CN109288069A - A kind of enteral nutrition preparation reducing diarrhea - Google Patents

A kind of enteral nutrition preparation reducing diarrhea Download PDF

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Publication number
CN109288069A
CN109288069A CN201811437894.5A CN201811437894A CN109288069A CN 109288069 A CN109288069 A CN 109288069A CN 201811437894 A CN201811437894 A CN 201811437894A CN 109288069 A CN109288069 A CN 109288069A
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parts
chitosan
preparation
protein
enteral nutrition
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陆守荣
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Wuxi Peoples Hospital
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Wuxi Peoples Hospital
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Priority to CN201811437894.5A priority Critical patent/CN109288069A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus

Abstract

The invention discloses a kind of enteral nutrition preparations containing chitosan, probiotics and dietary fiber, it is suitble to the elderly patients of dysphagia edible, delicate mouthfeel, it is easy to digest, help to repair gut barrier, elderly patients' nutrition can be significantly improved, is immune, nervous function, more commercially available EN can be reduced the generation of diarrhea.Its composition of EN disclosed by the invention is as follows by weight: nutriment: it is 10-15 parts of protein, 20-30 parts fatty, 40-50 parts of carbohydrate；Thickener: 1-5 parts of chitosan, 1-5 parts of chitosan oligosaccharide；Probiotics: 0.01-0.1 parts of Lactobacillus rhamnosus LGG, 0.01-0.1 parts of bacillus subtilis；Other compositions: 1-5 parts of kanjak mannan oligosaccharides.

Description

A kind of enteral nutrition preparation reducing diarrhea
Technical field
It is being used the present invention relates to special medicine purposes diet field more particularly to a kind of suitable elderly patients, can reduce The enteral nutrition preparation and its methods for making and using same of diarrhea.
Background technique
Enteral nutrition (enteral nutrition, EN) refers to that oral or tube feed provides the method for nutritional support for body. Enteral nutrition not only conforms with physiology and spends low, it has also become the nutritional support method of current clinically first choice.But enteral nutrition There are many complication, such as diarrhea.Diarrhea of patients undergoing is the most common complication of enteral nutrition during enteral nutrition, and The main reason for enteral nutrition treatment interrupts.Foreign literature report: the incidence of diarrhea of patients undergoing is up to 11.3% during enteral nutrition ~66.1%, diarrhea will lead to nutrition substance lose, Water-Electrolyte disturbance of acid-base balance, and when extending patient and being hospitalized Between, reduce quality of life of patients, increase nursery work burden etc..
The component ratio of enteral nutrition preparation, osmotic pressure are the reason of enteral nutrition induced diarrhea occurs, enteral battalion The osmotic pressure for supporting preparation is more than that 400mOsm/L will cause osmotic diarrhea, therefore the EN osmotic pressure of clinical use exists more at present 279~330m Osm/L, however EN main component is water, carbohydrate, fat, protein, fat content is excessively high, energy is excessively high can Cause diarrhea.With the exploitation of EN, it is added to oligosaccharide, disaccharides, monosaccharide and polyalcohol in the EN of most of commercializations, wherein short Chain carbohydrate is also the reason of EN diarrhea occurs.
EN supply mode also will affect the incidence of diarrhea, as nutritional preparation infusion amount is excessive, infusion velocity is too fast, temperature The preservation of too low and syringe was not contaminated at that time, was likely to result in diarrhea.The state of patient also has relationship, such as hypoproteinemia Disease patient, infected patient, older patient are easier that diarrhea, hemodynamic instability, diabetes, mechanical ventilation occurs Also all have an impact.Patient is taking other drugs, the potassium as contained in antibiotic, antacids, gastro-kinetic agent and excipient substance, mountain Pears alcohol etc. will affect the generation of diarrhea.
Summary of the invention
In view of the above-mentioned problems, the present invention provides a kind of, the liquid enteral containing chitosan, probiotics and dietary fiber is sought Preparation is supported, is formed as follows by weight:
Nutriment: it is 10-15 parts of protein, 20-30 parts fatty, 40-50 parts of carbohydrate；Thickener: chitosan 1-5 Part, 1-5 parts of chitosan oligosaccharide；Probiotics: 0.01-0.1 parts of Lactobacillus rhamnosus LGG, 0.01-0.1 parts of bacillus subtilis；Other Ingredient: 1-5 parts of kanjak mannan oligosaccharides.
Wherein the protein is vegetable protein or hydrolyzing lactoalbumin, and preferred vegetable protein is soya-bean polypeptides；Institute The fat stated is vegetable oil or fish oil, and preferred vegetable oil is corn oil or soybean oil, and preferred fatty material form is micro- glue Capsule powder；The preferred cornstarch of the carbohydrate or dextrin or pea fibre.The deacetylating degree of chitosan > 90%, Viscosity is 600-800mpa.s, granularity 100-120 mesh.The chitosan oligosaccharide molecular weight < 3000, wherein chitobiose~shell six is sugared Total amount > 80%.The total amount > 90% of the sugar of the disaccharides contained in the kanjak mannan oligosaccharides~seven, contents more than eight sugar < 5%, monosaccharide < 3%.Microelement, the minerals and vitamins of needed by human body can be also added in other compositions.
Specific preparation process is as follows:
(1) it takes the chitosan, chitosan oligosaccharide and kanjak mannan oligosaccharides of constant weight to be dissolved in 80~90 DEG C of hot water, is stirred Uniformly to being completely dissolved；
(2) it takes the protein, fat and carbohydrate of constant weight to be dissolved in the solution of step (1), is uniformly mixed；
(3) solution to step (2) naturally cools to 50 DEG C hereinafter, Lactobacillus rhamnosus LGG, bacillus subtilis is added Bacterium is uniformly mixed.
The volume of hot water used in step (1), with all nutriments (including protein, fat, carbohydrate, shell Glycan, chitosan oligosaccharide, Lactobacillus rhamnosus LGG, bacillus subtilis, kanjak mannan oligosaccharides) weight ratio, be 3: 1~4: 1.
Using above scheme, enteral nutrition preparation of the invention is had the advantage that
Thickener of the chitosan as enteral nutrition preparation is used for the first time.Chitosan is national food additive standard GB2760 allow using thickener, be natural high molecular material completely, natural generation can be generated by the intracorporal enzyme degradation of biology Thank to object, nontoxic, can be fully absorbed by organism, the metabolite Glucosamine bone and joint diseases common for the elderly have more Benifit.
Chitosan compounding chitosan oligosaccharide and kanjak mannan oligosaccharides can play protection to the probiotics added in nutritional preparation and make With.According to common sense recognized within the industry, it is very difficult that probiotics survives in liquid, and nutritional preparation provided by the present invention program, Due to the protective effect of chitosan, chitosan oligosaccharide and kanjak mannan oligosaccharides, it can guarantee added bacillus subtilis and rhamnose The viable bacteria amount of survival of lactobacillus reaches 70% or more, improves probiotics in the field planting rate of enteron aisle, reduces enteral battalion to reach Phenomena such as supporting the common diarrhea of preparation, indigestion.
Inventor has surprisingly found that the enteral nutrition preparation that this programme provides is in addition to providing battalion to gerontal patient in an experiment Support is supported, with good in terms of reduction infection, improving immune function, improving nervous function index, reduce Performance, can be described in detail in following embodiment.
Detailed description of the invention
Fig. 1 gives content (the unit Lg CFU/ of bacillus subtilis in different times gerontal patient's excrement after nutritional preparation g)
A indicate be not added with chitosan oligosaccharide and mannan-oligosaccharides group as a result, B indicate be to be prepared by scheme of the invention The result figure 2 of group gives the principal component analysis figure of different times gerontal patient's faecal microbiota structure after nutritional preparation
Specific embodiment
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
Embodiment 1
Nutritional preparation is prepared by consisting of: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 1 part of chitosan oligosaccharide, 0.1 part of Lactobacillus rhamnosus LGG, 0.1 part of bacillus subtilis, 5 parts of kanjak mannan oligosaccharides.
Wherein the protein is soya-bean polypeptides；The fat is corn oil microcapsule powder；The carbon hydrate Object is cornstarch.The chitosan of different deacetylations is selected, respectively 80%, 85%, 90%, 95% prepare four parts of nutrition Preparation.The chitosan oligosaccharide molecular weight < 3000, wherein the total amount > 80% of the sugar of chitobiose~shell six.The kanjak mannan is few The total amount > 90% of the sugar of the disaccharides contained in sugar~seven, more than eight sugar content < 5%, monosaccharide < 3%.
Specific preparation process is as follows:
(1) it takes chitosan, chitosan oligosaccharide and kanjak mannan oligosaccharides to be dissolved in 80~90 DEG C of hot water, is uniformly mixed to completely Dissolution；
(2) it takes protein, fat and carbohydrate to be dissolved in the solution of step (1), is uniformly mixed；
(3) solution to step (2) naturally cools to 50 DEG C hereinafter, Lactobacillus rhamnosus LGG, bacillus subtilis is added Bacterium is uniformly mixed.
The volume of hot water used in step (1), with all nutriments (including protein, fat, carbohydrate, shell Glycan, chitosan oligosaccharide, Lactobacillus rhamnosus LGG, bacillus subtilis, kanjak mannan oligosaccharides) weight ratio, be 3: 1.
Embodiment 2, scheme of the invention are to the survival of probiotics and the facilitation of field planting
Two kinds of enteral nutrition preparations are prepared in the method that the present invention program provides, the difference is that A does not add chitosan oligosaccharide and evil spirit Taro manna oligosacchride.
The formula of nutritional preparation A: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, rhamnose cream 0.1 part of bacillus LGG, 0.01 part of bacillus subtilis.
The formula of nutritional preparation B: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, chitosan oligosaccharide 1 Part, 0.01 part, 0.1 part of Lactobacillus rhamnosus LGG, 0.01 part of bacillus subtilis, 1 part of kanjak mannan oligosaccharides.
20 Hospitalized Aged Patients are collected, are distinguished as two groups of A, B, every group of each 10 people, A group average age 70.2 years old, men and women Each 5 people, B group average age 70.2 years old, 4 people of male 6 people female.A group patient gives nutritional preparation A, and B group patient give nutritional preparation B, 7 days (continuous 28 days) respectively in administration 0,7,14,21 day, and after cutting out, 14 days (continuous 35 days), acquire excrement sample This, the method combined using RT-PCR and pyrosequencing techniques analyzes the amount of bacillus subtilis in different number of days excrement. And number of cases occurs for the diarrhea for recording patient in continuous 35 days.As a result 3 and Fig. 1 be see the table below.
Number of cases statistics occurs for 3 continuous 35 days diarrhea of patients undergoing of table
7 days 14 days 21 days 28 days 35 days It is total
A 4 3 3 3 3 16
B 1 0 0 0 1 2
By the analysis result of Fig. 1 it is found that the rate of rise of bacillus subtilis is significantly higher than A group in B group patient's excrement, say The bright chitosan oligosaccharide and kanjak mannan oligosaccharides of being added to can significantly protect probiotics in the survival rate of liquid condition, and be finally reached intestines Road is colonized.After stopping two weeks, Bacillus subtilis number is 2 times before taking in B group patient's excrement, and A group is suffered from In person's excrement Bacillus subtilis number substantially with take before it is close, illustrate that being added to chitosan oligosaccharide and kanjak mannan oligosaccharides can show It writes and promotes probiotics in the field planting of enteron aisle, improve the Bacterial community of enteron aisle, make patient after stopping giving enteral nutrition preparation, Good intestinal microecology can also be kept to balance whithin a period of time, so embodying the less phenomenon of diarrhea number of cases；A group patient Also occur the diarrhea of more number of cases early stage giving nutritional preparation, illustrate added by probiotics intestinal colonisation situation not It is good, thus patient does not tolerate the nutriment added suddenly more.
Shown using OUT significance analysis methods and results when not taking nutritional preparation (0 day), two groups of patient's excrement of A, B There was no significant difference for microorganism composition, and after administration 21 days and stopping administration 14 days, the significant difference of A group and B group patient is said Bright nutritional preparation B produces larger impact to the abundance of Intestinal Mucosal Injury in Patients Undergoing microorganism.Result (Fig. 2) is observed using Principal Component Analysis It can be found that B group Intestinal Mucosal Injury in Patients Undergoing microorganism be formed in it is whole before distributing position on principal component figure is relatively taken be biased to lower right, be by After probiotics field planting in nutritional preparation, make acidfast bacilli door (Acidobacteria), the green curved bacterium door in enteron aisle (Chloroflexi), deferrization bacillus door (Deferribacteres), Fusobacterium door (Fusobacteria), Proteobacteria (Proteobacteria), mould door (Planctomycetes), spirillum door (Spirochaete), wart germ door are floated (Verrucomicrobia) caused by being decreased obviously.Illustrate probiotics contained in nutritional preparation B in intestinal colonisation better off, Change Intestinal Mucosal Injury in Patients Undergoing Bacterial community, improves intestinal microecology.
Embodiment 3, scheme of the invention are to the metabolism of gerontal patient's nutrition in postoperative, the influence of gut barrier
Two kinds of enteral nutrition preparations of A, B are prepared in the method that the present invention program provides, the difference is that selected probiotics Difference is formulated as follows:
A: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 3 parts of chitosan oligosaccharide, streptococcus thermophilus 0.1 part, 0.1 part of bacillus subtilis, 0.1 part of saccharomyces cerevisiae, 1 part of kanjak mannan oligosaccharides.
B: 10 parts of protein, 20 parts of fat, 40 parts of carbohydrate, 3 parts of chitosan, 3 parts of chitosan oligosaccharide, Lactobacillus rhamnosus LGG0.1 parts, 0.1 part of bacillus subtilis, 1 part of kanjak mannan oligosaccharides.
Wherein the protein is hydrolyzing lactoalbumin；The fat is fish oil micro-capsule powder；The carbon aquation Conjunction object is cornstarch.The deacetylating degree of chitosan > 90%, viscosity 600-800mpa.s, granularity 100-120 mesh.Institute The chitosan oligosaccharide molecular weight < 3000 stated, wherein the total amount > 80% of the sugar of chitobiose~shell six.Contain in the kanjak mannan oligosaccharides The total amount > 90% of the sugar of some disaccharides~seven, more than eight sugar content < 5%, monosaccharide < 3%.
Selection abdominal postoperative, the age, gastrointestinal function was normal, no body at gerontal patient 20 of 60~80 one full year of life Again overweight/to kick the beam (in ± 15% range of standard weight), vital sign is steady.From postoperative 3rd day, enteral nutrition system is given Agent, the 10th day detection blood plasma prealbumin, albumin, immunoglobulin；Nitrogen enters the nitrogen output of amount and urine, excrement；Mannitol in urine (L) and the content of lactulose (M).As a result 4 be see the table below.
The variation of table 4 perioperatively nutrition and gut barrier index
As can be seen from Table 4, B group blood plasma glutamine concentration is significantly higher than A group, p < 0.05；B group prealbumin and The a little higher than A group of albumin；There were significant differences (p < 0.05) for two groups of intestinal permeabilities of AB, and B group intestinal permeability is significantly lower than A group.The elderly patients of the abdominal postoperative normal for gut function, enteral nutrition preparation can satisfy its nutritional need, Albumen is decomposed in small intestine to be absorbed, and is decomposed the main energy sources that the glutamine generated is protection of intestinal mucosal barrier cells, can be maintained the normal of intestines The height of permeability and villus.Under the stress situations such as operation, wound, the glutamine of muscle and intrapulmonary accelerates outflow, be intestines, Immunocyte and kidney provide substrate, so that free glutamine concentration be caused to be remarkably decreased.It can be seen from the results that B group is selected Probiotics is unexpectedly more advantageous to enteral nutrition supplement and absorbs, and more obviously increases blood glutamine concentration, thus It safeguards gut barrier and improves immune function and reduce various Infective morbidities.
The nitrogen balance that A group adds up 7d is -6.5 ± 0.87mg/kg, and the nitrogen balance that B group adds up 7d is 31.5 ± 0.98mg/ Kg, there were significant differences for comparison among groups；The preoperative IgG difference with postoperative 10d of A group is that 0.85, IgM difference is that 0.08, B is preoperative and art It is 0.17 that the IgG difference of 10d, which is 1.09, IgM difference, afterwards, has significant difference between group.Illustrate that scheme of the invention is selected prebiotic Bacterium Lactobacillus rhamnosus LGG, bacillus subtilis combination, can play better nutrition support effect, and significantly improve The content of immunoglobulin can be reduced the incidence of postoperative infection.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is without wound The property made labour, which according to the present invention can conceive, makes many modifications and variations, and micro member is such as added in other nutritional ingredients Element and vitamin, mutually should be able to bring beneficial effect.Therefore all technician in the art exist under this invention's idea It, all should be by right by logic analysis, reasoning or the limited available technical solution of test on the basis of the prior art In protection scope determined by claim.

Claims (6)

1. one kind can reduce the enteral nutrition preparation of diarrhea, form as follows by weight:
Nutriment: it is 10-15 parts of protein, 20-30 parts fatty, 40-50 parts of carbohydrate；Thickener: 1-5 parts of chitosan, 1-5 parts of chitosan oligosaccharide；Probiotics: 0.01-0.1 parts of Lactobacillus rhamnosus LGG, 0.01-0.1 parts of bacillus subtilis；Other at Point: 1-5 parts of kanjak mannan oligosaccharides.
2. EN as described in claim 1, it is characterized in that, in the nutriment, protein is vegetable protein or hydrolyzed whey Albumen, preferred vegetable protein are soya-bean polypeptides；The fat be vegetable oil or fish oil, preferred vegetable oil be corn oil or Soybean oil, preferred fatty material form are microcapsule powder；The preferred cornstarch of the carbohydrate or dextrin or pea Fiber.
3. EN as described in claim 1, it is characterized in that, in the thickener, deacetylating degree of chitosan > 90%, viscosity is 600-800mpa.s granularity 100-120 mesh；Chitosan oligosaccharide molecular weight < 3000, wherein the total amount > 80% of the sugar of chitobiose~shell six.
4. EN as described in claim 1, it is characterized in that, in the other compositions, the disaccharides that contains in kanjak mannan oligosaccharides~ The total amount > 90% of seven sugar, more than eight sugar content < 5%, monosaccharide < 3%；Microelement, the mine of needed by human body can also be added Substance and vitamin.
5. the preparation method of EN described in claim 1, its feature is as follows:
Specific preparation step:
(1) it takes the chitosan, chitosan oligosaccharide and kanjak mannan oligosaccharides of constant weight to be dissolved in 80~90 DEG C of hot water, is uniformly mixed To being completely dissolved；
(2) it takes the protein, fat and carbohydrate of constant weight to be dissolved in the solution of step (1), is uniformly mixed；
(3) solution to step (2) naturally cools to 50 DEG C hereinafter, addition Lactobacillus rhamnosus LGG, bacillus subtilis, are stirred It mixes uniformly mixed；
(4) in step (1) hot water used volume, total weight ratio with the solid component of all nutritional preparations is 3: 1~4: 1.
6. the EN that preparation method described in EN described in claim 1 or claim 5 obtains is in preparation for aphetite disorder The purposes of the enteral nutrition preparation of gerontal patient.
CN201811437894.5A 2018-11-29 2018-11-29 A kind of enteral nutrition preparation reducing diarrhea Pending CN109288069A (en)

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CN102573862A (en) * 2009-09-20 2012-07-11 美赞臣营养品公司 Probiotic stabilization
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CN107616983A (en) * 2017-01-13 2018-01-23 江苏西宏生物医药有限公司 A kind of anti-diarrhea enteral nutrition composition

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