CN109260360A - A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof - Google Patents
A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof Download PDFInfo
- Publication number
- CN109260360A CN109260360A CN201811454694.0A CN201811454694A CN109260360A CN 109260360 A CN109260360 A CN 109260360A CN 201811454694 A CN201811454694 A CN 201811454694A CN 109260360 A CN109260360 A CN 109260360A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- bacterio static
- static itching
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of bacterio static itching-relieving traditional Chinese medicine gels, are made of raw material from the following weight: 60~100 parts of wormwood, 85~125 parts of climbing groundsel, 85~125 parts of grandmother's fourth, 65~95 parts of Herba Lespedezae Cuneatae, 65~95 parts of lineate supplejack leaf, 45~85 parts of euphorbia fischeriana, 40~80 parts of mock-strawberry, 40~80 parts of Prunella vulgaris, 20~60 parts of Rhizoma Atractylodis Macrocephalae, 25~65 parts of wrinkled giant hyssop, 35~75 parts of Asiatic plantain, 35~75 parts of butterflybush flower, 35~75 parts of pipewort, 70~100 parts of purslane, 10~40 parts of rhizoma anemarrhenae.The raw materials used present invention is natural Chinese medicinal herbs, it is mainly used for the dermatological conditions such as pruitus, has the function of antibacterial, antipruritic, clearing damp, without any toxicity and side effects, and action time is short, quick, good effect, various skin diseases can be eradicated, the administration time that will not repeatedly, overcome current Chinese herbal medicine for external use object antipruritic on the market is longer, is difficult to the disadvantages of eradicating.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation more particularly to a kind of bacterio static itching-relieving traditional Chinese medicine gel and its preparation sides
Method.
Background technique
Come under hygrothermal environment, due to largely perspiring, continuous skin is impregnated by sweat, easily generation skin disease, as furuncle kind,
Tinea, prickly heat, scrotitis and eczema etc., this can cause pruitus.Almost everyone has the experience of pruitus, causes skin
The reason of skin itch, is very more, common to see that reason has itch caused by chafing, drying, infection or intrinsic disease, in addition, gas
Waiting influences as hot, moist, cold, dry, and pruitus caused by the unknown causes such as bite by mosquitos, allergy also usually annoyings
People.Although pruitus is indisposition, can itch tangible disquieting meaning disorderly, fidgety, in addition allow people's pain not
Bear.
The conventional therapies of active dermatological disease are: after clarifying a diagnosis, selecting corresponding anti-bacterial, anti-itching drug (such as chlorpheniramine, skin
Easily, prednisone), or add antimycotic (such as clotrimazole, ketoconazole), anti-infective (such as tetracycline, penicillin) drug therapy.This
1. the main problems are as follows: that sample is done diagnoses is difficult to define, it is difficult to accomplish accurately to select drug；2. pharmic function is single, application
Narrow scope.As antifungal drug does not have antibacterial actions.Anti-bacterial drug does not have antifungic action；3. drug side-effect is bright
It is aobvious.Antipruritic such as oral administration often has apparent drowsiness effect, and prolonged application hormone can cause skin resistance to decline；4. drug resistance is gradually
It improves, curative effect does not write.Due to the extensive use of hormone, antibiotic preparation, practical due drug effect is not reflected, and is often made
At helpless situation.
Doctor trained in Western medicine thinks pruitus and several media such as histamine, serotonin, Endogenous opioid peptide system, cell factor
Deng participation it is related, generally give that antihistamine is for oral administration or hormone medicine external application at present, but often have drowsiness and atrophoderma, office
The side effects such as portion's cutaneous pigmentation, telangiectasis, Mao Xiangyan, habituation.Chinese medicine then thinks pruitus with internal heat and lung
The related therefore clearing heat and detoxicating Chinese medicine of heat is the common medicine for treating pruitus.It is remote that traditional Chinese medicine Topical therapy treats skin pathogeny
Stream length, curative effect is reliable, in thousands of years of development, has accumulated a large amount of recipe name medicine.Clinic shows that Chinese medicine has many Western medicine
Incomparable advantage, such as wide indications, few side effects, drug resistance is low, comprehensive drug is prominent.But it is existing at present most
Number Chinese herbal medicine is all to take effect relatively slowly, needs administration time longer, and be also difficult to eradicate, and is easy repeatedly.
Therefore, it is particularly important to develop a kind of quick bacterio static itching-relieving traditional Chinese medicine gel.
Summary of the invention
The present invention is in order to solve the above technical problems, provide a kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof.This
Inventing raw materials used is natural Chinese medicinal herb, and gelling agent is prepared at a lower temperature, is mainly used for the skins such as pruitus
Skin disease symptoms have the function of antibacterial, antipruritic, clearing damp, without any toxicity and side effects, easy to use, skin good absorbing when use, oil-free
The senses of discomfort such as greasy, and action time is short, quick, good effect, can eradicate various skin diseases, will not overcome at present repeatedly
The administration time of antipruritic Chinese herbal medicine for external use object is longer on the market, the disadvantages of skin greasing is uncomfortable is felt when being difficult to eradicate, use.
In order to reach purpose described above, the invention adopts the following technical scheme:
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 60~100 parts of wormwood, climbing groundsel 85
~125 parts, 85~125 parts of grandmother's fourth, 65~95 parts of Herba Lespedezae Cuneatae, 65~95 parts of lineate supplejack leaf, 45~85 parts of euphorbia fischeriana, mock-strawberry 40
~80 parts, 40~80 parts of Prunella vulgaris, 20~60 parts of Rhizoma Atractylodis Macrocephalae, 25~65 parts of wrinkled giant hyssop, 35~75 parts of Asiatic plantain, butterflybush flower 35~75
Part, 35~75 parts of pipewort, 70~100 parts of purslane, 10~40 parts of rhizoma anemarrhenae.
Further, a kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: wormwood 70~
90 parts, 95~115 parts of climbing groundsel, 95~115 parts of grandmother's fourth, 75~85 parts of Herba Lespedezae Cuneatae, 75~85 parts of lineate supplejack leaf, euphorbia fischeriana 55
~75 parts, 50~70 parts of mock-strawberry, 50~70 parts of Prunella vulgaris, 30~50 parts of Rhizoma Atractylodis Macrocephalae, 35~55 parts of wrinkled giant hyssop, 45~65 parts of Asiatic plantain,
45~65 parts of butterflybush flower, 45~65 parts of pipewort, 80~90 parts of purslane, 20~30 parts of rhizoma anemarrhenae.
Further, a kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: wormwood 80
Part, 105 parts of climbing groundsel, 105 parts of grandmother's fourth, 80 parts of Herba Lespedezae Cuneatae, 80 parts of lineate supplejack leaf, 65 parts of euphorbia fischeriana, 60 parts of mock-strawberry, Prunella vulgaris
60 parts, 40 parts of Rhizoma Atractylodis Macrocephalae, 45 parts of wrinkled giant hyssop, 55 parts of Asiatic plantain, 55 parts of butterflybush flower, 55 parts of pipewort, 85 parts of purslane, 25 parts of rhizoma anemarrhenae.
Further, a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel as described above, comprising the following steps:
(1) wormwood, Po Poding, mock-strawberry, Prunella vulgaris, Rhizoma Atractylodis Macrocephalae, Asiatic plantain, butterflybush flower, pipewort are weighed according to parts by weight
And 5~6 times of wormwood weight of clear water, refluxing extraction 4 is added after pulverizer was crushed to 10~30 meshes, drying in purslane
~6h, natural filtration obtain filtrate and filter residue；
(2) climbing groundsel, Herba Lespedezae Cuneatae, lineate supplejack leaf, euphorbia fischeriana, wrinkled giant hyssop and rhizoma anemarrhenae are weighed according to parts by weight, are added after cleaning
Enter 2~3 times of climbing groundsel weight of boiled water, constant temperature impregnates, and ultrasonication, decompression filters, and residue and the filter residue that step (1) obtains are mixed
It closes uniformly, is sent into micronizer and is ground, then the boiled water of 4~5 times of climbing groundsel weight of addition, 3~4h of refluxing extraction,
Decompression filters, and merges filtrate twice, and the Aqueous extracts for being 1.0~1.3 to relative density are concentrated under reduced pressure；
(3) filtrate of step (1) is uniformly mixed with step (2) Aqueous extracts, centrifugation slagging-off, then carry out it is filling, be made
The bacterio static itching-relieving traditional Chinese medicine gel.
Further, in step (1), the drying is by dry materials to water content lower than 50%；The refluxing extraction
Temperature be 65~70 DEG C.
Further, in step (2), the temperature that the constant temperature impregnates is 70~80 DEG C, and the time is 8~10h.
Further, in step (2), the frequency of the ultrasonication is 0.1~0.3MHz, and power is 300~350W,
Time is 20~25min.
Further, in step (2), the pressure of the grinding is 0.2~0.3MPa, and temperature is 50~55 DEG C, by material
Being crushed to particle diameter size is 10~20 μm.
Further, in step (2), the temperature of the refluxing extraction is 60~70 DEG C；The temperature of the reduced pressure is
70~75 DEG C, pressure is 200~300Pa.
Further, in step (3), the revolving speed of the centrifugation is 2800~3300rpm, and the time is 10~20min.
Since present invention employs above technical schemes, have the advantages that
The raw materials used present invention is natural Chinese medicinal herbs, and gelling agent is prepared at a lower temperature, are mainly used for skin
The dermatological conditions such as skin itch have the function of antibacterial, antipruritic, clearing damp, without any toxicity and side effects, easy to use, skin when use
Good absorbing, without the senses of discomfort such as greasy, and action time is short, quick, good effect, can eradicate various skin diseases, will not repeatedly,
The administration time for overcoming current Chinese herbal medicine for external use object antipruritic on the market is longer, feeling skin greasing is not when being difficult to eradicate, use
The disadvantages of comfortable.
Specific embodiment
Specific embodiments of the present invention will be described in further detail below, but the invention is not limited to these realities
Mode is applied, it is claimed to still fall within the claims in the present invention for any improvement or replacement on the present embodiment essence spirit
Range.
Embodiment 1
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 60 parts of wormwood, 85 parts of climbing groundsel, mother-in-law
85 parts of mother-in-law's fourth, 65 parts of Herba Lespedezae Cuneatae, 65 parts of lineate supplejack leaf, 45 parts of euphorbia fischeriana, 40 parts of mock-strawberry, 40 parts of Prunella vulgaris, 20 parts of Rhizoma Atractylodis Macrocephalae, wrinkled giant hyssop
25 parts, 35 parts of Asiatic plantain, 35 parts of butterflybush flower, 35 parts of pipewort, 70 parts of purslane, 10 parts of rhizoma anemarrhenae.
A kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel as described above, comprising the following steps:
(1) wormwood, Po Poding, mock-strawberry, Prunella vulgaris, Rhizoma Atractylodis Macrocephalae, Asiatic plantain, butterflybush flower, pipewort are weighed according to parts by weight
And 5~6 times of wormwood weight of clear water, refluxing extraction 4 is added after pulverizer was crushed to 10~30 meshes, drying in purslane
~6h, natural filtration obtain filtrate and filter residue；The drying is by dry materials to water content lower than 50%；The refluxing extraction
Temperature be 65~70 DEG C；
(2) climbing groundsel, Herba Lespedezae Cuneatae, lineate supplejack leaf, euphorbia fischeriana, wrinkled giant hyssop and rhizoma anemarrhenae are weighed according to parts by weight, are added after cleaning
Enter 2~3 times of climbing groundsel weight of boiled water, constant temperature impregnates, and ultrasonication, decompression filters, and residue and the filter residue that step (1) obtains are mixed
It closes uniformly, is sent into micronizer and is ground, then the boiled water of 4~5 times of climbing groundsel weight of addition, 3~4h of refluxing extraction,
Decompression filters, and merges filtrate twice, and the Aqueous extracts for being 1.0~1.3 to relative density are concentrated under reduced pressure；
The temperature that the constant temperature impregnates is 70~80 DEG C, and the time is 8~10h；The frequency of the ultrasonication be 0.1~
0.3MHz, power are 300~350W, and the time is 20~25min；The pressure of the grinding be 0.2~0.3MPa, temperature be 50~
55 DEG C, be 10~20 μm by crushing material to particle diameter size；The temperature of the refluxing extraction is 60~70 DEG C；The decompression
The temperature of concentration is 70~75 DEG C, and pressure is 200~300Pa；
(3) filtrate of step (1) is uniformly mixed with step (2) Aqueous extracts, centrifugation slagging-off, then carry out it is filling, be made
The bacterio static itching-relieving traditional Chinese medicine gel；The revolving speed of the centrifugation is 2800~3300rpm, and the time is 10~20min.
Embodiment 2
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 100 parts of wormwood, 125 parts of climbing groundsel,
125 parts of grandmother's fourth, 95 parts of Herba Lespedezae Cuneatae, 95 parts of lineate supplejack leaf, 85 parts of euphorbia fischeriana, 80 parts of mock-strawberry, 80 parts of Prunella vulgaris, 60 parts of Rhizoma Atractylodis Macrocephalae,
65 parts of wrinkled giant hyssop, 75 parts of Asiatic plantain, 75 parts of butterflybush flower, 75 parts of pipewort, 100 parts of purslane, 40 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Embodiment 3
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 70 parts of wormwood, 95 parts of climbing groundsel, mother-in-law
95 parts of mother-in-law's fourth, 75 parts of Herba Lespedezae Cuneatae, 75 parts of lineate supplejack leaf, 55 parts of euphorbia fischeriana, 50 parts of mock-strawberry, 50 parts of Prunella vulgaris, 30 parts of Rhizoma Atractylodis Macrocephalae, wrinkled giant hyssop
35 parts, 45 parts of Asiatic plantain, 45 parts of butterflybush flower, 45 parts of pipewort, 80 parts of purslane, 20 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Embodiment 4
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 90 parts of wormwood, 115 parts of climbing groundsel, mother-in-law
115 parts of mother-in-law's fourth, 85 parts of Herba Lespedezae Cuneatae, 85 parts of lineate supplejack leaf, 75 parts of euphorbia fischeriana, 70 parts of mock-strawberry, 70 parts of Prunella vulgaris, 50 parts of Rhizoma Atractylodis Macrocephalae, the leaves of pulse plants
Fragrant 55 parts, 65 parts of Asiatic plantain, 65 parts of butterflybush flower, 65 parts of pipewort, 90 parts of purslane, 30 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Embodiment 5
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 80 parts of wormwood, 105 parts of climbing groundsel, mother-in-law
105 parts of mother-in-law's fourth, 80 parts of Herba Lespedezae Cuneatae, 80 parts of lineate supplejack leaf, 65 parts of euphorbia fischeriana, 60 parts of mock-strawberry, 60 parts of Prunella vulgaris, 40 parts of Rhizoma Atractylodis Macrocephalae, the leaves of pulse plants
Fragrant 45 parts, 55 parts of Asiatic plantain, 55 parts of butterflybush flower, 55 parts of pipewort, 85 parts of purslane, 25 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Embodiment 6
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 65 parts of wormwood, 90 parts of climbing groundsel, mother-in-law
90 parts of mother-in-law's fourth, 70 parts of Herba Lespedezae Cuneatae, 70 parts of lineate supplejack leaf, 50 parts of euphorbia fischeriana, 45 parts of mock-strawberry, 45 parts of Prunella vulgaris, 25 parts of Rhizoma Atractylodis Macrocephalae, wrinkled giant hyssop
30 parts, 40 parts of Asiatic plantain, 40 parts of butterflybush flower, 40 parts of pipewort, 75 parts of purslane, 15 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Embodiment 7
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 95 parts of wormwood, 120 parts of climbing groundsel, mother-in-law
120 parts of mother-in-law's fourth, 90 parts of Herba Lespedezae Cuneatae, 90 parts of lineate supplejack leaf, 80 parts of euphorbia fischeriana, 75 parts of mock-strawberry, 75 parts of Prunella vulgaris, 55 parts of Rhizoma Atractylodis Macrocephalae, the leaves of pulse plants
Fragrant 60 parts, 70 parts of Asiatic plantain, 70 parts of butterflybush flower, 70 parts of pipewort, 95 parts of purslane, 35 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Comparative example 1
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 50 parts of wormwood, 75 parts of climbing groundsel, mother-in-law
65 parts of mother-in-law's fourth, 45 parts of Herba Lespedezae Cuneatae, 55 parts of lineate supplejack leaf, 25 parts of euphorbia fischeriana, 30 parts of mock-strawberry, 20 parts of Prunella vulgaris, 10 parts of Rhizoma Atractylodis Macrocephalae, wrinkled giant hyssop
15 parts, 25 parts of Asiatic plantain, 15 parts of butterflybush flower, 25 parts of pipewort, 50 parts of purslane, 5 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Comparative example 2
A kind of bacterio static itching-relieving traditional Chinese medicine gel, is made of raw material from the following weight: 120 parts of wormwood, 145 parts of climbing groundsel,
155 parts of grandmother's fourth, 115 parts of Herba Lespedezae Cuneatae, 125 parts of lineate supplejack leaf, 105 parts of euphorbia fischeriana, 100 parts of mock-strawberry, 90 parts of Prunella vulgaris, Rhizoma Atractylodis Macrocephalae 70
Part, 85 parts of wrinkled giant hyssop, 95 parts of Asiatic plantain, 95 parts of butterflybush flower, 85 parts of pipewort, 110 parts of purslane, 50 parts of rhizoma anemarrhenae.
Preparation method is same as Example 1.
Clinical test
It chooses and suffers from dermopathic volunteer 900, it will be antibacterial made from the embodiment of the present application 1~7 and comparative example 1~2
Antipruritic traditional Chinese medicine gel, for treating, stops using other drugs using preceding 3d, during which simultaneously not with other drugs to volunteer
It uses.
One, case selection standard
1, diagnostic criteria
Symptom: part itch, surprise is itched, have dry skin cause itch, various skins discomfort；Prickly heat, mosquito bite and insect bite, erythema and too
Pruitus caused by sun is tanned severely.
2, it is included in standard
(1) meet above-mentioned diagnostic criteria person；
(2) age was in 22~70 years old person.
3, exclusion criteria
(1) above-mentioned tcm diagnosis standard person is not met；
(2) though meeting above-mentioned differential diagnosis in tcm standard, there is the one of following situation simultaneously:
1. the age is in under-18s or over-65s person；
2. pregnant and lying-in women or breast feeding women；
3. being associated with the severe primaries disease such as angiocarpy, liver, kidney and hemopoietic system, mental patient；
4. all do not meet the standard of being included in, not by regulation medication, it can not judge that curative effect or data be not congruent and affect the treatment and pacify
Full property judgement person.
Two, efficacy determination
1, with rear antipruritic effect
It is obviously improved (effective): using after 1~3d, not continuing to use, skin no longer itch；
There is improvement (effective): using after 8~10d, not continuing to use, skin no longer itch；
No improvement (invalid): using after 1~3d, skin itching symptom is without any improvement.
2, effective antipruritic time
Duration is long: after use in 1~3h effectively；
Duration is short: using effective in rear 1h.
3, whether there is allergic reaction
Severe allergic reaction: red dot, red and swollen phenomenon are played using rear skin；
Slight allergic reaction: red dot, red and swollen phenomenon are slightly played using rear skin.
Three, medication
Bacterio static itching-relieving traditional Chinese medicine gel made from the embodiment of the present application 1~7 and comparative example 1~2 is taken respectively, is directly applied to skin
Skin itch position.
Four, test result
Clinical test results are as shown in table 1 below.
1 clinical test results of table
| Group | Average onset time | It is effective | Effectively | Effective percentage/% |
| Embodiment 1 | 15min | 42 | 97 | 97 |
| Embodiment 2 | 22min | 49 | 98 | 98 |
| Embodiment 3 | 14min | 41 | 96 | 96 |
| Embodiment 4 | 17min | 40 | 95 | 95 |
| Embodiment 5 | 10min | 45 | 99 | 99 |
| Embodiment 6 | 16min | 45 | 96 | 96 |
| Embodiment 7 | 13min | 43 | 98 | 98 |
| Comparative example 1 | 29min | 19 | 76 | 76 |
| Comparative example 2 | 33min | 21 | 78 | 78 |
As 1 experimental data of table it is found that bacterio static itching-relieving traditional Chinese medicine gel product is after human body use made from the application method
There is certain antipruritic effect, redness caused by pruitus can be eliminated, volunteer is in use without allergic reaction, nothing
Obvious adverse reaction and toxic side effect, the antipruritic effect for the product that wherein prepared by embodiment 5 are best, antipruritic quick, treatments
It imitates, also longest of effective antipruritic time.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, nothing
By from the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended
Claim rather than above description limit, it is intended that by the institute in the meaning and scope for the equivalent loins for falling in claim
It changes and includes within protection scope of the present invention.
Claims (10)
1. a kind of bacterio static itching-relieving traditional Chinese medicine gel, which is characterized in that be made of raw material from the following weight: 60~100 parts of wormwood,
85~125 parts of climbing groundsel, 85~125 parts of grandmother's fourth, 65~95 parts of Herba Lespedezae Cuneatae, 65~95 parts of lineate supplejack leaf, euphorbia fischeriana 45~85
Part, 40~80 parts of mock-strawberry, 40~80 parts of Prunella vulgaris, 20~60 parts of Rhizoma Atractylodis Macrocephalae, 25~65 parts of wrinkled giant hyssop, 35~75 parts of Asiatic plantain, close illiteracy
Spend 35~75 parts, 35~75 parts of pipewort, 70~100 parts of purslane, 10~40 parts of rhizoma anemarrhenae.
2. a kind of bacterio static itching-relieving traditional Chinese medicine gel according to claim 1, which is characterized in that by the raw material of following parts by weight
It is made: 70~90 parts of wormwood, 95~115 parts of climbing groundsel, 95~115 parts of grandmother's fourth, 75~85 parts of Herba Lespedezae Cuneatae, lineate supplejack leaf 75~85
Part, 55~75 parts of euphorbia fischeriana, 50~70 parts of mock-strawberry, 50~70 parts of Prunella vulgaris, 30~50 parts of Rhizoma Atractylodis Macrocephalae, 35~55 parts of wrinkled giant hyssop, vehicle
First careless 45~65 parts, 45~65 parts of butterflybush flower, 45~65 parts of pipewort, 80~90 parts of purslane, 20~30 parts of rhizoma anemarrhenae.
3. a kind of bacterio static itching-relieving traditional Chinese medicine gel according to claim 1, which is characterized in that by the raw material of following parts by weight
It is made: 80 parts of wormwood, 105 parts of climbing groundsel, 105 parts of grandmother's fourth, 80 parts of Herba Lespedezae Cuneatae, 80 parts of lineate supplejack leaf, 65 parts of euphorbia fischeriana, mock-strawberry
60 parts, 60 parts of Prunella vulgaris, 40 parts of Rhizoma Atractylodis Macrocephalae, 45 parts of wrinkled giant hyssop, 55 parts of Asiatic plantain, 55 parts of butterflybush flower, 55 parts of pipewort, purslane 85
Part, 25 parts of rhizoma anemarrhenae.
4. a kind of preparation method of described in any item bacterio static itching-relieving traditional Chinese medicine gels, feature exist according to claim 1~3
In, comprising the following steps:
(1) wormwood, Po Poding, mock-strawberry, Prunella vulgaris, Rhizoma Atractylodis Macrocephalae, Asiatic plantain, butterflybush flower, pipewort and horse are weighed according to parts by weight
Bitterroot, after pulverizer was crushed to 10~30 meshes, drying, the clear water of 5~6 times of wormwood weight of addition, refluxing extraction 4~
6h, natural filtration obtain filtrate and filter residue；
(2) climbing groundsel, Herba Lespedezae Cuneatae, lineate supplejack leaf, euphorbia fischeriana, wrinkled giant hyssop and rhizoma anemarrhenae are weighed according to parts by weight, are added thousand after cleaning
In 2~3 times of light weight of boiled water, constant temperature impregnates, and ultrasonication, decompression filters, residue and step (1) must filter residue mix
It is even, it is sent into micronizer and is ground, 4~5 times of climbing groundsel weight of boiled water, 3~4h of refluxing extraction, decompression is then added
It filters, merges filtrate twice, the Aqueous extracts for being 1.0~1.3 to relative density are concentrated under reduced pressure；
(3) filtrate of step (1) is uniformly mixed, centrifugation slagging-off with step (2) Aqueous extracts, then carries out filling, be made described
Bacterio static itching-relieving traditional Chinese medicine gel.
5. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(1), the drying is by dry materials to water content lower than 50%；The temperature of the refluxing extraction is 65~70 DEG C.
6. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(2), the temperature that the constant temperature impregnates is 70~80 DEG C, and the time is 8~10h.
7. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(2), the frequency of the ultrasonication is 0.1~0.3MHz, and power is 300~350W, and the time is 20~25min.
8. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(2), the pressure of the grinding be 0.2~0.3MPa, temperature be 50~55 DEG C, by crushing material to particle diameter size be 10~
20μm。
9. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(2), the temperature of the refluxing extraction is 60~70 DEG C；The temperature of the reduced pressure be 70~75 DEG C, pressure be 200~
300Pa。
10. a kind of preparation method of bacterio static itching-relieving traditional Chinese medicine gel according to claim 4, it is characterised in that: in step
(3), the revolving speed of the centrifugation is 2800~3300rpm, and the time is 10~20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811454694.0A CN109260360A (en) | 2018-11-30 | 2018-11-30 | A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811454694.0A CN109260360A (en) | 2018-11-30 | 2018-11-30 | A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109260360A true CN109260360A (en) | 2019-01-25 |
Family
ID=65186624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811454694.0A Pending CN109260360A (en) | 2018-11-30 | 2018-11-30 | A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109260360A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
| CN105456420A (en) * | 2015-12-22 | 2016-04-06 | 李素萍 | Traditional Chinese medicine composition for treating skin allergy |
| CN106511511A (en) * | 2016-11-06 | 2017-03-22 | 宣伟 | Traditional Chinese medicine lotion for treating skin allergy |
| CN107308330A (en) * | 2016-04-27 | 2017-11-03 | 农立艳 | The infantile eczema Chinese medicinal lotion of low stimulation |
-
2018
- 2018-11-30 CN CN201811454694.0A patent/CN109260360A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
| CN105456420A (en) * | 2015-12-22 | 2016-04-06 | 李素萍 | Traditional Chinese medicine composition for treating skin allergy |
| CN107308330A (en) * | 2016-04-27 | 2017-11-03 | 农立艳 | The infantile eczema Chinese medicinal lotion of low stimulation |
| CN106511511A (en) * | 2016-11-06 | 2017-03-22 | 宣伟 | Traditional Chinese medicine lotion for treating skin allergy |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101732558A (en) | Traditional Chinese medicine granules used for treating chronic pharyngitis | |
| CN105285417A (en) | Formula feed for piglets and preparation method thereof | |
| CN105497261A (en) | Matrix of patch for external use and patch and sleeping-aid patch made from matrix | |
| CN103751511A (en) | Powder for improving sleeping | |
| CN108686023A (en) | A kind of antipruritic moisturizing essential oil for treating geroderma itch | |
| CN113398237A (en) | Traditional Chinese medicine composition with antibacterial, itching relieving and dandruff stopping functions and preparation method thereof | |
| CN100482257C (en) | Zuanshanfeng wind damp oil and its preparation method | |
| CN101120949B (en) | Traditional Chinese medicine for treating haemorrhoids | |
| CN109260360A (en) | A kind of bacterio static itching-relieving traditional Chinese medicine gel and preparation method thereof | |
| CN103028060B (en) | Traditional Chinese medicine composition for treating infant acute eczema and preparation method of traditional Chinese medicine composition | |
| CN101816756A (en) | Chinese medicinal composition for treating upset and irritability and preparation method thereof | |
| CN104799118A (en) | Dog food and preparation method thereof | |
| CN104043084B (en) | Cell cosmetic formulation | |
| CN103191399A (en) | Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period | |
| CN103446414A (en) | Xiangmahanchuantie (XMHCT) and preparation technology | |
| CN102319355B (en) | Chinese medicinal formula for treating hyperactivity and preparation method for pills thereof | |
| CN100998802A (en) | Chinese medicinal composition for treating chronic pharygitis | |
| CN104095910A (en) | Drug for treating respiratory diseases of minks | |
| CN103876207B (en) | Health soup for the treatment of tumor patient postoperative constipation and preparation method thereof | |
| CN108815332A (en) | A kind of composition of tonifying kidney and strengthening yang and the preparation method and application thereof | |
| CN102949656A (en) | Health care product capsule used for preventing and treating depression and preparation method thereof | |
| CN100406035C (en) | Chinese medicine preparation for treating protrasion of lumbar intervertebral disc | |
| CN105999003A (en) | Folium artemisiae argyi healthcare liquor for preventing and treating dysmenorrhea and preparation method thereof | |
| Hurd | Consumption in New England | |
| CN103932168B (en) | Health care soup for treatment of functional constipation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190125 |
|
| RJ01 | Rejection of invention patent application after publication |