CN109276640A - A kind of moistening lung composition and application, tobacco powder and application method - Google Patents

A kind of moistening lung composition and application, tobacco powder and application method Download PDF

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Publication number
CN109276640A
CN109276640A CN201811431408.9A CN201811431408A CN109276640A CN 109276640 A CN109276640 A CN 109276640A CN 201811431408 A CN201811431408 A CN 201811431408A CN 109276640 A CN109276640 A CN 109276640A
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parts
moistening lung
peppermint
lung
chinese ephedra
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刘广超
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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Abstract

The invention discloses a kind of moistening lung composition and applications, tobacco powder and application method, belong to field of Chinese medicinal composition.The moistening lung composition includes following component: yellow wingceltis, peppermint, Chinese ephedra, almond, dried orange peel and tendril-leaved fritillary bulb.Optionally, moistening lung composition includes following component: 8~15 parts of yellow wingceltis, 10~50 parts of peppermint, 10~50 parts of Chinese ephedra, 3~8 parts of almond, 10~50 parts of dried orange peel and 3~8 parts of tendril-leaved fritillary bulb.Moistening lung composition of the invention can be applied to the imbedibility drug of preparation moistening lung to arrest cough, such as tobacco powder.Moistening lung composition of the invention have effects that it is relieving cough and reducing sputum, freeing lung and relieving asthma, inducing resuscitation is had one's ideas straightened out, removing heat from the lung and relieving sorethroat, can be used for the symptoms such as giddy caused by treating anemofrigid cold, head heavy, cough, abundant expectoration, lung's discomfort.

Description

A kind of moistening lung composition and application, tobacco powder and application method
Technical field
The present invention relates to moistening lung product technical field, in particular to a kind of moistening lung composition and application, tobacco powder and user Method.
Background technique
Anemofrigid cold easily causes the infection of the upper respiratory tract, and serious person leads to acute bronchitis, and patient's cardinal symptom is cough, More phlegm.Even if common cold is good, cough can also continue two to three week, if cough do not stop, by it is acute switch to it is chronic, often to suffer from Person brings very big pain, such as uncomfortable in chest, pharynx itch, breathe, and lung extremely feels bad.At present frequently with the mode pair of anti-inflammatory drug for oral administration Such symptom is treated, it is still necessary to a kind of drug for acting from the outside in lung, come improve cough, more phlegm, lung's discomfort disease Shape.
Summary of the invention
The embodiment of the invention provides a kind of moistening lung composition and applications, tobacco powder and application method, for freeinging lung and relieving asthma, only Cough resolving sputum and removing heat from the lung and relieving sorethroat.In order to which some aspects of the embodiment to disclosure have a basic understanding, it is shown below simple Summary.The summarized section is not extensive overview, nor to determine key/critical component or describe these embodiments Protection scope.Its sole purpose is that some concepts are presented with simple form, in this, as the preamble of following detailed description.
According to a first aspect of the embodiments of the present invention, a kind of moistening lung composition is provided, the moistening lung composition includes such as Lower component:
Yellow wingceltis, peppermint, Chinese ephedra, almond, dried orange peel and tendril-leaved fritillary bulb.
In some optional embodiments, the moistening lung composition is grouped as by the group of following parts by weight:
8~15 parts of yellow wingceltis, 10~50 parts of peppermint, 10~50 parts of Chinese ephedra, 3~8 parts of almond, 10~50 parts of dried orange peel and tendril-leaved fritillary bulb 3 ~8 parts.
In some optional embodiments, the moistening lung composition is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
In some optional embodiments, the peppermint is dried peppermint leaf or peppermint oil.
In some optional embodiments, the Chinese ephedra is that Chinese ephedra section plus ripe sweet frying form.
In some optional embodiments, the almond is that semen armeniacae amarae is placed in heating in boiling water to obtain.
According to a second aspect of the embodiments of the present invention, moistening lung composition described in aforementioned any alternative embodiment is provided to make Application in the imbedibility drug of standby moistening lung to arrest cough.
In some optional embodiments, the imbedibility drug is tobacco powder.
According to a third aspect of the embodiments of the present invention, a kind of tobacco powder is provided, comprising as described in aforementioned any alternative embodiment Moistening lung composition.
According to a fourth aspect of the embodiments of the present invention, a kind of application method of tobacco powder is provided, comprising: lighting tobacco powder makes it Flue gas is generated, user breathes the air for being mixed with flue gas.
Technical solution provided in an embodiment of the present invention can include the following benefits:
Moistening lung composition of the invention contains peppermint and Chinese ephedra, one cool one temperature of pharmacological property, can opening lung-energy, be equipped with almond and Lung drops in dried orange peel, and lung is made to open and close degree of having, and goes up and down mechanism of qi, helps with tendril-leaved fritillary bulb cough-relieving resolving sputum clearing lung-heat, makes to have one's ideas straightened out with yellow wingceltis inducing resuscitation, Neng Gouzhi Cough resolving sputum, freeing lung and relieving asthma, inducing resuscitation is had one's ideas straightened out, removing heat from the lung and relieving sorethroat, can be used for that giddy caused by treating anemofrigid cold, head be heavy, cough, phlegm The symptoms such as more, lung's discomfort.In addition, the moistening lung composition plays the role of cleaning, sterilization, user's sucking to air after lighting Afterwards, also there is bactericidal effect to user individual, and does not will increase smog injury.
It should be understood that above general description and following detailed description be only it is exemplary and explanatory, not It can the limitation present invention.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality Applying example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.
The present invention provides a kind of moistening lung compositions, including following component:
Yellow wingceltis, peppermint, Chinese ephedra, almond, dried orange peel and tendril-leaved fritillary bulb.
Wherein, yellow wingceltis acrid flavour, hardship, row is flat, returns spleen, stomach, the heart, lung channel;Peppermint nature and flavor are pungent, cool, return lung, Liver Channel, evacuate wind Heat, head clearing, Breast bilges frowsty;Chinese ephedra nature and flavor are pungent, slight bitter, warm-natured.Return lung, bladder meridian.With sweating cold dispelling, freeing lung and relieving asthma, The function of inducing diuresis for removing edema;Almond is bitter in taste, tepor, slightly poisonous.Return lung, large intestine channel.Almond is used for relieving cough and asthma, relax bowel and defecation; Dried orange peel nature and flavor acrid, bitter, warm, enters spleen, lung channel.Dried orange peel contains volatile oil, glycosides displayed (such as orange degree glucoside), inositol, vitamin B1;Dried orange peel The effect of the irritant passive eliminating the phlegm of contained volatile oil, brings up sputum easily.Dried orange peel has faint dilating effect to bronchus, Its alcohol extract antiasthmatic effect is preferable;Tendril-leaved fritillary bulb, it is bitter in taste, sweet, it is slightly cold.Return lung, the heart channel of Hang-Shaoyin, clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, dissipating bind disappear Carbuncle.
In the present embodiment, peppermint, Chinese ephedra be monarch drug in a prescription, peppermint is cool in nature, and Chinese ephedra is warm-natured, one it is cool one temperature, can opening lung-energy, Almond, dried orange peel are ministerial drug, and almond cough-relieving is relievingd asthma, dried orange peel eliminating the phlegm, assist monarch drug in a prescription, and lung is made to open and close degree of having, and ventilate smooth, avoid cough It coughs and causes lung and excessively open and close, influence monarch drug in a prescription and play a role.Also, peppermint, two taste monarch drug in a prescription of Chinese ephedra have the function of rising lung, uplink Outward, almond, two taste ministerial drug of dried orange peel have the function of dropping lung, and downlink is inside, go up and down mechanism of qi, reach balance.Tendril-leaved fritillary bulb is adjutant, auxiliary Help the effect of dried orange peel enhancing resolving sputum.Yellow wingceltis has the function of eliminating dampness with aromatics, and can remove unclean gas, and inducing resuscitation is had one's ideas straightened out, refreshing clean air It is refreshing, sick institute is reached as making medicine guide other component drugs.
Moistening lung composition provided by the invention, by peppermint, Chinese ephedra opening lung-energy, almond, dried orange peel are relieving cough and asthma eliminating the phlegm, river Shellfish clearing heat and moistening lung, yellow wingceltis inducing resuscitation, can it is relieving cough and reducing sputum, freeing lung and relieving asthma, inducing resuscitation is had one's ideas straightened out, removing heat from the lung and relieving sorethroat, can be used for treating chill sense Emit the symptoms such as caused dizzy, head is heavy, cough, abundant expectoration, lung's discomfort.
In one preferred embodiment, moistening lung composition is grouped as by the group of following parts by weight:
8~15 parts of yellow wingceltis, 10~50 parts of peppermint, 10~50 parts of Chinese ephedra, 3~8 parts of almond, 10~50 parts of dried orange peel and tendril-leaved fritillary bulb 3 ~8 parts.
Wherein, yellow wingceltis for example can be 8 parts, 9 parts, 10 parts, 12 parts, 14 parts or 15 parts;Peppermint for example can be 10 parts, 20 Part, 25 parts, 30 parts, 35 parts, 40 parts or 50 parts;Chinese ephedra for example can be 10 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts or 50 Part;Almond for example can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts;Dried orange peel for example can for 10 parts, 20 parts, 30 parts, 40 parts or 50 parts;Tendril-leaved fritillary bulb for example can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts.
In a preferred embodiment, moistening lung composition is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Optionally, yellow wingceltis is yellow wingceltis powder.Optionally, yellow wingceltis powder is ground after removing the peel for the trunk of yellow wingceltis.Optionally, yellow The mesh number of wingceltis powder is 100~150 mesh.In this way, convenient for lighting and the active principle that volatilizees.
Optionally, peppermint is dried peppermint leaf or peppermint oil.Optionally, peppermint oil is peppermint stem, leaf is obtained by distillation mode. Peppermint oil generates refrigerant sense for skin or mucous membrane to mitigate uncomfortable and pain.
In one preferred embodiment, Chinese ephedra is that Chinese ephedra section plus ripe sweet frying form.Chinese ephedra section is what Chinese ephedra was cut into Section.Optionally, the step of Chinese ephedra section adds ripe sweet frying includes: to dilute ripe honey with boiled water, drenches in Chinese ephedra section and mixes thoroughly, bored profit, Set in frying container, heated with mild fire, fry to it is tack-free when, be down to room temperature, obtain Chinese ephedra.
Optionally, the mass ratio of Chinese ephedra section and ripe honey is 5:1.Specifically, every 100 ㎏ Chinese ephedra section, with ripe sweet 20 ㎏.It is optional Ground, when bored profit a length of 30min.In this way, preferable to the treatment effect of Chinese ephedra section.
Optionally, the volume ratio of ripe honey and boiled water is 3:1~4:1.In this way, ripe honey is enable sufficiently to infiltrate Chinese ephedra section.
Optionally, ripe honey is that honey is heated to 80~100 DEG C and obtains.In the present embodiment, ripe honey can enhance moistening lung and stop The effect of cough, and the pharmacological property of Chinese ephedra can be mitigated, the sweating effect of its Chinese ephedra is reduced, is conducive to relieving cough and asthma.Chinese ephedra section is with ripe After honey processing, warm-natured inclined profit, pungent scattered perspiration mitigates, with power victory of freeinging lung and relieving asthma.It is lighter to be chiefly used in exterior syndrome, and block of lung-QI,obstruction of lung-QI, The heavier patient of cough and asthma.
In one preferred embodiment, almond is that semen armeniacae amarae is placed in heating in boiling water to obtain.
The pre-treatment step of almond is as follows:
Semen armeniacae amarae is weeded out into scurf impurity, picks up net remaining nucleocapsid and brown elaioleucite;
Dan almond: taking net almond to set in 10 times of amount boiling water, heats about 5 minutes, until kind micro- swell of skin is pulled out, is soaked with cold water Bubble takes out, kind of skin and kernel is rubbed open, dry, weeds out kind of a skin and obtains almond.
Since semen armeniacae amarae is bitter in taste, tepor is slightly poisonous.Return lung, large intestine channel.It is relieving cough and asthma, relax bowel and defecation.Dan semen armeniacae amarae is made With identical as health product.After Dan peeling, non-medicinal effects are removed, it is fried conducive to effective component, improve drug effect.
The present invention also provides application of the above-mentioned moistening lung composition in the imbedibility drug of preparation moistening lung to arrest cough.
In one preferred embodiment, above-mentioned imbedibility drug is tobacco powder.
The present invention also provides a kind of tobacco powder, include above-mentioned moistening lung composition.Tobacco powder is a kind of powdery that can be lighted Product, when burning, generate flue gas.Flue gas can be generated after the tobacco powder is lighted, flue gas is spilt into air, and user's breathing is mixed with The air of flue gas, the effect of the moistening lung reached.This method allows medicament to directly act on lung.
The preparation method of tobacco powder includes: to mix each raw material for forming moistening lung composition and be ground into powdery.
In one preferred embodiment, each raw material is crushed to 80~100 mesh.
The present invention also provides the application methods of above-mentioned tobacco powder, comprising: lighting tobacco powder makes it generate flue gas, and user exhales Persorption has the air of flue gas.
The application method of above-mentioned tobacco powder provided by the invention, securely and reliably, convenient for grasping, and easy for patients to accept, curative effect Reliably, it is worthy of popularization.
In order to facilitate the clearer understanding present invention, below in conjunction with embodiment and comparative example to technical side of the invention Case is described further.
Embodiment 1
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
8 parts of yellow wingceltis, 30 parts of peppermint, 20 parts of Chinese ephedra, 3 parts of almond, 50 parts of dried orange peel and 3 parts of tendril-leaved fritillary bulb.
Embodiment 2
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
12 parts of yellow wingceltis, 20 parts of peppermint, 30 parts of Chinese ephedra, 3 parts of almond, 40 parts of dried orange peel and 3 parts of tendril-leaved fritillary bulb.
Embodiment 3
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Embodiment 4
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
8 parts of yellow wingceltis, 40 parts of peppermint, 50 parts of Chinese ephedra, 8 parts of almond, 10 parts of dried orange peel and 8 parts of tendril-leaved fritillary bulb.
Embodiment 5
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
15 parts of yellow wingceltis, 10 parts of peppermint, 10 parts of Chinese ephedra, 5 parts of almond, 10 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Comparative example 1
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of agalloch eaglewood, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Comparative example 2
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of wrinkled giant hyssop, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Comparative example 3
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of wrinkled giant hyssop, 30 parts of ramulus cinnamomi, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Comparative example 4
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of fritillaria thunbergii.
Comparative example 5
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of lepidium seed, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
Comparative example 6
A kind of moistening lung composition, is grouped as by the group of following parts by weight:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of lepidium seed, 40 parts of Exocarpium Citri Grandis and 5 parts of tendril-leaved fritillary bulb.
Embodiment 6
Ripe honey 10kg is diluted with boiled water, the volume ratio of ripe honey and boiled water is 3.5:1, drenches in 2kg Chinese ephedra section and mixes thoroughly, bored Moisten 30min, is subsequently placed in frying container, is heated with mild fire, frying 15min is down to room temperature, obtains Chinese ephedra.
Embodiment 7
Each raw material for forming moistening lung composition is mixed and be ground to 80~100 mesh, obtains tobacco powder.
By above-described embodiment 1~5, the moistening lung composition that comparative example 1~6 provides is prepared referring to the preparation method of embodiment 7 At tobacco powder, wherein Chinese ephedra is to be handled to obtain to Chinese ephedra section using the processing mode of embodiment 6.
In order to which the beneficial effect to moistening lung composition provided by the invention for moistening lung, cough-relieving is further detailed, Using tobacco powder made of above-mentioned each moistening lung composition, tested as follows:
The patient with anemofrigid cold to see and treat patients to clinic carries out routine examination, for wherein with cough, more phlegm, lung The patient of not moderate one or more symptoms selects 110 patients, and is randomly divided into 11 groups, respectively example 1 group, implementation 2 groups of example, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example, 4 groups of comparative example, 5 groups of comparative example, 6 groups of comparative example, every group of 10 people.
Treatment method:
Examples 1 to 5, comparative example 1~2, the Chinese ephedra in comparative example 4~6 are obtained using the method for embodiment 6, respectively will Examples 1 to 5, comparative example 1~6 prepare tobacco powder using the preparation method of embodiment 7, by the corresponding use of tobacco powder in embodiment 1 ~5 groups, in the patient that 1~6 group of comparative example, such as: the patient of example 1 group using the formula preparation of embodiment 1 tobacco powder, it is real Apply the tobacco powder ... and so on that 2 groups of example of patient is prepared using the formula of embodiment 2.
Application method: tobacco powder is lighted, and patient respiratory is mixed with the air of flue gas, three times a day, each 20min.
Criterion of therapeutical effect:
1. recovery from illness: cough stops, no phlegm, no asthma, and lung X-ray optical test is normal.
2. effective: cough stopping or accidental, sputum is accidental, no asthma, and lung X-ray optical test inflammation mitigates.
3. effectively: cough number is reduced, and sputum is reduced, accidental asthma, and lung X-ray optical test inflammation mitigates.
4. invalid: symptom is without improvement.
Total effective rate=(recovery from illness+effective+effectively)/gross efficiency × 100%.
Above-mentioned each group with 2 months be 1 course for the treatment of, continuously treat 1 course for the treatment of, after follow-up 1 month.
Clinical efficacy comparison the results are shown in Table 1:
1 each group Clinical efficacy comparison of table
Group Recovery from illness It is effective Effectively In vain Efficient (%)
Example 1 group 3 3 2 2 80
2 groups of embodiment 4 2 3 1 90
3 groups of embodiment 5 3 2 0 100
4 groups of embodiment 3 2 3 2 80
5 groups of embodiment 2 4 2 1 80
1 group of comparative example 1 2 4 3 70
2 groups of comparative example 2 1 1 6 40
3 groups of comparative example 1 0 3 6 40
4 groups of comparative example 0 2 3 5 50
5 groups of comparative example 1 1 4 4 60
6 groups of comparative example 2 1 3 4 60
As can be seen that the average effectiveness level of embodiment group is 86% from the result of table 1, the average effectiveness level of comparative example group It is 53%, the effective percentage of each group in embodiment group is above the effective percentage of each group in comparative example.Wherein, embodiment 3 provides Moistening lung composition therapeutic effect it is best, effective percentage reaches 100%, illustrate the embodiment of the present invention 3 provide moistening lung composition By specific component and specific proportion combination, cough can be effectively treated, there are the symptom of inflammation in more phlegm, lung.
The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;Although referring to aforementioned each reality Applying example, invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each Technical solution documented by embodiment is modified, or equivalent substitution of some or all of the technical features;And These are modified or replaceed, the range for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.

Claims (10)

1. a kind of moistening lung composition, which is characterized in that the moistening lung composition includes following component:
Yellow wingceltis, peppermint, Chinese ephedra, almond, dried orange peel and tendril-leaved fritillary bulb.
2. moistening lung composition according to claim 1, which is characterized in that the moistening lung composition by following parts by weight group It is grouped as:
8~15 parts of yellow wingceltis, 10~50 parts of peppermint, 10~50 parts of Chinese ephedra, 3~8 parts of almond, 10~50 parts of dried orange peel and tendril-leaved fritillary bulb 3~8 Part.
3. moistening lung composition according to claim 2, which is characterized in that the moistening lung composition by following parts by weight group It is grouped as:
10 parts of yellow wingceltis, 30 parts of peppermint, 30 parts of Chinese ephedra, 5 parts of almond, 40 parts of dried orange peel and 5 parts of tendril-leaved fritillary bulb.
4. moistening lung composition according to claim 1, which is characterized in that the peppermint is dried peppermint leaf or peppermint oil.
5. moistening lung composition according to claim 1, which is characterized in that the Chinese ephedra be Chinese ephedra section plus ripe sweet frying and At.
6. moistening lung composition according to claim 1, which is characterized in that the almond is to be placed in semen armeniacae amarae in boiling water to add Heat obtains.
7. application of the moistening lung composition as described in any one of claims 1 to 6 in the imbedibility drug of preparation moistening lung to arrest cough.
8. application according to claim 7, which is characterized in that the imbedibility drug is tobacco powder.
9. a kind of tobacco powder, which is characterized in that comprising such as moistening lung composition according to any one of claims 1 to 6.
10. a kind of application method of tobacco powder characterized by comprising lighting tobacco powder as claimed in claim 9 makes its generation Flue gas, user breathe the air for being mixed with flue gas.
CN201811431408.9A 2018-11-26 2018-11-26 A kind of moistening lung composition and application, tobacco powder and application method Pending CN109276640A (en)

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CN102579785A (en) * 2012-02-28 2012-07-18 郭纯 Lung caring pill
CN106418681A (en) * 2010-11-10 2017-02-22 高思 Herbal natural-fragrance compound functional cigarette capable of nourishing lung, arresting cough, eliminating phlegm and relieving asthma
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CN106418681A (en) * 2010-11-10 2017-02-22 高思 Herbal natural-fragrance compound functional cigarette capable of nourishing lung, arresting cough, eliminating phlegm and relieving asthma
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Application publication date: 20190129