CN109248201A - A kind of Chinese medicine composition and its application in preparation treatment antiarrhythmic medicament - Google Patents
A kind of Chinese medicine composition and its application in preparation treatment antiarrhythmic medicament Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine compositions for arrhythmia cordis, it is characterized in that, the Chinese medicine composition is made of following bulk pharmaceutical chemicals: frying 10~100 parts of wild jujube, 10~50 parts of tuber fleeceflower stem, 5~50 parts of the seed of Oriental arborvitae, 5~30 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 5~30 parts of the coptis, 5~30 parts of Flos Albiziae, 5~50 parts of Radix Salviae Miltiorrhizae, 5~25 parts of Herba Hyperici Monogyni, 0.2~2 part of pearl.It is confirmed by drug effect and clinical test, composition proposed by the present invention can effectively treat arrhythmia cordis.
Description
Technical field
The invention belongs to Chinese herbal medicine application fields, treat the heart more particularly to a kind of Chinese medicine composition and its in preparation
Restrain the application in arrhythmic agents.
Background technique
Arrhythmia cordis (arrhythmia) is clinical common disease, frequently-occurring disease, is primarily referred to as frequency, the section of cardiac impulse
Rule, origin position, conduction of velocity and exciting order exception.Arrhythmia cordis is equivalent in traditional Chinese medicine " palpitation ", " palpitaition " and " swoons
Faint " scope, belong to common clinical disease, various cardiovascular diseases can occur, and severe one easily causes heart failure, shock and A Yisi comprehensive
It levies and threat to life.
Clinic is still based on drug therapy at present, and the anti-arrhythmia Western medicine of nearly all listing, has to a certain degree
Ground reduces the self-disciplining of cardiac muscle, retardance cardiac conduction, inhibits myocardial contractive power, and has the adverse reaction for promoting arrhythmia cordis, very
To patient's late mortality rate is increased, with the rapid development of traditional Chinese medicine, Chinese medicine is with its curative effect affirmative, and adverse reaction is lower, gradually
As the important therapeutic modality and selection of clinical workers and patient, thus seek from tcm field the heart of high-efficiency low-toxicity
Restrain not normal new drug, it has also become one of the important directions and approach for the treatment of cardiac arrhythmia at present.
Summary of the invention
The purpose of the present invention is to provide a kind of new pharmaceutical composition, there is the composition blood-nourishing to pacify soul, relieving restlessness and restlessness
Function, prevention or treatment for arrhythmia cordis.
The present invention is realized by following technical solutions: a kind of Chinese medicine composition for arrhythmia cordis, feature
It is, which is made of following bulk pharmaceutical chemicals: 10~100 parts of wild jujube of stir-fry, 10~50 parts of tuber fleeceflower stem, the seed of Oriental arborvitae 5~50
Part, it is 5~30 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 5~30 parts of the coptis, 5~30 parts of Flos Albiziae, 5~50 parts of Radix Salviae Miltiorrhizae, 5~25 parts of Herba Hyperici Monogyni, precious
0.2~2 part of pearl.Described to be used for, can be all including treating or preventing is beneficial to improve the side of the corresponding symptom of patient
Formula.The composition can directly be pulverized by raw material, be also possible to by extract made from conventional means or other shapes
State etc..
Further, which is made of following bulk pharmaceutical chemicals: 40~80 parts of wild jujube of stir-fry, and 10~30 parts of tuber fleeceflower stem,
5~30 parts of the seed of Oriental arborvitae, 5~30 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 5~20 parts of the coptis, 5~20 parts of Flos Albiziae, 5~20 parts of Radix Salviae Miltiorrhizae, pass through leaf spun gold
5~20 parts of peach, 0.3~1 part of pearl.
Further, which is made of following bulk pharmaceutical chemicals: 45~55 parts of wild jujube of stir-fry, and 8~12 parts of tuber fleeceflower stem,
8~12 parts of the seed of Oriental arborvitae, 8~12 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 8~10 parts of the coptis, 5~8 parts of Flos Albiziae, 5~8 parts of Radix Salviae Miltiorrhizae, Herba Hyperici Monogyni 5
~8 parts, 0.5~0.8 part of pearl.
Preferably, which is made of following bulk pharmaceutical chemicals: 50 parts of Semen Ziziphi Spinosae (parched), 10 parts of tuber fleeceflower stem, and the seed of Oriental arborvitae 10
Part, 10 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 9 parts of the coptis, 6 parts of Flos Albiziae, 6 parts of Radix Salviae Miltiorrhizae, 6 parts of Herba Hyperici Monogyni, 0.6 part of pearl.
The invention also provides the preparation methods of such as aforementioned Chinese medicine composition, which is characterized in that the preparation method step is such as
Under:
Semen Ziziphi Spinosae (parched), tuber fleeceflower stem, the seed of Oriental arborvitae, steamed FRUCTUS SCHISANDRAE with vinegar part, the coptis, Flos Albiziae, Radix Salviae Miltiorrhizae and Herba Hyperici Monogyni are added 6
The water of~15 times of amounts extracts, extraction time 0.5-3h, extracts 2-4 times, filtered through gauze, combined extract, filtrate concentration
Ethanol solution is added in the concentrate for being 1.02~1.20 to relative density, and alcohol content is made to reach 40%-80%, places 24-48h,
Aspirate supernatant is concentrated into the concentrate that relative density is 1.05~1.30；Pearl is cleaned, and drying crushed 65~400 mesh
Sieve is to get pearl powder；The concentrate and pearl powder mix to obtain the final product.
The invention also provides a kind of such as the preparation method of aforementioned Chinese medicine composition, which is characterized in that preparation method step
It is rapid as follows:
Semen Ziziphi Spinosae (parched), tuber fleeceflower stem, the seed of Oriental arborvitae, steamed FRUCTUS SCHISANDRAE with vinegar, the coptis, Flos Albiziae, Radix Salviae Miltiorrhizae and Herba Hyperici Monogyni, addition 6~
The 40-95% ethyl alcohol of 15 times of amounts extracts, extraction time 0.5-3h, extracts 2-4 times, filtered through gauze is concentrated into relatively close
The concentrate that degree is 1.05~1.30；Pearl is cleaned, and drying crushed 65~400 meshes to get pearl powder, by above-mentioned concentration
Liquid and the pearl powder mix to obtain the final product.
The invention also provides a kind of such as the preparation method of aforementioned Chinese medicine composition, which is characterized in that preparation method step
It is rapid as follows:
Radix Salviae Miltiorrhizae and steamed FRUCTUS SCHISANDRAE with vinegar, 50~80% ethyl alcohol that 6~15 times of amounts are added extract, extraction time 0.5-3h,
It extracts 2-4 times, filtered through gauze, the dregs of a decoction are spare, combined extract, and filtrate is concentrated into the concentrate that relative density is 1.05~1.30
One；The above-mentioned dregs of a decoction and Semen Ziziphi Spinosae (parched), the seed of Oriental arborvitae, tuber fleeceflower stem, Flos Albiziae, Herba Hyperici Monogyni are added 6~15 times of water and are mentioned
Take, extraction time 0.5-3h, extract 2-4 time, filtered through gauze, combined extract, filtrate be concentrated into relative density for 1.02~
Ethanol solution is added in 1.20 concentrate, and alcohol content is made to reach 40%-80%, places 24-48h, and Aspirate supernatant is concentrated into
The concentrate two that relative density is 1.05~1.30；The coptis, be added 6~15 times amount water extract, extraction time be 0.5~
3h is extracted 2~4 times, filtered through gauze, combined extract, and filtrate is concentrated into the concentrate three that relative density is 1.05~1.30；It is precious
Pearl is cleaned, drying, crushed 65~400 meshes, after the concentrate one, concentrate two, concentrate three and pearl powder mixing i.e.
?.
More specifically, steps are as follows for the preparation method of aforementioned Chinese medicine composition: 10 times of amounts are added in Radix Salviae Miltiorrhizae and steamed FRUCTUS SCHISANDRAE with vinegar
60% ethyl alcohol extracts, extraction time 2h, extracts 3 times, filtered through gauze, the dregs of a decoction are spare, and combined extract, filtrate is concentrated into
The concentrate one that relative density is 1.25；The above-mentioned dregs of a decoction and Semen Ziziphi Spinosae (parched), the seed of Oriental arborvitae, tuber fleeceflower stem, Flos Albiziae, Herba Hyperici Monogyni,
12 times of water is added to extract, extraction time 2h is extracted 3 times, filtered through gauze, combined extract, and filtrate is concentrated into relatively
Ethanol solution is added in the concentrate that density is 1.10, and alcohol content is made to reach 65%, places for 24 hours, Aspirate supernatant is concentrated into phase
The concentrate two for being 1.25 to density；The coptis, the water that 10 times of amounts are added extract, and extraction time 1.5h is extracted 3 times, yarn
Cloth filtering, combined extract, filtrate are concentrated into the concentrate three that relative density is 1.25；Pearl is cleaned, and drying crushed 200
Mesh is to get pearl powder, after the concentrate one, concentrate two, concentrate three and pearl powder mixing to obtain the final product.
The invention also provides application of any aforementioned Chinese medicine composition in the drug that preparation is used for arrhythmia cordis.
The invention also provides a kind of drugs for arrhythmia cordis, which is characterized in that the drug is by any aforementioned Chinese medicine
Composition and pharmaceutically acceptable auxiliary material are made.
Specifically, which can be tablet, capsule, granule, pill, injection, soft extract, suspending agent, dispersion
The dosage forms such as agent, syrup, suppository, gelling agent, aerosol, patch, oral solution.
The auxiliary material, can be different according to different preparations, such as in tablet, capsule, granule solid pharmaceutical preparation
In common diluent, disintegrating agent, adhesive, lubricant, surfactant, filler etc.；The common surface in oral solution
Activating agent, diluent, preservative, stabilizer, corrigent, thickener, glidant etc..
Its common auxiliary material such as starch, lactose, dextrin, Icing Sugar, microcrystalline cellulose, mannitol, xylitol, polyethylene glycol, sulphur
Sour calcium, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, polyvinyl pyrrolidone, sodium carboxymethylcellulose, hydroxypropyl methylcellulose
Element, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose, PVP K30, white bole, pregelatinized starch,
Magnesium stearate, talcum powder, superfine silica gel powder, stevioside glycosides, glycine betaine, aspartame, glycyrrhizin, saccharin sodium, citric acid, carbonic acid
Hydrogen sodium, sodium carbonate, carragheen, agar, gelatin, sodium alginate, xanthan gum, stearic acid, glycerin monostearate, sorbic acid, mountain
Potassium sorbate, ethyl hydroxy benzoate, benzyl alcohol, dimethyl sulfoxide, propylene glycol, lauryl sodium sulfate, Tweens, spans etc..
Further, which is added dextrin, sodium carboxymethylcellulose and Sucralose by the Chinese medicine composition, mixes
It is even, it is made after dry granulation.
Present invention further proposes any aforementioned Chinese medicine composition in preparation for the application in cardiac extra systole drug.It should
Cardiac extra systole for example can be ventricular premature beat.
Pharmaceutical composition provided by the invention is the blood-nourishing tonifying liver using Semen Ziziphi Spinosae (parched) as monarch drug in a prescription, antitoxic heart-soothing and sedative.The seed of Oriental arborvitae is mended
Nourishing heart gas, nourishing yin and nourishing blood；Steamed FRUCTUS SCHISANDRAE with vinegar, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves；Tuber fleeceflower stem, mental-tranquilization；Radix Salviae Miltiorrhizae, replenishing and activating blood；It is altogether
Ministerial drug, to increase the power of Semen Ziziphi Spinosae (parched).The coptis, clearing heart fire；Pearl, tranquilizing mind are adjutant.Flos Albiziae and pass through leaf spun gold
Peach, liver soothing and depression relief, to make medicine.
Full side is made a general survey of, first benefiting qi and nourishing yin blood-nourishing, making negative hemapodium, then blood vessels fill, and qi and blood is strong multiple and yin is spontaneous, throb with fear and determine and arteries and veins
Multiple, sweat stops and yin is deposited.Second clearing heat and relieving fidgetness calming heart mind, the mind is quiet, and all diseases of palpitaition dysphoria what have.Full side's collection QI invigorating is supported
Blood, heat clearing and tranquillizing is in one, and one pacifies the body of nourishing heart arteries and veins both disease, and the mind of the two restriction internal heat rash action, supplementing qi and nourishing yin is without making blood
The row stasis of blood is stagnant, the disadvantage of clearing heat and cooling blood and lossless impairment of qi yin, and body and the spirit holds palpitaition holism of body and spirit with controlling, the qi and blood people having the same aspiration and interest, and illness is same
It controls.All medicine phases 5, treating both manifestation and root cause of disease, it is clear in have benefit, bowl spares has row, mends without stagnant, grows and oiliness, fills qi and blood foot, yin-fluid, dysphoria with smothery sensation
It goes, then palpitaition disappears.
Pharmacodynamic test shows that composition of the invention has preferably curative effect to Aconitine Induced rat ventricular premature beat,
BaCl2It causes in rat ventricular model and the experiment of myocardial ischemia induced rat arrhythmia cordis, the present composition can make the rhythm of the heart
The death rate of the decreased duration of not normal time of occurrence delay, ventricular tachycardia and the incidence and animal that reduce ventricular fibrillation, passes through medicine
Effect or clinical test show that composition of the invention has the function for the treatment of arrhythmia cordis.
Specific embodiment
The person that is such as not specified actual conditions is tested below, is carried out according to conventional conditions or manufacturer's recommended conditions, it is used
Bulk pharmaceutical chemicals or auxiliary material and reagents or instruments used without specified manufacturer are that can be produced by the routine of commercially available acquisition
Product.Unless otherwise stated, otherwise all percentage, ratio, ratio or number be by weight.
Unless otherwise defined, it anticipates known to all professional and scientific terms as used herein and one skilled in the art
Justice is identical.In addition, any method similar to or equal to what is recorded and material can all be applied and the present invention.
Following preparation methods in relation to the present composition or preparation only enumerate the obtained through refining method of the present invention, but do not answer
This is interpreted as preparation method of the invention and is only limited to above-mentioned cited method.
Embodiment 1
Semen Ziziphi Spinosae (parched) 5000g, seed of Oriental arborvitae 1000g, tuber fleeceflower stem 1000g, Flos Albiziae 600g, Herba Hyperici Monogyni 600g, vinegar five
Taste 1000g, Radix Salviae Miltiorrhizae 600g and coptis 900g, 60% ethyl alcohol that 10 times of amounts are added extract, and extraction time 2h extracts 3
It is secondary, filtered through gauze, combined extract, filtrate be concentrated into relative density be 1.25 concentrate, dry, pulverize.60g pearl, washes
Only, it dries, crushed 200 meshes to get pearl powder.The intermediates such as above-mentioned concentrate or pearl powder, mix, and be added dextrin,
Sodium carboxymethylcellulose and Sucralose, mix, dry granulation to get.
Embodiment 2
Semen Ziziphi Spinosae (parched) 5000g, seed of Oriental arborvitae 1000g, tuber fleeceflower stem 1000g, Flos Albiziae 600g, Herba Hyperici Monogyni 600g, vinegar five
Taste 1000g, Radix Salviae Miltiorrhizae 600g and coptis 900g, are added 12 times of water and extract, and extraction time 2h is extracted 3 times, gauze mistake
Filter, combined extract, filtrate are concentrated into the concentrate that relative density is 1.10, and ethanol solution is added, alcohol content is made to reach 65%,
It places for 24 hours, Aspirate supernatant, is concentrated into the concentrate that relative density is 1.25, dry, pulverize.60g pearl is cleaned, drying,
200 meshes be crushed to get pearl powder.Dextrin, sodium carboxymethylcellulose and Sucralose is added in above-mentioned intermediate, mixes, and does
Method granulation to get.
Embodiment 3
Steamed FRUCTUS SCHISANDRAE with vinegar 1000g and Radix Salviae Miltiorrhizae 600g, 60% ethyl alcohol that 10 times of amounts are added extract, and extraction time 2h is mentioned
It taking 3 times, filtered through gauze, the dregs of a decoction are spare, combined extract, and filtrate is concentrated into the concentrate that relative density is 1.25, after dry, powder
It is broken.The above-mentioned dregs of a decoction and Semen Ziziphi Spinosae (parched) 5000g, seed of Oriental arborvitae 1000g, tuber fleeceflower stem 1000g, Flos Albiziae 600g, Herba Hyperici Monogyni 600g,
12 times of water is added to extract, extraction time 2h is extracted 3 times, filtered through gauze, combined extract, and filtrate is concentrated into relatively
Ethanol solution is added in the concentrate that density is 1.10, and alcohol content is made to reach 65%, places for 24 hours, Aspirate supernatant is concentrated into phase
The concentrate for being 1.25 to density, dry, pulverize.Coptis 900g, the water that 10 times of amounts are added extract, and extraction time is
1.5h is extracted 3 times, filtered through gauze, combined extract, and filtrate is concentrated into the concentrate that relative density is 1.25, dry, pulverize.
60g pearl is cleaned, and drying crushed 200 meshes to get pearl powder.Above-mentioned intermediate mixes, and dextrin, carboxymethyl is added
Sodium cellulosate and Sucralose, mix, dry granulation to get.
The pharmacodynamic study of 1 present composition of experimental example
1, experimental material
Given the test agent title: the Chinese medicine composition prepared according to the method for embodiment 1,2,3；Positive control drug: hydrochloric acid is general
Naphthalene Luo Er piece, specification: 10mg, national drug standard H41020667, Anyang Yu Wei pharmaceutical Co. Ltd；Aconitine, Chinese drug biology
Product examines and determine institute, lot number 16121111；SOD, MDA kit, Beijing China English biotechnology research institute；SPF grades of SD rats, weight
200g is provided, production licence number: SCXK (capital) 2016-0011 by Beijing dimension tonneau China Experimental Animal Center.
2, experimental method
It early tests 2.1 Aconitine Induced rat rooms
Take SD rat 50 to be only randomly divided into 5 groups, model group, Propranolol group, 1,2,3 group of Chinese medicine composition give respectively by
According to above-described embodiment 1,2,3 prepare sample, every group 10.Propranolol group gives the Propranolol stomach-filling of 2mg/kg, Chinese medicine
1,2,3 group of composition in accordance with the above-mentioned embodiment 1,2,3 preparation samples give 9.7g crude drug/kg stomach-filling, the daily stomach-filling of model group
With treatment group with the physiological saline of isometric(al), continuous 7 days, after last medication 1h, 4% hydration was injected intraperitoneally in daily stomach-filling 1 time
After chloralization is complete, lies on the back and is fixed on four limbs on mouse plate and is subcutaneously plugged needle-like electrode, and be connected to biological functional system,
Display lead electrocardiogram has injected observation lead electrocardio immediately in sublingual vein injection aconitine 20 μ g/kg, 5s after electrocardio is stablized
The appearance of variation record rat room morning and termination time calculate rat room early latent time and duration.
Influence of 1 Chinese medicine composition of table to rat room morning
P < 0.01 * P < 0.05 compared with model control group, * *
The result shows that compared with model group Propranolol group, the present composition three kinds of Different Preparation group rats
Room incubation period morning is longer, and room duration morning is shorter, the statistically significant P < 0.05 of difference, P < 0.01, wherein according to implementation
Sample effect prepared by example 3 is best, shows that the present composition has preferably curative effect for ventricular premature beat.
2.2BaCl2Cause rat ventricular experiment
Model group, Propranolol group, 1,2,3 group of Chinese medicine composition give respectively in accordance with the above-mentioned embodiment 1,2,3 preparation
Sample, every group 10.Propranolol group gives the Propranolol stomach-filling of 2mg/kg, and 1,2,3 group of Chinese medicine composition according to above-mentioned reality
The sample for applying the preparation of example 1,2,3 gives 9.7g crude drug/kg stomach-filling, the daily stomach-filling of model group and treatment group with the physiology salt of isometric(al)
Continuous 7 days, after last medication 1h, fiber crops are injected intraperitoneally with 10% chloraldurate (300mg/kg) in rat by water, daily stomach-filling 1 time
Liquor-saturated layback position is fixed, and side vena jugularis externa is removed, and the electrocardiac channel (II lead) on biological functional system is connected, from oscillography
After observing ECG to stabilization on device, 0.3%BaCl is injected by 4mg/kg through vena jugularis externa2, the heart is observed continuously from oscillograph immediately
Electrograph variation, records arrhythmia cordis time of occurrence and duration.Rat aorta takes centrifugation point after blood after detection electrocardiogram
From serum, it is stand-by to be stored in -80 DEG C of refrigerators.Detect MDA, SOD.
Influence of 2 Chinese medicine composition of table to rat ventricular
#P < 0.05 compared with Normal group, ##P < 0.01；P < 0.01 * P < 0.05 compared with model control group, * *
The result shows that in the influence to arrhythmia cordis time of occurrence and duration, Propranolol group, present invention combination
Three kinds of Different Preparation groups of object have significant differences (P < 0.01) compared with model group, wherein according to embodiment 1,2
The sample of preparation has significant difference (P < 0.05) compared with model group；Model group is compared with Normal group, Content of MDA
Obvious to rise, SOD activity is decreased obviously (p < 0.01).Three groups of samples of the invention can be substantially reduced MDA content, enhance SOD
Active function (p < 0.05), and sample prepared by embodiment 3 shows preferable curative effect, shows that the present composition can
For treating BaCl2The Experimental Arrhythmia of induction.
The experiment of 2.3 myocardial ischemia induced rat arrhythmia cordis
Male SD rat 50 is taken only to be randomly divided into 5 groups, model group, Propranolol group, 1,2,3 group of Chinese medicine composition, every group
10.Propranolol group gives the Propranolol stomach-filling of 2mg/kg, 1,2,3 group of Chinese medicine composition in accordance with the above-mentioned embodiment 1,2,3
The sample of preparation gives 9.7g crude drug/kg stomach-filling, the daily stomach-filling of model group and treatment group with the physiological saline of isometric(al), fills daily
Stomach 1 time, continuous 7 days, 3% yellow Jackets 30mgkg after last medication 1h-1Intraperitoneal anesthesia, dorsal position are fixed on warm stage
On, trachea cannula is successfully followed by animal breathing apparatus.60 min of respiratory rate-1, IE ratio 3: 1, ventilatory capacity
1ml·g-1.From left side, the second intercostal opens chest, cuts off pericardium, and exposure heart is handed in pulmonary conus left border and left auricle of heart lower edge
Gone out needle from inserting needle from left auricle of heart lower edge 1mm with No. 0/3 suture at boundary in pulmonary conus left border, heart is resetted, stablized
Following coronary artery occlusion descending anterior branch after 10min.II lead electrocardiogram is monitored with eight conductive physiographs in the process, counts the heart
The time of occurrence of groups of animals ventricular arrhythmia, duration, the incidence of ventricular fibrillation and death occur in myocardial ischemia 20min
Rate.
Influence of 3 Chinese medicine composition of table to myocardial ischemia induced rat arrhythmia cordis
P < 0.01 * P < 0.05 compared with model control group, * *
The result shows that in the influence to arrhythmia cordis time of occurrence and duration, Propranolol group, present invention combination
3 groups of object have significant differences (P < 0.01) compared with model group, and 1,2 group of the present composition has significantly compared with model group
Sex differernce (P < 0.05), the present composition can be such that the time of occurrence of arrhythmia cordis postpones, the decreased duration of ventricular tachycardia and drop
The incidence of low ventricular fibrillation and the death rate of animal show that the present composition can be used for treating ischemic arrhythmia.
The clinical application of 2 present composition of experimental example
To illustrate the effect that the traditional chinese medicine composition of the invention treats premature beat, with the particle prepared according to 3 method of embodiment, carry out
Lower example clinical test.
1, diagnostic criteria
1.1 Western medicine diagnostic criterias (referring to " practical clinical practice ")
1) symptom: even originator no obvious symptom, or occur palpitaition or heartbeat pause sense, frequency originator may occur in which it is out of strength,
The symptoms such as dizziness, very then angina pectoris attacks.
2) sign: the visible rhythm of the heart of cardiac auscultation is irregular, there is longer compensatory pause after premature beat, and the first heart sound of premature beat increases
By force, second heart sound weakens or disappears, and pulse palpation can find that interval pulse lacks such as.
3) atrial premature beats Electrocardiogram Feature: the room P' wave occurred in advance, form is different from sinus property P wave, PR interphase >
0.12 second；There is the QRS complex of normal morphology after room P' wave；Compensatory pause is incomplete.
4) ventricular premature beat Electrocardiogram Feature: the QRS complex of the roomy deformity occurred in advance, time limit > 0.12 second, T wave was general
Contrary with main wave, ST sections shift with T wave；Without P wave before it；Compensatory pause is complete.
1.2 tcm diagnosis standards (referring to " Chinese Internal Medicine ")
1) consciously palpitation with fear in the heart not oneself, it is in paroxysmal or duration breaking-out that heartbeat is abnormal, fast or slow, or neglects to jump and neglect only,
Palpitation and restlessness, cannot be autonomous；It can be seen that the pulse conditions such as number, rush, knot, generation, puckery, slow, heavy, slow.
2) it does not relax with uncomfortable in chest, emotional, shortness of breath, vexed irritability is out of strength, the diseases such as dizzy, insomnia.Middle-older patient, can
With ambition pain, very then syndrome characterized by dyspnea or is shown in syncope at cold extremities due to sweating.
2, outpatient 58 are collected referring to above-mentioned standard, is randomly divided into control group and administration group, every group 29.Treatment group
Male 18, female 11；Administration group, male 15, female 14.Two groups in terms of gender, age, the course of disease and ill-distribution through statistics
There was no significant difference (P > 0.05) for processing.
3, medication
Drug of the present invention is given by treatment group, and 35.87g crude drug/time, 3 times a day.It is each that control group takes orally propafenone tablet
(100~150mg), 3 times a day.24 hours dynamic ecg recordings examinations are carried out after medication 4 weeks.
4, experimental result
The comparison of premature beat total effects after 4.1 two groups of treatments
As can be seen from Table 3, after two groups of patient's treatments, the symptom of premature beat is obviously improved, and treatment group's total effective rate is
79.31%, control group total effective rate 72.41% shows that the present composition has the function for the treatment of premature beat.
The comparison of premature beat total effects after 3 two groups of treatments of table
Tcm syndrome total effects compare after 4.2 two groups of patient's treatments
After treating, the total effective rate for the treatment of group and control group is respectively 82.76% and 72.41%, as shown in table 4, table
The bright present composition has the function for the treatment of premature beat.
The comparison of premature beat total effects after 4 two groups of treatments of table
5, experiment conclusion
Above-mentioned clinical test shows that the traditional chinese medicine composition of the invention has definitely curative effect for premature beat.
The above embodiment of the present invention is not pair just for the sake of that can clearly demonstrate examples made by the present invention
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (10)
1. one kind is used for arrhythmia cordis Chinese medicine composition, which is characterized in that the Chinese medicine composition is made of following bulk pharmaceutical chemicals: frying acid
10~100 parts of jujube, 10~50 parts of tuber fleeceflower stem, 5~50 parts of the seed of Oriental arborvitae, 5~30 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 5~30 parts of the coptis, Flos Albiziae 5
~30 parts, 5~50 parts of Radix Salviae Miltiorrhizae, 5~25 parts of Herba Hyperici Monogyni, 0.2~2 part of pearl.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is made of following bulk pharmaceutical chemicals: frying
40~80 parts of wild jujube, 10~30 parts of tuber fleeceflower stem, 5~30 parts of the seed of Oriental arborvitae, 5~30 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 5~20 parts of the coptis, Flos Albiziae 5
~20 parts, 5~20 parts of Radix Salviae Miltiorrhizae, 5~20 parts of Herba Hyperici Monogyni, 0.3~1 part of pearl.
3. Chinese medicine composition according to claim 2, which is characterized in that the Chinese medicine composition is made of following bulk pharmaceutical chemicals: frying
50 parts of semen ziziphi spinosae, 10 parts of tuber fleeceflower stem, 10 parts of the seed of Oriental arborvitae, 10 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 9 parts of the coptis, 6 parts of Flos Albiziae, 6 parts of Radix Salviae Miltiorrhizae, pass through leaf
6 parts of Hypericum Chinense, 0.6 part of pearl.
4. the preparation method of Chinese medicine composition as described in claim 1-3 is any, which is characterized in that the preparation method step is such as
Under:
Semen Ziziphi Spinosae (parched), tuber fleeceflower stem, the seed of Oriental arborvitae, steamed FRUCTUS SCHISANDRAE with vinegar, the coptis, Flos Albiziae, Radix Salviae Miltiorrhizae and Herba Hyperici Monogyni are added 6~15 times
The water of amount extracts, extraction time 0.5-3h, extracts 2-4 times, filters combined extract, and it is molten that ethyl alcohol is added after filtrate concentration
Liquid makes alcohol content reach 40%-80%, places 24-48h, and Aspirate supernatant obtains concentrate after concentration；
Pearl is cleaned, dries, crushed 65~400 meshes to get pearl powder；Above-mentioned concentrate and the pearl powder are mixed
To obtain the final product.
5. the preparation method of Chinese medicine composition as described in claim 1-3 is any, which is characterized in that the preparation method step is such as
Under:
Semen Ziziphi Spinosae (parched), tuber fleeceflower stem, the seed of Oriental arborvitae, steamed FRUCTUS SCHISANDRAE with vinegar, the coptis, Flos Albiziae, Radix Salviae Miltiorrhizae and Herba Hyperici Monogyni are added 6~15 times
The 40-95% ethyl alcohol of amount extracts, extraction time 0.5-3h, extracts 2-4 times, and filtering obtains concentrate after concentration；
Pearl is cleaned, is dried, crushed 65~400 meshes to get pearl powder, above-mentioned concentrate and the pearl powder are mixed
To obtain the final product.
6. the preparation method of Chinese medicine composition as described in claim 1-3 is any, which is characterized in that the preparation method step is such as
Under:
Radix Salviae Miltiorrhizae and steamed FRUCTUS SCHISANDRAE with vinegar, 50~80% ethyl alcohol that 6~15 times of amounts are added extract, and extraction time 0.5-3h is extracted
2-4 times, filtering, the dregs of a decoction are spare, combined extract, and filtrate is concentrated to give concentrate one；
The above-mentioned dregs of a decoction and Semen Ziziphi Spinosae (parched), the seed of Oriental arborvitae, tuber fleeceflower stem, Flos Albiziae, Herba Hyperici Monogyni are added 6~15 times of water and are mentioned
It takes, extraction time 0.5-3h, extracts 2-4 times, filtered through gauze, combined extract, ethanol solution is added after filtrate concentration, makes to contain
Alcohol amount reaches 40%-80%, places 24-48h, and Aspirate supernatant obtains concentrate two after concentration；
The coptis, the water that 6~15 times of amounts are added extract, and extraction time is 0.5~3h, is extracted 2~4 times, filtered through gauze, merge
Extracting solution obtains concentrate three after filtrate concentration；
Pearl is cleaned into drying, crushed 65~400 meshes to get pearl powder, aforementioned concentrate one, concentrate two, concentrate
Three and pearl powder mixing after to obtain the final product.
7. application of the Chinese medicine composition in the drug that preparation is used for arrhythmia cordis as described in claim 1-3 is any.
8. a kind of drug for arrhythmia cordis, which is characterized in that the drug is by any Chinese medicine composition of claim 1-3
It is made with pharmaceutically acceptable auxiliary material.
9. drug according to claim 8, which is characterized in that dextrin, carboxylic first is added by the Chinese medicine composition in the drug
Base sodium cellulosate and Sucralose mix, and are made after dry granulation.
10. Chinese medicine composition is in preparation for the application in cardiac extra systole drug as described in claim 1-3 is any.
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| 乔赟等: "《新编药性歌括400味：配彩图》", 31 August 2017, 河南科学技术出版社 * |
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