects.The present invention provides a kind of Magnetoelectric stimulation mode, carries out specific induction work to corresponding neuromere.
It, can also while being shielded but inevitably there is a situation where being interfered with each other with electrocardiosignal in stimulating course
Improve above-mentioned interference in a manner of using electrocardio triggering magnetic stimulation circuit, this is also those skilled in the art's technology urgently to be resolved
Problem.Meanwhile how it is easy quickly and non-invasively stimulation sites are accurately positioned, be those skilled in the art without gram
The problem of clothes.Previous physical therapy practitioner presses often through experience and patient feedback positions, and both inaccuracy can also in this way
It can cause accidental injury;Certainly also it has been proposed that measured by adding electrode, but laboratory environment and clinical difference are very
Greatly, testing cost is high very high simultaneously for operator's requirement.
Summary of the invention
The present invention provides a kind of health alleviated, treated for patient spine damage, backbone fatigue and related muscle group anxiety
Complex system.The shortcomings that single spinal problems can only be directed to which overcome previous convalescence device, comprehensive a variety for the treatment of means, default
It detects and realizes intelligent therapeutic under the monitoring of program.Simultaneously as in view of the same presentation of user is that may be present a variety of pathogenic
Mechanism, the detection combined using a variety of detection means, decision logic are allowed the devices to voluntarily according to the specific feelings of user
Condition makes appropriate physical therapy.To realize spine recovering effectively, safe, unnecessary secondary damage or delay are avoided.
The convalescence device that the present invention refers to include checking with EMG method module 1, magnetic therapy module 2, massage module 3, control module 4,
Display module 5, ECG module 6 and bone fracture module 7 etc..
The present invention relates to electro physiology and electromagnetism medical domains.Myoelectricity (EMG) signal known to us, amplitude, frequency spectrum
With own characteristic: the surface EMG signal measured from body surface is usually very faint, and amplitude is usually no more than 5mV;Frequency also compares
Lower, spectral range is generally 0.02-1000Hz, and spectrum energy is concentrated mainly between 0.25~350Hz.The relaxation of muscle
There are good linear relationships between tensity and generation surface myoelectric voltage amplitude.Myoelectricity voltage magnitude is measured to use
Root method can not only reflect the variation characteristic of EMG signal amplitude on time dimension, but also depend on muscle load sexual factor and flesh
Inner link between the physiology of meat itself, biochemical process, therefore, the time-domain analysis index be commonly used in real time, it is not damaged
Ground reflects muscle activity state, has preferable real-time.Meanwhile the impedance of human muscle part can effectively state human body and put
Loose degree, in general human body are more loosened, and impedance is smaller.Therefore combine using the above method can in real time, accurately obtain human body
Muscular tone degree, and it is classified.
Obtained muscle tonue degree may include much information, for example bone injury, nerve caused by backbone strain, hyperplasia etc.
Damage, pain, and the muscular tone as caused by external force or psychology caused by lactic acid metabolism imbalance and muscle cramp etc..Such as
Fruit, which cannot effectively be distinguished, leads to myotonic different reasons, then cannot effectively carry out immunotherapy targeted autoantibody.The present invention passes through in body surface
Specific region setting electromyographic signal acquisition device obtains the real-time myoelectricity of human body, impedance signal, while by can real-time live programming
Preset program in gate control logic circuit realizes identification and classification for above-mentioned electromyography signal exception inducement, and according to difference
Judging result carries out the combinations of different treatment means.
Firstly, first implementing transcranial magnetic stimulation (TMS) to user, selected stimulated zone is located at Epidural cavity, is lured by magnetic field
Send out potentiometric detection.Simple magnetic stimulator is by DC power supply, charging circuit, energy-storage travelling wave tube, discharge switch, charge-discharge control circuit
With a few part compositions such as coil.Various transcranial magnetic stimulation instruments well known to those skilled in the art and the control mould including software
Block pass through reference be introduced into the DTMS transcranial magnetic stimulation circuit device recorded in the present invention, such as US2008200749A or
The U.S.'s Medtronic Mag Pro type magnetic stimulator being commercialized.
Using the excitement that Neural stem cell cortical motor area generates, spinal cord anterior horn cell or surrounding mind are made by downlink conduction path
It is depolarized through motor fiber, is Motion Evoked Potential detection thorn in the potential change that respective muscle, nerve, spinal cord are recorded
Swash.According to different stimulus modalities, SRPs can be divided into sensory evoked potential (somatosensory evoked potential,
) and Motion Evoked Potential (motion evoked potential, MEP) SEP.SEP mainly reflects the conduction of spinal cord back side uplink
Feel the function status of access, and the MEP stimulated through cranium then reflects the integrality of ventral side of spinal cord downward movement conduction path.By
MEP helps to detect whether backbone has substantive damage, has particularly with the latent lesion for not embodying obvious physical handicaps
There is preferable flaw detection effect.The research of Maerten, Dvorak et al. are pointed out, in vertebral disease and the protrusion of the intervertebral disc,
The sensibility of MEP is 84%, and 36% compared with SEP obviously increases, and MEP is slightly above Lumbar Vertebral Canal to the sensibility of spinal canal stenosis
It is narrow.Supposition is small in size with cervical spinal canal, is easier to caused by compressing spinal cord after narrow.Machida has then reported external through cranium induction MEP
The sensibility of wound property patients with spinal cord injury is 85%.In order to reach stimulation location by skull and scalp etc., pass through coil turn
Selection with current value, generally should be between 1-2T so that peak magnetic field is not smaller than 1 tesla (T).In user's skull
Top tangentially relationship setting plate circular coil (its field stimulation is larger, is more suitable for peripheral nerve) therewith, can be iron core
Coil or built-up coil, coil diameter is between 12-20 centimetres, and hub of a spool is away from user crown distance less than 3.5 centimetres.Cause
It is used only for physiological detection, therefore action time is short, using natural cooling or air cooling way.Via the coil in user's cranium
The time-varying magnetic field frequency that 1-3 centimetres of depth realizes that fast frequency TMS namely changing currents with time generate in bone is greater than 1Hz.Using common
The detection for transcranial magnetic stimulation MEP signal can be realized in motor potential detector, big by analyzing its conduction time and signal
Small equal conventional indexs detect a flaw for spinal cord conduction path.Such situation should strictly forbid the machine for affected part or region of interest
Tool massage, avoids subsequent massage step from generating secondary damage for vertebra.
Secondly, can also be detected to periphery Nervous pathway by MEP.The MEP(of peripheral nerve is alternatively referred to as
MEPs acquisition methods) are similar with existing SEP technology, by the way that the anode of patch leading electrode is arranged in targeted muscles abdomen to be measured,
And cathode is set in neural downlink tendon section, it is ensured that distance is on 35mm between electrode.Subcutaneous micropin can be used instead when necessary
Electrode improves picking up signal effect and avoids noise jamming.Can be stated simultaneously according to patient master, in specific limbs nerve pathway or
Neuromere carries out MEP picking up signal, and then targetedly pays close attention to the myoelectricity wave conducted via specific spinal levels, can be right
Observational measurement is carried out and there is damage in specific nerve pathway.The selection of the targeted muscles is with this field transcranial magnetic stimulation signal detection
Conventional selection standard, in principle with far from trunk four limbs major muscles at be preferred, be not limited to wherein.
In the detected waveform signal of MEP, the single-phase positive phase wave of first quickly reached is known as ground wave (D wave),
Because its conduction is transmitted without cynapse, so also referred to as ground wave;And occur one group of positive wave (I wave) after D wave, it is contact
Caused by fiber indirect excitation pyramidal cell, referred to as indirect wave.Electro photoluminescence draws MEP waveform and prompts spinal cord conductive beam function normal,
And waveform disappearance shows that conduction function blocks, i.e. " all or none " or the decision principle of decreased amplitude 80%, monitors susceptibility
Up to 100%.If there is D wave block, classification will be made by gating circuit, for be likely to occur spinal cord injury forbid into
Row mechanical massage prevents that treatment is caused to injure.And it is normal in the conduction of D wave, and I wave incubation period lengthens that (criterion is substantially just
On 1.5 times of Chang Shichang) imply that there are peripheral nerve inflammation or damages, such as overwork etc. to lead to demyelinate symptom etc., at this time
It is transferred to neural bone wound recovering operating mode 2-3.Clinical trial shows in patient without under anesthesia waking state, above twice in succession
Transcranial magnetic stimulation, which can be simulated effectively, stimulates out normal induction signal.The myoelectricity stimulation that appropriate mechanical massage is aided with Magnetic Field-Induced has
Help enlivening for neuron and conduction path.
Finally, checking with EMG method module further includes the pick device for myoelectricity (such as surface electromyogram signal), to detect
Neuroelectricity conducting power.Terminate in MEP detection, judge patient there is no spinal cord, the serious damage of nerve etc. be not suitable for it is mechanical by
After the disease rubbed, the electromyography signal of the specific massage part of myoelectricity pick device real-time detection patient.There is pain, convulsion in muscle
When contraction or simple fatigue problem, problem (including pain point, spasm point and tired area etc., the same below) peripheral nerve transmitting fiber tow
It leads speed to slow down, poor blood circulation.It can be confirmed and be made by the detection of electromyography signal and further distinguished in detail.
Recent sports medical science research shows that: human skeletal muscle's slow switch fibers is more, and area percentage is bigger, electromyography signal
MPF descending slope is slower in frequency-domain analysis index.Further, pain especially chronic long pain can lead to local muscle
Fast muscle fiber accounting and volume increase and slow switch fibers is accordingly weakened, and significantly increase so as to cause MPF value descending slope.Example
Such as, clinical discovery teres minor pathological inflammatory or non-pathologic spasm can lead to dorsal root ganglia frequency of spontaneous discharges
Increase, radial pain as a result may be generated at corresponding side root pain and upper limb.Problem --- around painful area
Related neural tissue can have the generation of high frequency electrical signal, be presented as median frequency dramatic decrease namely median frequency slope
(median frequency slope, MPs) increases obvious.Inventor thinks the height occurred during this nerve fibers conduct
The quick interruption phenomenon of frequency, is a kind of adaptive phenomenon of human body under incomplete block.The high frequency intermittent phenomenon of problem electric signal,
So that organ-tissue peripheral cell charge quickly changes between increasing and reducing.
And in the aching pain of muscles that sports fatigue generates, maintain muscle tone to strengthen motor unit when due to fatigue emerging
The synchronism put forth energy;And intramuscular pressure increases the sarolemma surexcitation that caused blood flow is obstructed with lactic acid accumulation generation, to lead
Muscle fiber conduction velocity is caused to reduce (muscle fiber conduction velocity), it can be in this fatigue after exercise
As dominant index.It may be implemented myoelectric amplitude and slowly increased by massage, physical therapy, the frequency of average power of electromyography signal
(median power frequency, MPF) is also raised simultaneously, it is understood that it is rested for fast muscle fiber, lactic acid metabolism
Restore normal with problem blood circulation.
The electrode sample frequency for detecting pain signal is 300Hz-500Hz, preferably 450Hz;Tired signal detection electrode
Setting sample frequency is 8-300Hz, preferably 20-100Hz, more preferably 50Hz.Common-mode rejection ratio is greater than 120dB, sensitivity 1
μV.Pickoff electrode measures fleshy exterior face electrical activity using active surface electrode, and conduction region diameter is between 6-12mm.Electrode selects stone
Electrode ink or Ti electrode, prevent it from accident occurring in magnetic field.
Patient's readme affected part is smeared using skin temperature allochroic paint before placing the electrode of myoelectricity pick device and is prolonged to backbone side
Smearing is stretched, which can effectively identify body surface temp different, influence the position of blood circulation in muscular tone, spasm etc.
It sets and forms sharp contrast with surrounding and strong side.The skin temperature allochroic paint is using palmityl alcohol, myristyl alcohol two kinds of organic matters
Binary mixture is solvent, is allowed to color change interval between substantially 30-44 degrees Celsius with when processing technology by adjusting the two,
Between 33-40 degrees Celsius.Have in above-mentioned smearing allochroic paint region significantly lower than strong side and periphery
The low temperature point at position makes label.
Every group of three electrodes are arranged centered on the mark point, and active, measuring electrode line is parallel at mark point
Main muscle fibre trend, electrode long axis itself and muscle fibre are in the same direction, spacing 2-2.5cm, and avoid being placed on tendon as far as possible, in
Property electrode be placed on above-mentioned mark point nearby voltage-neutral location.Strong side is symmetrically chosen, and one group of electrode is equally arranged.
It is connected with electromyography signal in-situ processing device after electromyography signal pick device, is patrolled after realizing filtering, amplification
Judgement is collected, if the signal obtained in low-frequency sampling timing enters tired signal and judges process;If in high frequency sampling time sequence
The signal inside obtained then enters pain signal and judges process.In above-mentioned electromyography signal judgement process, realize that fast Flourier becomes
Its MPF value is got in return, to carry out frequency-domain analysis.Use whether Matalab analyzer monitoring MPF value meets during frequency-domain analysis
, for example there is rapid decrease in pre-set level or even flash (similar cliff of displacement formula declines) phenomenon then indicates that it enters alleviation mode 2-1,
Otherwise enter relaxed mode 2-2;Adaptive neural network mode of learning can also be used to judge, Binding experiment number of chambers evidence obtains
To natural spine two sides myoelectricity distribution map, add for different heights, age, weight or even Anthropometric parameters setting human region myoelectricity
Weight coefficient table judges after Ipsilateral myoelectricity data/strong side data is more than weighting coefficient.
The working procedure of control module is carried out according to lower row logic during above-mentioned picking up signal: detection transcranial magnetic stimulation
Targeted muscles generate MEP signal, judge neural downlink conductive link with the presence or absence of damage, be embodied in D wave whether by
It is correctly detecting;Then strictly forbid any type of mechanical massage if there is link conductive impairment;If D wave signal normally if
Into real-time table facial muscle pyroelectric monitor process, mainly whether there is rapid decrease or even sudden strain of a muscle by MPF value in monitoring signals among these
Disconnected phenomenon come determine enter which kind of massage mode, can also further combined with MPs signal and monitor electromyography signal latent time.
In alleviating mode 2-1, apply magnetostatic field, (or left and right) direction is arranged above and below massage bed in size 0.6-0.9T;
Backbone side, which is traced back, in skin temperature indicating positions applies ultrasound, the ultrasound convergence depth 0.8-2.5cm, frequency 0.2-1.0MHz, function
Rate 1mW/cm2;Ultrasonic transducer used is close to skin, transducer probe effective area 10mm × 8mm, longitudinally perpendicular in human body ridge
Column direction.Ultrasound corresponds at substantially neuromere the convergent point for forming 1 square centimeter area, nerve fiber at this in subcutaneous tissue
Middle cell wall can be vibrated with intracytoplasmic charged particle, lead to cell membrane depolarization according to Hall effect.Movement electricity
Position will be conducted to corresponding skeletal muscle, cause slightly to twitch or tremble.This action potential is issued by autologous patient neurode, tool
There are altitude simulation and adaptability, induction obtains its size of action potential and supersonic frequency nonlinear correlation.At the same time, aforementioned
Supersonic frequency size makes adaptive change with the electromyography signal that aforementioned pickoff electrode obtains, which makes myoelectricity
MPF drop-out value reduces.Because of " logical or nothing " characteristic of multiple neuron membrane depolarizations, clinically it can be observed that above-mentioned induction
The non-linear increase of current potential namely its be likely to occur do not follow supersonic frequency to adjust and the phenomenon that linear change.Control module pair
The adjusting of supersonic frequency is carried out as unit of 0.1KHz, and the supersonic frequency adjusted every time keeps at least one more than the period, in week
Period is every the above-mentioned MPF value of detection.
In relaxed mode 2-2, apply magnetostatic field (avoiding acting on user head), size 2.5T can massaged
Bed (or left and right) direction setting up and down;Then select temperature change most visibility point as gradient magnetic according to the instruction of above-mentioned skin temperature
Field action band center applies gradient magnetic, size 100mT, switching rate 10-15mT/m.s(y circle).Under its effect, on
It states tissue of the zone of action including nerve, muscle receptors and bioelectrical effect occurs to occur visually imperceptible random
Then belly of muscle is shaken, and facilitates blood circulation and lactic acid metabolism, while generating more or less according to gradient magnetic switching rate difference
Heat.The part that the heat of generation will lead to coating skin temperature allochroic paint occurs temperature and changes, and is reaching phase wherein included
It will lead to phase-change material absorption heat liquefaction after becoming material threshold, to avoid skin thermal damage.Meanwhile operator can pass through
The color of skin temperature allochroic paint monitors skin temperature.In the dwelling period of gradient magnetic, myoelectricity acquisition module is started to work the period
When, above-mentioned phase-change material will also have an effect too low to avoid coated portion temperature, prevent skin, muscle due to cold and hot change
Muscle tonue caused by changing causes electromyography signal error.
Electrocardiogram large sample analysis for different parting cervical spondylosis patients is the result shows that cervical spondylosis and electrocardiographic abnormality
With larger correlation or even identity, therefore the neck heart syndrome that is otherwise known as.In the process for carrying out magnetic stimulation to peripheral nerve
The bioelectricity of middle generation inevitably will partly overlap or even conflict with electrocardiosignal.Clinical data shows such case
Particularly evident in patient with cervical Spondylopathy, the burst error of ultrasonic magnetic field therapeutic effect will significantly increase.If can be further
Ground increases heart real time detection in the above-mentioned magnetic therapy module course of work, it will cuts for ultrasonic magnetic therapy and provides better opportunity and refer to
Show.
Huo Dun (Holden) 2004 research shows that vascular wall in magnetostatic field can in body surface generate a potential difference,
The induction field may influence propagation (the The sensitivity of the heart to static of electrocardio action potential
Magnetic fields[J] Progress in Biophysics & Molecular Biology, 2005,87 (2-3):
289_320.).For the ECG detectings results such as three existing frequently-used leads, five leads, 12 lead, magnetostatic field sense
The influence of potential is answered to be mainly reflected in the deformation of T wave or delay.Magnetostatic field is treated in alleviation mode 2-1 for example of the present invention, because
Magnetic field strength is smaller to be not enough to significantly affect electrocardio generation, but still can see by detection and experimental result comparison
Similar interference of the bad potential difference for therapeutic effect.In order to avoid interference can add reliable ground, filter for electrocardiogram equipment
And metal casing etc..Further, electrocardiosignal can be made to realize the ultrasound in S wave triggering mode 2-1 by circuit.
And during the field variation of relaxed mode 2-2, the detection of electrocardiosignal tends to occur serious distortion, so such as
What realizes that better magnetic therapy incision opportunity would be further desirable to the technical issues of solving.In " the abdomen that Hebei Normal University is carried out
Formula breathe for Heart rate influences " experiment obtained in statistics indicate that it is subjective control abdominal respiration rhythm facilitate control heart rate
In a relatively low and stable level.The correlative study of same Xi'an Communications University also indicates that heart rate and breathing can be accomplished
Interaction, details are not described herein for coupled relation.In the present invention, lower heart rate is bioelectric to peripheral nerve for avoiding
Interference is obvious advantageous;There can be an obvious loosening stage in the end of breath respiratory muscle of abdominal respiration simultaneously, it should
Stage can be reached 6-8 seconds by the conscious extension of user.The gradient magnetic switching rate in 2-2 massaging way is controlled at this time
For peak value, better effect will be obtained.Therefore breathing instruction device is further arranged in the present invention, uses the sound of any prior art
Photoelectricity etc. prompts means, such as buzzer or LED flash decorations.It is used to indicate the frequency that user carries out abdominal respiration,
The variation for cooperating gradient magnetic after user enters steady respiratory state simultaneously, makes exhaling for magnetic field switching frequency and abdominal respiration
The gas stage keeps synchronizing.Clinical trial shows that most of adults can protect when cooperation breathing instruction device carries out abdominal respiration
Hold 5-7 times per minute respiratory rate, while the lower heart rate level that heart rate will drop in its normal range (NR).Combined magnetic field at this time
Therapeutic effect is significantly increased, and in treatment time isometric situation, the MPF value measured opposite can rise 1%-10% and differ.
Again further, increase drug adjuvant treatment effect in the above-mentioned rehabilitation system course of work, by medication mould
Block is realized, it is therefore intended that is promoted local location blood flow, is improved the remission effect of muscular tone.The drug uses this field
Psoralen known to technical staff, promoting blood circulation proved recipe increase and decrease, are mixed into aforementioned after further grinding effective component after boiling purifies
The position for receiving magnetic therapy is coated in skin temperature allochroic paint.Skin is penetrated into after the process said medicine of Neural stem cell is heated to realize
Drug effect.
It is normal in the conduction of D wave, and indirect wave I wave incubation period lengthens that (criterion is substantially on 1.5 times of ordinary duration
When, notice that MEP signal is likely to occur the wave amplitude between single, preclinical variation, control module can be until it be relatively stable
It is calculated and compared) when, it may indicate neurotrosis, for example nerve contusion, de- sheath.Dominant neurotrosis often implies it
The skeletal muscle of domination and corresponding bone damage, wherein being endangered especially with Occult Fracture maximum.Occult Fracture is also referred to as invisible
Fracture is often caused by fatigue, recessive wound etc., is not easy to find and delay the state of an illness under common X-ray, or even causes related mind
The secondary damage of warp.In order to accelerate the healing of fracture especially Occult Fracture, invention proposes providing neural bone fracture Working moulds
Formula 2-3.
Specifically when reaching same gender adult tranquillization, state of flaccid muscles in I wave incubation period 1.5 times of ordinary duration it
When upper, device is transferred to neural bone wound recovering mode 2-3 by control module.Further, in order to improve accuracy, can also continuously into
The Neural stem cell of the same intensity of row.MEP letter such as is generated in the continuous Neural stem cell three times that above-mentioned targeted muscles position electrode obtains at this time
I crest value amplitude (taking peak-to-peak voltage, unit is millivolt) and incubation period in number (are defined as since stimulation to muscle movement electricity
Position occurs, and unit is millisecond) when respectively difference is no more than 20% between any two, by MEP crest value amplitude h1 and the incubation period three times
The data such as t1, which record respectively and respectively do weighted average, obtains crest value mean value of amplitudeh1Witht1.Reason be MEP be easy by
It influences and fluctuates to various factors, for example patient measured place muscle activity, breathing, the influence of heartbeat or even psychological factor be all
It may cause its numerical value to change.
The I crest value amplitude that above-mentioned average value is obtained with strong side corresponding position respectivelyh2And incubation periodt2It compares,
The strong side position obtainsh2Witht2It is equally the average value obtained according to the method described above.The average computation is good for side and Ipsilateral
Comparison and logic analysis gate control logic circuit is programmed by real-time live and is carried out.At this time if comparison result is eligible
One:h1It ish285% or less (include 85%) and eligible two:t1It ist2150% on when, control module is by whole device
It is transferred to neural bone wound recovering operating mode 2-3.Under laboratory conditionh1It ish290% or less can have ready conditions think mark point
It sets and traces back nerve pathway and damage, standard is strictly already allowed for into the factors such as environment and operator to 85%.
In above-mentioned operating mode 2-3, the acusector of skin electrode uses empty micropin (the acusector material and aforementioned class instead
Seemingly, can be used for the commercially available electrode acusector of magnetic field work), set-up mode is the same as aforementioned.Changed colour before placing electrode using skin temperature
Coating material patient's readme affected part simultaneously extends smearing to backbone side, which can effectively identify body surface temp different,
Muscular tone, spasm etc. influence blood circulation position and around and strong side formed sharp contrast.The skin temperature discoloration applies
Material uses the binary mixture of two kinds of palmityl alcohol, myristyl alcohol organic matters for solvent, by adjusting the two with when processing technology
Color change interval is allowed between substantially 30-44 degrees Celsius, between 33-40 degrees Celsius.Change colour in above-mentioned smearing
Have in coatings area and obviously make label different from the point in strong side and peripheral part, both including high temperature dot or including low temperature
Point.Every group of three electrodes are arranged centered on the mark point, and active, measuring electrode line is parallel to main flesh at mark point
Fiber orientation, electrode long axis itself and muscle fibre are in the same direction, spacing 2-2.5cm, and avoid being placed on tendon as far as possible, neutral electrode
It is placed on above-mentioned mark point voltage-neutral location nearby.Strong side is symmetrically chosen, and one group of electrode is equally arranged.
The sampling sample frequency of electrode is similarly 300Hz-500Hz, preferably 450Hz.Common-mode rejection ratio is greater than 120dB,
1 μ V of sensitivity.Pickoff electrode measures fleshy exterior face electrical activity using active surface electrode, and conduction region diameter is between 6-12mm.Electricity
Graphite electrode or Ti electrode are selected in pole, prevent it from accident occurring in magnetic field.
It is connected with electromyography signal in-situ processing device after electromyography signal pick device, is realized after filtering, amplification quick
Fourier transform obtains its MPF value, to carry out frequency-domain analysis.MPF will appear sudden strain of a muscle described in similar alleviation mode 2-1 at this time
It is disconnected, and performance is more fierce, repeatedly occurs continuous multiple flash and blackout in practice.
Content in above-mentioned empty micropin is the magnetic nano particle bulbec mixture with magnetic compliance.Its in mixture
One using ferroso-ferric oxide as magnetic core, biodegradable organic material, such as the magnetic lipid object that Lopera is used is coated, wherein wrapping
The active drug ingredient contained is that bone morphogenic protein BMP-2 2(uses commercially available recombinant human bone morphogenesis protein freeze-dried powder),
Its three is collectively referred to as osteogenin in the present invention by Osteoprotegerin and prostaglandin PGe2, and preparation process is the prior art;
Secondly being the thermosensitive magnetism nanoparticle bulbec of temperature-responsive, the particle is by magnetic ferroferric oxide nano-particles and is wrapped in magnetic
Property nanoparticle outside a strata N-isopropylacrylamide shell composition, drug wherein included be NF-κappa B receptor activation
The ligand RANKL and insulin-like growth factor 1 of factor R ANK, is collectively referred to as osteoclastic element for the two in the present invention.Research shows that OPG
It is similar with RANKL structure and occupy-place, it can be by competing the combination to successfully inhibit RANKL and its receptor, and then inhibit osteoclastic
The activity of cell, promotes skeletonization indirectly;And prostaglandin PGe2 concentration it is lower or with glucocorticoid (such as cortisone) close
Used time can promote bone cell differentiation and ostosis, and concentration it is higher or with insulin-like growth factor 1(insulin like
Growth factor, IGF) will stimulate when sharing bone resorption and bone metabolism generation (Nakamura H,
etal.Localization of OPG on the bone surface and cement lines in rat
Tibia.Histochen Cyto-chem, 2,002 50 (7): 945-953).Above-mentioned empty micropin tail end is connected by infusion tube
Pressurizing valve constitutes drug infusion system, is managed by control module.
Above-mentioned low temperature and high-temperature discoloration region are set to targeting field, it is fixed to realize by the way of additional magnetic field of permanent magnet
To administration, magnetic induction intensity 0.5-0.9T, the time is greater than 30 minutes.Permanent magnet, control module control are removed after 30 minutes
Drug infusion system processed is to discharge magnetic nano particle bulbec mixture.At this point, control module management breathes instruction device to prompt
Patient carries out high frequency shallow breathing, per minute on 15 times, to achieve the effect that simulate hyperventilation, it may be necessary to be patient
Oxygen supply in short-term is provided.In the fluid environment of similar weak base poisoning, the BMP2 and OPG released plays optimal efficacy
(experimental result has confirmed that the mechanism of action need further to further investigate), promote corresponding position nerve, angiogenic growth and
The healing of the especially recessive bone fracture of bone fracture.
It is worth noting that BMP2 and angiosteosis especially arteries calcification close relation, it is both domestic and external experiments have shown that
It also has certain causality with ectopic ossification (being called ectopic osteogenesis HO, Heterotopic osteogenesis).HO is normal
Often occur for example around hip joint, elbow joint, lumbar vertebrae, cervical vertebra etc., to occur between flesh in large joint.HO cause joint it is limited,
Pain, affected part skin temperature is significantly raised, may be related to affected area blood flow anomalies and stroma cell differentiation;Clinical observation simultaneously shows
Craniocerebral injury merges limbs fracture patient blood flow near lesion and comparatively fast locates multiple early stage HO symptom, and skin equally occurs in similar position
Temperature abnormality increases phenomenon, can substantially demarcate easily hair HO range in conjunction with biological electro-detection.Table is tested according to Jilin Zhong friendship ties hospital
Bright includes: conversion the reason of craniocerebral trauma merges in limbs fracture agglutination, and the disease incidence that HO occurs for patient obviously increases
The raising of growth factor TGF, a large amount of mature and osteoclasts of BMP2 are broken up suppressed etc..The present invention is in order to avoid similar dystopy
Skeletonization and undesirable angiosteosis occur, and the thermosensitive magnetism particle ball comprising osteoclastic element is mixed with inside empty micropin, works as temperature
When degree rises to close to 40 degree, disintegration takes place in the polyisopropyl acrylamide shell of outer cladding, and drug release enters tissue
Gap and by subcutaneously entering blood.The raising of the temperature mainly realized by bone fracture module 7, specifically: if bone fracture module includes
Dry set interference electric current electrode and interference electric current machine.The every set of electrode may include tetrad electrode (the tetrad electrode of commercially available passage
Interference position be located under itself geometric center center) or general electrode (interference position of general electrode is located at two arrays of electrodes
Intersect under line point), it is selected according to site area is implemented;Electrode is set in the High temperature calibration position of Pi Wen discoloration, is handed over
About 2-5 centimetres of depth of fork is specifically chosen depending on four limbs or trunk different location;Using electric current of intermediate frequency, it is specifically chosen 4.5kHz electricity
Stream generates difference frequency 10Hz, the interference electric current of 9-22mA in interference position.The electric current except promote near affected part blood vessel dilatation,
Except lymphatic return and local heating, the fixed point release of osteoclastic element in thermosensitive magnetism particle ball is additionally aided.Passing through Pi Wenbian
The high temperature location of color paint mark nearby release osteogenin and osteoclastic element in blood and tissue fluid because Ligand Competition effect and
The synergy etc. of PGe2 and IGF1 avoids affected area ectopic ossification and intravascular calcification;And it is damaged there may be neural with bone
The position of wound promotes osteoblast differentiation and effect.
Above-mentioned interference electric current machine separately draws multichannel interference circuit, is used to interfere specific sympathetic ganglion, such as starlike mind
Warp knuckle, thoracic ganglia, lumbar ganglia, sacral ganglia etc..The interference electrode setting mode is the same, using ordinary electrode, ability
Field technique personnel know ganglionic normal physiological position and approximate depth, and interference electric current difference frequency is arranged in 100Hz or so, intensity
10mA.It is more for the research of stellate ganglion at this stage, by being injected into planetary ganglionoplegic to carry out a variety of nerves
The treatment of class illness has been that numerous medical personnels are known.But the operation have certain risk, also have for operator compared with
Strong technical requirements.Inventor and this school multiple cooperations department experiments have shown that interfering ganglionic mode to remove mould using interference electric current
Quasi- similar denervation state can although cannot achieve the effect that injecting blocking nerves section and operation loses sympathetic nerve and dominate
Nondestructively to simulate the decrease state that maincenter controls sympathetic nerve in cranial injury as far as possible.And the state that above-mentioned control weakens
For knitting and revascularization have positive effect obtained clinical test confirm (Yasuhara T, Shingo T,
Date I. The potential role of vascular endothelial growth factor in the
central nervoussystem[J]. Rev Neurosci 2004;15 (4): 293-307.).In above-mentioned simulation denervation
Under state, neurotrophic factor in bone tissue target cell function and effect and poroma collagen expression be significantly improved.
Research at this stage thinks that the mechanism of action is part catecholamine and adrenergic high expression and cartilage cell activity at bone injury
Increase etc..
It is above-mentioned that ganglionic interference can selectively interfere injury region domination and ascending nerve, shield
It covers, to induce cranium brain to reflect, to realize: on the one hand directly improving nerve, muscle and the skeletal tissue's inner cell of injury region
The liveness and binding ability of receptor targeted simultaneously increase injury region cartilage cell activity, simulate denervation state on the other hand to lure
Cranium brain secretion is led more from source nerve growth factor and calcitonin gene peptide etc., is eager to excel for the facilitation of knitting
In present current injection mouse nerve growth factor.
Specific embodiment
Spine recovering system includes the physical therapy rack 31 as carrying user, which is equipped with corresponding to number of people face
Opening breathes convenient for user's prostrate.Rack uses non-metallic material, avoids influencing electromagnetic curing therapeutic effect, and lower section is equipped with four
The support post of band idler wheel.It is equipped with cyclic annular fence 32 around the rack 31, there is activity in corresponding user foot fence
Railing, whole fence are in the openable and closable shape of the mouth as one speaks in one end.It is equipped with support arm 321 in the corresponding user's head position of fence 32, is being enclosed
Column side corresponds to the support arm 322 that user's trunk is equipped with more or more.The support arm can be with multi-angle rotary, bending simultaneously
And it can slide on fence to adapt to different location.Support arm material is using nonmetallic, and its end is equipped with fixing seat 323.
Be detachably connected in the fixing seat of above-mentioned support arm ultrasonic probe, infrared probe, gradient magnetic field coil, permanent magnet and
Electrode etc..It is equipped with magnetostatic field generator 324 on the left of fence, is provided in fact referring now to user's metastomium on rack 31 quiet
Magnetic field.Size is specially 0.6-0.9T, is realized by steady controllable current, and the various common techniques in this field can be used.Make in correspondence
It is equipped with magnetic shield panel 325 at the fence of user's head position, uses the ferromagnetic material that magnetic conductivity is high, such as be made can edge for silicon steel
The barricade of fence slidable adjustment, thickness is between 1-5mm.Slide into foldable lid behind appropriate location be overlying on user head with
User head is effectively avoided to receive unnecessary magnetic stimulation.
It is removably fixed with plate circle or splayed coil 21 in the fixing seat of above-mentioned support arm 321, can be iron
Wire-core coil or built-up coil.Coil diameter is between 9-20cm, preferably 12-15cm, and the peak magnetic field of generation is not less than 1T.It is passing through
Hub of a spool is made to be less than 3.5cm away from user crown distance by adjusting support arm during cranium Neural stem cell.Changing currents with time produces
Raw field frequency is greater than 1Hz, and the winding wire is connected to control module by the fixing seat on support arm 321.?
Anode electrode 11 is arranged in the transcranial magnetic stimulation stage at user back or four limbs targeted muscles belly of muscle, is dominating the targeted muscles
Neural downlink close at tendon setting cathode electrode 12.Electrode uses graphite electrode, between the two away from 35mm or more.Selected
Muscle includes but is not limited to deltoid muscle, the bicipital muscle of arm, the triceps muscle of arm, biceps muscle of thigh etc., even can using smaller electrode
To monitor the current conditions of hand fine muscle.One transcranial magnetic stimulation period can be manually set by control module, generally
Between 120s-600s.The above-mentioned collected signal of two electrodes is sent to control module, is analyzed after filter shape amplifies
As follows: 1, control module carries out warning note in the case of retardance occurs in the receive first single-phase positive D wave, reminds operator
The user not can be carried out any type of mechanical massage and stop further transcranial magnetic stimulation and carries out;2, when D wave conducts just
Often, automatically into operating mode 2-1 or 2-2 when and I wave incubation period does not reach 1.5 times of ordinary duration;3, when D wave conducts just
Often, indirect wave I wave incubation period when being lengthened on 1.5 times of ordinary duration, control module control whole device enters Working mould
Formula 2-3.
After entering any of the above-described operating mode, control module stops continuing for transcranial magnetic stimulation, then drives flesh
The pickup of the progress surface electromyogram signal of electro-detection module 1.The take-off location of surface electromyogram signal is mark point, the mark point
Selection can be further accurately positioned using skin temperature allochroic paint according to user's readme.Specific practice are as follows: choose palm fibre
Palmitic acid alcohol, myristyl alcohol, procrypsis agent and color developing agent are raw material, and wherein procrypsis agent can choose heat sensitive dye crystal violet lactone CVL, colour developing
Diphenol propane BPA is chosen in agent, and two kinds of alcohol exist as solvent and proportion object.Solvent and solute are poured into the container of heating water bath
Middle stirring obtains compound in enough one hour.Its discoloration depends on the mass ratio of four kinds of substances, works as CVL:BPA: nutmeg
Alcohol: for the mass ratio of palmityl alcohol in 1:3.3:41:22, compound fusing point is minimum, and has well between 33-40 degrees Celsius
Discoloration.Above-mentioned compound is uniformly mixed with common phase-change material, phase-change material can choose paraffin etc., by simple
Proportion is processed so that its phase transition temperature is at 40 degree or so.Mixed phase-change material and above-mentioned compound are coated on user's readme
Affected part and strong side corresponding position.Observation is whether there is or not obvious skin temperature metachromatism after parked 3 minutes, with surrounding skin significant difference
Or it is marked with the visibly different position in strong side.
Surface electromyogram signal pickoff electrode is set centered on mark point, and one group of three electrode 13 wherein put by neutral electrode
It sets in the voltage-neutral location nearest away from mark point, active measuring electrode then guarantees that its line is parallel to main muscle fibre at mark point
Trend;Electrode long axis itself and main muscle fibre are in the same direction, two electrodes at a distance of 2-2.5cm, try not to be placed at this time tendon it
On.In the same symmetrically placed one group of electrode 14 in strong side.The electrode sample frequency for detecting pain signal is 300Hz-500Hz, preferably
For 450Hz;Tired signal detection electrode setting sample frequency is 8-300Hz, preferably 20-100Hz, more preferably 50Hz.Altogether
Mould inhibits than being greater than 120dB, 1 μ V of sensitivity.Pickoff electrode measures fleshy exterior face electrical activity using active surface electrode, and conduction region is straight
Diameter is between 6-12mm.Electrode selects graphite electrode or Ti electrode.Electrode sample frequency and detection pain in operating mode 2-3
Signal it is identical.
It is illustrated by taking a mark point as an example below: the two arrays of electrodes being arranged from the Ipsilateral mark point and corresponding strong side
The conducting wire of extraction realizes that Fast Fourier Transform obtains its MPF value after passing through filter and amplification respectively.Thereafter two groups of data respectively into
Enter the logic judgment unit 41 of control module.The Ipsilateral signal obtained in high frequency sampling time sequence enter pain signal judge into
Journey, and the Ipsilateral signal obtained in low-frequency sampling timing enters low frequency and judges process.The control module in each judgement process
Matalab analyzer 42 carries out frequency-domain analysis to it, first determines whether that MPF value obtained in high frequency sampling time sequence is quick whether there is or not occurring
Decline or flash phenomenon, judgment criteria are to measure the corresponding median frequency slope (MPs) whether there is or not apparent increase, and slope value is normal
Range induction signal should be made with reference to user's age, body fat, weight and strong side it is default, can also be by repeatedly real to user
It tests and carries out adaptive learning acquisition.The general MPs value is more than or equal to 60% i.e. it is believed that the affected part muscle of user is managed
It treats and alleviates, into process 2-1.If there is not the case where above-mentioned rapid decrease in MPF value obtained in high frequency sampling time sequence, point
The MPF value that further analysis affected part low-frequency sampling obtains of analyzer 42, and analysis comparison is carried out also according to above-mentioned steps.At this time
MPs value is greater than 45% and the latent time of collected electromyography signal is combined to may determine that user needs to carry out physical therapy and loosens, into
Enter process 2-2.
In mode 2-1, control module starts magnetostatic field generator 324 and applies magnetostatic field, and size 0.6-0.9T's is magnetostatic
Field is applied at user's trunk, especially backbone;Setting region of insonation at the 5-10cm of backbone side is traced back in mark point;It is logical
It crosses ultrasonic probe and applies ultrasound, ultrasound convergence the depth 0.8-2.5cm, frequency 0.3-1.0MHz, power 1mW/cm2;It is used
The energy converter of ultrasonic probe is close to skin, energy converter effective area 10mm × 8mm, longitudinally perpendicular in human spine direction.Ultrasound
Correspond to the convergent point that 1 square centimeter area is formed substantially at neuromere in subcutaneous tissue, at this in nerve fiber cell wall with
Intracytoplasmic charged particle can vibrate, and lead to cell membrane depolarization according to Hall effect.Action potential will conduct
To corresponding skeletal muscle, cause slightly to twitch or tremble.At the same time, supersonic frequency and intensity are with aforementioned surfaces myoelectricity pickoff electrode
Obtained electromyography signal makes adaptability adjusting, which makes the MPF drop-out value of myoelectricity reduce or in other words make MPs
It is worth " raising ".Every work a cycle control module stops magnetic field function, into surface electromyogram signal acquisition timing.Operating mode
Enter high frequency sampling time sequence after 2-1, the skin surface electromyography signal of pickup repeats the above steps again.Until the MPF measured
Or MPs value reaches preset standard or reaches the predetermined time.
In mode 2-2, apply magnetostatic field (avoiding acting on user head), size 2.5T can be on a massage bed left side
Right direction setting;Then select temperature change most visibility point as in Actions of Gradient Magnetic Field band according to the instruction of above-mentioned skin temperature
The heart applies gradient fields, size 100mT, switching rate 10-15mT/m.s(y circle).Gradient coil setting aforementioned support arm it
On one.
Under the Actions of Gradient Magnetic Field, bioelectricity occurs for tissue of the above-mentioned zone of action including nerve, muscle receptors
Effect to by naked eyes it is imperceptible it is random in the form of realize belly of muscle shake.Clinical trial show this promoting blood circulation and
It additionally aids the fatigue recovery of corresponding nerve pathway after lactic acid metabolism, while generating according to gradient magnetic switching rate difference or more
Or few heat.The part that the heat of generation will lead to coating skin temperature allochroic paint occurs temperature and changes, and wherein includes reaching
Phase-change material threshold value after will lead to phase-change material absorb heat liquefaction, to avoid skin thermal damage.Meanwhile operator can be with
Skin temperature is monitored by the color of skin temperature allochroic paint.In the dwelling period of gradient magnetic, myoelectricity acquisition module is started to work
When the period, above-mentioned phase-change material will also undergo phase transition release heat it is too low to avoid coated portion temperature, prevent skin, flesh
Meat muscle tonue as caused by cold and hot variation causes electromyography signal error.Gradient magnetic switching rate size is obtained with aforementioned pickoff electrode
To electromyography signal make adaptive change, which makes the MPF drop-out value of myoelectricity reduce or in other words make MPs value
" raising ".Every work a cycle control module stops magnetic field function, into surface electromyogram signal acquisition timing.The difference is that work
Enter low-frequency sampling timing after operation mode 2-2, the signal of pickup repeats the above steps again, until MPF or MPs value reaches pre-
Bidding is quasi-.
Wherein the gradient magnetic field coil is by being arranged figure-eight coil on aforementioned support arm holders, the coil upper half
A 0 is fixed in fixing seat, and lower half of O is arranged below aforementioned rack.Upper lower coil is opposite to be constituted, and entire coil can follow
Support arm is moved forward and backward to adapt to the variation of different location.
Infrared skin temperature monitoring probe can further be added to prevent scald.The infrared radiation thermometer uses
This field common technique can be realized, and monitoring range is between 30-45 degrees Celsius.It is solid that its detecting head is mounted on aforementioned support arm
In reservation, it is electrically connected with control module.By presetting early warning temperature in control module, such as 41 degrees Celsius (need to consider herein
The specific selection of phase-change material), to realize the temperature pre-warning for monitoring area, prevent scald or unexpected generation.
Further in order to avoid in mode 2-1 magnetostatic field generate the mutual of electric potential field and electrocardio action potential in vascular wall
It influences, it can be using introducing electrocardioscanner 61.It, which uses the modes such as three common leads, five leads or 12 lead to detect, makes
User's electrocardio.In order to avoid interference using the modes such as reliable ground, filter and outer cover metal-coating to electrocardioscanner 61 into
Row protection.The starting of electrocardio S wave triggering ultrasound can also be realized using detection trigger circuit.Namely increase on electrocardioscanner
If related circuit: ECG signal sampling circuit 62 realizes the amplification to electrocardiosignal, and signal band can in 1-2KHz, amplification factor
With adjustment;S wave detecting circuit 63 is made of follower, QRS filter, whole wave circuit, peak-holding circuit and comparator.Electrocardio
Figure output signal, which is converted to be input in monostable flipflop after the whole wave of voltage signal, detects S wave, and obtains S wave lock-out pulse
Signal.Driving circuit is triggered in the rising edge of S wave, realizes the starting for ultrasonic signal.Evaded out based on the trigger circuit
The R wave of heart action potential acts on, to reduce influencing each other for the two.Further, trigger circuit is not direct and starts
Circuit is connected and is connect by control module with start-up circuit.At this time after obtaining rising edge trigger signal, control module should
Signal is temporary, just starts ultrasonic signal after obtaining next trigger signal;Above-mentioned temporary behavior can effectively reduce periphery mind
The refractory period of warp is reacted, and treatment effective time is increased.It can also be further arranged according to actual effect and keep in two or more triggerings
Just awaiting a favorable opportunity after signal drives ultrasound circuitry to work.
Further in order to realize better magnetic therapy incision opportunity problem in mode 2-2.In fence close to user
Head position adds a buzzer or similar warning means.The buzzer is electrically connected control module and by its management, for instructing
User carries out the frequency of abdominal respiration, while cooperating the variation of gradient magnetic after user enters steady respiratory state, makes
Magnetic field switching frequency is synchronous with the holding of the expiration phase of abdominal respiration.Specifically buzzer, which sounds, prompts user's air-breathing, control
Molding block sounds in buzzer to be controlled the switching rate of gradient magnetic field coil between 3s-6s and is at least held on the 80% of its peak value.
Clinical trial shows that most of adults are able to maintain 5-7 times per minute when cooperation breathing instruction device carries out abdominal respiration
Respiratory rate, while the lower heart rate level that heart rate will drop in its normal range (NR).Combined magnetic field therapeutic effect has significantly at this time
It improves, in treatment time isometric situation, the MPF value measured opposite can rise 1%-10% and differ.
Again further, increase drug adjuvant treatment effect in the above-mentioned rehabilitation system course of work, by medication mould
Block is realized, it is therefore intended that is promoted local location blood flow, is improved the remission effect of muscular tone.The drug uses this field
Psoralen known to technical staff, promoting blood circulation proved recipe increase and decrease, are mixed into aforementioned after further grinding effective component after boiling purifies
The position for receiving magnetic therapy is coated in skin temperature allochroic paint.Skin is penetrated into after the process said medicine of Neural stem cell is heated to realize
Drug effect.Specific drug component is following (mass ratio): Herba Epimedii 5, the rhizome of davallia 21, radix achyranthis bidentatae 6, safflower 1, radix saposhnikoviae 9, Moschus 1, mountain paint 2,
Dragon's blood 11, psoralea corylifolia 3, amber 4, Rhizoma Chuanxiong 10, Rhizoma Et Radix Notopterygii 2.The drug ingedient can also be individually coated with after removing skin temperature allochroic paint
In affected part, temperature monitoring is completed by aforementioned infrared probe completely at this time.Aerogel dressing cooperation can also be added in use process;?
Even spread said medicine coating in medical aseptic transparent aquagel dressing layer;Cutting out dressing layer is specific shape, is laid in ridge
Column two sides main muscle group, such as erector spinae, multifidus etc. are not limited to specific magnetic therapy position;Need cooperation corresponding after coating simultaneously
The mechanical stretch effect of muscle group is realized by adding upper limb mechanical stretch bar;The stayed pole is set to massage platform user
Head side, height are slightly above the user back of prostrate;Direction of draw is parallel to the platform, and force direction is far from human body
To realize the drawing to user's upper limb;Drawing is controlled by control module, and frequency is between 5-15 times per minute.Further
, drawing can be matched with abdominal respiration frequency.Specifically, buzzer sound prompt user breathe after pull, lead
Pull and support it is 4-8 seconds continuous after loosen;User is disappeared using traction force to be indicated as exhaling.
In neural bone wound recovering operating mode 2-3, physical therapy rack 31 is lower to accommodate interference electric current machine 71, is connected by conducting wire
Connect multiple interference electrodes 711;The interference electrode 711 can be arranged on support arm 322, the mind different with correspondence easy to remove
Warp knuckle;Pressurizing valve 72 is also accommodated under physical therapy rack, and multiple empty micropin electrodes 722 are connected as table by infusion tube 721
Facial muscle electric signal pickoff electrode;One group three, the empty micropin electrode, neutral electrode therein is placed on nearest away from mark point
Voltage-neutral location, two active measuring electrodes then guarantee that its line is parallel to main muscle fibre trend at mark point;Electrode itself
Long axis and main muscle fibre are in the same direction, and two active electrodes are at a distance of 2-2.5cm.In the same symmetrically placed one group of empty micropin electricity in strong side
Pole.Sample frequency is 300Hz-500Hz, preferably 450Hz, and common-mode rejection ratio is greater than 120dB, 1 μ V of sensitivity.Pickoff electrode is adopted
Fleshy exterior face electrical activity is measured with active surface electrode, conduction region diameter is between 6-10mm.Electrode selects graphite electrode or titanium electricity
Pole.
Further, above-mentioned empty micropin tail end connects pressurizing valve structure by infusion tube and realizes that drug is controllably transfused, and is good for side
Without infusion of drug.Include the magnetic nano particle bulbec mixture with magnetic compliance in pressurizing valve and micropin.In mixture
One coats biodegradable organic material, such as the magnetic lipid object that Lopera is used using ferroso-ferric oxide as magnetic core, wherein
The active drug ingredient for including be bone morphogenic protein BMP-2 2(use commercially available recombinant human bone morphogenesis protein freeze-dried powder), bone
Protect element OPG and prostaglandin PGe2, it is of the invention in its three is collectively referred to as osteogenin, preparation process is the prior art;Its
Two be the thermosensitive magnetism nanoparticle bulbec of temperature-responsive, and the particle is by magnetic ferroferric oxide nano-particles and is wrapped in magnetism
Outside nanoparticle a strata N-isopropylacrylamide shell composition, drug wherein included be NF-κappa B receptor activation because
The ligand RANKL and insulin-like growth factor 1 of sub- RANK claims the two to be collectively referred to as osteoclastic element in the present invention.By above-mentioned mark point
Region is set as targeting field, and the magnetic field setting of mark point, magnetic induction intensity 0.5- are realized by the way of additional permanent magnet
0.9T, time are greater than 30 minutes.The permanent magnet is selected as state of the art, and unipolarity is cylindrical, section radius of circle
1.5-4cm.It is arranged on support arm 322, is located in above mark point at 3-8cm by adjustable support arm.The permanent magnet
326 not only provide targeting magnetic field environment, and the prior art also shows that it is conducive to the healing of recessive bone fracture.Apply targeting magnetic field in
After mark point 30 minutes, control module controls infusion of drug to discharge magnetic nano particle bulbec mixture.At this point, control module pipe
The breathing instruction device prompt patient of reason carries out high frequency shallow breathing, per minute on 15 times, to reach simulation hyperventilation
Effect, it may be necessary to provide oxygen supply in short-term for patient.Indicating mode can equally be adornd using buzzer or LED flash
Deng.
While patient is breathed in accordance with the instructions, control module controls bone fracture module 7 and runs.The bone fracture module includes
Interference electric current electrode and interference electric current machine;The electrode includes the tetrad electrode (interference position of tetrad electrode of commercially available passage
Under center) or general electrode (interference position of general electrode is located at two arrays of electrodes and intersects under line point), root
Site area is factually applied to be selected;It is aforementioned from spatially avoiding as far as possible in the High temperature calibration location position electrode of Pi Wen discoloration
Surface electromyogram signal pickoff electrode, is specifically chosen depending on four limbs or trunk different location by about 2-5 centimetres of interleaving depth;In use
Frequency electric current, specially 4.5kHz electric current generate difference frequency 10Hz, the interference electric current of 9-22mA in interference position.The electric current removes
Affected part nearby promotes except blood vessel dilatation, lymphatic return and local heating, additionally aids osteoclastic element in thermosensitive magnetism particle ball
Fixed point release.When temperature rises to close to 40 degree, disintegration, drug takes place in the polyisopropyl acrylamide shell of outer cladding
Discharge into tissue space and by subcutaneously entering blood.Because Ligand Competition effect and synergy of PGe2 and IGF1 etc. avoid
Affected area ectopic ossification and intravascular calcification;And there may be nerve and bone injury position promote osteoblast differentiation and
Effect.And at the time of reaching close to 40 degree, phase transformation takes place in skin temperature allochroic paint, avoids temperature excessively high and osteoclastic element
Excessively release.
Above-mentioned interference electric current machine separately draws multichannel interference circuit, is used to interfere specific sympathetic ganglion, such as but unlimited
In stellate ganglion, thoracic ganglia, lumbar ganglia, sacral ganglia etc..The interference electrode setting mode is the same, using common electricity
Pole, electrode connecting line intersect, and crosspoint corresponds to neuromere position, its known appropriate depth of those skilled in the art.Electric current of intermediate frequency exists
The interference electric current difference frequency that interference position generates is in 100Hz or so, intensity 10mA.Interference electric current inhibits corresponding ganglionic emerging
It puts forth energy, plays the effect of similar ganglionoplegic, the activity of osteoclastic element and osteogenin can be effectively facilitated.When retardance to effectively nerve
When section, will obviously it rise in the MPF signal that the electromyographic electrode of high temperature mark point obtains, ascensional range generally can achieve initial survey
12% or more of the MPF value of amount, this is also that effectively ganglionic method is defined in the present invention.So-called effective neuromere is in the present invention
In may include muscle where mark point dominating neural neuromere, such as direct dominating neural section and it is that may be present in
Other neuromeres on pivot to the direct dominating neural section path.Fast and accurately ganglionic trunk is carried out for different target muscle
Interference resistance is stagnant to need operator to have rich experiences and anatomical knowledge;Simultaneously as the complexity and vulnerability to jamming of nervous system,
Effective neuromere may occur blockage effect and degenerate due to stimulation oversaturation or patient muscle's anxiety, also referred to as ganglionic easyization.
The present invention is based on this to devise a kind of rotation neuromere conflicting mode, (the n mono- for having preset n ganglionic interference electrodes
As value between 3 and 6, excessive interference electrode be easy to cause interference period total duration too long, influences eventual rehabilitation effect):
Preset n neuromere interference electrode is taken turns starting in each period of 1 to n-th interference period;And it is interfered at (n+1)th
Only start effectively ganglionic interference electrode (possible more than one) in period;N-th+2 to the 2n+1 each period in period
Inside successively take turns starting preset n neuromere interference electrode;And so on, terminate to preset time.In each ganglionic trunk
CP crypto period is inserted into an electromyography signal pick-up time period after terminating, at electromyography signal pick-up time period end according to the raising of MPF
Amplitude determines whether for effective ganglionic interference electrode.If an effective neuromere all cannot be true in a round
It is fixed, then will not interfere any neuromere in effective ganglionic trunk CP crypto period of the round, prevent excessive easyization.It is described
The beginning of interference period is subject at the time of remove permanent magnet, and the general total duration that sets is no more than 30 minutes.If necessary, 30
It can apply permanent magnet 30 minutes at mark point again after minute, and be arranged when interference period a length of 30 minutes, as next
Circulation.Above-mentioned interference electric current machine can control affected part interference electrode to work asynchronously with neuromere interference electrode, be released with reaching in affected part
Put the synchronization of osteogenin, osteoclastic element and denervation state.
Because of the characteristic of occult bone fracture, clinically patient is often without typical injury symptoms, but shows as part
Muscle tonue, spasm, and patient cannot usually known at the first time.It is different with the rehabilitation of typical bone injury, it is invisible
Fracture especially oldness Latent fracture patient often has existed a large amount of poroma and fibrous scar in affected part, in some instances it may even be possible to
Amyotrophia.Because muscle feeds back nerve conduction insufficient, the neuromere often over-discharge of affected part muscle is dominated.At this time
Bone cannot be facilitated simply, and affected part blood circulation should be promoted first, improve muscle tone, restore the normal bioelectricity water in affected part
Gentle physiological environment, while giving the note of neuromere necessity interference and affected part magnetic nano particle bulbec mixture of over-discharge
Enter.So further, the present invention is after previous operating modes 2-3 is executed and completed a cycle duration, control module secondary control again
Whole system processed enters a new wheel working cycles: execute transcranial magnetic stimulation, checking with EMG method module to Motion Evoked Potential MEP and
Surface electromyogram signal is detected.
The ordinary duration when the I wave delay that epicycle induces does not reach same gender adult tranquillization, state of flaccid muscles
1.2 times on when, without judging whether MPF value rapid decrease or flash occurs, be directly entered following operating mode: in the work
Work time-histories is set in operation mode to be no less than 30 minutes and guide patient's abdominal respiration by breathing instruction device whole process;Control mould
Block starts magnetostatic field generator 324 and applies magnetostatic field, and the magnetostatic field of size 0.6-0.9T is applied to user's trunk;In mark point
Trace back setting region of insonation at the 5-10cm of backbone side;Control module controls ultrasonic probe and applies ultrasound, the ultrasound convergence
Depth 0.8-2.5cm, frequency 0.3-1.0MHz, power 1mW/cm2;The energy converter of ultrasonic probe used is close to skin, energy converter
Effective area 10mm × 8mm, it is longitudinally perpendicular in human spine direction;Supersonic frequency and intensity are with aforementioned surfaces myoelectricity pickoff electrode
Obtained electromyography signal makes adaptability adjusting, which makes the MPF drop-out value of myoelectricity reduce or in other words make MPs
It is worth " raising ";Control module controls interference electric current machine starting neuromere interference electrode to multiple specific ganglionic interference simultaneously,
Pressurizing valve conveys magnetic nano particle bulbec mixture to empty micropin electrode while interference;It equally can be with to ganglionic interference
Selection rotation neuromere conflicting mode, it is ganglionic to choose including but not limited to starlike, chest, waist, sacral ganglia etc..For the ease of
Narration, is named as occult bone fracture rehabilitation modality 2-4 for the above operating mode.
Further, in occult bone fracture rehabilitation modality 2-4, using further in order to avoid magnetostatic field is in vascular wall
Generation electric potential field influences each other with electrocardio action potential, using electrocardioscanner 61.It uses three common leads, five leads
Or the modes such as 12 lead detect user's electrocardio.In order to avoid interference uses reliable ground, filter and outer cover metal-coating
Etc. modes electrocardioscanner 61 is protected.Opening for electrocardio S wave triggering ultrasound can also be realized using detection trigger circuit
It is dynamic.Namely related circuit is added on electrocardioscanner: ECG signal sampling circuit 62 realizes the amplification to electrocardiosignal, signal
For frequency band in 1-2KHz, amplification factor is adjustable;S wave detecting circuit 63 is protected by follower, QRS filter, whole wave circuit, peak value
Holder and comparator are constituted.Electrocardiogram output signal is converted to be input in monostable flipflop after the whole wave of voltage signal and be detected
S wave out, and obtain S wave synchronization pulse.Driving circuit is triggered in the rising edge of S wave, realizes opening for ultrasonic signal
It is dynamic.The R wave effect for evading out heart action potential based on the trigger circuit, to reduce influencing each other for the two.Further
, trigger circuit is not direct connected with start-up circuit and is connect by control module with start-up circuit.Obtaining rising edge at this time
After trigger signal, control module keeps in the signal, just starts ultrasonic signal after obtaining next trigger signal;It is above-mentioned temporary
Behavior can effectively reduce the refractory period reaction of peripheral nerve, increase treatment effective time.It can also be further according to actual effect
Being arranged just to await a favorable opportunity after keeping in two or more trigger signals drives ultrasound circuitry to work.
Infrared skin temperature monitoring probe can further be added to prevent scald.The infrared radiation thermometer uses
This field common technique can be realized, and monitoring range is between 30-45 degrees Celsius.It is solid that its detecting head is mounted on aforementioned support arm
In reservation, it is electrically connected with control module.By presetting early warning temperature in control module, such as 41 degrees Celsius (need to consider herein
The specific selection of phase-change material), to realize the temperature pre-warning for monitoring area, prevent scald or unexpected generation.
The common single-chip microcontroller in this field can be used in aforementioned control module, field-programmable gate circuit or microcomputer etc. are realized,
With the use of keypad or conventional keypad as input unit.
Above-described embodiment is used as just technical solution of the present invention explanation, should not understand that it protects model as limiting
It encloses.Those skilled in the art on the basis of the present invention done any improvement for not departing from present inventive concept or remodeling without departure from this
Invention protection scope.
Claims (3)
1. the device in spine recovering system for neuromere interference, the spine recovering system include:
Checking with EMG method module 1, magnetic therapy module 2, massage module 3, control module 4, display module 5, ECG module 6 and bone fracture mould
Block 7 etc.;The wherein checking with EMG method module real-time detection human body surface myoelectric, and classified according to myoelectricity level and feature;
The judgement of classification results that the control module is sent according to checking with EMG method module enter it is default alleviate massage mode 2-1, loosen by
Mode of rubbing 2-2 or neural bone wound recovering mode 2-3;In neural bone wound recovering mode 2-3, using the magnetism with magnetic compliance
Nanoparticle bulbec mixture, it includes osteogenins and osteoclastic element;The magnetic nano particle bulbec mixture is placed in pressurizing valve, is added
Pressure valve is connected with the micropin tail end of empty micropin electrode, is managed by control module;Add permanent magnet 30 minutes or more outside the venue in targeting
Afterwards, pressurization injection magnetic nano particle bulbec mixture;Then control module management breathing instruction device prompt patient carries out high frequency
Shallow breathing reaches 15 times per minute or more;
It is characterized by: including that several sets interfere electrode in bone fracture module 7, in the same of injection magnetic nano particle bulbec mixture
When start carry out current interference;Interference position includes the High temperature calibration position and specific sympathetic ganglion that skin temperature changes colour;It is described
Neuromere is sympathetic ganglion, includes, but are not limited to stellate ganglion, thoracic ganglia, lumbar ganglia, sacral ganglia etc..
2. device according to claim 1, it is characterised in that after previous operating modes 2-3 executes completion a cycle duration,
Control module controls whole system again and enters a new wheel working cycles, wherein transcranial magnetic stimulation is executed, checking with EMG method module
Motion Evoked Potential MEP and surface electromyogram signal are detected;When the I wave delay of epicycle induction does not reach same gender adult
When tranquillization, state of flaccid muscles on 1.5 times of ordinary duration, without judging whether MPF value rapid decrease or flash occurs,
It is directly entered operating mode 2-1;Operating time is set in operating mode 2-1 to be no less than 30 minutes, is guided in the period
Patient's abdominal respiration, and real-time detection MPF value it includes the total duration of previous operating modes 2-3 and are no more than 120 minutes.
3. device according to claim 2, it is characterised in that: where patient on platform in the alleviation massage mode 2-1
Lower direction applies magnetostatic field, size 0.6-0.9T;Backbone side is traced back in discoloration skin thermo-paint indicating positions to apply perpendicular to instruction point
Add ultrasound, ultrasound convergence depth 0.8-1.5cm, frequency 0.2-1MHz, power 1mW/ cm2;Transducer probe effective area 10mm
× 8mm, is close to skin, and corresponding neurode forms about 1 square centimeter of convergence region to convergent point under the skin;The assembling area
Domain leads to corresponding nerve fiber inner cell film depolarization, and the action potential of generation causes it to dominate skeletal muscle generation slight jitter;
In ultrasonication interval time, aforementioned checking with EMG method module is picked up myoelectricity near mark point;Pass through the feedback letter
Number to above-mentioned supersonic frequency size make adaptivity adjustment, adjustment direction be myoelectricity MPF value relative to a upper work week
There is raising trend in the record value that interim electromyography signal detection module obtains.
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