CN109289074A - A kind of wound healing material and its preparation method and application - Google Patents
A kind of wound healing material and its preparation method and application Download PDFInfo
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- CN109289074A CN109289074A CN201811169186.8A CN201811169186A CN109289074A CN 109289074 A CN109289074 A CN 109289074A CN 201811169186 A CN201811169186 A CN 201811169186A CN 109289074 A CN109289074 A CN 109289074A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a kind of wound healing materials and its preparation method and application.The wound healing material is membrane-like or foam product as made of glycosaminoglycan and oxidation of polysaccharides cross-linking reaction；Wherein, the glycosaminoglycan is one or more of hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, sulfonated chitosan, hydroxyl butyl chitosan, carboxymethyl chitosan, succinyl-chitosan or other chitosan derivatives；The oxidation of polysaccharides is one or more of oxidation of polysaccharides of the base containing dialdehyde, wherein the percentage that the sugar unit of the base containing dialdehyde accounts for the total sugar unit of polysaccharide molecule is 1%~70%.Wound healing material of the invention has preferable mechanical strength, flexibility, permeability, has the function of promoting empyrosis wound surface, ulcer wound surface and wound and wound surface healing, the significant healing time for shortening the surface of a wound.The application of wound healing material of the invention in the medical instrument that preparation treatment empyrosis wound surface, ulcer wound surface, wound and wound surface are treated, has a vast market foreground.
Description
Technical field
The present invention relates to a kind of medical material, more particularly to a kind of wound healing material and its preparation method and application,
Belong to technical field of pharmaceutical biotechnology.
Background technique
Surface of a wound ulcer is common in pressure ulcer caused by patient's apoplexy caused by cardiovascular and cerebrovascular disease, bedsore, glycosuria
Diabetic ulcer caused by patient's blood supply is bad, wound and wound surface ulcer caused by especially burning.Burn be due to flame,
Hot water, strong acid, highly basic etc. cause the normal organization of skin to be destroyed, and show as pain, sepage, swelling, cuticular breakdown.
Burn surface area, position and depth of burn difference, the locally and systemically reaction of patient is also different, and large area serious burn is then crisis
A kind of systemic disease of life needs to carry out from electrolyte balance, prevention and treatment infection, the heart, lung, Liver and kidney function variation etc.
Treatment.Therefore wound healing material is also the indispensable medical material of burn wound treatment, ulcer wound surface treatment, for covering
Lid and the protection surface of a wound, mitigate pain, absorb diffusate, wound healing, from bacterium infection etc..
There are two types of the medical dressing of clinical use is general: one is aerogel dressing, another kind is film dressing.Film applies
Material has good mechanical performance, can be with flap coverage and microbial barrier, offer gas exchanges.Ideal wound healing dressing
Need good histocompatbility, can flap coverage, and have good absorbency, gas permeability, antibiotic property, promoting healing
Can, a wet, slightly sour, low-oxygen environment is built for the surface of a wound, accelerates burn wound, ulcer wound surface healing.
Chitosan is a kind of natural polymer polycation polysaccharide, good biocompatibility, non-immunogenicity, nontoxic secondary work
With biological safety is good, while having a variety of effects such as hemostasis, analgesia, antibacterial, anti-infective, and can promote wound healing, is easy to
Diaphragm is made, there is the superperformance for preparing bleeding-stopping dressing, antibacterial dressing, wound healing dressing, burn dressing.It is with chitosan
Raw material prepare wound hemostasis, antibacterial, wound healing material have been reported.These reports are usually that chitosan is made not
It is dissolved in chitosan powder, chitosan film, chitosan sponge, chitin fiber and the fabric etc. of water, as wound healing dressing.But by
Limited in the functional effect of chitosan itself, the dressing effect of preparation is not satisfactory, needs chitosan and other and other materials
Material is used in combination, to improve the comprehensive performance of dressing.
Summary of the invention
The object of the present invention is to provide a kind of wound healing materials and its preparation method and application, to meet the prior art
The demand.
A kind of wound healing material, it is characterized in that membrane-like or sea as made of glycosaminoglycan and oxidation of polysaccharides cross-linking reaction
Continuous shape product；Wherein, the glycosaminoglycan is hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxyl
Propyl chitosan, sulfonated chitosan, hydroxyl butyl chitosan, carboxymethyl chitosan, succinyl-chitosan or other chitosans spread out
One or more of biology；The oxidation of polysaccharides is one or more of oxidation of polysaccharides of the base containing dialdehyde, wherein containing double
The percentage that the sugar unit of aldehyde radical accounts for the total sugar unit of polysaccharide molecule is 1%~70%.
The oxidation of polysaccharides of the base containing dialdehyde is oxidized starch derivative, oxycellulose derivative, oxidation algal polysaccharides
Derivative, amino-oxide group polysaccharide derivates, oxidized guar derivative, pullulan oxide derivative, oxidation xanthan gum spread out
One of biology, oxidized dextran derivative, oxidized dextran derivative or other oxidation plant polyose derivatives are several
Kind.
The preparation method of above-mentioned wound healing material, it is characterized in that: preparing weight respectively with sterile water or sterile saline
Measure the oxidation of polysaccharides glue that percentage concentration is 0.5~20%, 0.5~20% glycosaminoglycan glue；By oxidation of polysaccharides glue and ammonia
Carbohydrate gum liquid mixing in Quito quickly stirs evenly, by obtained mixing polysaccharide glue quickly in glass plate or stainless steel flat plate or
Prolong stream and knifing, natural drying or heat drying in polystyrene plate, obtains membrane-like wound healing material；Or it is mixed by what is obtained
It closes polysaccharide glue quickly to strike off in stainless steel or plastic mould, vacuum freeze drying obtains spongy wound healing material.
Above-mentioned wound healing material is answered in the medical instrument that empyrosis wound surface, ulcer wound surface, wound and wound surface are treated in preparation
With.
Wound healing material of the invention has preferable mechanical strength, flexibility, permeability, has and promotes burn and scald wound
The effect in face, ulcer wound surface and wound and wound surface healing, the significant healing time for shortening the surface of a wound, material non-toxic have preferable
Biocompatibility has the characteristics that easy to use, absorption amount of liquid is big.Therefore, wound healing material of the invention is controlled in preparation
Empyrosis wound surface, ulcer wound surface, the application in wound and wound surface dressing medical instrument are treated, is had a vast market foreground.
Specific embodiment
Below by specific embodiment, present invention be described in more detail.
One, the preparation of oxidation of polysaccharides
Embodiment 1: the preparation of oxidized starch
It weighs starch 15g, is added in 500ml Erlenmeyer flask, add water 200ml, heating stirring dissolution, with 5%(weight percent,
Oxidant NaIO is added to pH5.5 in aqueous acetic acid tune pH value similarly hereinafter)43.5g, sealing are protected from light stirring oxidation at room temperature
Reaction is for 24 hours.Reaction solution is fitted into the bag filter that molecular cut off is 3000 dalton, is protected from light, distills at 4 DEG C by end of reaction
Water is dialysed for 24 hours, wherein every 6h replacement distilled water is primary.After dialysis, the liquid in bag filter is freezed in freeze drier
Dry 48h, is made the oxidized starch 13.5g of the base containing dialdehyde, and double percent aldehydes are that the bis- percent aldehydes of 12.5%(are
Refer to that the sugar unit of the base containing dialdehyde in polysaccharide molecule accounts for the percentage of the total sugar unit of polysaccharide molecule, similarly hereinafter).
Embodiment 2: the preparation of oxidated carboxymethyl cellulose
Carboxymethyl cellulose powder 15g is weighed, is added in 1000ml Erlenmeyer flask, adds water 800ml, stirring and dissolving, with 5% vinegar
Oxidant KIO is added to pH5.5 in aqueous acid tune pH value48g, sealing are protected from light stirring oxidation reaction 60h at room temperature.Reaction
It finishes, is added with stirring 95% ethanol water of 4 times of volumes, precipitate, sediment filters, and is washed with 95% ethanol water
3 times, the oxidated carboxymethyl cellulose 12.1g of the base containing dialdehyde is made in dehydrated alcohol dehydration, vacuum drying, and dialdehyde base percentage contains
Amount is 62.5%.
Embodiment 3: the preparation of alginic acid is aoxidized
Sodium alginate 15g is weighed, is added in 1000ml Erlenmeyer flask, adds water 800ml, stirring and dissolving, with the hydrochloric acid of 1mol/L
Oxidant KIO is added to pH5.0 in aqueous solution tune pH value49g, sealing are protected from light stirring oxidation reaction 36h at 4 DEG C.It has reacted
Finish, by reaction solution is fitted into molecular cut off be 3000 dalton bag filter in, be protected from light, at 4 DEG C distilled water dialyse for 24 hours, wherein
Every 6h replacement distilled water is primary.After dialysis, the liquid in bag filter is freeze-dried 48h in freeze drier, is made and contains
The oxidized sodium alginate 13g of dialdehyde base, double percent aldehydes are 48.5%.
Embodiment 4: the preparation of oxidized chondroitin sulphate
Chondroitin sulfate 12.0g is weighed, is added in 500ml Erlenmeyer flask, adds water 200ml, stirring and dissolving, with the salt of 1mol/L
Oxidant NaIO is added to pH5.0 in aqueous acid tune pH value41g, sealing are protected from light stirring oxidation reaction 18h at 4 DEG C.Reaction
Finish, by reaction solution be fitted into molecular cut off be 3000 dalton bag filter in, be protected from light, at 4 DEG C distilled water dialysis for 24 hours,
In every 6h replacement distilled water it is primary.After dialysis, the liquid in bag filter is freeze-dried 48h in freeze drier, is made
The oxidized chondroitin sulphate 11.3g of the base containing dialdehyde, double percent aldehydes are 2.5%.
Embodiment 5: the preparation of oxidized hyaluronic acid
Hyaluronic acid 5g is weighed, is added in 1000ml Erlenmeyer flask, adds water 500ml, stirring and dissolving, with 5% aqueous acetic acid
It adjusts pH value to pH5.5, oxidant NaIO is added42.5g, sealing are protected from light stirring oxidation reaction for 24 hours at room temperature.End of reaction,
Reaction solution is fitted into the bag filter that molecular cut off is 3000 dalton, is protected from light, distilled water is dialysed for 24 hours, wherein every 6h at 4 DEG C
It is primary to replace distilled water.After dialysis, the liquid in bag filter is freeze-dried 48h in freeze drier, is made and contains dialdehyde
The oxidized hyaluronic acid 3.9g of base, double percent aldehydes are 30.8%.
In above-described embodiment 1~5, the oxidation of polysaccharides of the base containing dialdehyde is prepared for using periodate oxidation method.Periodic acid oxygen
Change method can aoxidize a variety of biological polyoses, such as starch, acetate starch and other starch derivatives, carboxymethyl cellulose
Element, hydroxyethyl cellulose, hydroxypropyl cellulose and other cellulose derivatives, sodium alginate, fucoidin, agar polysaccharide, liver
Element, chondroitin sulfate, hyaluronic acid, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxyl butyl chitosan, succinyl shell
Glycan, carboxymethyl chitosan and other chitosan derivatives, ethoxyl chitin, Hydroxypropyl chitosan, hydroxyl butyl chitin, carboxylic
Methyl chitin and other chitin derivativs, guar gum, hydroxypropyl guar gum and other guar derivatives, glucan are right
Other polysaccharide that the sugared acid anhydride of rotation and those skilled in the art can prepare, such as bletilla polysaccharide, aloe polysaccharide.Above-mentioned polysaccharide warp
After periodate oxidation, dialdehyde base is all contained in molecule, can be used as the raw material of wound healing material preparation of the present invention.
Two, the preparation of wound healing material
Raw material, container, vessel used in the preparation of the wound healing material etc. are germ-free condition, are prepared sterile
Under the conditions of complete, it is specific the preparation method is as follows:
Embodiment 6: the preparation of wound healing material 1
Oxidated carboxymethyl cellulose (double aldehyde group contents are 62.5%) 0.5g is weighed, is placed in the glass beaker of 100ml, is added molten
Agent sterile water 40ml stirs lower dissolution, obtains the oxidation of polysaccharides glue that weight percent concentration is 1.25%.It is poly- to weigh sulfonated shell
Sugared 0.8g, is placed in the glass beaker of 100ml, and solvent sterile water 40ml is added, and stirs lower dissolution, obtaining concentration expressed in percentage by weight is 2%
Glycosaminoglycan glue.40ml oxidation of polysaccharides glue is poured into 40ml glycosaminoglycan glue, equal proportion stirs evenly, and obtains
Mixing polysaccharide glue be quickly poured on clean glass plate (or stainless steel flat plate or polystyrene plate) and prolong stream and knifing,
Control glue dosage, make dry film with a thickness of 100~1000 μm, spontaneously dry (or heat drying), obtain membrane-like wound healing
Material 1.
Embodiment 7: the preparation of wound healing material 2
Oxidation alginic acid (double aldehyde group contents are 48.5%) 2g is weighed, is placed in the glass beaker of 100ml, the sterile life of solvent is added
Salt water 40ml is managed, lower dissolution is stirred, obtains the oxidation of polysaccharides glue that weight percent concentration is 5%.Hydroxypropyl chitosan 4g, is placed in
In the glass beaker of 100ml, solvent sterile saline 40ml is added, stirs lower dissolution, obtains the ammonia that concentration expressed in percentage by weight is 10%
Quito carbohydrate gum liquid.40ml oxidation of polysaccharides glue is poured into 40ml glycosaminoglycan glue, equal proportion stirs evenly, and what is obtained is mixed
It closes polysaccharide glue and is quickly poured on clean glass plate (or stainless steel flat plate or polystyrene plate) and prolong stream and knifing, control
Glue dosage, make dry film with a thickness of 200~1500 μm, spontaneously dry (or heat drying), obtain membrane-like wound healing material
2。
Embodiment 8: the preparation of wound healing material 3
It weighs oxidized starch (double aldehyde group contents are 12.5%) 3.5g, weighs oxidized hyaluronic acid (double aldehyde group contents are 30.8%)
2.5g is placed in the glass beaker of 100ml, and sterile aqueous solvent 40ml is added, and stirs lower dissolution, obtaining weight percent concentration is
15% oxidation of polysaccharides glue.Hydroxyethyl chitosan 3g is weighed, succinyl-chitosan 3g is weighed, is placed in the glass beaker of 100ml
In, sterile aqueous solvent 40ml is added, stirs lower dissolution, obtains the glycosaminoglycan glue that concentration expressed in percentage by weight is 15%.40ml is aoxidized
Polysaccharide glue pours into 40ml glycosaminoglycan glue, and equal proportion stirs evenly, and obtained mixing polysaccharide glue is quickly poured into 50mm
It in stainless steel (or plastics) mold of × 50mm × 5mm, strikes off, is put into vacuum freeze drier and freezes 2~10 hours for -45 DEG C
Afterwards, vacuum freeze drying 36~48 hours obtain spongy wound healing material 3.
In the preparation of 6~8 wound healing material of above-described embodiment, the oxidation of polysaccharides, it is characterized in that base containing dialdehyde
One or more of oxidation of polysaccharides, wherein the sugar unit of the base containing dialdehyde account for the percentage of the total sugar unit of polysaccharide molecule be 1%~
70%.The oxidation of polysaccharides is oxidized starch derivative, oxycellulose derivative, oxidation marine algae polysaccharide derivant, oxidation
Glycosaminoglycan derivative, oxidized guar derivative, pullulan oxide derivative, oxidation xanthan derivatives, oxidation Portugal
Polysaccharid derivative, oxidized dextran derivative or other oxidation plant polyose derivatives all contain in the molecule of oxidation of polysaccharides
Dialdehyde base can reach similar effect.The oxidized starch derivative refers to oxidized starch, oxidation acetate starch, or
Other oxidized starch derivatives；The oxycellulose derivative refers to oxidated carboxymethyl cellulose, oxidation hydroxy ethyl fiber
Element, oxidation hydroxypropyl cellulose or other oxycellulose derivatives；The oxidation marine algae polysaccharide derivant, refers to oxidation
Seaweed acid polysaccharide, oxidation fucoidin or oxidation agar polysaccharide；The amino-oxide group polysaccharide derivates, refer to heparin,
Oxidized chondroitin sulphate, oxidized hyaluronic acid, oxidation chitosan, oxidation hydroxyethyl chitosan, oxidation hydroxypropyl chitosan, oxidation
Hydroxyl butyl chitosan, oxidation succinyl-chitosan, oxidated carboxymethyl chitosan, oxidation ethoxyl chitin, oxidation hydroxypropyl first
Oxidation chitosan derivatives, the oxidation of shell element, oxidation hydroxyl butyl chitin, oxidated carboxymethyl chitin or other bases containing dialdehyde
Chitin derivativ；The oxidized guar derivative refers to oxidized guar, oxidation hydroxypropyl guar gum or other contains
Oxidized guar derivative；Other oxidation plant polyose derivatives refer to oxidation bletilla polysaccharide, oxidizing aloe polysaccharide,
Or and other oxidation plant polyoses.
In the preparation of 6~8 wound healing material of above-described embodiment, the glycosaminoglycan is it is characterized in that hyalomitome
Acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, sulfonated chitosan, hydroxyl butyl shell are poly-
One or more of sugar, carboxymethyl chitosan, succinyl-chitosan or other chitosan derivatives.
Three, application of the wound healing material as burn and scald treatment dressing
Embodiment 9: application of the wound healing material as the biomaterial for promoting the healing of burn and scald ulcer wound surface
The deep II degree of scald Ulcer Models preparation of rat and GP TH: using rat as experimental animal, rat burn and scald is made
Model evaluates wound healing material of the invention to the promotion Healing of empyrosis wound surface.Test rat 24, male and female are each
Half, weight 220g ± 20 are divided into negative control group, 1 group of experiment, 2 groups, every group 8 of experiment.Rat back is taken off with depilatory cream
Hair, physiological saline wiped clean, intraperitoneal injection 3% yellow Jackets anesthesia.The bottomless triangular flask of bore 2.2cm is inverted in rat
At dorsal midline depilation, built-in 99 DEG C of hot water 300mL scald 18s, the deep II degree of scald Ulcer Models of production rat.It is tied in scald
Shu Shiyong sterile razor blade strikes off superficial cortical layers at scald, and physiological saline is by surface of a wound wiped clean.The scald of negative control group rat
The surface of a wound does not do treatment processing, 1 group of experiment the burned rats surface of a wound attach sterile film sheet wound healing material 2(length and width be 3cm ×
3cm), testing 2 groups and attaching sterile spongy wound healing material 3(length and width in the burned rats surface of a wound is 3cm × 3cm), each group wound
Face sticks Sterilized application and fixes, and rat single cage is raised after experiment, observes wound healing situation daily, and the surface of a wound is replaced in every 3d carefulness
Material.
The deep II degree of scald ulcer wound surface healing state of rat: 1d after scald, control group surface of a wound flush, organized liquid exudation；
Test 1 group, 2 groups of surface of a wound it is more wet, material and the surface of a wound bond, no obvious tissue fluid exudation.7d after scald, control group crust compared with
Thickness, substrate whiting；Test 1 group, 2 groups of crust peripheries start dissolution strip off.14d after scald, the thick hard and face of control group surface of a wound crust
Color is dark red, and the dissolution of group crust periphery is obvious, and partial exfoliation forms new skin.21d after scald, the dissolution of control group crust periphery
It falls off, newborn epidermis occurs；1 group, the largely healing of 2 groups of surface of a wound are tested, intermediate fraction healing is incomplete.Experimental result is aobvious
Show, the healing of wound healing material II degree of scald ulcer wound surface deep to rat has facilitation, compared with the control group, significant to contract
The healing time of the short surface of a wound.
Wound healing material of the invention has preferable mechanical strength, flexibility, permeability, has and promotes burn and scald wound
The effect that face, ulcer wound surface heal, the significant healing time for shortening the surface of a wound, material non-toxic have preferable biocompatibility.
Therefore, wound healing material of the invention can prepare empyrosis wound surface, ulcer wound surface, wound and wound surface treatment dressing medical treatment
It applies in instrument, is developed as medical instrument, for treating empyrosis wound surface, ulcer wound surface and wound and wound surface, had wide
Wealthy market prospects.
Claims (10)
1. a kind of wound healing material, it is characterized in that membrane-like or sponge as made of glycosaminoglycan and oxidation of polysaccharides cross-linking reaction
Shape product；Wherein, the glycosaminoglycan is hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl
Base enclosure glycan, sulfonated chitosan, hydroxyl butyl chitosan, carboxymethyl chitosan, succinyl-chitosan or other chitosan derivatives
One or more of object；The oxidation of polysaccharides is one or more of oxidation of polysaccharides of the base containing dialdehyde, wherein containing dialdehyde
The percentage that the sugar unit of base accounts for the total sugar unit of polysaccharide molecule is 1%~70%.
2. wound healing material as described in claim 1, it is characterized in that the oxidation of polysaccharides of the base containing dialdehyde, is oxidized starch
Derivative, oxycellulose derivative, oxidation marine algae polysaccharide derivant, amino-oxide group polysaccharide derivates, oxidized guar are derivative
Object, pullulan oxide derivative, oxidation xanthan derivatives, oxidized dextran derivative, oxidized dextran derivative,
Or one or more of other oxidation plant polyose derivatives.
3. wound healing material as claimed in claim 2, it is characterized in that the oxidized starch derivative refer to oxidized starch,
Aoxidize acetate starch or other oxidized starch derivatives.
4. wound healing material as claimed in claim 2, it is characterized in that the oxycellulose derivative refers to oxidation carboxylic
Methylcellulose, oxidation hydroxyethyl cellulose, oxidation hydroxypropyl cellulose or other oxycellulose derivatives.
5. wound healing material as claimed in claim 2, it is characterized in that the oxidation marine algae polysaccharide derivant refers to oxidation
Seaweed acid polysaccharide, oxidation fucoidin or oxidation agar polysaccharide.
6. wound healing material as claimed in claim 2, it is characterized in that the amino-oxide group polysaccharide derivates refer to oxidation
Heparin, oxidized chondroitin sulphate, oxidized hyaluronic acid, oxidation chitosan, oxidation hydroxyethyl chitosan, oxidation hydroxypropyl
Sugar, oxidation hydroxyl butyl chitosan, oxidation succinyl-chitosan, oxidated carboxymethyl chitosan, oxidation ethoxyl chitin, oxidation hydroxyl
Propyl chitin, the oxidation chitosan derivative for aoxidizing hydroxyl butyl chitin, oxidated carboxymethyl chitin or other bases containing dialdehyde
Object, oxidated chitin derivative.
7. wound healing material as claimed in claim 2, it is characterized in that the oxidized guar derivative refers to oxidation melon
That glue, oxidation hydroxypropyl guar gum or other oxidized guar derivatives.
8. wound healing material as claimed in claim 2, it is characterized in that other oxidation plant polyose derivatives refer to
Aoxidize bletilla polysaccharide or oxidizing aloe polysaccharide.
9. the preparation method of the described in any item wound healing materials of claim 1-8, it is characterized in that the following steps are included: with nothing
Bacterium water or sterile saline prepare the oxidation of polysaccharides glue that concentration expressed in percentage by weight is 0.5~20%, 0.5~20% ammonia respectively
Quito carbohydrate gum liquid；Oxidation of polysaccharides glue is mixed with glycosaminoglycan glue, is quickly stirred evenly, the mixing polysaccharide glue that will be obtained
Quickly prolong stream and knifing, natural drying or heat drying on glass plate or stainless steel flat plate or polystyrene plate, obtains film
Sheet wound healing material；Or obtained mixing polysaccharide glue is quickly struck off in stainless steel or plastic mould, vacuum refrigeration
It is dry, obtain spongy wound healing material.
10. the described in any item wound healing materials of claim 1-8 treat empyrosis wound surface, ulcer wound surface, wound in preparation
Application in the medical instrument of the surface of a wound.
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Cited By (5)
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| CN113174060A (en) * | 2021-03-22 | 2021-07-27 | 中国海洋大学 | Alginic acid-chitosan oligosaccharide-zinc oxide composite hydrogel and preparation method and application thereof |
| CN113941026A (en) * | 2021-10-25 | 2022-01-18 | 浙江中医药大学 | Bioactive glass-coated chitosan cellulose derivative-based injectable hydrogel dressing and preparation method thereof |
| CN114533934A (en) * | 2022-03-31 | 2022-05-27 | 四川大学 | Novel healing-promoting collagen-based biomedical wound dressing and preparation method thereof |
| CN115737887A (en) * | 2022-11-07 | 2023-03-07 | 河北大学 | Skin wound dressing and preparation method thereof |
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