CN109264812A - One kind is for removing endotoxic method in glucidtemns - Google Patents
One kind is for removing endotoxic method in glucidtemns Download PDFInfo
- Publication number
- CN109264812A CN109264812A CN201811348653.3A CN201811348653A CN109264812A CN 109264812 A CN109264812 A CN 109264812A CN 201811348653 A CN201811348653 A CN 201811348653A CN 109264812 A CN109264812 A CN 109264812A
- Authority
- CN
- China
- Prior art keywords
- glucidtemns
- active carbon
- solution
- endotoxin
- heated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/28—Treatment of water, waste water, or sewage by sorption
- C02F1/281—Treatment of water, waste water, or sewage by sorption using inorganic sorbents
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2101/00—Nature of the contaminant
- C02F2101/10—Inorganic compounds
- C02F2101/20—Heavy metals or heavy metal compounds
Abstract
The present invention provides one kind for removing endotoxic method in glucidtemns, its main feature is that: include the following steps: that (1) active carbon is scattered in 5 times or more water, hydrochloric acid conditioning solution pH is added between 1.0 ~ 3.0,60 DEG C or more are heated to, 0.5 ~ 2h, filtering are stirred, washing, is filtered dry；(2) processed active carbon is put into glucidtemns solution, is heated to 90 DEG C or more, stirring 0.5 ~ 1h of heat preservation discharges the hydrogen chloride adsorbed during processing by active carbon, pH value of solution is made to reach 3.0 ~ 4.0；(3) then glucidtemns aqueous solution is obtained, glucidtemns aqueous solution is spray-dried by filtering, obtain starch hydrolysate solids.Its endotoxin content is set to reach the level of pharmacopoeial requirements.
Description
Technical field
The invention belongs to medicinal chemicals to synthesize field, specifically a kind of endotoxic in glucidtemns for removing
Method.
Background technique
Peritoneal dialysis (PD) be using the peritonaeum of patient as semi-permeable membrane, to intraperitoneal injection peritoneal dialysis liquid, by blood plasma with
Solute concentration gradient between peritoneal dialysis liquid is removed under normal circumstances as caused by nitrogen metabolism and kidney excretion with osmotic gradient
Noxious material, and help to adjust body fluid, electrolyte and the acid-base balance in body, whole end stage renal is treated as a kind of
The method of sick (end stage renal disease, ESRD) patient, it is easy to operate since its house is treated, reduce haematogenous
Transmission, the special advantages such as protection residual renal function, has been widely used in recent years.
Using glucose as bleeding agent, glucose has many advantages, such as to be easy acquirement as bleeding agent, cheap.But it is traditional
Peritoneal dialysis solution is many in high sugar, high glucose catabolite (GDPs), high-glycosylation dead end product (AGEs) and low ph value etc.
Aspect can have an adverse effect to patient, can lead to peritoneal fibrosiss after long-time use and ultrafiltration volume is reduced, be the saturating patient of abdomen
The main reason for exiting PD treatment.In addition, glucose molecule size is small, glucose is transported by rapidly peritonaeum, thus about 2
Into injections in 4 hours, lead to the loss of loss and the ultrafiltration of osmotic gradient.Therefore, glucose is not a kind of ideal infiltration
Agent needs other bleeding agents and comes instead.
Glucose polymer is macromolecular polymeric body, and molecular volume is big, directly can not pass through peritoneal wall via diffusion
Capilary is absorbed by body in into peritonaeum, therefore, in generating high colloid osmotic pressure in cavum peritoneale, to maintain the indwelling phase de-
Water and efficiency is cleaned up, meanwhile, multinomial clinical benefit is also provided: promoting the long ultrafiltration effect of patients undergoing peritoneal dialysis, improves peritoneal dialysis
Patient body fluid balance；The carbohydrate that the every Nikkei peritoneal dialysis solution of patient absorbs is reduced, patients with lipid's disease risks are reduced；Delay patient
The forfeiture of ultrafiltration efficiency extends the saturating age of patients undergoing peritoneal dialysis.
This kind of glucose polymer is all the shallow lake for obtaining specified molecular weight by sour water solution or enzymatic hydrolysis by starch
Powder hydrolysate, such as Icodextrin.However it is used for the preparation of peritoneal dialysis, microbial contamination wants strict control.But it reflects
In the starting material cornstarch etc. for preparing these glucidtemns, microbial contamination is to be unable to control, microbial contamination
Caused by bacteria endotoxin content it is very high.Endotoxin is the cell wall constituent of a variety of Gram-negative bacterias, after cellular lysate
The toxin released, also referred to as " pyrogen ".Endotoxin can cause fever, microcirculation disorder, endotoxin shock and disseminated intravascular
Intravascular coagulation etc..Using the peritoneal dialysis solution of the underproof bulk pharmaceutical chemicals preparation of endotoxin, peritonitis is easily caused, therefore for peritonaeum
Dialysis class pharmaceutical preparation has to completely remove endotoxin.
Medical industry removes the active carbon decoloring of endotoxic main method, adsorption filtration, enzyme edman degradation Edman, ion friendship at present
Change resin adsorption method, ultrafiltration etc..
Adsorption filtration is mainly to make feed liquid by positively charged Filters, to adsorb positively charged endotoxin and reach
To purpose, such method can only remove a certain amount of endotoxin, if contained in feed liquid, endotoxin amount is larger not to be can be removed completely.
And filter core is disposable, higher cost, compares and is suitble to use in the less preparation terminal of endotoxin content.
Enzyme edman degradation Edman is by the way that active enzyme component is added into the solution containing bulk pharmaceutical chemicals, such as patent CN103228678B
In the rill wall that gram- bacteria is decomposed using lysozyme and laminarinase mentioned, reach the endotoxic effect of bacterium for degrading
Fruit.But for drug, these degrading enzymes inherently pollutant, it is subsequent will also be to remove these pollutants and effort.
It is negatively charged that ion exchange resin absorption endotoxin, which is using endotoxin, reaches absorption by ion exchange
Effect, Baxter company describe such method in its patent WO2009/117302.But such method can only adsorption section
Divide endotoxin that can not meet the requirements completely greatly increasing the amount of ion exchange resin when endotoxin content is larger.This
Mainly due to endotoxin is although negatively charged, but since molecule is larger, electrically weaker, the endotoxin for causing molecular weight big can not
It is adsorbed.
Ultrafiltration is to realize endotoxic removal by the retention of different molecular weight.Such method can only be suitble to product point
Son amount is larger with endotoxin difference, and glucidtemns such as Icodextrin molecular weight ranges are between 2K ~ 80K, just include interior
The molecular weight of toxin, therefore such method can not remove endotoxic conventional method as glucidtemns.
Active carbon adsorption is the endotoxic method of most conventional removal, generallys use activity in bulk pharmaceutical chemicals and preparation terminal
The mode of charcoal absorption carries out the endotoxic control of product.But when carrying out decoloration related experiment to glucidtemns, discovery is worked as
When the dosage of active carbon reaches 30%, the endotoxin in feed liquid is still significantly exceeded, and when endotoxin is reduced to certain level, living
Property charcoal absorption almost do not work, endotoxin keeps horizontal almost unchanged herein, and endotoxic content is still significantly super at this time
Mark.
European Pharmacopoeia peritoneal dialysis liquid quality criteria requirements endotoxin content is lower than 0.05EU/ml, by taking Icodextrin as an example, 1L Chinese mugwort
75g containing Icodextrin in dextrin peritoneal dialysis liquid is examined, the endotoxin content that conversion can obtain Icodextrin bulk pharmaceutical chemicals has to be lower than 0.67EU/
g。
Find that for the endotoxin content of glucidtemns in 100EU/g, content is very big by detection.Aforementioned removal endogenous toxic material
The method of element, can not all make product endotoxin reach an acceptable level.
Therefore, for glucidtemns such as Icodextrin such as glucan compound, how to design a kind of for removing
Endotoxic method in glucidtemns enables its endotoxin content to reach European medicine by optimizing current discoloration method
The level that allusion quotation requires.This is this field technical problem urgently to be resolved.
Summary of the invention
The present invention in order to solve the problems existing in the prior art, provides a kind of for removing endotoxic side in glucidtemns
Method enables its endotoxin content to reach the level of European Pharmacopoeia requirement.
The purpose of the present invention is what is be achieved through the following technical solutions: one kind is endotoxic in glucidtemns for removing
Method, it is characterised in that, include the following steps:
(1) active carbon is scattered in 5 times or more water, be added hydrochloric acid conditioning solution pH between 1.0 ~ 3.0, be heated to 60 DEG C with
On, 0.5 ~ 2h is stirred, is filtered, washing is filtered dry；
(2) processed active carbon is put into glucidtemns solution, is heated to 90 DEG C or more, stirring 0.5 ~ 1h of heat preservation leads to
It crosses active carbon and discharges the hydrogen chloride adsorbed during processing, so that pH value of solution is reached 3.0 ~ 4.0, with this condition, can enhance
The adsorption capacity of active carbon, and be unlikely to keep products molecule because the reduction of acidity causes the secondary hydrolysis of glucidtemns
It measures constant；
(3) then glucidtemns aqueous solution is obtained, glucidtemns aqueous solution is spray-dried by filtering, obtain starch
Hydrolysate solids.
Improvement to above-mentioned technical proposal: the glucidtemns of the step (2) is Icodextrin.
Further improvement to above-mentioned technical proposal: in the step (1), the pH is 1.0, mixing time 1h；
Further improvement to above-mentioned technical proposal: in the step (2), stirring soaking time is 1h, and the pH is 3.5.
The present invention has the following advantages that compared with prior art and good effect:
1, the endotoxic method of removal provided by the present invention, implementation condition requirement is low, need to only heat reaction kettle and centrifuge
Equal filter plants, almost all of production line can all carry out, easy to operate, low to personnel requirement, easy to promote and utilize.
2, cost of the invention is extremely low, and using a small amount of active carbon, a small amount of hydrochloric acid can greatly improve the suction of active carbon
Attached efficiency, compared to using such as the methods of absorption, cost is very little.As: the cornstarch hydrolysate of 100kg is using 3kg
Active carbon decolourizes, product endotoxin content < 0.1EU/g.Its content is well below the saturating standard of European abdomen.
3, by detection discovery, a large amount of metal ions are contained in active carbon, if magnesium ion reaches 100ug/g or more, aluminium from
Son reaches 50ug/g or more, and there are also zinc ions, including heavy metal ion, and the pretreatment of active carbon through the invention pair, no
Only substantially increase the adsorption activity of active carbon, and eliminate the above-mentioned metal ion etc. for including in active carbon, make its with
In the contact process of feed liquid, the almost release of non-metallic ion.
Specific embodiment
The present invention is a kind of for removing the embodiment of endotoxic method in glucidtemns, includes the following steps:
(1) active carbon is scattered in 5 times or more water, be added hydrochloric acid conditioning solution pH between 1.0 ~ 3.0, be heated to 60 DEG C with
On, 0.5 ~ 2h is stirred, is filtered, washing is filtered dry；
(2) processed active carbon is put into glucidtemns solution, is heated to 90 DEG C or more, stirring 0.5 ~ 1h of heat preservation leads to
It crosses active carbon and discharges the hydrogen chloride adsorbed during processing, so that pH value of solution is reached 3.0 ~ 4.0, with this condition, can enhance
The adsorption capacity of active carbon, and be unlikely to keep products molecule because the reduction of acidity causes the secondary hydrolysis of glucidtemns
It measures constant.
(3) then glucidtemns aqueous solution is obtained, glucidtemns aqueous solution is spray-dried by filtering, obtained
Starch hydrolysate solids.The solid endotoxin content of survey is lower than 0.1EU/g, and content is well below the saturating standard of European abdomen.
Further, the glucidtemns in above-mentioned steps (2) is such as Icodextrin or hydroxyethyl starch.
The following are the present invention is a kind of for removing several specific embodiments of endotoxic method in glucidtemns:
The present invention is a kind of for removing the embodiment 1 of endotoxic method in glucidtemns:
Purified water 30L, active carbon 3kg are added in 50L reaction kettle, salt acid for adjusting pH is added to 1.5, opens heating, is heated to 60
DEG C, insulated and stirred 1h.It is filtered under diminished pressure, obtains Pre-Treatment of Activated charcoal.
Pretreated active carbon is added in Icodextrin feed liquid (Icodextrin containing 200kg in about 1200L feed liquid), heating
It to 90 DEG C or more, is filtered after keeping the temperature 0.5h, gel method detects filtrate, and endotoxin content is lower than 0.06Eu/ml.
The present invention is a kind of for removing the embodiment 2 of endotoxic method in glucidtemns:
Purified water 30L, active carbon 3kg are added in 50L reaction kettle, salt acid for adjusting pH is added to 1.0, opens heating, is heated to 60
DEG C, insulated and stirred 1h.It is filtered under diminished pressure, obtains Pre-Treatment of Activated charcoal.
Pretreated active carbon is added in Icodextrin feed liquid (Icodextrin containing 200kg in about 1200L feed liquid), heating
It to 90 DEG C, is filtered after keeping the temperature 0.5h, gel method detects filtrate, and endotoxin content is lower than 0.06Eu/ml.
The present invention is a kind of for removing the embodiment 3 of endotoxic method in glucidtemns:
Purified water 30L, active carbon 3kg are added in 50L reaction kettle, salt acid for adjusting pH is added to 3.0, opens heating, is heated to 60
DEG C, insulated and stirred 1h.It is filtered under diminished pressure, obtains Pre-Treatment of Activated charcoal.
Pretreated active carbon is added in Icodextrin feed liquid (Icodextrin containing 200kg in about 1200L feed liquid), heating
It to 90 DEG C, is filtered after keeping the temperature 0.5h, gel method detects filtrate, and endotoxin content is lower than 0.06Eu/ml.
The present invention is a kind of for removing the embodiment 4 of endotoxic method in glucidtemns:
Purified water 15L, active carbon 3kg are added in 50L reaction kettle, salt acid for adjusting pH is added to 1.5, opens heating, is heated to 60
DEG C, insulated and stirred 1h.It is filtered under diminished pressure, obtains Pre-Treatment of Activated charcoal.
Pretreated active carbon is added in Icodextrin feed liquid (Icodextrin containing 200kg in about 1200L feed liquid), heating
It to 90 DEG C, is filtered after keeping the temperature 0.5h, gel method detects filtrate, and endotoxin content is lower than 0.06Eu/ml.
Certainly, above description is not the limitation to invention, and the present invention is also not limited to the example above, the art
Those of ordinary skill, the variations, modifications, additions or substitutions made within the essential scope of the present invention also should belong to of the invention
Protection scope.
Claims (5)
1. one kind is for removing endotoxic method in glucidtemns, it is characterised in that, include the following steps:
(1) active carbon is scattered in 5 times or more water, be added hydrochloric acid conditioning solution pH between 1.0 ~ 3.0, be heated to 60 DEG C with
On, 0.5 ~ 2h is stirred, is filtered, washing is filtered dry；
(2) processed active carbon is put into glucidtemns solution, is heated to 90 DEG C or more, stirring 0.5 ~ 1h of heat preservation leads to
It crosses active carbon and discharges the hydrogen chloride adsorbed during processing, pH value of solution is made to reach 3.0 ~ 4.0；
(3) then glucidtemns aqueous solution is obtained, glucidtemns aqueous solution is spray-dried by filtering, obtain starch
Hydrolysate solids.
2. described in accordance with the claim 1 for removing endotoxic method in glucidtemns, which is characterized in that the step
(2) glucidtemns is Icodextrin.
3. according to claim 1 or 2 for removing endotoxic method in glucidtemns, which is characterized in that described
In step (1), the pH is 1.0, mixing time 1h.
4. according to claim 1 or 2 for removing endotoxic method in glucidtemns, which is characterized in that described
In step (2), stirring soaking time is 1h, and the pH is 3.5.
5. described in accordance with the claim 3 for removing endotoxic method in glucidtemns, which is characterized in that the step
(2) in, stirring soaking time is 1h, and the pH is 3.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811348653.3A CN109264812A (en) | 2018-11-13 | 2018-11-13 | One kind is for removing endotoxic method in glucidtemns |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811348653.3A CN109264812A (en) | 2018-11-13 | 2018-11-13 | One kind is for removing endotoxic method in glucidtemns |
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| CN109264812A true CN109264812A (en) | 2019-01-25 |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1918302A (en) * | 2004-02-27 | 2007-02-21 | 巴克斯特国际公司 | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
| CN102659953A (en) * | 2012-04-18 | 2012-09-12 | 高旭 | Preparation method of hydroxyethyl starch with molecular weight of 5,500,000 |
| CN102911276A (en) * | 2011-08-03 | 2013-02-06 | 四川科伦药业股份有限公司 | Method for treating endotoxin in hydroxyethyl starch |
| CN103228678A (en) * | 2010-11-03 | 2013-07-31 | 罗盖特兄弟公司 | Method for decontaminating starch hydrolysates for the preparation of glucose polymers for peritoneal dialysis |
| CN103864942A (en) * | 2012-12-11 | 2014-06-18 | 北大方正集团有限公司 | Medium molecular weight hydroxyethyl starch and its purifying method |
| CN105131135A (en) * | 2015-09-17 | 2015-12-09 | 成都博佳制药有限公司 | Industrial production method of icodextrin |
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| CN1918302A (en) * | 2004-02-27 | 2007-02-21 | 巴克斯特国际公司 | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
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| CN105131135A (en) * | 2015-09-17 | 2015-12-09 | 成都博佳制药有限公司 | Industrial production method of icodextrin |
| CN106632721A (en) * | 2015-11-03 | 2017-05-10 | 华仁药业股份有限公司 | Glucose polymer, and preparation method and applications thereof |
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